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Journal articles on the topic 'Fibroblast formation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Heng, Madalene. "Phosphorylase Kinase Inhibition Therapy in Burns and Scalds." BioDiscovery 20 (February 24, 2017): e11207. https://doi.org/10.3897/biodiscovery.20.e11207.

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Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblas

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Lebel, Mégane, Dominic O. Cliche, Martine Charbonneau, et al. "Invadosome Formation by Lung Fibroblasts in Idiopathic Pulmonary Fibrosis." International Journal of Molecular Sciences 24, no. 1 (2022): 499. http://dx.doi.org/10.3390/ijms24010499.

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Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal fibroblast accumulation in the lung leading to extracellular matrix deposition and remodeling that compromise lung function. However, the mechanisms of interstitial invasion and remodeling by lung fibroblasts remain poorly understood. The invadosomes, initially described in cancer cells, consist of actin-based adhesive structures that coordinate with numerous other proteins to form a membrane protrusion capable of degrading the extracellular matrix to promote their invasive phenotype. In this regard, we hypothesized that invadoso

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Qian, Huan, Yihan Shan, Ruicheng Gong, et al. "Fibroblasts in Scar Formation: Biology and Clinical Translation." Oxidative Medicine and Cellular Longevity 2022 (May 12, 2022): 1–11. http://dx.doi.org/10.1155/2022/4586569.

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Scarring, which develops due to fibroblast activation and excessive extracellular matrix deposition, can cause physical, psychological, and cosmetic problems. Fibroblasts are the main type of connective tissue cells and play important roles in wound healing. However, the underlying mechanisms of fibroblast in reaching scarless wound healing require more exploration. Herein, we systematically reviewed how fibroblasts behave in response to skin injuries, as well as their functions in regeneration and scar formation. Several biocompatible materials, including hydrogels and nanoparticles, were als

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Cai, Zhou, Hua Guo, Jing Qian та ін. "Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway". PeerJ 10 (27 липня 2022): e13775. http://dx.doi.org/10.7717/peerj.13775.

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Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”. Aberrant activation of TGF-β1 is frequently encountered and promotes fibroblast proliferation, activation, and differentiation in pulmonary fibrosis. Hence, the inhibition of TGF-β1-induced lung fibroblast activation holds promise as a therapeutic strategy for IPF. The present study aimed to investigate the potential effect and underlying mechanisms of bone morphogenetic prote

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Koo, Kyo-in, Andreas Lenshof, Le Thi Huong, and Thomas Laurell. "Acoustic Cell Patterning in Hydrogel for Three-Dimensional Cell Network Formation." Micromachines 12, no. 1 (2020): 3. http://dx.doi.org/10.3390/mi12010003.

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In the field of engineered organ and drug development, three-dimensional network-structured tissue has been a long-sought goal. This paper presents a direct hydrogel extrusion process exposed to an ultrasound standing wave that aligns fibroblast cells to form a network structure. The frequency-shifted (2 MHz to 4 MHz) ultrasound actuation of a 400-micrometer square-shaped glass capillary that was continuously perfused by fibroblast cells suspended in sodium alginate generated a hydrogel string, with the fibroblasts aligned in single or quadruple streams. In the transition from the one-cell str

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Kohlhauser, Michael, Marcel Mayrhofer, Lars-Peter Kamolz, and Christian Smolle. "An Update on Molecular Mechanisms of Scarring—A Narrative Review." International Journal of Molecular Sciences 25, no. 21 (2024): 11579. http://dx.doi.org/10.3390/ijms252111579.

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Fibroblasts, the principal cellular mediators of connective tissue remodeling, play a crucial role in the formation of physiological and pathological scars. Understanding the intricate interplay between fibroblasts and other cellular and molecular components is essential for elucidating the underlying mechanisms driving scar formation. Hypertrophic scars, keloids and atrophic scars arise from dysregulated wound healing processes characterized by persistent inflammation, aberrant collagen deposition, and impaired extracellular matrix remodeling. Fibroblasts play a central role in the pathogenes

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Newman, Andrew C., Martin N. Nakatsu, Wayne Chou, Paul D. Gershon, and Christopher C. W. Hughes. "The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation." Molecular Biology of the Cell 22, no. 20 (2011): 3791–800. http://dx.doi.org/10.1091/mbc.e11-05-0393.

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A role for fibroblasts in physiological and pathological angiogenesis is now well recognized; however, the precise mechanisms underlying their action have not been determined. Using an in vitro angiogenesis model in combination with a candidate gene approach, column chromatography, and mass spectrometry, we identify two classes of fibroblast-derived factors—one that supports vessel sprouting but not lumen formation, and one that promotes lumen formation. In the absence of fibroblasts a combination of angiopoietin-1, angiogenin, hepatocyte growth factor, transforming growth factor-α, and tumor

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Yoon, Dajeong, Dogeon Yoon, Heejoong Sim, Inseok Hwang, Ji-Seon Lee, and Wook Chun. "Accelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model." Stem Cells International 2018 (December 30, 2018): 1–12. http://dx.doi.org/10.1155/2018/4789568.

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Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. In this study, we tested whether human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) could be differentiated into fibroblasts considering that the

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Srinivasan, Suseela, Jennifer Strange, Feyisola Awonusonu, and Margaret C. Bruce. "Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset." American Journal of Physiology-Lung Cellular and Molecular Physiology 282, no. 3 (2002): L457—L467. http://dx.doi.org/10.1152/ajplung.00050.2001.

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After alveolar formation, >20% of interstitial lung fibroblasts undergo apoptosis, a process that is of critical importance for normal lung maturation. The immature lung contains two morphologically distinct fibroblast populations, lipid-filled interstitial fibroblasts (LIF) and non-LIF (NLIF), which differ with respect to contractile protein content, proliferative capacity, and expression of mRNAs for fibronectin and types I and III collagen, but not tropoelastin. After alveolarization, apoptosis occurs in only one fibroblast population, the LIF. Using flow cytometry to analyze fibroblasts

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Volin, Michael, Brian Zanotti, Karolina Klosowska, et al. "Rheumatoid arthritis synovial tissue fibroblast Mucin 3 expression and function (54.27)." Journal of Immunology 188, no. 1_Supplement (2012): 54.27. http://dx.doi.org/10.4049/jimmunol.188.supp.54.27.

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Abstract Mucin 3 (MUC3) is elevated in rheumatoid arthritis (RA) synovial tissues (STs). We hypothesized that MUC3 is expressed by RA synovial fibroblasts, that it is cytokine inducible and chemotactic for RA synovial fibroblasts. To test this, RA synovial fibroblast MUC3 expression was determined by immunohistochemistry, flow cytometry and Western blot analysis. Levels of MUC3 from arthritic synovial fluids (SFs) were measured by a novel MUC3 ELISA. RA synovial fibroblast chemotaxis to RA SFs was assessed using a modified Boyden chamber assay. RA ST cells stained for both MUC3 and vimentin in

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Kunz-Schughart, Leoni A., Josef A. Schroeder, Marit Wondrak, et al. "Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro." American Journal of Physiology-Cell Physiology 290, no. 5 (2006): C1385—C1398. http://dx.doi.org/10.1152/ajpcell.00248.2005.

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The development of vessel-like structures in vitro to mimic as well as to realize the possibility of tissue-engineered small vascular networks presents a major challenge to cell biologists and biotechnologists. We aimed to establish a three-dimensional (3-D) culture system with an endothelial network that does not require artificial substrates or ECM compounds. By using human skin fibroblasts and endothelial cells (ECs) from the human umbilical vein (HUVECs) in diverse spheroid coculture strategies, we verified that fibroblast support and modulate EC migration, viability, and network formation

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Ng-Blichfeldt, John-Poul, Tristan de Jong, Rosa K. Kortekaas та ін. "TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation". American Journal of Physiology-Lung Cellular and Molecular Physiology 317, № 1 (2019): L14—L28. http://dx.doi.org/10.1152/ajplung.00400.2018.

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Transforming growth factor-β (TGF-β)-induced fibroblast-to-myofibroblast differentiation contributes to remodeling in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, but whether this impacts the ability of fibroblasts to support lung epithelial repair remains little explored. We pretreated human lung fibroblasts [primary (phFB) or MRC5 cells] with recombinant human TGF-β to induce myofibroblast differentiation, then cocultured them with adult mouse lung epithelial cell adhesion molecule-positive cells (EpCAM+) to investigate their capacity to support epithelial organoi

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Gray, A. J., J. T. Reeves, N. K. Harrison, P. Winlove, and G. J. Laurent. "Growth factors for human fibroblasts in the solute remaining after clot formation." Journal of Cell Science 96, no. 2 (1990): 271–74. http://dx.doi.org/10.1242/jcs.96.2.271.

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Fibroblasts adhere to, and readily grow into, fibrin clots that form as a result of the cleavage of fibrinogen by thrombin. Subsequent fibroblast replication is believed to be stimulated by mitogens released by entrapped platelets, such as platelet-derived growth factor. We suggest that the supernatant remaining after the fibrinogen-thrombin reaction could stimulate fibroblast replication, even in the absence of other blood components. To examine this hypothesis we expressed liquid from a fibrin clot and measured its mitogenic activity on human lung fibroblasts, in serum-free conditions, using

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Gallagher, Ann Marie, Tristram D. Bahnson, Hisahiro Yu, Noel N. Kim, and Morton P. Printz. "Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 3 (1998): H801—H809. http://dx.doi.org/10.1152/ajpheart.1998.274.3.h801.

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Cardiac fibroblasts, an abundant cell of the left ventricle (LV), proliferate and synthesize collagen in the heart after acute injury and during pressure overload hypertrophy. From many studies, angiotensin II (ANG II) receptors have been implicated in promoting collagen formation by the rat cardiac fibroblast. The present study examined species variability in ANG II receptor expression. Cultured rat fibroblasts expressed 43,000 ± 15,000 ANG II (AT1-specific) receptors per cell (dissociation constant = 0.92 ± 0.34 nM), whereas rabbit and neonate human cardiac fibroblast cultures expressed few

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Gamble, Darian J., Samantha Lopez, Melody Yazdi, Toni Castro-Torres, and Thomas P. Lozito. "Probe Sequencing Analysis of Regenerating Lizard Tails Indicates Crosstalk Among Osteoclasts, Epidermal Cells, and Fibroblasts." Journal of Developmental Biology 13, no. 2 (2025): 15. https://doi.org/10.3390/jdb13020015.

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Lizards are distinguished as the only amniotes, and closest relatives of mammals, capable of multilineage epimorphic regeneration. Tail blastemas of green anole lizards (Anolis carolinensis) consist of col3a1+ fibroblastic connective tissue cells enclosed in krt5+ wound epidermis (WE), both of which are required for regeneration. Blastema and WE formation are known to be closely associated with phagocytic cell populations, including macrophages and osteoclasts. However, it remains unclear what specific phagocytic cell types are required to stimulate regeneration. Here, we explicitly assess the

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Liu, Zhikun, Lining Xian, Jianmin Li, Shudan Zheng, and Hongju Xie. "Single-cell RNA sequencing analysis reveals the role of TXNDC5 in keloid formation." Cytojournal 21 (October 31, 2024): 40. http://dx.doi.org/10.25259/cytojournal_58_2024.

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Objective: Thioredoxin domain-containing protein 5 (TXNDC5) is associated with fibrosis in a variety of organs, but its mechanism of action in keloid is unclear. In this study, we aimed to investigate the mechanism of TXNDC5 in keloid. Material and Methods: Single-cell RNA sequencing data of keloid and normal scar samples obtained from public databases were normalized and clustered using the Seurat package. Pathway enrich analysis was conducted using biological process enrichment analysis and Gene Set Enrichment Analysis (GSEA). In addition, TXNDC5 expression and its effects on migration and i

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Magliano, Marina Pasca di. "Abstract IA19: Oncogenic KRAS and the regulation of the pancreatic cancer microenvironment." Molecular Cancer Research 21, no. 5_Supplement (2023): IA19. http://dx.doi.org/10.1158/1557-3125.ras23-ia19.

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Abstract Pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer, is characterized by almost universal presence of oncogenic KRAS. A key characteristic of pancreatic cancer is the abundant accumulation of tumor microenvironment, rich in infiltrating immune cells and an extensive fibroblast population. Pancreatic cancer is preceded by precursor lesions known as Pancreatic Intraepithelial Neoplasia (PanIN); PanIN formation is accompanied by the formation of a pre-TME. Analysis of donor pancreas from healthy individual revealed that PanIN is common in human samples, and accomp

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Seo, Cheong Hoon, Hui Song Cui, and June-Bum Kim. "Calpastatin-Mediated Inhibition of Calpain Ameliorates Skin Scar Formation after Burn Injury." International Journal of Molecular Sciences 22, no. 11 (2021): 5771. http://dx.doi.org/10.3390/ijms22115771.

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Hypertrophic scars, the most common complication of burn injuries, are characterized by excessive deposition of fibroblast-derived extracellular matrix proteins. Calpain, a calcium-dependent protease, is involved in the fibroblast proliferation and extracellular matrix production observed in certain fibrotic diseases. However, its role in the formation of post-burn hypertrophic skin scars remains largely unknown. Here, calpain expression and activity were assessed in skin fibroblasts obtained directly from patients with third-degree burns, who consequently developed post-burn hypertrophic scar

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Opsahl, Emily Lasse, Carlos E. Espinoza, Katelyn L. Donahue, et al. "Abstract A063: The role of JAK/STAT3 signaling in lung premetastatic niche formation and progression." Cancer Research 84, no. 17_Supplement_2 (2024): A063. http://dx.doi.org/10.1158/1538-7445.pancreatic24-a063.

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Abstract Pancreatic ductal adenocarcinoma (PDA) is a highly deadly disease with a five-year survival rate of only 13%. Oncogenic KRAS (Kras) is a near-universal driver of PDA, and its activity is required for the formation of PDA precursor lesions, pancreatic intraepithelial neoplasia (PanIN). PanIN formation is accompanied by fibrosis and immune cell infiltration, creating a precursor tumor microenvironment that is maintained and evolves through disease progression. Our previous work has demonstrated that Kras in epithelial cells drives fibroblast activation during very early stages of pancre

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Welch, M. P., G. F. Odland, and R. A. Clark. "Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction." Journal of Cell Biology 110, no. 1 (1990): 133–45. http://dx.doi.org/10.1083/jcb.110.1.133.

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Wound contraction can substantially reduce the amount of new tissue needed to reestablish organ integrity after tissue loss. Fibroblasts, rich in F-actin bundles, generate the force of wound contraction. Fibronectin-containing microfibrils link fibroblasts to each other and to collagen bundles and thereby provide transduction cables across the wound for contraction. The temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction have not been determined. To establish these relationships, we used a cutane

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Rosenbaum, T., Y. L. Boissy, K. Kombrinck, et al. "Neurofibromin-deficient fibroblasts fail to form perineurium in vitro." Development 121, no. 11 (1995): 3583–92. http://dx.doi.org/10.1242/dev.121.11.3583.

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To identify cell type(s) that might contribute to nerve sheath tumors (neurofibromas) in patients with neurofibromatosis type 1, we generated cell cultures containing neurons. Schwann cells and fibroblasts from transgenic mouse embryos in which the type 1 neurofibromatosis gene was disrupted by homologous recombination (Brannan et al. (1994) Genes Development, 8,1019-1029). Normal fascicle formation by perineurial cells failed to occur in the absence of neurofibromin. Fascicles were reduced in number and showed abnormal morphology when normal neurons and Schwann cells were cultured up to 37 da

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Merkel, G. J. "Effects of culture conditions on the in vitro infection of fibroblasts by Candida albicans." Canadian Journal of Microbiology 38, no. 2 (1992): 135–42. http://dx.doi.org/10.1139/m92-022.

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The effects of yeast culture age, carbon source, growth temperature, and germ-tube inducers on adherence to primary fibroblast cultures was studied in conjunction with the determination of adherence-mediated mammalian cell damage by measuring chromium-51 release from fibroblast monolayers. The results indicated that yeast culture age affected adherence only when the yeasts were grown at 37 °C, not after growth at 28 °C. At 37 °C, quantitatively fewer exponential-phase, glucose- or galactose-grown yeasts adhered to fibroblasts than did yeasts that were in lag or stationary phases. The reduced a

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Aguiar, Alexis, Melissa Galinato, Maite’ Bradley Silva, Bryant Toth, Michael A. McVoy, and Laura Hertel. "Human Cytomegalovirus Replication and Infection-Induced Syncytia Formation in Labial, Foreskin, and Fetal Lung Fibroblasts." Viruses 13, no. 12 (2021): 2355. http://dx.doi.org/10.3390/v13122355.

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Only a handful of cell types, including fibroblasts, epithelial, and endothelial cells, can support human cytomegalovirus (CMV) replication in vitro, in striking contrast to the situation in vivo. While the susceptibility of epithelial and endothelial cells to CMV infection is strongly modulated by their anatomical site of origin, multiple CMV strains have been successfully isolated and propagated on fibroblasts derived from different organs. As oral mucosal cells are likely involved in CMV acquisition, we sought to evaluate the ability of infant labial fibroblasts to support CMV replication,

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Trial, JoAnn, and Katarzyna A. Cieslik. "Changes in cardiac resident fibroblast physiology and phenotype in aging." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 4 (2018): H745—H755. http://dx.doi.org/10.1152/ajpheart.00237.2018.

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The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to activate a canonical transforming growth factor-β-Smad pathway and differentiate poorly into contractile myofibroblasts. That results in the formation of an insufficient scar after myocardial infarction. In contrast, in the uninjured aged heart, fibroblasts are activated and acquire a profibrotic phenotype that leads to interstitial fibrosis, ventricular stiffness, and diastolic dysfunction, all conditions that may lead to heart f

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Jara, Paul, Jazmin Calyeca, Yair Romero, et al. "Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 6 (2015): L511—L522. http://dx.doi.org/10.1152/ajplung.00043.2014.

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Idiopathic pulmonary fibrosis (IPF) is a progressive and usually lethal interstitial lung disease of unknown etiology characterized by aberrant activation of epithelial cells that induce the migration, proliferation and activation of fibroblasts. The resulting distinctive fibroblastic/myofibroblastic foci are responsible for the excessive extracellular matrix (ECM) production and abnormal lung remodeling. We have recently found that matrix metalloproteinase 19 (MMP-19)-deficient ( Mmp19−/−) mice develop an exaggerated bleomycin-induced lung fibrosis, but the mechanisms are unclear. In this stu

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McKean, David M., Lila Sisbarro, Dusko Ilic, et al. "FAK induces expression of Prx1 to promote tenascin-C–dependent fibroblast migration." Journal of Cell Biology 161, no. 2 (2003): 393–402. http://dx.doi.org/10.1083/jcb.jcb.200302126.

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Fibroblast migration depends, in part, on activation of FAK and cellular interactions with tenascin-C (TN-C). Consistent with the idea that FAK regulates TN-C, migration-defective FAK-null cells expressed reduced levels of TN-C. Furthermore, expression of FAK in FAK-null fibroblasts induced TN-C, whereas inhibition of FAK activity in FAK–wild-type cells had the opposite effect. Paired-related homeobox 1 (Prx1) encodes a homeobox transcription factor that induces TN-C by interacting with a binding site within the TN-C promoter, and it also promotes fibroblast migration. Therefore, we hypothesiz

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Iwasaki, Kengo, Keiko Akazawa, Mizuki Nagata, et al. "Angiogenic Effects of Secreted Factors from Periodontal Ligament Stem Cells." Dentistry Journal 9, no. 1 (2021): 9. http://dx.doi.org/10.3390/dj9010009.

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Periodontal disease is a chronic inflammation of tooth-supporting tissues, and the destruction of these tissues results in tooth loss. Regeneration of periodontal tissues is the ultimate goal of periodontal treatment. We previously reported that transplantation of conditioned medium (CM) of periodontal ligament stem cells (PDLSCs) demonstrated the enhancement of periodontal tissue regeneration, compared to CM from fibroblasts (Fibroblast-CM). We hypothesized that the angiogenic effects of PDLSC-CM might participate in the enhanced wound healing of periodontal tissues. The aim of this study was

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Ruiz-Camp, Jordi, and Rory E. Morty. "Divergent fibroblast growth factor signaling pathways in lung fibroblast subsets: where do we go from here?" American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 8 (2015): L751—L755. http://dx.doi.org/10.1152/ajplung.00298.2015.

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Lung fibroblasts play a key role in postnatal lung development, namely, the formation of the alveolar gas exchange units, through the process of secondary septation. Although evidence initially highlighted roles for fibroblasts in the production and remodeling of the lung extracellular matrix, more recent studies have described the presence of different fibroblast subsets in the developing lung. These subsets include myofibroblasts and lipofibroblasts and their precursors. These cells are believed to play different roles in alveologenesis and are localized to different regions of the developin

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Bucala, R., C. Ritchlin, R. Winchester, and A. Cerami. "Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts." Journal of Experimental Medicine 173, no. 3 (1991): 569–74. http://dx.doi.org/10.1084/jem.173.3.569.

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Conditioned media obtained from fibroblasts cultured from rheumatoid and certain other inflammatory synovia were observed to stimulate [3H]thymidine incorporation in an indicator murine fibroblast line. Synovial fibroblasts derived from the joints of patients with osteoarthritis did not display this property. This effect persisted in culture for many weeks and occurred in the absence of co-stimulatory immune cells. Antibody neutralization studies implicated a role for basic fibroblast growth factor (bFGF), transforming growth factor beta (TGF-beta), granulocyte/macrophage colony-stimulating fa

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Liao, James, Jabrane Azelmat, Lei Zhao, Masami Yoshioka, Daisuke Hinode, and Daniel Grenier. "The Kampo Medicine Rokumigan Possesses Antibiofilm, Anti-Inflammatory, and Wound Healing Properties." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/436206.

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Periodontal diseases, which are inflammatory diseases of bacterial origin affecting the tooth-supporting tissues, are characterized by inflammation and destruction of gingival connective tissue and alveolar bone, and may lead to tooth loss. The aim of the study was to investigate Rokumigan, a Kampo Japanese traditional medicine made of six different plants, for its capacity to prevent biofilm formation byFusobacterium nucleatum, to inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion by mucosal cells, and to promote wound healing in a fibroblast model. Using a microplate colorimetri

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Ariesanti, Yessy, Irvan Septrian Syah Putra Rasad, Maylan Nimas, and Nadira Syabilla. "The effect of Persea americana Mill. seed extract on inflammatory cells and fibroblast formation in tooth extraction socket healing." Dental Journal (Majalah Kedokteran Gigi) 54, no. 4 (2021): 190. http://dx.doi.org/10.20473/j.djmkg.v54.i4.p190-194.

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Background: Inflammatory cells and fibroblasts have an essential role in the wound healing process. Persea americana Mill. seed categorises as a waste; it contains rich nutrients that can accelerate wound healing activity. Purpose: This study aims to determine the effect of Persea americana Mill. seed against inflammatory cells and fibroblast formation in tooth extraction socket healing. Methods: Ninety-six Sprague Dawley rats had their lower left molars removed. Forty-eight rats tested for inflammatory cells were divided into four groups: negative control group (IC1), positive control group (

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Fadeyev, F. A., Yu Ya Khrunyk, S. V. Belikov, et al. "The adhesion of human dermal fibroblasts on anodized nanotube-layered titanium, modified for implantology application." Доклады Академии наук 486, no. 1 (2019): 123–26. http://dx.doi.org/10.31857/s0869-56524861123-126.

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Anodization of titanium implants is accompanied by the formation of titanium oxide nanotubes improving osseointegration. An excessive fibroblast adhesion on the surface might lead to the formation of fibrous capsule resulting in implant rejection. In our research, we demonstrated that the adhesion activity of human dermal fibroblasts on anodized surface was not elevated, which is promising for the use of titanium with nanotube-layered surface for implantology.

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Kim, So Hee, Bokyung Kim, Jung Hak Kim, et al. "L-myc Gene Expression in Canine Fetal Fibroblasts Promotes Self-Renewal Capacity but Not Tumor Formation." Cells 10, no. 8 (2021): 1980. http://dx.doi.org/10.3390/cells10081980.

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Canines are useful in mammalian preclinical studies because they are larger than rodents and share many diseases with humans. Canine fetal fibroblast cells (CFFs) are an easily accessible source of somatic cells. However, they are easily driven to senescence and become unusable with continuous in vitro culture. Therefore, to overcome these deficiencies, we investigated whether tetracycline-inducible L-myc gene expression promotes self-renewal activity and tumorigenicity in the production of induced conditional self-renewing fibroblast cells (iCSFCs). Here, we describe the characterization of a

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Zucali, J. R., H. E. Broxmeyer, M. A. Gross, and C. A. Dinarello. "Recombinant human tumor necrosis factors alpha and beta stimulate fibroblasts to produce hemopoietic growth factors in vitro." Journal of Immunology 140, no. 3 (1988): 840–44. http://dx.doi.org/10.4049/jimmunol.140.3.840.

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Abstract The influences of TNF alpha and TNF beta were evaluated for their stimulatory and inhibitory effects on in vitro colony formation by human bone marrow granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells. Both TNF alpha and TNF beta induced fibroblasts to produce stimulators of CFU-GM, BFU-E, and CFU-GEMM in a dose-dependent fashion. Similar results were seen when equivalent concentrations of TNF alpha and TNF beta were used. Prior incubation of the TNF alpha and TNF beta with their respective antibodies inactivated the ability of the TNF

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Chen, Hsuan-Yu, Tzu-Chieh Lin, Chih-Yung Chiang, et al. "Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy." Polymers 13, no. 13 (2021): 2129. http://dx.doi.org/10.3390/polym13132129.

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The application of antifibrotic materials can alleviate epidural fibrosis by restricting excessive fibroblast proliferation and mitigating scar tissue formation. Here, a biodegradable carboxymethyl cellulose (CMC)-Bletilla striata polysaccharide (BSP)-resveratrol (RES) sponge was fabricated to inhibit scar tissue formation post laminectomy surgery. Fibroblasts NIH/3T3, myoblasts C2C12, neural cells PC-12, and Schwann cells RSC96 were used to evaluate the in vitro cytocompatibility. Laminectomies on 10 Sprague–Dawley rats with/without the application of the CMC-BSP-RES sponge were performed. Th

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Tang, Zhiming, Yi Cao, Jicun Ding, et al. "Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway." BioMed Research International 2020 (September 30, 2020): 1–10. http://dx.doi.org/10.1155/2020/3608372.

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Background. Wubeizi (Rhus chinensis Mill.) ointment has been shown as an effective treatment for keloids. However, the protective mechanisms of Wubeizi ointment are not fully understood. The mammalian target of rapamycin (mTOR) has been demonstrated to be associated with keloid pathogenesis. In the present study, we investigated if Wubeizi ointment suppressed keloid formation through the modulation of key molecules of the rapamycin (mTOR) pathway including phosphatase and tensin homolog (PTEN), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt). Methods. A keloid mouse model and

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Kelley, J., J. P. Fabisiak, K. Hawes, and M. Absher. "Cytokine signaling in lung: transforming growth factor-beta secretion by lung fibroblasts." American Journal of Physiology-Lung Cellular and Molecular Physiology 260, no. 2 (1991): L123—L128. http://dx.doi.org/10.1152/ajplung.1991.260.2.l123.

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Control of growth and phenotypic expression of interstitial fibroblasts is a critical determinant of lung architecture and physiology during processes of growth and remodeling. We examined the ability of lung fibroblasts to produce transforming growth factor-beta (TGF-beta), a cytokine that is known to modulate proliferation and phenotypic expression of mesenchymal cells. Cultures of fibroblasts isolated from rat lungs spontaneously secrete TGF-beta as measured in the standard bioassay of anchorage-independent growth of normal rat kidney (NRK) cells in soft agar. Rat lung fibroblasts secrete T

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Soriano, J. V., M. S. Pepper, T. Nakamura, L. Orci, and R. Montesano. "Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells." Journal of Cell Science 108, no. 2 (1995): 413–30. http://dx.doi.org/10.1242/jcs.108.2.413.

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Although epithelial-mesenchymal (stromal) interactions are thought to play an important role in embryonic and postnatal development of the mammary gland, the underlying mechanisms are still poorly understood. To address this issue, we assessed the effect of fibroblast-derived diffusible factors on the growth and morphogenetic properties of a clonally derived subpopulation (clone TAC-2) of normal murine mammary gland (NMuMG) epithelial cells embedded in collagen gels. Under control conditions, TAC-2 mammary gland epithelial cells suspended within collagen gels formed either irregularly shaped c

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Sanderson, R. D., J. M. Fitch, T. R. Linsenmayer, and R. Mayne. "Fibroblasts promote the formation of a continuous basal lamina during myogenesis in vitro." Journal of Cell Biology 102, no. 3 (1986): 740–47. http://dx.doi.org/10.1083/jcb.102.3.740.

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Analyses were made of the requirements for the formation of a continuous basal lamina during myogenesis of quail muscle in vitro. A culture system was developed in which mass cultures of differentiating muscle cells were embedded in a native gel of rat tail collagen. Fibroblastic cells, which were also present in the cultures, migrated into the gel and within a few days surrounded the newly formed myotubes. In this environment, a continuous basal lamina was formed at the surface of the myotubes as demonstrated by immunofluorescent staining with monoclonal antibodies against type IV collagen, l

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Nguyentu, Trina T., Danielle G. Vigilante, Mishika Manchanda, Meera S. Iyer, Sara Desalegne, and Joseph J. Provost. "Identifying a Role for the Sodium Hydrogen Exchanger Isoform 1 in Idiopathic Pulmonary Fibrosis: A Potential Strategy to Modulate Profibrotic Pathways." Biomedicines 13, no. 4 (2025): 959. https://doi.org/10.3390/biomedicines13040959.

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Background/Objectives: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by excessive extracellular matrix (ECM) production and tissue stiffening, resulting in impaired lung function. Sodium hydrogen exchanger isoform 1 (NHE1) is a key mediator of intracellular and extracellular pH regulation, influencing fibroblast activation, motility, and proliferative pathways. This study investigates the role of NHE1 in actin stress fiber formation, fibroblast-to-myofibroblast differentiation, and cytokine secretion in IPF progression. Methods: Fibroblasts were treated with profi

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Sokolova, T. F., S. V. Skal’skiy, and N. E. Turok. "Evaluation of the possibility to use calcium channel blockers for prevention of intra-abdominal adhesions formation." Kazan medical journal 98, no. 2 (2017): 218–21. http://dx.doi.org/10.17750/kmj2017-218.

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Aim. To study the possibility of the use of known medications used in cardiology - calcium channel blockers - derivatives of phenylalkilamine (verapamil), benzodiazepine (diltiazem), dihydropyridine (nifedipine) - for prevention of peritoneal adhesion formation.  Methods. The study of the effect of different concentrations of medications on nuclear translocation of NF-κB, proliferative and collagen-synthetic activity of fibroblasts was conducted in the primary culture of rats peritoneal fibroblasts with hemoperitoneum. Aseptic injury of peritoneum was caused by modeling of autohemoperito

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Zhang, Yihe, Bingjie Jiang, and Meng Huee Lee. "A Novel 3D Model for Visualization and Tracking of Fibroblast-Guided Directional Cancer Cell Migration." Biology 9, no. 10 (2020): 328. http://dx.doi.org/10.3390/biology9100328.

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Stromal fibroblasts surrounding cancer cells are a major and important constituent of the tumor microenvironment not least because they contain cancer-associated fibroblasts, a unique fibroblastic cell type that promotes tumorigenicity through extracellular matrix remodeling and secretion of soluble factors that stimulate cell differentiation and invasion. Despite much progress made in understanding the molecular mechanisms that underpin fibroblast–tumor cross-talk, relatively little is known about the way the two cell types interact from a physical contact perspective. In this study, we repor

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Salas-Oropeza, Judith, Marco Aurelio Rodriguez-Monroy, Manuel Jimenez-Estrada, et al. "Essential Oil of Bursera morelensis Promotes Cell Migration on Fibroblasts: In Vitro Assays." Molecules 28, no. 17 (2023): 6258. http://dx.doi.org/10.3390/molecules28176258.

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Essential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of Bursera morelensis, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect of this EO on fibroblast migration in a three-dimensional in vitro model. For the three-dimensional in vitro model, a series of fibrin hydrogel scaffolds (FSs) were built in which fibroblasts were cultured and subsequently stimulated with fibroblast growth factor (FGF) or EO. The results demonstrated that these FSs ar

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Strell, Carina, Janna Paulsson, Shao-Bo Jin, et al. "Impact of Epithelial–Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ." JNCI: Journal of the National Cancer Institute 111, no. 9 (2019): 983–95. http://dx.doi.org/10.1093/jnci/djy234.

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AbstractBackgroundA better definition of biomarkers and biological processes related to local recurrence and disease progression is highly warranted for ductal breast carcinoma in situ (DCIS). Stromal–epithelial interactions are likely of major importance for the biological, clinical, and pathological distinctions between high- and low-risk DCIS cases.MethodsStromal platelet derived growth factor receptor (PDGFR) was immunohistochemically assessed in two DCIS patient cohorts (n = 458 and n = 80). Cox proportional hazards models were used to calculate the hazard ratios of recurrence. The molecu

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Mello, Ashley M., Tenzin Ngodup, Yusoo Lee, et al. "Abstract PR03: Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer." Cancer Immunology Research 11, no. 12_Supplement (2023): PR03. http://dx.doi.org/10.1158/2326-6074.tumimm23-pr03.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple deadly cancers, it has been largely ineffective in PDAC. This lack of response is in part attributed to its extensive, fibroinflammatory stroma and hypoxic microenvironment. Cancer-associated fibroblasts (CAFs) are a predominant and heterogeneous stromal cell type in PDAC, and single-cell transcriptomics of human and mouse PDAC has recently revealed a distinct CAF subpopulation, inflammatory CAFs (iCAFs

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Sun, Liguo, Ling Qu, Rui Zhu, et al. "Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast." Stem Cells International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/9842075.

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Mesenchymal stem cells (MSCs) and fibroblasts are two major seed cells for ligament tissue engineering. To understand the effects of mechanical stimulation on these cells and to develop effective approaches for cell therapy, it is necessary to investigate the biological effects of various mechanical loading conditions on cells. In this study, fibroblasts and MSCs were tested and compared under a novel Uniflex/Bioflex culture system that might mimic mechanical strain in ligament tissue. The cells were uniaxially or radially stretched with different strains (5%, 10%, and 15%) at 0.1, 0.5, and 1.

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Muhammad Fajrin Wijaya, Aditya H. Asmara, Indrya Kirana Mattulada, Andy Fairuz Zuraida Eva, and Andi Fajrin Perdana Sam. "Efektivitas Bahan Alami dalam Meningkatkan Jumlah Sel Fibroblas pada Soket Gigi Tikus Wistar Setelah Pencabutan Gigi." Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan 3, no. 1 (2025): 97–111. https://doi.org/10.61132/corona.v3i1.1079.

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The healing process of a tooth socket after extraction involves various stages, including the proliferation of fibroblasts that play a role in the formation of new tissue. Natural ingredients have long been used in accelerating wound healing, but their effectiveness in increasing the number of fibroblast cells still needs to be studied further. To determine the effectiveness of natural ingredients in increasing the number of fibroblast cells in the tooth socket of Wistar rats after tooth extraction. Methods: This is a literature review that collects and analyzes scientific articles from variou

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Yang, Fengchun, Clegg Travis, Shi Chen, et al. "Murine and Human NF1 Haploinsufficient Mast Cells Promote Alterations in Fibroblast Function and Organization of the Extracellular Matrix in Three-Dimensional Collagen Lattices and this Gain in Function Is Abrogated by the Addition of STI-571." Blood 104, no. 11 (2004): 1465. http://dx.doi.org/10.1182/blood.v104.11.1465.1465.

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Abstract Cutaneous neurofibromas are a hallmark of neurofibromatosis type 1 (NF1), a common genetic disorder that is caused by mutations in the NF1 gene, which functions as a GAP for p21ras. Though the pathogenesis of neurofibroma formation is not completely known, haploinsufficiency of the nonneuronal lineages (fibroblasts, mast cells and endothelial cells) in the tumor microenvironment are required for neurofibroma formation (Zhu, Science 2002). These tumors are characterized by a high concentration of degranulating mast cells (MC) closely associated with fibroblasts, endothelial cells and S

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Willenborg, Sebastian, Katrin Schönborn, Mugdha Sawant та ін. "Fibroblast‐Derived TGFβ1 Regulates Skin Repair and Fibrosis". Wound Repair and Regeneration 33, № 4 (2025). https://doi.org/10.1111/wrr.70065.

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ABSTRACTActivation of fibroblasts and formation of myofibroblasts are essential for granulation tissue formation following injury. In fibrotic reactions, excessive deposition of ECM by the activated fibroblasts determines scar formation and functional failure. Although these events critically depend on the activity of a plethora of growth factors and cytokines, TGFβ1 is a unique player controlling the immune response and proliferation of many cell types. Different cell types contribute to its release and activation, which is also regulated by the interaction with the ECM and by mechanical forc

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Wang, Shao-Ming, Jung-Yu C. Hsu, Chiung-Yuan Ko, Hsiang-En Wu, Yu-Wei Hsiao, and Ju-Ming Wang. "Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury." Molecular Neurobiology, January 12, 2023. http://dx.doi.org/10.1007/s12035-023-03207-z.

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AbstractAstroglial-fibrotic scars resulted from spinal cord injury affect motor and sensory function, leading to paralysis. In particular, the fibrotic scar is a main barrier that disrupts neuronal regeneration after spinal cord injury. However, the association between astrocytes and fibrotic scar formation is not yet understood. We have previously demonstrated that the transcriptional factor Cebpd contributes to astrogliosis, which promotes glial scar formation after spinal cord injury. Herein, we show that fibrotic scar formation was decreased in the epicenter region in Cebpd−/− mice after c

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