Academic literature on the topic 'Fibroina'

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Journal articles on the topic "Fibroina"

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Bittencourt, Paulo Rodrigo Stivial, Luciano Moura de Souza, Natália Zanotelli, and Fernando Reinoldo Scremin. "Incorporação de fibroina de Bombyx mori e nanotubos em sistemas de poliamida 6." Acta Brasiliensis 2, no. 3 (September 12, 2018): 106. http://dx.doi.org/10.22571/2526-4338118.

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A fibroina da seda é um biopolímero natural proveniente de Bombyx mori L. (bicho da seda) que possui excelente estabilidade térmica e resistência mecânica. Parte deste biopolimero é rejeitada no processo industrial devido a escolha de casulos viáveis para a produção de seda de qualidade. O objetivo dessa pesquisa foi reaproveitar o biopolímero natural proveniente de B. mori para produzir sistemas, processados por casting, de misturas de poliamida 6 com nanotubo de carbono funcionalizado com carboxila e a fibroina. O filme polimérico foi obtido por casting, utilizando ácido fórmico como solvente. As propriedades físico-químicas foram analisadas por Espectroscopia no Infravermelho, análise termogravimétrica e ensaios de tração mecânica. Os resultados das análises reportaram o aumento na estabilidade térmica e mecãnica dos filmes com a presença de fibroina e MWNT nos compósitos de poliamida 6, tendo atingido um módulo de elasticidade de 4,0 GPa com 0,025% em massa de nanotubo no compósito. Assim, a incorporação da fibroína, extraída de casulos considerados defeituosos, em compósito com poliamida 6 e nanotubo de carbono funcionalizado com carboxila melhorou a estabilidade mecânica nestes sistemas quando comparado a poliamida 6 pura, formando um sistema com potencial uso como material de engenharia.
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Caballero Méndez, Lyda, and Duverney Gaviria Arias. "Desarrollo y caracterización de películas de fibroina de seda para reparación condral." Revista Colombiana de Biotecnología 21, no. 1 (January 1, 2019): 71–81. http://dx.doi.org/10.15446/rev.colomb.biote.v21n1.73137.

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La fibroína de seda es una proteína que ha demostrado ser un biomaterial con gran potencial en medicina regenerativa, por suscaracterísticas de biocompatibilidad y su amplia posibilidad de modificación estructural permite ser usada como andamio favore-ciendo procesos de crecimiento, diferenciación celular y la regeneración del tejido afectado.En este estudio se utilizaron capullos de gusano de seda Bombyx moriL., para la fabricación de películas de fibroína, los capullos fueron desgomados utilizando Na2CO30,02M, la fibroína obtenida se disolvió con LiBr 9,3M, el cual fue eliminado mediante diáli-sis y finalmente la solución de fibroína fue concentrada mediante contradiálisis. La fibroína fue servida en cajas de poliestireno, se-cadas a 90°C/24 horas y esterilizadas con etanol al 70%. Células madre mesenquimales fueron sembradas sobre estas películas de fibroína e inducidas a diferenciación utilizando un medio condrogénico especifico. La diferenciación fue evaluada por triplicadoa los 14 y 21 días mediante extracción de ARN total, síntesis de ADN copia y amplificación por PCR de un grupo de genes específi-cos de cartílago empleando cebadores específicos.Se fabricaron películas de fibroína estables y resistentes que permitieron el crecimiento y la multiplicación celular, así como la dife-renciación condrogénica evidenciada por la expresión de genes condrogenicos, no se afectó la viabilidad ni el recuento celular, las células interactuaron con el andamio evidenciado por el área de tapizado formado sobre la superficie de la película de fibroína.Finalmente se concluye que la fibroína de seda es un biomaterial que puede servir de andamio potencial para la regeneración de lesiones articulares.
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Nadir qızı Kərimova, Sevinc. "Uterine fibroids." NATURE AND SCIENCE 07, no. 02 (April 23, 2021): 22–24. http://dx.doi.org/10.36719/2707-1146/07/22-24.

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Fibroids (especially large ones) deform the uterine cavity, compressing the fallopian tubes, making it difficult for sperm to move. In addition, in women with fibroids, in many cases, the hormonal background is disturbed, as a result of which a woman may not ovulate. The factors we have listed can lead to infertility in women. Doctors recommend women with fibroids to treat fibroids during the planning stage of pregnancy or, in some cases, to remove fibroids before pregnancy. A woman can plan a pregnancy 6 months after the fibroid is removed. Key words: fibroma, uterus, pregnancy
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Kovarik Antonović, Ivana. "Novim putovima svile prema održivoj alternativi za umjetnim kožnim materijalima." Koža & obuća 69, no. 3-4 (December 31, 2021): 16–18. http://dx.doi.org/10.34187/ko.69.3-4.4.

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Interes za ekološki prihvatljivijim modnim proizvodima znatno se povećao u zadnjih nekoliko godina kao posljedica ozbiljnog narušavanja ekološke ravnoteže uslijed ekološki nepovoljnih proizvodnih procesa. Znanstvenici Sveučilišta Tufts došli su do inovativnih rješenja u proizvodnji umjetne kože. Istraživanja su usmjerili prema biomaterijalu duge povijesti – svili. Proces izrade materijala nalik koži od svilenih vlakana uključuje razgradnju fibroina, temeljnog gradbenog polimera svile, na pojedinačne proteinske komponente u vodenoj otopini, dodatak drugih biopolimera i prirodnih aditiva te računalnu izradu (tehnologija 3D ispisa), koja omogućuje programiranje slojeva i nepravilne geometrijske uzorke. Nastali materijali pokazuju snažne, meke, savitljive, izdržljive i biorazgradive značajke, usporedive s tradicionalnim materijalima za izradu umjetne kože.
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Mijailovic, M. Z., and S. M. Lukic. "Intra-arterial embolisation of uterine fibroma." Acta chirurgica Iugoslavica 56, no. 4 (2009): 209–13. http://dx.doi.org/10.2298/aci0904209m.

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Uterine fibroid are benign tumors that consist most of the tumor occurrences in pelvic cavity of women. Possible courses of treatment include: medicament treatment, surgical and new intra-arterial embolisation method. The aim of the paper is to present achieved results in intra-arterial embolisation treatment of Uterine fibroid. Material and methods: A prospective study was performed in the period from October 2007 until October 2008. It included 36 women with symptomatic uterine fibroid. They were treated by intra-arterial embolisation. All patients had control MRI examinations after treatment. Embolisation was performed by 'cross-over' technique, using bilateral punction of femoral arteries, a selective catheterization a. uterine, and application of 750-900m Bead Blocks. Results: Average age of patients was 38.5 years. The most of fibroids had intramural localization (39%). solitary fibroids were seen in 56% of patients, multiple in 44%. Gynecological hemorrhage was the leading symptom with 34 patients (94%). One year after receiving intra-arterial embolisation treatment, fibroid regression of 50% was registered in all patients. There were no serious complications noted in our study, with the exception of postembolisation syndrome which occurred in 11 (30%) patients in a relatively mild form Conclusion: Intra-arterial embolisation of uterine fibroma is a method that in large percent of patients removes symptoms of uterine fibroma presence, prevents its growth, and safely helps women enter menopause when activity of hormone dependant tumor ceases.
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Salehi, Mohammadgharib, Nasrin Jalilian, Ayoub Salehi, and Mojgan Ayazi. "Clinical Efficacy and Complications of Uterine Artery Embolization in Symptomatic Uterine Fibroids." Global Journal of Health Science 8, no. 7 (December 18, 2015): 245. http://dx.doi.org/10.5539/gjhs.v8n7p245.

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<p>We decided to evaluate the efficacy and complications of uterine artery embolization (UAE) in patients with symptomatic uterine fibroids. Sixty-five premenopausal patients, without considering the fibroids size and its location, were treated by bilateral UAE. At baseline and after 3, 6, and 12 months MRI was obtained to determine the uterine length and fibroid diameter. In addition, symptoms of the patients were documented at these follow-up schedules. UAE was successful in 62 (95.4%) cases. Complete infarction rate of the fibroid was 83.1%. After 12 months, the uterine length showed a decrease of 55.7% (mean of 9.4 cm) and the diameter of the dominant fibroid revealed a decrease of 52.1% (mean of 3.4 cm). Menorrhagia improved in 45 cases (91.8%), abdominal mass in 24 cases (82.28%), urinary symptoms in 17 cases (85%), pelvic pain in 21 cases (84%), and dysmenorrhea in 25 cases (80.6%). At final follow-up performed after one year, complete infarction of the fibroma was demonstrated in 49 patients (83.1%). Two cases achieved successful pregnancy in the one year follow-up period. Five patients developed post-embolization syndrome which necessitated admission to the hospital. Twenty-two patients presented and complained of pain for which outpatient pain management was done. UAE was a successful treatment for uterine fibroids that preserved the uterus, had minimal complications, and required short hospitalization and recovery.</p>
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Jiang, Yu Chun, and Yuan Song Zhang. "Study on the Effect of Sericin Content on Solubility of Silk Fibroin and the Properties of Silk Fibroin Membranes." Applied Mechanics and Materials 319 (May 2013): 165–68. http://dx.doi.org/10.4028/www.scientific.net/amm.319.165.

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In this paper silkworm cocoon was dissolved at different time by degumming agents of NaHCO3 to obtain silk fibroins with different content of sericin. Then the silk fibroins was dissolved to get the silk fibroin membranes. The results indicated that the content of sericin had certain effect on silk solubility. As the content of sericin reduced, the dissolution speed was faster and the silk solubility was greater. The properties of the silk fibroin membranes with some sericin were much better than those degummed completely.
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Mailli, Leto, Eric Y. Auyoung, Salvatore A. Angileri, Seyed Ameli-Renani, Lakshmi Ratnam, Raj Das, Joo-Young Chun, Sourav Das, Isaac Manyonda, and Anna-Maria Belli. "Predicting the Fibroid-Migratory Impact of UAE: Role of Pre-embolization MRI Characteristics." CardioVascular and Interventional Radiology 43, no. 3 (October 24, 2019): 453–58. http://dx.doi.org/10.1007/s00270-019-02348-w.

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Abstract Aim To investigate potential factors on MR imaging that could be used to predict migration of uterine fibroids post-UAE. Methods and Materials We retrospectively reviewed patients referred for UAE having pre-procedural and 6 months post-procedural MRI, at a tertiary centre, over a 1-year period. Pre- and post-UAE images were reviewed in 64 women by two radiologists to identify the sub-type, dimensions, and infarction rate of each dominant fibroid. The shortest distance between the fibroid and the endometrial wall was measured to determine intramural fibroid movement. Paired sample T tests and two-sample T tests were used to compare between pre- and post-embolization variations and between migrated and non-migrated intramural fibroids, respectively. After preliminary results suggested potential predictors of intramural fibroids migration, we tested our findings against the non-dominant intramural fibroids in the same patients. Results Review of images revealed 35 dominant intramural fibroids, of which eight migrated to become submucosal fibroids, while five were either partially or completely expelled. These 13 migrated fibroids had a shorter pre-procedural minimum endometrial distance (range 1–2.4 mm) and greater maximum fibroid diameter (range 5.1–18.1 cm), when compared to non-migrating fibroids. On image reassessment, the migrated non-dominant intramural fibroids had a minimum endometrial distance and maximum fibroid diameter within the same range. Conclusion Intramural fibroids with a minimum endometrial distance less than 2.4 mm and a maximum fibroid diameter greater than 5.1 cm have a high likelihood of migrating towards the endometrial cavity after UAE.
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Knudsen, Nina Isabelle, Klaus-D. Wernecke, Heribert Kentenich, and Matthias David. "Comparison of Clinical Symptoms of Assumed vs. Actual Uterine Fibroids – Symptoms Described by Patients and Ultrasound Findings." Geburtshilfe und Frauenheilkunde 80, no. 03 (October 30, 2019): 316–23. http://dx.doi.org/10.1055/a-0991-0105.

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Abstract Purpose How many women assume that they have fibroids but are found not to have fibroids on ultrasound examination? How severe are the physical symptoms reported by these women compared to the symptoms reported by women with actual uterine fibroids? Are the symptoms more severe if the patient believes that she has at least one relatively large (dominant) fibroid or more than 3 fibroids? Material and Methods A total of 1548 patients completed an anonymous questionnaire in which they were asked about the number of their fibroids, dysmenorrhea and premenstrual symptoms, dyspareunia and bleeding disorders (using a numerical analog scale between 0 – 10). The questionnaire was administered in a hospital-based fibroid clinic. The information provided by the patients was then compared with transvaginal or abdominal ultrasound findings. The symptoms reported by women with and without fibroid(s) were compared. Results 1045 out of 1548 patients fulfilled the studyʼs inclusion criteria. Contrary to the information they provided, no fibroid(s) were detected in 6% (62 of 1045 patients) of patients on ultrasound examination. Of these women, 87% had dysmenorrhea, 79% had premenstrual pain and 57% reported dyspareunia. The severity of the symptoms was found not to be associated with the assumed size or number of fibroid(s). There was no significant difference in the pain reported by women without and by women with fibroids. Reporting a feeling of strong pressure on the bladder (OR: 1.18) or abdomen (OR: 1.12) or constipation (OR: 1.16) increased the likelihood of detecting a fibroid on ultrasound investigation. Conclusions The presence of manifest symptoms (dysmenorrhea, dyspareunia, premenstrual pain, bleeding disorders) does not allow conclusions to be made about the number or size of fibroids or about which therapy is indicated. Even an erroneous assumption about the presence of fibroids may result in patients experiencing symptoms.
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Yoon, Sang-Wook, Chan Lee, Kyoung Ah Kim, and Sang Heum Kim. "Contrast-Enhanced Dynamic MR Imaging of Uterine Fibroids as a Potential Predictor of Patient Eligibility for MR Guided Focused Ultrasound (MRgFUS) Treatment for Symptomatic Uterine Fibroids." Obstetrics and Gynecology International 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/834275.

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Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a non-invasive treatment approach for symptomatic uterine fibroids. One imaging characteristic considered in selecting patients who may benefit from MRgFUS of their uterine fibroids is the signal intensity of the fibroid compared with surrounding myometrium on T2-weighted MR images. Previous reports suggest that hyper-intense fibroids are less amenable to MRgFUS compared with iso- or hypo-intense fibroids. In this case study, we utilized contrast-enhanced dynamic MR imaging to further characterize the vascularity of a hyper-intense fibroid. Based on the results of dynamic T1-weighted contrast-enhanced images, we assumed that the hyper-intense appearance resulted from high fluid content rather than high vascularity and predicted that the fibroid would respond to MRgFUS. The patient underwent the MRgFUS without complication and reported significant decrease in fibroid symptoms at 3 and 12 months post-treatment. This case suggests that pre-treatment dynamic contrast-enhanced imaging used in conjunction with T2-weighted imaging may improve the criteria for selecting uterine fibroids amenable to treatment with MRgFUS, potentially leading to improved patient outcomes.
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Dissertations / Theses on the topic "Fibroina"

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Nogueira, Grinia Michelle. "Hidrogeis e filmes de fibroina de seda para fabricação ou recobrimento de biomateriais." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267124.

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Orientador: Marisa Masumi Beppu
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
Made available in DSpace on 2018-08-12T12:02:05Z (GMT). No. of bitstreams: 1 Nogueira_GriniaMichelle_D.pdf: 10640071 bytes, checksum: 8b97ea00f684c6df573ea7e1ab6cc530 (MD5) Previous issue date: 2009
Resumo: Hidrogéis e filmes de fibroína de seda foram preparados e caracterizados com o objetivo de avaliar sua potencial aplicação no campo de biomateriais. Hidrogéis foram obtidos durante a etapa de diálise da solução de fibroína de seda e suas propriedades físicas, químicas, citotoxicidade e potencial de calcificação in vitro foram determinados. Esses materiais apresentaram estrutura tridimensional porosa com resistência mecânica à compressão relativamente alta e grande potencial de calcificar in vitro, sendo possíveis candidatos à aplicação na área de regeneração óssea. Filmes de fibroína de seda com quitosana foram preparados utilizando-se a técnica "Layer-by-Layer". Com esta técnica, foi possível depositar filmes anisotrópicos, com fibras alinhadas na superfície de substratos de silício. Como os biopolímeros em estudo são conhecidamente biocompatíveis, o alinhamento de fibras na superfície do substrato poderia ser explorado como um meio de guiar a adesão e proliferação celular ou ainda agregar resistência mecânica a outros filmes poliméricos. Filmes de fibroína de seda foram também empregados para recobrir pericárdio bovino utilizado na fabricação de válvulas cardíacas. Amostras recobertas com fibroína de seda foram avaliadas quanto à sua propensão à calcificação in vitro e os filmes foram testados quanto a sua citotoxicidade e potencial de adesão e crescimento de células endoteliais. Os resultados indicaram que filmes de fibroína de seda não apresentam citotoxicidade, são compatíveis com células endoteliais e não induzem a calcificação do pericárdio bovino recoberto durante os testes in vitro. Assim, o recobrimento com fibroína de seda pode ser uma alternativa de tratamento do pericárdio bovino para funcionalização da sua superfície. Dos resultados apresentados, concluiu-se que tanto hidrogéis como filmes derivados de fibroína de seda podem ser aplicados no campo de biomateriais, sejam como matrizes para reconstituição óssea, ou filmes para recobrimento e funcionalização da superfície de materiais.
Abstract: Silk fibroin hydrogels and films were prepared and characterized in order to investigate their potential application in the biomaterials field. The hydrogels were obtained during the dialysis step and their physical and chemical characteristics, cell toxicity and compatibility and potential to calcify in vitro were investigated. Those materials presented a porous tridimensional structure, mechanical strength and ability to deposit calcium phosphate crystals during in vitro calcification tests; therefore, silk fibroin hydrogels can probably be used in the bone regeneration field. Silk fibroin films were obtained by using the Layer-by-Layer technique. Bidirectional alignment of silk fibroin fibers was designed by adjusting the substrate position during the dipping process. A potential application to films with alignment of fibers is to guide cell adhesion and proliferation, since the biopolymers used to build the films are known as biocompatible materials. Silk fibroin films were also used to coat bovine pericardium used to fabricate cardiac valves. The coated samples were characterized by in vitro calcification tests and biocompatibility of silk fibroin films was evaluated by citotoxicity tests and their ability to adhere and grow of endothelial cells. The results showed that silk fibroin films are biocompatible and do not induce calcification during in vitro calcification tests, being suitable to coatand functionalize bovine pericardium surface. From the presented results, it can be concluded that silk fibroin hydrogels and films are suitable materials to be explored in the biomaterials field, for bone regeneration or biomaterials surface coating.
Doutorado
Engenharia de Processos
Doutor em Engenharia Química
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Chiarapini, Giordano. "La fibroina della seta come biomateriale per la medicina neurorigenerativa." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6249/.

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Una delle grandi sfide della medicina moderna e dell’ingegneria biomedica è rappresentata dalla rigenerazione e il recupero dei tessuti nervosi. I danni al Sistema Nervoso Centrale (SNC) e Periferico (SNP) provocano effetti irreversibili e influiscono sulla qualità della vita dei pazienti. L’ingegneria tissutale è stata definita come “un campo interdisciplinare che applica i principi dell’ingegneria e delle scienze della vita per lo sviluppo di sostituti biologici che ripristinino, mantengano, o migliorino la funzione di un tessuto o di un intero organo” (Langer R et al, 1993). Lo sviluppo dei biomateriali, i progressi scientifici nel campo delle cellule staminali e dei fattori di crescita, nonché le migliorie nelle tecniche di differenziazione e del rilascio dei farmaci offrono nuove opportunità di sviluppo terapeutico. Sono stati infatti creati tessuti in laboratorio attraverso la combinazione di matrici extracellulari ingegnerizzate, comunemente definite scaffold, cellule e molecole biologicamente attive. Tali “impalcature”, forniscono un supporto fisico e biochimico alla crescita delle cellule nervose. In quest’ottica si configura come essenziale il contributo della seta e di una sua particolare molecola: la fibroina. Quest’ultima grazie alle specifiche caratteristiche di biocompatibilità, lenta degradabilità e alle notevoli proprietà meccaniche, è stata ampiamente studiata, in anni recenti, per nuove applicazioni in ambito biomedico, come nel caso dell’ingegneria dei tessuti e del rilascio di farmaci. La fibroina della seta utilizzabile in vari formati quali film, fibre, reti, maglie, membrane, gel e spugne supporta l'adesione, la proliferazione e la differenziazione in vitro di diversi tipi di cellule. In particolare studi recenti indicano che la seta ha una buona compatibilità per la crescita di cellule neuronali dell'ippocampo. In questo elaborato saranno presentate le caratteristiche della fibroina della seta come biomateriale, con particolare riferimento all’ingegnerizzazione e al processo di fabbricazione degli scaffold finalizzati al supporto della rigenerazione cellulare – neuronale in caso di insulti traumatici, acuti e/o cronici del Sistema Nervoso.
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Rojas, Jose Eduardo Ulloa. "Preparation and characterization of fibroin hydrogels for potential application in photodynamic therapy." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Wendel Andrade Alves
Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Nanociências e Materiais Avançados, 2017.
A pesquisa em materiais naturais aumentou notavelmente nos últimos anos devido à oportunidade de combinar biocompatibilidade com propriedades físicas, mecânicas e químicas excepcionais, o que seria árduo para obter seguindo uma rota sintética. Entre estes polímeros naturais, a fibroína de seda é atraente por sua transparência óptica, excelente robustez mecânica e compatibilidade com sistemas vivos, com a formação de produtos de degradação não inflamatória. Neste estudo, fomos capazes de formar hidrogéis translucidos a partir de fibras de seda crua em diferentes concentrações e usamos como matriz para incorporar uma molécula fotossensível : sódio (4,4 ', 4' '- (20- (4- (3-carboxipropanamido ) Fenil) porfirina-5,10,15-triil) tribenzenossulfonato - para uso futuro na terapia fotodinâmica. Os hidrogéis obtidos foram caracterizados por diferentes técnicas de reologia e análise de espectrofotometria para estudar os fatores envolvidos na formação do hidrogel e para obter informações sobre propriedades da fibroína da seda (SF) após a adição da molécula de porfirina na matriz. O conjunto de resultados obtidos mostrou que os hidrogéis SF têm um comportamento de desbaste de cisalhamento, onde a viscosidade do gel diminui com o aumento da taxa de cisalhamento e que pode ser classificado como materiais tixotrópicos, o que significa que a estrutura do material precisa de tempo para se recuperar após a deformação de cisalhamento da experiência. Além disso, observamos que a estrutura secundária da fibroína não é afetado pela adição de porfirina em qualquer concentração, foi confirmado pelo sinal negativo de Cotom em torno de 220 nm nos espectros de dicroísmo circular. As nanofibras de fibroína porfirina híbridas foram capazes de gerar oxigênio singlete após a gelificação, e provamos que os hidrogéis de fibroína de seda são uma excelente matriz para encapsular outras moléculas para aplicação em terapia fotodinâmica e terapia fototérmica, levando à formação de nanoestruturas de péptido auto-montadas com efeitos fototerapêuticos controláveis.
The research in to natural materials has notably increased in recent years due to the opportunity of combining biocompatibility with exceptional physical, mechanical, and chemical properties, which would be arduous to obtain following a synthetic route. Among these natural polymers, silk fibroin is attractive because of its optical transparency, outstanding mechanical robustness and compatibility with living systems, with the formation of non-inflammatory degradation products. In this study, we were capable to form translucid hydrogels from raw silk fibers at different concentrations and used them as matrix to incorporate a photosensitive molecule - sodium (4,4',4''-(20-(4-(3- carboxypropanamido) phenyl) porphyrin-5,10,15-triyl) tribenzenesulfonate - for future use in photodynamic therapy. The obtained hydrogels were characterized by different rheology techniques and spectrophotometry analysis to study the factors that are involved in the formation of the hydrogel, and to have information about silk fibroin (SF) properties after adding the porphyrin molecule to the matrix. The set of obtained results showed that the SF hydrogels have a shear thinning behavior, where the viscosity of the gel decrease whit the increase of the shear rate, and that it can be classified as thixotropic materials. This mean that the structure of the material needs time to recover after experience shear deformation. Also, we observed that the secondary structure of the fibroin is not affected by the addition of porphyrin in any concentration, it was confirmed by the negative Cotton signal around 220 nm in the circular dichroism spectra. The hybrid porphyrin-fibroin nanofibers were capable to generate singlet oxygen after gelification, and we proved that silk fibroin hydrogels are an excellent matrix to encapsulate other molecules to application in photodynamic therapy and photothermal therapy, leading to the formation of selfassembled peptide nanostructures with controllable phototherapeutic effects.
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Márquez, Maqueda Augusto. "Alginate and silk fibroin based technologies for biosensing." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670117.

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A causa de el fort impacte de la diabetis com a malaltia d’extensió mundial ia les perspectives d’increment en el nombre de persones afectades durant els propers anys, especialment en països subdesenvolupats, hi ha una gran necessitat de producció de sistemes de detecció i quantificació de glucosa, que puguin ser implementats en dispositius portables robustos, miniaturitzats, de baix cost i llarga durada, tipus Point of Care (POC). En aquest sentit, en aquesta tesi es proposa l’ús de biomaterials d’origen natural, com l’alginat i la fibroïna de seda, procedents de l’alga bruna (classe Phaeophyceae) i de l’cuc de seda (Bombyx mori) respectivament, i la seva combinació amb tecnologies de microfabricació per a la producció d’una nova generació de dispositius POC.
Debido al fuerte impacto de la diabetes como enfermedad de extensión mundial y a las perspectivas de incremento en el número de personas afectadas durante los próximos años, especialmente en países subdesarrollados, existe una gran necesidad de producción de sistemas de detección y cuantificación de glucosa, que puedan ser implementados en dispositivos portables robustos, miniaturizados, de bajo coste y larga duración, tipo Point of Care (POC). En ese sentido, en esta tesis se propone el uso de biomateriales de origen natural, como el alginato y la fibroína de seda, procedentes del alga parda (clase Phaeophyceae) y del gusano de seda (Bombyx mori) respectivamente, y su combinación con tecnologías de microfabricación para la producción de una nueva generación de dispositivos POC.
Due to the impact of diabetes as a worldwide disease and the expected increment in the number of people affected in the following years, especially in underdeveloped countries, there is a need for the production of precise and long-life glucose biosensors to be implemented in simple, low-cost, robust, miniaturized and portable point of care systems. In that sense, this thesis proposes the use of biomaterials of natural origin, such as alginate and silk fibroin, from brown algae (Phaeophyceae class) and silkworm (Bombyx mori) respectively, and their combination with microfabrication technologies for the production of the new generation of electrochemial and optical point of care devices.
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5

Weska, Raquel Farias. "Estudo da esterilização e da calcificação in vitro de membranas de fibroina de seda para a aplicação como biomaterial." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267024.

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Orientador: Marisa Masumi Beppu
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: A fibroína de seda tem sido amplamente explorada para aplicações biomédicas, devido à sua biocompatibilidade, biodegradabilidade e mínima reação inframatória. A esterilização é uma etapa fundamental no processamento de biomateriais, e não deve alterar de forma negativa as propriedades funcionais dos dispositivos médicos. Estudos recentes verificaram que a fibroína pode ser utilizada como suporte para mimetizar a biomineralização, promovendo o crescimento de cristais de hidroxiapatita. O objetivo deste trabalho foi analisar a influência de diferentes métodos de esterilização nas características físicas, mecânicas e biológicas de membranas densas e porosas de fibroína de seda, e também estudar a possibilidade de aplicação de membranas de fibroína como biomaterial, pelo estudo da calcificação in vitro. Membranas densas e porosas de fibroína foram esterilizadas por radiação ultravioleta, etanol 70%, autoclave, óxido de etileno e radiação gama, e foram analisadas por MEV, FTIR-ATR, DRX, testes mecânicos e de citotoxicidade indireta. Para os ensaios de calcificação in vitro, as membranas de fibroína foram imersas em SBF por sete dias, e caracterizadas por MEV e EDX. Os resultados de esterilização mostraram que nenhum método ocasionou degradação das membranas ou a formação de produtos citotóxicos. Os métodos que utilizaram solvente orgânico, e aumento de umidade e/ou temperatura (etanol 70%, autoclave e óxido de etileno) tornaram as membranas densas mais cristalinas, e as membranas porosas mais estáveis, o que pode ser aproveitado quando se deseja que as membranas apresentem uma degradação in vivo mais lenta, dependendo da aplicação. Os resultados obtidos de calcificação in vitro indicaram que a fibroína pode induzir a calcificação, pela formação de depósitos de fosfato de cálcio com relações de Ca/P similares à da hidroxiapatita e seus precursores. A membrana porosa apresentou maior tendência à calcificação, quando comparada com a membrana densa, devido à sua rugosidade e porosidade, podendo desta forma ser considerada para aplicação em regeneração óssea.
Abstract: Silk fibroin has been widely explored for many biomedical applications, due to its biocompatibility, biodegradability and minimal inflammatory reactions. Sterilization is a fundamental step in biomaterials processing, and it must not alter in a negative way the functionality of medical devices. On the applicability of fibroin as a biomaterial, recent studies verified that fibroin can be used as a scaffold for mimicking biomineralization, promoting the growing of hydroxyapatite crystals. The aim of this study was to analyze the influence of different sterilization methods on physical, mechanical and biological characteristics of dense and porous silk fibroin membranes, and also to study the application of the fibroin membranes as biomaterials, through in vitro calcification studies. Dense and porous fibroin membranes were sterilized by ultraviolet radiation, 70% ethanol, autoclave, ethylene oxide and gamma radiation, and were analyzed by SEM, FTIR-ATR, XRD, mechanical and cytotoxicity tests. For in vitro calcification experiments, the fibroin membranes were soaked in SBF for seven days, and characterized by SEM and EDS. The results for sterilization indicated that none of the methods caused degradation or formation of cytotoxic substances. The methods that used organic solvent, and increase of humidity and/or temperature (70% ethanol, autoclave and ethylene oxide) increased the crystallinity of the dense membranes, and stabilized the porous membranes, characteristics that may be utilized when a slow in vivo degradation is desired, depending on the application. The calcification experiments indicated that silk fibroin may induce calcification, by forming calcium phosphate deposits with a Ca/P ratio similar to that of hydroxyapatite and its precursors. Porous membranes presented higher tendency to calcify, when compared to dense membranes, due to its surface roughness and high porosity, indicating that porous silk fibroin membranes may be considered for application in bone regeneration.
Mestrado
Engenharia de Processos
Mestre em Engenharia Química
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6

Martini, Mara. "Simulazione delle proprietà morfologiche e strutturali di materiali biologici ed organici per dispositivi elettronici ed optoelettronici." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15555/.

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Recentemente l’elettronica organica sta attraendo grande interesse, a causa della possibilità di produrre dispositivi a basso costo, flessibili, di grandi dimensioni e leggeri. In più sono sempre più numerosi gli studi che riportano l’utilizzo di uno o più materiali biologici nella fabbricazione di questi dispositivi, dal momento che crescono le richieste, soprattutto in ambito medico e ambientale, di strumenti capaci di interagire con il corpo umano e l’ambiente esterno. Per cercare quindi di potenziare l’efficienza di dispositivi organici e bio-organici è utile ottimizzare le proprietà elettroniche e morfologiche dei materiali costituenti il dispositivo. Per fare ciò risultano molto utili studi computazionali che permettono di comprendere la correlazione tra proprietà morfologiche ed elettroniche. In questo lavoro di tesi sono stati studiati due materiali: la fibroina, proteina maggioritaria estratta dalla seta del baco Bombyx mori, come materiale dielettrico e il PTCDI-C13, un composto organico derivato dalla perilene diimmide, come materiale semiconduttore. Questi due materiali formano gli strati attivi di un bio-OFET. Al fine di investigare le proprietà morfologiche strutturali di questi materiali sono state utilizzate le tecniche di simulazione di dinamica molecolare. Sono stati effettuati studi morfologici sulle rugosità superficiali e strutturali, analizzando le proprietà morfologiche e strutturali dei materiali e delle relative interfacce, anche in relazione ai vari trattamenti termici simulati al fine di poter correlare il processing al miglioramento delle performance globali. In più, dal momento che il PTCDI-C13 è un materiale cristallino, si è cercato anche di stabilire l’ordine locale degli aggregati di PTCDI-C13 depositati su fibroina. Le simulazioni hanno inoltre evidenziato un miglioramento della morfologia della superficie esposta rispetto alla fibroina isolata, marcando il ruolo fondamentale che ha questo strato nell’architettura OFET.
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7

Aciari, Juliana Raquel Frigo. "Preparação de micropartículas de fibroína da seda calcificadas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-28112013-091351/.

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A calcificação ocorre pela formação de depósitos de cálcio em diferentes matrizes envolvendo fatores mecânicos, químicos e biológicos. Alguns compósitos, polímeros e proteínas são utilizados na formação de matrizes por promover maior eficiência no processo de mineralização. Estima-se que a fibroína da seda apresente também esta finalidade. A fibroína é uma proteína fibrosa extraída do casulo do bicho-da-seda (Bombyx mori), que pode ser processada como filme, membrana, esponja, pó, gel e aplicada em ossos e cartilagens, enxertos vasculares, reparação de nervos e córnea, como sistema de liberação de drogas, suturas, ligamentos, peles, tendões e substrato para cultura de células. Nesse trabalho houve a preparação de micropartículas de fibroína da seda através de dois procedimentos distintos, um por borrifamento em N² e outro por borrifamento em Na2HPO4 e o processo de calcificação realizado foi por imersão alternada de soluções tamponadas de cálcio e fosfato. As caracterizações realizadas foram Espectroscopia de Absorção no Infravermelho (FT-IR), Análise Termogravimétrica (TGA), Microscopia Eletrônica de Varredura (MEV), Espectroscopia de Energia Dispersiva (EDS) e Calorimetria Exploratória Diferencial (DSC). Os resultados obtidos mostraram que a calcificação das micropartículas de fibroína ocorre pelas duas metodologias empregadas. O teor de calcificação foi de aproximadamente 29% para micropartículas borrifadas em N² e de aproximadamente 80% para as micropartículas borrifadas em Na2HPO4. As micropartículas de fibroína calcificadas, não apresentaram transição térmica até a temperatura de 120°C, possibilitando a esterilização em autoclave a seco.
Calcification occurs by the formation of calcium deposits in different matrices involving mechanical factors, chemical and biological. Some composites, polymers, and proteins are used in forming matrices to promote higher efficiency in the process of mineralization. It is estimated that the silk fibroin also present for this purpose. The fibroin is a fibrous protein extracted from silkworm cocoon silkworm (Bombyx mori), which can be processed as film, membrane, sponge, powder, gel and applied in bone and cartilage, vascular grafts, nerve repair and corneal as a delivery system for drugs, sutures, ligaments, skins, tendons and substrate for cell culture. In this work was the preparation of microparticles of silk fibroin by two different procedures, sputter under N² and in other sputter Na2HPO4 and calcification process was performed by immersion of alternating buffered solutions of calcium and phosphate. The characterizations were performed Absorption Spectroscopy Infrared (FT-IR), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS) and Differential Scanning Calorimetry (DSC). The results showed that the calcification of fibroin microparticles occurs by the two methodologies. The calcified fibroin microparticles showed no thermal transition temperature to 120°C, enabling autoclaving of the microparticles dry
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Bexiga, Natália Marchesan. "Preparo e avaliação comparativa das propriedades físico-químicas de hidrogéis de fibroína de seda com conteúdo variado de sericina obtidos a partir dos cloretos de cálcio e lítio em sistemas distintos de solventes." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-19092014-093819/.

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A fibroína de seda é uma proteína sintetizada pela espécie Bombyx mori, popularmente conhecida como bicho-da-seda. O casulo de Bombyx mori é composto por fibras de fibroína e pela sericina, responsável por unir os fios de fibroína. A fibroína é um polímero natural bastante versátil e pode ser processada de maneira a formar materiais como filmes, microesferas e hidrogéis. Os hidrogéis são redes tridimensionais formadas por macromoléculas e capazes de absorver grande quantidade de água sem perder sua integridade estrutural. Devido à características como biocompatibilidade, elevado teor de água e boas propriedades de difusão de oxigênio e nutrientes, os hidrogéis são amplamente utilizados em pesquisa biomédica. A fibroína é biodegradável, termicamente estável, altamente cristalina, flexível, resistente à tração, além de insolúvel em água e na maioria dos solventes orgânicos. A fibroína derivada das sedas Frison Extra e Meada 21 Denier foi separada da sericina pelo processo de degomagem, onde as fibras de seda foram imersas em soluções alcalinas e submetidas à aquecimento com posterior remoção de sericina. Os fios de fibroína foram dispersos nas soluções de CaCl2:H2O, LiCl:H2O e LiCl:EtOH:H2O. Diferenças nos tempos de dispersão para amostras distintas degomadas ou não foram observadas, bem como para cada um dos sistemas salino/solvente empregados. Após o processo de dispersão da fibroína as dispersões obtidas foram caracterizadas quanto à textura e reologia. As amostras não degomadas apresentaram maior firmeza e aumento do módulo elástico G\'. Algumas amostras contendo sericina ou etanol apresentaram comportamento newtoniano. Em uma segunda etapa, as amostras foram dialisadas para a produção do hidrogel e em seguida liofilizadas. Não houveram diferenças entre os tempos de gelificação para amostras distintas. Finalmente objetivou-se a caracterização dos hidrogéis obtidos por meio de ensaios termogravimétricos, difratométricos, espectrofotométricos e microscópicos. Todos os hidrogéis de fibroína de seda apresentaram alta resistência térmica, com presença predominante da conformação em folha-β da fibroína. Morfologicamente, os hidrogéis obtidos a partir de dispersões em LiCl:EtOH:H2O e CaCl2:EtOH:H2O apresentaram aspecto de rede enovelada, enquanto que os hidrogéis oriundos de dispersões em LiCl:H2O apresentaram estrutura lamelar.
The silk fibroin is a protein synthesized by Bombyx mori species, popularly known as silkworm silk. The Bombyx mori cocoon is composed of fibroin fibers and the sericin protein, which is responsible for joining the fibroin yarns. The fibroin is a quite versatile natural polymer and can be processed to form materials such as films, microspheres and hydrogels. Hydrogels are three-dimensional networks formed by macromolecules and capable of absorbing large quantities of water without losing their structural integrity. Due to biocompatibility, ability to mimic biological tissues, high water content and good diffusion properties of oxygen and nutrients, hydrogels are widely used in biomedical research. The fibroin is biodegradable, thermally stable, highly crystalline, flexible and tensile resistant. Besides, it is insoluble in water and in most organic solvents. The fibroin from Frison Extra and Meada 21 Denier silks was separated from the sericin by the degumming process, whereby the silk fibers were immersed in alkaline solutions and subjected to heating with subsequent dissolution and removal of sericin. Fibroin yarns were dispersed in various solutions: CaCl2:H2O; LiCl:H2O; and LiCl:EtOH:H2O. It was observed that according to the fibroin type and solvent solution used the time to achieve dispersion varied. Texture and rheology were determined for every sample after dispersion. All non-degummed samples had shown increased firmness and elastic module G\'. It was observed that the samples presented a wide behavior range, some that contained sericin or ethanol presented Newtonian behavior. Subsequently the samples were dialyzed to obtain the hydrogels and lyophilized. All samples (with exception of two) have formed hydrogels in a 24 hours period. The lyophilized hydrogels were analyzed by thermogravimetry, diffractometry, spectrophotometry and microscopy. All silk fibroin hydrogels presented high thermic resistance with β-sheet predominance. Morphologically, all hydrogels obtained from LiCl:EtOH:H2O and CaCl2:EtOH:H2O solutions had shown entangled aspect wile hydrogels from LiCl:H2O solutions had shown lamellar structures.
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9

Pugina, Roberta Silva. "Estudo de fibroína dopada com terras raras para potenciais aplicações fotônicas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-28032018-131311/.

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A fibroína da seda (SF) é uma proteína estrutural encontrada nos casulos do Bombyx mori e que possui propriedades potencialmente aplicáveis em fotônica. Esta matriz biocompatível é um substrato interessante para diferentes íons ou moléculas; além disso, o seu índice de refração variável permite que fótons sejam guiados neste material, possibilitando seu uso como guias de ondas biocompatíveis e reabsorvíveis, que pode ser utilizado para fornecer energia ótica para diversas aplicações, por exemplo, terapia ou imagem dentro de tecidos vivos. A sua boa adequação em sistemas ópticos deve-se principalmente a propriedades como: ser mecanicamente robusta, apresentar superfícies muito lisas, altamente transparentes (> 95%) em toda a região visível do espectro e ser modelável. Além disto, há uma característica adicional: a viabilidade de funcionalização bioquímica, o que pode conferir uma maior versatilidade a estes dispositivos. Já os íons terras raras (TR) possuem um papel amplamente conhecido no ramo da fotônica; porém, não há nenhum estudo envolvendo a produção de luz em SF dopada com íons TR, e a combinação das propriedades mecânicas e óticas desta matriz com a multifuncionalidade destes íons pode ser uma forma de se produzir dispositivos fotônicos novos e distintos. Desta forma, o presente trabalho teve como objetivo estudar a estrutura da matriz de SF na presença de diferentes íons TR (Eu3+ e Tb3+), bem como a interação existente entre os aminoácidos que constitui a matriz e estes íons. Os resultados apresentados nesta dissertação mostraram as interações TR-SF e suportam os mecanismos de transferência de energia para excitação de diferentes íons TR nesta matriz, sendo importante para futuras aplicações em fotônica
Silk fibroin (SF) is a structural protein found in Bombyx mori cocoons and has properties that are potentially applicable in photonics. This biocompatible matrix is an interesting substrate for different ions or molecules. Furthermore, its variable refractive index allows for photons to be guided in this material enabling their use as biocompatible and resorbable waveguides, which can be used to provide optical energy for various applications, e. g., therapy or imaging into living tissue. Its suitability in optical systems is mainly due to its properties such as: being mechanically robust, presenting very smooth surfaces, highly transparent (> 95%) throughout the visible region of the spectrum and being moldable. In addition, there is an extra feature: the possibility of biochemical functionalization, which may confer greater versatility to these devices. On the other hand, rare earth ions (RE) play a widely known role in the field of photonics. However, there is no studies involving the production of light in doped SF with RE ions and the combination of the mechanical and optical properties of this matrix with the multifunctionality of these ions can be a way to produce new photonic devices. Thus, the aim of the present work was to study the SF matrix structure in the presence of different RE ions (Eu3+ and Tb3+) as well as the interaction between the amino acids from the matrix and these RE ions. The results presented in this manuscript have characterized the RE-SF interactions and supported the mechanisms of energy transfer for excitation of different RE ions in this matrix being important for future applications in photonics
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Caetano, Laís Galvão [UNESP]. "Propriedades ópticas de membranas à base de polímeros naturais e nanopartículas de carbono." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148739.

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A fibroína da seda extraída dos casulos do bicho-da-sêda é um co-polímero particularmente atraente para aplicações em dispositivos fotônicos e opticoeletrônicos devido a sua transparência óptica, biocompatibilidade e propriedades mecânicas. Esta tese apresenta a obtenção de suspensões e filmes iridescentes-luminescentes de fibroína contendo nanopartículas luminescentes de carbono (“carbon dots”) obtidos a partir de carvão vegetal. As nanopartículas luminescentes de carbono apresentam biocompatibilidade, baixa toxicidade, propriedades de fotoluminescência interessantes e possibilidade de modificação da superfície. Redes de difração foram produzidas nestes filmes utilizando como molde um DVD comercial. Os materiais obtidos foram caracterizados por um conjunto de técnicas de análise: Microscopia de Força Atômica (AFM), Microscopia Eletrônica de Varredura (MEV), Microscopia Eletrônica de Transmissão (MET), Espectroscopia de absorção na região do UVVis, Espectrofotometria de absorção molecular na região do infravermelho com transformada de Fourier (FTIR) e Luminescência. Medidas de luminescência mostram que os carbon dots emitem múltiplas cores entre toda a região do visível. Planos cristalinos foram observados nas imagens de MET das nanopartículas, no qual foram asssociadas a estrutura do grafite. Pela análise de UV-Vis dos carbon dots observou-se que a absorção óptica decai gradualmente à medida em que ocorre deslocamento para o vermelho e para os filmes de fibroína observou-se um ombro referente a transição eletrônica da tirosina (aminoácido de sua composição). A partir dos espectros de FTIR observou-se que não houve mudança na estrutura da fibroína após a adição dos carbon dots. As imagens de AFM e MEV comprovam a presença dos micropadrões periódicos na superfície dos filmes. Os resultados mostraram que os filmes de fibroína contendo carbono dots tem um grande potencial para a biomedicina, principalmente devido os seus parâmetros de luminescência se extenderem em toda a região do visível e por apresentar uma matriz sustentável, com excelentes propriedades ópticas e mecânicas.
Silk fibroin extracted from silkworm cocoons is a particularly attractive copolymer for applications in photonics and optoelectronics devices due its optical transparency, biocompatibility and high mechanical strength. This thesis presents the preparation of suspensions and iridescent-luminescent films of silk fibroin containing luminescent carbon nanoparticles (carbon dots) obtained from vegetal coal. Luminescent carbon nanoparticles present high biocompatibility, low toxicity, interesting photoluminescence properties and possibility of surface modification. Diffraction gratings were produced in these films using a commercial DVD as a template. The materials obtained were characterized by a set of analysis techniques: Atomic-Force Microscopy (AFM), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), UV-Visible Spectroscopy, Fourier transform infrared spectroscopy (FTIR), and Luminescence. Luminescence measurements show that carbon dots emit light at the entire visible region. Crystalline planes were observed in the TEM images of the nanoparticles, where upon the graphite structure was associated. By analyzing the UV-Vis spectra of the carbon dots it was observed that the optical absorption gradually decreases as the red shift occurs. In the UV-Vis spectra of the silk fibroin films it was observed a shoulder referring to the electronic transition of the tyrosine (amino acid of its composition). From the FTIR spectra it was observed that there was no change in the silk fibroin structure after addition of the carbon dots. The AFM and SEM images confirm the presence of the periodic micro-patterns on the surface of the films. The results showed that the silk fibroin films containing carbon dots have a great potential for biomedicine, mainly due to its luminescence parameters extending throughout the visible region and due to a sustainable platform with excellent optical and mechanical properties.
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Books on the topic "Fibroina"

1

Segars, James. Fibroids. Chichester, West Sussex: John Wiley & Sons, 2013.

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Segars, James H., ed. Fibroids. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.

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Dubuisson, Jean-Bernard. Uterine fibroids. Paris: Arnette, 1997.

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Moawad, Nash S., ed. Uterine Fibroids. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-58780-6.

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Lark, Susan M. Fibroid tumors & endometriosis. Los Altos, CA: Westchester Pub. Co., 1993.

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Sugino, Norihiro, ed. Uterine Fibroids and Adenomyosis. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7167-6.

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Mayfield, Eleanor. Choosing a treatment for uterine fibroids. [Rockville, MD: Food and Drug Administration, 1994.

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Mayfield, Eleanor. Choosing a treatment for uterine fibroids. [Rockville, MD: Food and Drug Administration, 1994.

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Parker, James N., and Philip M. Parker. The official patient's sourcebook on uterine fibroids. Edited by Icon Group International Inc. San Diego, Calif: Icon Health Publications, 2002.

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Greig, Lloyd B. 100 questions and answers about uterine fibroids. Sudbury, Mass: Jones and Bartlett Publishers, 2010.

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Book chapters on the topic "Fibroina"

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Krafsur, E. S., R. D. Moon, R. Albajes, O. Alomar, Elisabetta Chiappini, John Huber, John L. Capinera, et al. "Fibroin." In Encyclopedia of Entomology, 1423. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_3794.

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Asakura, Tetsuo, and Yu Suzuki. "Silk Fibroin." In Encyclopedia of Polymeric Nanomaterials, 2228–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-29648-2_323.

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Asakura, Tetsuo, and Yu Suzuki. "Silk Fibroin." In Encyclopedia of Polymeric Nanomaterials, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36199-9_323-1.

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Leppert, Phyllis, Mazen Fouany, and James H. Segars. "Understanding Uterine Fibroids." In Fibroids, 1–10. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch1.

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Heitmann, Ryan J., Cindy M. P. Duke, William H. Catherino, and Alicia Y. Armstrong. "Surgical Treatments and Outcomes." In Fibroids, 109–19. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch10.

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Cookingham, Lisa Marii, Alicia Y. Armstrong, Aradhana Venkatesan, and James H. Segars. "Rare Fibroid Syndromes." In Fibroids, 120–33. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch11.

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Christman, Gregory M., Courtney A. Marsh, and Elizabeth J. Campbell. "Counseling the Patient with Uterine Fibroids." In Fibroids, 134–44. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch12.

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Younger, Joshua, K. Maravet Baig-Ward, James H. Segars, and Ayman Al-Hendy. "The Clinical Spectrum of Fibroid Disease." In Fibroids, 11–23. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch2.

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Nodler, James L., and James H. Segars. "Evidence-Based Indications for Treatment of Uterine Fibroids in Gynecology." In Fibroids, 24–35. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch3.

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Johnson, Natalie L., Errol Norwitz, and James H. Segars. "Management of Fibroids in Pregnancy." In Fibroids, 36–53. Oxford: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118456996.ch4.

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Conference papers on the topic "Fibroina"

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Abdulhafez, Moataz, Se Youn Cho, Golnaz Tomaraei, and Mostafa Bedewy. "Microwave-Assisted Processing of Regenerated Silk Fibroin Films." In ASME 2019 14th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/msec2019-2932.

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Abstract Regenerated silk fibroin (RSF) is an emerging material derived from natural silk. Thin RSF films are transparent, biocompatible and biodegradable, which makes them suitable for many applications, such as flexible/conformal and transient electronics, bioresorbable devices, bioresists for lithography, and edible food protective coatings. To realize these applications, controlling and tuning the properties of RSF films is required to fully exploit their unique mechanical, optical, and degradation properties. Here, a new approach for tuning these properties is presented based on inducing rapid molecular structure transformations in fibroins via microwave heating. Transparent RSF films were post-treated by microwave irradiation, resulting in the transition of amorphous silk fibroin structure to a more α-helix dominant secondary structure. By increasing the microwave irradiation duration, an increase of helix secondary structure was observed. We use amide-I band Fourier-transform infrared spectroscopy (FTIR) of the films to characterize the secondary structure of fibroins. Moreover, we show that silicon substrates coated with 100 nm thick RSF films by spin casting, exhibit higher stability in water after microwave irradiation for up to 10 minutes, confirming a conformational change in the RSF secondary structure towards more stable α-helical rich motifs. Our results show that microwave treatment can be a new high throughput approach for tailoring the properties and structure of functional RSF-based films in a scalable and sustainable manufacturing process, when compared to other post processing techniques.
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Domachuk, Peter. "Silk Fibroin Optofluidics." In Frontiers in Optics. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/fio.2011.ftue2.

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Song, Ruoyuan, Haruhiro Ino, and Teruo Kimura. "Mechanical Properties of PBS Plastic Reinforced by Paper Using Waste Silk." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12742.

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Considering the efficient recycling of waste silk resource, the biodegradable composite consisting of PBS matrix and pure silk paper was prepared by hot compression molding. Beating treatment is adopted to modify silk fibroin and enhance the composite, and the corresponding mechanical properties and morphologies were studied detailedly. The results showed that beating treatment could realize the fibrillation of fibroin and improve the paper’s tensile strength, and proper beating treatment to fibroin could also improve the mechanical properties of silk paper reinforced PBS composite. The tensile, flexural and impact resistance properties of this green composite were improved remarkably with fiber loading increasing. Especially for impact resistance, it was improved 154% at 40 wt% fiber loading compared with PBS control.
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Lawrence, B., H. Perry, P. Domachuk, M. Cronin-Golomb, I. Georgakoudi, D. L. Kaplan, and F. G. Omenetto. "Silk fibroin-based active optofluidics." In 2008 Conference on Lasers and Electro-Optics (CLEO). IEEE, 2008. http://dx.doi.org/10.1109/cleo.2008.4551560.

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Applegate, Matthew B., Alexander N. Mitropoulos, Giovanni Perotto, David L. Kaplan, and Fiorenzo G. Omenetto. "Biocompatible Silk Fibroin Optical Fibers." In Novel Optical Materials and Applications. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/noma.2015.nt1b.4.

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Nagarkar, Shailesh, Ashish Lele, Christophe Chassenieux, Taco Nicolai, Dominique Durand, Albert Co, Gary L. Leal, Ralph H. Colby, and A. Jeffrey Giacomin. "Gelation of Regenerated Fibroin Solution." In THE XV INTERNATIONAL CONGRESS ON RHEOLOGY: The Society of Rheology 80th Annual Meeting. AIP, 2008. http://dx.doi.org/10.1063/1.2964769.

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Nayak, V. H., H. Batra, J. K. Thachuthara-George, and K. B. Turner. "Idiopathic Fibrosing Mediastinitis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7184.

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Gary, P. J., B. A. Hirsh, N. Salam, and L. W. Greenspon. "Post-Histoplasmosis Fibrosing Mediastinitis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6882.

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Otaka, Akihisa, Kazuya Takahashi, Kenji Isshiki, Yusuke Kambe, Katsura Kojima, Yasushi Tamada, and Naohide Tomita. "How do chondrocytes aggregate on fibroin substrate." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6609522.

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Asha, S., N. Parushuram, K. S. Harish, S. Ganesh, and Y. Sangappa. "Radiation induced effects on silk fibroin films." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122576.

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Reports on the topic "Fibroina"

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Mameti, Lilian. Open Hysterectomy for a Patient with Fibroids. Touch Surgery Publications, August 2019. http://dx.doi.org/10.18556/touchsurgery/2016.s0167.

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Mameti, Lilian. Open Hysterectomy for a Patient with Fibroids. Touch Surgery Simulations, August 2019. http://dx.doi.org/10.18556/touchsurgery/2019.s0167.

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Velentgas, Priscilla, Donna Messner, and Evan Myers. Comparing Patient-Centered Outcomes after Treatment for Uterine Fibroids. Patient-Centered Outcomes Research Institute (PCORI), May 2018. http://dx.doi.org/10.25302/5.2018.ce.12114430.

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Gao, Li-nan, Lian-gang Ge, Ming-zhe Zhu, and Xin-xin Yao. Association between tumor necrosis factor α and uterine fibroids: a protocol of systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0010.

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Liu, Lu, Tianfu Wang, and Baiying Lei. High-intensity focused ultrasound ablation versus surgical interventions for the treatment of symptomatic uterine fibroids: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2020. http://dx.doi.org/10.37766/inplasy2020.8.0012.

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