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1

Harvey, Samuel B., Kimberlie Dean, Craig Morgan, et al. "Self-harm in first-episode psychosis." British Journal of Psychiatry 192, no. 3 (2008): 178–84. http://dx.doi.org/10.1192/bjp.bp.107.037192.

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BackgroundLittle is known about self-harm occurring during the period of untreated first-episode psychosis.AimsTo establish the prevalence, nature, motivation and risk factors for self-harm occurring during the untreated phase of first-episode psychosis.MethodAs part of the æSOP (Aetiology and Ethnicity in Schizophrenia and Other Psychoses) study, episodes of self-harm were identified among all incident cases of psychosis presenting to services in south-east London and Nottingham over a 2-year period.ResultsOf the 496 participants, 56 (11.3%) had engaged in self-harm between the onset of psych
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2

Zanetti, Marcus V., Maristela S. Schaufelberger, Cláudio C. de Castro, et al. "White-matter hyperintensities in first-episode psychosis." British Journal of Psychiatry 193, no. 1 (2008): 25–30. http://dx.doi.org/10.1192/bjp.bp.107.038901.

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BackgroundWhite-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studiesAimsTo examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorderMethodT2-weighted magnetic resonance imaging data were acquired in 129 individuals with first-episode psychosis (either affective or non-affective psychoses) and 102 controls who were randomly selected from the same geographical areas. Visual white-matter hyperintensity rati
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Amini, Homayoun, Javad Alaghband-Rad, Abbas Omid, et al. "Diagnostic Stability in Patients with First-Episode Psychosis." Australasian Psychiatry 13, no. 4 (2005): 388–92. http://dx.doi.org/10.1080/j.1440-1665.2005.02199.x.

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Objective: To examine the short-term stability of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) and International Classification of Diseases (10th revision; ICD-10) diagnoses in a group of patients with first-episode psychosis. Method: Sixty patients with first-episode psychosis admitted consecutively to Roozbeh Hospital, Tehran, were sampled; their illnesses could not be attributed to any medical or substance-induced conditions. Patients were assessed at the time of discharge from the hospital, and at 3, 6and 12 month intervals following admission. Ateach visit, two
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4

Rogers, Paul. "First episode psychosis." Mental Health Practice 9, no. 3 (2005): 37. http://dx.doi.org/10.7748/mhp.9.3.37.s31.

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5

Sandor, A. "First episode psychosis." BMJ 324, no. 7343 (2002): 976a—976. http://dx.doi.org/10.1136/bmj.324.7343.976/a.

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6

Milton, John, Shazad Amin, Swaran P. Singh, et al. "Aggressive incidents in first-episode psychosis." British Journal of Psychiatry 178, no. 5 (2001): 433–40. http://dx.doi.org/10.1192/bjp.178.5.433.

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BackgroundRecent research has reported increased risk of aggressive incidents by individuals with psychotic illness.AimsTo examine acts of aggression in first-episode psychosis.MethodSubjects with a first-episode psychosis were ascertained from a defined catchment area (Nottingham, UK) and reassessed at 3 years (n=166) using clinical interview, informants, health care and forensic records.ResultsOf the subjects, 9.6% demonstrated at least one act of serious aggression (defined as weapon use, sexual assault or victim injury) during at least one psychotic episode and 23.5% demonstrated lesser ac
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7

Singh, Swaran P., Tom Burns, Shazad Amin, Peter B. Jones, and Glynn Harrison. "Acute and transient psychotic disorders: precursors, epidemiology, course and outcome." British Journal of Psychiatry 185, no. 6 (2004): 452–59. http://dx.doi.org/10.1192/bjp.185.6.452.

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BackgroundICD–10 has introduced the diagnostic group acute and transient psychotic disorders (ATPDs; F23). Aims To validate the nosological distinctiveness of ICD–10 ATPDs by following up an inception cohort with first-episode psychosis. Method All patients with first-episode psychosis identified in Nottingham between 1992 and 1994 and diagnosed using ICD–10 criteria were reassessed 3 years later. ATPD outcomes were compared with schizophrenia and affective psychosis. Multivariate analyses were conducted to determine whether acute onset and early remission predicted favourable 3-year outcome i
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8

Patel, Kamlesh, and Rachel Upthegrove. "Self-harm in first-episode psychosis." Psychiatric Bulletin 33, no. 3 (2009): 104–7. http://dx.doi.org/10.1192/pb.bp.108.020362.

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Aims and MethodSuicide in schizophrenia remains frequent. One of the best predictors of suicide, previous self-harm, is increasing in young people. the aim of this case-note review was to investigate the frequency of a history of self-harm for individuals presenting to psychiatric services with a first episode of psychosis in our local area and study their demographic characteristics.ResultsA history of self-harm was found in 32% of the cohort. the predominant method of self-harm was self-laceration. In univariate analyses, age and gender were significant predictors of self-harming behaviour.C
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9

Edwards, Jane, Dana Maude, Patrick D. McGorry, Susan M. Harrigan, and John T. Cocks. "Prolonged recovery in first-episode psychosis." British Journal of Psychiatry 172, S33 (1998): 107–16. http://dx.doi.org/10.1192/s0007125000297754.

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Background Early identification and specialised treatment of individuals with enduring positive symptoms may assist in alleviating symptoms and has the potential to change the course of illness.Method Prevalence and descriptive data on enduring positive symptoms in two first-episode samples are outlined. Attempts to incorporate the focus of early intervention for persisting psychosis into routine clinical care of individuals with first-episode psychosis are described.Results Of the 227 individuals with first-episode psychosis who were assessed using the Brief Psychiatric Rating Scale at 3/6 mo
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10

Karki, B. D., D. Joshi, and A. P. Adhikari. "Stressful Life Events In First Episode Psychosis." Journal of Psychiatrists' Association of Nepal 10, no. 1 (2021): 38–42. http://dx.doi.org/10.3126/jpan.v10i1.40346.

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Introduction: First episode psychosis refers to the first time someone experiences psychotic symptoms or a psychotic episode. There are evidences related to the role of major life events and childhood trauma in the development of first episode psychosis. There are few studies regarding the environmental exposure to stressful life events and how these events might influence the onset of a psychotic disorder, and role of perceived stress. This study aimed to identify the relationship between stressful life events and first episode psychosis in Nepalese context.
 Material And Method: It was
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11

Kopala, Lili C. "Maximizing Function After First-Episode Psychosis." CNS Spectrums 9, S11 (2004): 34–39. http://dx.doi.org/10.1017/s1092852900025116.

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AbstractInterest in early and preventive interventions in patients with psychotic disorders has increased over the past few years as a result of die intuitive appeal of such interventions. Results of studies point to an association between longer duration of untreated psychosis and poor outcome, atypical antipsychotic agents less likely to cause extrapyramidal side effects, and a shift from hospital to community-based care for many patients with severe mental illness. Treatment strategies specifically directed to firsUepisode psychosis may help to improve outcomes. Such strategies include the
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12

Marques, S., F. Godinho, A. L. Melo, and D. Barrocas. "First-episode psychosis: What does it mean?" European Psychiatry 33, S1 (2016): s258. http://dx.doi.org/10.1016/j.eurpsy.2016.01.656.

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IntroductionFirst-Episode Psychosis (FEP) is a variable condition, characterized by the emergence of new psychotic features for a period of at least 1 week. The majority of existing studies about FEP only address schizophrenia spectrum psychosis (SSP), which may limit the capacity to fully characterize this entity.Objectives/AimsReport the clinical and socio-demographic characteristics of patients with FEP in real-world setting, and compare the differences among SSP and affective FEP.MethodsRetrospective analysis of clinical files of patients admitted to our hospital unit with FEP diagnosis fr
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13

Cantwell, Roch, John Brewin, Cristine Glazebrook, et al. "Prevalence of substance misuse in first-episode psychosis." British Journal of Psychiatry 174, no. 2 (1999): 150–53. http://dx.doi.org/10.1192/bjp.174.2.150.

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BackgroundReports suggest a high prevalence of substance misuse in psychotic disorders but few studies examine comorbidity at onset of psychosis.AimsTo identify the prevalence and pattern of substance use and misuse in first-episode psychosis, and relationships with diagnosis, mode of presentation and demographic variables.MethodConsensus diagnoses for 168 subjects presenting with first-episode psychosis were made using ICD–10 diagnostic criteria. Information on substance use and misuse was obtained from multiple sources. We examined associations between substance misuse, diagnosis and demogra
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14

Dazzan, Paola, Tuhina Lloyd, Kevin D. Morgan, et al. "Neurological abnormalities and cognitive ability in first-episode psychosis." British Journal of Psychiatry 193, no. 3 (2008): 197–202. http://dx.doi.org/10.1192/bjp.bp.107.045450.

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BackgroundIt remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis.AimsTo investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ).MethodEvaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general
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Pariante, Carmine M., Konstantina Vassilopoulou, Dennis Velakoulis, et al. "Pituitary volume in psychosis." British Journal of Psychiatry 185, no. 1 (2004): 5–10. http://dx.doi.org/10.1192/bjp.185.1.5.

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BackgroundPatients with psychosis have activation of the hypothalamic-pituitary-adrenal (HPA) axis during the acute phase of the psychosis. Whether this has any morphological consequences for the pituitary gland is currently unknown.AimsTo examine pituitary volume variation in people at different stages of psychotic disorder.MethodPituitary volume was measured using 1.5 mm, coronal magnetic resonance images in 24 people with first-episode psychosis, 51 with established schizophrenia and 59 healthy controls.ResultsCompared with the control group, the people with first-episode psychosis had pitu
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16

Amin, Shazad, Swaran P. Singh, John Brewin, Peter B. Jones, Ian Medley, and Glyn Harrison. "Diagnostic stability of first-episode psychosis." British Journal of Psychiatry 175, no. 6 (1999): 537–43. http://dx.doi.org/10.1192/bjp.175.6.537.

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BackgroundThe temporal stability of a diagnosis is one measure of its predictive validity.AimsTo measure diagnostic stability in first-episode psychosis using ICD–10 and DSM–III–R.MethodBetween 1992 and 1994 we ascertained a cohort of persons with first-episode psychosis (n=168), assigning to each a consensus diagnosis. At three-year follow-up, longitudinal consensus diagnoses, blind to onset diagnoses, were made. Stability was measured by the positive predictive values (PPVs) of onset diagnoses. For onset schizophrenia, we also calculated sensitivity, specificity and concordance (κ).ResultsFi
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17

Breitborde, Nicholas J. K., Cindy Woolverton, R. Brock Frost, and Nicole A. Kiewel. "Self-Determination Theory and First-Episode Psychosis: A Replication." Advances in Psychiatry 2014 (September 8, 2014): 1–5. http://dx.doi.org/10.1155/2014/240125.

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Self-determination theory (SDT) posits that human well-being depends on the satisfaction of three basic psychological needs: autonomy, competence, and relatedness. Although many scholars have suggested that SDT may be relevant to psychotic disorders, only one empirical study of SDT in individuals with psychosis has been completed to date by Breitborde and colleagues (2012). This study revealed that individuals with first-episode psychosis reported lower satisfaction of the three basic psychological needs as compared to individuals without psychosis. Moreover, greater satisfaction of basic psyc
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18

Coentre, R., D. Barrocas, I. Chendo, and P. Levy. "First Psychotic Episode and Early Intervention: An Opportunity to Change the Course of the Illness." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71358-6.

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Aims:Early intervention in psychosis constitutes an important opportunity to change the classic limited outcome associated with the patients who suffer of psychotic disease.Methods:Based on literature review the authors analyse the evidence for early intervention in first psychotic episode.Results:The evidence for the effectiveness of interventions in early psychosis can be considered in two stages:1.first stage before the onset of full symptoms of psychosis, in people with high risk of developing psychosis or in the prodrome phase of the illness;2.second stage includes the therapeutic focus o
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19

Tan, Hao-Yang, Yong-Guan Ang, Hao-Yang Tan, and Yong-Guan Ang. "First-Episode Psychosis in the Military: A Comparative Study of Prodromal Symptoms." Australian & New Zealand Journal of Psychiatry 35, no. 4 (2001): 512–19. http://dx.doi.org/10.1046/j.1440-1614.2001.00912.x.

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Objective: The objective of this study is to provide a retrospective description of prodromal symptoms of young military servicemen with first-episode psychosis, and a comparison with first-episode non-psychotic disorders. Method: Thirty consecutive servicemen presenting with first-episode psychosis were studied. Thirty-four randomly selected servicemen from 123 with non-psychotic disorders served as comparison. A combination of unstructured and semistructured interviews with the patient and other informants was used to describe the prodromal symptoms. Results: The most common prodromal psycho
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Gil-Berrozpe, G., V. Peralta, A. Sánchez-Torres, et al. "Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis." European Psychiatry 65, S1 (2022): S247. http://dx.doi.org/10.1192/j.eurpsy.2022.637.

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Introduction First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptomatology remain to be ascertained. Objectives First, we ascertained whether the structure of psychopathological symptoms, dimensions and domains of psychopathology remains invariant over time between first-episode psychosis and long-term follow-up. Second, we analysed the changes in the interrelations
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Mota-Oliveira, M., M. J. Peixoto, I. Ferraz, et al. "Diagnostic Stability in First Psychotic Episode after 5 years follow-up." European Psychiatry 41, S1 (2017): S197. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2138.

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IntroductionThe diagnosis of psychosis is based on the presence or absence of characteristic symptoms. The presence of such symptoms varies during the course and treatment, raising the question of diagnostic stability after a first psychotic episode.Aims and objectivesThe aim of this study is to evaluate the diagnostic stability after a first psychotic episode in the long term (five years after the first inpatient admission).MethodologyA retrospective study that included patients with first psychotic episode between 2007 and 2011 admitted to the inpatient unit of the psychiatry and mental heal
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Elsawy, H. F., M. A. Abd Elhay, and A. B. Abd Elkrem. "FC07-01 - Cognitive functions in first episode psychosis." European Psychiatry 26, S2 (2011): 1846. http://dx.doi.org/10.1016/s0924-9338(11)73550-7.

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BackgroundCognitive impairment is recognized as an important feature of psychosis in its early stages and is a determinant of prognosis and management of these disorders.Aim of the studyTo test the cognitive functions in first psychotic episode in patients with disorders of schizophrenia, schizoaffective disorder, bipolar disorder and depression with psychotic disorder and to compare them to controls.Subjects and methodsThe study included 254 patients diagnosed according to Diagnostic and Statistical criteria of Mental disorders, 4th edition (91 schizophrenics, 21 with schizoaffective disorder
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Menezes, Paulo R., Marcia Scazufca, Geraldo F. Busatto, Letícia M. S. Coutinho, Philip K. Mcguire, and Robin M. Murray. "Incidence of first-contact psychosis in São Paulo, Brazil." British Journal of Psychiatry 191, S51 (2007): s102—s106. http://dx.doi.org/10.1192/bjp.191.51.s102.

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BackgroundLittle is known about the incidence of first-episode psychosis in urban centres of low- or middle-income countriesAimsTo estimate the incidence of psychosis in São Paulo, a large metropolis of BrazilMethodProspective survey of first-episode psychosis among residents aged 18–64 years resident in a defined area of São Paulo, over a 30-month period (July 2002- December 2004). Assessments were carried out with the SCID–I, and diagnoses given according to DSM – IV criteria. Population at risk was drawn from the 2000 Census dataResultsThere were 367 first-episode cases identified (51% wome
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Lloyd, T., P. Dazzan, K. Dean, et al. "Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity." Psychological Medicine 38, no. 1 (2007): 71–77. http://dx.doi.org/10.1017/s0033291707001158.

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BackgroundAn increased prevalence of minor physical anomalies (MPAs) has been extensively documented in schizophrenia but their specificity for the disorder remains unclear. We investigated the prevalence and the predictive power of MPAs in a large sample of first-episode psychotic patients across a range of diagnoses.MethodMPAs were examined in 242 subjects with first-episode psychosis (50% schizophrenia, 45% affective psychosis and 5% substance-induced psychosis) and 158 healthy controls. Categorical principal components analysis and analysis of variance were undertaken, and individual items
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Coentre, Ricardo, Amilcar Silva-dos-Santos, and Miguel Cotrim Talina. "Retrospective study on structural neuroimaging in first-episode psychosis." PeerJ 4 (May 26, 2016): e2069. http://dx.doi.org/10.7717/peerj.2069.

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Background.No consensus between guidelines exists regarding neuroimaging in first-episode psychosis. The purpose of this study is to assess anomalies found in structural neuroimaging exams (brain computed tomography (CT) and magnetic resonance imaging (MRI)) in the initial medical work-up of patients presenting first-episode psychosis.Methods.The study subjects were 32 patients aged 18–48 years (mean age: 29.6 years), consecutively admitted with first-episode psychosis diagnosis. Socio-demographic and clinical data and neuroimaging exams (CT and MRI) were retrospectively studied. Diagnostic as
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Marques, Tiago Reis, Shubulade Smith, Stefania Bonaccorso, et al. "Sexual dysfunction in people with prodromal or first-episode psychosis." British Journal of Psychiatry 201, no. 2 (2012): 131–36. http://dx.doi.org/10.1192/bjp.bp.111.101220.

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BackgroundSexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors.AimsTo compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.MethodSexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.ResultsThere was a significant ef
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Molina, V., J. Sanz, S. Reig, et al. "Hypofrontality in men with first-episode psychosis." British Journal of Psychiatry 186, no. 3 (2005): 203–8. http://dx.doi.org/10.1192/bjp.186.3.203.

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BackgroundDecreased metabolic activity in the prefrontal cortex during cognitive activation is a recurrent finding and a likely functional marker of schizophrenia.AimsTo investigate the occurrence of hypofrontality in patients with first-episode psychosis, with or without evolution to schizophrenia.MethodWe used fluorodeoxyglucose positron emission tomography during the performance of an attention task and magnetic resonance imaging to study the dorsolateral prefrontal region in 13 men with a first episode of psychosis. Data from patients who progressed to schizophrenia were compared with thos
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Buckley, Peter F., Christoph U. Correll, and Alexander L. Miller. "First-Episode Psychosis: A Window of Opportunity for Best Practices." CNS Spectrums 12, S15 (2007): 1–16. http://dx.doi.org/10.1017/s1092852900026213.

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AbstractPatients experiencing a first psychotic episode or early stages of psychosis present with key diagnostic issues for clinicians. At the time of first-episode psychosis presentation, it is crucial that clinicians select the most effective treatment option as immediate intervention offers the best chance for containing the illness. Functional impairment occurs most rapidly at the early stage of illness, and such impairment can influence the patient's future prognosis, alter the level of necessary treatment, and affect morbidity. Although research has shown a decrease in brain gray matter
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Melo, B., C. Alves Pereira, R. Cajão, J. Ribeiro Silva, S. Pereira, and E. Monteiro. "First-episode psychosis intervention – description of our early intervention model." European Psychiatry 41, S1 (2017): s823. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1607.

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IntroductionThe research about the benefits of early diagnosis and treatment of first-episode psychosis had significantly increased in last decades. There have been several early intervention programs in psychotic disease, implemented worldwide, in order to improve the prognosis of these psychotic patients.ObjectivesTo present a brief description of the first-episode psychosis intervention team of Tondela-Viseu Hospital Centre–Portugal and its model. We aim to further characterize our population and describe its evolution since 2008.AimsWe aim to clarify the benefits of an early intervention i
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Gleeson, John. "Preventing Episode II: Relapse Prevention in First-Episode Psychosis." Australasian Psychiatry 13, no. 4 (2005): 384–87. http://dx.doi.org/10.1080/j.1440-1665.2005.02198.x.

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Objective: This paper outlines a rationale for expanding research and clinical innovations focused upon relapse prevention following a first episode of psychosis. Some general principles for further progress are extracted from an overview of the first-episode psychosis (FEP) relapse literature. A cognitive behaviour therapy intervention for relapse prevention for FEP, that has been developed at the Early Psychosis Prevention and Intervention Centre, is described to illustrate these principles. Conclusions: Further progress is needed in refining interventions specific to the prevention of relap
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Martínez, L., A. Mané, R. Cortizo, et al. "Insight and Social Cognition in First Episode of Psychosis." European Psychiatry 41, S1 (2017): S272. http://dx.doi.org/10.1016/j.eurpsy.2017.02.102.

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IntroductionImpairment of insight in psychotic disorder is associated with adverse impact in treatment compliance, outcome and social functioning although its underlying mechanisms are still unknown. Social cognition and more specifically Theory of mind have been proposed to be correlated to insight. However, the relationship between both factors is still not well defined.AimsTo study the association between social cognition and insight into mental illness in individuals with early psychosis included in the first episode of psychosis program of Hospital del Mar.MethodsFrom the 94 patients incl
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Melle, I., S. Friis, U. Haahr, et al. "Measuring quality of life in first-episode psychosis." European Psychiatry 20, no. 7 (2005): 474–83. http://dx.doi.org/10.1016/j.eurpsy.2005.03.002.

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AbstractQuality of life (QoL) measures are increasingly recognized as necessary parts of outcome assessments in psychosis. The present paper is a comprehensive study of patients with first-episode psychosis where QoL is measured by the commonly used Lehman Quality of Life Interview (L-QoLI). The aim is to examine if the L-QoLI maintain its original structure when used in a group of patients with first-episode psychosis, and to investigate what determines global subjective QoL with a specific emphasis on premorbid adjustment, duration of untreated psychosis (DUP) and clinical symptoms. The stud
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NORMAN, R. M. G., A. K. MALLA, M. B. VERDI, L. D. HASSALL, and C. FAZEKAS. "Understanding delay in treatment for first-episode psychosis." Psychological Medicine 34, no. 2 (2004): 255–66. http://dx.doi.org/10.1017/s0033291703001119.

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Background. A lengthy delay often occurs between the onset of symptoms of psychotic disorders and initiation of adequate treatment. In this paper we examine the extent to which this represents a delay in individuals contacting health professionals or a delay in receiving treatment once such contact is made.Method. Pathways to care were examined in 110 patients of the Prevention and Early Intervention Program for Psychosis in London, Canada. Data were collected using structured interviews with patients, family members, consultation with clinicians and review of case records.Results. Family phys
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Schimmelmann, B., S. Kupferschmid, P. Conus, S. Cotton, P. McGorry, and M. Lambert. "Cannabis use disorders and age at onset of psychosis in 606 patients with first episode psychosis." European Psychiatry 26, S2 (2011): 1500. http://dx.doi.org/10.1016/s0924-9338(11)73204-7.

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BackgroundAge at onset of psychosis (AAO) may be younger in patients with cannabis use disorders (CUD) compared to those without CUD (NCUD). Most previous studies did not control for potential confounders, did not report effect sizes and included mostly adult patients from non-representative samples.MethodsControlling for relevant confounders, differences in AAO between patients with and without lifetime CUD were analysed in a large epidemiologically based cohort of 606 first-episode psychosis (FEP) patients (age 14 to 29 years) admitted within three years to the Melbourne Early Psychosis Prev
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GOUVEA, EDUARDO SAUERBRONN, CRISTIANO NOTO, BIANCA BONADIA, et al. "FIRST-EPISODE PSYCHOSIS: EMERGENCY ASSISTANCE." Revista Debates em Psiquiatria Ano 4 (December 1, 2014): 16–23. http://dx.doi.org/10.25118/2236-918x-4-6-2.

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O termo psicose é usado para descrever um estado mental em que o indivíduo perde o contato com a realidade, e a etapa inicial de manifestação dos sintomas psicóticos define o primeiro episódio psicótico (PEP). Este artigo apresenta conceitos e dados gerais sobre PEP, apresenta fatores de risco e provê orientações sobre o diagnóstico (inclusive diagnósticos diferenciais), tratamento e acompanhamento de pacientes com PEP, com destaque para o papel das emergências psiquiátricas. As diferentes fases das psicoses também são descritas. Como conclusão, os autores salientam a importância da identifica
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Chiliza, Bonga, Piet Oosthuizen, and Robin Emsley. "First-episode psychosis: An update." South African Journal of Psychiatry 14, no. 1 (2008): 6. http://dx.doi.org/10.4102/sajpsychiatry.v14i1.83.

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<div style="left: 80.7408px; top: 404.406px; font-size: 15px; font-family: sans-serif; transform: scaleX(0.947259);" data-canvas-width="386.4817499999998">Interest in the subject of first-episode psychosis has increased</div><div style="left: 80.7408px; top: 427.746px; font-size: 15px; font-family: sans-serif; transform: scaleX(1.00913);" data-canvas-width="386.4972000000001">considerably in the last two decades. At present, a number</div><div style="left: 80.7408px; top: 451.086px; font-size: 15px; font-family: sans-serif; transform: scaleX(0.985844);" data-canvas-w
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Emsley, Robin, Piet P. Oosthuizen, Martin Kidd, Liezl Koen, Dana J. H. Niehaus, and H. Jadri Turner. "Remission in First-Episode Psychosis." Journal of Clinical Psychiatry 67, no. 11 (2006): 1707–12. http://dx.doi.org/10.4088/jcp.v67n1106.

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38

Schulz, S. Charles. "This issue: First-Episode Psychosis." Psychiatric Annals 45, no. 11 (2015): 545–46. http://dx.doi.org/10.3928/00485713-20151103-04.

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39

Power, Paddy. "Book Review: First Episode Psychosis." Australian & New Zealand Journal of Psychiatry 34, no. 4 (2000): 704–5. http://dx.doi.org/10.1080/j.1440-1614.2000.0765c.x.

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40

Arshad, P., M. Marcos, and B. Sridharan. "Hospitalisation in First-episode psychosis." British Journal of Psychiatry 180, no. 1 (2002): 84–85. http://dx.doi.org/10.1192/bjp.180.1.84.

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41

Vracotas, Nadia, and Ashok Malla. "Outcome in first-episode psychosis." International Clinical Psychopharmacology 26 (September 2011): e78-e79. http://dx.doi.org/10.1097/01.yic.0000405765.75220.34.

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42

Smith, Erin Murphy. "A first episode of psychosis." Nursing Made Incredibly Easy! 18, no. 4 (2020): 23–26. http://dx.doi.org/10.1097/01.nme.0000668368.84427.77.

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43

Lambert, Martin, Philippe Conus, Tim Lambert, and Pat D. McGorry. "Pharmacotherapy of first-episode psychosis." Expert Opinion on Pharmacotherapy 4, no. 5 (2003): 717–50. http://dx.doi.org/10.1517/14656566.4.5.717.

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McEVOY, JOSEPH P., JACKIE JOHNSON, DIANA PERKINS, et al. "Insight in first-episode psychosis." Psychological Medicine 36, no. 10 (2006): 1385–93. http://dx.doi.org/10.1017/s0033291706007793.

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Abstract:
Background. We report here a study examining the relationships between insight and psychopathology, cognitive performance, brain volume and co-morbid depression in 251 patients experiencing a first episode of psychosis, who were then randomly assigned to 2 years of double-blind treatment with either olanzapine or haloperidol.Method. Repeated measures of insight were obtained at baseline and 12, 24, 52 and 104 weeks by the Insight and Treatment Attitudes Questionnaire (ITAQ).Results. Older age, female gender and white ethnicity were associated with more insight. Higher total, positive, negative
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Clarke, Mary, Peter Whitty, Stephen Browne, et al. "Suicidality in first episode psychosis." Schizophrenia Research 86, no. 1-3 (2006): 221–25. http://dx.doi.org/10.1016/j.schres.2006.05.026.

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46

Nielssen, Olav B. "HOMICIDE IN FIRST EPISODE PSYCHOSIS." Schizophrenia Research 136 (April 2012): S23. http://dx.doi.org/10.1016/s0920-9964(12)70079-8.

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47

Skikic, Maja, and Jose Alberto Arriola. "First Episode Psychosis Medical Workup." Child and Adolescent Psychiatric Clinics of North America 29, no. 1 (2020): 15–28. http://dx.doi.org/10.1016/j.chc.2019.08.010.

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48

Achim, Amélie M., Rosalie Ouellet, Marc-André Roy, and Philip L. Jackson. "Mentalizing in first-episode psychosis." Psychiatry Research 196, no. 2-3 (2012): 207–13. http://dx.doi.org/10.1016/j.psychres.2011.10.011.

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Spencer, Elizabeth, Max Birchwood, and Dermot McGovern. "Management of first-episode psychosis." Advances in Psychiatric Treatment 7, no. 2 (2001): 133–40. http://dx.doi.org/10.1192/apt.7.2.133.

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Over recent years early intervention in psychosis has fired the imagination of clinicians and researchers, following the publication of several studies linking a long duration of psychosis prior to receiving treatment with a poor treatment outcome: a relationship that has been cogently argued to be independent of illness factors (e.g. Scully et al, 1997). Most influential was Wyatt's (1991) review of 22 studies, in which relatively similar groups of patients suffering from schizophrenia were, or were not, given antipsychotic medication early in the course of their illness. This pointed towards
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Hanevik, Hilde, Knut A. Hestad, Lars Lien, Inge Joa, Tor Ketil Larsen, and Lars Johan Danbolt. "Religiousness in First-Episode Psychosis." Archive for the Psychology of Religion 39, no. 2 (2017): 139–64. http://dx.doi.org/10.1163/15736121-12341336.

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The aim of the present study is to explore the significance of religiousness for patients suffering from first-episode psychosis. Our study is a thematic analysis. The study illustrates how the patients understood their hallucinations as mystical experiences. Even so, many of the patients describe their religiousness to be helpful in coping with their disorder, giving meaning to life as well as a relationship to a sacred figure. However, their religiousness often contained religious omnipotent delusions, and built on hallucinations, displayed an unsecure relationship to the sacred figure. From
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