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Journal articles on the topic 'Fibrosarcome'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Boufettal, H., M. Noun, Z. Rochdi, S. Mahdaoui, S. Hermas, and N. Samouh. "Fibrosarcome du col utérin." Journal de Radiologie 91, no. 12 (December 2010): 1307–8. http://dx.doi.org/10.1016/s0221-0363(10)70199-2.

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2

Ouarab, M., S. Fnini, M. Rahmi, D. Cohen, and M. Trafeh. "Fibrosarcome à localisation digitale." Annales de Chirurgie de la Main et du Membre Supérieur 14, no. 4-5 (January 1995): 235–38. http://dx.doi.org/10.1016/s0753-9053(05)80421-1.

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3

Decroisette, C., B. Melloni, D. Moldovan, V. Gazaille, V. Fermeaux, F. Bertin, and F. Bonnaud. "Métastases pleurales d’un fibrosarcome épithélioïde sclérosant." Revue de Pneumologie Clinique 62, no. 3 (June 2006): 179–82. http://dx.doi.org/10.1016/s0761-8417(06)75435-9.

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4

Aicardi, S., L. Durin, P. Bailleul, C. Jeanne-Pasquier, M. Dreyfus, and M. Herlicoviez. "Fibrosarcome de membre inférieur de diagnostic anténatal." Journal de Gynécologie Obstétrique et Biologie de la Reproduction 33, no. 2 (April 2004): 166. http://dx.doi.org/10.1016/s0368-2315(04)96436-8.

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5

Gilani, S. M., A. Raza, and B. M. Al-Khafaji. "Fibrosarcome améloblastique : une tumeur odontogène maligne rare." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 131, no. 1 (February 2014): 39–42. http://dx.doi.org/10.1016/j.aforl.2013.05.004.

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6

Raherinantenaina, F., M. F. Ralahy, A. Rohimpitiavana, and H. J. C. Razafimahandry. "Un nouveau cas de fibrosarcome à localisation digitale." Chirurgie de la Main 33, no. 6 (December 2014): 396–400. http://dx.doi.org/10.1016/j.main.2014.07.009.

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7

Sassi, S. H., R. Dhouib, S. Ben Dhaou, K. Mrad, M. Driss, I. Abbes, H. Arbi, H. Haourai, and K. Ben Romdhane. "À propos d’un cas de fibrosarcome épithélioïde sclérosant." Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Moteur 94, no. 1 (February 2008): 92–95. http://dx.doi.org/10.1016/j.rco.2007.10.004.

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8

Lagree, M., F. Toutain, Y. Revillon, G. Gaussin, A. Marie-Cardine, F. Lemoine, and J. P. Vannier. "Fibrosarcome infantile récidivant et métastatique : à propos d’un cas." Archives de Pédiatrie 18, no. 1 (January 2011): 28–32. http://dx.doi.org/10.1016/j.arcped.2010.10.004.

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9

Martin, Hélène, Anne-Laure Liegeon, Jean-François Cuny, Jean-Luc Schmutz, François Truchetet, and Amélie Schoeffler. "Fibrosarcome épithélioïde sclérosant thoracique compliquant le port d’un pendentif radioactif." La Presse Médicale 46, no. 10 (October 2017): 971–73. http://dx.doi.org/10.1016/j.lpm.2017.05.033.

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10

Raquillet, C., S. Branchereau, F. Boman, D. Berrebi, M. Fabre, J. Michon, A. Gaudin, P. Fréneaux, A. El Ghoneimi, and P. Philippe-Chomette. "P187 - Fibrosarcome infantile du grêle compliqué de perforation digestive néonatale." Archives de Pédiatrie 17, no. 6 (June 2010): 97. http://dx.doi.org/10.1016/s0929-693x(10)70587-x.

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11

Cissé, M., L. Machet, A. Le Touze, M. C. Machet, O. Lejars, and G. Lorette. "Fibrosarcome infantile simulant un hémangiome type rapidly involuting congenital hemangioma (RICH)." Annales de Dermatologie et de Vénéréologie 135, no. 1 (January 2008): 53–57. http://dx.doi.org/10.1016/j.annder.2007.01.002.

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12

Baroudjian, B., C. Pagès, M. Battistella, C. Lemaignan, J. Roux, D. Gossot, C. Farges, M. Bagot, and C. Lebbé. "Efficacité du pazopanib dans le dermato-fibrosarcome métastatique résistant à l’imatinib." Annales de Dermatologie et de Vénéréologie 143, no. 12 (December 2016): S403. http://dx.doi.org/10.1016/j.annder.2016.09.654.

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13

Yalçin, Bilgehan, Gürsel Leblebicioğlu, Elif Güler, Gökhan Gedikoğlu, and M. Tezer Kutluk. "Congenital Infantile Fibrosarcoma of the Thigh in a Newborn." Tumori Journal 87, no. 6 (November 2001): 436–38. http://dx.doi.org/10.1177/030089160108700616.

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Congenital/infantile fibrosarcoma occurs frequently in the first year of life and differs from fibrosarcoma in adulthood. The clinical course of congenital/infantile fibrosarcoma is more favorable and metastatic spread is rare. While adult fibrosarcomas are common in the thigh, congenital/infantile fibrosarcomas affect chiefly the distal portions of the extremities. Standard treatment is primarily wide surgical excision. Chemotherapy may be given as neoadjuvant or adjuvant treatment in order to avoid the morbidity associated with wide excision. In this case report we present our experience of a newborn affected by congenital/infantile fibrosarcoma of the left thigh.

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14

Kesrouani, Carole, Leila Zemoura, Martine Trassard, and Marick Laé. "Une lésion hybride : sarcome fibromyxoïde de bas grade (SFBG) et fibrosarcome épithélioïde sclérosant (FES)." Annales de Pathologie 36, no. 5 (October 2016): 351–54. http://dx.doi.org/10.1016/j.annpat.2016.07.002.

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15

Blostin, R., and C. Faivre. "Bénéfices du gui fermenté chez le chat après exérèse de fibrosarcome. Résultats d’une étude préliminaire." Phytothérapie 6, no. 6 (December 2008): 352–58. http://dx.doi.org/10.1007/s10298-008-0348-5.

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16

Mrad, S. Tebra, S. Belajouza, M. Mokni, H. Khairi, S. Korbi, and N. Bouaouina. "À propos d'un cas de fibrosarcome pariétal radio-induit après traitement d'un cancer du sein." Cancer/Radiothérapie 10, no. 6-7 (November 2006): 523–24. http://dx.doi.org/10.1016/j.canrad.2006.09.083.

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17

Malat, Jan, Chat Virapongse, Christopher J. Palestro, and Alan H. Richman. "Primary Intraspinal Fibrosarcoma." Neurosurgery 19, no. 3 (September 1, 1986): 434–36. http://dx.doi.org/10.1227/00006123-198609000-00016.

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Abstract Fibrosarcomas of dura mater are very rare tumors representing only 0.5% of all central nervous system sarcomas. A higher incidence of dural fibrosarcomas has been reported in patients with neurofibromatosis. We present a case of spinal dura mater fibrosarcoma in a patient without neurofibromatosis. The diagnostic and therapeutic strategy in the clinical management is discussed.

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18

Chopra, Ruchi, Minakshi Bhardwaj, and Ishwar Chand Premsagar. "Fibrosarcoma of the meninges." Rare Tumors 2, no. 1 (March 1, 2010): 8–9. http://dx.doi.org/10.4081/rt.2010.e3.

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Meningeal fibrosarcomas are rare tumors. Only 41 cases have been reported in the literature to date. Primary central nervous system fibrosarcomas are very aggressive neoplasms and have a poor prognosis. Hence they need to be correctly diagnosed. This is a case of a 13-year old boy with intracranial space occupying lesion. The mass was completely removed and histological examination was characteristic of meningeal fibrosarcoma. The pathological diagnosis is usually made on routine light microscopic examination; however, occasionally these may be difficult to distinguish from other malignant neoplasms such as gliomas, meningiomas and metastases. The diagnosis of fibrosarcoma is based on the identification of a predominant herringbone architectural pattern, the overall uniformity of the spindle cell population, the prominent vimentin positivity, and the presence of pericellular reticulin fibre network. IHC helps to exclude other diagnoses.

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19

Hersant, B., P. May, M. Battistella, C. Pages, C. Lebbe, and M. Revol. "Technique verticale modifiée et réduction des marges d’exérèse dans le dermato-fibrosarcome de Darier et Ferrand." Annales de Dermatologie et de Vénéréologie 139, no. 12 (December 2012): B215. http://dx.doi.org/10.1016/j.annder.2012.10.368.

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20

Canale, S., C. Caramella, D. Couanet, D. Vanel, and C. Dromain. "RP-WS-19 Fibrosarcome infantile : donnees de l’imagerie par resonance magnetique sur une serie de 6 cas." Journal de Radiologie 89, no. 10 (October 2008): 1621. http://dx.doi.org/10.1016/s0221-0363(08)77084-7.

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21

Vernier, N., G. Muller, P. Bielefeld, A. Turcu, H. Devilliers, M. Legendre, C. Laborde, et al. "Une pleurésie à éosinophiles révélant un rarissime fibrosarcome sclérosant épithélioïde au cours d’une granulomatose éosinophilique avec polyangéïte." La Revue de Médecine Interne 37 (June 2016): A144. http://dx.doi.org/10.1016/j.revmed.2016.04.112.

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22

Valdèz, J. C., M. Rachid, N. Gobbato, and G. Perdigòn. "Apoptosis Study in Thymic Involution in Tumour-Bearing Mice." International Journal of Immunopathology and Pharmacology 11, no. 2 (May 1998): 49–55. http://dx.doi.org/10.1177/039463209801100201.

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By using a colorectal carcinoma induced by s.c. injection of 1,2-dimethylhydrazine and a transplantable fibrosarcoma developed in inbred BALB/c mice 6–8 weeks old we found that tumour development was accompanied by a remarkable thymic involution. Mice bearing small fibrosarcoma or carcinoma (0,05 cm3) had thymuses and spleens with the same weight as those of normal mice. Thymic atrophy and splenomegalia developed in mice bearing large fibrosarcoma (5,00 cm3) and large carcinoma (0,20 cm3). Thymic involution was not the result of an increase in spontaneous cellular apoptosis. However, an increased susceptibility to apoptosis induced by etoposide was observed in thymocytes from mice bearing large carcinomas or large fibrosarcomas, as compared to the same cells derived from normal or small tumour-bearing mice. Dexamethasone induced comparable levels of apoptosis in thymocytes from all groups (normal mice, mice bearing small and large carcinoma and mice bearing small and large fibrosarcoma); doxorrubicin had no significant effect in any group.

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23

Hanes, M. A. "Fibrosarcomas in Two Rats Arising from Hepatic Cysts of Cysticercus fasciolaris." Veterinary Pathology 32, no. 4 (July 1995): 441–44. http://dx.doi.org/10.1177/030098589503200418.

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Two of five male Sprague-Dawley rats with hepatic tapeworm cysts developed large multinodular fibrosarcomas. Fibrosarcomas enveloped tapeworm cysts, invaded the serosa of multiple organs, and extended through the diaphragm into the pleural cavity. Light microscopy, immunohistochemistry, and electron microscopy supported the diagnosis of fibrosarcoma. The parasites were identified as Cysticercus fasciolaris, the larval stage of Taenia taeniaeformis. The development of sarcomas in rats induced by Taenia sp. is thought to be attributable to the chronic inflammatory reaction of the capsule. There are parallels between these and other tumors occurring in mice and cats with suggested chronic inflammatory etiologies.

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24

Wang, Hexiang, Pei Nie, Cheng Dong, Jie Li, Yonghua Huang, Dapeng Hao, and Wenjian Xu. "CT and MRI Findings of Soft Tissue Adult Fibrosarcoma in Extremities." BioMed Research International 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/6075705.

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Objective. To characterize and evaluate CT and MRI features of extremity soft tissue adult fibrosarcoma. Methods. CT and MRI images from 10 adult patients with pathologically proven fibrosarcomas were retrospectively analyzed with regard to tumor location, size, number, shape, margins, attenuation, signal intensity, and enhancement patterns on MR images. Additionally, the relationships between lesions, deep fascia, and change in adjacent bones were also assessed. Results. Nineteen tumor lesions in 10 patients were selected for this study. Eighteen lesions were lobulated and one was oval in shape. Most cases were located under the deep fascia, including seven cases that had a nodular lump adjacent to the deep fascia and one case that had broken lesion through the deep fascia. On CT, the adult fibrosarcomas mostly showed iso-attenuated soft tissue masses (n=6). On MRI, all the cases (n=9) displayed low signal on T1-weighted imaging (T1WI) and heterogeneous low and high intensity signals on T2-weighted imaging (T2WI), with band-like areas of low signal on both T1WI and T2WI. On contrast-enhanced MRI images, three cases showed heterogeneous peripheral enhancement and one case demonstrated a spoke-wheel-like enhancement. Eight cases showed muscle edema signals in the peritumoral muscle and one case involved adjacent bone. Conclusion. CT and MR imaging have respective advantages in diagnosing adult fibrosarcoma. Combined application of CT and MR is recommended for patients with suspected adult fibrosarcoma.

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Alameda, Yadiel A., Carlos Perez-Mitchell, and José M. Busquets. "Nasal Cavity Ossifying Fibrosarcoma: An Unusual Fibro-Osseous Neoplasm." Ear, Nose & Throat Journal 89, no. 11 (November 2010): E1—E3. http://dx.doi.org/10.1177/014556131008901101.

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We describe the case of a 65-year-old woman who presented with left nasal obstruction. Clinical and radiographic examinations revealed the presence of a soft-tissue mass that had obliterated the left nasal cavity. The mass was completely excised via an endoscopic approach. Histopathologic examination identified the tumor as an ossifying fibrosarcoma. The patient recovered uneventfully and remained free of disease at the 2-year postoperative follow-up. To the best of our knowledge, no case of an ossifying fibrosarcoma of the nasal cavity has been previously reported in the English-language literature. We discuss the features of this case and the clinical presentation, diagnosis, and management of fibrosarcomas of the nasal cavity and paranasal sinuses.

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26

Nechi, S., R. Dhouib, R. Doghri, L. Charfi, S. Sassi, I. Abess, M. Driss, K. Mrad, and K. Ben Romdhane. "Expression du Ki67 et du P53 dans le dermato-fibrosarcome de Darier et Ferrand dans sa variante fibrosarcomateuse : intérêt pronostique." Annales de Dermatologie et de Vénéréologie 139, no. 12 (December 2012): B245. http://dx.doi.org/10.1016/j.annder.2012.10.436.

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27

Nikitovic, Dragana, Katerina Kouvidi, Nikos K. Karamanos, and George N. Tzanakakis. "The Roles of Hyaluronan/RHAMM/CD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/929531.

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Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that surround and support cells within tissues. During cancer progression, significant changes can be observed in the structural and mechanical properties of the ECM components. Importantly, hyaluronan deposition is usually higher in malignant tumors as compared to benign tissues, predicting tumor progression in some tumor types. Furthermore, activated stromal cells are able to produce tissue structure rich in hyaluronan in order to promote tumor growth. Key biological roles of HA result from its interactions with its specific CD44 and RHAMM (receptor for HA-mediated motility) cell-surface receptors. HA-receptor downstream signaling pathways regulate in turn cellular processes implicated in tumorigenesis. Growth factors, including PDGF-BB, TGFβ2, and FGF-2, enhanced hyaluronan deposition to ECM and modulated HA-receptor expression in fibrosarcoma cells. Indeed, FGF-2 through upregulation of specific HAS isoforms and hyaluronan synthesis regulated secretion and net hyaluronan deposition to the fibrosarcoma pericellular matrix modulating these cells’ migration capability. In this paper we discuss the involvement of hyaluronan/RHAMM/CD44 mediated signaling in the insidious pathways of fibrosarcoma progression.

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28

Sun, Fei, Javier Hernández, Javier Ezquerra, Esther Durán, Luis-Fernando Pineda, Carmen De Miguel, Verónica Crisóstomo, Jesús Usón, and Manuel Maynar. "Angiographic Study and Therapeutic Embolization of Soft-Tissue Fibrosarcoma in a Dog: Case Report and Literature." Journal of the American Animal Hospital Association 38, no. 5 (September 1, 2002): 452–57. http://dx.doi.org/10.5326/0380452.

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A case of soft-tissue fibrosarcoma with pulmonary metastases in a dog is reported. Although three attempts of fine-needle aspiration (FNA) biopsy failed to provide definitive tumor diagnosis, results of angiography strongly indicated a soft-tissue sarcoma. Transcatheter arterial embolization (TAE) using particles of gelatin sponge was performed following selective angiography. The mass was decreased in size on reevaluation 2 weeks after embolization. The dog was euthanized on the request of the owners due to overall failing health. Necropsy and pathological study confirmed the diagnosis of soft-tissue fibrosarcoma with pulmonary metastases. In a review of the literature, angiographic findings of soft-tissue sarcoma in the dog of this report were similar to those in human beings, suggesting a potential role for angiography in the differential diagnosis of suspect soft-tissue fibrosarcomas and for guiding FNA or surgical biopsy. Previous reports have also shown therapeutic embolization to be an effective treatment both in experimental animal study and in clinical practice in the human; therefore, TAE could be an effective adjunctive treatment of soft-tissue fibrosarcoma in the dog.

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29

De Man, Marc MG, and Richard V. Ducatelle. "Bilateral subcutaneous fibrosarcomas in a cat following feline parvo-, herpes- and calicivirus vaccination." Journal of Feline Medicine and Surgery 9, no. 5 (October 2007): 432–34. http://dx.doi.org/10.1016/j.jfms.2007.05.002.

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A crossbred cat developed a subcutaneous fibrosarcoma on the left side of the thorax at the site of previous administration of a feline parvo-, herpes- and calicivirus vaccine. A few months later the cat developed a second mass on the right side of the thorax after a booster vaccine had been administered at this site. This unique case of bilateral fibrosarcomas in a cat shortly after vaccination with parvo-, herpes- and caliciviruses suggests an individual disposition for the development of vaccine-associated sarcomas and a possible triggering of this type of pathological response which could have precipitated the development of the second tumour. To the authors' knowledge, this is the first case of vaccine-induced fibrosarcomas occurring bilaterally after injection of a feline parvo-, herpes- and calicivirus containing vaccine at different sides of the thorax.

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30

Madej, Janusz A., Jan P. Madej, Piotr Dzięgiel, Bartosz Puła, and Marcin Nowak. "Correlation between expressions of hypoxia -inducible factor (HIF-1α), blood vessels density, cell proliferation, and apoptosis intensity in canine fibromas and fibrosarcomas." Bulletin of the Veterinary Institute in Pulawy 58, no. 1 (March 1, 2014): 117–23. http://dx.doi.org/10.2478/bvip-2014-0019.

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Abstract The study aimed to demonstrate the expression of hypoxia-inducible factor (HIF-1α) in soft tissue mesenchymal tumours (fibroma and fibrosarcoma) in dogs. An attempt was made to correlate the obtained results with density of blood vessels (expression of von Willebrand Factor, vWF), expression of Ki-67 proliferation antigen, and with intensity of apoptosis in studied tumours. The study was performed on paraffin sections of 15 fibromas and 40 fibrosarcomas sampled from 55 female dogs aged 6 to 16 years. Immunohistochemical staining against HIF-1α, vWF, and Ki-67 was performed. Apoptosis was detected with the use of TUNEL reaction. A significantly higher HIF-1α expression was noted in fibrosarcomas in comparison to fibromas (P < 0.0001). HIF-1α expression in fibromas manifested strong positive correlation with tumour vascularity (r = 0.67, P = 0.007). Moreover, HIF-1α expression in fibrosarcomas manifested a moderate positive correlation with tumour malignancy grade (r = 0.44, P = 0.004), tumour vascularity (r = 0.52, P < 0.001), Ki-67 antigen expression (r = 0.42; P = 0.007), and TUNELpositive cells (r = 0.37, P = 0.017). Expression of HIF-1α was detected in 86.7% of fibroma type tumours and in 100% of fibrosarcomas. In all studied tumours expression of HIF-1α manifested positive correlation with the density of blood vessels, and in fibrosarcomas it correlated also with malignancy grade, intensity of Ki-67 expression, and with intensity of apoptosis in tumour cells.

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31

VP, Vinodh, Rahmat Harun, Pulivendhan Sellamuthu, and Regunath Kandasamy. "Primary Central Nervous System Fibrosarcoma." Journal of Neurosciences in Rural Practice 08, S 01 (August 2017): S111—S113. http://dx.doi.org/10.4103/jnrp.jnrp_165_17.

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ABSTRACTWe report a rare case of a young female with primary brain fibrosarcoma, and to the best of our knowledge, we believe that only <50 cases have been reported or described worldwide so far. Fibrosarcoma is a malignant neoplasm, in which histologically the predominant cells are fibroblasts that divide excessively without cellular control and they can invade local tissues or metastasize. Primary central nervous system fibrosarcomas are very aggressive neoplasms and generally have a poor prognosis. This tumor is either from sarcomatous transformation of a meningioma or arises de novo within the brain parenchyma. Our patient, a 48-year-old woman, who presented with progressive speech disorder over the period of 4 months, showed a left temporoparietal lesion with surrounding edema and local mass effect. Total surgical resection was achieved. Histopathology revealed classical fibrosarcoma features and secondary screening revealed no other distant lesion as diagnosis of primary brain fibrosarcoma was established. This case is deemed to be extremely rare because most reports claim that recurrence is within 6 months with poor prognosis; however, this patient is currently recurrence-free at 3 years. This would suggest of the possibility for a relook into this disease's course and recurrence rate when complete excision is achieved. Due to extreme rarity of these tumors, more comparative studies will be needed to improve the disease outcome.

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Kochbati, L., H. Boussen, S. Gritli, M. Besbes, F. Benna, A. Saadi, A. El May, F. Ben Ayed, A. Ladgham, and M. Maalej. "Fibrosarcome secondaire de la mandibule après chimioradiothérapie pour carcinome indifférencié du nasopharynx. À propos d’une observation et revue de la littérature." Cancer/Radiothérapie 5, no. 3 (June 2001): 283–86. http://dx.doi.org/10.1016/s1278-3218(01)00101-9.

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33

Ahmed, Ishtiaq. "Proliferating Cell Nuclear Antigen Expression in Canine and Feline Spontaneous and Injection-site Fibrosarcomas." Pakistan Veterinary Journal 40, no. 04 (December 1, 2020): 531–33. http://dx.doi.org/10.29261/pakvetj/2020.019.

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Fibrosarcoma, a tumor composed of spindloid fibroblasts, is grouped in soft tissue sarcomas which constitute one of the most important tumors in companion animals. Cell proliferation index is a good indicator of the biological behavior of the tumors which is estimated either by mitotic index or cell proliferation markers. In the current study, we investigated the immunohistochemical expression of proliferating cell nuclear antigen (PCNA) in spontaneous and injection-site fibrosarcomas in dogs and cats. A positive correlation was noticed between the PCNA expression, mitotic index, tumor grade and degree of differentiation of the tumor cells in tumors from both of these species. PCNA expression was significantly different between different tumor grades in dogs and cats. It can be concluded from this study that PCNA is a useful marker for predicting the outcome of the canine and feline fibrosarcomas

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Eikelberg, Deborah Johanna, Lisa Allnoch, Pierre Grothmann, Julia Bohner, and Marion Hewicker-Trautwein. "Subcutaneous fibrosarcomas with pulmonary metastases in a white tiger (Panthera tigris) and a lion (Panthera leo)." Veterinary Record Case Reports 8, no. 2 (April 2020): e000960. http://dx.doi.org/10.1136/vetreccr-2019-000960.

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Two cases of recurrent subcutaneous fibrosarcomas in a white tiger and a lion were observed and the animals were euthanised humanely due to clinical deterioration. In both animals, postmortem examination revealed multinodular, white to fawn, firm to greasy, subcutaneous masses at the left side of the thorax infiltrating into the adjacent musculature. Furthermore, the tiger showed a single mass and the lion multiple masses in the lung. Histopathologically, the subcutaneous and pulmonary masses consisted of spindle-shaped neoplastic cells with necrotic areas, and infiltration with multinucleated giant cells and lymphocytes. Immunohistochemically, tumour cells labelled positive for vimentin and negative for desmin, factor VIII-related antigen, smooth muscle actin S100, CD31 and nerve growth factor receptor p75. Thus, the pulmonary tumours were diagnosed as metastases of subcutaneous fibrosarcomas. Like domestic cats, also large, non-domestic felids could be predisposed for metastasising fibrosarcoma, which may be associated with injections or trauma.

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35

Bist, SS, Sarita Mishra, Vinish Agrawal, and Meena Harsh. "Soft Tissue Fibrosarcoma Neck Mimicking as Thyroid Swelling." An International Journal of Otorhinolaryngology Clinics 6, no. 1 (2014): 50–52. http://dx.doi.org/10.5005/jp-journals-10003-1150.

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ABSTRACT Fibrosarcomas are relatively uncommon tumors, commonly arise in the extremities; approximately 10% occur in the head and neck region, most commonly in the sinonasal tract and neck. We hereby report a case of fibrosarcoma in neck clinically mimicking as a thyroid swelling in a 14 years old boy. The patient reported with difficulty in breathing along with stridor at the time of presentation so endotracheal intubation was done to secure the airway. Subsequent ultrasonography guided fine needle aspiration cytology (FNAC) showed atypical cells suggestive of mesenchymal origin. Contrast-enhanced computed tomography scan showed a large heterogeneously enhancing mass lesion in right side of neck with retrosternal extension, while the right lobe of thyroid was displaced superiorly and left lobe was normal. We performed a complete surgical excision of the tumor and histopathological examination showed intermediate to high grade spindle cell sarcoma, favoring fibrosarcoma. Postoperative period was uneventful and the patient was referred to oncology unit for radiotherapy and chemotherapy, but the patient succumbed to the disease 5 weeks after surgery. How to cite this article Bist SS, Mishra S, Varshney S, Agrawal V, Harsh M. Soft Tissue Fibrosarcoma Neck Mimicking as Thyroid Swelling. Int J Otorhinolaryngol Clin 2014; 6(1):50-52.

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Tupkari, Jagdish Vishnu, Tabita Joy Chettiakandy, Dimple Padawe, Keshav Kumar, Manisha Sardar, and Nandita Gupta. "Intraoral Soft Tissue Fibrosarcoma: A Case Report and Review." Journal of Contemporary Dentistry 4, no. 2 (2014): 118–23. http://dx.doi.org/10.5005/jp-journals-10031-1080.

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ABSTRACT Adult fibrosarcoma (FS), defined by the World Health Organization as ‘malignant neoplasm composed of fibroblasts with variable collagen production and, in classical cases, a ‘herringbone’ architecture’, is a very rare soft tissue sarcoma. The earlier literature revealed that the adult fibrosarcoma was the most commonly occurring lesion, however the incidence of which has declined dramatically over the past several decades. This is due to evolution in the classification of soft tissue tumors, recognition of its subtypes and increased understanding of the many other mesenchymal and nonmesenchymal tumors. Sarcomas are the rare group of malignancies which accounts for less than 1% of all the body sarcomas of which 5 to 15% occurs in head and neck region. It involves deep soft tissues of extremities, trunk, head and neck. Among the head and neck region, intraoral adult fibrosarcomas are very rare without any sex predilection. A case of primary soft tissue FS in posterior mandible of an 13-year-old female patient is documented here, which will be an addition to the cases reported earlier in the literatures. How to cite this article Tupkari JV, Chettiakandy TJ, Padawe D, kumar k, Sardar M, Gupta N. Intraoral Soft Tissue Fibrosarcoma: A Case Report and Review. J Contemp Dent 2014;4(2):118-123.

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García Jiménez, Angel, Josep Castellví, Assumpció Pérez Benavente, Isabela Díaz de Corcuera Frutos, and Santiago Ramón y Cajal. "Ovarian Fibrosarcoma: Clinicopathologic Considerations about the Intraoperative and Post-Surgical Procedures." Case Reports in Medicine 2009 (2009): 1–4. http://dx.doi.org/10.1155/2009/802817.

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Primary ovarian fibrosarcomas are very uncommon neoplasms. Since the diagnostic criteria were established in 1981, less than one hundred cases have been reported. This diagnosis can be difficult to establish and other similar appearing mesenchymal processes must be ruled out. In every case this diagnosis is under consideration. Multiple sections of the specimen and immunohistochemical stains will be necessary to support this diagnosis. The difficulty of recognition in frozen section in the majority of the situations implies that the diagnosis should be deferred to the definitive study of the permanent sections with immunohistochemical studies. There exists a histological resemblance between a primary ovarian fibrosarcoma and actively mitotic fibroma. In some cases, it can be impossible to separate exactly these two entities. We report a well-differentiated ovarian fibrosarcoma, with less than 1-2 mitosis HPF and low-grade cytological atypia, similar to active mitotic fibromas, developing liver metastasis one year later. Despite having distant metastasis, some cases with long survival rates have been reported in patients who received chemotherapy after surgery; so that the adjuvant chemotherapy should be considered, especially in young females.

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Pirkey-Ehrhart, N., SJ Withrow, RC Straw, EJ Ehrhart, RL Page, HL Hottinger, KA Hahn, et al. "Primary rib tumors in 54 dogs." Journal of the American Animal Hospital Association 31, no. 1 (January 1, 1995): 65–69. http://dx.doi.org/10.5326/15473317-31-1-65.

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Fifty-four dogs with primary tumors of the rib were evaluated. Thirty-four dogs had osteosarcomas, 15 dogs had chondrosarcomas, three dogs had hemangiosarcomas, and two dogs had fibrosarcomas. Forty-nine dogs had en bloc excision. Within the osteosarcoma group, nine animals received postoperative adjuvant chemotherapy. These animals had significantly longer median disease-free intervals (225 days) and median survival times (240 days) than dogs with osteosarcoma treated by surgery alone (median disease-free interval, 60 days; median survival, 90 days). Chondrosarcoma had a better prognosis (median disease-free interval, 1,080 days; median survival, 1,080 days) than osteosarcoma, hemangiosarcoma, or fibrosarcoma of the rib. Age, weight, sex, number of ribs resected, tumor volume, and total cisplatin dose did not influence survival nor disease-free interval.

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Sippola-Thiele, M., D. Hanahan, and P. M. Howley. "Cell-heritable stages of tumor progression in transgenic mice harboring the bovine papillomavirus type 1 genome." Molecular and Cellular Biology 9, no. 3 (March 1989): 925–34. http://dx.doi.org/10.1128/mcb.9.3.925.

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Tumorigenesis of dermal fibroblasts in a line of transgenic mice carrying the BPV-1 genome was found to involve distinct proliferative stages. Cell cultures derived from normal skin, from benign proliferative fibromatoses, and from malignant fibrosarcomas each evidenced distinguishable, cell-heritable characteristics. The latent viral genome was transcriptionally inactive in normal-appearing skin and was activated in the dermal fibromatoses. Fibrosarcoma cells grew continuously in culture, formed domelike foci, and had a more rounded, anaplastic appearance. Independent cultures derived from the fibromatoses varied in their proliferative characteristics, which correlated well with the levels of viral gene expression. In contrast, progression to malignancy was not accompanied by a further increase in transgene activity, which strongly implicated cellular genetic changes in the later stages of tumorigenesis.

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Sippola-Thiele, M., D. Hanahan, and P. M. Howley. "Cell-heritable stages of tumor progression in transgenic mice harboring the bovine papillomavirus type 1 genome." Molecular and Cellular Biology 9, no. 3 (March 1989): 925–34. http://dx.doi.org/10.1128/mcb.9.3.925-934.1989.

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Tumorigenesis of dermal fibroblasts in a line of transgenic mice carrying the BPV-1 genome was found to involve distinct proliferative stages. Cell cultures derived from normal skin, from benign proliferative fibromatoses, and from malignant fibrosarcomas each evidenced distinguishable, cell-heritable characteristics. The latent viral genome was transcriptionally inactive in normal-appearing skin and was activated in the dermal fibromatoses. Fibrosarcoma cells grew continuously in culture, formed domelike foci, and had a more rounded, anaplastic appearance. Independent cultures derived from the fibromatoses varied in their proliferative characteristics, which correlated well with the levels of viral gene expression. In contrast, progression to malignancy was not accompanied by a further increase in transgene activity, which strongly implicated cellular genetic changes in the later stages of tumorigenesis.

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Vysotskaya, O. V., A. I. Glukhov, Yu P. Semochkina, S. A. Gordeev, and E. Yu Moskaleva. "Telomerase activity, mTert gene expression and the telomere length in mouse mesenchymal stem cells in the late period after γ- and γ,n-irradiation and in the tumors developed from these cells." Biomeditsinskaya Khimiya 66, no. 3 (2020): 265–73. http://dx.doi.org/10.18097/pbmc20206603265.

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In proliferating normal and tumor cells, the telomere length (TL) is maintained by high telomerase activity (TA). In the absence of TA the TL maintenance involves a mechanism of alternative lengthening of telomeres (ALT). The aim of this study was to investigate the level of TA, the mTert expression and TL in cultured normal and transformed by γ- and γ,n-irradiation mesenchymal stem cells (MSCs) from mouse bone marrow, in sarcomas that developed after the transplantation of these cells into syngeneic mice, and in fibrosarcoma cell lines obtained from these tumors to find out the role of AT or ALT in maintaining TL in these cells. During prolonged cultivation of normal and transformed under the influence of γ- (1 Gy and 6 Gy) and γ,n-irradiation (0.05 Gy, 0.5 Gy, and 2 Gy) MSCs from mouse bone marrow, a decrease in TA was detected in irradiated cells. Even deeper decrease in TA was found in sarcomas developed after administration of transformed MSCs to syngeneic mice and in fibrosarcoma cell lines isolated from these tumors in which TA was either absent or was found to be at a very low level. TL in three of the four lines obtained was halved compared to the initial MSCs. With absent or low TA and reduced TL, the cells of all the obtained fibrosarcoma lines successfully proliferated without signs of a change in survival. The mechanism of telomere maintainance in fibrosarcoma cell lines in the absence of TA needs further investigation and it can be assumed that it is associated with the use of the ALT. The detected decrease or absence of TA in transformed under the action of irradiation MSCs with the preservation or even an increase in the telomerase gene expression may be associated with the formation of inactive splicing variants, and requires further study. The obtained lines of transformed MSCs and fibrosarcomas with TA and without the activity of this enzyme can be a useful model for studying the efficacy of TA and ALT inhibitors in vitro and in vivo.

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Hormati, Ahmad, Maryam Jameshorani, Saeid Sarkeshikian, Mohammad Reza Ghadir, and Faezeh Alemi. "A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report." Middle East Journal of Digestive Diseases 10, no. 4 (September 7, 2018): 258–62. http://dx.doi.org/10.15171/mejdd.2018.120.

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Accumulation of free fluid in the peritoneal cavity is called ascites. The first step in identifying its etiology is to determine the serum-ascites albumin gradient (SAAG). According to this parameter, a high SAAG is regarded as a gradient greater than 1.1 g/dL. This condition has some differential diagnoses such as liver cirrhosis, Budd-Chiari syndrome, heart failure, and idiopathic portal fibrosis. In the present article, we present a young man with abdominal distention due to a high SAAG. Further evaluation of the abdominal and thoracic cavity revealed a mass in the posterior mediastinum, which had compressed the inferior vena cava and left atrium and led to Budd-Chiari syndrome. Evaluation of the biopsy sample showed fibrosarcoma. Mediastinal fibrosarcomas, though rare, should be considered in the differential diagnosis of mediastinal masses.

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Patruno, Rosa, Giuseppe Passantino, Carmelo Laface, Antonella Tinelli, Alfredo Zito, Roberta Ruggieri, Francesco Luposella, et al. "Microvascular Density, Endothelial Area, and Ki-67 Proliferative Index Correlate Each Other in Cat Post-Injection Fibrosarcoma." Cells 10, no. 1 (December 28, 2020): 31. http://dx.doi.org/10.3390/cells10010031.

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Soft tissue sarcomas are a large group of different tumor types both in humans and in animals. Among them, fibrosarcoma is the most frequent malignant mesenchymal tumoral form in cats, representing up to 28% of all cat skin tumors, while human fibrosarcoma, fortunately, only represents 5% of all sarcomas and 0.025% of the world-wide burden of tumors. This low incidence in humans leads to consideration of this group of tumoral diseases as rare, so therapeutic options are few due to the difficulty of starting clinical trials. In this context, the identification of research models for fibrosarcomas could be of great interest to deepen knowledge in this field and recognize new or possible biological pathways involved in tumor progression and metastasis. Angiogenesis is considered a fundamental scattering cause of tumor aggressiveness and progression in all forms of cancer, but only a few research parameters were developed and reported to express them quantitatively and qualitatively. The role in angiogenesis of microenvironmental stromal cells, such as fibroblasts, lymphocytes, mast cells, and macrophages, was largely demonstrated since this topic was first approached, while quantification of new vessels and their blood capacity in tumoral area is a relatively recent approach that could be well developed thanks to expertise in immunohistochemistry and image analysis. In this paper, a crossing study evaluating microvascular density (MVD), endothelial area (EA), and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy. We aim to demonstrate that cat pets may be considered a useful animal model for better studying the correspondent human diseases and we report, for the first time to our knowledge, experimental data in terms of correlation among MVD, EA, and Ki-67 strictly involved in aggressiveness and tumoral progression.

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Talarico, D., M. M. Ittmann, R. Bronson, and C. Basilico. "A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas." Molecular and Cellular Biology 13, no. 4 (April 1993): 1998–2010. http://dx.doi.org/10.1128/mcb.13.4.1998.

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The K-fgf/hst oncogene encodes a growth factor of the fibroblast growth factor (FGF) family and transforms cells through an autocrine mechanism which requires extracellular activation of its receptor(s). To identify the cell and tissue targets of K-fgf oncogenic potential in vivo, we constructed a recombinant retrovirus carrying the human K-fgf cDNA and injected it, together with helper Moloney murine leukemia virus, into immunocompetent as well as nude mice. The original construct was highly transforming in tissue culture but produced no detectable pathologies in vivo with the exception of a single fibrosarcoma which arose after a long latency. The virus produced by this tumor appears to have undergone a complex series of recombination events involving the helper Moloney murine leukemia virus. It encodes an Env/K-FGF fusion protein whose expression is under the control of a hybrid long terminal repeat. This virus (designated MFS, for meningeal fibrosarcoma) induces tumors in mice with high frequency and short latency. These neoplasms consist of aggressive fibrosarcomas of soft tissue as well as diffuse meningeal tumors originating from the dura mater that surround the whole central nervous system and cause severe hydrocephalus. The Env/K-FGF fusion protein expressed by the MFS virus has retained all of the biological properties of native K-FGF, including secretion, mitogenic activity, heparin binding, and neutralization by anti-K-FGF antibodies. These and other results indicate that the tumors induced by the MFS virus result from the oncogenic potential of K-FGF.

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45

Talarico, D., M. M. Ittmann, R. Bronson, and C. Basilico. "A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas." Molecular and Cellular Biology 13, no. 4 (April 1993): 1998–2010. http://dx.doi.org/10.1128/mcb.13.4.1998-2010.1993.

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The K-fgf/hst oncogene encodes a growth factor of the fibroblast growth factor (FGF) family and transforms cells through an autocrine mechanism which requires extracellular activation of its receptor(s). To identify the cell and tissue targets of K-fgf oncogenic potential in vivo, we constructed a recombinant retrovirus carrying the human K-fgf cDNA and injected it, together with helper Moloney murine leukemia virus, into immunocompetent as well as nude mice. The original construct was highly transforming in tissue culture but produced no detectable pathologies in vivo with the exception of a single fibrosarcoma which arose after a long latency. The virus produced by this tumor appears to have undergone a complex series of recombination events involving the helper Moloney murine leukemia virus. It encodes an Env/K-FGF fusion protein whose expression is under the control of a hybrid long terminal repeat. This virus (designated MFS, for meningeal fibrosarcoma) induces tumors in mice with high frequency and short latency. These neoplasms consist of aggressive fibrosarcomas of soft tissue as well as diffuse meningeal tumors originating from the dura mater that surround the whole central nervous system and cause severe hydrocephalus. The Env/K-FGF fusion protein expressed by the MFS virus has retained all of the biological properties of native K-FGF, including secretion, mitogenic activity, heparin binding, and neutralization by anti-K-FGF antibodies. These and other results indicate that the tumors induced by the MFS virus result from the oncogenic potential of K-FGF.

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Hajdu, Steven I. "Fibrosarcoma." Cancer 82, no. 11 (June 1, 1998): 2081–89. http://dx.doi.org/10.1002/(sici)1097-0142(19980601)82:11<2081::aid-cncr1>3.0.co;2-z.

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Wilkins, Ross M., Richard A. McLeod, Herbert M. Reiman, and Douglas J. Pritchard. "Fibrosarcoma." Orthopedics 8, no. 1 (January 1985): 141–43. http://dx.doi.org/10.3928/0147-7447-19850101-22.

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Naik K., Smitha, Madhusudhan Astekar, and Dinesh Rao. "Soft tissue fibrosarcoma of pre maxillary region in an adult: report of a unique pathological entity." Clinics and Practice 2, no. 3 (May 18, 2012): 58. http://dx.doi.org/10.4081/cp.2012.e58.

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Fibrosarcoma of the oral and maxillofacial region is a rare entity with poor prognosis. Most common sites are the extremities, with only one percent of fibrosarcoma arising in the head and neck area. Oral fibrosarcoma are locally infiltrative and destructive, spreads by haematogenous dissemination. The positive immunostaining for vimentin, together with negativity for muscular immunomarkers help to diagnosis the fibrosarcoma. Surgical management of fibrosarcoma in maxillofacial region is far from satisfactory, because of lack of inadequate clearance. This paper describes an unusual case of soft tissue fibrosarcoma of premaxillary region in an adult aged 71 years.

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Spangler, W. L., M. R. Culbertson, and P. H. Kass. "Primary Mesenchymal (Nonangiomatous/Nonlymphomatous) Neoplasms Occurring in the Canine Spleen: Anatomic Classification, Immunohistochemistry, and Mitotic Activity Correlated with Patient Survival." Veterinary Pathology 31, no. 1 (January 1994): 37–47. http://dx.doi.org/10.1177/030098589403100105.

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Surgical submissions from canine splenectomy cases spanning a 3-year period (1988–1990) were evaluated. Eighty seven neoplasms of the spleen considered to be of nonangiomatous and nonlymphomatous origin were selected for morphologic classification, mitotic index determination, immunohistochemical analysis, and patient survival determination. In 76/87 cases, patient survival information was available, and the mitotic index was determined in 83/87 cases. Immunohistochemistry for selected antigens (vimentin, desmin, smooth muscle actin, myosin, and factor VIII-related antigen) was performed in 58/87 of the cases. Morphologic classification of these lesions in standard HE preparations yielded the following neoplastic groups: fibrosarcoma (19/87), undifferentiated sarcoma (19/87), leiomyosarcoma (14/87), osteosarcoma (8/87), mesenchymoma (7/87), myxosarcoma (6/87), histiocytic sarcoma (6/87), leiomyoma (3/87), lipoma-myelolipoma (2/87), liposarcoma (2/87), and malignant fibrous histiocytoma (1/87). A lack of distinct morphologic characteristics among many of the neoplasms that were classified as either fibrosarcoma, leiomyosarcoma, or undifferentiated sarcoma contrasted these groups with the relatively unambiguous features that distinguished the other sarcoma groups. Using immunohistochemical staining for muscle-specific antigens (desmin, smooth muscle actin, and myosin), specific staining often overlapped extensively within the neoplastic groups of fibrosarcomas, leiomyosarcomas, and undifferentiated sarcomas, suggesting either ambiguous morphologic findings or the possibility of a common histogenesis from smooth muscle trabeculae or a distinct population of splenic myofibroblasts. The biological behavior of all tumors examined could be placed into three categories of patient survival: (1) benign, noninvasive tumors (leiomyoma, lipoma) with prolonged survival intervals; (2) malignant tumors (fibrosarcoma, undifferentiated sarcoma, leiomyosarcoma, osteosarcoma, myxosarcoma, histiocytic sarcoma, and liposarcoma), showing severely truncated survival (median 4 months with 80–100% mortality after 12 months; and (3) intermediate survival periods (median 12 months with 50% 1 year survival) attributed to a single group of neoplasm, the mesenchymomas. The biological behavior of primary splenic nonangiomatous, nonlymphomatous sarcomas was most closely correlated with observed mitotic index. Splenic neoplasms of this type with a mitotic index < 9 showed significantly ( P < 0.0001) longer survival intervals than those with an index > 9. With the exception of osteosarcoma, all anatomically defined tumor groups contained one or more specimens with a mitotic index < 9. The clinical prognosis given for splenic sarcomas should be modified according to the mitotic index as a predictive value for patient survival.

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Annese, Tiziana, Roberto Ronca, Roberto Tamma, Arianna Giacomini, Simona Ruggieri, Elisabetta Grillo, Marco Presta, and Domenico Ribatti. "PTX3 Modulates Neovascularization and Immune Inflammatory Infiltrate in a Murine Model of Fibrosarcoma." International Journal of Molecular Sciences 20, no. 18 (September 17, 2019): 4599. http://dx.doi.org/10.3390/ijms20184599.

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Fibrosarcoma is an aggressive subtype of soft tissue sarcoma categorized in infantile/congenital-type and adult-type. Fibrosarcoma cells and its surrounding immune inflammatory infiltrates overexpress or induce the expression of fibroblast growth factor-2 (FGF-2) that have a crucial role in tumor progression and angiogenesis. The inflammation-associated long pentraxin 3 (PTX3) was found to reduce FGF-2-mediated angiogenesis, but its role on fibrosarcoma immune inflammatory infiltrate is still unknown. In this study, we have evaluated the PTX3 activity on immune infiltrating mast cells, macrophages and T-lymphocytes by immunohistochemistry on murine MC-TGS17-51 fibrosarcoma cells and on transgenic TgN(Tie2-hPTX3) mouse. In these fibrosarcoma models we found a reduced neovascularization and a significant decrease of inflammatory infiltrate. Indeed, we show that PTX3 reduces the level of complement 3 (C3) deposition reducing fibrosarcoma progression. In conclusion, we hypothesize that targeting fibrosarcoma microenvironment by FGF/FGFR inhibitors may improve treatment outcome.

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