Log in

Relevant bibliographies by topics / Fibroblast; Collagen; Tissue metabolism

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers

Academic literature on the topic 'Fibroblast; Collagen; Tissue metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Fibroblast; Collagen; Tissue metabolism.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Fibroblast; Collagen; Tissue metabolism"

1

Havemose-Poulsen, Anne, and Palle Holmstrup. "Factors Affecting IL-1-Mediated Collagen Metabolism By Fibroblasts and the Pathogenesis of Periodontal Disease: A Review of the Literature." Critical Reviews in Oral Biology & Medicine 8, no. 2 (1997): 217–36. http://dx.doi.org/10.1177/10454411970080020801.

Full text

Abstract:

Fibroblasts have been studied extensively for their contribution to connective tissue destruction in diseases where the metabolism of extracellular matrix components plays an essential part in their pathogenesis. A considerable dissolution, especially of collagen fibrils, is a well-known characteristic of the periodontal ligament and the gingival connective tissue in microbial-induced periodontal disease. Fibroblasts, responsible for the assembly of the extracellular matrix, are capable of responding directly to oral microbial challenges or indirectly, following activation of the host immune r

APA, Harvard, Vancouver, ISO, and other styles

2

Togo, Shinsaku, Xiangde Liu, Xingqi Wang та ін. "PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-β1-stimulated fibroblasts". American Journal of Physiology-Lung Cellular and Molecular Physiology 296, № 6 (2009): L959—L969. http://dx.doi.org/10.1152/ajplung.00508.2007.

Full text

Abstract:

Fibrotic diseases are characterized by the accumulation of extracellular matrix together with distortion and disruption of tissue architecture. Phosphodiesterase (PDE)4 inhibitors, by preventing the breakdown of cAMP, can inhibit fibroblast functions and may be able to mitigate tissue remodeling. Transforming growth factor (TGF)-β1, a mediator of fibrosis, can potentially modulate cAMP by altering PGE2 metabolism. The present study assessed whether PDE4 inhibitors functionally antagonize the profibrotic activity of fibroblasts stimulated by TGF-β1. The PDE4 inhibitors roflumilast and rolipram

APA, Harvard, Vancouver, ISO, and other styles

3

Karna, Ewa, Lukasz Szoka, Thi Yen Ly Huynh, and Jerzy A. Palka. "Proline-dependent regulation of collagen metabolism." Cellular and Molecular Life Sciences 77, no. 10 (2019): 1911–18. http://dx.doi.org/10.1007/s00018-019-03363-3.

Full text

Abstract:

AbstractThis review is focused on recent data on the role of proline (Pro) in collagen biosynthesis and cellular metabolism. It seems obvious that one of the main substrates for collagen biosynthesis Pro is required to form collagen molecule. The question raised in this review is whether the Pro for collagen biosynthesis is synthesized “de novo”, comes directly from degraded proteins or it is converted from other amino acids. Recent data provided evidence that extracellular Pro (added to culture medium) had significant, but relatively little impact on collagen biosynthesis in fibroblasts (the

APA, Harvard, Vancouver, ISO, and other styles

4

Kössi, Jyrki, Marko Vähä-Kreula, Juha Peltonen, Juha Risteli, and Matti Laato. "Effect of Sucrose on Collagen Metabolism in Keloid, Hypertrophic Scar, and Granulation Tissue Fibroblast Cultures." World Journal of Surgery 25, no. 2 (2001): 142–46. http://dx.doi.org/10.1007/s002680020038.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Zervolea, Irene, Harris Pratsinis, Stylianos Tsagarakis, et al. "The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing’s syndrome." European Journal of Endocrinology 152, no. 6 (2005): 895–902. http://dx.doi.org/10.1530/eje.1.01913.

Full text

Abstract:

Objective: Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs may generate permanent adverse functional changes, we have investigated whether chronic in vivo exposure to GC excess results in persisting defects in skin fibroblasts. Design and methods: We have studied in vitro primary skin fibroblast cultures obtained from patients suffering

APA, Harvard, Vancouver, ISO, and other styles

6

Zhang, Y., K. Dreißigacker, D. Distler та ін. "AB0172 PGC-1Α REGULATES AUTOPHAGY TO PROMOTE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS". Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1386.2–1386. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3603.

Full text

Abstract:

Background:Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is the best studied member of the family of coactivators. PGC-1α was initially identified through its interaction with PPARγ in brown adipose tissue. Recent evidence further indicates that PGC-1α may also modulate the transcription of autophagy-related genes, which has recently been shown to be required for fibroblast-to-myofibroblast differentiation under fibrotic conditions. However, the role of PGC-1α in the pathogenesis of SSc has not been investigated.Objectives:The aim of the present study was to evaluate

APA, Harvard, Vancouver, ISO, and other styles

7

Patrick Abergel, R., Damon Pizzurro, Cheryl A. Meeker, et al. "Biochemical Composition of the Connective Tissue in Keloids and Analysis of Collagen Metabolism in Keloid Fibroblast Cultures." Journal of Investigative Dermatology 84, no. 5 (1985): 384–90. http://dx.doi.org/10.1111/1523-1747.ep12265471.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Arlien-Søborg, Mai C., Camilla Grøndahl, Amanda Bæk, et al. "Fibroblast Activation Protein is a GH Target: A Prospective Study of Patients with Acromegaly Before and After Treatment." Journal of Clinical Endocrinology & Metabolism 105, no. 1 (2019): 106–15. http://dx.doi.org/10.1210/clinem/dgz033.

Full text

Abstract:

Abstract Background Fibroblast growth factor 21 (FGF21) is a circulating hormone with pleiotropic metabolic effects, which is inactivated by fibroblast activation protein (FAP). Data regarding interaction between FGF21, FAP, and growth hormone (GH) are limited, but it is noteworthy that collagens are also FAP substrates, since GH potently stimulates collagen turnover. Aim To measure circulating FGF21 components, including FAP, in patients with acromegaly before and after disease control. Methods Eighteen patients with active acromegaly were studied at the time of diagnosis and ≥ 6 months after

APA, Harvard, Vancouver, ISO, and other styles

9

Langholz, O., D. Röckel, C. Mauch, et al. "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins." Journal of Cell Biology 131, no. 6 (1995): 1903–15. http://dx.doi.org/10.1083/jcb.131.6.1903.

Full text

Abstract:

The reorganization of extracellular matrix (ECM) is an important function in many biological and pathophysiological processes. Culture of fibroblasts in a three-dimensional collagenous environment represents a suitable system to study the underlying mechanisms resulting from cell-ECM interaction, which leads to reprogramming of fibroblast biosynthetic capacity. The aim of this study was to identify receptors that transduce ECM signals into cellular events, resulting in reprogramming of connective tissue metabolism. Our data demonstrate that in human skin fibroblasts alpha 1 beta 1 and alpha 2

APA, Harvard, Vancouver, ISO, and other styles

10

Silver, Frederick H., Nikita Kelkar, and Tanmay Deshmukh. "Molecular Basis for Mechanical Properties of ECMs: Proposed Role of Fibrillar Collagen and Proteoglycans in Tissue Biomechanics." Biomolecules 11, no. 7 (2021): 1018. http://dx.doi.org/10.3390/biom11071018.

Full text

Abstract:

Collagen and proteoglycans work in unison in the ECM to bear loads, store elastic energy and then dissipate excess energy to avoid tissue fatigue and premature mechanical failure. While collagen fibers store elastic energy by stretching the flexible regions in the triple helix, they do so by lowering their free energy through a reduction in the entropy and a decrease in charge–charge repulsion. Entropic increases occur when the load is released that drive the reversibility of the process and transmission of excess energy. Energy is dissipated by sliding of collagen fibrils by each other with t

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Fibroblast; Collagen; Tissue metabolism"

1

Keerthisingam, Carmel Beulin. "Role of prostaglandin Eâ‚‚ in the pathogenesis of pulmonary fibrosis." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325631.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Burns-Cox, Nicholas. "Changes in collagen metabolism in benign and malignant human prostatic tissue." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326694.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Phillips, Christian Hambro. "Collagen metabolism in vaginal and uterosacral tissue of women with pelvic organ prolapse." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398733.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Cornwell, Kevin G. "Collagen and fibrin biopolymer microthreads For bioengineered ligament regeneration." Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-050407-104302/.

Full text

Abstract:

Dissertation (Ph.D.) -- Worcester Polytechnic Institute.<br>Keywords: Ligament; ACL; Collagen; Fibrin; Microthread; Fiber; Thread; FGF-2; Fibroblast; Tissue regeneration; Tissue engineering. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

5

Cornwell, Kevin. "Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/324.

Full text

Abstract:

Rupture of the anterior cruciate ligament (ACL) of the knee leads to chronic joint instability and reduced range of motion while the long term results are marred by a high prevalence of degenerative joint disease especially osteoarthritis. Bundles of collagen threads have been widely investigated for the repair of torn ACL, but are limited by insufficient tissue ingrowth to repopulate and completely regenerate these grafts. We have developed a novel in vitro method of characterizing fiber-based thread matrices by probing their ability to promote tissue ingrowth from a wound margin as a measure

APA, Harvard, Vancouver, ISO, and other styles

6

Ahlfors, Jan-Eric Wilhelm. "A Comparative Analysis of the Biomechanics and Biochemistry of Cell-Derived and Cell-Remodeled Matrices: Implications for Wound Healing and Regenerative Medicine." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0503104-172949/.

Full text

Abstract:

Thesis (M.S.) -- Worcester Polytechnic Institute.<br>Keywords: tension; failure strain; fibroblasts; regenerative medicine; serum-free; proteoglycans; glycosaminoglycans; collagen; wound-healing model; cell-remodeled matrix; cell-derived matrix; biomechanical characterization; fibrin gel; growth factors; tissue growth; total protein content; tissue formation. Includes bibliographical references (p.44-53).

APA, Harvard, Vancouver, ISO, and other styles

7

Naue, Janine. "Histologische Charakterisierung eines murinen Knorpeldestruktionsmodells in der BALB/c Maus." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-184744.

Full text

Abstract:

Die rheumatoide Arthritis ist eine chronisch-entzündliche Bindegewebserkrankung mit symmetrischem Befall der Gelenke. Die genaue Ätiologie ist bisher unbekannt. Aktivierte synoviale Fibroblasten sollen durch gesteigerte Adhäsion und Produktion von proinflammatorischen Zytokinen und Matrix-lysierenden Proteasen maßgeblich an der Gelenkdestruktion beteiligt sein. Ziel dieser Arbeit war es, ein neues in-vivo-Knorpeldestruktions-Modell zu etablieren, in welchem unter immunkompetenten Bedingungen, die Invasion und Destruktion von Gelenkknorpel durch die Fibroblasten-Zelllinie LS48 über einen länger

APA, Harvard, Vancouver, ISO, and other styles

8

Zhang, Weiping. "Effects of tobacco on human gingival fibroblasts." Thesis, 2011. http://hdl.handle.net/1805/2712.

Full text

Abstract:

Indiana University-Purdue University Indianapolis (IUPUI)<br>The negative heath consequences of smoking are widely recognized, but there are still about 20% of the people in United States using tobacco products. Cigarette smoke condensate (CSC), the particulate matter of cigarette smoke, is comprised of thousands of chemicals (e.g., nicotine). Secondary only to bacterial plaque, cigarette smoking is a major risk factor for periodontal disease. Human gingival fibroblasts (HGFs) are the main cellular component of periodontal connective tissues. During the development of periodontal disease,

APA, Harvard, Vancouver, ISO, and other styles

9

Schlick, Susanne. "Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E57D-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Sur, Sumon. "Control of cardiogenesis and homeostasis by cardiac fibroblasts." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-87B6-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Fibroblast; Collagen; Tissue metabolism"

1

United States. National Aeronautics and Space Administration., ed. An evaluation of collagen metabolism in non-human primates associated with the Bion Space Program-markers of urinary collagen turnover and muscle tissue collagen types: NASA progress report, NAG-2-769. National Aeronautics and Space Administration, 1996.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

United States. National Aeronautics and Space Administration., ed. An evaluation of collagen metabolism in non-human primates associated with the Bion Space Program-markers of urinary collagen turnover and muscle tissue collagen types: NASA progress report, NAG-2-769. National Aeronautics and Space Administration, 1996.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

3

Control of Tissue Damage (Research Monographs in Cell & Tissue Physiology). Elsevier Science Ltd, 2000.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

4

M, Glauert Audrey, Strangeways Research Laboratory (Cambridge, England), and International Symposium on "The Control of Tissue Damage" (1987 : Babraham, England), eds. The Control of tissue damage: Strangeways Research Laboratory 75th anniversary symposium, 6-8 April 1987. Elsevier, 1988.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

5

Voinescu, Alexandra, Nadia Wasi Iqbal, and Kevin J. Martin. Pathophysiology of chronic kidney disease-mineral and bone disorder. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0117.

Full text

Abstract:

Chronic kidney disease is associated with the inability to control normal mineral homeostasis, resulting in abnormalities in serum levels of calcium, phosphorus, parathyroid hormone, fibroblast growth factor 23 (FGF23) and vitamin D metabolism. These disturbances lead to the development of secondary hyperparathyroidism, skeletal abnormalities, vascular calcifications, and other systemic manifestations. Traditionally, mineral and bone abnormalities seen in chronic kidney disease were included in the term ‘renal osteodystrophy’. More recently, the term chronic kidney disease-mineral and bone dis

APA, Harvard, Vancouver, ISO, and other styles

6

P, Mecham Robert, ed. Regulation of matrix accumulation. Academic Press, 1986.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

7

Bardin, Thomas, and Tilman Drüeke. Renal osteodystrophy. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149.

Full text

Abstract:

Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by h

APA, Harvard, Vancouver, ISO, and other styles

8

Covic, Adrian, Mugurel Apetrii, Luminita Voroneanu, and David J. Goldsmith. Vascular calcification. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0120_update_001.

Full text

Abstract:

Vascular calcification (VC) is a common feature of patients with advanced CKD and it could be, at least in part, the cause of increased cardiovascular mortality in these patients. From a morphologic point of view, there are at least two types of pathologic calcium phosphate deposition in the arterial wall—namely, intima calcification (mostly associated with atherosclerotic plaques) and media calcification (associated with stiffening of the vasculature, resulting in significantly adverse cardiovascular outcomes). Although VC was viewed initially as a passive phenomenon, it appears to be a cell-

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Fibroblast; Collagen; Tissue metabolism"

1

Brenner, R. E., A. Nerlich, U. Vetter, M. Bodo, W. M. Teller, and P. K. Müller. "Collagen Metabolism in Childhood: A Study on Compact Bone and Fibroblast Cultures." In Neuere Ergebnisse in der Osteologie. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74770-0_22.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Schachtschabel, D. O. "In Vitro Studies of Fibroblast Aging: Growth Factors, Collagen and Glycosaminoglycan Synthesis — a Review." In Cell and Tissue Culture Models in Dermatological Research. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77817-9_28.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Etherington, D. J., R. A. Maciewicz, M. A. J. Taylor, et al. "The role of collagen-degrading cysteine proteinases in connective tissue metabolism." In Cysteine Proteinases and their Inhibitors, edited by Vito Turk. De Gruyter, 1986. http://dx.doi.org/10.1515/9783110846836-030.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Ehrlich, H. P. "The Role of the Connective Tissue Matrix in Wound Healing: Fibroblast and Collagen Interactions." In Wound Healing and Skin Physiology. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-77882-7_8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Moortgat, Peter, Jill Meirte, Ulrike Van Daele, Mieke Anthonissen, Tine Vanhullebusch, and Koen Maertens. "Vacuum Massage in the Treatment of Scars." In Textbook on Scar Management. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44766-3_54.

Full text

Abstract:

AbstractVacuum massage is a noninvasive mechanical massage technique performed with a mechanical device that lifts the skin by means of suction to create and mobilize a skin fold. It was invented by a French engineer suffering from burn scars after a car accident and has since then been frequently used for the treatment of burn scars.The two most reported physical effects of vacuum massage were improvement of the tissue hardness and the elasticity of the skin. Besides physical effects, a variety of physiological effects are reported in the literature, for example, an increased number of fibroblasts and collagen fibers accompanied by an alteration of fibroblast phenotype and collagen orientation. Little information was found on the decrease of pain and itch due to vacuum massage.Although vacuum massage initially had been developed for the treatment of burn scars, a literature review found little evidence for the efficacy of this treatment. Variations in duration, amplitude, or frequency of the treatment have a substantial influence on collagen restructuring and reorientation, thus implying possible beneficial influences on the healing potential by mechanotransduction pathways. Vacuum massage may release the mechanical tension associated with scar retraction and thus induce apoptosis of myofibroblasts. Suggestions for future research include upscaling the study design, investigating the molecular pathways and dose dependency, comparing effects in different stages of repair, including evolutive parameters and the use of more objective assessment tools.

APA, Harvard, Vancouver, ISO, and other styles

6

Matikainen, Niina, and Sanni Söderlund. "Fibroblast Growth Factor 21 as a Regulator of Energy Metabolism in the Liver and Adipose Tissue." In Nutrition in the Prevention and Treatment of Abdominal Obesity. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-816093-0.00013-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Matikainen, Niina. "Fibroblast Growth Factor 21 is a Regulator of Energy Metabolism in the Liver and Adipose Tissue." In Nutrition in the Prevention and Treatment of Abdominal Obesity. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-407869-7.00039-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Bardin, Thomas, and Tilman Drüeke. "Renal osteodystrophy." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149_update_001.

Full text

Abstract:

Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by histology: (1) osteitis fibrosa as the bony expression of secondary hyperparathyroidism (sHP), which is a high bone turnover disease developing early in CKD; (2) adynamic bone disease (ABD), the most frequent type of ROD in dialysis patients, which is at present most often observed in the absence of aluminium intoxication and develops mainly as a result of excessive PTH suppression; and (3) mixed ROD, a combination of osteitis fibrosa and osteomalacia whose prevalence has decreased in the last decade. Laboratory features include increased serum levels of PTH and bone turnover markers such as total and bone alkaline phosphatases, osteocalcin, and several products of type I collagen metabolism products. Serum phosphorus is increased only in CKD stages 4-5. Serum calcium levels are variable. They may be low initially, but hypercalcaemia develops in case of severe sHP. Serum 25-OH-vitamin D (25OHD) levels are generally below 30 ng/mL, indicating vitamin D insufficiency or deficiency. The international KDIGO guideline recommends serum PTH levels to be maintained in the range of approximately 2-9 times the upper normal normal limit of the assay and to intervene only in case of significant changes in PTH levels. It is generally recommended that calcium intake should be up to 2 g per day including intake with food and administration of calcium supplements or calcium-containing phosphate binders. Reduction of serum phosphorus towards the normal range in patients with endstage kidney failure is a major objective. Once sHP has developed, active vitamin D derivatives such as alfacalcidol or calcitriol are indicated in order to halt its progression.

APA, Harvard, Vancouver, ISO, and other styles

9

Drüeke, Tilman, and Thomas Bardin. "Renal osteodystrophy." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0149_update_002.

Full text

Abstract:

Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. Its main clinical expression is an increased propensity for fractures. It has been divided into several pathological entities based on histomorphometry criteria of bone turnover, mineralization and volume. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and α‎-klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can be schematically divided into three main types by histology: (1) osteitis fibrosa reflecting secondary hyperparathyroidism (sHP) is a high bone turnover disease which can develop early in CKD; (2) adynamic bone disease (ABD), at present the predominant type of ROD in dialysis patients, which is mainly the result of PTH resistance or excessive PTH suppression; and (3) mixed ROD, a combination of osteitis fibrosa and osteomalacia whose prevalence has decreased in the last decade. Laboratory features include increased serum levels of PTH and bone turnover markers such as total and bone-specific alkaline phosphatases, osteocalcin, and several products of type I collagen metabolism products. Serum phosphorus increases only in advanced CKD (stages G4-G5). Serum calcium levels are variable. They may be low initially, but hypercalcaemia develops in case of severe sHP. Serum 25-OH-vitamin D levels are generally below 30 ng/mL, indicating vitamin D insufficiency or deficiency. The international KDIGO guideline recommends serum PTH levels to be maintained in the range of approximately 2-9 times the upper normal limit of the assay and to intervene only in case of significant changes in PTH levels. It is generally recommended that calcium intake should be up to 2 g per day including intake with food and administration of calcium supplements or calcium-containing phosphate binders. Reduction of serum phosphorus towards the normal range in patients with endstage renal disease is a major objective. Once sHP has developed, active vitamin D derivatives such as alfacalcidol or calcitriol, and in addition calcimimetics in dialysis patients, can be used to halt its progression.

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Fibroblast; Collagen; Tissue metabolism"

1

Thomopoulos, Stavros, Vedran Knezevic, Kevin D. Costa, and Jeffrey W. Holmes. "Development of Anisotropy in Fibroblast Populated Collagen Gels." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32781.

Full text

Abstract:

The development of anisotropic mechanical properties is critical for the successful tissue engineering of many soft tissues. Load bearing tissues naturally develop varying degrees of anisotropy, presumably in response to their specific loading environment. For example, the heart wall develops a collagen structure that varies in a predictable manner through its depth [1]. Tendon, on the other hand, develops a matrix that does not vary much in orientation and is highly aligned in the direction of muscle loading [2]. These varied levels of anisotropy may be due to inherent differences between the

APA, Harvard, Vancouver, ISO, and other styles

2

Bell, Brett J., and Sherry L. Voytik-Harbin. "Multiaxial Study of Fibroblast Biomechanics in a 3D Collagen Matrix." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206722.

Full text

Abstract:

It is becoming increasingly evident, that of the signaling modalities relevant to the cell-extracellular matrix (ECM) microenvironment, the mechanical component is a very important mediator of cell behavior (reviewed in [1, 2]). Indeed, proliferation, ECM protein expression (collagen), matrix metalloproteinase (MMP) levels, migration, and stem cell differentiation, have all been shown to be affected by mechanical environmental cues [3, 4]. Although the importance of physical signaling mechanisms has been well established, the bulk of this work has yet to be translated to a more physiologic 3D

APA, Harvard, Vancouver, ISO, and other styles

3

Cheng, Yu-Chen, and Pen-Hsiu Grace Chao. "A Model for Ligament Fibroblast Migration Into Provisional Matrix." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53858.

Full text

Abstract:

Many strategies have been proposed to enhance the healing capability of the anterior cruciate ligament (ACL). A novel treatment option, called enhanced primary repair, places a provisional matrix at the tear site to promote cell infiltration of the wound and aims to reestablish the structure-function relationship of the ACL [1]. This approach of guided tissue regeneration offers great potential benefits of retaining the complex native tissue matrix structure, innervation, and vascularization as compared with grafts. A major aspect of this procedure is enhancing ligament fibroblast infiltration

APA, Harvard, Vancouver, ISO, and other styles

4

Thomopoulos, Stavros, and Jeffrey W. Holmes. "A Structural Basis for Anisotropy in Cardiac Fibroblast Populated Collagen Gels." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61209.

Full text

Abstract:

The development of anisotropic mechanical properties is critical for the successful function of many soft tissues. Load bearing tissues naturally develop varying degrees of anisotropy, presumably in response to their specific loading environment. For example, the scar tissue that forms after a myocardial infarction is structurally and mechanically anisotropic. To better understand the scar mechanics, we first need to develop structure-function relationships for collagen fiber networks. In order to improve the healing after myocardial infarction, a better understanding of the mechanical anisotr

APA, Harvard, Vancouver, ISO, and other styles

5

Raghupathy, Ramesh, Spencer P. Lake, Edward A. Sander, Colleen Witzenburg, and Victor H. Barocas. "Anisotropic Inverse Mechanics Identifies Regional Changes in Mechanical Anisotropy During Remodelling of Fibroblast-Populated Collagen Cruciforms." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53177.

Full text

Abstract:

Most elastographic methods applied to soft tissues assume either isotropy or homogeneity in the sample. While this assumption is valid in specific cases, general methods that can identify regional changes in mechanical anisotropy have many advantages. Chiefly, such methods could quantify regional anisotropic material behavior on intact tissue samples especially when the tissue is heterogeneous and too small for standard tests. In this study we use an inverse mechanics method which handles both anisotropy and heterogeneity to track changes in mechanical anisotropy associated with remodeling in

APA, Harvard, Vancouver, ISO, and other styles

6

Schiele, Nathan R., Douglas B. Chrisey, and David T. Corr. "Proliferation and Fiber Formation of Human Dermal Fibroblasts on Patterned Differentially Adherent Substrates." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192910.

Full text

Abstract:

Fibroblast cells are crucial in the human body for maintenance of the extracellular matrix, including synthesizing macromolecules like collagen, and they play a critical role in wound healing of soft tissues such as skin [1]. Directing fibroblast growth is an important step in tissue engineering where the focus has gone from a top-down approach of homogeneously introducing cells into a pre-formed scaffold to a bottom-up approach in which the tissue construct is built on a cell-by-cell basis with ability to manipulate specific cell environments through location, proximity, and geometry. The abi

APA, Harvard, Vancouver, ISO, and other styles

7

Liu, Chun-Yuan, Wei-Ren Chang, Wei-Bor Tsai, and Pen-Hsiu Grace Chao. "Effect of Solvent on Electrospun PLLA Fiber Mechanical Characteristics and Ligament Fibroblast Responses." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19339.

Full text

Abstract:

Due to the poor healing ability of anterior cruciate ligaments (ACL), surgical interventions with graft materials are often needed to reconstruct the knee joint. Electrospinning is widely utilized to manufacture highly aligned fibrous materials. When cultured on such substrates, ligament fibroblasts are known to exhibit elongation and enhanced collagen production [1, 2]. Poly-L-lactic-acid (PLLA) is a popular biocompatible material with high mechanical strength, and is most often used in electrospinning with chloroform as solvent. Hexafluoropropanol (HFP), another solvent, generates more unifo

APA, Harvard, Vancouver, ISO, and other styles

8

Jageneau, A., W. Loots, A. Nevelsteen, and F. De Clerck. "PLATELET-MEDIATED REDUCTION OF PERIPHERAL TISSUE PERFUSION IN THE CAT : SEROTONIN AND PROSTANOIDS ARE CAUSAL VASOACTIVE MODULATORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644599.

Full text

Abstract:

In cats, a femoral artery was ligated in order to mobilize a collateral circulation in the hind leg, leaving the contralateral artery intact. Graded infusions of collagen (50 to 400 μg/kg) in the aorta above the bifurcation reduced the blood flow, mainly in the collateral circulation (> 80 %). Plasma 5-HI and TXB2 increased in local arterial blood. Ketanserin or ritanserin (S2-receptor blockade, 0.63 mg/kg I.V.) and dazoxiben or R 68070 (TXA2 synthetase inhibition, 5 and 1.25 mg/kg I.V.) reduced (> 50 %, p < 0.05) the collagen-induced loss of tissue perfusion. Indomethacin (10 mg/kg I

APA, Harvard, Vancouver, ISO, and other styles

9

Merryman, W. David, and Joshua D. Hutcheson. "Controlling the Mechanical Myofibroblast via SRC: A Potential Drug Discovery Platform." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19187.

Full text

Abstract:

Connective tissue makes up a large portion of our bodies, with collagen constituting ∼30% of the protein of connective tissue. Any tissue that undergoes fibrosis, either due to a genetic mutation or with age or use, typically falls into the ubiquitous category of ‘connective tissue fibrosis’. There are multiple potential contributors to connective tissue fibrosis; however, two dominate the literature — mechanical stress/strain and cytokines. Both stimuli lead to activation of fibroblast cells to a myofibroblast phenotype, the cellular hallmark of fibrotic disease. The myofibroblast phenotype i

APA, Harvard, Vancouver, ISO, and other styles

10

Gould, Russell, Karen Chin, Puifai Santisakultam та ін. "Anisotropic Strain Fields Enhance Matrix Remodeling Through Elevated TGF-β Signaling". У ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53805.

Full text

Abstract:

In this work, we demonstrate the unique effect of controlled anisotropic strain on fibroblast behavior in 3D engineered tissue environments. Anisotropy of biaxial strain resulted in increased cellular orientation and collagen fiber alignment. Transforming growth factor beta-1 (TGFβ1) gene expression and pSmad2 nuclear translocation increased with biaxial directionality. Myofibroblastic alpha-smooth muscle actin (α-SMA) decreased with applied strain similar to mechanically unloaded hydrogels. Collectively, these results demonstrate a novel mechanobiological mechanism by which fibroblasts develo

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!