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Dissertations / Theses on the topic 'Fission yeast'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Mata, Monteagudo Juan Ignacio. "Fission yeast cell polarity." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265407.

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2

Spink, Karen Gillian. "Telomeric proteins in fission yeast." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312057.

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3

Hansen, Karen. "3' end formation in fission yeast." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389053.

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4

Beck, Timothy Joseph. "A phenotype ontology for fission yeast." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488618.

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This work examines the suitability of two different ontology approaches for the annotation of Schizosaccharomyces pombe (fission yeast) phenotypes derived from a number of screens of two fission yeast strain libraries- a temperature-sensitive library and an insertional library.

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5

Woollard, Alison. "Cell cycle control in fission yeast." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318479.

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6

Abbott, Johanna. "Novel kinetochore factors in fission yeast." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11825.

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The fission yeast centromere is packaged as transcriptionally silent heterochromatin which serves as a platform for kinetochore assembly. The centromere consists of two distinct domains; the outer repeats and the central core. It has been shown previously that these regions associate with distinct sets of proteins, for example, the fission yeast homologue of CENP-A, Cnp1p, is present at the central core, together with Mis6 and Mis12, whilst the heterochromatin protein Swi6 associates with the outer repeats. Marker genes placed in the centromere are transcriptionally silenced. This feature of t

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7

Atkinson, S. R. "The fission yeast non-coding transcriptome." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1457868/.

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Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression, although it remains unclear to what extent they contribute overall to the information flow from genotype to phenotype. Using strand-specific RNAsequencing, I identify thousands of novel unstable, or cryptic, lncRNAs in Schizosaccharomyces pombe. The nuclear exosome, the RNAi pathway and the cytoplasmic exonuclease Exo2 represent three key pathways regulating lncRNAs in S. pombe, defining the overlapping classes of CUTs, RUTs and XUTs, respectively. The nuclear exosome and the RNAi pathway act cooperatively

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8

Scheffler, Kathleen. "Microtubule-dependent nuclear congression in fission yeast and a novel factor in cellular morphogenesis of fission yeast." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066510/document.

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(I) J'ai étudié les mécanismes contrôlant la congression des noyaux pendant la conjugaison de la levure S. pombe. A l'aide d'imagerie à long terme basée sur la microfluidique, j'ai mesuré la durée précise de la congression nucléaire et démontré que deux moteurs moléculaires des MTs, la dynéine et la kinésine-14 Klp2 contribuent à ce processus, dans des voies parallèles. La dynéine s’associe aux SPBs. Son niveau au SPB dépend de la chaine légère intermédiaire Dli1 qui pourrait potentiellement stabiliser le complexe dynéine et est requise pour la congression. Klp2 se localise sur les MTs. La loc

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9

Scheffler, Kathleen. "Microtubule-dependent nuclear congression in fission yeast and a novel factor in cellular morphogenesis of fission yeast." Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066510.pdf.

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(I) J'ai étudié les mécanismes contrôlant la congression des noyaux pendant la conjugaison de la levure S. pombe. A l'aide d'imagerie à long terme basée sur la microfluidique, j'ai mesuré la durée précise de la congression nucléaire et démontré que deux moteurs moléculaires des MTs, la dynéine et la kinésine-14 Klp2 contribuent à ce processus, dans des voies parallèles. La dynéine s’associe aux SPBs. Son niveau au SPB dépend de la chaine légère intermédiaire Dli1 qui pourrait potentiellement stabiliser le complexe dynéine et est requise pour la congression. Klp2 se localise sur les MTs. La loc

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10

Moldón, Vara Alberto. "Promoter-driven splicing regulation in fission yeast." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7125.

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The meiotic cell cycle is modified from the mitotic cell cycle by having a premeiotic S phase which leads to high levels of recombination, two rounds of nuclear division with no intervening DNA synthesis, and a reductional pattern of chromosome segregation. Rem1 is a cyclin that is expressed only during meiosis in the fission yeast Schizosaccharomyces pombe. Cells in which rem1 has been deleted show a decreased intragenic meiotic recombination and a delay at the onset of meiosis I. When ectopically expressed in mitotically growing cells, Rem1 induces a G1 arrest followed by severe mitotic cata

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11

SAKALAR, Cagri. "Roles of H2A.z in Fission Yeast Chromatin." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1195137345841-32085.

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Covalent histone modifications such as methylation, acetylation as well as differential incorporation of histone variants are shown to coincide with different chromatin compartments and mark active or repressed genes. Msc1 is one of the seven JmjC Domain Proteins (JDPs) in Fission Yeast. JDPs are known to function in chromatin and some act as histone demethylases. We found that Msc1 is a member of Swr1 Complex which is known to exchange histone H2A variant H2A.z in nucleosomes. We purified H2A.z as a member of Swr1 Complex and its interaction with Swr1 Complex depends on Swr1. We’ve shown that

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12

Ocampos, Maristela. "A study of arginase in fission yeast." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388437.

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13

Heichinger, Christian. "Characterisation of fission yeast DNA replication origins." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444737/.

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In many eukaryotic organisms the chromosomal origins of DNA replication (ORIs) are not characterised by a clearly defined consensus sequence. In this thesis using the fission yeast, for the first time I have carried out a genome-wide analysis to identify such ORIs during the mitotic and meiotic cell cycles. The data can be summarised as follows: a total of 401 ORIs were identified which were used 29 percent of the time during mitotic S-phase and were spaced every 31 kilobases (kb) on average. The same ORIs were used during pre-meiotic S-phase although with lower efficiency in most chromosomal

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14

Stern, Bodo. "Control of G1 progression in fission yeast." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264166.

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15

May, Karen Marie. "Molecular characterisation of fission yeast myosin II." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263251.

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16

Al-Harithy, Rowyda Nawwaf. "Characterization of the fission yeast rad2 gene." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239575.

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17

De, Sandip. "Tracking translation factors in fission yeast nucleus." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1421/.

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Translation factors are essential components of the ribosome, yet it has been reported that many ribosomal proteins (RPs) and other translation factors are found at transcription sites of Drosophila melanogaster (D. melanogaster) polytene chromosomes. Whilst these findings might indicate the presence of ribosomal subunits at transcription sites, it has also been reported that these proteins associate with non-coding RNA in Saccharomyces cerevisiae (S. cerevisiae), suggesting that their localization with transcription sites reflects their non-ribosomal function. However, the functional signific

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18

Lackner, Daniel H. "Genome-wide translational control in fission yeast." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611872.

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19

Dunleavy, Elaine. "Assembly of centromeric chromatin in fission yeast." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/13739.

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Fission yeast centromeres are composed of a central domain surrounded on both sides by outer repeat heterochromatin. Marker genes inserted within the central domain or the outer repeats are transcriptionally silenced. A screen performed to identify mutants that specifically alleviate silencing at the central domain, identified the <i>sim</i> (silencing in the middle of the centromere) mutants. The <i>sim6</i> mutant was unusual in that it was found to alleviate both central domain and outer repeat silencing and suggests that there may be cross talk between kinetochore assembly and the integrit

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20

Sczaniecka, Matylda. "Analysis of anaphase inhibitors in fission yeast." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/14371.

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As a result of checkpoint activation, a signalling cascade is initiated and a number of complexes between the checkpoint components are formed. This leads to the inhibition of the Anaphase Promoting Complex (APC), which is the ubiquitin ligase responsible for targeting mitotic proteins: securing and cyclin B for degradation by the 26S proteasome. The complexes formed include the MCC, or Mitotic Checkpoint Complex, which in fission yeast (Schizosaccharomyces pombe) consists of Mad2, Mad3 checkpoint proteins together with the APC activator, Slp1 (the Cdc20 homologue). The MCC has been shown to b

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21

Almeida, Hugo Ricardo Noronha de. "Measuring chromosome-end fusions in fission yeast." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2013. http://hdl.handle.net/10362/10629.

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Dissertation presented to obtain the Ph.D degree in Molecular Biology<br>The ends of eukaryotic chromosomes are protected from illegitimate repair by structures called telomeres. These are comprised of specific DNA repeats bound by a specialized protein complex. When telomere function is compromised, chromosome ends fuse, generating chromosomal abnormalities and genomic instability.(...)

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22

Schmidt, Michael. "Regulation of protein turnover in fission yeast." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-36654.

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23

Stone, Miranda Lucy. "Proteasome-associated deubiquitinating enzymes in fission yeast." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23210.

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Two putative proteasome-associated DUBs were identified in <i>S. pombe. </i>Uch2 had previously been suggested to copurify and colocalise with the proteasome (Li et al., 2000). A second DUB, Ubp6, was identified in a sequence homology search for S. pombe proteins containing a ubiquitin-like (Ubl) domain (C. Semple and C. Gordon, unpublished). This domain has been shown to mediate interactions with the proteasome, implying that Ubp6 might also be proteasome-associated (Wilkinson et al., 2001). In the first part of this study, both Uch2 and Ubp6 are shown to be proteasome-associated DUBs. The <i

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24

Doe, Claudette Louise. "Characterisation of the fission yeast rad8 gene." Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357682.

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25

Edelmaier, Christopher. "Computational Modeling of Mitosis in Fission Yeast." Thesis, University of Colorado at Boulder, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10837613.

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<p> Mitosis ensures the proper segregation of chromosomes into daughter cells, which is accomplished by the mitotic spindle. During fission yeast mitosis, chromosomes establish bi-orientation as the bipolar spindle assembles, meaning that sister kinetochores become attached to microtubules whose growth was initiated by the two sister poles. This process includes mechanisms that correct erroneous attachments made by the kinetochores during the attachment process. This thesis presents a 3D physical model of spindle assembly in a Brownian dynamics-kinetic Monte Carlo simulation framework and a re

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26

Kristell, Carolina. "Chromatin Dynamics in the Fission Yeast, Schizosaccharomyces pombe." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158084.

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In the eukaryotic cell nucleus, spatial organization and dynamics of the genome is important in the regulation of gene expression. This thesis describes the use of the fission yeast, Schizosaccharomyces pombe, to study chromatin regulation and dynamics. We used nitrogen starvation to induce transcription of genes in fission yeast cells. In induced genes, nucleosomes get evicted in both the promoter and in the open reading frame (ORF). In the genes with the highest expression more nucleosomes get evicted from the ORF than from the promoter. This indicates that large rearrangements of the chroma

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27

Fersht, N. "The checkpoint role of Cdc18 in fission yeast." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445447/.

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The highly conserved eukaryotic checkpoints keep tight control over cell cycle progression, arresting the cell in response to incomplete DNA replication or DNA damage. In fission yeast, Rad3 (functional homologue of ATM, mutated in ataxia telangiectasia, and structural homologue of ATR, ataxia telangiectasia and rad3 related) is necessary for activation of both replication and damage checkpoints. However, despite the identification of many checkpoint genes, the actual sequence of upstream events leading to Rad3 activation remains unclear. The aim of my project was to identify and characterise

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28

Raponi, Mitch Biochemistry &amp Molecular Genetics UNSW. "Antisense RNA-mediated gene silencing in fission yeast." Awarded by:University of New South Wales. Biochemistry and Molecular Genetics, 2001. http://handle.unsw.edu.au/1959.4/18277.

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The major aims of this thesis were to investigate the influence of i) antisense gene location relative to the target gene locus (?????location effect?????), ii) double-stranded RNA (dsRNA) formation, and iii) over-expression of host-encoded proteins on antisense RNA-mediated gene regulation. To test the location effect hypothesis, strains were generated which contained the target lacZ gene at a fixed location and the antisense lacZ gene at various genomic locations including all arms of the three fission yeast chomosomes and in close proximity to the target gene locus. A long inverse-PCR proto

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29

Bond, Michael Edward. "Ras signalling in the fission yeast Schizosaccharomyces pombe." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/46013/.

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Ras signalling is vital to many cellular processes. Ras proteins mediate a vast array of cellular signalling networks, and are conserved from humans to unicellular eukaryotes. The study of ras signalling in higher eukaryotes presents a number of technical challenges, due to the presence of multiple ras isoforms, regulatory proteins and activators. The fission yeast Sz. pombe represents an ideal system for the investigation of ras signalling, as it contains a single, nonessential ras protein (Ras1). In addition, Ras1 is involved in the regulation of a number of downstream pathways. A number of

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30

Schmidt, C. K. "Genomic analysis of cohesin dynamics in fission yeast." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/14917/.

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Cohesin holds sister chromatids together and facilitates their accurate segregation in mitosis. Little is known about how and where cohesin binds to chromosomes. Recent genome-wide investigations have led to apparent disparities between different model organisms. In this thesis, analysis of the cohesin binding pattern reveals that several determinants, thought specific for distinct organisms, collectively define the overall distribution of cohesin along fission yeast chromosomes. Like in budding yeast, cohesin is mainly detected at sites of convergent transcriptional termination, in the follow

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31

Hogan, C. "Functional characterisation of the fission yeast Ino80 complex." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604143.

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INOsitol-requiring 80 (Ino80) is a catalytic ATP-dependent nucleosome remodelling enzyme of the Ino80 complex which is involved in transcription, replication and the DNA damage response. In this thesis, I characterise for the first time the Ino80 complex from <i>Schizosaccharomyces pombe.</i> Purification of the Ino80-associated complex identified a highly conserved complex and the presence of a novel zinc finger protein, lec1, with similarities to the mammalian transcriptional regulator Yin Yang 1 (YY1) and other members of the GLI-Krüppel family of proteins. Deletion of this lec1 protein or

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32

Amoah-Buahin, Evelyn. "Hyphal growth in the fission yeast Schizosaccharomyces pombe." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430364.

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33

Baum, Benjamin. "Control of S-phase transcription in fission yeast." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265313.

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34

Samuel, Margaret Jane. "Novel regulators of the fission yeast cell cycle." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272174.

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35

Riaz, Abida. "Cyclin B in fission yeast mitosis and meiosis." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286160.

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36

Behrens, Ralf. "Molecular mechanisms of cell polarity in fission yeast." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271825.

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37

Armes, Helen Elizabeth Harcourt. "Implementing super-resolution palm microscopy in fission yeast." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/67027/.

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Fluorescence microscopy is a popular biological technique because it allows the study of cells in great detail. However, the resolution achievable is limited by the diffraction properties of light, meaning that fine detail cannot be resolved. Various super-resolution microscopy methods have been developed to break this resolution limit. This thesis focuses on the single molecule localisation microscopy techniques. My host laboratory focuses on DNA replication and repair pathways using the model organism Schizosaccharomyces pombe (fission yeast). The aim of this thesis is thus to apply the tech

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38

Abraham, Anne. "Polo-like kinase interacting proteins in fission yeast." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/10699.

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Kms1 and Kms2 are important for integrity of the SPB. To find the biological significance of the interactions between Plo1 and these SPB proteins, attempts were made to disrupt the interaction by mutations. For this purpose, firstly regions responsible for the interaction were identified, and then mutations were made in the SPB proteins by random mutagenesis of this region. For Sid4, I isolated two point mutations, which had greatly weakened interaction with Plo1. To study the effect of disrupting the interaction <i>in vivo, </i>the two <i>sid4</i> mutants were expressed from a fission yeast p

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39

Almeida, Ricardo. "RNA interference and heterochromatin formation in fission yeast." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/11198.

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There is strong evidence suggesting that RNAi acts co-transcriptionally in order to promote heterochromatin formation. Thus, it is possible that RITS activity is interlinked with transcription-related processes such as cleavage/poly-adenylation, transcription termination and RNA turnover by the exosome complex. In order to investigate this hypothesis, the integrity of RNAi and heterochromatin was assayed in mutants for factors that are involved in all three pathways. Mutations on <i>dhp1 </i>(termination),<i> pfs2 </i>(cleavage and polyadenylation) <i>dis3 </i>and <i>rrp6</i> (exosome) had neg

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40

McInerny, Christopher. "Control of S-phase genes in fission yeast." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/12615.

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The work described in this thesis uses the fission yeast <i>Schizosaccharomyces pombe</i> as model system to analyse the molecular processes that control passage through the G<SUB>1</SUB> and S-phases of the cell-cycle. In particular, the work analyses the control of expression of <i>cdc22</i><SUP>+</SUP>, a gene whose transcript varies in abundance during the cell cycle with a maximum at the G<SUB>1</SUB>-S phase boundary. Chapter two describes the sequencing of <i>cdc22</i><SUP>+</SUP> and shows it encodes the large subunit of ribonucleotide reductase, an enzyme required for DNA precursor me

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41

Lord, Phillip. "Genes affecting the centromeres of the fission yeast." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/15235.

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In the fission yeast, <I>S. pombe</I> the centromeres have been extensively characterised, and consist of a largely unique central core, surrounded by a large inverted repeat. Previous studies have shown that marker genes inserted into these regions are transcriptionally silenced. Several genes have been isolated which are required for this transcriptional silencing. One of these, <I>swi6*</I>, has been shown to localise to the centromere <I>in vivo </I>and it thought to form part of the functional kinetochore. In this thesis I describe the first molecular characterisation of another gene, <I>

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42

Richardson, Kathryn. "Mechanisms of GPCR signal regulation in fission yeast." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/63554/.

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Cells communicate with each other and respond to environmental cues by sending and receiving signals. Many external signals (ligands) are detected through G protein-coupled receptors (GPCRs), a major class of transmembrane proteins. GPCRs transduce these external signals into appropriate intracellular responses, enabling the cell to adapt to its environment. Malfunctions in these signalling pathways can lead to a range of human diseases and hence GPCRs have become attractive candidates for pharmacological design. The activation of a single receptor has the ability to induce numerous intracellu

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43

Cantwell, Helena Rose. "Nuclear size control and homeostasis in fission yeast." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10054466/.

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Despite it being recognised as a problem worthy of consideration over a century ago, we have little mechanistic understanding of how the size of a cell’s nucleus is determined. The simply shaped fission yeast Schizosaccharomyces pombe is genetically tractable and undergoes a closed mitosis, making it a useful system in which to probe mechanisms of nuclear size control. In S. pombe cells, nuclear volume scales with cell volume, and not DNA content, across a wide range of cell volumes and throughout the cell cycle, maintaining a constant nuclear volume to cell volume (N/C) ratio. This thesis exp

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44

Feret, Dorota. "Proteasomal control of the fission yeast microtubule cytoskeleton." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.704739.

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45

Patch, Ann-Marie. "A comparative analysis of tandem repeats in the fission yeast and budding yeast genomes." Thesis, University of Exeter, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425493.

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46

Dolan, William P. "Molecular genetic analysis of the fission yeast hsk1⁺ kinase /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189214.

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47

Yin, Ling. "Activation of DNA Replication Initiation Checkpoint in Fission Yeast." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/194.

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In the fission yeast, Schizosacchromyces pombe, blocks to DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the Cds1 kinase. Cds1 is required to both stabilize stalled replication forks and to prevent premature entry into mitosis. Interestingly, although Cds1 is essential to maintain the viability of mutants defective in DNA replication elongation, my study shows that mutants defective in DNA replication initiation require the Chk1 kinase, rather than Cds1. This suggests that failed initiation events can lead to activation of the DNA damage checkpo

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48

Labib, Karim. "Regulation of S-phase and mitosis in fission yeast." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358653.

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49

Ors, Aslihan. "Identification of novel APC/C regulators in fission yeast." Thesis, Institute of Cancer Research (University Of London), 2009. http://publications.icr.ac.uk/10297/.

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Sequential degradation of cell cycle proteins is a major regulatory mechanism for proper cell proliferation. Turnover of these proteins is performed by the ubiquitin/proteasome pathway, which poly-ubiquitylates and subsequently degrades the target proteins. The anaphase-promoting complex/cyclosome (APC/C) is a multi subunit E3 ubiquitin ligase that provides substrate specificity and regulation of the ubiquitin pathway. Two of the most important substrates are Cut2/securin and Cdc13/cyclin B, enabling chromosome segregation and exit from mitosis, respectively. Since APC/C function is very impor

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50

Ananthanarayanan, Vaishnavi. "Dynein dynamics during meiotic nuclear oscillations of fission yeast." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135620.

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Cytoplasmic dynein is a ubiquitous minus-end directed motor protein that is essential for a variety of cellular processes ranging from cargo transport to spindle and chromosome positioning. Specifically, in fission yeast during meiotic prophase, the fused nucleus follows the spindle pole body in oscillatory movements from one cell pole to the other. The three molecular players that are essential to this process are: (i) the motor protein dynein, which powers the movement of the nucleus, (ii) microtubules, which provide the tracts for the movement and (iii) Num1, the anchor protein of dynein at

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