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Journal articles on the topic 'Fibroblastic'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Plaisancié, Pascale, Charline Buisson, Edwin Fouché, et al. "Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture." PLOS ONE 17, no. 8 (2022): e0273858. http://dx.doi.org/10.1371/journal.pone.0273858.

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Continuous and rapid renewal of the colonic epithelium is crucial to resist the plethora of luminal deleterious agents. Subepithelial fibroblasts contribute to this turnover by regulating epithelial proliferation and differentiation. However, when intestinal homeostasis is disturbed, fibroblasts can acquire an activated phenotype and play a major role in the progression of intestinal pathologies. To evaluate the involvement of fibroblasts in the regulation of colonocytes under homeostatic or pathological conditions, we established resting and activated conditionally immortalized fibroblast cel

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Bouziges, F., P. Simon-Assmann, C. Leberquier, K. Haffen, and M. Kedinger. "Glycosaminoglycan expression in intestinal epithelial skin-fibroblastic cell cocultures. Fibroblastic cell-mediated effects of glucocorticoids." Journal of Cell Science 92, no. 4 (1989): 679–85. http://dx.doi.org/10.1242/jcs.92.4.679.

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The nature and distribution of newly synthesized glycosaminoglycans (GAGs) were studied in foetal rat skin fibroblasts, in rat intestinal endodermal cells and in cocultures of both cell types. The data show that fibroblasts synthesize and secrete hyaluronic acid (HA), heparan sulphate (HS) and chondroitin sulphate molecules (CS). Our data focus on HA, which is found as two different molecular forms, the smallest hydrodynamic-sized species being mostly recovered within the cell or associated with the cell surface, and the largest one secreted into the medium, whatever the cell type. Endodermal

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3

Heng, Madalene. "Phosphorylase Kinase Inhibition Therapy in Burns and Scalds." BioDiscovery 20 (February 24, 2017): e11207. https://doi.org/10.3897/biodiscovery.20.e11207.

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Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts. Myofibroblasts contain α-smooth muscle actin which has contractile properties and can lead to wound contraction and hypertrophic scarring. Phosphorylase kinase (PhK), expressed within 5 mins of injury, is among the earliest enzymes released after tissue damage. It is responsible for activation of NF-kB, which in turn activates over 200 different genes related to inflammation, fibroblas

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Kim, Hyun-Jin, Seong-Min Kim, Min-Jeong Choi та Young-Joo Jang. "Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-β1-Induced Periodontal Ligament-Fibroblastic Differentiation". Stem Cells International 2022 (16 липня 2022): 1–15. http://dx.doi.org/10.1155/2022/3273779.

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Human periodontal ligament stem cells (hPDLSCs) can be differentiated into periodontal ligament- (PDL-) fibroblastic progenitors by treatment with low concentrations of transforming growth factor beta 1 (TGF-β1). Although much is known about the profibrotic effects of TGF-β1, the molecular mechanisms mediating the activation of fibroblasts in periodontal ligament-fibroblastic differentiation are not well known. Our study was to investigate the mechanism of the fibroblastic process in the periodontal ligament differentiation of hPDLSCs through the discovery of novel markers. One of the monoclon

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Lupu, Florea, Robert Silasi-Mansat, Ravi Keshari, et al. "Persistent inflammation and fibrosis of the lung are long-term complications of sepsis in baboons (P4015)." Journal of Immunology 190, no. 1_Supplement (2013): 131.8. http://dx.doi.org/10.4049/jimmunol.190.supp.131.8.

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Abstract Sepsis-induced inflammation of the lung leads to acute respiratory distress syndrome (ARDS), which may trigger persistent fibrotic responses. We have developed a baboon model of E. coli sepsis-induced ARDS and characterized the long-term (6-24 months) effects of sepsis on the lung. By immunocytochemistry, we detected focal accumulation of neutrophils, M2 macrophages, IL17 and TGF-β positive cells, which indicates persistent inflammation in the lung, months after clinical recovery from the acute sepsis episode. Microscopical and biochemical quantification demonstrated an almost doublin

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Roy, Bibhas, Luezhen Yuan, Yaelim Lee, Aradhana Bharti, Aninda Mitra, and G. V. Shivashankar. "Fibroblast rejuvenation by mechanical reprogramming and redifferentiation." Proceedings of the National Academy of Sciences 117, no. 19 (2020): 10131–41. http://dx.doi.org/10.1073/pnas.1911497117.

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Over the course of the aging process, fibroblasts lose contractility, leading to reduced connective-tissue stiffness. A promising therapeutic avenue for functional rejuvenation of connective tissue is reprogrammed fibroblast replacement, although major hurdles still remain. Toward this, we recently demonstrated that the laterally confined growth of fibroblasts on micropatterned substrates induces stem-cell-like spheroids. In this study, we embedded these partially reprogrammed spheroids in collagen-I matrices of varying densities, mimicking different three-dimensional (3D) tissue constraints.

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Bronson, R. E., J. A. Treat, and C. N. Bertolamp. "Fibroblastic Subpopulations in Uninjured and Wounded Rabbit Oral Mucosa." Journal of Dental Research 68, no. 1 (1989): 51–58. http://dx.doi.org/10.1177/00220345890680010801.

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Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamine into GAG in cellular, pericellular, and medium fractions, with the majority of incorporated label residing in the medium. Dermatan sulfate (DS) was the predominant GAG in the medium fraction of both normal and wound fibroblast cultures; however, the two cell lines differed in th

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Cai, Zhou, Hua Guo, Jing Qian та ін. "Effects of bone morphogenetic protein 4 on TGF-β1-induced cell proliferation, apoptosis, activation and differentiation in mouse lung fibroblasts via ERK/p38 MAPK signaling pathway". PeerJ 10 (27 липня 2022): e13775. http://dx.doi.org/10.7717/peerj.13775.

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Fibroblasts, in particular myofibroblasts, are the critical effector cells in idiopathic pulmonary fibrosis (IPF), a deadly lung disease characterized by abnormal lung remodeling and the formation of “fibroblastic foci”. Aberrant activation of TGF-β1 is frequently encountered and promotes fibroblast proliferation, activation, and differentiation in pulmonary fibrosis. Hence, the inhibition of TGF-β1-induced lung fibroblast activation holds promise as a therapeutic strategy for IPF. The present study aimed to investigate the potential effect and underlying mechanisms of bone morphogenetic prote

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Douillet, Camille, Marc Nicodeme, Loïc Hermant, et al. "From local to global matrix organization by fibroblasts: a 4D laser-assisted bioprinting approach." Biofabrication 14, no. 2 (2022): 025006. http://dx.doi.org/10.1088/1758-5090/ac40ed.

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Abstract Fibroblasts and myofibroblasts play a central role in skin homeostasis through dermal organization and maintenance. Nonetheless, the dynamic interactions between (myo)fibroblasts and the extracellular matrix (ECM) remain poorly exploited in skin repair strategies. Indeed, there is still an unmet need for soft tissue models allowing to study the spatial-temporal remodeling properties of (myo)fibroblasts. In vivo, wound healing studies in animals are limited by species specificity. In vitro, most models rely on collagen gels reorganized by randomly distributed fibroblasts. But biofabric

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Cadosch, Nadine, Cristina Gil-Cruz, Christian Perez-Shibayama, and Burkhard Ludewig. "Cardiac Fibroblastic Niches in Homeostasis and Inflammation." Circulation Research 134, no. 12 (2024): 1703–17. http://dx.doi.org/10.1161/circresaha.124.323892.

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Fibroblasts are essential for building and maintaining the structural integrity of all organs. Moreover, fibroblasts can acquire an inflammatory phenotype to accommodate immune cells in specific niches and to provide migration, differentiation, and growth factors. In the heart, balancing of fibroblast activity is critical for cardiac homeostasis and optimal organ function during inflammation. Fibroblasts sustain cardiac homeostasis by generating local niche environments that support housekeeping functions and by actively engaging in intercellular cross talk. During inflammatory perturbations,

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Zorina, Alla, Vadim Zorin, Dmitry Kudlay, and Pavel Kopnin. "Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging." International Journal of Molecular Sciences 23, no. 11 (2022): 6135. http://dx.doi.org/10.3390/ijms23116135.

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Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and function. The processes developing in the skin during aging are based on fundamental molecular mechanisms associated with fibroblasts, the main cellular population of the dermis. It has been revealed that the amount of fibroblasts decreases markedly with age and their functional activity is also reduced. This inevitably leads to a decrease in the regenerative abilities of the skin and the progression of its aging. In this review we consider the mechanisms underlying these processes, mainly the changes

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OSTLERE, L. S., H. P. STEVENS, M. JARMULOWICZ, C. HIGGENS, C. BLACK, and M. H. A. RUSTIN. "Fibroblastic rheumatism." Clinical and Experimental Dermatology 19, no. 3 (1994): 268–70. http://dx.doi.org/10.1111/j.1365-2230.1994.tb01185.x.

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13

Parida, JyotiRanjan. "Fibroblastic rheumatism." Indian Journal of Rheumatology 12, no. 6 (2017): 189. http://dx.doi.org/10.4103/0973-3698.219082.

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14

du Toit, Riette, J. W. Schneider, and D. A. Whitelaw. "Fibroblastic Rheumatism." JCR: Journal of Clinical Rheumatology 12, no. 4 (2006): 201–3. http://dx.doi.org/10.1097/01.rhu.0000231383.50323.b5.

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Marconi, I. M. L., M. C. Rivitti-Machado, M. N. Sotto, and M. M. S. Nico. "Fibroblastic rheumatism." Clinical and Experimental Dermatology 34, no. 1 (2009): 29–32. http://dx.doi.org/10.1111/j.1365-2230.2008.02748.x.

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16

Vignon-Pennamen, Marie-D., Bertrand Naveau, Christine Foldes, et al. "Fibroblastic rheumatism." Journal of the American Academy of Dermatology 14, no. 6 (1986): 1086–88. http://dx.doi.org/10.1016/s0190-9622(86)80186-4.

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du Bois, Roland M. "Fibroblastic Foci." Chest 130, no. 1 (2006): 3–5. http://dx.doi.org/10.1378/chest.130.1.3.

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18

Kanzler, Matthew H. "Fibroblastic Rheumatism." Archives of Dermatology 131, no. 6 (1995): 710. http://dx.doi.org/10.1001/archderm.1995.01690180086016.

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Kanzler, M. H. "Fibroblastic rheumatism." Archives of Dermatology 131, no. 6 (1995): 710–12. http://dx.doi.org/10.1001/archderm.131.6.710.

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20

Sanford-Crane, Hannah, Jaime Abrego, and Mara H. Sherman. "Fibroblasts as Modulators of Local and Systemic Cancer Metabolism." Cancers 11, no. 5 (2019): 619. http://dx.doi.org/10.3390/cancers11050619.

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Fibroblast activation is an accompanying feature of solid tumor progression, resembling a conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous and plastic population with increasingly appreciated roles in tumor growth, metastatic capacity, and response to therapy. Classical features of fibroblasts in a wound-healing response, including profound extracellular matrix production and cytokine release, are recapitulated in cancer. Emerging evidence suggests that fibroblastic cells in the microenvironments of solid tumors also critically modulate ce

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YiXin, Luo, Niu ShaoNa, Mai LiFang, Liu XingZhou, and Yang Chuan. "Comparison of different concentrations of chlorhexidine-iodophor composite solution on human skin fibroblasts." Journal of Wound Care 33, Sup2a (2024): xxxii—xl. http://dx.doi.org/10.12968/jowc.2024.33.sup2a.xxxii.

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Objective: Chlorhexidine-iodophor (CHX-IP) composite solution is a polymer of chlorhexidine and iodophor produced with new technology, for use in diabetic foot infection. However, the effect of CHX-IP on the growth activity of fibroblasts remains unknown, thus the effects of different concentrations of CHX-IP composite solution on the viability and micromorphology of human skin fibroblasts were studied in vitro cell culture in this study. Method: A cell viability assay was applied to calculate cell viability and an inverted fluorescence microscope was used to observe cell morphology over five

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22

Magomedov, Sadrudin, Yurii Polyachenko, Оlexandr Kostrub, Roman Blonskyi, and Ivan Zasadnyuk. "THE INFLUENCE OF THE CULTURE OF FIBROBLASTIC CELL ELEMENTS ON THE INDICATORS OF THE METABOLISM OF CONNECTIVE TISSUE IN EXPERIMENTAL ANIMALS." ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, no. 3 (October 8, 2024): 65–69. http://dx.doi.org/10.15674/0030-59872024365-69.

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The number of patients with degenerative tendon disease affects millions of people both among athletes and the general population, causing significant socio-economic consequences. Despite the availability of various methods of conservative and surgical treatment, more than a third of patients experience constant pain. Objective. To study the indicators of the metabolism of connective tissue in animals with a model of degenerative damage to tendons against the background of the introduction of a culture of fibroblastic cell elements. Methods. Therefore, the development of methods for restoring

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Da Silva Teixeira, Maria Fatima, Véronique Lambert, Laila Mselli-Lakahl, Abdelkamel Chettab, Yahia Chebloune, and Jean-François Mornex. "Immortalization of caprine fibroblasts permissive for replication of small ruminant lentiviruses." American Journal of Veterinary Research 58, no. 6 (1997): 579–84. http://dx.doi.org/10.2460/ajvr.1997.58.06.579.

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Abstract Objective To establish immortalized caprine fibroblastic cell lines permissive for replication of small ruminant lentiviruses. Animals Carpal synovial membrane explants collected aseptically from a surgically delivered fetus of a lentivirus-seronegative goat. Procedure Immortalization of goat embryonic fibroblasts was performed by DNA transfection with plasmids coding for simian virus 40 large T antigen. The generated cell lines were phenotypically characterized. Cytogenetics, growth pattern, and sensitivity to viral infection were studied. Results 3 cell lines, designated TIGEF, mMTS

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Ishizaki, Masamichi, Kyoko Wakamatsu, Takakuni Matsunami, Nobuaki Yamanaka, Toshikazu Saiga, and Winston W. Y. Kao. "Appearance of myofibroblast during the healing of experimental corneal wound." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 386–87. http://dx.doi.org/10.1017/s0424820100147764.

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It is well known that corneal stroma cells (keratocytes) can transform to fibroblasts during the corneal wound healing. We have studied the expression of α-smooth muscle actin, vimentin and desmin in fibroblastic cells of the alkali-burneo and lacerated corneas in the rabbits by means of immunohistochemistry and electron microscopy.Methods. Rabbits were anesthetized, and central corneal alkali-burn and laceration were produced. The injured corneas healed for 1 day to 45 days, and 18 days embryonic rabbit corneas were immunostained with monoclonal antibodies against α-smooth muscle actin, vimen

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Ruggeri, A., L. Montebugnoli, A. Matteucci та ін. "Cyclosporin A Specifically Affects Nuclear PLCβ1 in Immunodepressed Heart Transplant Patients with Gingival Overgrowth". Journal of Dental Research 84, № 8 (2005): 747–51. http://dx.doi.org/10.1177/154405910508400812.

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One of the most commonly observed adverse effects of cyclosporin A (CsA) is the development of gingival overgrowth (GO). Fibroblasts are involved in GO, but the question why only a percentage of patients undergoing CsA treatment shows this side-effect remains unanswered. In a previous study, CsA has been demonstrated to induce over-expression of phospholipase C (PLC) β1 in fibroblasts of patients with clinical GO, in cells from both enlarged and clinically healthy gingival sites. In this work, we assessed the expression of PLCβ isoforms to investigate whether the exaggerated fibroblast respons

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Havemose-Poulsen, Anne, and Palle Holmstrup. "Factors Affecting IL-1-Mediated Collagen Metabolism By Fibroblasts and the Pathogenesis of Periodontal Disease: A Review of the Literature." Critical Reviews in Oral Biology & Medicine 8, no. 2 (1997): 217–36. http://dx.doi.org/10.1177/10454411970080020801.

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Fibroblasts have been studied extensively for their contribution to connective tissue destruction in diseases where the metabolism of extracellular matrix components plays an essential part in their pathogenesis. A considerable dissolution, especially of collagen fibrils, is a well-known characteristic of the periodontal ligament and the gingival connective tissue in microbial-induced periodontal disease. Fibroblasts, responsible for the assembly of the extracellular matrix, are capable of responding directly to oral microbial challenges or indirectly, following activation of the host immune r

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Jara, Paul, Jazmin Calyeca, Yair Romero, et al. "Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 6 (2015): L511—L522. http://dx.doi.org/10.1152/ajplung.00043.2014.

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Idiopathic pulmonary fibrosis (IPF) is a progressive and usually lethal interstitial lung disease of unknown etiology characterized by aberrant activation of epithelial cells that induce the migration, proliferation and activation of fibroblasts. The resulting distinctive fibroblastic/myofibroblastic foci are responsible for the excessive extracellular matrix (ECM) production and abnormal lung remodeling. We have recently found that matrix metalloproteinase 19 (MMP-19)-deficient ( Mmp19−/−) mice develop an exaggerated bleomycin-induced lung fibrosis, but the mechanisms are unclear. In this stu

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Zhou, Zhi Hua, Yong Yi Gao, Qing Feng Yi, Qing Quan Liu, and Li Hua Liu. "Study on the Cytotoxicity In Vitro of Composite Materials Based on Poly(L-Lactide-Co-Glycolide) and Bioactive Glass." Materials Science Forum 685 (June 2011): 384–89. http://dx.doi.org/10.4028/www.scientific.net/msf.685.384.

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The effect of poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) on cell attachment, proliferation and differentiation of L929 fibroblastic cells was investigated. The results ofin-vitrocytotoxicity test indicated that the cells cultured in extract of PLGA/BG and on the surface of composite showed normal growth and proliferation. The cell proliferation and alkaline phosphatase (ALP) activity of fibroblast were significantly improved after 3 and 7 days of culture on PLGA/BG films in comparison with PLGA films. It can be concluded that the addition of bioactive glass into PLGA stimulates the

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Nehls, Daniel G., Volker K. H. Sonntag, Alan R. Murphy, Peter C. Johnson, and John D. Waggener. "Fibroblastic tumor of the abducens nerve." Journal of Neurosurgery 62, no. 2 (1985): 296–99. http://dx.doi.org/10.3171/jns.1985.62.2.0296.

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✓ Tumors of the cranial nerves are uncommon, and are usually schwannomas or neurofibromas. The authors describe a case of a fibroblastic tumor involving the sixth cranial nerve. Based upon electron microscopy and immunohistochemistry, the tumor was not of nerve-sheath origin, but was comprised of fibroblasts. Clinical, radiographic, and pathological material are presented, and the literature is discussed. This represents the third case report of a tumor of the abducens nerve, and the first report of a fibroma of a cranial or peripheral nerve.

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Vida, Vladimiro L., Arben Dedja, Elisabetta Faggin, et al. "The effects of basic fibroblast growth factor in an animal model of acute mechanically induced right ventricular hypertrophy." Cardiology in the Young 22, no. 4 (2012): 436–42. http://dx.doi.org/10.1017/s1047951111002034.

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AbstractObjectiveTo evaluate the effect of a continuous infusion of basic fibroblast growth factor on the adaptive potential of the right ventricular myocardium after 30 days of mechanically induced overload in rats.Materials and methodsWe banded the pulmonary trunk, so as to increase the systolic workload of the right ventricle, in six Lewis/HanHsd rats at the age of 11 weeks, using six adult rats as controls. The six adult rats were also banded and received an additional continuous infusion of basic fibroblastic growth factor, using six rats with a continuous infusion of basic fibroblastic g

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Laskin, William B., John F. Fetsch, and Markku Miettinen. "Myxoinflammatory Fibroblastic Sarcoma." American Journal of Surgical Pathology 38, no. 1 (2014): 1–12. http://dx.doi.org/10.1097/pas.0b013e31829f3d85.

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Kumar, Rajendra, Robert A. Lefkowitz, and Afranio Dos Reis Teixeira Neto. "Myxoinflammatory Fibroblastic Sarcoma." Journal of Computer Assisted Tomography 41, no. 1 (2017): 104–15. http://dx.doi.org/10.1097/rct.0000000000000490.

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García-García, Elena, Yolanda Rodríguez-Gil, Ana Suárez-Gauthier, Francisco José Martínez-Tello, Fernando López-Ríos, and Claudio Ballestín. "Myxoinflammatory Fibroblastic Sarcoma." Acta Cytologica 51, no. 2 (2007): 231–34. http://dx.doi.org/10.1159/000325724.

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Kobayashi, Eisuke, Akira Kawai, Makoto Endo, et al. "Myxoinflammatory fibroblastic sarcoma." Journal of Orthopaedic Science 13, no. 6 (2008): 566–71. http://dx.doi.org/10.1007/s00776-008-1274-y.

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Abade dos Santos, Fábio A., C. L. Carvalho, Isabel Almeida, et al. "Simple Method for Establishing Primary Leporidae Skin Fibroblast Cultures." Cells 10, no. 8 (2021): 2100. http://dx.doi.org/10.3390/cells10082100.

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Commercial hare and rabbit immortalized cell lines are extremely limited regarding the many species within the lagomorpha order. To overcome this limitation, researchers and technicians must establish primary cell cultures derived from biopsies or embryos. Among all cell types, fibroblasts are plastic and resilient cells, highly convenient for clinical and fundamental research but also for diagnosis, particularly for viral isolation. Here, we describe a fast and cheap method to produce primary fibroblast cell cultures from leporid species, using dispase II, a protease that allows dermal–epider

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Rook, M. B., A. C. van Ginneken, B. de Jonge, A. el Aoumari, D. Gros, and H. J. Jongsma. "Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs." American Journal of Physiology-Cell Physiology 263, no. 5 (1992): C959—C977. http://dx.doi.org/10.1152/ajpcell.1992.263.5.c959.

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Cultures of neonatal rat heart cells contain predominantly myocytes and fibroblastic cells. Most abundant are groups of synchronously contracting myocytes, which are electrically well coupled through large gap junctions. Cardiac fibroblasts may be electrically coupled to each other and to adjacent myocytes, be it with low intercellular conductances. Nevertheless, synchronously beating myocytes interconnected via a fibroblast were present, demonstrating that nonexcitable cardiac cells are capable of passive impulse conduction. In fibroblast pairs as well as in myocyte-fibroblast cell pairs, no

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Huber, Aaron R., and James F. Shikle. "Benign Fibroblastic Polyps of the Colon." Archives of Pathology & Laboratory Medicine 133, no. 11 (2009): 1872–76. http://dx.doi.org/10.5858/133.11.1872.

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Abstract Benign fibroblastic polyps of the colon are a recently described entity among mucosal polyps found in the colorectum. These polyps are typically discovered on routine screening colonoscopy within the distal colon. Benign fibroblastic polyps occur most commonly in adult women in the sixth decade of life. Histologically, benign fibroblastic polyps are bland spindle cell lesions that fill the lamina propria and displace the surrounding crypts. The spindle cell proliferation lacks atypia and significant mitotic activity. Hyperplastic changes are frequently present both in the adjacent epi

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Strutz, F., H. Okada, C. W. Lo, et al. "Identification and characterization of a fibroblast marker: FSP1." Journal of Cell Biology 130, no. 2 (1995): 393–405. http://dx.doi.org/10.1083/jcb.130.2.393.

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We performed subtractive and differential hybridization for transcript comparison between murine fibroblasts and isogenic epithelium, and observed only a few novel intracellular genes which were relatively specific for fibroblasts. One such gene encodes a filament-associated, calcium-binding protein, fibroblast-specific protein 1 (FSP1). The promoter/enhancer region driving this gene is active in fibroblasts but not in epithelium, mesangial cells or embryonic endoderm. During development, FSP1 is first detected by in situ hybridization after day 8.5 as a postgastrulation event, and is associat

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Lebel, Mégane, Dominic O. Cliche, Martine Charbonneau, et al. "Invadosome Formation by Lung Fibroblasts in Idiopathic Pulmonary Fibrosis." International Journal of Molecular Sciences 24, no. 1 (2022): 499. http://dx.doi.org/10.3390/ijms24010499.

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Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal fibroblast accumulation in the lung leading to extracellular matrix deposition and remodeling that compromise lung function. However, the mechanisms of interstitial invasion and remodeling by lung fibroblasts remain poorly understood. The invadosomes, initially described in cancer cells, consist of actin-based adhesive structures that coordinate with numerous other proteins to form a membrane protrusion capable of degrading the extracellular matrix to promote their invasive phenotype. In this regard, we hypothesized that invadoso

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Shibasaki, Y., T. Asano, J. L. Lin, et al. "Two glucose transporter isoforms are sorted differentially and are expressed in distinct cellular compartments." Biochemical Journal 281, no. 3 (1992): 829–34. http://dx.doi.org/10.1042/bj2810829.

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Rat GLUT4 (adipocyte/muscle-type glucose transporter) was expressed in two fibroblastic cell lines, Chinese hamster ovary (CHO) cells and 3T3-L1 fibroblasts, under the control of the methallothionein I promoter. Although immunoblotting with a GLUT4-specific anti-peptide antibody demonstrated that the amount of GLUT4 expressed was comparable with that in 3T3-L1 adipocytes and rat adipose tissues, no increase in 2-deoxy-D-glucose uptake was observed in the basal state in fibroblasts. Immunocytochemical studies showed that the expressed GLUT4 appeared to be localized in a specific region in the c

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Eyden, Brian. "Fibroblast Phenotype Plasticity: Relevance for Understanding Heterogeneity in “Fibroblastic” Tumors." Ultrastructural Pathology 28, no. 5-6 (2004): 307–19. http://dx.doi.org/10.1080/019131290882204.

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Cheng, Yansiwei, Yuhao Zhou, Wenjun Lv, Qing Luo та Guanbin Song. "Simulated Microgravity Inhibits Rodent Dermal Fibroblastic Differentiation of Mesenchymal Stem Cells by Suppressing ERK/β-Catenin Signaling Pathway". International Journal of Molecular Sciences 22, № 19 (2021): 10702. http://dx.doi.org/10.3390/ijms221910702.

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Studies have shown that bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into dermal fibroblasts to participate in skin-repairing. However, at present, little is known about how microgravity affects dermal fibroblastic differentiation of BMSCs in space. The aim of this study was to investigate the effect of simulated microgravity (SMG) on the differentiation of BMSCs into dermal fibroblasts and the related molecular mechanism. Here, using a 2D-clinostat device to simulate microgravity, we found that SMG inhibited the differentiation and suppressed the Wnt/β-catenin signalin

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Mariani, Thomas J., Stephanie Sandefur, Jill D. Roby та Richard A. Pierce. "Collagenase-3 Induction in Rat Lung Fibroblasts Requires the Combined Effects of Tumor Necrosis Factor-α and 12-Lipoxygenase Metabolites: A Model of Macrophage-induced, Fibroblast-driven Extracellular Matrix Remodeling during Inflammatory Lung Injury". Molecular Biology of the Cell 9, № 6 (1998): 1411–24. http://dx.doi.org/10.1091/mbc.9.6.1411.

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The mechanisms responsible for the induction of matrix-degrading proteases during lung injury are ill defined. Macrophage-derived mediators are believed to play a role in regulating synthesis and turnover of extracellular matrix at sites of inflammation. We find a localized increase in the expression of the rat interstitial collagenase (MMP-13; collagenase-3) gene from fibroblastic cells directly adjacent to macrophages within silicotic rat lung granulomas. Conditioned medium from macrophages isolated from silicotic rat lungs was found to induce rat lung fibroblast interstitial collagenase gen

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Liu, Fei, David Lagares, Kyoung Moo Choi, et al. "Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis." American Journal of Physiology-Lung Cellular and Molecular Physiology 308, no. 4 (2015): L344—L357. http://dx.doi.org/10.1152/ajplung.00300.2014.

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Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis. YAP and TAZ are prominently expressed in fibrotic but not health

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Gabrielli, A., M. G. Danieli, M. Candela, A. M. Ricciatti, C. Nitti, and G. Danieli. "The Potential Role of Cytokines in the Pathogenesis of Systemic Sclerosis (Scleroderma)." International Journal of Immunopathology and Pharmacology 5, no. 2 (1992): 135–40. http://dx.doi.org/10.1177/039463209200500209.

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Systemic sclerosis (scleroderma) is characterized by excessive fibroblastic activity taking place through mechanisms largely unknown. It has been speculated that soluble factors, collectively categorized as lymphokines or monokines, and released by inflammatory or other differentiated cells, may modulate fibroblast multiple functions including migration, chemotaxis and protein synthesis. Vascular endothelium itself, which is deeply injured in systemic sclerosis, is acting as a target for the action of cytokines and is an important producer of polypeptide mediators that contribute to the inflam

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Sylvia, Charles J., Molly A. Wagel, Kamna Giare-Patel, Taylor A. Spangler, Eugene M. Breznock, and Nisha Gupta. "Chlorhexidine-coated peripherally inserted central catheters reduce fibroblastic sleeve formation in an in vivo ovine model." Journal of Vascular Access 19, no. 6 (2018): 644–50. http://dx.doi.org/10.1177/1129729818769033.

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Purpose: This study compared an antimicrobial and anti-thrombogenic peripherally inserted central catheter treated with a chlorhexidine-based technology, a peripherally inserted central catheter with bulk distributed fluoro-oligomers, and a poly 2-methoxyethyl acrylate–based peripherally inserted central catheter to an untreated peripherally inserted central catheter (control) in an ovine model at 14 and 30 days post-implant. Methods: One of four types of peripherally inserted central catheters was surgically implanted into the left jugular vein of each of 18 sheep for 14 or 30 days. Blood ana

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Fagerstedt, Klaus W., Tarja Salonen, Fang Zhao, Soili Kytölä, Tom Böhling, and Leif C. Andersson. "Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma." Tumor Biology 40, no. 5 (2018): 101042831877793. http://dx.doi.org/10.1177/1010428318777936.

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Myxoinflammatory fibroblastic sarcoma is a soft-tissue neoplasm most frequently found in the distal extremities of middle-aged adults. Most myxoinflammatory fibroblastic sarcoma are low-grade tumors with propensity for local recurrence after incomplete removal. We report a myxoinflammatory fibroblastic sarcoma which developed in the foot of a 41-year-old male and showed an exceptionally aggressive course with metastatic spread and fatal outcome within 16 months. We managed to establish a spontaneously transformed continuous cell line, called JU-PI, from a metastatic lesion. The JU-PI cells hav

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Rodrigues, Annelissa Zorzeto, Paulo Tambasco de Oliveira, Arthur Belém Novaes Jr., Luciana Prado Maia, Sérgio Luís Scombatti de Souza, and Daniela Bazan Palioto. "Evaluation of in vitro human gingival fibroblast seeding on acellular dermal matrix." Brazilian Dental Journal 21, no. 3 (2010): 179–89. http://dx.doi.org/10.1590/s0103-64402010000300001.

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The acellular dermal matrix (ADM) was introduced in periodontology as a substitute for the autogenous grafts, which became restricted because of the limited source of donor's tissue. The aim of this study was to investigate, in vitro, the distribution, proliferation and viability of human gingival fibroblasts seeded onto ADM. ADM was seeded with human gingival fibroblasts for up to 21 days. The following parameters were evaluated: cell distribution, proliferation and viability. Results revealed that, at day 7, fibroblasts were adherent and spread on ADM surface, and were unevenly distributed,

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Matveyenkava, T. D., I. V. Nazarenko, А. М. Yurkovskiy, and M. N. Starodubtseva. "Radiation-induced changes in the properties and functions of fibroblasts." Health and Ecology Issues 20, no. 4 (2024): 7–17. http://dx.doi.org/10.51523/2708-6011.2023-20-4-01.

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This review is devoted to the analysis of the literature containing experimental and clinical data on radiation-induced changes in connective tissue and its cellular component to create an overall picture of the leading mechanisms of radiation fibrosis development.The review analyzed publications for the period 1995-2022, presented in three academic databases: Scopus, PubMed and Web of Science. In the search process, various combinations of logical operators (or, and, not) were used to combine search keywords (ionizing radiation, connective tissue, fibroblasts) to find relevant studies in acad

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Fontenay-Roupie, M., E. Dupuy, E. Berrou, G. Tobelem, and M. Bryckaert. "Increased proliferation of bone marrow-derived fibroblasts in primitive hypertrophic osteoarthropathy with severe myelofibrosis." Blood 85, no. 11 (1995): 3229–38. http://dx.doi.org/10.1182/blood.v85.11.3229.bloodjournal85113229.

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Pachydermoperiostosis or primary hypertrophic osteoarthropathy (HOA) is a rare congenital growth disorder of connective tissue. We report a case of severe myelofibrosis in a patient with HOA. When cultured in vitro, patient bone marrow-derived fibroblasts displayed a high proliferative potential with a shortened doubling time (24 hours v 36 to 48 hours for normal fibroblasts). The role of platelet-derived growth factor (PDGF), previously implicated in the pathogenesis of secondary acquired myelofibrosis, was studied. HOA fibroblasts expressed an increased number of PDGF-BB binding sites (300,0

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