Academic literature on the topic 'Fibroblastic'

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Journal articles on the topic "Fibroblastic"

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Plaisancié, Pascale, Charline Buisson, Edwin Fouché, et al. "Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture." PLOS ONE 17, no. 8 (2022): e0273858. http://dx.doi.org/10.1371/journal.pone.0273858.

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Continuous and rapid renewal of the colonic epithelium is crucial to resist the plethora of luminal deleterious agents. Subepithelial fibroblasts contribute to this turnover by regulating epithelial proliferation and differentiation. However, when intestinal homeostasis is disturbed, fibroblasts can acquire an activated phenotype and play a major role in the progression of intestinal pathologies. To evaluate the involvement of fibroblasts in the regulation of colonocytes under homeostatic or pathological conditions, we established resting and activated conditionally immortalized fibroblast cel
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Bouziges, F., P. Simon-Assmann, C. Leberquier, K. Haffen, and M. Kedinger. "Glycosaminoglycan expression in intestinal epithelial skin-fibroblastic cell cocultures. Fibroblastic cell-mediated effects of glucocorticoids." Journal of Cell Science 92, no. 4 (1989): 679–85. http://dx.doi.org/10.1242/jcs.92.4.679.

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The nature and distribution of newly synthesized glycosaminoglycans (GAGs) were studied in foetal rat skin fibroblasts, in rat intestinal endodermal cells and in cocultures of both cell types. The data show that fibroblasts synthesize and secrete hyaluronic acid (HA), heparan sulphate (HS) and chondroitin sulphate molecules (CS). Our data focus on HA, which is found as two different molecular forms, the smallest hydrodynamic-sized species being mostly recovered within the cell or associated with the cell surface, and the largest one secreted into the medium, whatever the cell type. Endodermal
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Heng, Madalene. "Phosphorylase Kinase Inhibition Therapy in Burns and Scalds." BioDiscovery 20 (February 24, 2017): e11207. https://doi.org/10.3897/biodiscovery.20.e11207.

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Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblas
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Kim, Hyun-Jin, Seong-Min Kim, Min-Jeong Choi та Young-Joo Jang. "Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-β1-Induced Periodontal Ligament-Fibroblastic Differentiation". Stem Cells International 2022 (16 липня 2022): 1–15. http://dx.doi.org/10.1155/2022/3273779.

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Human periodontal ligament stem cells (hPDLSCs) can be differentiated into periodontal ligament- (PDL-) fibroblastic progenitors by treatment with low concentrations of transforming growth factor beta 1 (TGF-β1). Although much is known about the profibrotic effects of TGF-β1, the molecular mechanisms mediating the activation of fibroblasts in periodontal ligament-fibroblastic differentiation are not well known. Our study was to investigate the mechanism of the fibroblastic process in the periodontal ligament differentiation of hPDLSCs through the discovery of novel markers. One of the monoclon
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Lupu, Florea, Robert Silasi-Mansat, Ravi Keshari, et al. "Persistent inflammation and fibrosis of the lung are long-term complications of sepsis in baboons (P4015)." Journal of Immunology 190, no. 1_Supplement (2013): 131.8. http://dx.doi.org/10.4049/jimmunol.190.supp.131.8.

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Abstract Sepsis-induced inflammation of the lung leads to acute respiratory distress syndrome (ARDS), which may trigger persistent fibrotic responses. We have developed a baboon model of E. coli sepsis-induced ARDS and characterized the long-term (6-24 months) effects of sepsis on the lung. By immunocytochemistry, we detected focal accumulation of neutrophils, M2 macrophages, IL17 and TGF-β positive cells, which indicates persistent inflammation in the lung, months after clinical recovery from the acute sepsis episode. Microscopical and biochemical quantification demonstrated an almost doublin
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Roy, Bibhas, Luezhen Yuan, Yaelim Lee, Aradhana Bharti, Aninda Mitra, and G. V. Shivashankar. "Fibroblast rejuvenation by mechanical reprogramming and redifferentiation." Proceedings of the National Academy of Sciences 117, no. 19 (2020): 10131–41. http://dx.doi.org/10.1073/pnas.1911497117.

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Over the course of the aging process, fibroblasts lose contractility, leading to reduced connective-tissue stiffness. A promising therapeutic avenue for functional rejuvenation of connective tissue is reprogrammed fibroblast replacement, although major hurdles still remain. Toward this, we recently demonstrated that the laterally confined growth of fibroblasts on micropatterned substrates induces stem-cell-like spheroids. In this study, we embedded these partially reprogrammed spheroids in collagen-I matrices of varying densities, mimicking different three-dimensional (3D) tissue constraints.
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Bronson, R. E., J. A. Treat, and C. N. Bertolamp. "Fibroblastic Subpopulations in Uninjured and Wounded Rabbit Oral Mucosa." Journal of Dental Research 68, no. 1 (1989): 51–58. http://dx.doi.org/10.1177/00220345890680010801.

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Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamine into GAG in cellular, pericellular, and medium fractions, with the majority of incorporated label residing in the medium. Dermatan sulfate (DS) was the predominant GAG in the medium fraction of both normal and wound fibroblast cultures; however, the two cell lines differed in th
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Cai, Zhou, Hua Guo, Jing Qian та ін. "Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway". PeerJ 10 (27 липня 2022): e13775. http://dx.doi.org/10.7717/peerj.13775.

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Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”. Aberrant activation of TGF-β1 is frequently encountered and promotes fibroblast proliferation, activation, and differentiation in pulmonary fibrosis. Hence, the inhibition of TGF-β1-induced lung fibroblast activation holds promise as a therapeutic strategy for IPF. The present study aimed to investigate the potential effect and underlying mechanisms of bone morphogenetic prote
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Douillet, Camille, Marc Nicodeme, Loïc Hermant, et al. "From local to global matrix organization by fibroblasts: a 4D laser-assisted bioprinting approach." Biofabrication 14, no. 2 (2022): 025006. http://dx.doi.org/10.1088/1758-5090/ac40ed.

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Abstract Fibroblasts and myofibroblasts play a central role in skin homeostasis through dermal organization and maintenance. Nonetheless, the dynamic interactions between (myo)fibroblasts and the extracellular matrix (ECM) remain poorly exploited in skin repair strategies. Indeed, there is still an unmet need for soft tissue models allowing to study the spatial-temporal remodeling properties of (myo)fibroblasts. In vivo, wound healing studies in animals are limited by species specificity. In vitro, most models rely on collagen gels reorganized by randomly distributed fibroblasts. But biofabric
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Cadosch, Nadine, Cristina Gil-Cruz, Christian Perez-Shibayama, and Burkhard Ludewig. "Cardiac Fibroblastic Niches in Homeostasis and Inflammation." Circulation Research 134, no. 12 (2024): 1703–17. http://dx.doi.org/10.1161/circresaha.124.323892.

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Fibroblasts are essential for building and maintaining the structural integrity of all organs. Moreover, fibroblasts can acquire an inflammatory phenotype to accommodate immune cells in specific niches and to provide migration, differentiation, and growth factors. In the heart, balancing of fibroblast activity is critical for cardiac homeostasis and optimal organ function during inflammation. Fibroblasts sustain cardiac homeostasis by generating local niche environments that support housekeeping functions and by actively engaging in intercellular cross talk. During inflammatory perturbations,
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Dissertations / Theses on the topic "Fibroblastic"

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Pelon, Floriane. "Fibroblastic heterogeneity and metastatic spread in breast cancers Fibroblast heterogeneity drives metastatic spread in breast cancer through distinct mechanisms." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2392&f=17330.

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Les cancers du sein, premiers cancers féminins et causes aujourd’hui encore de nombreux décès, sont classés en 3 sous-types moléculaires : luminaux –les plus répandus, HER2 et triple-négatifs (TN) –les plus agressifs. Lors du diagnostic, l’envahissement des ganglions lymphatiques axillaires par les cellules tumorales est établi. Il s’agit, en plus de la classification moléculaire, d’un marqueur pronostique utilisé en clinique pour stratifier les patientes, car il informe sur le risque de développement ultérieur de métastases, cause majeure des décès à l’heure actuelle. Les tumeurs solides, et
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Simpson, Russell Michael Lloyd. "Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55467/.

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Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly.
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Thompson, Joyce K. "The Role of Inflammasomes in Asbestos-Induced Mesothelial to Fibroblastic Transition." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/691.

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Malignant Mesothelioma (MM) is a fatal disease with a low median survival between 8 to 12 months after diagnosis. MM has a long latency period (10-60 years), is causally related to asbestos exposure, and is refractory to all available modes of therapy. Despite the causal association between asbestos exposure and MM however, the mechanisms by which asbestos induces this deadly disease remain unclear. Chronic inflammation due to the presence of asbestos fibers is believed to play an important role in all aspects of MM pathogenesis, from development to progression and resistance. Chronic inflamma
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Desai, Chandni. "Retrospective histopathologic evaluation of fibroblastic versus myofibroblastic entities of the oral mucosa." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/6094.

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The objective of this study is to use immunohistochemistry to determine whether myofibroma is a distinct entity or a variation of other fibroblastic entities. Staining patterns of vimentin, SMA and CD34 are evaluated in irritation fibromas, ulcerated fibromas, giant cell fibromas, inflammatory fibrous hyperplasias, focal keratosis and chronic mucositis, used in this study as a control group, and myofibromas. This study assesses whether myofibromas demonstrate similar staining patterns of vimentin, SMA and CD34 to the aforementioned lesions and if these stains are adequate in differentiating th
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Refaei, Mohammad. "Characterization of endocytic recycling and sorting of glycosylphosphatidylinositol-anchored proteins in fibroblastic cell lines." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95126.

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The majority of glycosylphosphatidylinositol (GPI)-anchored proteins enter mammalian cells via the clathrin-, and dynamin-independent GPI-enriched early endosomal compartment/ Clathrin-independent carrier endocytic (GEEC/ CLIC) pathway. Using artificially lipid-anchored proteins, we have examined how the ‘anchor' structure of these proteins affects their endocytic trafficking after initial internalization from the plasma membrane. In the first part of this thesis, I show that soluble proteins, anchored to cell-inserted saturated and unsaturated phosphatidylethanolamine (PE)-polyethylene glycol
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Lanser, Brittany. "Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2012, 2012. http://hdl.handle.net/10133/3390.

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This thesis reports that checkpoint adaptation occurs in human brain cancer cells. M059K cells, after treatment with camptothecin (CPT), recruited γ-histone H2AX, phosphorylated Chk1 and arrested in the G2 phase. Strikingly, cells escaped the checkpoint, became rounded and entered mitosis as measured by phospho-histone H3 signals. Lamin A/C immunofluorescence microscopy revealed that 48% of the cells that survived checkpoint adaptation contained micronuclei. These data suggest that brain cancer cells undergo checkpoint adaptation and may have an altered genome. This thesis also explored if pho
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Jordan, Grant R. "Regulation of the proliferation and osteogenic differentiation of colony forming units-fibroblastic derived from human bone marrow." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323593.

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GAGLIO, DANIELA. "Role of nutrient availability on proliferation and cell cycle excution of immortalized and kras transformed mouse fibroblastic." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7548.

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Mammalian cells proliferate, differentiate or die in response to extracellular signals as growth factors and nutrients. Cancer is essentially a disease in which cells have lost responsiveness to many of these signals and to normal checks on cell proliferation. Therefore, it may not be surprising that tumor cells, in order to meet the increased requirements of proliferation, often display fundamental changes in pathways of energy metabolism and nutrient uptake (Garber, 2006). In particular, several studies shown that the process of tumorigenesis is often associated with altered metabolism of tw
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Woodruff, Matthew Charles. "Structure and Function of the Murine Lymph Node." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13102331.

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Lymph nodes (LNs) are dynamic organs responsible for providing a supportive and centralized environment for the generation of immune response. Utilizing a highly organized network of non-hematopoietic stromal cells, the LN serves as the context in which the immune system collects and presents antigen, promotes innate and adaptive immune interaction, and generates protective cell-mediated and humoral immunity. In this way, proper organization and function of the LN environment is a critical component of effective immunity, and understanding its complexity has direct impact on the ability to gen
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ASAI, JUNPEI, and ABU ABED Y. MOHAMMAD. "Ultrastructural and Morphometrical Studies on the Reticular Framework and Reticular Fibers in the Reticuloendothelial System of Rats." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17531.

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Books on the topic "Fibroblastic"

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P, Phipps Richard, ed. Pulmonary fibroblast heterogeneity. CRC Press, 1992.

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Turner, Neil A. The cardiac fibroblast. Research Signpost, 2011.

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Sayers, Nicola MacDonald. Fibroblast-endothelial cell interaction. University of Manchester, 1993.

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David, Evered, Whelan Julie, Ciba Foundation, and Symposium on Fibrosis (1984 : Ciba Foundation), eds. Fibrosis. Pitman, 1985.

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Symposium on Fibrosis (1984 : London), ed. Fibrosis. Pitman, 1985.

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Kulkarni, Gajanan Vishwanath. Regulation of apoptosis in fibroblasts. University of Toronto, Faculty of Dentistry], 1996.

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Milo, George E., and Bruce C. Casto. Transformation of Human Diploid Fibroblasts. CRC Press, 2024. https://doi.org/10.1201/9781003574415.

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Burgar, Helen Rachel. Fibroblast growth factor receptor signalling. University of Birmingham, 2002.

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Baird, Andrew, 1954 July 27-, Klagsbrun Michael, and New York Academy of Sciences., eds. The Fibroblast growth factor family. New York Academy of Sciences, 1991.

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Walters, Jean Elizabeth. Immunochemical studies on fibroblast growth factor-1 and fibroblast growth factor receptor 1. Oxford Brookes University, 1998.

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Book chapters on the topic "Fibroblastic"

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Nerede, Helin, and Menduh Oruc. "Aspiration Pneumonia in Children." In Pediatric Chest Infection. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359463.14.

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Idiopathic pulmonary fibrosis is characterized by an aberrant wound healing response following lung injury, leading to excessive fibroblast proliferation and extracellular matrix deposition. Fibroblasts and myofibroblasts play a central role in the disease process. They proliferate abnormally and produce collagen and other matrix proteins, resulting in fibrosis. Epithelial-mesenchymal transition where epithelial cells transform into mesenchymal cells, contributes to the pool of fibroblasts in the fibrotic lung. Mutations in genes related to telomere maintenance (TERT, TERC) and surfactant prot
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Mazabraud, André. "Fibroblastic sarcoma." In Pathology of bone tumours. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-95839-7_17.

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Mocellin, Simone. "Myxoinflammatory Fibroblastic Sarcoma." In Soft Tissue Tumors. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-58710-9_183.

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Perry, Kyle. "Fibroblastic/Myofibroblastic Tumors." In Soft Tissue Pathology for Clinicians. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55654-3_5.

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Fritchie, Karen. "Myxoinflammatory Fibroblastic Sarcoma." In Encyclopedia of Pathology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-28845-1_5432-1.

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Kang, Heung Sik, Sung Hwan Hong, Ja-Young Choi, and Hye Jin Yoo. "Fibroblastic/Myofibroblastic Tumors." In Oncologic Imaging: Soft Tissue Tumors. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-287-718-5_5.

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Picci, Piero, Angelo Paolo Dei Tos, Marco Gambarotti, and Alberto Righi. "Fibroblastic/Myofibroblastic Tumors." In Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-29676-6_42.

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Vandevenne, Jan E., and Arthur M. De Schepper. "Fibroblastic/Myofibroblastic Tumors." In Imaging of Soft Tissue Tumors. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46679-8_13.

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Olcay, Mahmut. "Viral Pneumonia in Children." In Pediatric Chest Infection. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359463.15.

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Abnormal wound healing of idiopathic pulmonary fibrosis is characterized by an inappropriate wound healing response following lung injury, leading to excessive proliferation of fibroblasts and deposition of extracellular matrix proteins. Fibroblasts and myofibroblasts are central players in the fibrotic process, these cells proliferate and produce large amounts of collagen and other matrix components, contributing to the stiffening of lung tissue. Epithelial-mesenchymal transition of epithelial cells transform into mesenchymal cells, adding to the fibroblast population and promoting fibrosis.
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Fisher, Cyril. "Benign Fibroblastic and Myofibroblastic Lesions." In Atlas of Soft Tissue Tumor Pathology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7025-0_3.

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Conference papers on the topic "Fibroblastic"

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SILVA, CAMILLA DE CASTRO E., CAMILA PITASI ARGUELHES, VICTOR REBELLO VERTZMAN, et al. "FIBROBLASTIC RHEUMATISM: A CASE REPORT." In 36º Congresso Brasileiro de Reumatologia. Editora Blucher, 2019. http://dx.doi.org/10.5151/sbr2019-103.

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Torres, J. J. "Modelling Action Potential Generation and Propagation in Fibroblastic Cells." In MODELING OF COMPLEX SYSTEMS: Seventh Granada Lectures. AIP, 2003. http://dx.doi.org/10.1063/1.1571357.

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Tong, Zhixiang, and Xinqiao Jia. "Vocal fold-mimetic environment for fibroblastic differentiation of mesenchymal stem cell." In 2012 38th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2012. http://dx.doi.org/10.1109/nebc.2012.6207138.

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Corbella, Dr Carolina Calvo, Dr Sergio Gutierrez Salazar, Dr Macarena Boiza Sánchez, and José Serrano Montilla. "A Picture Gallery of Fibroblastic and Myofibroblastic Tumors with Pathologic Correlation." In 30th Annual Scientific Meeting of the European Society of Musculoskeletal Radiology (ESSR). Thieme Medical Publishers, Inc., 2023. http://dx.doi.org/10.1055/s-0043-1770043.

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Lee, Chang H., Eduardo K. Moioli, and Jeremy J. Mao. "Fibroblastic Differentiation of Human Mesenchymal Stem Cells using Connective Tissue Growth Factor." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.259866.

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Lee, Chang H., Eduardo K. Moioli, and Jeremy J. Mao. "Fibroblastic Differentiation of Human Mesenchymal Stem Cells using Connective Tissue Growth Factor." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4397516.

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Fabro, A. T., S. S. Batah, M. Alda, et al. "Airway-Centered Fibroblastic Foci Contributes to Differential Diagnosis of Bronchiolocentric Interstitial Pneumonitis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4959.

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Farkas, L., D. Farkas, J. Gauldie, M. Inman, W. Shi, and M. Kolb. "BMP-Antagonist Gremlin Induces Fibroblastic Foci through EMT in the Rodent Lung." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5390.

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Irene, Gomez, Martin Paloma, Herrera Mercedes, et al. "Abstract 1298:TWIST1is expressed by cells with fibroblastic phenotype in colon carcinoma." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1298.

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Check, Jerome H., Diane Check, Trina Poretta, James Aikins, and Carrie Wilson. "Abstract 696: Palliative benefits of oral mifepristone treatment for metastatic fibroblastic osteosarcoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-696.

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Reports on the topic "Fibroblastic"

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อิศรเสนา ณ อยุธยา, นิพัญจน์, та ศักนัน พงศ์พันธุ์ผู้ภักดี. โครงการ การเปลี่ยนเซลล์ร่างกายปกติเป็นเซลล์ประสาทชนิดจำเพาะโดยจรงด้วยโปรตีนและ RNA : รายงานประจำปี 2555. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.13.

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โรคที่เกิดจากความผิดปกติของระบบประสารทเป็นหนึ่งในปัญหาทางสาธารณสุขที่สำคัญ มีประชากรทั่วโลกกว่าหนึ่งร้อยล้านคนที่ประสบปัญหาและส่วนใหญ่ก็ไม่สามารถรักษาให้หายขาดได้ การปลูกถ่ายเซลล์ประสารทเป็นความหวังหนึ่งที่จะสามารถนำมารักษาผู้ป่วยได้ เช่นในผู้ป่วยที่เป็นโรคพาร์กินสัน การสร้างเซลล์ประสาทชนิดโดพามิเนอร์จิก (dopaminergic neuron) ที่มีความจำเพาะต่อผู้ป่วยนั้นมีศักยภาพที่จะเป็นแหล่งของเซลล์เพื่อนำมาใช้รักษาผู้ป่วยได้ ในการศึกษาครั้งนี้ ทางกลุ่มวิจัยมีวัตถุประสงค์เพื่อสร้างเซลล์ประสาทชนิดโดพามิเนอร์จิกโดยตรงจากเซลล์ dermal fibroblasts และ patient specific induced pluripotent stem cells (psiPSCs) ของ
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Torrungruang, Kitti, and Suchada Chutimawarapun. Antimicrobial activity against periodontopathic bacteria, cell toxicity against gingival fibroblasts and antinflammatory effect of crude extract from mangosteen. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.15.

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Extract from mangosteen pericarp has demonstrated various pharmacological activities including anti-bacterial, anti-inflammatory and anti-fungal. It may have potential for the treatment of periodontal disease, which is a chronic inflammatory disease caused by anaerobic bacteria. The aim of this study was 1) to investigate the toxicity of mangosteen extract to human gingival fibroblast, 2) to examine the anti-bacterial activity of the extract against periodontopathic bacteria including P. gingivalis and A. actinomycetemcomitans, and 3) to examine the inhibitory effect of the extract on PGE[subs
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Techakumphu, Mongkol, Pranee Numchaisrika, Ratajuk Rungsiwiwat, Somchai Suwajanakorn, Kamtorn Pruksananonda, and Pramuan Virutamasen. Development of somatic cell nuclear transfer techique for biomedical and agricultural research : report. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.85.

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To develop somatic cell nuclear transfer by using the rabbit as a mode in biomedical and agricultural research. The experiments are described in nine chapters: Chapter 1: Introduction, Chapter 2: Superovulation and oocyte recipient production in rabbits, Chapter 3: A technique for adult and foetal fibroblast cell culture, for donor cell preparation in somatic nuclear transfer, Chapter 4: Preliminary studies on somatic cell nuclear transfer in rabbits, Chapter 5: In vitro development of rabbit cloned embryos using adult fibroblast cells, after post-activation treatment with cyelohexamide and 6-
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Welling, Bradley. Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada591173.

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ลิขิตวิทยาวุฒิ, กิตติศักดิ์. ชุดโครงการวิจัย การพัฒนาสารต้าน HIV และผลิตภัณฑ์เครื่องสำอางจากมะหาด : รายงานการวิจัย. ภาควิชาเภสัชเวท คณะเภสัชศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2007. https://doi.org/10.58837/chula.res.2007.32.

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ชุดโครงการวิจัยนี้ประกอบด้วยโครงการวิจัย 4 โครงการ โดยมีวัตถุประสงค์หลักคือ (1) พัฒนาวิธีสกัดสาร oxyresveratrol จากแก่นมะหาด (2) จัดทำข้อกำหนดทางเภสัชเวทของมะหาด (3) ดัดแปลงโครงสร้างออกซิเรสเวอราทรอลเพื่อมีฤทธิ์ต้าน HIV สูงขึ้น และ (4) ศึกษาสารสกัดแก่นมะหาดในแง่ฤทธิ์ต้านออกซิเดชัน ผลต่อเซลล์ fibroblast ผลต่อเอนไซม์ collagenase และประสิทธิภาพในการลดริ้วรอยผิวหนัง แต่ละโครงการได้ดำเนินการแล้วเสร็จโดยมีรายละเอียดในรายงานวิจัยแต่ละโครงการ ในภาพรวมกล่าวสรุปได้ว่า แก่นมะหาดซึ่งมีสารสำคัญคือ oxyresveratrol มีศักยภาพที่เด่นชัด เหมาะสมที่จะนำมาพัฒนาใช้ในอุตสาหกรรมเครื่องสำอางต่อไป ส่วนการพัฒนาเป็นยาต้า
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Ittmann, Michael M. Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada446482.

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Shaw, Aubie. Fibroblast TGF-beta Signaling in Breast Development and Cancer. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada534815.

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Shaw, Aubie. Fibroblast TGF-Beta Signaling in Breast Development and Cancer. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada576374.

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Ittmann, Michael M. Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada462818.

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Ittmann, Michael M. Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada476956.

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