Relevant bibliographies by topics / FISH, cathepsin K, target therapy

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  2. Dissertations / Theses

Academic literature on the topic 'FISH, cathepsin K, target therapy'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "FISH, cathepsin K, target therapy"

1

Caliò, Anna, Diego Segala, Enrico Munari, Matteo Brunelli, and Guido Martignoni. "MiT Family Translocation Renal Cell Carcinoma: from the Early Descriptions to the Current Knowledge." Cancers 11, no. 8 (2019): 1110. http://dx.doi.org/10.3390/cancers11081110.

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The new category of MiT family translocation renal cell carcinoma has been included into the World Health Organization (WHO) classification in 2016. The MiT family translocation renal cell carcinoma comprises Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring TFEB gene fusion. At the beginning, they were recognized in childhood; nevertheless, it has been demonstrated that these neoplasms can occur in adults as well. In the nineties, among Xp11 renal cell carcinoma, ASPL, PRCC, and SFPQ (PSF) were the first genes recognized as partners
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2

Stoch, SA, and JA Wagner. "Cathepsin K Inhibitors: A Novel Target for Osteoporosis Therapy." Clinical Pharmacology & Therapeutics 83, no. 1 (2007): 172–76. http://dx.doi.org/10.1038/sj.clpt.6100450.

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3

Caliò, Anna, Matteo Brunelli, Stefano Gobbo, et al. "Cathepsin K: A Novel Diagnostic and Predictive Biomarker for Renal Tumors." Cancers 13, no. 10 (2021): 2441. http://dx.doi.org/10.3390/cancers13102441.

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Cathepsin K is a papain-like cysteine protease with high matrix-degrading activity. Among several cathepsins, cathepsin K is the most potent mammalian collagenase, mainly expressed by osteoclasts. This review summarizes most of the recent findings of cathepsin K expression, highlighting its role in renal tumors for diagnostic purposes and as a potential molecular target. Indeed, cathepsin K is a recognized diagnostic tool for the identification of TFE3/TFEB-rearranged renal cell carcinoma, TFEB-amplified renal cell carcinoma, and pure epithelioid PEComa/epithelioid angiomyolipoma. More recentl
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4

Marchand-Adam, Sylvain, Marion Pronost, Ahlame Saidi, Fabien Lecaille, and Gilles Lalmanach. "Cathepsin K: both a likely biomarker and a new therapeutic target in lymphangioleiomyomatosis?" Rare Disease and Orphan Drugs Journal 2, no. 1 (2023): 3. http://dx.doi.org/10.20517/rdodj.2022.24.

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Lymphangioleiomyomatosis (LAM) is a rare disease which is characterized by cystic lung destruction and lymphangiomas, and is associated with a high risk of osteoporosis-related bone fractures. Its diagnosis is based on pulmonary anatomopathological criteria combined with chest computed tomography. VEGF-D is the only serum diagnostic biomarker used in clinic, while inhibition of the mTOR pathway by rapamycin is currently the only reference therapy for LAM. Human cathepsin K (CatK), a potent collagenase predominantly found in osteoclasts, is considered as a valuable target for anti-osteoporosis
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5

Gao, B., W. Chen, L. Hao, et al. "Inhibiting Periapical Lesions through AAV-RNAi Silencing of Cathepsin K." Journal of Dental Research 92, no. 2 (2012): 180–86. http://dx.doi.org/10.1177/0022034512468757.

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Dental caries, one of the most prevalent infectious diseases worldwide, affects approximately 80% of children and the majority of adults. Dental caries may result in endodontic disease, leading to dental pulp necrosis, periapical inflammation and bone resorption, severe pain, and tooth loss. Periapical inflammation may also increase inflammation in other parts of the body. Although many studies have attempted to develop therapies for this disease, there is still an urgent need for effective treatments. In this study, we applied a novel gene therapeutic approach using recombinant adeno-associat
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6

Weicker, Sean, Wanda Cromlish, Sonia Lamontagne, et al. "Cathepsin S in a Murine Model of Allergic Asthma (B108)." Journal of Immunology 178, no. 1_Supplement (2007): LB22—LB23. http://dx.doi.org/10.4049/jimmunol.178.supp.b108.

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Abstract Cathepsin S (Cat S), expressed predominately on antigen presenting cells, has been proposed as a therapeutic target for asthma. We used genetic and pharmacological tools to investigate the role of Cat S in murine models of allergic asthma. Mice null for Cat S were protected from OVA-induced pulmonary inflammation, but exhibited no protection from OVA-induced airway hyper-reactivity. To determine the role of Cat S during the challenge phase, we identified a potent and selective Cat S inhibitor, Compound A (Cpd A, IC50 mCat S = 0.6 nM, ≥470 fold selective vs mCat B, K, L), which inhibit
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7

Tchetina, E., G. Markova та A. Satybaldyev. "AB0183 DOWNREGULATION OF TUMOUR NECROSIS FACTOR α GENE EXPRESSION IN CULTURED PERIPHERAL BLOOD MONONUCLEAR CELLS IN THE PRESENCE OF TOFACITINIB PRIOR TO THERAPY AS A PROGNOSTIC BIOMARKER OF CLINICAL REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH TOFACITINIB". Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1221.1–1221. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2578.

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BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia, mononuclear cell infiltration, bone erosion and joint destruction. Recently we have shown that changes in energy generation-related gene expressions in the peripheral blood of tofacitinib (TOFA)-naïve patients with RA are associated with clinical response to treatment [1]. Therefore, considering metabolic status of patients with RA, may be useful for identification of prognostic biomarkers for personal responsiveness to TOFA therapy in TOFA-naïve RA patients by baseline gene expression
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8

Wang, Tong, Yan Guo, Xiao-Wei Shi, et al. "Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway." Evidence-Based Complementary and Alternative Medicine 2021 (April 26, 2021): 1–17. http://dx.doi.org/10.1155/2021/8168657.

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Subchondral bone lesions, as the crucial inducement for accelerating cartilage degeneration, have been considered as the initiating factor and the potential therapeutic target of knee osteoarthritis (KOA). Acupotomy, the biomechanical therapy guided by traditional Chinese meridians theory, alleviates cartilage deterioration by correcting abnormal mechanics. Whether this mechanical effect of acupotomy inhibits KOA subchondral bone lesions is indistinct. This study aimed to investigate the effects of acupotomy on inhibiting subchondral bone resorption and to define the possible mechanism in immo
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Zeisbrich, Markus, Rolando E. Yanes, Hui Zhang, et al. "Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation." Annals of the Rheumatic Diseases 77, no. 7 (2018): 1053–62. http://dx.doi.org/10.1136/annrheumdis-2017-212647.

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ObjectivesAccelerated atherosclerotic disease typically complicates rheumatoid arthritis (RA), leading to premature cardiovascular death. Inflammatory macrophages are key effector cells in both rheumatoid synovitis and the plaques of coronary artery disease (CAD). Whether both diseases share macrophage-dependent pathogenic mechanisms is unknown.MethodsPatients with RA or CAD (at least one myocardial infarction) and healthy age-matched controls were recruited into the study. Peripheral blood CD14+ monocytes were differentiated into macrophages. Metabolic profiles were assessed by Seahorse Analy
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10

Gai, Dongzheng, Stewart JP, Xuxing Shen, et al. "CST6 Is a Small Autocrine Molecule That Targets Myeloma Growth and Bone Destruction." Blood 136, Supplement 1 (2020): 21. http://dx.doi.org/10.1182/blood-2020-140568.

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Bone destruction is a major complication of multiple myeloma (MM). Healthy bone is constantly remodeled through bone resorption by osteoclasts and bone formation by osteoblasts. New bone formation in MM is virtually non-existent, because differentiation of osteoblasts is inhibited by DKK1, a Wnt-β-catenin signaling inhibitor secreted by MM cells, reported by our group in NEJM, 2003. MM in its early stages is totally dependent on its microenvironment and for the hyperdiploid type MM this dependence is perpetual. Based on concordant gene expression signatures, predominantly driven by recurrent t
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Dissertations / Theses on the topic "FISH, cathepsin K, target therapy"

1

Caliò, Anna. "MiT family translocation renal cell carcinoma: looking for diagnostic and druggable markers." Doctoral thesis, 2019. http://hdl.handle.net/11562/994945.

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Renal cell carcinomas with chromosome translocation are rare neoplasms which often occur in young patients. In the last World Health Organization (WHO 2016) are named as MiT family translocation renal cell carcinoma comprising two different entities: Xp11 renal cell carcinoma and t(6;11) renal cell carcinoma. Recently, renal cell carcinomas with TFEB amplification has been described in connection with t(6;11) renal cell carcinoma. We analyzed 30 MiT family translocation renal cell carcinoma and 2 renal cell carcinomas with TFEB amplification collecting data on clinical, histological, immunohis
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