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Journal articles on the topic 'Flavanone Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Poerwono, Hadi, and Marcellino Rudyanto. "Bibliometric Study of Microwave-Assisted Synthesis of Flavanone Derivatives." Borneo Journal of Pharmacy 6, no. 4 (2023): 339–48. http://dx.doi.org/10.33084/bjop.v6i4.5602.

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This study aims to describe various studies related to synthesizing flavanone derivatives using the microwave-assisted method with a bibliometric approach. Metadata information was collected from Scopus on June 30th, 2023, with three keywords (microwave-assisted OR microwave, synthesis, and flavanone) searched for article titles, abstracts, and keywords. Analysis and research mapping were carried out with VOSviewer. Of the 33 articles relevant for analysis, 15 keyword clusters were obtained, most of which contained a list of flavanone derivatives. Interestingly, none of these clusters contain

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2

Sinyeue, Cynthia, Mariko Matsui, Michael Oelgemöller, et al. "Synthesis and Investigation of Flavanone Derivatives as Potential New Anti-Inflammatory Agents." Molecules 27, no. 6 (2022): 1781. http://dx.doi.org/10.3390/molecules27061781.

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Flavonoids are polyphenols with broad known pharmacological properties. A series of 2,3-dihydroflavanone derivatives were thus synthesized and investigated for their anti-inflammatory activities. The target flavanones were prepared through cyclization of 2′-hydroxychalcone derivatives, the later obtained by Claisen–Schmidt condensation. Since nitric oxide (NO) represents an important inflammatory mediator, the effects of various flavanones on the NO production in the LPS-induced RAW 264.7 macrophage were assessed in vitro using the Griess test. The most active compounds were flavanone (4G), 2′

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3

Maciel Diogo, Gabriela, Josimara Souza Andrade, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Viviane Martins Rebello Dos Santos, and Jason Guy Taylor. "Trypanocidal Activity of Flavanone Derivatives." Molecules 25, no. 2 (2020): 397. http://dx.doi.org/10.3390/molecules25020397.

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Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step s

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4

Kłósek, Małgorzata, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow, et al. "In Vitro Anti-Inflammatory Activity of Methyl Derivatives of Flavanone." Molecules 28, no. 23 (2023): 7837. http://dx.doi.org/10.3390/molecules28237837.

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Inflammation plays an important role in the immune defense against injury and infection agents. However, the inflammatory chronic process may lead to neurodegenerative diseases, atherosclerosis, inflammatory bowel diseases, or cancer. Flavanones present in citrus fruits exhibit biological activities, including anti-oxidative and anti-inflammatory properties. The beneficial effects of flavanones have been found based on in vitro cell cultures and animal studies. A suitable in vitro model for studying the inflammatory process are macrophages (RAW264.7 cell line) because, after stimulation using

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5

Felgines, Catherine, Odile Texier, Christine Morand, et al. "Bioavailability of the flavanone naringenin and its glycosides in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 6 (2000): G1148—G1154. http://dx.doi.org/10.1152/ajpgi.2000.279.6.g1148.

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Naringenin, the predominant flavanone in grapefruit, mainly occurs as glycosides such as naringenin-7- rhamnoglucoside or naringenin-7-glucoside. This study compared kinetics of absorption of naringenin and its glycosides in rats either after a single flavanone-containing meal or after adaptation to a diet for 14 days. Regardless of the diet, circulating metabolites were glucurono- and sulfoconjugated derivatives of naringenin. The kinetics of absorption of naringenin and naringenin-7-glucoside were similar, whereas naringenin-7-rhamnoglucoside exhibited a delay in its intestinal absorption, r

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6

De, Surya K., Mrinal G. Dhara, and Asok K. Mallik. "Synthesis of trans-2,3-dimethoxy-3- (phenylamino)flavanones and related compounds." Canadian Journal of Chemistry 76, no. 2 (1998): 199–204. http://dx.doi.org/10.1139/v97-219.

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trans-2,3-Dimethoxy-3-(phenylamino)flavanones (2), a new type of flavanone derivatives, are synthesized from flavanones or 2'-hydroxychalcones in two steps, the first one being a condensation with nitrosobenzenes (Ehrlich-Sachs reaction) and the second an oxidation with (diacetoxyiodo)benzene in methanol. Nitrone formation, an important side reaction of the Ehrlich-Sachs reaction, has also been exploited to synthesize 2 simply by use of an excess of nitrosobenzene in aqueous methanol. Syntheses of several analogues of 2 are also reported.Key words: trans-2,3-dimethoxy-3-(phenylamino)flavanones

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7

Łodyga-Chruścińska, Elżbieta, Agnieszka Kowalska-Baron, Paulina Błazińska, et al. "Position Impact of Hydroxy Groups on Spectral, Acid–Base Profiles and DNA Interactions of Several Monohydroxy Flavanones." Molecules 24, no. 17 (2019): 3049. http://dx.doi.org/10.3390/molecules24173049.

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Structure-related biological activities of flavanones are still considered largely unexplored. Since they exhibit various medicinal activities, it is intriguing to enter deeper into their chemical structures, electronic transitions or interactions with some biomolecules in order to find properties that allow us to better understand their effects. Little information is available on biological activity of flavanone and its monohydroxy derivatives in relation to their physicochemical properties as spectral profiles, existence of protonated/deprotonated species under pH changes or interaction with

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8

Mottaghipisheh, Javad, and Marcello Iriti. "Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review." Molecules 25, no. 18 (2020): 4146. http://dx.doi.org/10.3390/molecules25184146.

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Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated fro

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9

Syah, Yana M., and Emilio L. Ghisalberti. "Flavanone derivatives from Macaranga tanarius." Biochemical Systematics and Ecology 62 (October 2015): 151–54. http://dx.doi.org/10.1016/j.bse.2015.08.009.

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10

Oganesyan, Eduard T., та Stanislav S. Shatokhin. "USING QUANTUM-CHEMICAL PARAMETERS FOR PREDICTING ANTI-RADICAL (НО∙) ACTIVITY OF RELATED STRUCTURES CONTAINING A CINNAMOYL FRAGMENT II. DERIVATIVES OF 2’,4’-DIHYDROXYCHALCONE, FLAVANONE AND FLAVONE, CONTAINING A HYDROXY GROUP IN POSITION 7". Pharmacy & Pharmacology 8, № 2 (2020): 112–23. http://dx.doi.org/10.19163/2307-9266-2020-8-2-112-123.

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42 derivatives of 2’,4’-dihydroxychalcone, flavanone and flavone, containing the hydroxy group in position 7 (ring "A"), as well as substituents in the ring "B", have been studied.The aim is to study the quantum-chemical parameters of 2',4'-dihydroxychalcone, flavanone and flavone derivatives containing a hydroxy group in position 7, in order to identify the effect of substituents on Mulliken charges (a.e) in the aromatic core "A", bond numbers (Nµ), the unsaturation index (IUA) and the electron density of the carbon atoms of the cinnamoyl fragment.Materials and methods. The listed above param

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11

Mardjan, Muhammad Idham Darussalam, Retno Ambarwati, Sabirin Matsjeh, Tutik Dwi Wahyuningsih, and Winarto Haryadi. "SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE." Indonesian Journal of Chemistry 12, no. 1 (2012): 70–76. http://dx.doi.org/10.22146/ijc.21374.

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Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave

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12

Bustos-Salgado, Paola, Berenice Andrade-Carrera, Valeri Domínguez-Villegas, et al. "In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments." Pharmaceutics 15, no. 6 (2023): 1632. http://dx.doi.org/10.3390/pharmaceutics15061632.

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The increasing number of skin cancer cases worldwide and the adverse side effects of current treatments have led to the search for new anticancer agents. In this present work, the anticancer potential of the natural flavanone 1, extracted from Eysenhardtia platycarpa, and four flavanone derivatives 1a–d obtained by different reactions from 1 was investigated by an in silico study and through cytotoxicity assays in melanoma (M21), cervical cancer (HeLa) cell lines and in a non-tumor cell line (HEK-293). The free compounds and compounds loaded in biopolymeric nanoparticles (PLGA NPs 1, 1a–d) wer

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13

Sykuła, Anna, Agnieszka Kowalska-Baron, Krystian Gałęcki, Paulina Błazińska, and Elżbieta Łodyga-Chruścińska. "Structural and Spectral Investigation of a Series of Flavanone Derivatives." Molecules 26, no. 5 (2021): 1298. http://dx.doi.org/10.3390/molecules26051298.

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Four flavanone Schiff bases (E)-1-(2-phenylchroman-4-ylidene)thiosemicarbazide (FTSC) (1), N′,2-bis((E)-2-phenylchroman-4-ylidene)hydrazine-1-carbothiohydrazide (FTCH) (2), (E)-N’-(2-phenylchroman-4-ylidene)benzohydrazide (FHSB) (3) and (E)-N′-(2-phenylchroman-4-ylidene)isonicotinohydrazide (FIN) (4) were synthesized and evaluated for their electronic and physicochemical properties using experimental and theoretical methods. One of them, (2), consists of two flavanone moieties and one substituent, the rest of the compounds (1, 3, 4) comprises of a flavanone-substituent system in relation to 1:

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14

Nobushi, Yasuhito, Taira Wada, Motofumi Miura, et al. "Effects of Flavanone Derivatives on Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells." Life 14, no. 11 (2024): 1446. http://dx.doi.org/10.3390/life14111446.

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Flavanones, a class of flavonoids, are abundant in fruits, vegetables, and herbs. They are known to have several biological activities, such as anti-inflammatory and anti-cancer activities, but their effects on obesity remain unclear. Obesity is closely associated with adipocyte differentiation and lipid accumulation in adipose tissue. Therefore, in this study, we examined the effects of flavanone derivatives on adipocyte differentiation and lipid accumulation by using 3T3-L1 cells. Among the 15 flavanone derivatives studied, 4′-phenylflavanone (4PF), with a biphenyl structure, significantly i

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15

Hikisz, Pawel, Piotr Wawrzyniak, Angelika A. Adamus-Grabicka, Damian Jacenik, and Elzbieta Budzisz. "Evaluation of In Vitro Biological Activity of Flavanone/Chromanone Derivatives: Molecular Analysis of Anticancer Mechanisms in Colorectal Cancer." International Journal of Molecular Sciences 25, no. 23 (2024): 12985. https://doi.org/10.3390/ijms252312985.

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The primary objective of this study was to evaluate the anticancer activity of six flavanone/chromanone derivatives: 3-benzylideneflavanones/3-benzylidenechroman-4-ones and their 3-spiro-1-pirazolines analogs. We employed five colon cancer cell lines with varying degrees of metastasis and genetic profiles as our research model. Our investigation focused primarily on assessing the pro-oxidant properties of the tested derivatives and their impact on overall antiproliferative activity. To comprehensively evaluate the cytotoxic properties of these compounds, we analyzed their genotoxic, pro-apopto

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16

Yang, Peng-Fei, Ya-Nan Yang, Chun-Yu He, et al. "New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities." Molecules 24, no. 5 (2019): 850. http://dx.doi.org/10.3390/molecules24050850.

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The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4–9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1–8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprote

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17

Bustos-Salgado, Paola, Berenice Andrade-Carrera, Valeri Domínguez-Villegas, et al. "Biopharmaceutic study and in vivo efficacy of natural and derivatives flavanones formulations." Nanomedicine 16, no. 3 (2021): 205–20. http://dx.doi.org/10.2217/nnm-2020-0368.

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Aim: The development and characterization of nanostructured flavanone formulations (FF) of 1 extracted from Eysenhardtia platycarpa and 1a, 1b, 1c and 1d derivatives by structural modification of 1 as anti-inflammatory candidates for topical treatment of local inflammation. Materials & methods: The FF were physicochemical characterized and the behavior release, skin permeation and, in vivo anti-inflammatory efficacy in the rat model were studied. Results: The FF revealed sustained drug release and showed slow drug penetration in human skin. The FF reduced inflammation in comparison with th

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18

Fareza, Muhamad S., Yana M. Syah, Didin Mujahidin, Lia D. Juliawaty, and Iis Kurniasih. "Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa." Zeitschrift für Naturforschung C 69, no. 9-10 (2014): 375–80. http://dx.doi.org/10.5560/znc.2014-0066.

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Abstract Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1 - 4), from the acetone extract of the leaves of Macaranga trichocarpa. Reexamination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and fou

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19

Bhatti, Huma, Rubina Rubina, Faisal Rashid, Sumera Zaib, Jamshed Iqbal, and Abdul Hameed. "Synthesis and antitumor activities of novel Mannich base derivatives derived from natural flavonoids." Natural Resources for Human Health 2, no. 2 (2022): 100–106. http://dx.doi.org/10.53365/nrfhh/141866.

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In our current study, a series of reactions with isolated natural flavonoids (2-phenylchromen-4-one) and flavanone (2,3-dihydro-2-phenylchromen-4-one) through Mannich base was carried out by a one-pot three-component reaction. Their structure-activity relationship study (SAR) reveals the anticancer activity of natural compounds and their Mannich bases. The flavones were substituted by imine at position C-8, while in the flavanones, the reaction takes place at positions C-8 and C-3. Spectroscopic techniques characterized all the isolated and newly synthesized derivatives. Anticancer activity wa

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20

Fu, X., T. Sévenet, F. Remy, M. Païs, A. Hamid A. Hadi, and L. M. Zeng. "Flavanone and Chalcone Derivatives from Cryptocarya kurzii." Journal of Natural Products 56, no. 7 (1993): 1153–63. http://dx.doi.org/10.1021/np50097a021.

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21

Shi, Lei, Xiu E. Feng, Jing Rong Cui, Lian Hua Fang, Guan Hua Du, and Qing Shan Li. "Synthesis and biological activity of flavanone derivatives." Bioorganic & Medicinal Chemistry Letters 20, no. 18 (2010): 5466–68. http://dx.doi.org/10.1016/j.bmcl.2010.07.090.

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22

Wang, Enhua, Lishou Yang, Qian Yang, et al. "Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells." RSC Advances 12, no. 43 (2022): 28098–103. http://dx.doi.org/10.1039/d2ra03562f.

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23

Adamus-Grabicka, Angelika A., Pawel Hikisz, Artur Stepniak, et al. "Molecular Pro-Apoptotic Activities of Flavanone Derivatives in Cyclodextrin Complexes: New Implications for Anticancer Therapy." International Journal of Molecular Sciences 25, no. 15 (2024): 8488. http://dx.doi.org/10.3390/ijms25158488.

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This study evaluates the antiproliferative potential of flavanones, chromanones and their spiro-1-pyrazoline derivatives as well as their inclusion complexes. The main goal was to determine the biological basis of molecular pro-apoptotic activities and the participation of reactive oxygen species (ROS) in shaping the cytotoxic properties of the tested conjugates. For this purpose, changes in mitochondrial potential and the necrotic/apoptotic cell fraction were analyzed. Testing with specific fluorescent probes found that ROS generation had a significant contribution to the biological anticance

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24

Mphahlele, Malose J. "ChemInform Abstract: Schmidt Reaction of Flavanone Derivatives: Synthesis of Benzoheterazepine Derivatives." ChemInform 42, no. 21 (2011): no. http://dx.doi.org/10.1002/chin.201121212.

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25

Wang, Nai-Xing, Yalan Xing, and Yan-Jing Wang. "Asymmetric Synthesis of Chiral Flavanone and Chromanone Derivatives." Current Organic Chemistry 17, no. 14 (2013): 1555–62. http://dx.doi.org/10.2174/1385272811317140010.

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26

Pawlak, Aleksandra, Marta Henklewska, Beatriz Hernández-Suárez та ін. "Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones—Comparison of Their Anti-Tumor Activity In Vitro". Molecules 26, № 20 (2021): 6295. http://dx.doi.org/10.3390/molecules26206295.

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Background: The study investigated four flavanone-derived γ-oxa-ε-lactones: a parent unsubstituted compound and its three derivatives with the methoxy group in positions 2′, 4′ and 8. Our objective was to find out if the introduction of the methoxy group into the aromatic ring affects in vitro anti-tumor potency of the investigated lactones. Methods: Cytotoxic and pro-apoptotic effects were assessed with cytometric tests with propidium iodide, annexin V, and Western blot techniques. We also investigated potential synergistic potency of the tested lactones and glucocorticoids in canine lymphoma

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27

Krawczyk-Łebek, Agnieszka, Monika Dymarska, Tomasz Janeczko, and Edyta Kostrzewa-Susłow. "4′-Methylflavanone Glycosides Obtained Using Biotransformation in the Entomopathogenic Filamentous Fungi Cultures as Potential Anticarcinogenic, Antimicrobial, and Hepatoprotective Agents." International Journal of Molecular Sciences 23, no. 10 (2022): 5373. http://dx.doi.org/10.3390/ijms23105373.

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Flavonoid compounds exhibit numerous biological activities and significantly impact human health. The presence of methyl or glucosyl moieties attached to the flavonoid core remarkably modifies their physicochemical properties and improves intestinal absorption. Combined chemical and biotechnological methods can be applied to obtain such derivatives. In the presented study, 4′-methylflavanone was synthesized and biotransformed in the cultures of three strains of entomopathogenic filamentous fungi, i.e., Isaria fumosorosea KCH J2, Beauveria bassiana KCH J1.5, and Isaria farinosa KCH J2.1. The mi

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28

Zheng, Xu Xu, Jing Jing Xie, Zhong Yi Yin, and Jia Jia Jing. "A Simple Method of Cyclization of the 2'-Hydroxychalcone with Polystyrene-Pyridine Resine under Mild Conditions." Advanced Materials Research 295-297 (July 2011): 1156–59. http://dx.doi.org/10.4028/www.scientific.net/amr.295-297.1156.

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The satisfying cyclization of 2’-hydroxy chalcone to flavanone using polystyrene-pyridine resine as catalyst and methanol as solvent under mild conditions is reported here. The method is appropriate for 2’-hydroxy chalcone derivatives with electron group in B-ring.

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29

Oganesyan, E. T., and S. S. Shatokhin. "USE OF QUANTUM-CHEMICAL PARAMETERS FOR FORECASTING ANTIRADICAL (HO·) ACTIVITY OF RELATED STRUCTURES CONTAINING A CINNAMIC MOLD FRAGMENT. III. CHALCONES, FLAVANONES AND FLAVONES WITH PHLOROGLUCINIC TYPE OF RING “A”." Pharmacy & Pharmacology 8, no. 6 (2021): 446–55. http://dx.doi.org/10.19163/2307-9266-2020-8-6-446-455.

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42 derivatives of chalcone, flavanone and flavone having a phloroglucinic type of ring “A” and containing the same electron-donating substituents on ring “B”, have been studied. Flavonoids with the phloroglucinic type of ring “A” are the most common in nature, which is due to the peculiarities of biogenetic formation with the participation of malonyl and acetyl fragments.The aim of the article is to determine the effect of the hydroxy group in position 6' of chalcones and in position 5 of flavanones and flavones on bond numbers (Nµ), free valence indices (Fµ), Mulliken charges (a.e), electron

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30

Passreiter, Claus M., Anke-Katrin Suckow-Schnitker, Andreas Kulawik, Jonathan Addae-Kyereme, Colin W. Wright, and Wim Wätjen. "Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death." Phytochemistry 117 (September 30, 2015): 237–44. https://doi.org/10.1016/j.phytochem.2015.04.002.

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Passreiter, Claus M., Suckow-Schnitker, Anke-Katrin, Kulawik, Andreas, Addae-Kyereme, Jonathan, Wright, Colin W., Wätjen, Wim (2015): Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death. Phytochemistry 117: 237-244, DOI: 10.1016/j.phytochem.2015.04.002, URL: http://dx.doi.org/10.1016/j.phytochem.2015.04.002

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Suryani, Novia, Sabirin Matsjeh, and Respati Tri Swasono. "Synthesis and Heme Polymerization Inhibitory Activity (HPIA) Assay of Chalcone, Flavone and Flavanone Derivatives." Materials Science Forum 948 (March 2019): 109–14. http://dx.doi.org/10.4028/www.scientific.net/msf.948.109.

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Chalcone, flavone, and flavanone had been synthesized as candidate of the antimalarial compounds. The chalcone 1was synthesised from 2,4-dihydroxyacetophenone and 4-metoxybenzaldehyde as starting materials using base catalyst KOH via Claisen-Schmidt Condensation. The synthesis flavone 2was carried out by cyclization of chalcone 1using I2 in DMSO, while the flavanone 3was produced by cyclization of chalcone 1using NaOAc as a base catalyst. An in vitro antimalarial activity of the compound 1, 2and 3have been evaluated with the chloroquine diphosphate as a positive control in various concentratio

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32

Sabrin, Mirza Synthia, Erdenechimeg Selenge, Yohei Takeda, et al. "Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus." Phytochemistry 191 (November 30, 2021): 1–9. https://doi.org/10.1016/j.phytochem.2021.112896.

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Sabrin, Mirza Synthia, Selenge, Erdenechimeg, Takeda, Yohei, Batkhuu, Javzan, Ogawa, Haruko, Jamsransuren, Dulamjav, Suganuma, Keisuke, Murata, Toshihiro (2021): Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus. Phytochemistry (112896) 191: 1-9, DOI: 10.1016/j.phytochem.2021.112896, URL: http://dx.doi.org/10.1016/j.phytochem.2021.112896

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Nagashima, Fumihiro, Yuki Tabuchi, Takuya Ito, Liva Harinantenaina, and Yoshinori Asakawa. "Terpenoids, Flavonoids and Acetogenins from Some Malagasy Plants." Natural Product Communications 11, no. 2 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100205.

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Humulanes, drimanes, ent-kaurane, lupane, cycloartane, flavanone, flavones and quinol derivatives were isolated from Malagasy Cussonia vantsilana, Helichrysum gymnocephalum, Phyllarthron madagascariense, Gomphocarpus fructicosus, Cinnamosma sp. and C. fragrans, and their structures elucidated by using extensive NMR analysis. A mixture of a few flavones and/or lupane triterpene showed antimicrobial activity against Mycobacterium smegmatis and Pseudomonas aeruginosa.

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Konieczny, Wojciech, and Marek Konieczny. "Synthesis of Thioflavanone and Flavanone Derivatives by Cyclization of Chalcones." Synthesis 2009, no. 11 (2009): 1811–14. http://dx.doi.org/10.1055/s-0029-1216791.

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35

Albogami, Abdullah S., Hamad Z. Alkhathlan, Tamer S. Saleh, and Ahmed M. Elazzazy. "Microwave-Assisted Synthesis of Potent Antimicrobial Agents of Flavanone Derivatives." Oriental Journal of Chemistry 30, no. 2 (2014): 435–43. http://dx.doi.org/10.13005/ojc/300205.

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36

Tóth, Gábor, András Simon, Albert Lévai, Hanspeter Kählig, and Hermann Kalchhauser. "17O NMR studies on (E)-3-arylidenechromanone and -flavanone derivatives." Magnetic Resonance in Chemistry 39, no. 8 (2001): 463–65. http://dx.doi.org/10.1002/mrc.877.

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37

Wang, Nai-Xing, Yalan Xing, and Yan-Jing Wang. "ChemInform Abstract: Asymmetric Synthesis of Chiral Flavanone and Chromanone Derivatives." ChemInform 44, no. 51 (2013): no. http://dx.doi.org/10.1002/chin.201351249.

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38

Song, Lijun, Jie Zheng, Li Zhang, et al. "Phytochemical Profiling and Fingerprint Analysis of Chinese Jujube (Ziziphus jujuba Mill.) Leaves of 66 Cultivars from Xinjiang Province." Molecules 24, no. 24 (2019): 4528. http://dx.doi.org/10.3390/molecules24244528.

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Foliage of jujube (Ziziphus jujuba Mill.) as a byproduct of agriculture, is a traditional nutraceutical material in China. Previous studies have shown that it is a rich resource of polyphenols. However, information on its complete phenolic profile and the difference between cultivars is still limited. This study investigated and compared phytochemical profiles of leaves of 66 Chinese jujube cultivars. Forty-two compounds, including 22 flavonols, two flavanols, one flavanone, 13 derivatives of phenolic acids, three simple acids, and one unknown hexoside were identified/tentatively identified us

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39

Orhan, Didem Deliorman, Esra Küpeli, Erdem Yesilada, and Fatma Ergun. "Anti-Inflammatory and Antinociceptive Activity of Flavonoids Isolated from Viscum album ssp. album." Zeitschrift für Naturforschung C 61, no. 1-2 (2006): 26–30. http://dx.doi.org/10.1515/znc-2006-1-205.

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Abstract Viscum album L. has been used in the indigenous systems of medicine for treatment of headache and some inflammatory diseases. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the five flavonoids (5,7-dimethoxy naringenin or 4′,6′- dimethoxy chalcononaringenin) derivatives, isolated from the ethyl acetate fraction of the extract from V. album ssp. album, were investigated, namely 5,7-dimethoxy-flavanone-4′-O- β-ᴅ-glucopyranoside (1), 2′-hydroxy-4′,6′-dimethoxy-chalcone-4-O-β-ᴅ-glucopyranoside (2), 5,7-dimethoxy-flavanone-4′-O-[2″-O-(5‴-O-trans-

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40

Dalla Costa, Vanessa, Anna Piovan, Ina Varfaj, Maria Carla Marcotullio, Paola Brun, and Raffaella Filippini. "From “Maraschino” to Cell Cultures: A Deep Study on Prunus cerasus L. Cell Culture Juices." Molecules 30, no. 5 (2025): 1089. https://doi.org/10.3390/molecules30051089.

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Prunus cerasus var. Marasca (Rosaceae) is an important Croatian cultivar, known wordwide for the production of Luxardo maraschino liqueur, which occurs in the eastern Po Valley of Italy. Besides liqueur, Marasca is attractive for its beneficial effects on human health and well-being. The undifferentiated in vitro cell cultures of Marasca were investigated as a source of healthy products. The in vitro conditions for obtaining callus and suspension cultures under photoperiod were defined. The cell lines were evaluated for growth rate, total phenol and proanthocyanidin contents, and antioxidant a

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41

Wattanapiromsakul, Chatchai, and Peter G. Waterman. "Flavanone, triterpene and chromene derivatives from the stems of Paramignya griffithii." Phytochemistry 55, no. 3 (2000): 269–73. http://dx.doi.org/10.1016/s0031-9422(00)00311-3.

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42

Xu, Qing-hui, Ji-zhen Li, Jiang-hua He, Xin Zhao, and Qi-sheng Huo. "Synthesis of novel flavanone derivatives and their anti Staphylococcus aureus evaluation." Chemical Research in Chinese Universities 29, no. 4 (2013): 695–98. http://dx.doi.org/10.1007/s40242-013-2519-7.

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43

Chand, Karam, Amir Nasrolahi Shirazi, Preeti Yadav, et al. "Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives." Canadian Journal of Chemistry 91, no. 8 (2013): 741–54. http://dx.doi.org/10.1139/cjc-2013-0053.

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A series of 6- and 8-cinnamoylchromen-2-one and dihydropyranochromen-2-one derivatives were synthesized and their antiproliferative activities were evaluated against three human cancer cell lines, i.e., ovarian adenocarcinoma (SK-OV-3), leukemia (CCRF-CEM), and breast carcinoma (MCF-7). In general, 8-cinnamoylchromen-2-one derivatives were found to have higher antiproliferative activity against the cancer cells when compared with 6-cinnamoyl analogues. Among all of the hybrid chromen-2-one − chalcone/flavanone compounds, a 7-hydroxy-8-cinnamoylchromen-2-one derivative 35 was found to be consis

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44

Stec, Katarzyna, Joanna Kozłowska, Anna Wróblewska-Kurdyk, Bożena Kordan, Mirosław Anioł, and Beata Gabryś. "Effect of Naringenin and Its Derivatives on the Probing Behavior of Myzus persicae (Sulz.)." Molecules 25, no. 14 (2020): 3185. http://dx.doi.org/10.3390/molecules25143185.

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Substances that alter insect behavior have attracted a lot of attention as potential crop protection agents. Naringenin (5,7,4′-trihydroxyflavanone) is a naturally occurring bioactive flavanone. We evaluated the influence of naringenin on aphid activities during individual phases of probing and feeding and the effect of structural modifications of naringenin on its activity towards aphids. We monitored the probing behavior of Myzus persicae (Sulz.) (Hemiptera: Aphididae) using the Electrical Penetration Graph (EPG) technique. The chemical modifications were the substitution of hydrogen atoms w

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45

Ali, Md Yousof, Susoma Jannat, Hyun-Ah Jung, and Jae-Sue Choi. "Structural Bases for Hesperetin Derivatives: Inhibition of Protein Tyrosine Phosphatase 1B, Kinetics Mechanism and Molecular Docking Study." Molecules 26, no. 24 (2021): 7433. http://dx.doi.org/10.3390/molecules26247433.

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In the present study, we investigated the structure-activity relationship of naturally occurring hesperetin derivatives, as well as the effects of their glycosylation on the inhibition of diabetes-related enzyme systems, protein tyrosine phosphatase 1B (PTP1B) and α-glycosidase. Among the tested hesperetin derivatives, hesperetin 5-O-glucoside, a single-glucose-containing flavanone glycoside, significantly inhibited PTP1B with an IC50 value of 37.14 ± 0.07 µM. Hesperetin, which lacks a sugar molecule, was the weakest inhibitor compared to the reference compound, ursolic acid (IC50 = 9.65 ± 0.0

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46

A. Yunes, Rosendo, Irene Messana, Franco Ferrari, Franco Delle Monache, and Eszter Gacs-Baitz. "Three New Flavanone Derivatives from the Root Bark of Sorocea bonplandii Baillon." HETEROCYCLES 38, no. 6 (1994): 1287. http://dx.doi.org/10.3987/com-94-6676.

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47

Pouget, Christelle, Catherine Fagnere, Jean-Philippe Basly, Gerard Habrioux, and Albert-José Chulia. "New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-Substituted flavanone derivatives." Bioorganic & Medicinal Chemistry Letters 12, no. 7 (2002): 1059–61. http://dx.doi.org/10.1016/s0960-894x(02)00072-0.

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48

Lee, Je-Hyuk. "In-vitro evaluation for antioxidant and anti-inflammatory property of flavanone derivatives." Food Bioscience 11 (September 2015): 1–7. http://dx.doi.org/10.1016/j.fbio.2015.03.003.

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49

Gu, Hong-shun, Xi Chen, Jian-wei Zhang, Lan Zhang, and Lin Li. "Synthesis and biological evaluation of novel flavanone derivatives as potential antipsychotic agents." Chemical Biology & Drug Design 89, no. 3 (2016): 353–64. http://dx.doi.org/10.1111/cbdd.12843.

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50

Ferlinahayati, Ferlinahayati, Yana Maolana Syah, Lia Dewi Juliawaty, and Euis Holisotan Hakim. "FLAVANONES FROM THE WOOD OF Morus nigra WITH CYTOTOXIC ACTIVITY." Indonesian Journal of Chemistry 13, no. 3 (2013): 205–8. http://dx.doi.org/10.22146/ijc.21277.

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Two flavanone derivatives, norartocarpanone (1) and euchrenone a7 (2) had been isolated for the first time from the methanol extract of the wood of Morus nigra. The structures of these compounds were determined base on spectral evidence, including UV, IR, and NMR. The first compound also confirmed by comparison with the reported data. Cytotoxic properties of these compounds were evaluated against murine leukemia P-388 cells. Euchrenone a7 (2) was found more cytotoxic than norartocarpanone (1) with their IC50 7.8 and 12.7 mg/mL respectively.

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