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Dissertations / Theses on the topic 'First episode of psychosis'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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1

Upthegrove, Rachel. "Depression in first episode psychosis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1650/.

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There has been renewed interest into affective symptoms and psychological approaches to schizophrenia and other psychosis, yet no in-depth investigation as to the course, consequences or indeed psychological causes of depression in a phase specific manner in the important first episode. Our understanding of risk and aetiological processes in psychotic illness will only advance once we accurately identify the “end phenotype” of psychotic illness. This series of studies investigates the course of depression in first episode psychosis, its significance in terms of suicidal thinking, and relation

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2

Billings, J. "Making sense of first episode psychosis." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446413/.

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This paper addresses whether the concept of illness perceptions, which has been developed in the arena of chronic physical illness, can be applied to an acute mental illness such as first episode psychosis. Literature related to first episode psychosis and illness perceptions is reviewed and the potential benefits and problems of using the illness perceptions framework when trying to understand how people make sense of a first episode of psychosis are discussed. Finally, areas warranting exploration in further research are highlighted.

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3

Butjosa, Molines Anna. "Stressful life events and first-episode psychosis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/461706.

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Nowadays, advances in affective and social neuroscience have shown how the exposure to environmental factors has an impact on the structure and functioning of the brain being thus, active agents in the formation of an individual’s level of vulnerability. There is an increasing interest in the influence of stress on many diseases including a first-episode psychosis (FEP). From the stress-vulnerability model (Zubin & Spring, 1977) to the current models of neural diathesis-stress (Pruessner et al., 2017), schizophrenia is conceptualised as an episodic disorder in which there is vulnerability an

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4

Goodby, Emmeline. "Future-directed thinking in first episode psychosis." Thesis, Royal Holloway, University of London, 2014. http://digirep.rhul.ac.uk/items/ad1f1379-cc0a-ce62-ccf1-220f68ec8fc3/1/.

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Psychosis encompasses a constellation of symptoms that have far-reaching social, physical and functional consequences for sufferers. One of the key clinical concerns in the management of psychotic illnesses is the risk of suicide, which is greatest in the early stages of psychosis. Hopelessness is consistently associated with risk for suicide but as a concept it is not well defined and is not specific enough to be of use in prediction of suicide. Future-directed thinking, particularly regarding positive future events, constitutes an aspect of hopelessness that is closely associated with risk f

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5

Ajnakina, Olesya. "First episode psychosis : looking backwards and forwards." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/first-episode-psychosis(be65b62b-4c1a-496b-b7bf-3ada607e761d).html.

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Introduction: Psychotic disorders are known for their wide variability in clinical and social outcomes beginning from illness onset and throughout their course. Our current lack of understanding of the origins for this heterogeneity is further compounded by dearth in knowledge on how patients come to the attention of mental health services and methodological incongruity across different studies. Employing samples of first episode psychosis (FEP) patients, the aims of this thesis were to: 1) look back on the pathways to care patients used to enter mental health services and the use of prodromal

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6

Baggott, Eleanor. "Recovery from first-episode psychosis and the role for services beyond first-episode detection." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/36710/.

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Contemporary views of psychosis are more positive about outcomes and the potential for people with psychosis to have experiences of recovery. People who experience psychosis often use NHS services to help them manage their difficulties and specialist psychosis services, like Early Intervention (EI) are now common. However, it is not just secondary mental health services that are important in helping to manage people with psychosis. The first paper explores the role for primary care in managing this client group and systematically reviews the UK literature from 1997 on empirically tested method

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7

Meek, Ian Tod. "Satisfaction with antipsychotic medication in first episode psychosis." Thesis, University of East Anglia, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577566.

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Background: Antipsychotic medication is given in first episode psychosis in a prophylactic sense and also as a treatment. Young people experiencing their first episode of psychosis are generally the most responsive to pharmacological treatment. They are also the most susceptible to adverse events. Avoiding adverse events when individuals first start treatment is particularly important as the person's initial clinical experience may colour their attitude to medication thereafter. What it is like to take antipsychotic medication from the perspective of young people experiencing their first episo

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8

O'Donoghue, Emma. "Psychological flexibility in a first episode psychosis sample." Thesis, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542325.

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9

Raune, David John. "Psychosocial stress and the first episode of psychosis." Thesis, King's College London (University of London), 2002. https://kclpure.kcl.ac.uk/portal/en/theses/psychosocial-stress-and-the-first-episode-of-psychosis(7e57bcb0-2b09-488e-bd0a-5cf4e7f630d7).html.

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10

Kolliakou, Anna. "Patterns of cannabis use in first-episode psychosis." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/patterns-of-cannabis-use-in-firstepisode-psychosis(9d70beb1-9b58-4143-9bc6-87065b64866b).html.

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There is ample evidence that patients with psychosis are more likely to use illicit substances than the general population, with cannabis being the most popular. Research has also shown that cannabis use is associated with poor prognostic outcomes in patients with an established psychotic disorder. It is important to understand the reasons patients with psychosis endorse for their cannabis use and findings so far point towards an ‘alleviation of dysphoria’ model rather than the ‘self-medication’ hypothesis. It is not known how the level of motivation to change cannabis use can affect patients’

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11

Brunet, Katerine. "PTSD following recovery from a first episode of psychosis." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434704.

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12

Coulter, Carlton. "First-episode psychosis and the moral exculpation of parents." Thesis, University of East London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532930.

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In recent years a significant investment has been made in order to set up Early Intervention in Psychosis teams across England. These teams are responsible for delivering mental health services to people said to be experiencing first-episode psychosis, including the provision of 'psycho-education' for parents. The present study involved conducting eight interviews with such parents using a broad range of questions on the subject of first-episode psychosis. The study adopted a discursive psychology perspective towards the subject matter, with the analysis focusing on the rhetorical and interact

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13

Anderson, Richard J. "The epidemiology of first - episode psychosis in Northern Ireland." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534699.

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14

Kapasi, Masuma. "Cognitive function in first-episode psychosis : Infulences and outcomes." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520952.

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15

Tong, Chun-yat, and 湯俊逸. "Suicide ideation and first episode psychosis in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/192975.

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Patients with psychosis comprise a high-risk group in terms of suicide behaviors especially in the early phases. Suicide ideation on the other hand acts as the starting point along the chain of suicide. However less is known about suicide ideation among patients at their first-episode psychosis (FEP). Present study investigated contributing factors in suicidal ideation among FEP patients in Hong Kong. FEP outpatients (N=20) and normal controls (N=20) were invited to complete a set of self-assessment questionnaires. These questionnaires measured a wide range of potential risk factors includi

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16

Smith, Lindsay Murray. "Ethnic differences in caregiving processes in first-episode psychosis." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/ethnic-differences-in-caregiving-processes-in-firstepisode-psychosis(66f70fff-a099-4316-8d60-bda81da9bdb1).html.

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Background:Few studies have investigated the impact of caregiving on a national scale, or ethnic differences in caregiving processes. This is despite growing numbers of informal carers and demographic change in the UK. Individuals identifying as black African, black Caribbean, black British and black ‘other’ (BA_BAC) by UK Census ethnicity criteria (2001) are currently over-represented within psychiatric services in urban settings and are known to perceive statutory support to be inappropriate for their needs. Aim:Initially, to examine the mental and physical health consequences of caregiving

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17

Miller, Jason Michael. "Hope in primary caregivers' experience of first episode psychosis." Thesis, University of Leeds, 2010. http://etheses.whiterose.ac.uk/1086/.

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Introduction: Primary caregivers provide essential care and support to people with psychosis and are often key players within recovery. The recovery model and an expanding research literature suggest that the concept of hope is an important factor in adaptively coping with psychosis and also serves a critical role within recovery. The present study sought to explore how hope featured within the experiences of six primary caregivers of young people with first episode psychosis within the context of two UK early intervention services. Method: Interpretive Phenomenological Analysis was adopted as

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18

Achim, Amélie M. "Functional brain imaging of episodic memory in schizophrenia and first episode of psychosis." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111847.

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Memory is one of the cognitive functions that is most affected in schizophrenia and memory dysfunctions have a major impact on the functioning and quality of life of these patients. Functional brain imaging can help us identify the brain structures that are affected during the performance of a memory task. Identifying these regions can help us identify the specific cognitive processes that are affected in schizophrenia. To this end, I performed a meta-analysis of published functional brain imaging studies of episodic memory in schizophrenia. This meta-analysis showed that the prefrontal cortex

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19

Clarke, Rachel. "Possible selves in first episode psychosis : a mixed methods study." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/60861/.

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This study involved the application of possible selves theory to first episode psychosis (FEP) with the aims of understanding more about negative symptoms, functional outcomes and sense of self in FEP. A mixed-methods, explanatory sequential design was utilised. In the initial quantitative phase, a pre-existing data set of 80 participants allowed exploration of relationships between negative symptoms, functioning and possible selves. The qualitative phase, involving eight new participants, was then used to expand on specific findings from the quantitative phase, particularly how descriptions o

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20

Taylor, Hannah E. F. "Parents and young people in transition after first episode psychosis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3721/.

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A first episode of psychosis (FEP) is a significant life event for both a young person and their parent. This life event highlights a period of transition which is negotiated within the young person-parent relationship. The way in which the dyad reacts to and copes with the experience is important throughout the episode of FEP. Aims: This study aimed at describing how young people and their parents understand their experiences of FEP, and analysing how their relationships influenced recovery, and how psychosis and recovery affected the relationship itself. Method: A sample of ten participants,

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21

Hui, Lai-ming Christy, and 許麗明. "Predictors of relapse in first-episode schizophrenia and related psychosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41634081.

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22

Glossop, H. "Young people's beliefs about help-seeking for first episode psychosis." Thesis, Canterbury Christ Church University, 2012. http://create.canterbury.ac.uk/11213/.

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The importance of early intervention for positive outcomes following a first episode of psychosis (FEP) is recognised, however, there are still delays in young people seeking help. The aim of this qualitative study was to explore beliefs about help-seeking in young people who have recently experienced a FEP. Twelve participants were interviewed and transcripts were analysed using grounded theory. Five categories of beliefs were identified which contributed to the development of a preliminary model of beliefs about a need for help-seeking. Young people’s beliefs about their experiences as norma

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23

Morland, T. "The predictive factors of subjective recovery in first-episode psychosis." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444858/.

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Conceptualisations of recovery from psychosis have evolved over time, from medically defined models of symptom reduction, to more recent definitions of subjective recovery. First-episode psychosis (FEP) individuals present as a group who are in the early stages of adjustment to the experience of a psychotic illness. Due to the typically early age of onset, they are also in the process of adjusting to major life and role changes. This paper addresses how recovery from FEP has been conceptualised and measured in the literature, and focuses on the validity of applying such measures and concepts s

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24

Gee, Brioney. "Negative symptoms in first-episode psychosis : a mixed methods investigation." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/64222/.

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Negative symptoms – reductions in expression, motivation, pleasure and sociability – are observed across the spectrum of functional psychoses. They have been identified as a significant predictor of poor outcomes following first-episode psychosis and are a treatment priority for individuals with lived-experience of psychosis. However, the mechanisms underlying negative symptoms remain poorly understood. This thesis aims to contribute to our understanding of negative symptoms in the early phase of psychosis using a mixed methods approach. Participants in the EDEN study (n = 1006) were followed

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25

Hui, Lai-ming Christy. "Predictors of relapse in first-episode schizophrenia and related psychosis." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B41634081.

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26

Barkl, Sophie June. "Facial Emotion Identification in Early-Onset and First-Episode Psychosis." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15507.

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Psychotic conditions are a major public health concern as service expenditure costs are high, rates of unemployment are elevated, and risk of homelessness is increased. Improvements in the treatment of acute symptoms have resulted in many patients living in the community, which requires the ability to negotiate the social world. Social cognition refers to the set of skills involved in the perception, interpretation and effective use of social information. A fundamental building block of social cognition is the ability to quickly and accurately identify facial expressions of emotion (facial em

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27

Leirer, Daniel Jonathan. "Integrated approaches to the risk prediction of first-episode psychosis." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/integrated-approaches-to-the-risk-prediction-of-firstepisode-psychosis(62bde120-14b3-4584-ac9e-6ed86443d5b7).html.

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Psychosis is a complex condition that features in many psychiatric disorders, and significantly affects the quality of life for both patients and family members. As part of the Genetics and Psychosis (GAP) study, this thesis presents one of the largest blood gene expression datasets on first-episode psychosis patients to date. This work aimed to characterise the blood-based biological perturbations in psychosis and to investigate the predictive ability of gene expression data. Firstly changes in expression, between healthy controls and first-episode psychosis patients was explored, to identify

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28

Harris, Samantha. "Exploring young people's constructions of a first episode of psychosis." Thesis, University of East London, 2016. http://roar.uel.ac.uk/5410/.

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Background: Mental health services have been demonstrated to play a key role in shaping how people make sense of their experiences of psychosis. Past research has highlighted the dominance of the biomedical model within services, however, first-person accounts suggest this is not always meaningful or helpful for recovery. Early Intervention in Psychosis (EIP) services aim to provide a more holistic, non-stigmatising approach for young people experiencing a First Episode of Psychosis (FEP). However, there is very limited research exploring how these services might impact upon how young people c

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29

Barajas, Vélez Ana. "Premorbid and prodromal functioning as predictors at onset of psychosis: a first-episode study." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/377764.

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Las fases tempranas de una enfermedad representan un período importante, tanto desde el punto de vista de la investigación como en relación al resultado de la enfermedad y su pronóstico. En relación con los trastornos el espectro psicótico, se ha observado que la heterogeneidad comienza temprano, mucho antes de la aparición de la psicosis. En este sentido, es posible que factores que influyen en las fases premórbida y prodrómica puedan ser entendidos como factores de riesgo moduladores de la expresión de los síntomas psicóticos. Entonces, ampliar nuestro conocimiento sobre la caracterización d

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Christoforidis, Gina. "First episode psychosis: an IPA exploration of the experiences of partners." Thesis, University of Surrey, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576117.

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There exists a wealth of research which suggests that for family members, caring for an individual with psychosis can be a distressing experience. However, despite the growing body of literature surrounding First Episode Psychosis (FEP) and caregivers, the experiences of partners have somehow been neglected. This study aimed to bridge this gap in the literature by exploring partners' experiences of being with an individual who has recently developed psychosis, investigating the impact on the individual and the relationship from a transitions perspective. Six partners of individuals within one

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31

Tso, F., and 曹斐. "Longitudinal neurocognitive functions in First-episode psychosis: 24-month follow-up." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31227909.

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32

Revell, Emily. "Combined cognitive remediation and social cognition training in first episode psychosis." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/combined-cognitive-remediation-and-social-cognition-training-in-first-episode-psychosis(a309c184-9478-4763-b2a2-2547463e08da).html.

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Introduction: Impaired neurocognition, especially social cognition, predicts disability in schizophrenia. Early intervention to target impairment is theoretically attractive as a means to minimise chronic disability. Many trials confirm that Cognitive Remediation (CR) produces meaningful, durable improvements in cognition and functioning but few interventions remediate social cognition or focus on the early stages of schizophrenia. Methods: A systematic review and meta-analysis of 11 randomised controlled trials (RCTs) of CR in first episode psychosis (FEP) was completed. A randomised controll

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33

S, Mok L. "Social anxiety and low grade symptoms in patients following first episode psychosis." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3138576X.

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34

Mattsson, Maria. "First episode psychosis and outcome : findings from a Swedish multi-centre study /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-338-2/.

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Mok, L. S., and 莫麗莎. "Social anxiety and low grade symptoms in patients following first episode psychosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3138576X.

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36

Penny, Elizabeth. "How is first episode psychosis and early intervention understood by Pakistani families?" Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/31218.

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Section A: Literature Review : How are Mental Health Problems and Mental Health Services Understood in British Asian Communities? The review outlines literature relating to Asian communities in Britain and their beliefs about and experience of mental illness, particularly psychosis. It particularly examines the experience of Asian service users and carers. The review highlights cultural differences in the understanding and treatment of mental illness. It also suggests specific difficulties these communities have in accessing services. Section B: Research Report: How Is First Episode Psychosis

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37

Press, Claire. "Developing culturally adapted cognitive remediation for South Asian first episode psychosis sufferers." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/developing-culturally-adapted-cognitive-remediation-for-south-asian-first-episode-psychosis-sufferers(9dd2210e-3587-4acc-986b-5f2121467ff5).html.

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Introduction: An increased incidence of schizophrenia among migrant and ethnic minority groups has been established. Ethnic minorities have poorer access to and outcomes from evidence based psychosocial interventions compared to the majority population. The overall aims of this thesis was to explore culturally adapted psychosocial interventions for migrant and ethnic minority schizophrenia sufferers, and use the results of these investigations to develop culturally adapted cognitive remediation (CR) to meet the needs of South Asian first episode sufferers. Methods: A systematic review and meta

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Berry, Christopher. "Subjective experiences of psychosis : investigating the psychological impact of first-episode psychosis using Interpretative Phenomenological Analysis (IPA)." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419375.

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39

Wong, Wun-tsang, and 黃韻錚. "A qualitative study on the admission experience of patients with first-episode psychosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206557.

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Background: For early psychosis patients, the first few years were critical period for determining long-term illness outcome. The first experience of admission had significant bearing on the perception of subsequent psychiatric treatment received. From this perspective, it was important to be aware of how patients suffered and how they coped in order to regain their sense of self of insight and treatment adherence and trust with nurses’ rapport and their therapeutic relationship. In this regard, a qualitative study was done with an aim to (i) explore the admission experiences and beliefs parti

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Windell, Deborah L. "Treatment and recovery in first-episode psychosis : a qualitative analysis of client experiences." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100177.

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Background: There is currently very little research on recovery from the perspective ofindividuals with recent-onset of psychotic disorders. Forming a better understanding ofthesubjective meaning ofrecovery and recovery experiences during this early phase ofrecovery caninform effective and meaningful service design and practices.Method: Thirty individuals recovering from psychosis and receiving specialized earlyinterventiontreatment were interviewed regarding the meaning and experience of recovery frompsychosis during the early phase (2-5 years) ofthe illness course.Results: Recovery was descr

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Hovington, Cindy. "Understanding persistent negative symptoms in first episode psychosis: Implementing neurocognitive and neuroanatomical approaches." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121181.

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Background. Negative symptoms (alogia, blunted affect, amotivation, reduced social drive) are a core feature of psychotic disorders. In comparison to positive symptoms, negative symptoms do not respond well to treatment, thus becoming persistent in a large percentage of psychosis patients. Persistent negative symptoms (PNS) remain an unmet therapeutic need, in part, due to our lack of understanding of the cognitive and neural correlates of these symptoms. Furthermore, most studies ill investigate PNS in patients with enduring schizophrenia, which introduces confounding factors. Hence, there i

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Thorrington, Selina. "Implicit and explicit self-stigma, psychological flexibility and outcomes in first episode psychosis." Thesis, Canterbury Christ Church University, 2013. http://create.canterbury.ac.uk/12336/.

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Section A reviews the literature from two areas: it looks first at empirical studies exploring self-stigma in psychosis and secondly at psychological flexibility in psychosis. In doing so, the review aims to consider the question as to whether the psychological flexibility model, as presented by Acceptance and Commitment Therapy, can help us to understand how and why self-stigma can have a detrimental impact on some individuals experiencing symptoms of psychosis. Section B reports on a quantitative study of self-stigma, psychological flexibility, psychological well-being and quality of life in

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Hodgekins, Joanne. "Investigating the psychological typology of social recovery in individuals with first episode psychosis." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42396/.

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Background Social disability has long been linked with psychosis. However, at what stage disability occurs, whether it exists for all individuals, and factors predicting outcome are still under debate. Assessing social functioning in first episode psychosis (FEP) presents a methodological challenge as many existing tools were developed for chronic schizophrenia and are confounded with psychotic symptoms. Aims This study explored the prevalence and typology of social disability in FEP. Different trajectories of social recovery were examined as well as predictors of outcome. Method A sample of 8

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Edge, Rachael Sarah. "Journeys into recovery : family narratives of first episode psychosis and behavioural family therapy." Thesis, Staffordshire University, 2015. http://eprints.staffs.ac.uk/2239/.

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This thesis explores the journeys undertaken by families when someone experiences a first episode of psychosis (FEP), and the family seeks help and receives treatment. A review of the literature on families' experiences of help-seeking for FEP provides a focus on the beginning of this time. The literature is synthesised to reveal a journey through the early help-seeking experience, and the extent to which experiences are shared between carers and individuals with FEP is explored. The empirical research paper provides insight into families' experiences further along on their journey; presenting

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Maidment, Megan. "Social recovery following first-episode psychosis : the role of negative symptoms and motivation." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/50723/.

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Background Impairment in social functioning following psychosis is associated with negative symptoms, particularly reduced motivation (Foussias & Remington, 2010). Cognitive models of negative symptoms propose that expectancy appraisals are involved in the expression and maintenance of negative symptoms (Rector, Beck, & Stolar, 2005; Staring & Van der Gaag, 2010). Theories of motivation (e.g. expectancy-value theory; Eccles and Wigfield 2002) describe how self-efficacy beliefs, appraisals of task value, and self-schema may influence behaviour, but minimal research has applied these models to t

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Merritt, Kate Sky. "Glutamate dysfunction in first episode psychosis and relationship with the response to treatment." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/glutamate-dysfunction-in-first-episode-psychosis-and-relationship-with-the-response-to-treatment(082da8ec-6d0b-49d6-87fa-e03939e92ac8).html.

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Abnormal glutamatergic neurotransmission is strongly implicated in the pathophysiology of schizophrenia. The main technique available for assessing central glutamate function in man in vivo is proton magnetic resonance spectroscopy (1H-MRS), which can be used to measure glutamate, its metabolite glutamine, or their combination (Glx). Although around sixty 1H-MRS studies in schizophrenia have been published, the findings have been inconsistent, and the extent to which these vary with the brain region examined, the stage of the disorder, the severity of symptoms and the effects of treatment is u

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Jackson, D. "Understanding treatment delay in first episode psychosis : the parents' experience of help seeking." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445666/.

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This thesis is presented in three parts. Part One is a literature review, in which the empirical literature that investigated the relationship between a range of psychosocial variables and 'duration of untreated psychosis' (DUP) is reviewed. Part Two presents the empirical paper, describing the main qualitative study for this thesis. The study explored the experiences, perceptions and beliefs of the parents of 14 young people who had recently experienced a first episode of psychosis and who delayed seeking help from mental health services. Part Three represents a critical appraisal of the stud

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48

Bioque, Alcázar Miquel. "Neuroinflammation in first episodes of psychosis." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/125776.

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Around 3% of the general population suffers a first episode of psychosis (FEP). The population of FEPs represents a unique opportunity to study psychotic disorders in general and schizophrenia in particular, avoiding confounding variables such as antipsychotic treatment, comorbidity and chronicity. Several hypotheses that involve the immune system and neuroinflammatory processes have been proposed as etiological explanations of psychosis. Most of the available scientific evidence has been found in populations with established schizophrenia. Few studies indicate alterations, often subtle, in

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Scoriels, Linda. "Metabolic, cognitive and emotional endophenotypes in first episode psychosis : characterisation and a potential treatment." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609222.

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Breitborde, Nicholas JK, Emily K. Bell, David Dawley, et al. "The Early Psychosis Intervention Center (EPICENTER): development and six-month outcomes of an American first-episode psychosis clinical service." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610297.

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BACKGROUND: There is growing evidence that specialized clinical services targeted toward individuals early in the course of a psychotic illness may be effective in reducing both the clinical and economic burden associated with these illnesses. Unfortunately, the United States has lagged behind other countries in the delivery of specialized, multi-component care to individuals early in the course of a psychotic illness. A key factor contributing to this lag is the limited available data demonstrating the clinical benefits and cost-effectiveness of early intervention for psychosis among individu

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