To see the other types of publications on this topic, follow the link: Film forming formulation.
Journal articles on the topic 'Film forming formulation'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Film forming formulation.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Pünnel, Larissa Carine, and Dominique Jasmin Lunter. "Film-Forming Systems for Dermal Drug Delivery." Pharmaceutics 13, no. 7 (June 23, 2021): 932. http://dx.doi.org/10.3390/pharmaceutics13070932.
Full textAbstract:
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resistance and compared with conventional semi-solid formulations. Penetration and permeation studies of the formulations indicate a potential utility as transdermal therapeutic systems. They can be used as an alternative to patch systems to administer a variety of drugs in a topical way and may provide sustained release characteristics.
2
Jassim, Zainab E., Mais F. Mohammed, and Zainab Ahmed Sadeq. "FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF LORNOXICAM." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (September 7, 2018): 217. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.27098.
Full textAbstract:
Objective: The aim of the present work was to formulate and evaluate fast dissolving film containing lornoxicam.Materials and Methods: To prepare the film, hydroxypropyl methylcellulose E5 and polyvinyl alcohol (PVA) were used as film-forming polymers by solvent casting method. Glycerine was used as plasticizer, aspartame, and mannitol as sweetener. All prepared films were evaluated for its weight variation, disintegration time, thickness, drug content, pH, dissolution study, and folding endurance. The drug-excipients compatibility study was done using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR).Results: Satisfactory results obtained when PVA was used as film-forming polymer, and the drug was dispersed in the polymer solution using poloxamer 407 as a solubilizing agent. Formulation F2 is considered as the optimized formulation as it showed good folding endurance (>300), faster disintegration rate (30 s), and maximum in vitro drug release (87%) within 5 min. DSC and FTIR studies showed no interaction between drug and the polymers.Conclusion: It can be concluded from the study that the fast dissolving film can be prepared for poorly water-soluble drug lornoxicam using PVA as a suitable film-forming polymer.
3
Wayal, Vipul, K. Nagasree, and B. A. Vishwanath. "Design, Development and Evaluation of Silk Based Film Forming Spray for Wound Healing." Journal of Drug Delivery and Therapeutics 11, no. 3-S (June 15, 2021): 15–18. http://dx.doi.org/10.22270/jddt.v11i3-s.4812.
Full textAbstract:
The objective of the present study is to formulate and evaluate Silk based film forming spray for wound healing. On the wound surface the solution solidifies into a film which can deliver the active moiety on site of action. The spray solution was prepared by simple mixing of active extract of Centella Asiatica, Silk Protein and various film forming polymers. Silk protein form scaffold for active fibroblast movement and Asiaticosides from Centella Asiatica extract improve and fasten collagen synthesis. A clear yellowish solution was obtained. The formulations (F1-F8) had a pH range between 5.5–6.5, which was close to the pH of skin. The viscosity of formulation in range of 25–50 cps, completely dry film formed within 5 min in open environment. The Effects of polymers, plasticizers and solvents on spreadability. Surface tension and Spray angle were studied. The high content of ethanol in the formulation fastens the drying time. The results indicated that formulation (F8) showed good spreadability and less drying time.
Keywords: Film forming spray, Wound healing, Silk protein, Asiaticoside, Scaffold
4
T, Balakrishna, Vidyadhara S, Murthy Tegk, Ramu A, and Sasidhar Rlc. "FORMULATION AND EVALUATION OF ESOMEPRAZOLE FAST DISSOLVING BUCCAL FILMS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (October 7, 2018): 193. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27321.
Full textAbstract:
Objective: The present study deals with the formulation and evaluation of fast dissolving buccal films for effective treatment option in the gastroesophageal reflux disease.Methods: Esomeprazole fast dissolving buccal films are a convenient formulation of which can be taken with or without water. In the present investigation, polyvinyl alcohol and polyvinylpyrrolidone were used as film-forming agents and polyethylene glycol 400 is taken as plasticizer. Solvent evaporation method was used for the preparation of fast dissolving buccal films.Results: The films were prepared and evaluated for film thickness, folding endurance, dispersion test, drug content, and dissolution. The in vitro dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer).Conclusion: Among all the formulations, Formulation E7 was released up to 99.6% of the drug from the film within 5 min of time which exhibits faster absorption and also shows desirable characteristics of the film. The drug-excipient interaction studies WERE carried out by Fourier-transform infrared studies, differential scanning calorimetry analysis-X-diffraction studies, and scanning electron microscopic studies and the results revealed that there were no major interactions between the drugs and excipients used for the preparation of films.
5
Kaza, Rajesh, Sujatha Kumari M, Kishore Babu M, Avinash A, and Nagaraju R. "Biopharmaceutical and Pharmacodynamic Characteri-stics of Telmisartan Oral Disintegrating Films." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 2 (March 31, 2019): 4489–96. http://dx.doi.org/10.37285/ijpsn.2019.12.2.6.
Full textAbstract:
This research work was aimed to develop the telmisartan fast dissolving films. Fast dissolving films allow rapid drug dissolution in the oral cavity and thereby bypass the first pass metabolism. Solid dispersions of telmisartan using natural polymers such as hupu gum (HG), guar gum (GG) and xanthan gum (XG) were prepared by kneading technique and the optimized solid dispersion was exploited in the development of rapidly dissolving film. Telmisartan films were prepared by solvent casting method using different grades of HPMC (E5, 50 cps and K4M). Six formulations (FT1-FT6) of telmisartan films were prepared and evaluated for their physical characteristics such as thickness, tensile strength, percentage elongation, weight variation, folding endurance, drug content uniformity and surface pH and gave satisfactory results. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. The formulations were subjected to disintegration, in vitro drug release and pharmacodynamic studies on spontaneous hypertensive rats (SHR). Amongst the formulations of FT1-FT6, FT6 was found as best formulation which contains HPMC E5 and telmisartan solid dispersion with guar gum at weight ratio of 1:2 and showed excellent film forming characteristics such as disintegration time at 42 sec and percentage drug release 97.98% within 10 minutes. The optimized film formulation (FT6) showed excellent stability over 45 days when stored at 40°C/60% RH. The pharmacodynamic study in SHR proved that fast dissolving films of telmisartan produced a faster onset of action.
6
Dangre, Pankaj V., Ram D. Phad, Sanjay J. Surana, and Shailesh S. Chalikwar. "Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes." Advances in Polymer Technology 2019 (May 5, 2019): 1–13. http://dx.doi.org/10.1155/2019/3682402.
Full textAbstract:
The present work endeavors fabrication of fast dissolving buccal film of clonidine hydrochloride by employing quality by design (QbD) based approach. The total nine formulations were prepared according to formulation by design helped by JMP software 13.2.1. The patient oriented quality target product profiles were earmarked and on that basis critical quality attributes were identified. Preliminary screening studies along with initial risk assessment eased the selection of film-forming polymer (HPMC E 15) and plasticizer (PEG 400) as CMAs for formulation of films. A 32 full factorial plan was utilized for assurance of impact, i.e., HPMC E15 (X1) and PEG 400 (X2), as independent variables (factors) on thickness (mm) (Y1), disintegration time (s) (Y2), folding endurance (Y3), and tensile strength (kg) (Y4). Furthermore, prediction profiler assists in predicting composition of best formulation encompassing desired targeted response. The optimized formulation (F6) showed fast drug dissolution (>90%) within 8 min, and solid state characterization by DSC, XRD revealed excellent film characteristics. In a nutshell, the fast dissolving buccal film for clonidine hydrochloride was successfully developed assisted by QbD approach with markedly improved biopharmaceutical performance as well as patient compliance.
7
Surini, Silvia, Fungi Gotalia, and Kurnia Sari Setio Putri. "FORMULATION OF MUCOADHESIVE BUCCAL FILMS USING PREGELATINIZED CASSAVA STARCH PHTHALATE AS A FILM-FORMING POLYMER." International Journal of Applied Pharmaceutics 10, no. 1 (December 20, 2018): 225. http://dx.doi.org/10.22159/ijap.2018.v10s1.50.
Full textAbstract:
Objective: This study aimed to compare the characteristics of four buccal films formulated with phthalylated cassava starch and their drug deliverypotentials.Methods: An alternative to conventional (oral) drug administration is to administer drugs in a buccal film; however, the required dosage mustbe dissolved in a film-forming polymer with suitable mechanical and mucoadhesive characteristics. Previous studies have produced excipientsby physically and chemically modifying starch, such as by completely pregelatinization and phthalylation it in an aqueous medium under alkalineconditions (pH 8–10). This produced a pregelatinized cassava starch phthalate (PCSPh) powder with a high degree of substitution (0.0541±0.0019),thus giving it different physical, chemical, and functional characteristics than unphthalated PCS.Results: PCSPh in 4.5% and 6% (w/w) concentrations was used as excipients for producing four formulations of buccal film. One film had themost suitable characteristics, with an ex vivo mucoadhesion time of 57.1±20.3 min, tensile strength of 0.84±0.02 N/mm2, and a more rapid drugrelease profile than two of the other film types produced. Our tests also revealed that the best film tended to not change physically when moistened(percentage moisture absorption was 139% and moisture loss was 65%).Conclusion: Thus, we predict that PCSPh could be adequately formulated to provide mucoadhesive buccal films with an appropriate drug release profile.
8
Jamal Mohamed A, Perinbam K, Vahitha V, Devanesan S, and Janakiraman K K. "Povidone iodine loaded film-forming topical gel and evaluation of its chemical stability." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (January 7, 2020): 148–53. http://dx.doi.org/10.26452/ijrps.v11i1.1799.
Full textAbstract:
The main aim of this study was to develop Povidone Iodine loaded film-forming gel for excellent wound healing property with various formulations, and corresponding application stratification was prepared with Povidone Iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey. Povidone Iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds. Among the antiseptic and antimicrobial substances, Povidone-Iodine still occupies its position of lasting importance in everyday human and veterinary medicine. Povidone-iodine products display the broadest spectrum of antimicrobial effect with high clinical efficacy together with extremely low toxicity in clinical practice. The purpose served by dressing includes protecting wounds, promoting healing, and providing, retaining, or removing moisture. Wound repairing is a complex process involving an integrated response by many different cell types and growth factors to achieve rapid restoration of skin integrity and protective function after injury. In recent years, there have been tremendous advances in the design and composition of bandages and dressings, and there are numerous wound care materials. Some wound dressing types are biosynthetic dressings, composite dressings, gauze, hydrocolloid dressings, hydrogels, transparent films, etc. Povidone Iodine is completely soluble in cold and mild-warm water, ethyl alcohol, Iso propyl alcohol, Polyethylene glycol, and glycerol. The developed Povidone Iodine loaded film-forming gel was evaluated for their physical and chemical stability. The film-forming optimized gel formulation composed of povidone-iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey and this composition provides suitable consistency, spreadability, and adhesiveness. The prepared trials were coded PGAH-01, PGAH-02, PGAH-03, PGAH-04, and PGAH-05, respectively. Among these all formulations, the PGAH-04 formulation parameters was found within the limit.
9
Kumar, Y. Shravan, R. Gowthami, Sujitha H, Nagaraju T, Rajashekar M, Murali Krishna Kumar, and Y. Madhusudhan Rao. "Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 2 (August 31, 2013): 2087–96. http://dx.doi.org/10.37285/ijpsn.2013.6.2.11.
Full textAbstract:
Sumatriptan succinate is a 5-HT1B/1D receptor agonist which has well established efficacy in treating migraine. The main objective of the study was to formulate Oral Fast Disintegrating Films (ODF) and Oral Fast Disintegrating Tablets (ODT) to achieve a better dissolution rate and further improving the bioavailability of the drug. ODFs were prepared by solvent casting method using film forming polymers like HPMC – E15,5cps,50cps in different ratios & prepared batches of films were evaluated for the drug content, film thickness, disintegration time and in vitro dissolution studies. Among the prepared formulation F7 containing HPMC – 50cps (drug: polymer ratios = 1:1) was found to be best formulations which releases 98.2±1.1of the drug within 17±0.02 sec. ODTs prepared by direct compression method using in different concentrations of super-disintegrants. The prepared formulation T12 (combination of disintegrants) containing CP + CCS (6%) was considered to be the best formulation, which releases up to 100±0.38% of the drug in 23±0.75 sec, respectively. Based on these results, it is suggested that ODFs have faster disintegration time and drug release than ODTs.
10
Kumar, Y. Shravan, Deepthi B, and Mounika M. "Formulation and Evaluation of Salbutamol Sulphate Sublingual Films." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 5 (September 30, 2017): 3836–43. http://dx.doi.org/10.37285/ijpsn.2017.10.5.4.
Full textAbstract:
Salbutamol is a short-acting, selective beta-2-adrenergic receptor agonist used in treatment of asthma and COPD. In the present work, sublingual films of Salbutamol sulphate were developed with a view to enhance the patient compliance and provide quick onset of action. Salbutamol has a bioavailability of 53 - 60%. The goal of the study was to formulate sublingual films of Salbutamol sulphate to achieve a better dissolution rate and further improving the bioavailability of the drug. Sublingual films prepared by solvent casting method using film forming polymers HPMC-E5, HPMC-E15 and Maltodextrin in different ratios. The prepared batches of films were evaluated for the drug content, weight variation, film thickness, disintegration time and in vitro dissolution studies. Among all, the formulation B1 containing HPMC-E15 with a drug: polymer ratio (1:6) was found to be the best formulation which showed 98.36% of the drug release within 15 minutes and disintegration time 18 sec. This study shows the viability of developing sublingual films of salbutamol.
11
Gupta, Ashutosh, Jatin Kumar, Surajpal Verma, and Harmanpreet Singh. "APPLICATION OF QUALITY BY DESIGN APPROACH FOR THE OPTIMIZATION OF ORODISPERSIBLE FILM FORMULATION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 14 (July 27, 2018): 8. http://dx.doi.org/10.22159/ajpcr.2018.v11s2.28508.
Full textAbstract:
Objective: The present study was done to understand the effect of formulation variables on the quality of orodispersible films using quality by design (QbD) approach as mentioned in ICH Q8 (R2) guideline.Methods: A definitive screening design of experiments (DoE) was used to identify and classify the critical formulation variables affecting critical quality attributes (CQA) using 2×2 factorial design. Based on prescreening study, the critical formulation variables, i.e. concentration of film-forming polymer and plasticizers (propylene glycol and polyethylene glycol 400 [PEG 400]) were kept in the range of 1.5–2.5% w/w and 0.5–1% v/v, respectively. A total of eight laboratory-scale formulations were prepared which were provided by DoE using solvent casting method. These batches were evaluated for CQA’s, i.e. mechanical properties such as folding endurance (FD) and disintegration time (DT). Data were analyzed for elucidating interactions between two variables and for providing a predictive model for the process. Finally, the drug was incorporated into optimized batches, and these were evaluated for in vitro dissolution study in simulated saliva (pH 6.8) as well as their mechanical properties.Results: The results suggested that the concentration of film-forming polymer and plasticizer was critical to manufacture orodispersible film with desired CQA, i.e. mechanical property (FD [>150 folds]) and DT (<60 s). The percent drug release, FD, and DT of optimized Formulation I (hydroxypropyl methylcellulose [HPMC] E5 (2%) and propylene glycol [0.15 mL]) were found to be 82.13%±0.260 (in 15 min), 164±2, and 49±1.5 s, respectively, and for optimized Formulation II (HPMC E5 [2%] and PEG 400 [0.15 mL]) was found to be 64.26%±2.026 (in 15 min) and 218±6 and 55±4 s, respectively.Conclusion: From the results, it has been found that the percentage drug release of naratriptan hydrochloride containing propylene glycol as a plasticizer was greater than the formulation containing PEG 400 as plasticizer. From this, we concluded that QbD is very much useful approach to get an optimized formulation in an economic and faster way in comparison to traditional method (hit and trail methods). The futuristic application of the film will involve the management of an acute migraine.
12
Kale, Rupali, Dattatray Doifode, and Pratiksha Shete. "Film Forming, Antimicrobial and Growth Promoting Wound Healing Spray Formulation." International Journal of Pharmaceutical Investigation 10, no. 3 (October 10, 2020): 320–25. http://dx.doi.org/10.5530/ijpi.2020.3.57.
Full text
13
Nagpal, Meenu, Geeta Aggarwal, Upendra Kumar Jain, and Jitender Madan. "OKRA FRUIT GUM-CHITOSAN IMPREGNATED POLYMER NETWORK FILMS: FORMULATION AND SUBSTANTIAL DEPICTION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (September 1, 2017): 219. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20362.
Full textAbstract:
Objective: The present research is aimed at formulation and evaluation of okra fruit gum (OFG)-chitosan (CH) impregnated polymer network films.Methods: The film forming property of the gum attained from fruits of Abelmoschus esculentus was enhanced by co-processing it with CH. Estimation of properties including swelling index (SI), film volume, volume index, film surface contact angle with buffer solutions (pH 1.2, 7.4 or 6.8), work of adhesion (Wa), and spreading coefficient was done.Results: The contact angle and SI of OFG-CH film in both acidic and alkaline buffers were witnessed to be lowest when equated with the films prepared with difference in ratios of both gum and CH. Moreover, the Wa and spreading coefficient were less for this film. These results could be attributed to the optimum interaction between –COO− groups of gum and -NH3+ groups of CH.Conclusion: The actual nature of the film found to be tough, flexible, and water resistant. Hence, the results have shown that the films produced have a high potential for use in modified drug release and in food and pharmaceuticals.
14
Socaciu, Maria-Ioana, Melinda Fogarasi, Cristina Anamaria Semeniuc, Sonia Ancuţa Socaci, Mihaela Ancuţa Rotar, Vlad Mureşan, Oana Lelia Pop, and Dan Cristian Vodnar. "Formulation and Characterization of Antimicrobial Edible Films Based on Whey Protein Isolate and Tarragon Essential Oil." Polymers 12, no. 8 (August 5, 2020): 1748. http://dx.doi.org/10.3390/polym12081748.
Full textAbstract:
The effects of heat treatment and the addition of tarragon essential oil on physical and mechanical properties of films prepared with 5% whey protein isolate (WPI) and 5% glycerol were investigated in this study. Heat treatment of the film-forming solution caused increases in thickness, moisture content, swelling degree, water vapor permeability (WVP), b*-value, ΔE*-value, transmittance values in the 200–300-nm region, transparency, and puncture resistance of the film, but decreases in water solubility, L*-value, a*-value, transmittance values in the 350–800-nm region, and puncture deformation. When incorporated with tarragon essential oil, heat-treated films have the potential to be used as antimicrobial food packaging. The addition of tarragon essential oil in film-forming solution caused increases in moisture content, solubility in water, WVP, a*-value, b*-value, ΔE*-value, and transparency of the film; decreases in transmittance values in the range of 600–800 nm; and variations in swelling degree, L*-value, transmittance values in the range of 300–550 nm, puncture resistance, and puncture deformation. Nevertheless, different tendencies were noticed in UNT (untreated) and HT (heat-treated) films with regards to transparency, light transmittance, puncture resistance, and puncture deformation. Based on these findings, HT films show improved physical and mechanical properties and, therefore, are more suitable for food-packaging applications.
15
Pawar, Rajat, Ravi Sharma, and Gajanan Darwhekar. "Formulation and Evaluation of Mouth Dissolving Film of Prochlorperazine Maleate." Journal of Drug Delivery and Therapeutics 9, no. 6 (November 15, 2019): 110–15. http://dx.doi.org/10.22270/jddt.v9i6.3679.
Full textAbstract:
This research work was aimed to enhance the oral bioavailability and provide faster onset of action of Prochlorperazine maleate (used for the treatment nausea and vomiting) by formulating its mouth dissolving film (MDF). Prochlorperazine belongs to BCS II and oral bioavailability of it’s about 11-15%. The MDF of Prochlorperazine maleate was prepared by solvent casting method using HPMC (film forming agent),Glycerol (plasticizer), Betacyclodextrin (solubilizing agent), Citric acid (saliva stimulating agent), Mannitol (sweetening agent). The formulation was optimized by two factors, three levels (32) was used for the formulation optimization of fast dissolving film of Prochlorperazine maleate and experimental trials are performed on all 9 formulation. In which the amount of HPMC, Glycerol were selected as independent variables (factor) varied at three different level: low (-1), medium (0), and high (+1) levels. The drug release and disintegration time used as dependent variables (response). and formulation was evaluated for weight variation, thickness, folding endurance, drug content, in- vitro disintegration, in vitro dissolution study and stability study. Based on results it was concluded that MDF (F3) showed enhanced bioavailability and faster onset of action.
Keywords: Prochlorperazine maleate, Mouth dissolving film, bioavailability
16
P, Sanjay, Vishal Gupta N, Gowda Dv, and Praveen Sivadasu. "FORMULATION AND EVALUATION OF ORAL DISINTEGRATING FILM OF ATENOLOL." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (August 7, 2018): 312. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26464.
Full textAbstract:
Objective: The main objective of the study was to formulate the oral disintegrating films loaded with atenolol by solvent-casting method and to carry out its evaluation studies.Methods: The films were prepared using the film-forming hydrophilic polymer like hydroxypropyl methylcellulose (E-5) and super disintegrant like pectin in various proportions.The formulated oral films were characterized for Fourier transform infrared (FTIR) and morphological evaluations. Various physicochemical parameters such as weight variation, folding endurance, surface pH, in vitro disintegration, and in vitro dissolution studies were carried out.Results: FTIR studies revealed that there was no drug-polymer interaction. The morphological evaluation of films showed that all the films were homogenous and transparent. The folding endurance test ensured that the films had sufficient brittleness and by weight variation test, it was inferred that all the films were within the deviation. The surface pH study showed the pH of the films was around neutral pH. The drug was well distributed in all the films. The films disintegrated within 120 s and the fastest being disintegrated in 30 s. Based on all the evaluation parameters, F6 had shown optimal performance and remarkable increase in drug release of 94.38% in 2 min.Conclusion: Thus, formulated oral disintegrating films can be termed as an alternative approach to deliver atenolol.
17
Bajaj, Himani, Vinod Singh, Ranjit Singh, and Tirath Kumar. "FABRICATION AND EVALUATION OF CHITOSAN-BASED FILM FORMING GEL OF ACECLOFENAC FOR TRANSDERMAL DRUG DELIVERY." INDIAN DRUGS 58, no. 06 (August 17, 2021): 68–70. http://dx.doi.org/10.53879/id.58.06.12758.
Full textAbstract:
The objective of the present study was to prepare a topical film-forming gel of aceclofenac for the treatment of rheumatic diseases, using a safe and effective drug delivery approach. Aceclofenac film-forming gels were prepared using hydroxypropyl methyl cellulose and chitosan polymeric blend in varying concentrations, polyethylene glycol 400 (PEG 400) as a plasticizer, Tween 80 as a permeation enhancer and ethanol as solvent. The prepared film-forming gels were evaluated and the influence of the concentration and ratio of polymeric blends, plasticizer, and ethanol used were investigated. All the prepared film-forming gels showed satisfactory properties regarding consistency, spreadability and thickness. Variation in the concentration of polymers, ethanol and PEG 400 showed a variable effect on drying time from film-forming gels. Film-forming gels of aceclofenac were successfully developed and may provide a promising effective formulation that may improve patient compliance.
18
Ahmed, Jwan, Dina Boya, and Hunar Kamal. "Formulation of a fast-dissolving oral film using gelatin and sodium carboxymethyl cellulose." Zanco Journal of Medical Sciences 24, no. 3 (December 25, 2020): 338–46. http://dx.doi.org/10.15218/zjms.2020.040.
Full textAbstract:
Background and objective: Orally disintegrating film is a solid dosage form made as an alternative for tablets for pediatric and geriatric patients who have difficulty in swallowing. These formulations are designed to dissolve in the mouth rapidly upon contact with saliva. This study aimed to prepare a thin oro-dispersible film base that can withstand handling in which a drug can be incorporated to provide a new dosage form. Methods: The solvent casting method was used to prepare the films, in which the ingredients were mixed, dissolved, and cast in a Petri dish. Then, they were left to dry in the oven overnight. Different concentrations of each of the two polymers alone and combined in different ratios were compared using different concentrations of plasticizer. Results: Successful, transparent films were prepared from gelatin and glycerin. A combination of 70% gelatin and 30% sodium carboxymethyl cellulose with glycerin formed an acceptable film having white color. The film forming capacity of sodium carboxymethyl cellulose alone was not good. All films were tearing and not well formed. All films that contain polyethylene glycol were brittle. Both superdisintegrants reduced the disintegration time for both films, but kyron was more effective than sodium starch glycolate. Conclusion: A successful oral film was prepared using different types of polymers, which is suitable for incorporating a potent drug to form a new dosage form that is easily portable and does not require water for swallowing. Keywords: Fast dissolving oral film; Gelatin; Sodium carboxy methyl cellulose; Solvent casting method.
19
Yang, Qingliang, Feng Yuan, Lei Xu, Qinying Yan, Yan Yang, Danjun Wu, Fangyuan Guo, and Gensheng Yang. "An Update of Moisture Barrier Coating for Drug Delivery." Pharmaceutics 11, no. 9 (September 1, 2019): 436. http://dx.doi.org/10.3390/pharmaceutics11090436.
Full textAbstract:
Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings.
20
Saudagar, R. B., and S. Samuel. "Formulation Development and Evaluation of Topical Film-Forming Lotion Containing Butenafine Hydrochloride." Asian Journal of Pharmacy and Technology 6, no. 4 (2016): 238. http://dx.doi.org/10.5958/2231-5713.2016.00035.0.
Full text
21
McDonough, Carrie A., Chastity Ward, Qing Hu, Samuel Vance, Christopher P. Higgins, and Jamie C. DeWitt. "Immunotoxicity of an Electrochemically Fluorinated Aqueous Film-Forming Foam." Toxicological Sciences 178, no. 1 (September 8, 2020): 104–14. http://dx.doi.org/10.1093/toxsci/kfaa138.
Full textAbstract:
Abstract Aqueous film-forming foams (AFFFs) are complex per- and polyfluoroalkyl substance (PFAS)-containing mixtures used extensively as fire suppressants. AFFF-impacted groundwater and surface water have contaminated drinking water with PFASs in many communities, raising concerns about health effects from drinking water exposures. As individual PFASs have been identified as immune hazards, the immunotoxicity of complex PFAS mixtures is also a concern. Adult female and male C57BL/6 mice were given a commercial AFFF formulation for 10 days via gavage; administered dose was based on combined content of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) measured in the formulation (0, 1.88, 3.75, 7.5, or 10 mg PFOS+PFOA/kg body weight). A PFOA positive control of 7.5 mg/kg body weight was also given. Compared with the 0 mg/kg group, the following changes were noted: Body weights of males exposed to 7.5 and 10 mg PFOS+PFOA/kg were reduced by 15%, on average; female body weights did not differ. Average relative liver weights were increased 50%–200% in males and 37.5%–193% in females and liver peroxisome proliferation was increased 2- to 12-fold in all doses of both sexes. Antigen-specific antibody production was suppressed, on average, by 13% in males and by 12.4% in females across all doses. Spleen cellularity and lymphocyte subpopulations did not differ by dose for either sex. Our data indicate that though this complex PFAS mixture contained fairly low PFOA content, it induced changes in C57BL/6 mice similar to changes induced by PFOA alone, likely due to the presence of PFOS and many other PFASs.
22
Cirule, Dace, Errj Sansonetti, Ingeborga Andersone, Edgars Kuka, and Bruno Andersons. "Enhancing Thermally Modified Wood Stability against Discoloration." Coatings 11, no. 1 (January 13, 2021): 81. http://dx.doi.org/10.3390/coatings11010081.
Full textAbstract:
Thermal modification of wood has gained its niche in the production of materials that are mainly used for outdoor applications, where the stability of aesthetic appearances is very important. In the present research, spectral sensitivity to discoloration of thermally modified (TM) aspen wood was assessed and, based on these results, the possibility to delay discoloration due to weathering by non-film forming coating containing transparent iron oxides in the formulation was studied. The effect of including organic light stabilizers (UVA and HALS) in coatings as well as pretreatment with lignin stabilizer (HALS) was evaluated. Artificial and outdoor weathering was used for testing the efficiency of different coating formulations on TM wood discoloration. For color measurements and discoloration assessment, the CIELAB color model was used. Significant differences between the spectral sensitivity of unmodified and TM wood was observed by implying that different strategies could be effective for their photostabilization. From the studied concepts, the inclusion of the transparent red iron oxide into the base formulation of the non-film forming coating was found to be the most effective approach for enhancing TM wood photostability against discoloration due to weathering.
23
Kim, Yujin, Moritz Beck-Broichsitter, and Ajay Banga. "Design and Evaluation of a Poly(Lactide-co-Glycolide)-Based In Situ Film-Forming System for Topical Delivery of Trolamine Salicylate." Pharmaceutics 11, no. 8 (August 12, 2019): 409. http://dx.doi.org/10.3390/pharmaceutics11080409.
Full textAbstract:
Trolamine salicylate (TS) is a topical anti-inflammatory analgesic used to treat small joint pain. The topical route is preferred over the oral one owing to gastrointestinal side effects. In this study, a poly(lactide-co-glycolide) (PLGA)-based in situ bio-adhesive film-forming system for the transdermal delivery of TS was designed and evaluated. Therefore, varying amounts (0%, 5%, 10%, 20%, and 25% (w/w)) of PLGA (EXPANSORB® DLG 50-2A, 50-5A, 50-8A, and 75-5A), ethyl 2-cyanoacrylate, poly (ethylene glycol) 400, and 1% of TS were dissolved together in acetone to form the bio-adhesive polymeric solution. In vitro drug permeation studies were performed on a vertical Franz diffusion cell and dermatomed porcine ear skin to evaluate the distinct formulations. The bio-adhesive polymeric solutions were prepared successfully and formed a thin film upon application in situ. A significantly higher amount of TS was delivered from a formulation containing 20% PLGA (45 ± 4 µg/cm2) and compared to PLGA-free counterpart (0.6 ± 0.2 µg/cm2). Furthermore, the addition of PLGA to the polymer film facilitated an early onset of TS delivery across dermatomed porcine skin. The optimized formulation also enhanced the delivery of TS into and across the skin.
24
Sadeq, Zainab Ahmed, and Nawal Ayash Rajab. "STUDYING THE EFFECT OF DIFFERENT VARIABLES ON THE FORMULATION OF MUCOADHESIVE BUCCAL PATCHES OF CAPTOPRIL." International Journal of Applied Pharmaceutics 9, no. 2 (March 10, 2017): 16. http://dx.doi.org/10.22159/ijap.2017v9i2.16345.
Full textAbstract:
Objective: The objective of this research was to formulate the captopril as mucoadhesive buccal films for hypertension treatment and studying the effect of different variables on the physical and mechanical behavior of the prepared films.Methods: The bucco-adhesive patches were prepared using hydroxyl propyl methyl cellulose K4 (HPMC) as film forming a polymer with secondary polymer included carbopol 934 and eudragit RL100. The patches were prepared by a solvent casting method and evaluated for the weight variation, surface pH, mechanical properties, content, uniformity, ex-vivo mucoadhesive strength, ex-vivo permeation study and drug release study.Results: Formula F5 containing HPMC as primary polymer with carbopol 934 as secondary polymer was chosen to be the best formulation for the following parameters: surface pH6.44, tensile strength (16.06), percentage elongation at break (34.14), swelling index(18.85), mucoadhesive strength(26.2 gm) and the folding endurance was>300 with an in vitro drug release about 94.73% during 6 h.Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetric studies (DSC) showed no interaction between the drug and polymers.Conclusion: It can be concluded that oral mucoadhesive buccal film of captopril, an antihypertensive agent can be prepared utilizing HPMC as a film forming a polymer with carbopol as a secondary polymer which extended the drug release through the buccal mucosa for 6 h.
25
Yadav, Chandrajeet Kumar, Manish Karn, Pinki Yadav, and Roshan Mehta. "Formulation, Optimization and In-vitro Evaluation of Fast Dissolving Oral films of Metoclopramide Hydrochloride by Solvent Casting method." International Journal of PharmTech Research 13, no. 3 (2020): 229–41. http://dx.doi.org/10.20902/ijptr.2019.130314.
Full textAbstract:
The Present study aimed to prepare fast dissolving oral films (FDFs) of metoclopramide hydrochloride, because of its application in emesis condition where fast onset of action and avoidance of water is highly desirable. Moreover, this dosage form is highly useful in pediatrics, geriatrics and unconscious patients. FDFs were prepared by solvent casting technique with film forming polymers HPMC, PVA & Sodium alginate in varying concentrations with excipients like SLS as surfactant, Glycerol as plasticizer, citric acid as saliva stimulating agent, Sodium Saccharin as sweetening agent. The film of 2×3 cm was prepared by casting into a petridish of calculated size and dried in dryer at temperature 40˚c. The In-Vitro evaluation of characteristics like Film Thickness, Weight Variation, disintegration time, dissolution study, surface pH, content uniformity was studied. The best formulation was found to be F5 containing polymer PVA and Sodium alginate in the ratio 2:1, with disintegration time 24 seconds, and dissolution profile of 75% in 60 seconds and 90% in 90 seconds. The content uniformity of all the formulations was found to be within the limit (98-101%). The disintegration time of all the formulations was found to be below 30 seconds except F4 (26 sec.). Thus, fast dissolving Films of Metoclopramide hydrochloride can be successfully formulated and will be used as a novel drug dosage form for paediatric and geriatric with improved patient compliance and enhanced bioavailability.
26
Bala, Rajni, Sushil Khanna, and Pravin Pawar. "Design Optimization and In Vitro-In Vivo Evaluation of Orally Dissolving Strips of Clobazam." Journal of Drug Delivery 2014 (September 28, 2014): 1–15. http://dx.doi.org/10.1155/2014/392783.
Full textAbstract:
Clobazam orally dissolving strips were prepared by solvent casting method. A full 32 factorial design was applied for optimization using different concentration of film forming polymer and disintegrating agent as independent variable and disintegration time, % cumulative drug release, and tensile strength as dependent variable. In addition the prepared films were also evaluated for surface pH, folding endurance, and content uniformity. The optimized film formulation showing the maximum in vitro drug release, satisfactory in vitro disintegration time, and tensile strength was selected for bioavailability study and compared with a reference marketed product (frisium5 tablets) in rabbits. Formulation (F6) was selected by the Design-expert software which exhibited DT (24 sec), TS (2.85 N/cm2), and in vitro drug release (96.6%). Statistical evaluation revealed no significant difference between the bioavailability parameters of the test film (F6) and the reference product. The mean ratio values (test/reference) of Cmax (95.87%), tmax (71.42%), AUC0−t (98.125%), and AUC0−∞ (99.213%) indicated that the two formulae exhibited comparable plasma level-time profiles.
27
Carpenter, Garima, and R. K. Maheshwari. "Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation." Journal of Drug Delivery and Therapeutics 8, no. 6 (November 15, 2018): 132–41. http://dx.doi.org/10.22270/jddt.v8i6.2034.
Full textAbstract:
The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly soluble drug, furosemide was tried to be solubilized by employing the combination of physiologically compatible water-soluble additives (solubilizers) to formulate its fast dissolving formulations. For the development of fast dissolving oral film, firstly, different film forming polymers were tested for their film properties. The second fast dissolving layer was also formed and optimized. Solubility studies were conducted to select water-soluble additives for formulation of fast dissolving drug layer. Keeping the total concentration less than 40 % w/v of mixed blends, different aqueous blends were prepared employing solubilizers from among sodium benzoate, sodium acetate, sodium citrate, urea, niacinamide, glycerin, propylene glycol, polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600, and PVP K 30. Maximum solubility of furosemide was found in blends- F5 (10% sodium caprylate +2.5%sodium benzoate+ 2.5% niacinamide) and in blend F7 (10% sodium caprylate +2.5%sodium benzoate +2.5% sodium citrate + 2.5% niacinamide). Prepared films were evaluated for drug content, thickness, folding endurance, tensile strength and hydration ratio.
Keywords: Furosemide, fast dissolving oral film, mixed solvency concept.
28
Tamer, Manar Adnan, Shaimaa Nazar Abd-al Hammid, and Balqis Ahmed. "FORMULATION AND IN VITRO EVALUATION OF BROMOCRIPTINE MESYLATE AS FAST DISSOLVING ORAL FILM." International Journal of Applied Pharmaceutics 10, no. 1 (January 6, 2018): 7. http://dx.doi.org/10.22159/ijap.2018v10i1.22615.
Full textAbstract:
Objective: The aim of this study was to formulate and in vitro evaluate fast dissolving oral film of practically insoluble bromocriptine mesylate to enhance its solubility and to improve its oral bioavailability by avoiding first pass effect as well as to produce an immediate release action of the drug from the film for an efficient management of diabetes mellitus type II in addition to an improvement of the patient compliance to this patient-friendly dosage form.Methods: The films were prepared by the solvent casting method using hydroxypropyl methylcellulose of grades (E3, E5, E15), polyvinyl alcohol (PVA), pectin and gelatin as film-forming polymers in addition to polyethene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as a plasticizer. Poloxamer 407 was used as a surfactant, sodium saccharin as a sweetening agent, citric acid as a saliva stimulating agent, vanilla as a flavouring agent and crospovidone as a super disintegrant. The prepared films then tested for physical characterization, thickness, weight uniformity, mechanical characteristics (folding endurance, tensile strength, percent elongation and Young's modulus), surface pH, in vitro disintegration time, drug content and an in vitro drug release.Results: Films were found to be satisfactory when evaluated for physical characterization, thickness, weight uniformity, mechanical tests, in vitro disintegration time, folding endurance, drug content and an in vitro drug release. The surface pH of all the films was found to be neutral or minor change. Films in vitro drug release studies were also done using USP dissolution apparatus type II (paddle type). The in vitro drug release profile in the optimized formulation F14 was gave 86.8 % of drug released at 2 min. The optimized formulation F14 was also showed satisfactory pH (6.2±0.2), drug content (99.2±0.5%), the disintegration time of 9.2±0.1 seconds and the time needed for 80% of medication to be released (T80 %) was 1.35 minute.Conclusion: The bromocriptine mesylate fast dissolving oral film was formulated. The given film disintegrates within nine seconds which release the drug rapidly and gives an action.
29
Mohd Azharuddin, Theivendren Panner Selvam, Maya Sharma, and Jayesh Dwivedi. "Design development and evaluation of novel ophthalmic nano lipid in situ gel-forming solution using timolol hydrochloride." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (December 5, 2020): 6837–44. http://dx.doi.org/10.26452/ijrps.v11i4.3654.
Full textAbstract:
The present research work was aimed to design, develop and evaluate the nano lipid-based drug delivery system by incorporating timolol hydrochloride drug for ocular therapy and improve the release of the drug through the ocular route. Nanolipids in situ gels were prepared by film hydration method involving two steps. First nano lipids were formulated with the help of organic solvents, and then they were incorporated into a gel by using gelling agents. FTIR spectrum studies were carried out for drug and the formulations which reveal that there was no interaction between the drug and excipients used. The various formulations prepared were subjected for the different evaluation parameters, which showed good and effective results for visual appearance, pH, gelation study, viscosity and ocular irritation studies. It was further observed from this research work that formulation TF2 (HPMC K-15M 0.2%w/v and Carbopol 940 0.4%w/v) had a maximum entrapment efficiency of 97.30%, drug content of about 97.67% and drug release of about 84.29% for 10 hrs. Stability studies were carried out for TF2 formulation, and they found that they were stable throughout the study period. It was finally concluded from the present work that formulations prepared were more suitable and had good patient compliance compared to the eye drops.
30
Senthilkumar, K., and C. Vijaya. "Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management." Advances in Pharmaceutics 2015 (January 26, 2015): 1–11. http://dx.doi.org/10.1155/2015/702963.
Full textAbstract:
Etoricoxib is a potent, orally active, and highly selective COX-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. The present research was undertaken to develop mouth dissolving films of etoricoxib to have rapid onset of action. Mouth dissolving film (MDF) is a better alternate to oral disintegrating tablets due to its novelty, ease of use, and the consequent patient compliance. Solubility enhancement and taste masking of etoricoxib were the two challenges solved by formulating drug-inclusion complex with beta-cyclodextrin (BCD). MDF prepared by solvent casting etoricoxib-BCD complex along with HPMC as film forming polymer was found to possess desirable physicomechanical properties. In vitro release of etoricoxib from MDF in simulated salivary fluid and 0.1 N HCl was more than 95% within 2 minutes. Taste masking and in vivo disintegration were in acceptable range as assessed by human volunteers. Etoricoxib MDF was further characterized by differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy. The index of analgesia shown by etoricoxib MDF was comparable to that of immediate release tablets (100% activity within 40 minutes) in animal studies. Conclusively, the present study documents the development of a commercially viable formula for an MDF of etoricoxib with rapidity in pain management.
31
Pecora, Tiziana Maria Grazia, Barbara Ragazzo, Walter Bertin, Alessia Ragonese, Marco Mascagni, Paola Maffei, and Rosario Pignatello. "Rheological Behavior of a New Mucoadhesive Oral Formulation Based on Sodium Chondroitin Sulfate, Xyloglucan and Glycerol." Journal of Functional Biomaterials 12, no. 2 (April 28, 2021): 28. http://dx.doi.org/10.3390/jfb12020028.
Full textAbstract:
Background: The study aimed at assessing the mucoadhesive properties and the barrier effect of a formulation, labelled as AL2106, containing sodium chondroitin sulfate (ChS), xyloglucan from tamarind seed extract, and glycerol, by evaluating the capacity to adhere to a layer of mucin, the rheological synergism and the barrier effect in comparison to the marketed Esoxx One medical device. AL2106 is a medical device distributed by Alfasigma SpA, Italy with REF FTP57 (Manufacturer: Labomar SpA); it is analogous to Esoxx One medical device: the two products are drinkable solutions that, after swallowing, adhere to the esophageal mucosa, protecting it from the corrosive effect of the gastric acid reflux. AL2106 has been conceived to be better performing in terms of duration of the barrier effect compared to Esoxx One. Methods: The mucoadhesive properties, rheological behavior, buffering capacity against acidity, and film-forming ability with the resultant protecting effect on esophagus mucosa (caffeine permeation test) was compared between the two products. Results: The mucoadhesivity of the formulations was shown in vitro: both remained adherent to a mucin layer, also when the support was rotated by 90°, and when the film layer was washed with water, intended to simulate the washout due to swallowing. AL2106 showed a good buffering efficacy, being able to absorb at least 50% of its weight of 0.03 M HCl while maintaining the pH above 4. The film-forming effect and barrier properties of AL2106 and Esoxx One were confirmed by an in vitro study on reconstructed human esophageal epithelium. A greater film-forming efficacy of AL2106, lasting for at least 5 h, than Esoxx One was observed. Noteworthy, the barrier function of esophageal tissues was shown to be preserved after the application of both formulations. Conclusions: The combination of ChS with the mucoadhesive glycerol−xyloglucan complex and other excipients, which contribute to the barrier effect and to mucoadhesion, contained in AL2106, allowed a longer-lasting protective effect than Esoxx One, proving its effectivity and safety for oral use.
32
Zarandona, Iratxe, Mónica Estupiñán, Carla Pérez, Laura Alonso-Sáez, Pedro Guerrero, and Koro de la Caba. "Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp." Marine Drugs 18, no. 9 (August 27, 2020): 447. http://dx.doi.org/10.3390/md18090447.
Full textAbstract:
Two Alteromonas sp. strains isolated from deep seawater were grown to promote the production of exopolysaccharides (EPS, E611 and E805), which were incorporated into chitosan solutions to develop films. The combination of the major marine polysaccharides (chitosan and the isolated bacterial EPS) resulted in the formation of homogenous, transparent, colorless films, suggesting good compatibility between the two components of the film-forming formulation. With regards to optical properties, the films showed low values of gloss, in the range of 5–10 GU, indicating the formation of non-glossy and rough surfaces. In addition to the film surface, both showed hydrophobic character, with water contact angles higher than 100 º, regardless of EPS addition. Among the two EPS under analysis, chitosan films with E805 showed better mechanical performance, leading to resistant, flexible, easy to handle films.
33
Meteleva, Olga V., and Ludmila I. Bondarenko. "Optimization of Film Composite Functional Properties for Sewing Products." Key Engineering Materials 869 (October 2020): 382–87. http://dx.doi.org/10.4028/www.scientific.net/kem.869.382.
Full textAbstract:
The process technological parameters of forming a film composite for making heat-protective clothing have been developed. The peculiarities of its application in sewing production are taken into account. The effect of the initial polymer compositions formulation on the formed composites physical-mechanical and technological properties was studied. It has been found that the use of the composite film material developed reduces the compounds permeability of protective clothing.
34
Qin, Jing, and Ni Yin. "Tobramycin Collagen Fast Dissolving Ocular Films for Corneal Tissue Engineering of Keratoconus." Journal of Biomaterials and Tissue Engineering 9, no. 6 (June 1, 2019): 804–9. http://dx.doi.org/10.1166/jbt.2019.2051.
Full textAbstract:
Fast dissolving films are a one of novel dosage form in pharmaceutical research. They have convenience and ease of use over other dosage forms such as orally disintegrating tablets and immediate release tablets. In the present research, rapidly dissolving films of Tobramycin were developed using Polyvinyl acetate (PVA) and polyvinyl pyrollidone (PVP) as film forming polymers by solvent casting method. The prepared films were evaluated for drug content, weight variation, thickness and in vitro in vivo disintegration time. The in vitroand in vivodissolving time of the optimized formulation was found to be below 15–40 seconds respectively. The prepared films exhibited good integrity and thickness. In vitro dissolution studies were performed as per the FDA dissolution guidelines for about 3 minutes, the optimum formulation released complete drug within 3 minutes. Statistical analysis showed no drug polymer interaction.
35
Yi Sul, Chin, Ana Lucia Morocho-Jacomel, Fabiana Vieira Lima, Gabriela Argollo Marques, Wendi Lucia Avila Rodriguez, Claudia Alejandra Cruz Julcal, Esther del Rocio Abanto Robles, Catarina Rosado, Maria Valeria Robles Velasco, and Andre Rolim Baby. "In vitro water resistance evaluation of a bioactive sunscreen containing distinct film/ barrier-forming agents." Biomedical and Biopharmaceutical Research Journal 17, no. 2 (October 2020): 1–14. http://dx.doi.org/10.19277/bbr.17.2.241.
Full textAbstract:
The use of functional bioactive ingredients and the property of water resistance are differentials in the choice of more effective and safer sunscreens. Water-resistance tests are expensive, time-consuming, and usually performed on subjects that expose them to irradiation and long immersion times. Thus, the study of in vitro water resistance using different film/ barrier-forming agents is relevant for obtaining sunscreen resistant to rinsing. We aimed to evaluate the water resistance of a rutin-based bioactive sunscreen containing distinct film/barrier-forming agents by an in vitro method. The in vitro water resistance assessment (% WRR) was carried out in a water bath. In vitro sun protection factor (SPF), critical A, (nm), UVA/UVB ratio, and UVA protection factor (UVA-PF(0)) were evaluated before and after rinsing using a diffuse reflectance spectrophotometer with integration sphere. The formulation with dimethicone showed higher values of SPF after rinsing and achieved the requirement of % WRR greater than 50%. All formulations showed similar variations for all other parameters. The results highlighted the property of water resistance provided by the dimethicone, indicating that this emollient is an interesting ingredient choice for sunscreens.
36
Nabil Abdullah and Amit B Patil. "Application of DoE in polymers screening and optimization of in situ topical ϑilm-forming solution for spray formulation." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (December 21, 2020): 2499–515. http://dx.doi.org/10.26452/ijrps.v11ispl4.4505.
Full textAbstract:
DoE is a structured and organised method to determine the relationship between the effect of change in the concentration of the independent variables and its impact on the formulation, through establishing a mathematical model. Since the acceptance of the QbD approach by the regulatory authorities across the world, DoE has been widely implemented in the areas of screening and optimisation of the formulations by the pharmaceutical industries. The topical delivery of API still posses' limitations such as insufficient contact time, odd hours of application time, sticking to fabrics, formulation washing off, etc. To address these limitations, the researcher planned to develop an in situ polymeric sprays that will form a transparent and flexible film, & will not interfere with the applicant's routine. Polymers such as HPMC, Eudragit RS100, PVP K30, PVP K90, Carbopol, Propylene glycol, Soluplus, and pullulan whereas the plasticisers selected were sorbitol. Voriconazole, a second-generation triazole, was used as a model drug. The article is a technological demonstration, in which the screening of polymers as well as the optimised concentration of the polymeric will be selected through 32 factorial design. The aim of the present article is also to establish the relationship between the software response and experimental values. The experiments were designed using 32 factorial design which resulted in 9 trial runs. Each run was evaluated for drying time, viscosity, and stickiness. The resultant response surface Later the optimisation, to yield an optimised polymeric solution that can deliver a desired in situ films. Based on ANOVA comparison of variability due to treatment, the significance of the regression model was evaluated. Other procedures such as DSC, FRIR, Stickiness, pH, diffusion studies were also performed on the selected formulation.
37
Vangara, Kiran Kumar, Kishore K. Konda, Shiva K. Ravula, Pradeep K. Vuppala, Vijay K. Sripuram, and Sushma Samala. "Formulation Development of Metoprolol Succinate Controlled Release Tablets using Ethyl-cellulose-polyvinyl-pyrrolidone Coating." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (May 31, 2015): 2851–57. http://dx.doi.org/10.37285/ijpsn.2015.8.2.8.
Full textAbstract:
It is challenging to develop a controlled release (CR) formulation for a freely water soluble drug molecule without using rate controlling polymers in the core matrix. This study is aimed to develop and evaluate cost-effective ethyl cellulose (EC)-polyvinyl pyrrolidone (PVP) film coating that can effectively control the release of freely water soluble drug, metoprolol succinate (MS) and to match that of release profile with its marketed tablet. Simple core tables of MS were compressed and coated with a solution composed of hydrophobic rate controlling polymer, EC and water soluble pore forming polymer, PVP. The effect of formulation parameters such as the ratio of EC to PVP and tablet coating weight gain on the in-vitro drug release were evaluated. Release profile of the optimized formulation at different pH conditions was determined and the similarity factor (f2) with marketed release profile was calculated.It was observed that drug release rate increased with a decrease in the ratio of ethyl cellulose to PVP and decreased with increased weight gain of the coating membrane. Among all the formulations, the formulation with EC and PVP at a ratio of 60:40 %w/w and 9% weight gain showed matching release profile to marketed tablet with f2 value of 72.25. The optimized formulation showed pH independent in-vitro release. This study successfully demonstrated that EC-PVP film coating can effectively control the release rate of freely soluble drugs. Once a day CR formulation of metoprolol succinate pharmaceutically equivalent to marketed tablet was developed.
38
Jabir, Saba Abdulhadee, and Halah Talal Sulaiman. "PREPARATION AND CHARACTERIZATION OF LAFUTIDINE AS IMMEDIATE RELEASE ORAL STRIP USING DIFFERENT TYPE OF WATER-SOLUBLE POLYMER." International Journal of Applied Pharmaceutics 10, no. 5 (September 8, 2018): 249. http://dx.doi.org/10.22159/ijap.2018v10i5.28292.
Full textAbstract:
Objective: The objective of the present study was to design and optimize oral fast dissolving film (OFDF) of practically insoluble drug lafutidine in order to enhance bioavailability and patient compliance especially for a geriatric and unconscious patient who are suffering from difficulty in swallowing.Methods: The films were prepared by a solvent casting method using low-grade hydroxyl propyl methyl cellulose (HPMC E5), polyvinyl alcohol (PVA), and sodium carboxymethyl cellulose (SCMC) as film forming polymers. Polyethylene glycol 400 (PEG400), propylene glycol (PG) and glycerin were used as a plasticizer to enhance the film forming properties of the polymer. Tween 80 (1% solution) and poloxamer407 were used as a surfactant, citric acid as a saliva stimulating agent, and croscarmellose as a super disintegrant. Films were then tested for both physical (weight variation, thickness, surface pH, drug content) and mechanical (folding endurance, tensile strength, percent elongation, Young's modulus) characteristics. In vitro disintegration, time and drug release profile were also determined for each formula.Results: Films were found to be satisfactory when evaluated for both physical and mechanical characterizations. The surface pH of all the films was found to be within the range of salivary pH 6.8. The USP dissolution apparatus type II (paddle type) was used for in vitro drug release studies. The optimized formulation F13 gave 100 % of drug released at 2 min. It also showed satisfactory surface pH (6.2±0.2), drug content (100.1±0.01%), the disintegration time of (7.0±0.5) seconds and the time needed for 80% of medication to be released (T80%) was 0.96 min.Conclusion: Lafutidine OFDF was formulated using HPMC E5 as film-forming a polymer with PEG400 as a plasticizer. Combination of tween80 (1% solution) and poloxamer407 as a surfactant were used in the presence of croscarmellose as a super disintegrant. The chosen OFDF disintegrates within seven seconds, releases the drug rapidly and gives an action.
39
Phaechamud, T., and Juree Charoenteeraboon. "Rapidly Dried Antimicrobial Spray for Foot Deodorant." Advanced Materials Research 506 (April 2012): 473–76. http://dx.doi.org/10.4028/www.scientific.net/amr.506.473.
Full textAbstract:
This paper aimed to develop a physiologically activated dried antimicrobial spray for foot deodorant and select the suitable components such as film forming agent, solvent, antimicrobial agent and flavoring agents. The evaporation rates, antimicrobial activity, spray pattern, viscosity and cooling effect were evaluated. The developed formulation exhibited the high evaporating rate, high antimicrobial activity, appropriate spray pattern, slightly viscous solution with cooling effect after spraying onto skin. The developed formulation exhibited the potential application as the rapidly dried antimicrobial spray for foot deodorant.
40
Abbas, Ishraq K., Nawal A. Rajab, and Ahmed A. Hussein. "Formulation and In-Vitro Evaluation of Darifenacin Hydrobromide as Buccal Films." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 2 (December 22, 2019): 83–94. http://dx.doi.org/10.31351/vol28iss2pp83-94.
Full textAbstract:
Darifenacin hydrobromide (DH) is the more recent uroselective M3 receptor antagonist for treating uncomplicated overactive bladder (OAB). This study was aimed to formulate DH as fast dissolving buccal films (FDBFs) using a solvent casting method to enhance patient’s compliance.
Films were prepared by using polyvinyl alcohol (PVA) as a film forming polymer. Different types and concentrations of superdisintegrants (croscarmellose sodium, sodium starch glycolate, indion 414) were used to select the best formula by studying the physicochemical properties of the films, disintegration time (DT) and percent drug release.
The results revealed that formula (F9) that containing 7.5mg DH, 2%w/v PVA, 30%w/w glycerol, 0.5%w/v tween 80, 4%w/w indion 414 was the preferred formula. F9 showed the shortest in-vitro disintegration time (31.28sec). In-vitro dissolution profile showed the lowest T80% of the drug in 3.05 min and the highest release of the drug (94%) within 5 min (D5min %).
It was concluded that the FDBFs of DH could be considered as a promising drug delivery system with an enhanced disintegration and dissolution rate and better patient compliance.
41
Weng, Verónica, Carla Brazinha, Isabel M. Coelhoso, and Vitor D. Alves. "Decolorization of a Corn Fiber Arabinoxylan Extract and Formulation of Biodegradable Films for Food Packaging." Membranes 11, no. 5 (April 28, 2021): 321. http://dx.doi.org/10.3390/membranes11050321.
Full textAbstract:
Corn fiber from the corn starch industry is a by-product produced in large quantity that is mainly used in animal feed formulations, though it is still rich in valuable components, such as arabinoxylans, with proven film-forming ability. During arabinoxylans’ recovery under alkaline extraction, a dark-colored biopolymer fraction is obtained. In this work, a purified arabinoxylan extract from corn fiber with an intense brownish color was decolorized using hydrogen peroxide as the decolorizing agent. Biodegradable films prepared by casting the decolorized extract exhibited a light-yellow color, considered more appealing, envisaging their application in food packaging. Films were prepared with glycerol as plasticizer and citric acid as cross-linker. Although the cross-linking reaction was not effective, films presented antioxidant activity, a water vapor permeability similar to that of non-decolorized films, and other polysaccharides’ and mechanical properties that enable their application as packaging materials of low-water-content food products.
42
Saudagar, R. B., and P. A. Gangurde. "Formulation, development and evaluation of film-forming gel for prolonged dermal delivery of miconaole nitrate." Research Journal of Topical and Cosmetic Sciences 8, no. 1 (2017): 19. http://dx.doi.org/10.5958/2321-5844.2017.00003.6.
Full text
43
Oh, Dong-Won, Ji-Hyun Kang, Hyo-Jung Lee, Sang-Duk Han, Min-Hyung Kang, Yie-Hyuk Kwon, Joon-Ho Jun, et al. "Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen." Drug Delivery 24, no. 1 (January 1, 2017): 1056–66. http://dx.doi.org/10.1080/10717544.2017.1346001.
Full text
44
Ногина, Анна, Anna Nogina, Сергей Тихонов, Sergey Tikhonov, Наталья Тихонова, and Nataliya Tikhonova. "The Influence of Biodegradable Food Films on Freshness Indices of Semi-Finished Meat Products." Food Processing: Techniques and Technology 48, no. 4 (February 13, 2019): 73–78. http://dx.doi.org/10.21603/2074-9414-2018-4-73-78.
Full textAbstract:
Barrier storage technologies are a promising means of increasing the shelf life of meat products, in particular, food wrap. The authors developed an edible food film with antioxidant and antibacterial properties and tested its efficiency in storage of semi-finished meat products. The formula includes nutrients available for industrial production: structure-forming polysaccharide nature-agar-agar, thickener, stabilizer, antioxidant-arabinogalactan, plasticizer-food glycerin, and universal solvent-distilled water. The food film was produced by extrusion dosing of bulk components and distilled water. Then suspended mixture of agar-agar and arabinogalactan was prepared, followed by preparation of film-forming mixture. The film was blown through a narrow slit head of the extruder; after that it was cooled, calibrated, and dried. The films appeared to have a thickness that varied from 28.5 to 54.0 microns, depending on the concentration of the basic prescription components. The thickest film (54 µm) was observed in the sample with the maximum agar content (2%); an increase in the concentration of arabinogalactan in the film solution contributes to the film thickening to a lesser extent (47.1 µm). An increase in the glycerol content of the film formulation to 2% allowed the authors to obtain a film with a minimum thickness (28.5 microns). An increase in agar concentration raises the tensile strength to 36.2 MPa and elongation at break to 29.2%. However, with an increase in glycerol content, these indicators deteriorate to 25.3 MPa (24.6%). High structural and mechanical properties of the film and a high degree of decomposition were observed in the film sample with 2% agar-agar content. As an antimicrobial component, a liquid extract of chamomile flowers was introduced into the film. On the basis of the conducted organoleptic, physico-chemical, and microbiological studies, packaging of semi-finished meat products in a biodegradable film helps to increase their shelf life.
45
Pamlényi, Krisztián, Katalin Kristó, Orsolya Jójárt-Laczkovich, and Géza Regdon. "Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride." Pharmaceutics 13, no. 5 (April 26, 2021): 619. http://dx.doi.org/10.3390/pharmaceutics13050619.
Full textAbstract:
Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.
46
Biswas, EH, MA Islam, R. Ferdowsi, YA Yusof, and MG Aziz. "Effect of sugar and starch on chemical and organoleptic parameters of pineapple bar during storage." Progressive Agriculture 30, no. 2 (August 18, 2019): 227–37. http://dx.doi.org/10.3329/pa.v30i2.42519.
Full textAbstract:
The aim of this study was to assess the effect of major ingredients on the changes of fundamental quality parameters of pineapple fruit bar during preparation and storage. Four samples were prepared by using Extreme Vertex mixture taking three major ingredients namely fruit pulp, sugar and starch content as factors and non-enzymatic browning data and overall acceptability as responses. The result revealed that compositional differences of different ingredients in formulation fitted to the quadratic linear model at p<0.05. Among the four formulations the liking intensity of formulation F4 containing pineapple pulp 86%, starch 2% and sugar 12% showed the highest scores in all of the studied sensory parameters followed by F2, F3 and F1. Among the components studied, sugars irrespective of sources are the main components responsible for non-enzymatic browning whereas starch contributes to retain color by forming a protecting film around the reducing groups.
Progressive Agriculture 30 (2): 227-237, 2019
47
Wang, Shiying, Yi Zhang, Liupeng Yang, Qizhan Zhu, Qianli Ma, Ruifei Wang, Chaoqun Zhang, and Zhixiang Zhang. "Indoxacarb-Loaded Anionic Polyurethane Blend with Sodium Alginate Improves pH Sensitivity and Ecological Security for Potential Application in Agriculture." Polymers 12, no. 5 (May 15, 2020): 1135. http://dx.doi.org/10.3390/polym12051135.
Full textAbstract:
Traditional pesticide formulations show poor utilization and environmental safety due to their low foliage adhesion and large auxiliaries. In this study, a novel and environment-friendly indoxacarb formulation was prepared to improve the pesticide’s utilization rate, target control characteristics and ecological security. Indoxacarb-loaded waterborne polyurethane–sodium alginate (PU/SA) nanoemulsions with film forming properties, alkaline responsive release, high effectiveness against Spodoptera litura, and reduced acute contact toxicity for nontarget organisms were successfully prepared. The colloidal properties, swelling and release behaviors, leaf adhesion, degradation dynamics and bioactivity assay of the indoxacarb-loaded PU/SA nanoemulsions were determined. Results showed that the obtained indoxacarb-loaded microcapsule particulates were approximately 57 nm in diameter, electronegative −45.9 mV, and uniformly dispersed in the nanoemulsions. The dried latex films of PU/SA in the alkaline environment revealed better responsive swelling and release characteristics than those in acidic and neutral conditions. Compared with a commercial emulsifiable concentrate, the indoxacarb-loaded PU/SA nanoemulsions were useful for the targeted control of S. litura, which have alkaline gut and showed reduced acute contact toxicity to Harmonia axyridia. Furthermore, the PU/SA formulation had better foliage adhesion and indicated the property of controlled-release and a persistent effect.
48
Olechno, Katarzyna, Anna Basa, and Katarzyna Winnicka. "“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films." Materials 14, no. 17 (August 27, 2021): 4872. http://dx.doi.org/10.3390/ma14174872.
Full textAbstract:
Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.
49
Pichayakorn, Wiwat, Prapaporn Boonme, and Wirach Taweepreda. "Cosmetic Pore Packs from Deproteinized Natural Rubber Latex." Advanced Materials Research 844 (November 2013): 466–69. http://dx.doi.org/10.4028/www.scientific.net/amr.844.466.
Full textAbstract:
Natural rubber latex (NRL) from Hevea brasiliensis consists of cis-1,4-polyisoprene that have many excellent physical properties such as high elasticity, tensile strength, and easily film-forming. However, some proteins in NRL can cause allergy. Hence, this research aimed to prepare cosmetic pore packs from deproteinized NRL (DNRL) that was prepared in-house by enzyme treatment and centrifugation processes. The properties of DNRL were evaluated in terms of amount of remained protein, pH, particle size, polydispersity index, and zeta potential. This DNRL was then formulated the pore pack products by mixing with the other ingredients and casting to the film form. An appropriate pore pack formulation composed of sodium alginate and polyvinylpyrrolidone K30 mixed with DNRL to produce films with good properties. Hydroxypropylmethylcellulose was also added to another formulation for improving toughness of the films. Both products had similar appearance and physical properties such as thickness, uniformity of weight, pH, tensile strength, and elongation at break, but lower peel strength comparing with the commercial pore pack product. These films showed good flexibility, softness, and toughness. After storage at room temperature for a month, there were no different in appearance and pH that presented good stability. The obtained pore packs also exhibited desirable characteristics with acceptable volunteer satisfactions. However, they should be improved for more adhesiveness in further study. In conclusion, DNRL could be used as major component for cosmetic pore pack preparations.
50
Niu, Xiaoqing, Qianyun Ma, Shuiling Li, Wenxiu Wang, Yajuan Ma, Hongqian Zhao, Jianfeng Sun, and Jie Wang. "Preparation and Characterization of Biodegradable Composited Films Based on Potato Starch/Glycerol/Gelatin." Journal of Food Quality 2021 (January 28, 2021): 1–11. http://dx.doi.org/10.1155/2021/6633711.
Full textAbstract:
The use of plastics is resisted worldwide. Therefore, finding alternatives to plastic packaging products is an urgent issue. This work was dedicated to the preparation of biodegradable composited films with potato starch, glycerol, and gelatin. The formulation of the biodegradable film was first optimized via response surface methodology combined with the multi-index comprehensive evaluation method that considered physical properties (thickness, water solution (WS), tensile strength (TS) and elongation at break (E%)) and barrier property (light transmittance (T%)). Results indicated that the optimal conditions were 2.5% starch, 2.0% glycerol, and 1.5% gelatin (based on water). The optimized film presented excellent properties with TS of 4.47 MPa, E% of 109.91%, WS of 43.64%, and T% of 41.21% at 500 nm, and the comprehensive evaluation score of the composite film was 28.68. Moreover, a model verification experiment was further conducted, which proved that the predicted value highly matched experimental values, indicting the credibility and accuracy of the model. The resulting films were further characterized on the basis of rheological measurements, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The rheological measurements proved that the film-forming solution exhibited low shear viscosity and non-Newtonian fluid behavior. FTIR and SEM revealed excellent compatibility among starch, glycerol, and gelatin. Hence, the resulting optimized film may be expected to provide theoretical basis and technical support for the food packing industry.