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Bittencourt, Paulo Rodrigo Stivial, Luciano Moura de Souza, Natália Zanotelli, and Fernando Reinoldo Scremin. "Incorporação de fibroina de Bombyx mori e nanotubos em sistemas de poliamida 6." Acta Brasiliensis 2, no. 3 (September 12, 2018): 106. http://dx.doi.org/10.22571/2526-4338118.
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A fibroina da seda é um biopolímero natural proveniente de Bombyx mori L. (bicho da seda) que possui excelente estabilidade térmica e resistência mecânica. Parte deste biopolimero é rejeitada no processo industrial devido a escolha de casulos viáveis para a produção de seda de qualidade. O objetivo dessa pesquisa foi reaproveitar o biopolímero natural proveniente de B. mori para produzir sistemas, processados por casting, de misturas de poliamida 6 com nanotubo de carbono funcionalizado com carboxila e a fibroina. O filme polimérico foi obtido por casting, utilizando ácido fórmico como solvente. As propriedades físico-químicas foram analisadas por Espectroscopia no Infravermelho, análise termogravimétrica e ensaios de tração mecânica. Os resultados das análises reportaram o aumento na estabilidade térmica e mecãnica dos filmes com a presença de fibroina e MWNT nos compósitos de poliamida 6, tendo atingido um módulo de elasticidade de 4,0 GPa com 0,025% em massa de nanotubo no compósito. Assim, a incorporação da fibroína, extraída de casulos considerados defeituosos, em compósito com poliamida 6 e nanotubo de carbono funcionalizado com carboxila melhorou a estabilidade mecânica nestes sistemas quando comparado a poliamida 6 pura, formando um sistema com potencial uso como material de engenharia.
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Caballero Méndez, Lyda, and Duverney Gaviria Arias. "Desarrollo y caracterización de películas de fibroina de seda para reparación condral." Revista Colombiana de Biotecnología 21, no. 1 (January 1, 2019): 71–81. http://dx.doi.org/10.15446/rev.colomb.biote.v21n1.73137.
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La fibroína de seda es una proteína que ha demostrado ser un biomaterial con gran potencial en medicina regenerativa, por suscaracterísticas de biocompatibilidad y su amplia posibilidad de modificación estructural permite ser usada como andamio favore-ciendo procesos de crecimiento, diferenciación celular y la regeneración del tejido afectado.En este estudio se utilizaron capullos de gusano de seda Bombyx moriL., para la fabricación de películas de fibroína, los capullos fueron desgomados utilizando Na2CO30,02M, la fibroína obtenida se disolvió con LiBr 9,3M, el cual fue eliminado mediante diáli-sis y finalmente la solución de fibroína fue concentrada mediante contradiálisis. La fibroína fue servida en cajas de poliestireno, se-cadas a 90°C/24 horas y esterilizadas con etanol al 70%. Células madre mesenquimales fueron sembradas sobre estas películas de fibroína e inducidas a diferenciación utilizando un medio condrogénico especifico. La diferenciación fue evaluada por triplicadoa los 14 y 21 días mediante extracción de ARN total, síntesis de ADN copia y amplificación por PCR de un grupo de genes específi-cos de cartílago empleando cebadores específicos.Se fabricaron películas de fibroína estables y resistentes que permitieron el crecimiento y la multiplicación celular, así como la dife-renciación condrogénica evidenciada por la expresión de genes condrogenicos, no se afectó la viabilidad ni el recuento celular, las células interactuaron con el andamio evidenciado por el área de tapizado formado sobre la superficie de la película de fibroína.Finalmente se concluye que la fibroína de seda es un biomaterial que puede servir de andamio potencial para la regeneración de lesiones articulares.
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Nadir qızı Kərimova, Sevinc. "Uterine fibroids." NATURE AND SCIENCE 07, no. 02 (April 23, 2021): 22–24. http://dx.doi.org/10.36719/2707-1146/07/22-24.
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Fibroids (especially large ones) deform the uterine cavity, compressing the fallopian tubes, making it difficult for sperm to move. In addition, in women with fibroids, in many cases, the hormonal background is disturbed, as a result of which a woman may not ovulate. The factors we have listed can lead to infertility in women. Doctors recommend women with fibroids to treat fibroids during the planning stage of pregnancy or, in some cases, to remove fibroids before pregnancy. A woman can plan a pregnancy 6 months after the fibroid is removed. Key words: fibroma, uterus, pregnancy
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Kovarik Antonović, Ivana. "Novim putovima svile prema održivoj alternativi za umjetnim kožnim materijalima." Koža & obuća 69, no. 3-4 (December 31, 2021): 16–18. http://dx.doi.org/10.34187/ko.69.3-4.4.
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Interes za ekološki prihvatljivijim modnim proizvodima znatno se povećao u zadnjih nekoliko godina kao posljedica ozbiljnog narušavanja ekološke ravnoteže uslijed ekološki nepovoljnih proizvodnih procesa. Znanstvenici Sveučilišta Tufts došli su do inovativnih rješenja u proizvodnji umjetne kože. Istraživanja su usmjerili prema biomaterijalu duge povijesti – svili. Proces izrade materijala nalik koži od svilenih vlakana uključuje razgradnju fibroina, temeljnog gradbenog polimera svile, na pojedinačne proteinske komponente u vodenoj otopini, dodatak drugih biopolimera i prirodnih aditiva te računalnu izradu (tehnologija 3D ispisa), koja omogućuje programiranje slojeva i nepravilne geometrijske uzorke. Nastali materijali pokazuju snažne, meke, savitljive, izdržljive i biorazgradive značajke, usporedive s tradicionalnim materijalima za izradu umjetne kože.
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Mijailovic, M. Z., and S. M. Lukic. "Intra-arterial embolisation of uterine fibroma." Acta chirurgica Iugoslavica 56, no. 4 (2009): 209–13. http://dx.doi.org/10.2298/aci0904209m.
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Uterine fibroid are benign tumors that consist most of the tumor occurrences in pelvic cavity of women. Possible courses of treatment include: medicament treatment, surgical and new intra-arterial embolisation method. The aim of the paper is to present achieved results in intra-arterial embolisation treatment of Uterine fibroid. Material and methods: A prospective study was performed in the period from October 2007 until October 2008. It included 36 women with symptomatic uterine fibroid. They were treated by intra-arterial embolisation. All patients had control MRI examinations after treatment. Embolisation was performed by 'cross-over' technique, using bilateral punction of femoral arteries, a selective catheterization a. uterine, and application of 750-900m Bead Blocks. Results: Average age of patients was 38.5 years. The most of fibroids had intramural localization (39%). solitary fibroids were seen in 56% of patients, multiple in 44%. Gynecological hemorrhage was the leading symptom with 34 patients (94%). One year after receiving intra-arterial embolisation treatment, fibroid regression of 50% was registered in all patients. There were no serious complications noted in our study, with the exception of postembolisation syndrome which occurred in 11 (30%) patients in a relatively mild form Conclusion: Intra-arterial embolisation of uterine fibroma is a method that in large percent of patients removes symptoms of uterine fibroma presence, prevents its growth, and safely helps women enter menopause when activity of hormone dependant tumor ceases.
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Salehi, Mohammadgharib, Nasrin Jalilian, Ayoub Salehi, and Mojgan Ayazi. "Clinical Efficacy and Complications of Uterine Artery Embolization in Symptomatic Uterine Fibroids." Global Journal of Health Science 8, no. 7 (December 18, 2015): 245. http://dx.doi.org/10.5539/gjhs.v8n7p245.
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<p>We decided to evaluate the efficacy and complications of uterine artery embolization (UAE) in patients with symptomatic uterine fibroids. Sixty-five premenopausal patients, without considering the fibroids size and its location, were treated by bilateral UAE. At baseline and after 3, 6, and 12 months MRI was obtained to determine the uterine length and fibroid diameter. In addition, symptoms of the patients were documented at these follow-up schedules. UAE was successful in 62 (95.4%) cases. Complete infarction rate of the fibroid was 83.1%. After 12 months, the uterine length showed a decrease of 55.7% (mean of 9.4 cm) and the diameter of the dominant fibroid revealed a decrease of 52.1% (mean of 3.4 cm). Menorrhagia improved in 45 cases (91.8%), abdominal mass in 24 cases (82.28%), urinary symptoms in 17 cases (85%), pelvic pain in 21 cases (84%), and dysmenorrhea in 25 cases (80.6%). At final follow-up performed after one year, complete infarction of the fibroma was demonstrated in 49 patients (83.1%). Two cases achieved successful pregnancy in the one year follow-up period. Five patients developed post-embolization syndrome which necessitated admission to the hospital. Twenty-two patients presented and complained of pain for which outpatient pain management was done. UAE was a successful treatment for uterine fibroids that preserved the uterus, had minimal complications, and required short hospitalization and recovery.</p>
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Jiang, Yu Chun, and Yuan Song Zhang. "Study on the Effect of Sericin Content on Solubility of Silk Fibroin and the Properties of Silk Fibroin Membranes." Applied Mechanics and Materials 319 (May 2013): 165–68. http://dx.doi.org/10.4028/www.scientific.net/amm.319.165.
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In this paper silkworm cocoon was dissolved at different time by degumming agents of NaHCO3 to obtain silk fibroins with different content of sericin. Then the silk fibroins was dissolved to get the silk fibroin membranes. The results indicated that the content of sericin had certain effect on silk solubility. As the content of sericin reduced, the dissolution speed was faster and the silk solubility was greater. The properties of the silk fibroin membranes with some sericin were much better than those degummed completely.
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Mailli, Leto, Eric Y. Auyoung, Salvatore A. Angileri, Seyed Ameli-Renani, Lakshmi Ratnam, Raj Das, Joo-Young Chun, Sourav Das, Isaac Manyonda, and Anna-Maria Belli. "Predicting the Fibroid-Migratory Impact of UAE: Role of Pre-embolization MRI Characteristics." CardioVascular and Interventional Radiology 43, no. 3 (October 24, 2019): 453–58. http://dx.doi.org/10.1007/s00270-019-02348-w.
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Abstract Aim To investigate potential factors on MR imaging that could be used to predict migration of uterine fibroids post-UAE. Methods and Materials We retrospectively reviewed patients referred for UAE having pre-procedural and 6 months post-procedural MRI, at a tertiary centre, over a 1-year period. Pre- and post-UAE images were reviewed in 64 women by two radiologists to identify the sub-type, dimensions, and infarction rate of each dominant fibroid. The shortest distance between the fibroid and the endometrial wall was measured to determine intramural fibroid movement. Paired sample T tests and two-sample T tests were used to compare between pre- and post-embolization variations and between migrated and non-migrated intramural fibroids, respectively. After preliminary results suggested potential predictors of intramural fibroids migration, we tested our findings against the non-dominant intramural fibroids in the same patients. Results Review of images revealed 35 dominant intramural fibroids, of which eight migrated to become submucosal fibroids, while five were either partially or completely expelled. These 13 migrated fibroids had a shorter pre-procedural minimum endometrial distance (range 1–2.4 mm) and greater maximum fibroid diameter (range 5.1–18.1 cm), when compared to non-migrating fibroids. On image reassessment, the migrated non-dominant intramural fibroids had a minimum endometrial distance and maximum fibroid diameter within the same range. Conclusion Intramural fibroids with a minimum endometrial distance less than 2.4 mm and a maximum fibroid diameter greater than 5.1 cm have a high likelihood of migrating towards the endometrial cavity after UAE.
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Knudsen, Nina Isabelle, Klaus-D. Wernecke, Heribert Kentenich, and Matthias David. "Comparison of Clinical Symptoms of Assumed vs. Actual Uterine Fibroids – Symptoms Described by Patients and Ultrasound Findings." Geburtshilfe und Frauenheilkunde 80, no. 03 (October 30, 2019): 316–23. http://dx.doi.org/10.1055/a-0991-0105.
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Abstract Purpose How many women assume that they have fibroids but are found not to have fibroids on ultrasound examination? How severe are the physical symptoms reported by these women compared to the symptoms reported by women with actual uterine fibroids? Are the symptoms more severe if the patient believes that she has at least one relatively large (dominant) fibroid or more than 3 fibroids? Material and Methods A total of 1548 patients completed an anonymous questionnaire in which they were asked about the number of their fibroids, dysmenorrhea and premenstrual symptoms, dyspareunia and bleeding disorders (using a numerical analog scale between 0 – 10). The questionnaire was administered in a hospital-based fibroid clinic. The information provided by the patients was then compared with transvaginal or abdominal ultrasound findings. The symptoms reported by women with and without fibroid(s) were compared. Results 1045 out of 1548 patients fulfilled the studyʼs inclusion criteria. Contrary to the information they provided, no fibroid(s) were detected in 6% (62 of 1045 patients) of patients on ultrasound examination. Of these women, 87% had dysmenorrhea, 79% had premenstrual pain and 57% reported dyspareunia. The severity of the symptoms was found not to be associated with the assumed size or number of fibroid(s). There was no significant difference in the pain reported by women without and by women with fibroids. Reporting a feeling of strong pressure on the bladder (OR: 1.18) or abdomen (OR: 1.12) or constipation (OR: 1.16) increased the likelihood of detecting a fibroid on ultrasound investigation. Conclusions The presence of manifest symptoms (dysmenorrhea, dyspareunia, premenstrual pain, bleeding disorders) does not allow conclusions to be made about the number or size of fibroids or about which therapy is indicated. Even an erroneous assumption about the presence of fibroids may result in patients experiencing symptoms.
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Yoon, Sang-Wook, Chan Lee, Kyoung Ah Kim, and Sang Heum Kim. "Contrast-Enhanced Dynamic MR Imaging of Uterine Fibroids as a Potential Predictor of Patient Eligibility for MR Guided Focused Ultrasound (MRgFUS) Treatment for Symptomatic Uterine Fibroids." Obstetrics and Gynecology International 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/834275.
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Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a non-invasive treatment approach for symptomatic uterine fibroids. One imaging characteristic considered in selecting patients who may benefit from MRgFUS of their uterine fibroids is the signal intensity of the fibroid compared with surrounding myometrium on T2-weighted MR images. Previous reports suggest that hyper-intense fibroids are less amenable to MRgFUS compared with iso- or hypo-intense fibroids. In this case study, we utilized contrast-enhanced dynamic MR imaging to further characterize the vascularity of a hyper-intense fibroid. Based on the results of dynamic T1-weighted contrast-enhanced images, we assumed that the hyper-intense appearance resulted from high fluid content rather than high vascularity and predicted that the fibroid would respond to MRgFUS. The patient underwent the MRgFUS without complication and reported significant decrease in fibroid symptoms at 3 and 12 months post-treatment. This case suggests that pre-treatment dynamic contrast-enhanced imaging used in conjunction with T2-weighted imaging may improve the criteria for selecting uterine fibroids amenable to treatment with MRgFUS, potentially leading to improved patient outcomes.
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Zaitseva, Marina, Sarah J. Holdsworth-Carson, Luke Waldrip, Julia Nevzorova, Luciano Martelotto, Beverley J. Vollenhoven, and Peter A. W. Rogers. "Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids." REPRODUCTION 146, no. 2 (August 2013): 91–102. http://dx.doi.org/10.1530/rep-13-0087.
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Uterine fibroids are the most common benign tumour afflicting women of reproductive age. Despite the large healthcare burden caused by fibroids, there is only limited understanding of the molecular mechanisms that drive fibroid pathophysiology. Although a large number of genes are differentially expressed in fibroids compared with myometrium, it is likely that most of these differences are a consequence of the fibroid presence and are not causal. The aim of this study was to investigate the expression and regulation of NR2F2 and CTNNB1 based on their potential causal role in uterine fibroid pathophysiology. We used real-time quantitative RT-PCR, western blotting and immunohistochemistry to describe the expression of NR2F2 and CTNNB1 in matched human uterine fibroid and myometrial tissues. Primary myometrial and fibroid smooth muscle cell cultures were treated with progesterone and/or retinoic acid (RA) and sonic hedgehog (SHH) conditioned media to investigate regulatory pathways for these proteins. We showed that NR2F2 and CTNNB1 are aberrantly expressed in fibroid tissue compared with matched myometrium, with strong blood vessel-specific localisation. Although the SHH pathway was shown to be active in myometrial and fibroid primary cultures, it did not regulateNR2F2orCTNNB1mRNA expression. However, progesterone and RA combined regulatedNR2F2mRNA, but notCTNNB1, in myometrial but not fibroid primary cultures. In conclusion, we demonstrate aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids compared with normal myometrium, consistent with the hypothesis that these factors may play a causal role uterine fibroid development.
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Tsiligiannis, S., M. Zaitseva, P. Coombs, P. Shekleton, B. Vollenhoven, M. Hickey, and P. Rogers. "302. FIBROID ASSOCIATED HEAVY MENSTRUAL BLEEDING: CORRELATION OF CLINICAL SYMPTOMS, DOPPLER ULTRASOUND ASSESSMENT OF VASCULATURE AND TISSUE GENE EXPRESSION PROFILES." Reproduction, Fertility and Development 22, no. 9 (2010): 102. http://dx.doi.org/10.1071/srb10abs302.
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Understanding of the mechanisms that cause fibroid associated heavy menstrual bleeding (HMB) is limited. Despite many fibroids having a highly vascular peri-fibroid myometrial (PFM) zone, angiogenic gene expression in this area has never been investigated. The aim of this study was to correlate clinical symptoms, ultrasound appearances and tissue gene expression profiles in women scheduled for hysterectomy due to symptomatic fibroids. We hypothesised that fibroid heterogeneity, colour flow and spectral Doppler resistive indices would correlate with differences in gene expression profiles. It was thought and that increased peri-fibroid gene expression of key angiogenic genes would correlate with increased peri-fibroid vascularity. N = 6 patients underwent B-mode, colour and spectral Doppler ultrasound assessment. Following hysterectomy tissue samples collected from three areas – fibroid, PFM and distant myometrium (DM) were analysed using quantitative RT-PCR and a customised angiogenesis PCR array. A higher mean peak systolic velocity (PSV) in the PFM region when compared to mean PSV within the fibroid (P < 0.001) was seen. Differences in angiogenic gene expression were consistent with the heterogeneity of the clinical data collected. One fibroid sample showed dissimilar gene expression to all other fibroids; at ultrasound and sample collection significant degenerative features were observed. Fibroid heterogeneity within a single uterus was also demonstrated, with two fibroids from the one uterus having significantly dissimilar gene profiles and ultrasound appearances. No differences in gene expression were found between PFM and DM. Despite this, gene interaction maps showed different interaction of genes between fibroid and PFM regions compared to genes between the fibroid and the DM. These are the first molecular data demonstrating that the PFM region may be functionally distinct from distant myometrium.
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Matsushima, Hisakazu, Ken Kageyama, Akira Yamamoto, Atsushi Jogo, Etsuji Sohgawa, Takehito Nota, Kazuki Murai, et al. "Observation of Intramural Fibroid Expulsion on MRI after Uterine Artery Embolization." Case Reports in Radiology 2021 (August 14, 2021): 1–5. http://dx.doi.org/10.1155/2021/7970894.
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Uterine artery embolization (UAE) is a type of noninvasive treatment for symptomatic uterine fibroids. One of the complications of UAE is fibroid expulsion. Here, we report a case of a 45-year-old woman who underwent UAE for an intramural fibroid, which resulted in fibroid expulsion. To the best of our knowledge, there are only few reports of expulsion of intramural fibroids. The process of fibroid protrusion from the myometrium into the uterine cavity was depicted on magnetic resonance imaging (MRI) in this case. We discuss the risk factors and mechanisms of fibroid expulsion after UAE.
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C., Amruta, Annappa Shetty, Naresh Pawaskar, and Shreya Desai. "Association between uterine leiomyoma with body mass index and parity in the women of coastal Karnataka, India." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 2 (January 28, 2020): 740. http://dx.doi.org/10.18203/2320-1770.ijrcog20200369.
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Background: Fibroid is the commonest benign tumor of the uterus and also commonest benign solid tumor in females. Fibroids are found to be 2-3 times more prevalent in obese women, specially the one’s with central obesity and in those with BMI > or = 35. Epidemiologic data also shows pregnancy is associated with reduced risk of fibroids. So, the present study will be a cross-sectional study which will be undertaken to know the association of uterine leiomyoma with BMI and parity in the women of coastal Karnataka.Methods: An analytical cross-sectional study was performed among the 100 patients attending OPD at the department of obstetrics and gynecology, Karwar institute of medical sciences from June 2018 to August 2018. Women suspected to have fibroid based on their symptoms were made to undergo ultrasonography. Comparison was made between the parity, body mass index of the patient and the size of the uterine fibroid visualized.Results: Out of 100 women studied 63 were nulliparous and 37 women were multiparous. Incidence of fibroid is inversely proportional to parity. When BMI < 18 only 6 women had fibroid, when BMI > 25, 57 women had fibroids and between 18-25 group 37 women were diagnosed with fibroid.Conclusions: The fibroid showed directly proportional association with BMI. Greater the BMI, more was the risk of fibroids. The fibroid showed inversely proportional association with parity. Greater the parity of the women lesser was her chances of being at risk of having fibroid.
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Gosline, J. M., P. A. Guerette, C. S. Ortlepp, and K. N. Savage. "The mechanical design of spider silks: from fibroin sequence to mechanical function." Journal of Experimental Biology 202, no. 23 (December 1, 1999): 3295–303. http://dx.doi.org/10.1242/jeb.202.23.3295.
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Spiders produce a variety of silks, and the cloning of genes for silk fibroins reveals a clear link between protein sequence and structure-property relationships. The fibroins produced in the spider's major ampullate (MA) gland, which forms the dragline and web frame, contain multiple repeats of motifs that include an 8–10 residue long poly-alanine block and a 24–35 residue long glycine-rich block. When fibroins are spun into fibres, the poly-alanine blocks form (β)-sheet crystals that crosslink the fibroins into a polymer network with great stiffness, strength and toughness. As illustrated by a comparison of MA silks from Araneus diadematus and Nephila clavipes, variation in fibroin sequence and properties between spider species provides the opportunity to investigate the design of these remarkable biomaterials.
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karlsen, kamilla, Ulrik Schiøler Kesmodel, Ole Mogensen, Peter Humaidan, and Pernille Ravn. "Relationship between a uterine fibroid diagnosis and the risk of adverse obstetrical outcomes: a cohort study." BMJ Open 10, no. 2 (February 2020): e032104. http://dx.doi.org/10.1136/bmjopen-2019-032104.
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ObjectiveThe aim was to investigate the association between clinically significant uterine fibroids and preterm birth, caesarean section (CS), postpartum haemorrhage (PPH), placental abruption, intrauterine growth restriction (IUGR) and uterine rupture.Methods, participants and settingA historical cohort study based on data from the Danish National Birth Cohort, the Danish National Patient Registry and the Danish National Birth Registry (DNBR). The final study population consisted of 92 696 pregnancies and was divided into four groups for comparison. Group 1: pregnancies of women without a fibroid diagnosis code or fibroid operation code; group 2: pregnancies of women with a fibroid diagnosis code before pregnancy, during pregnancy or up to 1 year after delivery, and no fibroid operation code before pregnancy; group 3: pregnancies of women with a fibroid diagnosis code given more than 1 year after delivery; and group 4: pregnancies of women with a fibroid operation code given before pregnancy.ResultsA diagnosis of fibroids before pregnancy yielded an increased risk of preterm birth (gestational age (GA) ≤37 weeks) (OR 2.27 (1.30─3.96)) and extreme preterm birth (GA 22+0─27+6 weeks, OR 20.09 (8.04─50.22)). The risk of CS was increased (OR 1.83 (1.23─2.72)) for women with a fibroid diagnosis code given before pregnancy; significantly increased risk of elective CS (OR 1.92 (1.11─3.32)), but not acute CS (OR 1.54 (0.94─2.52)). The risks of PPH, placental abruption or IUGR were not increased in any of the groups.ConclusionWe found a strong association between clinically significant uterine fibroids and preterm birth, and an association between clinically significant uterine fibroids and CS. In contrast, no association between clinically significant uterine fibroids and PPH, placental abruption or IUGR was seen.
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Ng, Sinnie Sin Man, Soledad Jorge, Minnie Malik, Joy Britten, Szu-Chi Su, Charles R. Armstrong, Joshua T. Brennan, et al. "A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells." Journal of Clinical Endocrinology & Metabolism 104, no. 3 (September 14, 2018): 970–80. http://dx.doi.org/10.1210/jc.2018-01216.
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Abstract Context Uterine leiomyomata (fibroids) are prevalent sex hormone‒dependent tumors with an altered response to mechanical stress. Ulipristal acetate, a selective progesterone receptor (PR) modulator, significantly reduces fibroid size in patients. However, PR signaling in fibroids and its relationship to mechanical signaling are incompletely understood. Objective Our prior studies revealed that A-kinase anchoring protein 13 (AKAP13) was overexpressed in fibroids and contributed to altered mechanotransduction in fibroids. Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids. Methods and Results Fibroid samples from patients treated with ulipristal acetate or placebo were examined for AKAP13 expression by using immunohistochemistry. In immortalized uterine fibroid cell lines and COS-7 cells, we observed that AKAP13 increased ligand-dependent PR activation of luciferase reporters and endogenous progesterone-responsive genes for PR-B but not PR-A. Inhibition of ERK reduced activation of PR-dependent signaling by AKAP13, but inhibition of p38 MAPK had no effect. In addition, glutathione S-transferase‒binding assays revealed that AKAP13 was bound to PR-B through its carboxyl terminus. Conclusion These data suggest an intersection of mechanical signaling and PR signaling involving AKAP13 through ERK. Further elucidation of the integration of mechanical and hormonal signaling pathways in fibroids may provide insight into fibroid development and suggest new therapeutic strategies for treatment.
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Alhainiah, Maha, Elaf Aljifry, Ayman Alghamdi, Lujain Alrabghi, Abdullah Alharbi, Ezdehar Alrowaithi, Fatimah Almuallem, Elaf Fakeih, Bassmah Alrowaithi, and Hassan Allam. "Safety of pregnancy in uterine fibroids." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 8 (July 26, 2018): 2985. http://dx.doi.org/10.18203/2320-1770.ijrcog20182924.
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Uterine fibroid is one of the most common intrauterine masses among females at the reproductive age. Pregnancy and uterine fibroids are highly correlated. Pregnancy-related hormones influence the size of uterine fibroids, and fibroids have many impacts on pregnancy. Although most if the uterine fibroids are asymptomatic during pregnancy, serious complications may occur. The main complications include abortion, premature rupture of membranes, premature labor, abruptio placentae, peripartum hemorrhage, fetal malpresentation, fetal intrauterine growth retardation, small for gestational age infants, and fetal anomalies. The main risk factors for complications are related to the fibroid number, size, volume, location, and type. Large, multiple, retroplacental, submucosal, subserosal, pedunculated, or low-lying fibroids carries the highest risk for complications during pregnancy. This review will address the prevalence of uterine fibroids during pregnancy, its effects, and complications.
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Varvaki Rados, Pantelis. "Discriminação Histológica entre Displasia Fibrosa Monostótica, Fibroma Ossificante e Fibroma Cementificante." Revista da Faculdade de Odontologia de Porto Alegre 29, no. 28/29 (April 22, 1989): 48–59. http://dx.doi.org/10.22456/2177-0018.102203.
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Foi realizado um estudo histométrico comparativo entre Displasia Fibrosa, Fibroma Ossificante e Fi- broma Cementificante, com base em seis casos para cada lesão, os quais tinham diagnósticos clínicos, radio- gráficos e histológicos confirmados. O objetivo principal era estabelecer diferenças que permitissem realizar de forma objetiva o diagnóstico histológico. Para isso foram analisadas variáveis relacionadas corri o tecido conjuntivo fibroso e o tecido mineralizado; foram estabelecidos índices considerando as relações entre alguns dos parâmetros analisados. Se pode observar na Fibroma Ossificante, que as células do tecido conjuntivo fibroso tem uma tendência a transformar-se em célula geradoras de matriz orgânica mineralizada. A Displasia Fibrosa demonstrou uma marcada relação entre a presença de vasos sangüíneos e zonas de hemorragia, além de ser com- provada a presença de osteoblastos rodeando as trabéculas mineraliza- das, o que é negado por alguns autores para esta lesão. O fibroma Cementificante apresenta matriz orgânica não mineralizada com uma área maior que na Displasia Fibrosa e no Fibroma Ossificante, possivelmente por ter uma mineralização mais lenta. Apresentou também uma menor quantidade de células em seu interior. A variável mais confiável para diferenciar as três lesões entre si, é a forma das trabéculas, predominando os "cementículos" no Fibroma Cementificante, "caracteres chineses" na Displasia Fibrosa e as trabéculas retangulares no Fibroma Ossificante
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Moore, Kristen, and Donna Baird. "Genital Chlamydia trachomatis Seroprevalence and Uterine Fibroid Development: Cohort Study of Young African-American Women." Microorganisms 10, no. 1 (December 22, 2021): 10. http://dx.doi.org/10.3390/microorganisms10010010.
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Few studies have investigated the 1930s hypothesis that reproductive tract infections are risk factors for fibroid development. In our 2017 cross-sectional analysis from the Study of Environment, Lifestyle, and Fibroids (2010–2018), a large Detroit community-based cohort of 23–35 year-old African-American women with ultrasound fibroid screening, we found an inverse association between seropositivity for genital Chlamydia trachomatis (gCT) infection and fibroids. With prospective data from the cohort (standardized ultrasounds every 20 months over 5 years), we examined gCT’s associations with fibroid incidence (among 1158 women fibroid-free at baseline) and growth. We computed adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incidence by gCT serostatus using Cox proportional hazards models. GCT’s influence on growth was assessed by estimating the difference between fibroid size change for seropositive vs. seronegative between successive ultrasounds (1254 growth measures) using a linear mixed model. Growth was scaled to change over 18 months. GCT seropositivity was not associated with fibroid incidence (aHR, 1.0 95% CI: 0.79, 1.29) or growth (4.4%, 95% CI: −5.02, 14.64). The current evidence based on both biomarker gCT data, which can capture the common undiagnosed infections, and prospective ultrasound data for fibroids suggests that Chlamydia is unlikely to increase fibroid risk.
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Holdsworth-Carson, Sarah J., Marina Zaitseva, Jane E. Girling, Beverley J. Vollenhoven, and Peter A. W. Rogers. "Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium." REPRODUCTION 147, no. 5 (May 2014): 683–92. http://dx.doi.org/10.1530/rep-13-0580.
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Uterine fibroids are a prevalent gynaecological condition in reproductive-aged women and are the commonest reason for hysterectomy. The cellular composition of clonal fibroids are heterogeneous, with phenotypically dissimilar cells that include smooth muscle cells (SMC), vascular SMC (VSMC) and fibroblasts. The aim of our study was to investigate genes that are commonly differentially expressed between fibroid and myometrial whole tissues in phenotypically different sub-populations of cells isolated from fibroid and myometrium. Genes to be investigated by fluorescence-activated cell sorting, quantitative real-time PCR and immunocytochemistry include transforming growth factor β (TGFB) and retinoic acid (RA) signalling families and steroid hormone receptors. We hypothesised that each cell population isolated from fibroid and myometrium would differ in the expression of fibroid-associated genes. We demonstrated that phenotypically different cellular constituents of uterine fibroids differentially express cellular RA-binding protein 2 (CRABP2), progesterone receptor B (PRB) and TGFB receptor 2 mRNA in fibroid-derived cells of VSMC and SMC phenotype. CRABP2 mRNA was also differentially expressed in fibroblasts and VSMC sub-populations from within clonal fibroid tumours. We conclude that differential regulation of RA, TGFB and PR pathway transcription occurs in fibroid-associated SMC and -fibroblasts and that investigation of paracrine interactions between different cell types within the fibroid microenvironment provides an important new paradigm for understanding the pathophysiology of this common disease.
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Miguel, Márcia Cristina da Costa, Emanuel Savio de Souza Andrade, Danielle Albuquerque Pires Rocha, Roseana de Almeida Freitas, and Lélia Batista de Souza. "Expressão imuno-histoquímica da vimentina e do HHF-35 em fibroma de células gigantes, hiperplasia fibrosa e fibroma da mucosa oral." Journal of Applied Oral Science 11, no. 1 (March 2003): 77–82. http://dx.doi.org/10.1590/s1678-77572003000100013.
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O fibroma de células gigantes, a hiperplasia fibrosa e o fibroma constituem algumas das mais freqüentes lesões fibrosas orais, compartilhando características clínicas e histopatológicas. Este estudo teve o objetivo de investigar a imunorreatividade das células gigantes estreladas mono, bi ou multinucleadas, características do fibroma de células gigantes e, ocasionalmente presentes na hiperplasia fibrosa e no fibroma, a anticorpos anti-vimentina e anti-actina de músculo (HHF-35), visando detectar características fenotípicas destas células. Os resultados demonstraram que na maioria dos casos houve imunorreatividade para a vimentina, sugerindo um fenótipo fibroblástico para estas células.
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Keizer, A. L., L. L. Niewenhuis, W. J. K. Hehenkamp, J. W. R. Twisk, H. A. M. Brölmann, and J. A. F. Huirne. "Fibroid vascularisation assessed with 3D Power Doppler as predictor for fibroid related symptoms and quality of life; a pilot study." Facts, Views and Vision in ObGyn 13, no. 4 (December 2021): 387–94. http://dx.doi.org/10.52054/fvvo.13.4.044.
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Background: Uterine fibroids present differently, from well vascularised up to calcified, with some causing heavy menstrual bleeding (HMB). Objectives: To investigate the association between fibroid vascularisation and HMB, other fibroid related symptoms and quality of life (QOL). Materials and Methods: A single centre pilot study was carried out in the Netherlands. Women with a maximum of two fibroids who chose expectant management were included. 3D sonography including power doppler was performed at baseline and at 3, 6 and 12 months follow up. Women were asked to complete the Pictorial Blood Assessment Chart (PBAC) and Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaires at every visit. Main outcome measure: The association between fibroid vascularisation and HMB. Results: 53 women were included in the study. Baseline fibroid vascularisation, measured as vascular index (VI) is associated with PBAC score; a 1% higher VI at baseline leads to an 11 point increase in PBAC score over time (RC 10.99, p=0.05, 95% CI -0.15 – 22.12). After correction for the baseline variables ethnicity and fibroid type the association becomes stronger (P<0.05). Fibroid volume at baseline and HMB are also associated: a 1 cm3 larger fibroid leads to 0.6 points increase in PBAC score over time (RC 0.56, p=0.03, 95% CI 0.05 – 1.07). Conclusions: This study highlights that both fibroid vascularisation and fibroid volume may be associated with an increase in menstrual blood loss, other fibroid related symptoms and QOL over time. What is new? We used 3D power doppler to predict symptomatic fibroids.
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Mahendru, Rajiv, Geetinder Gaba, Shweta Yadav, Gurmeet Gaba, and Chinky Gupta. "A Rare Case of Retroperitoneal Leiomyoma." Case Reports in Surgery 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/425280.
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Introduction. Leiomyoma uteri is one of the most common benign conditions for which women undergo hysterectomy every year. Fibroids found retroperitoneally are a rare entity, especially, primary retroperitoneal fibroid.Case Presentation. We report a case of 42-year-old para 1 who presented to our hospital with recurring retention of urine, lower abdominal and pelvic pain, and dyspareunia . Provisional diagnosis on the basis of examination and imaging was large subserosal fibroid with mild right-sided hydroureteronephrosis, due to pressure effect of the fibroid. Abdominal hysterectomy was done for the patient, and intraoperatively, a bulky uterus was found with multiple small fibroids on anterior and posterior walls, and a large fibroid approx.10×8 cm was found arising from the posterior surface at the level of internal os retroperitoneally, which was confirmed by histopathology as leiomyoma.Conclusion. Retroperitoneal fibroids are rare neoplasms and treatment is surgical removal. Preoperative imaging can only give provisional diagnosis and can be misguiding. Final diagnosis of retroperitoneal fibroid can be made only intraoperatively.
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Zota, Ami R., Ruth J. Geller, Brianna N. VanNoy, Cherie Q. Marfori, Sana Tabbara, Lisa Y. Hu, Andrea A. Baccarelli, and Gaby N. Moawad. "Phthalate Exposures and MicroRNA Expression in Uterine Fibroids: The FORGE Study." Epigenetics Insights 13 (January 2020): 251686572090405. http://dx.doi.org/10.1177/2516865720904057.
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Phthalates are associated with multiple, adverse reproductive outcomes including increased risk of uterine leiomyoma (fibroids). Phthalates can interact with epigenetic modifications including microRNAs (miRNAs), which help regulate processes crucial to fibroid pathogenesis. However, no prior study has examined the influence of phthalates on miRNA expression in fibroid tumors. We conducted a preliminary, cross-sectional study to examine the associations between phthalate exposures and miRNA expression levels in fibroid tumors and to explore potential effect modification by race/ethnicity. We quantified expression levels of 754 miRNAs in fibroid tumor samples and analyzed spot urine samples for phthalate metabolites collected from 45 pre-menopausal women undergoing surgery for fibroid treatment at an academic hospital. Associations between miRNA levels in fibroids and phthalate biomarkers were evaluated using linear regression adjusting for age, race/ethnicity, and body mass index (BMI). Statistical tests were adjusted for multiple comparisons. We also performed in silico Ingenuity Pathway Analysis to identify the biological pathways that are regulated by phthalate-associated miRNAs. Mono-hydroxybutyl phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate were positively associated with miR-10a-5p (β = 0.76, 95% CI = [0.40, 1.11]) and miR-577 (β = 1.06, 95% CI = [0.53, 1.59]), respectively. A total of 8 phthalate-miRNA associations varied by race/ethnicity (qinteraction < 0.10). Pathway analysis revealed that mRNA gene targets of phthalate-associated miRNAs were significantly associated with multiple fibroid-related processes including angiogenesis, apoptosis, and proliferation of connective tissues. Collectively, these data suggest that exposures to some phthalates are associated with miRNA in fibroids, and that associations may vary by race/ethnicity. Validation of these findings may provide insight into mechanisms underlying associations between phthalates and fibroids and contribute to novel hypotheses regarding racial/ethnic disparities in fibroids.
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Jamaluddin, M. Fairuz B., Yi-An Ko, Manish Kumar, Yazmin Brown, Preety Bajwa, Prathima B. Nagendra, David A. Skerrett-Byrne, et al. "Proteomic Profiling of Human Uterine Fibroids Reveals Upregulation of the Extracellular Matrix Protein Periostin." Endocrinology 159, no. 2 (December 13, 2017): 1106–18. http://dx.doi.org/10.1210/en.2017-03018.
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Abstract The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies, which relate to MED12. We performed extensive genetic and proteomic analyses of clinically annotated fibroids and adjacent normal myometrium to identify the composition and expression patterns of ECM proteins in MED12 mutation–positive and mutation–negative uterine fibroids. Genetic sequencing of tissue samples revealed MED12 alterations in 39 of 65 fibroids (60%) from 14 patients. Using isobaric tagged–based quantitative mass spectrometry on three selected patients (n = 9 fibroids), we observed a common set of upregulated (>1.5-fold) and downregulated (<0.66-fold) proteins in small, medium, and large fibroid samples of annotated MED12 status. These two sets of upregulated and downregulated proteins were the same in all patients, regardless of variations in fibroid size and MED12 status. We then focused on one of the significant upregulated ECM proteins and confirmed the differential expression of periostin using western blotting and immunohistochemical analysis. Our study defined the proteome of uterine fibroids and identified that increased ECM protein expression, in particular periostin, is a hallmark of uterine fibroids regardless of MED12 mutation status. This study sets the foundation for further investigations to analyze the mechanisms regulating ECM overexpression and the functional role of upregulated ECM proteins in leiomyogenesis.
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Mendiratta, Sumanlata, Soumya Dash, Rajni Mittal, Suman Dath, Manisha Sharma, and Rajiv N. Sahai. "Cervical fibroid: an uncommon presentation." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 9 (August 28, 2017): 4161. http://dx.doi.org/10.18203/2320-1770.ijrcog20174084.
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Fibroids arising from cervix are rare tumours accounting for 2% of all fibroids. A cervical leiomyoma is commonly single and is either interstitial or subserous, rarely it becomes submucous and polypoidal. Anterior cervical fibroid may press on urinary bladder and urethra and displace the urethro-vesical junction giving rise to urinary frequency and retention. Management of symptomatic cervical fibroid is hysterectomy or myomectomy and need an expert hand. Here we report a case of huge anterior cervical fibroid of 15x15x7cm with an unusual presentation of menorrhagia of only 2 days and no urinary symptoms. Inspite of the fibroid being huge and impacted, hysterectomy was done successfully without any injury to bladder and ureters.
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Wang, Ya, Pei Li, Chen Hui Zhu, and Dai Di Fan. "A Novel Hydrophobic-Induced Method for Water Soluble Silk Fibroin." Advanced Materials Research 535-537 (June 2012): 1991–96. http://dx.doi.org/10.4028/www.scientific.net/amr.535-537.1991.
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A new hydrophobic method of regenerated silk fibroin was introduced here, in which glycerol was used as the inducer. As a consequence, the soluble form of silk was transformed into hydrophobic form, which hence suggests glycerol has a significant effect of hydrophobic induction. Then the morphology and mechanical properties of the hydrophobic silk fibroin was respectively shown by scanning electron microscope (SEM) and strain test. The results showed induced silk fibroin had a compact surface and good mechanical property. Finally, the induction mechanism of glycerol was discussed that glycerol could soften the fibroin’s structure during dry process ,which was the main reason leading to β-sheets of fibroin partly being rebuilt and then the hydrophobic transformation being achieved.
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Ryann Louie, Allison, Jennifer Alice Armstrong, Laura Katherine Findeiss, and Scott Craig Goodwin. "Comparison of Sexual Dysfunction Using the Female Sexual Function Index following Surgical Treatments for Uterine Fibroids." Case Reports in Obstetrics and Gynecology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/368136.
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Uterine fibroids are a common problem in women. Statistics showing 20–50% of fibroids produce symptoms and consequently patients seek surgical intervention to improve their quality of life. Treatments for fibroids are typically successful in controlling the fibroid disease, yet sexual function following invasive surgical treatments for fibroids can be jeopardized. The Sexual Function Index (FSFI) is a valid instrument producing quantifiable reproducible results. In this paper three case reports are evaluated by the FSFI and compared between the following treatment groups: hysterectomy, myomectomy, and uterine embolization. Our goal is to illustrate how each of these treatment outcomes can result in sexual dysfunction and therefore decreased quality of life. Effects of invasive fibroid treatments on sexual functioning would be helpful in guiding patient’s ultimate decisions regarding treatment.
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Khotanlou, Hassan, Alireza Fallahi, Mohammad Ali Oghabian, and Mohammad Pooyan. "SEGMENTATION OF UTERINE FIBROID ON MR IMAGES BASED ON CHAN–VESE LEVEL SET METHOD AND SHAPE PRIOR MODEL." Biomedical Engineering: Applications, Basis and Communications 26, no. 02 (March 12, 2014): 1450030. http://dx.doi.org/10.4015/s1016237214500306.
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Uterine fibroids are common tumors of female pelvis. Uterine artery embolization (UAE) is an effective treatment of symptomatic uterine fibroids by shrinkage of the size of these tumors. Segmentation of the fibroid region is essential for an accurate treatment strategy. Complex fibroids anatomy, nonhomogeneity region and missing boundary in some cases make this task very challenging. In this paper, we present a method to robustly segment these fibroids on magnetic resonance image (MRI). Our method is based on combination of two steps; Chan–Vese level set method and geometric shape prior model. By calculating an initial region inside the fibroid using Chan–Vese level sets method, rough segmentation can be obtained followed by a prior shape model. We found this algorithm efficient, which provides good and reliable result.
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Geetha, A. Mangala. "Lantern on Saint Paul’s dome - A case report of cervical fibroid." Indian Journal of Obstetrics and Gynecology Research 8, no. 1 (March 15, 2021): 110–12. http://dx.doi.org/10.18231/j.ijogr.2021.023.
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Leiomyoma are the commonest benign tumors affecting the female reproductive tract and constitute to around 18-20% of the uterine pathologies that are seen in women of the reproductive age group. Depending on its location in the uterus, fibroids are classified as uterine, cervical and ligamentary of which the cervical fibroids are the rarest and make up only around 2-2.5% of the total incidence of fibroids. Large cervical fibroids give a typical appearance known as “Lantern on St. Paul’s dome” where the small sized normal uterus sits on top of the cervical fibroid mimicking the Lantern on the dome of famous St. Paul’s Cathedral of Russia. This is a report of a case of cervical fibroid which showed the typical appearance and was successfully operated with no organ damage or blood loss.
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Dubey, Sunita, Poonam Goel, Nidhi Pandey, and Pavithra H. N. "Pseudo-Meigs syndrome: a rare presentation of pedunculated fibroid." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 7 (June 25, 2020): 3052. http://dx.doi.org/10.18203/2320-1770.ijrcog20202756.
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Serosal fibroid of uterus are usually asymptomatic but rarely; it may present with atypical symptoms to simulate malignancy and needs extensive evaluation. Authors are reporting a case of 26 years old P1L1 female with history of asymptomatic multiple intramural fibroids since 6 years came with complained of progressively increasing abdominal distension and mild pain abdomen from 2-3 months. On evaluation, she had ascites, pleural effusion and raised Ca-125. MR imaging of pelvis revealed moderate ascites and pedunculated serosal fibroid in addition to intramural fibroids with normal bilateral ovaries. She was evaluated to rule out uterine sarcoma and tuberculosis but diagnosis of them could not be established. Finally, conclusion of Pseudo-Meigs syndrome was made. Myomectomy of single pedunculated fibroid relieved her symptoms. Though, subserosal fibroids are benign in pathology, timely surgery is must to avoid morbidity and mortality owing to massive ascites and pleural effusion.
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Costa, Ana R., Ana P. Carvalho, Diana R. Martins, Maria J. Carvalho, Pedro T. Silva, Sílvia C. Roque, and Daniel P. Silva. "Series of 55 pregnancies following ulipristal acetate treatment of symptomatic uterine fibroids." Journal of Endometriosis and Pelvic Pain Disorders 12, no. 3-4 (July 20, 2020): 170–75. http://dx.doi.org/10.1177/2284026520932468.
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Introduction: Treatment with ulipristal acetate effectively controls excessive bleeding due to uterine fibroids and reduces their size. Uterine fibroid size reduction is expected to improve the results of the myomectomy and the reproductive prospects of the patient. Methods: Retrospective and descriptive analysis of a series of 53 patients who achieved pregnancy after being treated for symptomatic uterine fibroids. The primary endpoints were pregnancy and birth outcomes in women with symptomatic uterine fibroids that conceived following at least one course of therapy with ulipristal acetate 5 mg/day. The secondary endpoints were time until pregnancy, reasons for ulipristal acetate treatment, number of treatment courses completed, hemorrhagic control achievement, hemoglobin levels, fibroid FIGO classification, largest fibroid diameter, and type of myomectomy (if any). Results: Fifty-five pregnancies were registered in 53 patients following ulipristal acetate therapy (43 live births, 9 miscarriages, and 3 ongoing pregnancies). Half of the patients became pregnant without interval surgery. Bleeding control was achieved in 96% of the cases. A significant increase (p < 0.001) in hemoglobin levels and a reduction (p < 0.001) in uterine fibroid size was observed after treatment. No malformations were reported among newborns after ulipristal acetate therapy. Conclusion: So far, this is the largest case series reporting both pregnancy and birth outcomes following ulipristal acetate therapy for uterine fibroids. Our data support favorable outcomes after therapy for this population subset.
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Olapade*, Ebenezer Oluwafemi, Ebenezer Oluwafemi Olapade, Clement Akinlayo Oluwadayomi Olapade, Christiana Oluwabusayo Olapade, and John Babajide Olapade. "Recent Successes in the Use of Natural Herbal Remedies for the Treatment of Intra-uterine Fibroids Without Surgery." HortScience 39, no. 4 (July 2004): 860E—861. http://dx.doi.org/10.21273/hortsci.39.4.860e.
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Many physiologically active women after reaching the age of puberty suddenly discover that their menstruation becomes irregular with longer periods of heavier flow. This situation often arise when the womb is empty without conception for a long time. The uterus is found to contain some growing masses of tissues called fibroid which may be tiny, single, many or very big. They could occupy the lumen of the uterus and referred to as intra-uterine fibroids or could develop within the walls of the uterus or on the outside wall of the uterus. They alter the shape and size of the uterus in most cases. Intra-uterine fibroids grow in size and in several cases prevent conception in young women who are eager to get pregnant, thereby leading to frustration, and anxiety. The origin and cause of fibroids is not well understood. Ethno medicinal knowledge refer to fibroids as false pregnancy because women carrying fibroids are thought to be pregnant for several years without delivering the baby. Years of ethno medicinal research at the NARL Specialist Clinic, Ibadan, Nigeria led to the compounding of natural plants which include Calotropis sp, Citrus sp and a few tropical plants that have proved successful as a remedy for intra-uterine fibroids without surgery. The existing fibroid masses within the uterus gradually diminish in size, until they disappear completely The re-growth of fibroid masses within the uterus is suppressed or inhibited This will be helpful in many cases where women who have not reached menopause can have free uterine cavity devoid of fibroids especially when they are not pregnant for several years. The problem of infertility due to fibroids can also be avoided.
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Kgomo, Hlobsile, Somandla Ncube, Vimbai Mhuka, Temesgen Girma Kebede, Simiso Dube, and Mathew M. Nindi. "A Comparative Study on the Dissolution of Argema mimosae Silk Fibroin and Fabrication of Films and Nanofibers." Polymers 13, no. 4 (February 12, 2021): 549. http://dx.doi.org/10.3390/polym13040549.
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Limited studies have been done on silk fibroins of wild silkworm species owing to their relative insolubility in many solvents. In this study, the solubility of Argema mimosae wild silk fibroin in different salts (LiBr, LiCl, Ca(NO3)2, and CaCl2) dissolved in formic acid under varying temperatures was investigated. The dissolution conditions under which the solubility was optimum were optimized using a central composite design approach. The optimum range for solvation of the fibroin were visualized using contour plots. The influence of temperature and salt concentration were found to significantly influence the solvation of the fibroin. Following the successful dissolution of the fibroin, the regenerated silk fibroin solutions were cast to obtain water insoluble films which were used in investigating optimum electrospinning conditions. Average nanofiber diameters in the 110–141 nm range were obtained under optimum electrospinning conditions. The silk forms were characterized using the FTIR, TGA, XRD, and SEM to understand their properties. The investigations revealed that formic acid—salt solvents were effective in the solvation of the wild silk fibroin. Some of the dissolution conditions induced mild effects on the silk fibroin while others were harsh. Furthermore, processing to nanofibers resulted in the degradation of the β-sheets producing nanofibers rich in α-helices. However, post-treatment using methanol and water vapor were effective in restoring β-sheet crystallinity.
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Abdelmtalab, Mohammed A. A., O. Tahir, K. Hussein, and Kamal Badawi. "Anatomical locations of uterine fibroids in Sudanese women." Anatomy Journal of Africa 9, no. 1 (April 5, 2020): 1701–6. http://dx.doi.org/10.4314/aja.v9i1.6.
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Uterine fibroids are the commonest uterine neoplasms, they are benign tumors of smooth muscle origin. The study was done to look for the anatomical locations of uterine fibroids and their incidence in Sudanese women at Omdurman Maternity Hospital between 1st July 2014 to 5th October 2015. Their sociodemographic and ultrasound data were collected using a prepared questionnaire. The study included 138 confirmed cases of uterine fibroids out of 2968 investigated cases representing incidence rate of 4.6%. The highest incidence was found in the age group 36-40 years. Most dominant anatomical locations of uterine fibroids were intramural as a single mass (34.78%), followed by the intramural-subserosal in multiple masses (20.29%). The anatomical positions of uterine fibroids, posterior position was seen in (27.5%) which was the most dominant in single uterine fibroid mass, followed by the anterior-posterior position in multiple uterine one (18.1%). Intramural anatomical locations in single mass are the commonest uterine fibroids types which affect the Sudanese women.
Key words: Anatomical locations; Uterine fibroid and leiomyomas
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Rawat, Rajneesh, Manik Gedam, Jyoti Baghel, and Shalini Baghel. "A rare association of uterine leiomyoma with mesenteric vein thrombosis and bowel gangrene: case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 4 (March 24, 2021): 1721. http://dx.doi.org/10.18203/2320-1770.ijrcog20211167.
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Uterine fibroids are the most common benign pelvic tumors in women. There are many complications reported with fibroids. However, mesenteric vein thrombosis and small bowel gangrene caused by a uterine fibroid are rare. This manuscript reports a rare case of 40 year female with a large uterine fibroid associated with mesenteric vein thrombosis and bowel ischemia. She underwent exploratory laparotomy in which resection of gangrenous bowel including jejunum and ileum was done along with left sided jejunostomy and right sided ileostomy. Total abdominal hysterectomy with bilateral salpingooophorectomy was done followed by jejunoileal anastomosis 6 weeks later. Hence, in patients presenting with acute abdomen and uterine fibroids, bowel gangrene must be included in the differential diagnosis.
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Kirschen, Gregory W., Abdelrahman AlAshqar, Mariko Miyashita-Ishiwata, Lauren Reschke, Malak El Sabeh, and Mostafa A. Borahay. "Vascular biology of uterine fibroids: connecting fibroids and vascular disorders." Reproduction 162, no. 2 (August 1, 2021): R1—R18. http://dx.doi.org/10.1530/rep-21-0087.
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Fibroids are benign tumors caused by the proliferation of myometrial smooth muscle cells in the uterus that can lead to symptoms such as abdominal pain, constipation, urinary retention, and infertility. While traditionally thought of as a disease process intrinsic to the uterus, accumulating evidence suggests that fibroid growth may be linked with the systemic vasculature system, although cell-intrinsic factors are certainly of principal importance in their inception. Fibroids are associated with essential hypertension and preeclampsia, as well as atherosclerosis, for reasons that are becoming increasingly elucidated. Factors such as the renin–angiotensin–aldosterone system, estrogen, and endothelial dysfunction all likely play a role in fibroid pathogenesis. In this review, we lay out a framework for reconceptualizing fibroids as a systemic vascular disorder, and discuss how pharmaceutical agents and other interventions targeting the vasculature may aid in the novel treatment of fibroids.
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Xess, Somila, and Jaiprakash Sahu. "A study to correlate association between vitamin D with fibroid and its supplementation in the progression of the disease." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 4 (March 25, 2020): 1477. http://dx.doi.org/10.18203/2320-1770.ijrcog20201208.
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Background: Uterine fibroids, or leiomyomas are the most common benign tumors of the female reproductive tract, affecting up to 60% of Indian women with only 25% of women who are symptomatic. Symptoms do not always correlate with the size, number, or location of the fibroids. Recent studies suggest that hypovitaminosis D is associated with an increased risk of uterine fibroids.Methods: Total 110 women diagnosed with fibroid in USG were included in the study. Inclusion and exclusion criteria were applied and size of the fibroid noted. 60 women were included in the study group who took Vitamin D supplementation and 50 women in the control group who didn’t perform the study properly.Results: The growth pattern of fibroids with study group under supplementation with 25-OH-D3 seems to be stable, with no increases or decreases in size or number of identified lesions. Instead, women in control group, who did not perform appropriate vitamin D supplementation seem to have a slight but significant increase in size of the lesions.Conclusions: It was seen that hypovitaminosis D was associated with fibroid and thus supplementation with Vitamin D helped in the shrinkage of fibroid or slower the progression of the disease.
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Shamim, Shayela, and A. Rouf. "Successful Return of Regular Menstrual Flow After Removal of A Huge Cervical Fibroid: A Case Report." Journal of Surgical Sciences 17, no. 1 (October 27, 2019): 58–61. http://dx.doi.org/10.3329/jss.v17i1.43713.
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Fibroids are the commonest benign neoplasm of the uterus and have long been implicated as a cause of complication during pregnancy and delivery. Fibroids arising from uterine cervix constitute only less than 2% of all fibroids and a very large cervical fibroid is even rarer1·2·3. This is case report of pregnancy with a huge cervical fibroid that necessitated caesarean section delivery. This unusually large fibroid (20 x 17 x 16 cm) was grown from the cervix that pushed up the uterine body upward. During initial caesarean operation the surgical team could not ascertain about the origin of the mass and closed the abdomen without remony the man. Subsequent laparotomy three months after caesarean section finally confirmed the diagnosis of the huge cervical fibroid. It was dissected out from the surrounding adhesion followed by end-to-end anastomosis of the gap between uterus and cervix. The postoperative period was uneventful with smooth recovery. The patient was followed up couple of times after discharge and reported to be well with return of her normal menstrual and reproductive function.
Journal of Surgical Sciences (2013) Vol. 17 (1) : 58-61
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Juneja, Sunil Kumar, Gagandeep Kaur, and Muskan Chaudhary. "Management of single submucosal fibroid in unmarried females with uterine artery embolization." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 2 (January 28, 2020): 774. http://dx.doi.org/10.18203/2320-1770.ijrcog20200375.
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Background: Uterine fibroids (leiomyomas) are the most common benign neoplasm of the female pelvis. The location of fibroids, whether submucosal, subserosal, pedunculated subserosal, intramural, or endocavitary, is important because signs and symptoms may be determined by location. Uterine artery embolization (UAE) for many patients is an effective alternative treatment to surgical therapy for fibroid tumors. It is a minimally invasive procedure, which allows for rapid recovery and return to normal activities. Objective of this study was to know the efficacy of minimally invasive technique UAE for reducing symptoms in sub-mucous uterine leiomyoma in unmarried females.Methods: This retrospective analysis was performed on 9 unmarried females with symptomatic single submucosal fibroid diagnosed on MRI with size range of 3.5 cms to 6.5 cms. They presented at Dayanand Medical College and Hospital, Ludhiana, Punjab in a period of 3 years from January 2016-December 2019. Inclusion criteria were unmarried females, single submucosal fibroid diagnosed on USG/MRI. Exclusion criteria was active infection, more than one fibroid in uterus, prior GnRH analogues treatment during the previous 3 months.Results: All patients presented with heavy menstrual bleeding (HMB) and dysmenorrhea, lower abdomen pain was encountered in 3 patients and 2 patients had inter-menstrual bleeding. Recurrent, UTI was there in 1 patient and 1 patient had vaginal discharge. All fibroids belonged to stage 1 FIGO classification. UAE was done and patients were followed for 6 months. Symptomatic success was seen in 100% patients and 77.77% patients expelled the fibroid per vaginally.Conclusions: UAE is alternative method of treatment for submucosal fibroids in unmarried females who do not want to undergo surgery. Proper case selection can give us good results and symptomatic relief.
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Alves, Adriana L., Canavarros Fernando, Daniela S. A. Vilela, Lídio Granato, and José D. Próspero. "Displasia fibrosa: relato de três casos." Revista Brasileira de Otorrinolaringologia 68, no. 2 (March 2002): 288–92. http://dx.doi.org/10.1590/s0034-72992002000200022.
Full textAbstract:
A displasia fibrosa é lesão pseudo-neoplásica de etiologia desconhecida, caráter benigno e recidivante, caracterizada pelo desenvolvimento de tecido fibroso e traves osteóides que substituem gradualmente o osso normal. O principal diagnóstico diferencial da forma monostótica, no envolvimento dos ossos da cabeça e pescoço, é o fibroma ossificante, que alguns consideram variante desta entidade. Esse trabalho tem como objetivo revisar as principais características clínicas, radiológicas e histopatológicas que auxiliam no diagnóstico diferencial da displasia fibrosa com o fibroma ossificante e discutir o comportamento recidivante da displasia fibrosa, essencial ao planejamento cirúrgico. Relatamos três casos provenientes do ambulatório de Otorrinolaringologia da Santa Casa de Misericórdia de São Paulo, avaliados quanto às queixas, exame físico, achados de imagem e tratamentos. Nos três casos o diagnóstico foi confirmado pelo exame anatomopatológico. Todos apresentaram recidiva após a ressecção cirúrgica, diagnosticada entre o primeiro e o oitavo ano de seguimento. Devido ao comportamento clínico semelhante da displasia fibrosa e do fibroma ossificante, o exame anatomopatológico é essencial para o diagnóstico diferencial. O acompanhamento clínico permanente desses pacientes é necessário para que as possíveis recidivas sejam diagnosticadas precocemente.
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Harman, M., Ş. ZeteroĞlu, H. Arslan, M. Şengül, and Ö. Etlik. "Predictive value of magnetic resonance imaging signal and contrast-enhancement characteristics on post-embolization volume reduction of uterine fibroids." Acta Radiologica 47, no. 4 (May 2006): 427–35. http://dx.doi.org/10.1080/02841850600557117.
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Purpose: To assess the magnetic resonance imaging (MRI) signal and contrast-enhancement features of uterine fibroids before and after embolization, and to determine whether or not there are pre-embolization MRI characteristics that predict the volume reduction of fibroids. Material and Methods: Uterine fibroid embolization (UFE) was carried out in 28 fibroids of 20 patients, all of whom were symptomatic. The patients were prospectively evaluated with T1-weighted, T2-weighted, and gadolinium-enhanced T1 MRI sequences before and 6 months after embolization. The relationship between the characteristics of MRI signal and contrast-enhancement features of fibroids before the procedure and the change in size of the lesions after treatment was investigated. Results: Before embolization, the mean volume of fibroids was 123 cm3 (8–560 cm3). The decrease rate in fibroid volumes was 44.6% (range 7–70%) 6 months after embolization. Volume reduction was more prominent in fibroids that had a high signal intensity on T2-weighted images and a marked contrast enhancement on T1-weighted images ( P<0.001). However, the volume reduction was insufficient in fibroids with high signal characteristics on pre-contrast T1-weighted images ( P<0.001). Conclusion: MRI is an effective method for revealing size and signal changes of fibroids after embolization. MRI signal characteristics and the contrast-enhancement pattern of fibroids before embolization can predict tumor volume reduction after embolization.
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Lehmann, Tanner, Alyssa E. Vaughn, Sudipta Seal, Kenneth W. Liechty, and Carlos Zgheib. "Silk Fibroin-Based Therapeutics for Impaired Wound Healing." Pharmaceutics 14, no. 3 (March 16, 2022): 651. http://dx.doi.org/10.3390/pharmaceutics14030651.
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Impaired wound healing can lead to local hypoxia or tissue necrosis and ultimately result in amputation or even death. Various factors can influence the wound healing environment, including bacterial or fungal infections, different disease states, desiccation, edema, and even systemic viral infections such as COVID-19. Silk fibroin, the fibrous structural-protein component in silk, has emerged as a promising treatment for these impaired processes by promoting functional tissue regeneration. Silk fibroin’s dynamic properties allow for customizable nanoarchitectures, which can be tailored for effectively treating several wound healing impairments. Different forms of silk fibroin include nanoparticles, biosensors, tissue scaffolds, wound dressings, and novel drug-delivery systems. Silk fibroin can be combined with other biomaterials, such as chitosan or microRNA-bound cerium oxide nanoparticles (CNP), to have a synergistic effect on improving impaired wound healing. This review focuses on the different applications of silk-fibroin-based nanotechnology in improving the wound healing process; here we discuss silk fibroin as a tissue scaffold, topical solution, biosensor, and nanoparticle.
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Holdsworth-Carson, Sarah J., Dong Zhao, Leonie Cann, Sophie Bittinger, Cameron J. Nowell, and Peter A. W. Rogers. "Differences in the cellular composition of small versus large uterine fibroids." Reproduction 152, no. 5 (November 2016): 467–80. http://dx.doi.org/10.1530/rep-16-0216.
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Uterine fibroids are clonally derived from a single cell; however, despite being monoclonal, the cellular phenotypes that make up uterine fibroids are heterogeneous consisting of predominantly smooth muscle cells (SMC) and fibroblasts. This raises the question as to when clonal cell differentiation occurs during fibroid development, and does this information provide clues about possible mechanisms regulating the growth process that leads to fibroids of symptom-causing size? This study investigated the differences in the cellular composition of fibroids by immunohistochemistry (IHC). A tissue microarray (n = 21 hysterectomy cases) was used for the investigation of large uterine fibroids and normal myometrium. An investigation of small fibroids (≤ 5mm) used a separate group of samples (n = 7 hysterectomy cases, total ofn = 17 fibroids). A panel of cell phenotypic markers was selected based on our previousin situinvestigations and included aldehyde dehydrogenase 1 (ALDH1A1) and vimentin for different fibroblast sub-populations, smooth muscle actin (SMA) as a marker for SMCs, CD31 for endothelial cells and CD45 for leucocytes. Proliferating cell nuclear antigen (PCNA) was also studied to identify proliferating cells. The cellular composition of small fibroids differs significantly from large fibroids. Small fibroids are more cellular (increased cells/mm2) than large fibroids, have more blood vessels and also have a higher ratio of SMC to fibroblasts than large fibroids. Large fibroids have more cell proliferation (measured by PCNA) and fewer leucocytes (measured by CD45) than adjacent myometrium, whereas small fibroids are less proliferative and have similar number of leucocytes to myometrium. Different cellular composition between fibroids of different sizes may provide important clues as to the mechanisms that drive fibroid growth.
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Mhatre, Shalaka Dilip, Ayushi Vazirani, and Vidhya Selvam. "Prospective study to assess the obstetric and perinatal outcome in fibroid complicating pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 3 (February 24, 2021): 1073. http://dx.doi.org/10.18203/2320-1770.ijrcog20210738.
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Background: Fibroids are the most common benign tumour of the uterus. Complications ranges from approximately 10-40% in fibroid complicating pregnancy. The objective of the study was to assess obstetric and perinatal outcomes in fibroid complicating pregnancy.Methods: A prospective study was carried out over a period of 01 June 2019-30 October 2020 on 42 women diagnosed with fibroid uterus in pregnancy. The study was conducted in the Obstetrics and Gynaecology department of Sree Balaji Medical College and Hospital, Chennai. Routine basic investigations were done. Ultrasonogram was done at booking visit and during subsequent visits to assess the increase in the size of the fibroid and degeneration and other obstetric complications such as malpresentation and placenta previa.Results: Major proportion was in the younger age group of 25-35 years. Fibroids were more frequent in multigravidae 34 (80.96%), and primigravidae were 8 (19.04%). The reported incidence of fibroid in pregnancy ranges from 0.01%-10.7%. 27 (64.28%) women were asymptomatic during pregnancy. Out of 42 women, 10 (23.80%) were known cases of fibroid became pregnant, remaining 32 (76.19%) were diagnosed as having fibroid during routine antenatal visits. 2 women (22.22%) had pain, 3 of them (7.14%) had preterm labor, 3 (7.14%) had spontaneous miscarriage, 6 (14.2) had threatened abortion, and 1(2.3%) had abruption placentae and 1(2.5%) had placenta previa. Out of 39, 27 (69.23%) women had vaginal delivery of which 2 (7.40%) women had assisted vaginal delivery. Lower segment cesarean section done in 12 women (30.76%). 32 babies delivered (82.05%) appropriate for gestational age infants, 3 (7.69%) had LBW, and 4 (10.25%) were IUGR.Conclusions: Fibroid complicating pregnancy are associated with complications during the antepartum, intrapartum, and postpartum period hence a regular follow up and evaluation is a must. Most pregnancies with fibroids are asymptomatic but may adversely affect the obstetric and perinatal outcome.
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Kale, Ashish R. "Ulipristal acetate (UPA) for fibroids–IVF outcomes following treatment with UPA after IVF failure: series of 2 case reports." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 7 (June 24, 2017): 3177. http://dx.doi.org/10.18203/2320-1770.ijrcog20172959.
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Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Fibroids are present in 5-10% of infertile patients, and may be the sole cause of infertility in 1-2.4%. The removal of fibroids by hysteroscopy and laparoscopy has now become the standard of care depending upon the size, number and location of fibroids in an infertile woman. Off lately, there is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids due to the use of selective progesterone receptor modulators (SPRMs) such as ulipristal acetate (UPA). Here, we report a case series of 2 women, with fibroids, who were put on UPA prior to IVF. These women had at least one previous IVF failure. The pre and post UPA fibroid characteristics were compared to see the effect of the drug. IVF was done post 3 month UPA therapy. Both the women showed a drastic reduction in the fibroid size, increased distance from endometrial cavity, and successful post UPA IVF cycles. Safety of the drug has been proven in few recent trials, but the role of UPA in infertile women with fibroids, who have had previous IVF failure, has opened new horizons in this field.
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Monleón, Javier, Alicia Martínez-Varea, Daniela Galliano, and Antonio Pellicer. "Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids." Case Reports in Obstetrics and Gynecology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/314587.
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This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial cavity were noted by transvaginal ultrasound after treatment. An endometrial biopsy excluded histologic endometrial changes. Three months after the end of UA the patient reported amenorrhea for 5 weeks and a clinical pregnancy was confirmed with transvaginal ultrasound. She underwent a subsequent uneventful pregnancy. Thus, the spontaneous pregnancy after UA to reduce fibroid size may support the potential clinical utility of this selective progesterone receptor modulator in the management of women with pregnancy desire and uterine fibroids after a prior myomectomy. Patients who refuse a new surgical procedure and/or those who are going to undergo assisted reproductive techniques would benefit from UA. It effectively shrinks fibroids, avoids risks of a new surgical procedure, and allows an immediate attempt at conception after the end of treatment.
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Sankaran, Suneela Mullakkal, and Jayasree Sukumara Pillai. "Fetomaternal outcome in fibroid complicating pregnancy: a retrospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 7 (June 28, 2021): 2613. http://dx.doi.org/10.18203/2320-1770.ijrcog20212330.
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Background: Fibroids are the commonest benign tumour arising from the smooth muscle from uterus. Effects of fibroids on pregnancy and the effects of pregnancy on fibroids are a frequent clinical concern since these tumors are common in women of reproductive age. Most pregnant women with fibroids do not have any complications during pregnancy related to the fibroids. Pain is the most common problem and there may be a slightly increased risk of obstetrical complications like miscarriage, preterm labor and delivery, malpresentation and placental abruption.Methods: A retrospective study was carried out to study the fetomaternal complications in fibroid complicating pregnancies. Duration of study period was one year. Study was from 1 January 2019 to 31 December 2019 in government medical college, Kozhikode. Patients beyond 28 weeks of gestational age with fibroid complicating pregnancies were included. Case records were reviewed from medical records library government medical college, Kozhikode. Detailed review of patients including history, examination and ultrasound scan reports, mode of delivery, antepartum, intrapartum, postpartum complications and details of babies were also taken.Results: During the study period a total of 112 cases of fibroid complicating pregnancies were included in the study out of 15875 total number of deliveries. Majority of patients belonged to age group between 30 to 35 years (40.17%) and 28.1% belonged to between 35 and40 years. 63.39% of patients were multies. In most of the cases fibroid was diagnosed by the first trimester ultra sound itself. Size of uterus remained corresponding to gestational age in more than half of cases (56.25%). There was increased incidence of caesarean delivery (56.25%), preterm delivery (7.2%) and placenta praevia (2.8%) postpartum haemorrhage (10.71%) in the studied cases.Conclusions: Fibriod complicating pregnancies are associated with higher incidence of obstetric complications during all the phases of pregnancy. Proper antenatal care and assessment can reduce the adverse outcomes to a greater extent.
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Aggarwal, Shikha, Maryam Rahim, Tarini Singh, and Debkalyan Maji. "A prospective study on association of primary infertility and fibroid uterus." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 6 (May 27, 2021): 2246. http://dx.doi.org/10.18203/2320-1770.ijrcog20212155.
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Background: Implication of fibroid uterus on infertility is still debateable. Co-existence of infertility and fibroid uterus has been observed many times in clinical practice. This study is conducted to ascertain the frequency of primary infertility in women suffering from fibroid.Methods: A prospective observational study was conducted at Altnagelvin hospital, Northern Ireland from July 2019 to December 2019. Total 100 patients were participated in the study. All data were collected and analysed using SPPS ver 20 software.Results: During the study period, a total of one hundred women presented with fibroid uterus were observed. All the cases were within the reproductive age group ranging from 20-43 years of age. 40% for cases were between 20-27 years, 49% cases were between 28-35 years and 11% belonged to 36-43 years of age. Considering the symptoms, infertility was 14%. According to the number of fibroids, in 22% of cases, there were multiple fibroids. The single uterine fibroid was seen in 78% of cases.Conclusions: Fibroid is relatively common in patients of reproductive age and was associated with infertility in 14% of cases.