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Relevant bibliographies by topics / Five-membered heterocycles

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Academic literature on the topic 'Five-membered heterocycles'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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Journal articles on the topic "Five-membered heterocycles"

1

Rusu, Aura, Ioana-Maria Moga, Livia Uncu, and Gabriel Hancu. "The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy." Pharmaceutics 15, no. 11 (2023): 2554. http://dx.doi.org/10.3390/pharmaceutics15112554.

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Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug. These properties can affect the drug’s activity spectrum, potency, and pharmacokinetic and toxicological properties. Using scientific databases, we identified and discussed the antibacterials used in therapy, containing five-membered heterocycles in their molecular structure. The identified five-membered heterocycles used in antibacterial design contai

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Drapak, І. V. "In silico screening of drug-like molecules for the treatment of cardiovascular diseases on the basis of five-membered privileged heterocycles." Farmatsevtychnyi zhurnal, no. 4 (September 10, 2019): 61–72. http://dx.doi.org/10.32352/0367-3057.4.19.07.

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Among various heterocyclic systems, the derivatives of five-membered heterocycles are of special interest. Most of the above mentioned heterocycles are treatred as so-called privileged structures in modern medicinal chemistry. In silico screening among five-membered heterocycles of molecules for the treatment of cardiovascular diseases is actual. The aim of the work was the search for synthetic drug-like molecules based on functionalized five-membered heterocycles and related heterocyclic systems as an element of the theoretical platform for rational design of compounds acting on the car

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Maji, Pradip Kumar. "Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview." Current Organic Chemistry 23, no. 20 (2019): 2204–69. http://dx.doi.org/10.2174/1385272823666191019111627.

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This review describes the non-exhaustive scenery of the synthesis of various biologically interesting pyrimidine annulated five-membered heterocyclic ring systems that have been appeared in the literature during the last two decades. During this period, different synthetic routes and various methodologies have been developed for the functionalization of pyrimidine ring towards the construction of five-membered heterocyclic rings. The aim of this review is to give an overview of the assorted methodologies that have been reported about the chemistry of construction of pyrimidines annulated nitro

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Kinjo, Rei, and Bochao Su. "Construction of Boron-Containing Aromatic Heterocycles." Synthesis 49, no. 14 (2017): 2985–3034. http://dx.doi.org/10.1055/s-0036-1588832.

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Boron-containing aromatic systems exhibit unique electronic properties and reactivities that have been extensively studied for a long time. This review highlights the recent developments in the synthesis of aromatic boron-containing heterocycles. The organization of the contents is based on the sizes of rings and the heteroatoms other than boron. Early work in the field is briefly introduced, but the main focus is on recent reports published during the period of 2008 through 2016.1 Introduction2 Five-Membered Rings2.1 Borole Derivatives2.2 B,N-Heterocycles2.3 B,O-Heterocycles3 Six-Membered Rin

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Shtefan, E. D., and V. Yu Vvedenskii. "The tautomerism of heterocyclic thiols. Five-membered heterocycles." Russian Chemical Reviews 65, no. 4 (1996): 307–14. http://dx.doi.org/10.1070/rc1996v065n04abeh000212.

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6

Sadekov, Igor D., Gasan M. Abakarov, Yekaterina I. Sadekova, and Vladimir I. Minkin. "Five-Membered Tellurium-Containing Heterocycles." Sulfur reports 6, no. 1 (1986): 15–64. http://dx.doi.org/10.1080/01961778608082490.

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Kashima, Choji, Shigeki Hibi, Tatsuya Maruyama, Kazuo Harada, and Yoshimori Omote. "Ozonolysis of five-membered heterocycles." Journal of Heterocyclic Chemistry 24, no. 3 (1987): 637–39. http://dx.doi.org/10.1002/jhet.5570240318.

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El-Sawy, Eslam Reda, Ahmed Bakr Abdelwahab та Gilbert Kirsch. "Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part II: Five-Membered Aromatic Rings with Multi Heteroatoms". Molecules 26, № 11 (2021): 3409. http://dx.doi.org/10.3390/molecules26113409.

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Coumarins are natural heterocycles that widely contribute to the design of various biologically active compounds. Fusing different aromatic heterocycles with coumarin at its 3,4-position is one of the interesting approaches to generating novel molecules with various biological activities. During our continuing interest in assembling information about fused five-membered aromatic heterocycles, and after having presented mono-hetero-atomic five-membered aromatic heterocycles in Part I. The current review Part II is intended to present an overview of the different synthetic routes to coumarin (be

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Sbei, Najoua, Anna V. Listratova, Alexander A. Titov, and Leonid G. Voskressensky. "Recent Advances in Electrochemistry for the Synthesis of N-Heterocycles." Synthesis 51, no. 12 (2019): 2455–73. http://dx.doi.org/10.1055/s-0037-1611797.

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The construction of N-heterocyclic rings represents a very important and fast-developing area of organic synthesis. In this context, electrochemistry has emerged as a mild solution for generating in situ the required electrophilic substrates, bases and nucleophiles derived from low-level and extremely stable reagents, the further application of which makes some heterocycles more accessible. In this review, we have covered the recent advances in the electrochemical synthesis of five- and six-membered N-heterocyclic compounds published from 2017 to October 2018.1 Introduction2 Electrochemical Sy

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10

Angeli, Andrea, Niccolò Paoletti, and Claudiu T. Supuran. "Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors." Molecules 28, no. 7 (2023): 3220. http://dx.doi.org/10.3390/molecules28073220.

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The development of heterocyclic derivatives has progressed considerably over the past decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular, five-membered heterocyclic sulfonamides have been generally shown to be more effective inhibitors compared to six-membered rings ones. Despite the importance of oxygen and nitrogen five-membered heterocyclic aromatic rings in medicinal chemistry, the installation of sulfonamide moiety on such heterocycles has not received much attention. On the other hand, 1,3,4-thiadiazole/thiadiazoline ring-bearing sulfonamides a

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Dissertations / Theses on the topic "Five-membered heterocycles"

1

Barcock, Richard. "Five-membered heterocycles : metallation studies and azafulvenes." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293721.

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Na, Hai-Sub. "Synthesis and functionalization of five-membered heterocycles-containing conjugated polymers." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/136247.

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Granitzka, Markus. "Aggregation Study on Lithiated Five-membered Heterocycles – Towards the Pentuple Ion." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-5E0A-C.

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Gentili, Denis <1982&gt. "Synthesis of five-membered heterocycles and of nanostructured systems for nanomedicine applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2461/1/Gentili_Denis_tesi.pdf.

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Gentili, Denis <1982&gt. "Synthesis of five-membered heterocycles and of nanostructured systems for nanomedicine applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2461/.

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Armani, Simone. "Five-membered heterocycles as novel molecular scaffolds for targeting triple hydrogen bonding interactions." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/5431.

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2009/2010<br>Due to its prominent directionality and strength, H-bonds are ones of the most widely used non-covalent interactions in supramolecular chemistry. Despite its relative high strength (energy of an H-bond in the gas phase typically ranges between 0−5 Kcal mol−1) in comparison with other non-covalent interactions, association of two molecules by means of a single H-bond leads to complexes displaying low thermodynamical stabilities, thus limiting their exploitation in the non-covalent synthesis of functional materials for real-world applications. Thereby, when stronger interactions are

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D'Oyley, J. M. "Synthesis of five-membered heterocycles : novel allosteric modulators for nicotinic receptors and new gold-catalysed reactions." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1455536/.

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The Drug Discovery project is centred on the design, synthesis and characterisation of novel positive allosteric modulators (PAMs) for α7 nicotinic receptors (nAChR). These receptors are widely found in the central and peripheral nervous systems and are involved in a range of physiological processes. They are active targets for the treatment of pain as well as psychiatric and neurodegenerative disorders. Nicotinic receptors are ion channels which open and allow ions to flow in or out of the neuron upon binding of an agonist. Positive allosteric modulators (PAM) enhance the receptor’s response

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Granitzka, Markus [Verfasser], Dietmar [Akademischer Betreuer] Stalke, George M. [Akademischer Betreuer] Sheldrick, et al. "Aggregation Study on Lithiated Five-membered Heterocycles – Towards the Pentuple Ion / Markus Granitzka. Gutachter: Dietmar Stalke ; George M. Sheldrick ; Heidrun Sowa ; Thomas Dr. Waitz ; Inke Siewert ; Ulf Diederichsen. Betreuer: Dietmar Stalke." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1046987224/34.

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Granitzka, Markus Verfasser], Dietmar [Akademischer Betreuer] Stalke, George M. [Akademischer Betreuer] Sheldrick, et al. "Aggregation Study on Lithiated Five-membered Heterocycles – Towards the Pentuple Ion / Markus Granitzka. Gutachter: Dietmar Stalke ; George M. Sheldrick ; Heidrun Sowa ; Thomas Dr. Waitz ; Inke Siewert ; Ulf Diederichsen. Betreuer: Dietmar Stalke." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://nbn-resolving.de/urn:nbn:de:gbv:7-11858/00-1735-0000-0022-5E0A-C-5.

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Amine, Maria El. "Heterocycles germanies : synthese, reactivite, nouvelles voies d'acces aux especes du germanium a coordinence non usuelle." Toulouse 3, 1987. http://www.theses.fr/1987TOU30202.

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Ce travail concerne l'etude d'heterocycles germanies precurseurs d'especes du germanium tricoordine. La premiere partie est consacree a une mise au point bibliographique concernant les especes a germanium doublement lie. La deuxieme partie concerne l'etude des reactions de thermolyse, pyrolyse et photolyse de thiagermetannes-3,1 photolyse de dithiagermolannes-2,4,1 et pyrolyse de dioxydes-3,3 de thiagermetannes-3,1 qui font intervenir des intermediaires et de nouvelles especes du germanium pi lie, les sulfenes. Cette partie concerne egalement des tentatives de synthese du dimethyl-1,1 oxagerme

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Books on the topic "Five-membered heterocycles"

1

Gribble, Gordon W., ed. Metalation of Azoles and Related Five-Membered Ring Heterocycles. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31791-0.

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2

Boyer, Joseph H. Nitroazoles: The C-nitro derivatives of five-membered N- and N,O- heterocycles. VCH Publishers, 1986.

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3

Gupta, Radha R., Vandana Gupta, and Mahendra Kumar. Heterocyclic Chemistry : Volume II: Five-Membered Heterocycles. Springer London, Limited, 2013.

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Heterocyclic Chemistry : Volume II: Five-Membered Heterocycles. Springer, 2010.

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Gupta, Radha R., Vandana Gupta, and Mahendra Kumar. Heterocyclic Chemistry II: Five-Membered Heterocycles (Heterocyclic Chemistry). Springer, 1999.

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6

Organometallic Chemistry of Five-Membered Heterocycles. Elsevier, 2020. http://dx.doi.org/10.1016/c2017-0-02049-9.

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7

Sadimenko, Alexander. Organometallic Chemistry of Five-Membered Heterocycles. Elsevier, 2019.

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8

Sadimenko, Alexander. Organometallic Chemistry of Five-Membered Heterocycles. Elsevier, 2019.

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9

al, et, I. D. Sadekov, I. O. Sadekov, and D. S. Tarbell. Five Membered Tellurium-Containing Heterocycles (Sulfur Reports Series). Routledge, 1986.

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10

Hosseini, Hajar. Synthesis of New Five- and Six-Membered Heterocycles. Nova Science Publishers, Incorporated, 2019.

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Book chapters on the topic "Five-membered heterocycles"

1

Huang, Hanmin, and Pan Xie. "Five-Membered Heterocycles." In Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119006220.ch2.

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2

Wong, Henry N. C., Xue-Long Hou, Kap-Sun Yeung, and Hui Huang. "Five-Membered Heterocycles: Furan." In Modern Heterocyclic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527637737.ch6.

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3

Kaur, Navjeet. "Five-Membered N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-1.

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Kaur, Navjeet. "Five-Membered N-Heterocycles." In Metals and Non-Metals. CRC Press, 2020. http://dx.doi.org/10.1201/9780429321580-1.

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Revuelta, Julia, Fabrizio Machetti, and Stefano Cicchi. "Five-Membered Heterocycles: 1,3-Azoles." In Modern Heterocyclic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527637737.ch10.

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Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Five-Membered Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_3.

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Kaur, Navjeet. "Five-Membered Fused N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-3.

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Kaur, Navjeet. "Five-Membered N,N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-4.

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9

Kaur, Navjeet. "Five-Membered O,N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-6.

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Kaur, Navjeet. "Five-Membered Fused N-Heterocycles." In Metals and Non-Metals. CRC Press, 2020. http://dx.doi.org/10.1201/9780429321580-3.

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Conference papers on the topic "Five-membered heterocycles"

1

Fabian, Walter, Romina Brasca, Maria Kneeteman, and Pedro Mancini. "REACTIVITY, STEREO- AND REGIOSELECTIVITY OF DIELS-ALDER REACTIONS BETWEEN FIVE-MEMBERED HETEROCYCLES AND DANISHEFSKY'S DIENE." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-e002.

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Mancini, Pedro, Romina Brasca, Claudia Rosa, and María Kneeteman. "Theoretical Studies of five-membered aromatic Heterocycles in Cycloaddition Reactions as a Complement of the Experimental Researches." In The 10th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01454.

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Lazić, Anita, Ivana Đorđević, Kristina Gak Simić та ін. "Correlation of structure and potential pharmacological activity of spirohidantoins derived from α-Tetralone". У 37th International Congress on Process Industry. SMEITS, 2024. http://dx.doi.org/10.24094/ptk.024.279.

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Hydantoin is a nonaromatic five-membered heterocycle, which is considered a valuable, privileged scaffold in medicinal chemistry. The importance of the hydantoin scaffold in drug dis-covery has been reinforced by several medicines in clinical use, such as anticonvulsants (phenyto-in), antibiotics (nitrofurantoin), anticancer drugs (enzalutamide) and keratolytics (allantoin). To design new potentially pharmacologically active compounds, six spirohydantoin derivatives were synthetized and fully characterized by determination of the melting points, elemental analysis, FT-IR, 1H and 13C NMR spectr

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Bigović, Miljan, Marija Kaluđerović, Jovana Jovanović, Haris Majstorović, and Milica Kosović-Perutović. "Synthesis of Schiff bases between some five-membered heterocyclic aldehydes and thiocarbohydrazide (TCH) and optimization of reaction conditions." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.435b.

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The usual way of synthesizing imines (Schiff bases) between carbonyl compounds –aldehydes and ketones – with thiocarbohydrazide (TCH) involves heating them for 3 hours in a mixture of water solvents and ethanol with the addition of a catalytic amount of concentrated hydrochloric acid. Heating in the presence of acid catalysts over a long period of time may be unsuitable for acid-sensitive, labile, reactive or thermally unstable aldehydes, which are prone to polymerization under these conditions. We tested the condensation reaction at room temperature with a series of aldehydes, while maintaini

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Mereu, Federico, Jayangi D. Wagaarachchige, Zulkifli Idris, Klaus-Joachim Jens, and Maths Halstensen. "Response Surface Modelling to Reduce CO2 Capture Solvent Cost by Conversion of OZD to MEA." In 64th International Conference of Scandinavian Simulation Society, SIMS 2023 Västerås, Sweden, September 25-28, 2023. Linköping University Electronic Press, 2023. http://dx.doi.org/10.3384/ecp200003.

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The increasing CO2 concentration in the atmosphere is the most urgent global challenge. The most mature CO2 abatement option is post-combustion CO2 capture employing Monoethanolamine (MEA) solvent. One challenge of using MEA is its in-service degradation to 2-oxazolidinone (OZD), a heterocyclic five-membered organic ring compound. Furthermore, OZD degrades more MEA leading to CO2 capture solvent loss and hence increased operational cost. It is therefore of interest to investigate methods to convert OZD back to MEA. This work reports the conversion of 2-oxazolidinone to MEA by heat treatment at

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