Log in

Relevant bibliographies by topics / FL type 1 / Journal articles

To see the other types of publications on this topic, follow the link: FL type 1.

Journal articles on the topic 'FL type 1'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'FL type 1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Hayder, Yousif Abed, Thiab Humod Abdulrahim, and J. Humaidi Amjad. "Type 1 versus type 2 fuzzy logic speed controllers for brushless DC motors." International Journal of Electrical and Computer Engineering (IJECE) 10, no. 1 (2020): 265–74. https://doi.org/10.11591/ijece.v10i1.pp265-274.

Full text

Abstract:

This work presented two fuzzy logic (FL) schemes for speed-controlled brushless DC motors. The first controller is a Type 1 FL controller (T1FLC), whereas the second controller is an interval Type 2 FL controller (IT2FLC). The two proposed controllers were compared in terms of system dynamics and performance. For a fair comparison, the same type and number of membership functions were used for both controllers. The effectiveness of the structures of the two FL controllers was verified through simulation in MATLAB/SIMULINK environment. Simulation result showed that IT2FLC exhibited better perfo

APA, Harvard, Vancouver, ISO, and other styles

2

Abed, Hayder Yousif, Abdulrahim Thiab Humod, and Amjad J. Humaidi. "Type 1 versus type 2 fuzzy logic speed controllers for brushless dc motors." International Journal of Electrical and Computer Engineering (IJECE) 10, no. 1 (2020): 265. http://dx.doi.org/10.11591/ijece.v10i1.pp265-274.

Full text

Abstract:

<span lang="EN-US">This work presented two fuzzy logic (FL) schemes for speed-controlled brushless DC motors. The first controller is a Type 1 FL controller (T1FLC), whereas the second controller is an interval Type 2 FL controller (IT2FLC). The two proposed controllers were compared in terms of system dynamics and performance. For a fair comparison, the same type and number of membership functions were used for both controllers. The effectiveness of the structures of the two FL controllers was verified through simulation in MATLAB/SIMULINK environment. Simulation result showed that IT2F

APA, Harvard, Vancouver, ISO, and other styles

3

Singh, Satya P., Brian Tomkowicz, Derhsing Lai, et al. "Functional Role of Residues Corresponding to Helical Domain II (Amino Acids 35 to 46) of Human Immunodeficiency Virus Type 1 Vpr." Journal of Virology 74, no. 22 (2000): 10650–57. http://dx.doi.org/10.1128/jvi.74.22.10650-10657.2000.

Full text

Abstract:

ABSTRACT Vpr, encoded by the human immunodeficiency virus type 1 genome, contains 96 amino acids and is a multifunctional protein with features which include cell cycle arrest at G2, nuclear localization, participation in transport of the preintegration complex, cation channel activity, oligomerization, and interaction with cellular proteins, in addition to its incorporation into the virus particles. Recently, structural studies based on nuclear magnetic resonance and circular dichroism spectroscopy showed that Vpr contains a helix (HI)-turn-helix (HII) core at the amino terminus and an amphip

APA, Harvard, Vancouver, ISO, and other styles

4

Malyuzhinskaya, N. V., K. V. Stepanenko, and E. I. Volchansky. "Assessment of the functional state of the microvasculature in children with diabetes mellitus type 1." Medical Herald of the South of Russia 11, no. 2 (2020): 71–80. http://dx.doi.org/10.21886/2219-8075-2020-11-2-71-80.

Full text

Abstract:

Objective: to assess the functional state of the microvasculature in children with diabetes mellitus type 1 (DM type 1).Materials and methods: 63 children with a verifi ed diagnosis of diabetes mellitus type 1 were examined. Th e control group consisted of 30 practically healthy children. Methods: clinical, paraclinical (determination of glycated hemoglobin level, study of microcirculation indicators using laser Doppler fl owmetry (LDF), statistical.Results: microcirculatory disorders accompanying the course of diabetes mellitus type 1 depending on the length of illness were identifi ed. In ch

APA, Harvard, Vancouver, ISO, and other styles

5

Gurram, Rama Krishna, and Jinfang (Jeff) Zhu. "Functions of GATA-3 Expression in Regulatory T Cells During Type 1 and Type 2 Inflammation." Journal of Immunology 200, no. 1_Supplement (2018): 47.21. http://dx.doi.org/10.4049/jimmunol.200.supp.47.21.

Full text

Abstract:

Abstract The transcription factor GATA-3 is not only responsible for effector CD4 T cell differentiation, but also essential for the homeostasis and stability of regulatory T cells (Tregs). Previous study from our group has shown that mice with both T-bet and GATA-3 deletion in Tregs developed severe autoimmune disease correlated with Tregs switching from Tregs to Th17-like cells. However, mice with only GATA3 deletion in Tregs were normal at steady state. To determine the role of GATA-3 in Tregs during inflammation, we used Th1 and Th2 mouse models. Our results suggest that GATA-3-deficient T

APA, Harvard, Vancouver, ISO, and other styles

6

INOUE, KAORI, and TAKESHI KANETO. "A JONES TYPE INVARIANT OF LINKS IN THE PRODUCT SPACE OF A SURFACE AND THE REAL LINE." Journal of Knot Theory and Its Ramifications 03, no. 02 (1994): 153–61. http://dx.doi.org/10.1142/s0218216594000113.

Full text

Abstract:

We define invariants < L)−1 and FL(A) for links L in Σ × R where Σ is a surface by using the idea of Kauffman bracket. We compute < L)−1 in case of Σ = P2, a projective plane. In case of Σ = T2, a torus, we show examples of computations of FL(A) for a certain class of links L in T2 × R related to genus 1 Heegaard diagrams of lens spaces and a relation among them. This relation implies that FL(A) is a topological invariant for lens spaces in a certain sense.

APA, Harvard, Vancouver, ISO, and other styles

7

Beier, Ulf, Zhonglin Wang, Haiyan Xiao, Tricia Bhatti, Wayne Hancock, and Matthew Levine. "Targeting sirtuin-1 improves murine renal allograft survival and function (TRAN3P.901)." Journal of Immunology 192, no. 1_Supplement (2014): 202.40. http://dx.doi.org/10.4049/jimmunol.192.supp.202.40.

Full text

Abstract:

Abstract Pharmacologic inhibition of sirtuin-1 (Sirt1) augments suppressive functions of Foxp3+ regulatory T cells (Treg) and prolongs murine cardiac allograft survival. We investigated if Sirt1 targeting produced longer allograft function and allograft-dependent survival in a MHC-mismatched renal transplant model. After transplantation of BALB/c kindey allografts into C57Bl/6 wild type or fl-Sirt1/CD4cre recipients, native kidneys were removed three days post-operatively. We followed the mice for survival, and allograft function by weekly serum electrolyte and renal function (BUN, creatinine)

APA, Harvard, Vancouver, ISO, and other styles

8

Hamzeh, A., Sadeq A. Hamed, and Zakaria Al-Omari. "Wind Generation Impact on Symmetrical Fault Level at Grid Buses." International Journal of Electrical and Computer Engineering (IJECE) 8, no. 5 (2018): 2682. http://dx.doi.org/10.11591/ijece.v8i5.pp2682-2690.

Full text

Abstract:

This paper mainly aims at evaluating quantitatively the impact of wind turbine generators (WTGs) on fault level (FL) in case of a balanced fault occurring in the host grid (HG). This impact is not generic but it depends on the grid configuration, operation mode, and load profile; the impact may be positive for a network while it is negative for another one. Therefore, the impact will be estimated for a specific distribution network (DN). The grid faults and wind generations (WGs) are simulated by the simulation tool Power Factory DigSilent 14.0.506. The paper addresses the influence on FL of g

APA, Harvard, Vancouver, ISO, and other styles

9

A., Hamzeh, A. Hamed Sadeq, and Al-Omari Zakaria. "Wind Generation Impact on Symmetrical Fault Level at Grid Buses." International Journal of Electrical and Computer Engineering (IJECE) 8, no. 5 (2018): 2682–90. https://doi.org/10.11591/ijece.v8i5.pp2682-2690.

Full text

Abstract:

This paper mainly aims at evaluating quantitatively the impact of wind turbine generators (WTGs) on fault level (FL) in case of a balanced fault occurring in the host grid (HG). This impact is not generic but it depends on the grid configuration, operation mode, and load profile; the impact may be positive for a network while it is negative for another one. Therefore, the impact will be estimated for a specific distribution network (DN). The grid faults and wind generations (WGs) are simulated by the simulation tool Power Factory Dig Silent 14.0.506. The paper addresses the influence on FL of

APA, Harvard, Vancouver, ISO, and other styles

10

Kawabata, Kohei, Miya Kohashi, Shiori Akimoto, and Hiroyuki Nishi. "Structure Determination of Felodipine Photoproducts in UV-Irradiated Medicines Using ESI-LC/MS/MS." Pharmaceutics 15, no. 2 (2023): 697. http://dx.doi.org/10.3390/pharmaceutics15020697.

Full text

Abstract:

Dihydropyridine drugs are well known as photodegradable pharmaceuticals. Herein, we evaluate the photostability of felodipine (FL) medicine (Splendil® (SPL) tablets) and its altered forms (powders and suspensions). FL is a type of dihydropyridine drug, but its photochemical behavior is unknown. FL contents after ultraviolet light (UV) irradiation for 24 h were monitored using high-performance liquid chromatography (HPLC). Values of the residual amounts of FL in UV-irradiated SPL powders and suspensions were 32.76 ± 4.88% and 0.79 ± 0.74%, respectively, with the generation of two photoproducts

APA, Harvard, Vancouver, ISO, and other styles

11

Miles, Rodney R., Zhaosheng Lin, Megan S. Lim, and Kojo S. J. Elenitoba-Johnson. "Deregulation of the Insulin-Like Growth Factor Type 1 Receptor (IGF-1R) in Transformed Follicular Lymphomas: Implications for Novel Therapy." Blood 108, no. 11 (2006): 2407. http://dx.doi.org/10.1182/blood.v108.11.2407.2407.

Full text

Abstract:

Abstract Follicular lymphoma (FL) is the most common form of low-grade non-Hodgkin lymphoma in the western hemisphere. The vast majority of cases are incurable and transformation to diffuse large B-cell lymphoma (DLBCL) is an important cause of death. The molecular and biologic mechanisms underlying FL transformation are largely uncharacterized. In this study, we utilized a global quantitative proteomics approach for the identification of differentially expressed proteins associated with follicular lymphoma transformation. Five matched pairs of clonally identical cases of follicular lymphoma a

APA, Harvard, Vancouver, ISO, and other styles

12

Steinbicker, Andrea U., Claire Mayeur, Lisa K. Lohmeyer, et al. "Alk3, a BMP Type I Receptor Is Required for the Induction of Hepatic Hepcidin Gene Expression by Interleukin-6." Blood 118, no. 21 (2011): 686. http://dx.doi.org/10.1182/blood.v118.21.686.686.

Full text

Abstract:

Abstract Abstract 686 Introduction: Anemia of chronic disease (ACD), the second most prevalent form of anemia, is commonly associated with chronic inflammatory, infectious, or neoplastic conditions. ACD is characterized by high hepcidin levels that decrease serum iron levels by inducing degradation of the iron exporter ferroportin. In contrast, a relative deficiency of hepcidin leads to ferroportin overexpression and iron overload. Hepcidin is transcriptionally regulated by interleukin-6 (IL-6) and bone morphogenic protein (BMP) signaling. Binding of BMP ligands to type II and type I BMP recep

APA, Harvard, Vancouver, ISO, and other styles

13

Lelono, T. D., G. Bintoro, D. Setyohadi, and W. K. Sari. "Biologycal aspect of Indian Scad (Decapterus russelli) (Ruppell,1830) caugth in Bali and Madura Straits, and Southern waters of East Java, Indonesia." IOP Conference Series: Earth and Environmental Science 919, no. 1 (2021): 012005. http://dx.doi.org/10.1088/1755-1315/919/1/012005.

Full text

Abstract:

Abstract The way to determine whether the Indian scad (D. russelli) comes from the same stock or not, is using estimation morphology and biology. The kinship of D. russelli in the three waters is not too close, and it has a very distant kinship with D. macarellus and D. kurroides. D. russelli and D. macrosoma in Bali Strait and South Java is close. The results of the analysis show that two of five components of the characteristic morphometric factor of D. russelli in the three waters have a character differential percentage of 37.73% and similarity of 62.27%. The growth rate obtained (L∞) from

APA, Harvard, Vancouver, ISO, and other styles

14

Charnukha, Т. N., S. А. Likhachev, Е. А. Belahalovaya, E. К. Sidorovich та V. V. Vashсhylin. "Аutoimmune encephalitis associated with anti-LGI-1 antibodies". Russian neurological journal 28, № 4 (2023): 54–59. http://dx.doi.org/10.30629/2658-7947-2023-28-4-54-59.

Full text

Abstract:

Autoimmune encephalitis associated with anti-LGI-1 antibodies is a new type of autoimmune neurological disease.We present a description of a clinical case — this disease in a patient who was hospitalized at the Republican Scienti fi c and Practical Center for Neurology and Neurosurgery. During the analysis of blood and cerebrospinal fl uid for the presence of antibodies to autoimmune encephalitis, antibodies — IgG to anti-LGI-1 in the blood and cerebrospinal fl uid were detected. Conducted immune therapy, including intravenous administration of glucocorticosteroids, plasmapheresis and intraven

APA, Harvard, Vancouver, ISO, and other styles

15

Valiev, T. T., A. S. Volkova, M. A. Postoykina, et al. "Follicular lymphoma in children and adolescents: clinical, diagnostic and therapeutic features." Oncohematology 18, no. 3 (2023): 18–25. http://dx.doi.org/10.17650/1818-8346-2023-18-3-18-25.

Full text

Abstract:

Ffollicular lymphoma (FL) is one of the most common non-Hodgkin’s lymphomas in adults, while it is a diagnosis of exclusion in adolescents and children. Clinical manifestations of FL in children are represented by long-term asymptomatic lymphadenopathy, less commonly by extranodal areas involvement. treatment standards for FL in children have not been developed and may vary from observational tactics (with the radical resection of a single focus during a biopsy) to the use of radiation therapy and polychemotherapy. Pediatric type follicular lymphoma was first identified as a distinct variant i

APA, Harvard, Vancouver, ISO, and other styles

16

Jelloul, Fatima Zahra, Qiang Hua Chen, Tianyu Yang, et al. "Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases." International Journal of Surgical Pathology 26, no. 2 (2017): 135–44. http://dx.doi.org/10.1177/1066896917737161.

Full text

Abstract:

Background: Composite small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and follicular lymphoma (FL) is extremely rare, and only 13 cases have been reported previously. Methods: We identified 6 cases of composite SLL/CLL and FL in our database and studied their clinical, histologic, immunophenotypic, and cytogenetic features. A literature review of the existing cases was also conducted. Results: The patients included 4 males and 2 females, with a median age of 72 years. Four patients presented with lymphadenopathy and 2 with extranodal diseases. Lymphocytosis was seen in 2 case

APA, Harvard, Vancouver, ISO, and other styles

17

Arai, Hiroyuki, Eisuke Inoue, Kensei Yamaguchi, et al. "Clinical implication of using up both fluoropyrimidine (FU) and paclitaxel (PTX) in patients with severe peritoneal metastases (SPM) of gastric cancer (GC)." Journal of Clinical Oncology 39, no. 3_suppl (2021): 221. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.221.

Full text

Abstract:

221 Background: JCOG1108/WJOG7312G trial showed favorable but not significantly better outcomes of 5-FU/ l-leucovorin ( l-LV) /PTX combination (FLTAX) compared to 5-FU/ l-LV (FL) in untreated patients with SPM of GC. However, a half of patients treated with FL could not sequentially use PTX which is a key drug for peritoneal metastasis. We conducted a post hoc analysis to investigate the clinical implication of using up both FU and PTX in either combination or sequential strategy for GC patients with SPM. Methods: Among 101 patients enrolled in the trial (FL: N = 51; FLTAX: N = 50), overall su

APA, Harvard, Vancouver, ISO, and other styles

18

Akimova, Tatiana, Haiyan Xiao, Jing Jiao, et al. "Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells (MUC2P.818)." Journal of Immunology 192, no. 1_Supplement (2014): 68.2. http://dx.doi.org/10.4049/jimmunol.192.supp.68.2.

Full text

Abstract:

Abstract Induced Foxp3+ T-regulatory cells (iTreg) are essential to gastrointestinal immune homeostasis and play an important role in preventing autoimmune colitis. We have previously shown that inhibiting sirtuin-1 (Sirt1) can augment Treg function and hypothesized that targeting of Sirt1 might enhance iTreg development and thereby represent a potential therapy for inflammatory bowel disease (IBD). We adoptively transferred CD4+CD25-Foxp3- T effector (TE) cells from wild-type (C57BL/6) or fl-Sirt1/CD4cre mice into B6/Rag1-/- mice and monitored the mice until they lost 10-15% of their weight.

APA, Harvard, Vancouver, ISO, and other styles

19

Chen, Dong, Rajiv Pruthi, William L. Nichols, and John A. Heit. "Limitations of Current Plasma VonWillebrand Factor (VWF) Activity Tests: A Comprehensive Comparison of Five VWF Activity Assays." Blood 112, no. 11 (2008): 3376. http://dx.doi.org/10.1182/blood.v112.11.3376.3376.

Full text

Abstract:

Abstract Accurate measurement of plasma von Willebrand factor (VWF) activity is essential for the laboratory diagnosis and treatment monitoring of von Willebrand disease (VWD). Currently available VWF activity assays include VWF ristocetin cofactor activity by manual light transmission platelet aggregometry (VWF:RCo–Agg) or flow cytometry (VWF:RCo–FL), collagen I and III binding activity (VWF:Co–I and –III) (Technozym), and platelet activity by latex agglutination (VWF:Lx) (Instrumental Laboratory). In this study we evaluated and compared the accuracy and precision of these 5 assay methods. Pl

APA, Harvard, Vancouver, ISO, and other styles

20

DEMAREVA, V. A., JU A. EDELEVA, and A. A. MESHCHERYAKOVA. "“GLOBAL” EYE MOVEMENT MEASURES AS CORRELATES OF L2 PROFICIENCY." Vestnik Tomskogo gosudarstvennogo universiteta, no. 502 (2024): 5–12. https://doi.org/10.17223/15617793/502/1.

Full text

Abstract:

The effective acquisition of reading and reading comprehension skills in the language of instruction is a crucial factor influencing the success of the learning process in foreign language (FL) environments. Some studies have demonstrated that reading comprehension skills largely explain differences in the degree of learners’ mastery of a foreign language. A C-test can be employed to study the language competence of future students. Unlike standardized tests, C-test results provide more comprehensive information about students’ potential academic success. However, the cognitive mechanisms ensu

APA, Harvard, Vancouver, ISO, and other styles

21

Zhai, Lijie, April Bell, Evridiki Asimakidou, et al. "IMMU-27. NON-TUMOR CELL IDO1 NON-ENZYMATICALLY DECREASES RT + PD-1 MAB TREATMENT EFFICACY IN OLDER ADULTS WITH GLIOBLASTOMA." Neuro-Oncology 25, Supplement_5 (2023): v147—v148. http://dx.doi.org/10.1093/neuonc/noad179.0559.

Full text

Abstract:

Abstract Checkmate 498 is a large, randomized, phase 3 clinical trial that demonstrated an improved hazard ratio for younger but not older adults with MGMT unmethylated GBM treated with RT + PD-1 mAb. In an effort to better understand the biological determinant, indoleamine 2,3 dioxygenase 1 (IDO1), and its relationship with reducing RT + PD-1 mAb treatment efficacy in older adults with GBM, we created and/or compared 20-26 month-old C57BL/6 background mice that were IDO1-T2A-GFP [wild-type (WT); negative control (n=16)], IDO1 enzyme null [with normal IDO1 expression potential but incapable of

APA, Harvard, Vancouver, ISO, and other styles

22

Atacak, İsmail, Oğuzhan Çıtlak, and İbrahim Alper Doğru. "Application of interval type-2 fuzzy logic and type-1 fuzzy logic-based approaches to social networks for spam detection with combined feature capabilities." PeerJ Computer Science 9 (April 21, 2023): e1316. http://dx.doi.org/10.7717/peerj-cs.1316.

Full text

Abstract:

Background Social networks are large platforms that allow their users to interact with each other on the Internet. Today, the widespread use of social networks has made them vulnerable to malicious use through different methods such as fake accounts and spam. As a result, many social network users are exposed to the harmful effects of spam accounts created by malicious people. Although Twitter, one of the most popular social networking platforms, uses spam filters to protect its users from the harmful effects of spam, these filters are insufficient to detect spam accounts that exhibit new meth

APA, Harvard, Vancouver, ISO, and other styles

23

Rajack, F., L. Taddasse-Heath, and T. J. Naab. "Duodenal-Type Follicular Lymphoma: A Newly Recognized Entity in the 2016 World Health Organization Classification Update." American Journal of Clinical Pathology 154, Supplement_1 (2020): S61. http://dx.doi.org/10.1093/ajcp/aqaa161.131.

Full text

Abstract:

Abstract Introduction/Objective Most cases of primary follicular lymphoma (FL) in the gastrointestinal tract occur in the second part of the duodenum, presenting with multiple small polyps. Duodenal type follicular lymphoma (D-FL) is a newly recognized entity in the 2016 WHO classification update. Methods Upper endoscopy in a 72 year old female with iron deficiency anemia revealed a single 8 mm sessile polyp with no bleeding in the duodenal bulb. Histology revealed dense infiltrate of small mature lymphocytes with a nodular growth pattern. Follicles, composed predominantly of centrocytes with

APA, Harvard, Vancouver, ISO, and other styles

24

Dohle, Daniel-Sebastian, Travis Laverne, Joseph Bavaria, et al. "Aortic remodelling after thoracic endovascular aortic repair in acute and chronic type B aortic dissections." European Journal of Cardio-Thoracic Surgery 58, no. 4 (2020): 730–37. http://dx.doi.org/10.1093/ejcts/ezaa118.

Full text

Abstract:

Abstract OBJECTIVES Type B aortic dissections are routinely treated with thoracic endovascular aortic repair (TEVAR). The timing for TEVAR remains controversial and might have an impact on the remodelling capacity of the aorta. This study analyses and compares aortic remodelling in acute (ABD) and chronic (CBD) type B aortic dissections after TEVAR. METHODS This retrospective study analysed the preoperative, postoperative and at least 1-year follow-up computed tomography of 53 TEVAR patients (36 ABD, 17 CBD) at a single institution between May 2005 and May 2016. The volumes of aortic lumen (AL

APA, Harvard, Vancouver, ISO, and other styles

25

CHERNYH, O. N., and A. V. BURLACHENKO. "Assessment of the kinematic structure of the flow behind the well of a buried type of downstream AIC culverts." Prirodoobustrojstvo, no. 1 (2022): 34–40. http://dx.doi.org/10.26897/1997-6011-2022-1-34-40.

Full text

Abstract:

The purpose of the investigation is to study the operating conditions of the downstream of the low-pressure conjugation and water passageway structures of the reclamation complex of the agro-industrial complex (AIC) in relation to the structural scheme of culvert sections operating in the conditions of the conjugation of the pools by the type of a submerged jet in the presence of a deep, relatively short stilling well. A brief description of the laboratory installation, the measuring equipment used to record turbulent fl ow characteristics and the methodology for performing model studies is gi

APA, Harvard, Vancouver, ISO, and other styles

26

Freckmann, Guido, Stephan Arndt, Albrecht Fießelmann, et al. "Randomized Cross-Over Study Comparing Two Infusion Sets for CSII in Daily Life." Journal of Diabetes Science and Technology 11, no. 2 (2016): 253–59. http://dx.doi.org/10.1177/1932296816667510.

Full text

Abstract:

Background: Continuous subcutaneous insulin infusion (CSII) therapy is a valuable option especially for people with type 1 diabetes. Although insulin infusion sets (IIS) are essential components of most insulin pump systems, only few studies have been conducted on their performance and safety. In this study 2 IIS with soft cannulas were compared. Methods: In an open-label, randomized, crossover, multicenter 8-week study 80 type 1 diabetic subjects on CSII (20-74 years, mean 46.5 ± 12.9 years, 58.8% male) were enrolled to evaluate the use of 2 IIS. The Accu-Chek® FlexLink Plus (FL Plus) and the

APA, Harvard, Vancouver, ISO, and other styles

27

Yokota, Shin-ichi, Noriko Yokosawa, Tamaki Okabayashi, et al. "Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway." Journal of Virology 78, no. 12 (2004): 6282–86. http://dx.doi.org/10.1128/jvi.78.12.6282-6286.2004.

Full text

Abstract:

ABSTRACT We showed previously that herpes simplex virus type 1 (HSV-1) suppresses the interferon (IFN) signaling pathway during the early infection stage in the human amnion cell line FL. HSV-1 inhibits the IFN-induced phosphorylation of Janus kinases (JAK) in infected FL cells. In the present study, we showed that the suppressor of cytokine signaling-3 (SOCS3), a host negative regulator of the JAK/STAT pathway, is rapidly induced in FL cells after HSV-1 infection. Maximal levels of SOCS3 protein were detected at around 1 to 2 h after infection. This is consistent with the occurrence of HSV-1-

APA, Harvard, Vancouver, ISO, and other styles

28

Yang, Yisheng, Sean P. Bush, Xianjie Wen, Wei Cao та Lawrence Chan. "Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function". Endocrinology 158, № 1 (2016): 9–20. http://dx.doi.org/10.1210/en.2016-1541.

Full text

Abstract:

Abstract Mutations of GLI-similar 3 (GLIS3) underlie a neonatal diabetes syndrome. Genome-wide association studies revealed that GLIS3 variants are associated with both common type 1 and type 2 diabetes. Global Glis3-deficient (Glis3−/−) mice die of severe diabetes shortly after birth. GLIS3 controls islet differentiation by transactivating neurogenin 3 (Ngn3). To unravel the function of Glis3 in adults, we generated inducible global Glis3-deficient mice (Glis3fl/fl/RosaCreERT2). Tamoxifen (TAM)-treated Glis3fl/fl/RosaCreERT2 mice developed severe diabetes, which was reproduced in TAM-treated

APA, Harvard, Vancouver, ISO, and other styles

29

Kostrzewa-Susłow, Edyta, Jadwiga Dmochowska-Gładysz, and Tomasz Janeczko. "Microbial Transformation of Selected Flavanones as a Method of Increasing the Antioxidant Properties." Zeitschrift für Naturforschung C 65, no. 1-2 (2010): 55–60. http://dx.doi.org/10.1515/znc-2010-1-210.

Full text

Abstract:

Antioxidant properties of substrates [fl avanone (1), 6-hydroxy- (2), 7-hydroxy- (3), 5,7,4’- trihydroxy- (5), and 7-methoxyfl avanone (4)] and products of their microbial transformations, comprising hydroxylation, O-methylation, stereospecifi c reduction, dehydrogenation, and C-ring cleavage of the benzo-γ-pyrone system, were determined. Measurements of the antiradical activity (expressed as IC50 value) of both the substrates and the products led to the determination of the impact of type and location of substituents in the tested fl avonoids on changes in their antioxidant activities.

APA, Harvard, Vancouver, ISO, and other styles

30

Santos, Daniel Garcia, Matthias Schranzhofer, José Artur Bogo Chies, and Prem Ponka. "Heme Oxygenase 1 Plays An Unexpected Role During Erythroid Differentiation." Blood 118, no. 21 (2011): 344. http://dx.doi.org/10.1182/blood.v118.21.344.344.

Full text

Abstract:

Abstract Abstract 344 Red blood cells (RBC) are produced at a rate of 2.3 × 106 cells per second by a dynamic and exquisitely regulated process known as erythropoiesis. During this development, RBC precursors synthesize the highest amounts of total organismal heme (75–80%), which is a complex of iron with protoporphyrin IX. Heme is essential for the function of all aerobic cells, but if left unbound to protein, it can promote free radical formation and peroxidation reactions leading to cell damage and tissue injury. Therefore, in order to prevent the accumulation of ‘free' heme, it is imperati

APA, Harvard, Vancouver, ISO, and other styles

31

Li, Yiwen, Hongli Li, Mei-Nai Wang, et al. "Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibody." Blood 104, no. 4 (2004): 1137–44. http://dx.doi.org/10.1182/blood-2003-07-2585.

Full text

Abstract:

AbstractFMS-like tyrosine kinase 3 (FLT3), a class III receptor tyrosine kinase, is expressed at high levels in the blasts of approximately 90% of patients with acute myelogenous leukemia (AML). Internal tandem duplications (ITDs) in the juxtamembrane domain and point mutations in the kinase domain of FLT3 are found in approximately 37% of AML patients and are associated with a poor prognosis. We report here the development and characterization of a fully human anti-FLT3 neutralizing antibody (IMC-EB10) isolated from a human Fab phage display library. IMCEB10 (immunoglobulin G1 [IgG1], κ) bind

APA, Harvard, Vancouver, ISO, and other styles

32

Ryabukhina, Yu E., P. A. Zeynalova, O. L. Timofeeva, et al. "Use of obinutuzumab in therapy of patients with newly diagnosed follicular lymphoma. Experience of the Oncohematology Division of the Clinical Hospital “Lapino”." MD-Onco 3, no. 1 (2023): 53–60. http://dx.doi.org/10.17650/2782-3202-2023-3-1-53-60.

Full text

Abstract:

Follicular lymphoma (FL) is the most common indolent form of lymphoma and characterized by recurrent course and heterogenous clinical signs. Selection of treatment program for patients with newly diagnosed or recurrent FL is based primarily on the size of the tumor. While use of rituximab-containing regimens led to increased progression-free survival, in some cases tumors are refractory to rituximab. Understanding of molecular mechanisms of FL pathogenesis and action of anti-CD20 monoclonal antibodies allowed to develop new drugs with several advantages compared to rituximab. According to the

APA, Harvard, Vancouver, ISO, and other styles

33

Monnier, Vincent M., David R. Sell, Xiaoyu Gao, Saul M. Genuth, John M. Lachin, and Ionut Bebu. "Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC." BMJ Open Diabetes Research & Care 10, no. 1 (2022): e002667. http://dx.doi.org/10.1136/bmjdrc-2021-002667.

Full text

Abstract:

IntroductionTo assess impact of glycemic control on plasma protein-bound advanced glycation end products (pAGEs) and their association with subsequent microvascular disease.Research design and methodsEleven pAGEs were measured by liquid chromatography-mass spectrometry in banked plasma from 466 participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study at three time points (TPs): DCCT year 4 (TP1) and year 8 (TP2) and EDIC year 5/6 (TP3). Correlation coefficients assessed cross-sectional associations, and Cox proporti

APA, Harvard, Vancouver, ISO, and other styles

34

Robinson, Lisa J., Jonathan Soboloff, Irina L. Tourkova, et al. "The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1." PLOS ONE 18, no. 5 (2023): e0264596. http://dx.doi.org/10.1371/journal.pone.0264596.

Full text

Abstract:

The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice. To determine whether Orai1 has a direct, cell-intrinsic role in osteoblast differentiation and function, we bred Orai1 flox/flox (Orai1fl/fl) mice with Runx2-cre mice to eliminate its expression in osteoprogenitor cells. Interestingly, Orai1 was expressed in a mosaic pattern in Orai1fl/fl-Runx2-cre bone. Specifically, antibody labeling for Orai1 in vertebral sections was uniform in wild type animals, but patchy regions in

APA, Harvard, Vancouver, ISO, and other styles

35

Cancelas, Jose A., Wendy L. M. Koevoet, Alexandra E. de Koning, Angelique E. M. Mayen, Elwin J. C. Rombouts, and Rob E. Ploemacher. "Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells." Blood 96, no. 2 (2000): 498–505. http://dx.doi.org/10.1182/blood.v96.2.498.

Full text

Abstract:

Abstract Gap junctions (GJs) provide for a unique system of intercellular communication (IC) allowing rapid transport of small molecules from cell to cell. GJs are formed by a large family of proteins named connexins (Cxs). Cx43 has been considered as the predominantly expressed Cx by hematopoietic-supporting stroma. To investigate the role of the Cx family in hemopoiesis, we analyzed the expression of 11 different Cx species in different stromal cell lines derived from murine bone marrow (BM) or fetal liver (FL). We found that up to 5 Cxs are expressed in FL stromal cells (Cx43, Cx45, Cx30.3,

APA, Harvard, Vancouver, ISO, and other styles

36

Cancelas, Jose A., Wendy L. M. Koevoet, Alexandra E. de Koning, Angelique E. M. Mayen, Elwin J. C. Rombouts, and Rob E. Ploemacher. "Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells." Blood 96, no. 2 (2000): 498–505. http://dx.doi.org/10.1182/blood.v96.2.498.014k44_498_505.

Full text

Abstract:

Gap junctions (GJs) provide for a unique system of intercellular communication (IC) allowing rapid transport of small molecules from cell to cell. GJs are formed by a large family of proteins named connexins (Cxs). Cx43 has been considered as the predominantly expressed Cx by hematopoietic-supporting stroma. To investigate the role of the Cx family in hemopoiesis, we analyzed the expression of 11 different Cx species in different stromal cell lines derived from murine bone marrow (BM) or fetal liver (FL). We found that up to 5 Cxs are expressed in FL stromal cells (Cx43, Cx45, Cx30.3, Cx31, an

APA, Harvard, Vancouver, ISO, and other styles

37

Bunting, Kevin D., Heath L. Bradley, Teresa S. Hawley, Richard Moriggl, Brian P. Sorrentino, and James N. Ihle. "Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5." Blood 99, no. 2 (2002): 479–87. http://dx.doi.org/10.1182/blood.v99.2.479.

Full text

Abstract:

Abstract Signal transducers and activators of transcription (STATs) are intracellular mediators of cytokine receptor signals. Because many early-acting growth factors have been implicated in STAT5 activation, this study sought to investigate whether STAT5 may be a transcriptional regulator of hematopoietic stem cell (HSC) long-term repopulating activity. To test this possibility, bone marrow (BM) and fetal liver (FL) cells from mice containing homozygous deletions of both STAT5a and STAT5b genes (STAT5ab−/−) were characterized for hematopoietic repopulating activities. BM and FL grafts were ca

APA, Harvard, Vancouver, ISO, and other styles

38

Jaffe, Elaine S., and Antonino Carbone. "Evolution in the Definition of Follicular Lymphoma and Diffuse Large B-Cell Lymphoma: A Model for the Future of Personalized Medicine." Hemato 3, no. 3 (2022): 466–74. http://dx.doi.org/10.3390/hemato3030032.

Full text

Abstract:

The definitions of follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are evolving in the era of personalized medicine. Early stages of the evolution of FL have been recognized. Two histological manifestations of early lesions are in situ follicular neoplasia and duodenal type FL. Additionally, FL frequently undergoes histological transformation, the most common form being DLBCL. High-grade B-cell lymphoma with double hit, with translocations involving BCL2 and MYC are important clinically. Rarer forms of transformation include classic Hodgkin lymphoma (CHL) and histiocytic sar

APA, Harvard, Vancouver, ISO, and other styles

39

Ma, Jianli, Yuwei Deng, Shu Zhao, et al. "Abstract 3317: Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months." Cancer Research 83, no. 7_Supplement (2023): 3317. http://dx.doi.org/10.1158/1538-7445.am2023-3317.

Full text

Abstract:

Abstract Objective Follicular lymphoma (FL) occurring progression within 24 months (POD24) after initial immunochemotherapy has poor prognosis. GLUT1 affects glycolysis within tumor microenvironment (TME) and promotes tumor progression. However, its specific mediated mechanism remains unclear in FL. Methods Baseline GLUT1 expression, infiltrations of M2 macrophage, and CD8+ T-cells were assessed by immunohistochemistry in FL with POD24 and long-term remission respectively. The spatial features of TME were assessed by MIBI-TOF and proteomics. Predictive immunophenotypes for POD24 occurrence was

APA, Harvard, Vancouver, ISO, and other styles

40

Vollstedt, Sabine, Marco Franchini, Hans P. Hefti, et al. "Flt3 Ligand–treated Neonatal Mice Have Increased Innate Immunity Against Intracellular Pathogens and Efficiently Control Virus Infections." Journal of Experimental Medicine 197, no. 5 (2003): 575–84. http://dx.doi.org/10.1084/jem.20021900.

Full text

Abstract:

Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendritic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL treatment of newborn mice induced a &gt;100-fold increase in the innate resistance against infection with herpes simplex virus type 1 and Listeria monocytogenes. This resistance required interferon (IFN)-α/β for viral and interleukin (IL)-12 for bacterial infections. Long-term survival after viral but not bacterial infection was increased ∼100-fold by FL treatment. After treatment, CD11c+/majo

APA, Harvard, Vancouver, ISO, and other styles

41

Hoang, Monica, Sabina Paglialunga, Eric Bombardier, A. Russell Tupling та Jamie W. Joseph. "The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet–Induced Diabetes". Endocrinology 160, № 12 (2019): 2825–36. http://dx.doi.org/10.1210/en.2018-00936.

Full text

Abstract:

Abstract The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor (HIF)-1β (ARNT/HIF1β) plays a key role in maintaining β-cell function and has been shown to be one of the most downregulated transcription factors in islets from patients with type 2 diabetes. We have shown a role for ARNT/HIF1β in glucose sensing and insulin secretion in vitro and no defects in in vivo glucose homeostasis. To gain a better understanding of the role of ARNT/HIF1β in the development of diabetes, we placed control (+/+/Cre) and β-cell–specific ARNT/HIF1β knockout (fl/

APA, Harvard, Vancouver, ISO, and other styles

42

Capron, Claude, Catherine Lacout, Yann Lecluse, et al. "Role of the Transcription Factor LYL-1 in the Adult and Fetal Hematopoietic Stem Cells." Blood 104, no. 11 (2004): 2775. http://dx.doi.org/10.1182/blood.v104.11.2775.2775.

Full text

Abstract:

Abstract The hematopoietic stem cells (HSC) have the ability to self-renew and to give rise to all blood lineages. These processes occur via a hierarchy of progenitors with progressively more limited differentiation and self-renewal potential and are orchestrated by specialized protein such as transcription factors. LYL-1 protein contains a basic helix-loop-helix DNA binding motif also found in several proteins involved in the control of cellular proliferation and differentiation such as SCL/TAL-1. As LYL-1 shares an 80% homology at the protein level with SCL/TAL-1, we wanted to determine the

APA, Harvard, Vancouver, ISO, and other styles

43

Chrisikos, Taylor T., Yifan Zhou, Nina Denne, Athena Brooks, and Stephanie S. Watowich. "STAT3 and IL-10 inhibit interferon signaling in type 1 conventional dendritic cells." Journal of Immunology 206, no. 1_Supplement (2021): 97.13. http://dx.doi.org/10.4049/jimmunol.206.supp.97.13.

Full text

Abstract:

Abstract Conventional dendritic cells (cDCs) are the primary antigen presenting cells of the immune system, and thus control adaptive immunity. Type 1 cDCs (cDC1s) are crucial for mounting protective T cell responses against tumors and viruses. Recently, we reported that interleukin (IL)-10 inhibits polyinosinic-polycytidylic acid (poly I:C; a toll-like receptor 3 agonist) induced maturation of cDC1s in a signal transducer and activator of transcription (STAT) 3-dependent manner. In addition, using a tumor vaccine approach, we demonstrated that STAT3-deficient (Stat3Δ/Δ) cDC1s are more capable

APA, Harvard, Vancouver, ISO, and other styles

44

Kim, Tae-Hoon, Suk-Won Song, Woon Heo, et al. "Temporal pattern of aortic remodelling after endovascular treatment for chronic DeBakey IIIb dissection." Interactive CardioVascular and Thoracic Surgery 31, no. 2 (2020): 232–38. http://dx.doi.org/10.1093/icvts/ivaa070.

Full text

Abstract:

Abstract OBJECTIVES Endovascular treatment has emerged as a safe procedure for treating chronic DeBakey IIIb dissection. The objective of this study was to investigate the mid-term outcome and temporal pattern of aortic remodelling after endovascular treatment for DeBakey IIIb dissection. METHODS From 2012 to 2017, 85 patients who underwent endovascular aortic repair for DeBakey IIIb dissection were enrolled. The temporal pattern of aortic remodelling in terms of false lumen (FL) thrombosis [level 1 (∼T7), level 2 (T7 ∼ coeliac axis) and level 3 (coeliac trunk ∼ aortic bifurcation)] and aortic

APA, Harvard, Vancouver, ISO, and other styles

45

Silvestre, O., G. Borzacchiello, D. Nava, et al. "Bovine Papillomavirus Type 1 DNA and E5 Oncoprotein Expression in Water Buffalo Fibropapillomas." Veterinary Pathology 46, no. 4 (2009): 636–41. http://dx.doi.org/10.1354/vp.08-vp-0222-p-fl.

Full text

Abstract:

Papillomas and fibropapillomas may occur in the skin and in different organs in animals. Ten different genotypes of bovine papillomavirus (BPV) have been identified. BPV-1 through BPV-10 are all strictly species-specific, but BPV-1/2 may also infect other species such as equids, inducing fibroblastic tumors. BPV-1 and BPV-2 are associated with fibropapillomas in cattle; these tumors are formed by excessive proliferation of virus-infected dermal fibroblasts and epidermal keratinocytes. Nine water buffalo (Bubalus bubalis) were examined for the presence of multiple cutaneous and perivulvar tumor

APA, Harvard, Vancouver, ISO, and other styles

46

Moechtar, Herman. "Evolusi pengendapan sedimen Kuarter di daerah utara Air Musi, Kota Palembang - Sumatera Selatan." Indonesian Journal on Geoscience 2, no. 1 (2007): 1–13. http://dx.doi.org/10.17014/ijog.2.1.1-13.

Full text

Abstract:

http://dx.doi.org/10.17014/ijog.vol2no1.20071In the studied area, the sedimentary Quaternary facies consists of fl uvial channel separated by fl oodbasin, swamp, and fl oodplain deposits. Changes in channel style from channel 1, 2, and to 3 are interpreted as the result of a change in the type of river discharge from low to high sinuosity channels. Vertical changes in the character of these fl uvial channels can be related to changes in humidity. The lateral and vertical succession of the fl oodbasin and swamp environments shows evidence of decreasing and increasing of these facies. They are t

APA, Harvard, Vancouver, ISO, and other styles

47

Nesterova, E. S., S. K. Kravchenko, A. M. Kovrigina, et al. "Follicular lymphoma: first - line selection criteria of treatment." Terapevticheskii arkhiv 91, no. 8 (2019): 75–83. http://dx.doi.org/10.26442/00403660.2019.08.000388.

Full text

Abstract:

Follicular lymphoma (FL) is a tumor that develops from the B cells of the germinal center; characterized by recurrent and remitting course of the disease, the transformation of a tumor into diffuse large B-cell lymphoma (DLBCL) is possible. In generalized lesions and progression of FL, the most commonly used courses are R-CHOP and R-B. The choice of therapy for different cytological types, clinical and laboratory parameters remains disputable. Aim. To analyze the clinical, laboratory, morphological parameters of patients with FL, who got R-B and R-CHOP therapy; determine the criteria for selec

APA, Harvard, Vancouver, ISO, and other styles

48

Brülke, Christine, Oliver Bauer, and Moritz M. Sokolowski. "The influence of an interfacial hBN layer on the fluorescence of an organic molecule." Beilstein Journal of Nanotechnology 11 (November 3, 2020): 1663–84. http://dx.doi.org/10.3762/bjnano.11.149.

Full text

Abstract:

We investigated the ability of a single layer of hexagonal boron nitride (hBN) to decouple the excited state of the organic molecule 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA) from the supporting Cu(111) surface by Raman and fluorescence (FL) spectroscopy. The Raman fingerprint-type spectrum of PTCDA served as a monitor for the presence of molecules on the surface. Several broad and weak FL lines between 18,150 and 18,450 cm−1 can be detected, already from the first monolayer onward. In contrast, FL from PTCDA on a bare Cu(111) surface is present only from the second PTCDA layer onw

APA, Harvard, Vancouver, ISO, and other styles

49

Chu, Fuliang, Wencai Ma, Tomohide Yamazaki, et al. "PD-1+ T Cell Subsets in Follicular Lymphoma Tumor Microenvironment and Their Implications for Prognosis and Therapy." Blood 118, no. 21 (2011): 2648. http://dx.doi.org/10.1182/blood.v118.21.2648.2648.

Full text

Abstract:

Abstract Abstract 2648 Background: Programmed death (PD)-1, a coinhibitory receptor expressed by effector T cells (Teffs) is highly expressed on intratumoral T cells (mean 61%, range 34–86% for CD4+ T cells and mean 44%, range 31–69% for CD8+ T cells) in follicular lymphoma (FL), a finding associated with impaired ability to recognize autologous tumor (Nattamai et al, ASH 2007). Hence, PD-1 expression would be expected to confer an unfavorable prognosis in FL. However, correlation of PD-1 with clinical outcome in FL has been inconsistent with two studies showing favorable (Carreras et al, J Cl

APA, Harvard, Vancouver, ISO, and other styles

50

Jacobsen, SE, OP Veiby, J. Myklebust, C. Okkenhaug, and SD Lyman. "Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha." Blood 87, no. 12 (1996): 5016–26. http://dx.doi.org/10.1182/blood.v87.12.5016.bloodjournal87125016.

Full text

Abstract:

The recently cloned flt3 ligand (FL) stimulates the growth of primitive hematopoietic progenitor cells through synergistic interactions with multiple other cytokines. The present study is the first demonstrating cytokines capable of inhibiting FL-stimulated hematopoietic cell growth. Tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta 1 (TGF-beta l) potently inhibited the clonal growth of murine Lin-Sca-l+ bone marrow progenitors stimulated by FL alone or in combination with granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF), interleukin (IL)-3, IL-6,

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!