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Dissertations / Theses on the topic 'Flavivirus Infection'

Author: Grafiati

Published: 6 September 2023

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1

Gollins, S. W. "Mechanisms of flavivirus neutralization and cellular infection." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355752.

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2

Dejarnac, Ophélie. "Molecular and cellular basis of phosphatidylserine receptors mediated flavivirus infection." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC297/document.

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Le virus de la dengue (DENV) et le virus Zika (ZIKV) sont deux virus transmis par le moustique et responsables de maladies importantes chez l’Homme. En absence de vaccin et de traitements antiviraux efficaces, ces pathogènes représentent des problèmes de santé publique majeurs. Les bases moléculaires des interactions qu’établissent le DENV et ZIKV et la cellule hôte lors de l’entrée virale sont peu connues. Notre laboratoire a récemment identifié, les protéines TIM (TIM-1 et TIM-4) et TAM (Tyro3 et Axl), deux familles de récepteurs à la phosphatidylsérine (PtdSer) impliqués dans la reconnaissa

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3

Nguyen, Jennifer B. "Molecular Mechanisms of Host-Pathogen Interactions in Flavivirus and Hookworm Infection." Thesis, Yale University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3580786.

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<p> Microbial pathogens and their hosts have evolved complex adaptations to ensure their individual survival, resulting in a so-called "molecular arms race." While hosts may have acquired diverse mechanisms to protect themselves from the microbial invader, pathogens have developed elaborate strategies to evade and subvert these defenses. Viruses and hookworms are important pathogens which have evolved to successfully invade and infect their human hosts. Although structural biology has provided significant mechanistic insight into these processes of invasion, many specific host-pathogen interac

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4

Ottendorfer, Christy L. "Impact of West Nile virus on the natural history of St. Louis encephalitis virus in Florida." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002452.

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5

Desole, Giovanna. "Comparative analysis of Zika virus and other Flavivirus infection in human neural cells." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3424985.

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Background: Zika virus (ZIKV), West Nile virus (WNV) and dengue virus (DENV) are mosquito-borne flaviviruses that generally cause mild or asymptomatic disease in humans. However, ZIKV infection has been associated with fetal microcephaly and Guillain-Barrè syndrome in adults; WNV infection may evolve to severe neuroinvasive disease in the elderly and immunocompromised subjects; DENV may rarely cause neurological complications in infected individuals. In addition, another emerging mosquito-borne flavivirus, Usutu virus (USUV), which may cause fatal neuroinvasive disease in different bird specie

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6

Rückert, Claudia. "Alphavirus and flavivirus infection of Ixodes tick cell lines : an insight into tick antiviral immunity." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10063.

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Arthropod-borne viruses, arboviruses, have the ability to replicate in both vertebrates and invertebrates and are transmitted to susceptible vertebrate hosts by vectors such as mosquitoes and ticks. Ticks are important vectors of many highly pathogenic arboviruses, including the flavivirus tick-borne encephalitis virus (TBEV) and the nairovirus Crimean-Congo haemorrhagic fever virus. In contrast, alphaviruses are principally mosquito-borne and have been isolated only rarely from ticks; ticks have not been implicated as their vectors. Nevertheless, the alphavirus Semliki Forest virus (SFV) repl

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7

Youseff, Brian. "The Role of Tumor Necrosis Factor Receptor-Associated Factor 6 in Tick-Borne Flavivirus Infection." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco155691388498993.

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8

Pettersson, John H. O. "The Origin of the Genus Flavivirus and the Ecology of Tick-Borne Pathogens." Doctoral thesis, Uppsala universitet, Systematisk biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211090.

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The present thesis examines questions related to the temporal origin of the Flavivirus genus and the ecology of tick-borne pathogens. In the first study, we date the origin and divergence time of the Flavivirus genus. It has been argued that the first flaviviruses originated after the last glacial maximum. This has been contradicted by recent analyses estimating that the tick-borne flaviviruses emerged at least before 16,000 years ago. It has also been argued that the Powassan virus was introduced into North America at the time between the opening and splitting of the Beringian land bridge. Su

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9

Courtney, Sean C. "Functional Analysis of Host Cell Proteins and Stress Responses that Inhibit West Nile Virus Infection." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/101.

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Resistance to flavivirus-induced disease is conferred by a single gene that encodes oligoadenylate synthetase (Oas) 1b (Oas1b). Oas1b is not a functional synthetase suggesting its anti-flavivirus mechanism is RNase L-independent and that it may be mediated by interactions with other host cell protein(s). A yeast two-hybrid screen was used to identify host cell binding partners of Oas1b. Candidate partners were confirmed by yeast co-transformation and co-immunoprecipitation analyses. Oxysterol binding protein-related 1L (ORP1L) and ATP binding cassette subfamily F 3 (ABCF3) were found to intera

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10

Riccetti, Silvia. "In vitro modelling of patient-specific susceptibility to neurotropic flavivirus infection by using induced pluripotent stem cells." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422230.

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Background: A characteristic feature of many infections is that only a portion of exposed individuals develop clinical disease. These include mosquito-borne flaviviruses such as West Nile virus (WNV), Zika virus (ZIKV) and Usutu virus (USUV) infections, which generally cause mild illness or asymptomatic infections in humans. Nonetheless, WNV can cause serious neuroinvasive diseases in less than 1% of infected patients, mainly elderly and immunocompromised subjects; ZIKV may cause fetal microcephaly in about 5% of infections acquired during pregnancy and 1 in 10,000 infected adults develop Guil

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11

Asghar, Naveed. "Ticks and Tick-borne Encephalitis Virus : From Nature to Infection." Doctoral thesis, Södertörns högskola, Miljövetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-31153.

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Vector-borne diseases are an increasing global threat to humans due to climate changes, elevating the risk of infections transmitted by mosquitos, ticks, and other arthropod vectors. Ixodes ricinus, a common tick in Europe, transmits dangerous tick-borne pathogens to humans. Tick-borne encephalitis (TBE) is a vector-borne disease caused by TBE virus (TBEV). Climate change has contributed to increased tick abundance and incidence of tick-borne diseases, and between 10,000 and 15,000 human TBE cases are reported annually in Europe and Asia. TBEV shows a patchy geographical distribution pattern w

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12

Pinho, dos Reis Vinícius [Verfasser], Rainer G. [Akademischer Betreuer] Ulrich, Martin H. [Akademischer Betreuer] Groschup, Markus [Akademischer Betreuer] Keller, Rainer G. [Gutachter] Ulrich, and Stefanie [Gutachter] Becker. "The role of integrins in flavivirus infection / Vinícius Pinho dos Reis ; Gutachter: Rainer G. Ulrich, Stefanie Becker ; Rainer G. Ulrich, Martin H. Groschup, Markus Keller." Greifswald : Ernst-Moritz-Arndt-Universität, 2019. http://d-nb.info/117724151X/34.

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13

Reis, Vinicius Pinho dos [Verfasser], Rainer G. [Akademischer Betreuer] Ulrich, Martin H. [Akademischer Betreuer] Groschup, Markus [Akademischer Betreuer] Keller, Rainer G. [Gutachter] Ulrich, and Stefanie [Gutachter] Becker. "The role of integrins in flavivirus infection / Vinícius Pinho dos Reis ; Gutachter: Rainer G. Ulrich, Stefanie Becker ; Rainer G. Ulrich, Martin H. Groschup, Markus Keller." Greifswald : Ernst-Moritz-Arndt-Universität, 2019. http://d-nb.info/117724151X/34.

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14

Reis, Vinicius Pinho dos [Verfasser], Rainer G. [Akademischer Betreuer] Ulrich, Martin H. [Akademischer Betreuer] Groschup, Markus [Akademischer Betreuer] Keller, Rainer G. Gutachter] Ulrich, and Stefanie [Gutachter] [Becker. "The role of integrins in flavivirus infection / Vinícius Pinho dos Reis ; Gutachter: Rainer G. Ulrich, Stefanie Becker ; Rainer G. Ulrich, Martin H. Groschup, Markus Keller." Greifswald : Ernst-Moritz-Arndt-Universität, 2019. http://d-nb.info/117724151X/34.

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15

Izuogu, Adaeze O. Izuogu. "Restriction of tick-borne flaviviruses in the white-footed mouse." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1501786858639212.

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16

McAtamney, Sarah. "Investigation of Dengue Fever Virus Envelope Glycoprotein Carbohydrate-Ligand Recognition Events Essential for Mammalian Cell Infection." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366363.

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Dengue Fever virus (DENV) is a very old mosquito-borne flavivirus that has made a modern worldwide re-emergence as a result of population movement and growth, urbanisation and lapse of vector control. The World Health Organisation estimates that 2.5 billion people, or two-fifths of the world’s population are at risk from DENV, which can cause serious illness and in its severe forms, death. Despite the humanitarian and economic burden that DENV and its flaviviral relatives create, there are no chemotherapeutic drugs available and vaccine development is challenging. Mammalian host cell infection

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17

Grard, Gilda. "Génomique et évolution des flavivirus transmis par les tiques et découverte d'un nouveau lignage du genre flavivirus." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20679.

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18

Scaramozzino, Natale. "Flavivirus : étude d'une cible diagnostique, la région NS codant pour la polymérase et d'une cible thérapeutique, la protéase NS3 du virus Langat." Université Joseph Fourier (Grenoble), 2002. http://www.theses.fr/2002GRE19004.

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Les flavivirus sont des virus responsables d'une considérable morbidité et mortalité dans le monde en causant des encéphalites sévères, des fièvres hémorragiques, ainsi que des symptômes fébriles chez l'homme. L'absence de symptômes cliniques spécifiques pour une infection liée à un virus donné, et la présence simultanée de différents arbovirus dans une même région impose la nécessité de disposer d'un diagnostic de genre par PCR. Parmi les amorces proposées dans la littérature, une seule paire a permis la détection des différents flavivirus testés avec une sensibilité limite de 105 doses infec

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19

Defrocourt, Christophe. "L'encéphalite japonaise en 2003 : épidémiologie et nouvelles perspectives de vaccin." Rouen, 2004. http://www.theses.fr/2004ROUEP008.

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L'encéphalite japonaise est une maladie croissante en Asie du Sud-Est et dans les pays du Pacifique occidental puisqu'elle s'étend aujourd'hui à l'Australie et à la Russie. Elle est actuellement la première cause d'encéphalite virale en Asie et se rencontre surtout en zone rurale. Cette maladie est provoquée par un virus de la famille des Flavivirus. Elle est véhiculée par une piqûre de moustique de la famille des Culex. Les porcs et les oiseaux aquatiques ont un rôle de réservoirs dans la transmission de la maladie et seule leur augmentation explique la transmission à l'homme, puisqu'e celui-

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20

Terrien, Vincent Alliot Anne. "Les culicidés transmission vectorielle des infections et parasitoses à l'homme /." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=46631.

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21

Rechoum, Yassine. "Détection de séquences d'ARN du VHC dans des extraits de moustiques du genre Aedes : étude cinétique après infections expérimentales." Grenoble 1, 2009. http://www.theses.fr/2009GRE10205.

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Dans le but d'explorer la capacité des moustiques à répliquer le VHC, nous avons réalisé une série d'infections expérimentales sur Aede caspius, Aedes vexans et genre Cu/ex pipiens sauvage et d'élevage. Après collecte des moustiques, les femelles ont été nourries par un repas sanguin virémique (VHC 1 b positif). Les moustiques ont ensuite été maintenus en élevage pendant plusieurs jours. Après mise au point des conditions de détection, nous avons réussi à apporter la preuve de la réplication du VHC dans les moustiques du genre Aedesvexans. Dans la première infection expérimentale réalisée sur

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22

Bessaud, Maël. "Etude in vitro du complexe protéasique [NS2B/NS3] des flavivirus, cible potentielle de molécules antivirales." Aix-Marseille 2, 2005. http://theses.univ-amu.fr.lama.univ-amu.fr/2005AIX22027.pdf.

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23

Brandler, Samantha. "Etude du mécanisme d'inhibition de la fusion des flavivirus par les anticorps et mise au point d'un candidat vaccin contre la dengue basé sur l'expression d'un antigène d'enveloppe par un vecteur dérivé du vaccin contre la rougeole." Aix-Marseille 1, 2008. http://theses.univ-amu.fr.lama.univ-amu.fr/2008AIX11003.pdf.

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La dengue est une maladie ré-émergente qui menace le tiers de la population mondiale, et pour laquelle aucun vaccin n'est disponible. Dans ce travail, nous avons évalué une nouvelle stratégie de vaccination basée sur l'expression d'un antigène combiné du virus de la dengue par un vecteur dérivé du vaccin vivant atténué pédiatrique contre la rougeole. La compréhension des mécanismes de neutralisation des flavivirus par les anticorps est essentielle pour la conception d’approches vaccinales innovantes contre la dengue. C’est pourquoi, dans un premier temps, nous avons étudié le mécanisme de l’in

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24

Michel, Friederike [Verfasser]. "Monitoring and pathogenesis of flavivirus infections in wild birds and domestic poultry in Germany / Friederike Michel." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1201644364/34.

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25

Kles, Virginie. "Contribution à l'étude des arboviroses sur l'Ile de la Réunion : enquête séro-épidémiologique." Brest, 1993. http://www.theses.fr/1993BRES2027.

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Une étude de la séroprévalence des arboviroses à flaviviridae a été entreprise sur l'île de la Réunion. Deux mille cinq cent sept sérums humains, prélevés en 1987 sur un échantillon randomisé de la population réunionnaise, ont été testés à l'aide de la réaction d'inhibition de l'hémagglutination vis-à-vis des 5 antigènes suivants: fièvre jaune, dengue de type 1, dengue de type 2, West Nile et Wesselsbron. Cent treize sérums provenant de diverses espèces animales, récoltés en 1989, ont été étudiés avec la même technique et la même batterie d'antigènes. Des commémoratifs individuels, recueillis

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26

Arnal, Audrey. "Circulation d'agents pathogènes en populations naturelles : approches éco-épidémiologiques chez le Goéland leucophée (Larus michaellis)." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20139/document.

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L'émergence des zoonoses est à relier directement avec les perturbations générées par l'Homme sur son environnement naturel à plus ou moins grande échelle. Sur l'ensemble des zoonoses émergentes chez l'Homme, la majorité provient d'animaux sauvages. L'étude du rôle de la faune sauvage dans la circulation des agents pathogènes est donc cruciale en particulier quand les interfaces faune sauvage/Homme sont fortes. L'objectif de cette thèse a été de comprendre par des approches éco-épidémiologiques à large échelle, la circulation d'agents pathogènes dans les populations d'un oiseau sauvage en cont

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Baidaliuk, Artem. "Interactions between the insect-specific flavivirus CFAV, its mosquito host aedes aegypti, and co-infecting arboviruses." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS494.pdf.

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Les virus de la dengue (DENV) et du Zika (ZIKV) sont des virus transmis par les moustiques qui causent de graves problèmes de santé publique à travers le monde. Ces virus transmis par des arthropodes (arbovirus) sont des virus à ARN du genre Flavivirus principalement transmis à l'homme par le moustique Aedes aegypti. De plus, les moustiques Ae. aegypti sont naturellement infectés par le cell-fusing agent virus (CFAV), le premier flavivirus spécifique d'insecte (FSI) ayant été décrit. L'évolution du CFAV, ses interactions avec les arbovirus chez les moustiques co-infectés et les réponses immuni

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28

CARLETTI, TEA. "The Unfolded Protein Response is required early during TBEV infection to trigger the interferon response." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908030.

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Flaviviruses are a major cause of disease in humans and animals worldwide. Tick-borne encephalitis virus (TBEV) is the most relevant arthropod-borne flavivirus endemic in Europe and is the etiological agent of tick-borne encephalitis, a potentially fatal infection of the central nervous system. In our recent work we demonstrated that TBEV is able to trigger the stress response of infected cells leading to the formation of stress granules (SG) (Albornoz et al. 2014). We also found that the formation of SG in TBEV infected cells is delayed, following the same delayed kinetic of the IFN response

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29

Beck, Cécile. "Nouvelles stratégies diagnostiques et thérapeutiques contre les flavivirus neurotropes en médecine vétérinaire." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS083/document.

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Les flavivirus ayant un impact en médecine vétérinaire sont largement distribués dans le monde (à l’exemple de la fièvre West Nile (WNF) présente sur les cinq continents ou de l’Encéphalite japonaise (EJ) en Asie du Sud-Est) et sont responsables de maladies à dominante neurologique chez l’homme et/ou le cheval.La virémie étant généralement brève lors de ces infections virales, les méthodes de diagnostic utilisées sont essentiellement sérologiques. Or le chevauchement fréquent des aires de répartition des flavivirus complique le diagnostic sérologique. En effet, des réactions sérologiques crois

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30

Bates, Tyler Alexander. "Usutu Virus: An Emerging Arbovirus Threat." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/102268.

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Mosquito-borne viruses, such as dengue virus (DENV), Zika virus (ZIKV), chikungunya virus (CHIKV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and West Nile virus (WNV) are major threats to global public health resulting in millions of infections and hundreds of thousands of deaths annually. The presence of these viruses and their increasing emergence/spread continues to escalate. Notably, Usutu virus (USUV; Genus: Flavivirus; Family: Flaviviridae) is one such pathogen currently causing mass die-offs of avian hosts throughout Europe. USUV is categorized in the Japanese Enc

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Frank, Jordan C. "Development and Application of a Reverse Genetics System for Zika Virus." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7280.

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Zika virus (ZIKV) has emerged in many regions of the world, with infection outcomes spanning from no apparent illness to crippling nervous system disease. ZIKV and its close relatives, West Nile virus, Japanese encephalitis virus, dengue virus, and yellow fever virus are primarily transmitted by mosquitoes. Three ZIKVs were selected: MR-766 (Uganda, 1947), P6-740 (Malaysia, 1966), and PRVABC-59 (Puerto Rico, 2015), whose place of origin and time of isolation differ substantially. Stable, complementary DNA (cDNA) copies of the three ZIKV RNA genomes were cloned to examine the significance of vi

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Kortenhoeven, Cornell. "Genomics of West Nile viruses from South Africa." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/32944.

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West Nile Virus (WNV) forms part of the Japanese encephalitis serocomplex in the genus Flavivirus, family Flaviviridae. This enveloped positive single-stranded RNA (+ssRNA ) virus is the etiological agent of West Nile fever, and in more severe cases WNV neuroinvasive disease, in both humans and animals. WNV is distributed worldwide and is phylogenetically classified into five distinct lineages. The WNV genome is ~11 Kb in length and encodes a single open reading frame (ORF) that is post-translationally cleaved into three structural proteins and seven non-structural proteins. In this study, two

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33

Zidane, Nora. "Remaniements rationnel de la protéine d'enveloppe virale et de ses domaines pour la détection des infections à flavivirus et l'étude d'interactions avec ses récepteurs." Paris 7, 2013. http://www.theses.fr/2013PA077149.

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La protéine d'enveloppe des Flavivirus comprend 3 ectodomaines et un segment membranaire. J'ai caractérisé les propriétés de son domaine III (ED3) in vitro. J'ai mesuré la stabilité thermodynamiques d'ED3 par des expériences d'équilibres de dépliement, induits chimiquement ou thermiquement, et suivis par spectrofluorimétrie; augmenté la stabilité d'ED3 par des changements de résidus dans son coeur hydrophobe sans affecter son antigénicité; et montré qu'un domaine ED3 consensus des virus de la dengue (DENV) était hautement stable. La Protéine Ribosomale SA (RPSA) humaine comprend un domaine N-t

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Baronti, Cécile. "Etude de Flavivirus : epidémiologie moléculaire en Bolivie et Analyse de leur interaction sur la réponse interféron dépendante du TLR3." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20664/document.

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Le genre Flavivirus regroupe plus de 70 espèces dont plusieurs sont des pathogènes humains de première importance responsables dans les formes les plus graves de manifestations hémorragiques ou d’encéphalites parfois mortelles. L’absence de traitements antiviraux spécifiques et l’augmentation croissante des flaviviroses, surtout dans les régions tropicales, justifient un effort de recherche et développement pour lutter contre ces maladies.Ce travail a abordé deux aspects de l’infection à flavivirus : un aspect épidémiologique et un aspect plus fondamental sur l’immunité innée et les contremesu

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35

Grillo, Elena. "Presence of Haemosporidia and Flaviviruses in Breeding Prothonotary Warblers (Protonotaria citrea): An Analysis of Spatial and Temporal Trends in Infection Prevalence and Associations with Reproductive Success." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1857.

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As Neotropical migratory birds, Prothonotary Warblers are exposed to parasites in both tropical and temperate regions and may act as dispersal agents between geographic areas. This study identifies the prevalence of Haemosporidia, West Nile Virus (WNV), and St. Louis Encephalitis virus (SLEV) in this species. A total of 71.6% of captured Prothonotary Warblers were infected with Haemosporidia during the 2008 breeding season, and infection prevalence increased throughout the season. This temporal change in prevalence is likely due to infection relapse and transmission of new infections. No c

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Fares, Mazigh. "Modélisation pathologique de l'infection par le virus de l'encéphalite à tiques et réponse antivirale induite dans les neurones et astrocytes dérivées de progéniteurs neuraux foetaux humains." Thesis, Paris, Institut agronomique, vétérinaire et forestier de France, 2018. http://www.theses.fr/2018IAVF0025.

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Le virus de l’encéphalite à tiques (TBEV), membre de la famille des Flaviviridae et du genre Flavivirus, est d’un point de vue médical, l’arbovirus plus important en Europe et en Asie du Nord-Est. Il est responsable de symptômes fébriles et de manifestations neurologiques allant de la méningite légère à l'’encéphalomyélite sévère pouvant être fatale. En dépit de son importance médicale, la neuropathogenèse induite par TBEV reste peu caractérisée. Ici, nous avons utilisé des cellules neurales humaines différenciées à partir de progéniteurs neuraux fœtaux pour modéliser l’infection in vitro et é

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37

Jansson, Anna M. "Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis." Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196623.

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The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections. Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. However, the mechanism behind this is currently unknown. Here we present the first nsp1 structure from an alphacoronavirus, Transmissible gastroenteritis virus (TGEV) nsp1. Contrary to previous speculation, the TGEV nsp1 structure clearly shows that alpha- and betacoronavirus nsp1s have a common e

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Houé, Vincent. "Characterization of non-retroviral integrated RNA virus sequences (NIRVS) in Aedes albopictus populations and Relation with vector competence." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS139.

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Aedes albopictus est un vecteur de transmission d’arbovirus, et ceci fait de lui une sérieuse menace. Durant la dernière décennie, NIRVS (séquences intégrées de virus à ARN non-rétroviraux) issues de Flavivirus spécifiques d’insectes (FSIs) ont été découvert intégrées dans le génome du moustique Aedes albopictus il y a très longtemps. De plus, il a été montré que ces éléments pourraient avoir un rôle antiviral chez le vecteur par la production de piARNs qui réduirait la réplication virale. Ici nous avons caractérisé 8 NIRVS chez 12 populations naturelles d’Aedes albopictus. Nous montrons qu’il

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Lourenço, José. "Unifying the epidemiological, ecological and evolutionary dynamics of Dengue." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:cb4db8dd-5467-4c6e-8d3e-3e0fe738bc0a.

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In under 6 decades dengue has emerged from South East Asia to become the most widespread arbovirus affecting human populations. Recent dramatic increases in epidemic dengue fever have mainly been attributed to factors such as vector expansion and ongoing ecological, climate and socio-demographic changes. The failure to control the virus in endemic regions and prevent global spread of its mosquito vectors and genetic variants, underlines the urgency to reassess previous research methods, hypotheses and empirical observations. This thesis comprises a set of studies that integrate currently negle

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Miot, Elliott. "Potential of the mosquito Aedes malayensis as an arbovirus vector in South East Asia." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS548.

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De nombreux virus transmis par les arthropodes (arbovirus), tels que ceux de la dengue (DENV) et de la fièvre jaune (YFV), circulaient à l’origine dans des cycles selvatiques et ont émergé chez l’Homme via des moustiques « bridge vectors » qui connectent les cycles de transmission selvatiques et humains. Ces « bridge vectors » peuvent aussi par transfert inverse établir de nouveaux cycles selvatiques. Cette thèse a évalué le potentiel de vecteur d’arbovirus d’un moustique répandu en Asie du sud-est, Aedes malayensis. Nous avons identifié Ae. malayensis pour la première fois au Laos lors de cap

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Uren, M. F. "Helper T cells in flavivirus infection." Phd thesis, 1987. http://hdl.handle.net/1885/142617.

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Lin, Chi-Ping, та 林啟平. "To Study the Role of eIF2α Phosphorylation in Flavivirus Infection". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/tp99ew.

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碩士<br>國防醫學院<br>微生物及免疫學研究所<br>102<br>Japanese encephalitis virus (JEV) and dengue virus (Den) are flaviviruses whose genome is a single-stranded, positive-sense RNA with 5’ cap but without 3’ poly-A tail. After viral entry and uncoating, translation of flaviviral RNA is initiated by the host mRNA translation machineries. Cellular cap-dependent mRNA translation is tightly controlled by phosphorylation of eukaryotic initiation factor 2 α subunit (eIF2α) at residue Ser51. In response to certain stress condition, eIF2α can be phosphorylated by at least four different cellular kinases, for example P

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Chang, Tsung-Hsien, and 張聰賢. "The Mechanisms of Interferon-beta Gene Expression Induced by Flavivirus Infection." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/88203434422341098905.

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博士<br>國防醫學院<br>生命科學研究所<br>93<br>In this study, we found that infection with flaviviruses, such as Japanese encephalitis virus (JEV) and Dengue virus serotype 2 (DEN-2), leads to interferon-beta (IFN-beta) gene expression in a virus-replication- and de novo protein-synthesis-dependent manner. NF-kappa B activation is essential for IFN-beta induction in JEV- and DEN-2-infected cells. However, these two viruses seem to preferentially target different members of the interferon regulatory factor (IRF) family. The activation of constitutively expressed IRF-3, characterized by slower gel mobility, di

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Chien, Hsuling, and 簡旭伶. "The roles of host cellular RNA-binding proteins on flavivirus infection." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/68947129120918829837.

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博士<br>國防醫學院<br>生命科學研究所<br>100<br>The untranslated regions (UTRs) located at the 5and 3 ends of the Japanese encephalitis virus (JEV) genome, a positive-sense RNA, are involved in viral translation, the initiation of RNA synthesis, and the packaging of nascent virions. The cellular and viral proteins that participate in these processes are expected to interact with the UTRs. In this study, we used biotinylated RNA-protein pulldown and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analyses to identify that the far upstream element (FUSE) binding protein 1 (FBP1) binds wi

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"Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection." Tulane University, 2020.

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archives@tulane.edu<br>Zika virus (ZIKV), a member of the Flaviviridae family, was the cause of a large viral outbreak reaching across the Americas during 2015 and 2016. Discovered in 1947, it has historically been a neglected disease, due to its emergence in humans on a large scale being recent. At the time of the outbreak, no FDA approved ZIKV diagnostics existed, and those that were able to detect the virus were unable to distinguish it from related viruses such as Dengue virus (DENV), and at this time, no approved therapeutics or vaccines are available. We investigated the ability of diagn

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"Vaccination Strategy To Protect Against Flavivirus Infection Based On Recombinant Measles Vaccine." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.40803.

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abstract: Despite the approval of a Dengue virus (DV) vaccine in five endemic countries, dengue prevention would benefit from an immunization strategy highly immunogenic in young infants and not curtailed by viral interference. Problematically, infants younger than 9 year of age, whom are particularly prone to Dengue severe infection and death, cannot be immunized using current approved DV vaccine. The most important issues documented so far are the lack of efficiency and enhancement of the disease in young seronegative recipients, as well as uneven protection against the four DV serotypes. Ba

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Chiu, Wei-Tzu, and 邱唯慈. "To study the potential modulation effect of cellular microRNA on flavivirus infection." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75479753331429099807.

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碩士<br>國防醫學院<br>微生物及免疫學研究所<br>98<br>MicroRNAs (miRNAs) are small noncoding RNAs of approximately 21~23 nucleotides in length. They are derived from cellular or viral transcripts and bind to their target mRNAs in a sequence-specific manner, resulting in either mRNA degradation or translational repression. Recent studies suggest that cellular miRNAs are among the key determinants controlling virus infection in mammalian hosts, for example cellular miRNAs can serve as restriction factors to limit infection by several viruses, including human immunodeficiency virus and vesicular stomatitis virus. H

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Regner, Matthias. "The cytotoxic T Cell response to flavivirus infection : immunodominance and cross-reactivities." Phd thesis, 2000. http://hdl.handle.net/1885/147169.

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Lee, Chyan-Jang, and 李乾彰. "I. Flavivirus Activates Phosphatidylinositol 3-Kinase Signaling to Block Caspase-Dependent Apoptotic Cell Death at The Early Stage of Virus InfectionII. The Roles of Cholesterol on Flavivirus Infection." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/75558075014203945874.

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博士<br>國防醫學院<br>生命科學研究所<br>93<br>Flaviviruses such as dengue virus (DEN) and Japanese encephalitis virus (JEV) are medically important in humans. The lipid kinase, phosphatidylinositol 3-kinase (PI3K) and its downstream target Akt have been implicated in the regulation of diverse cellular functions such as proliferation, and apoptosis. As JEV and DEN appear to trigger apoptosis in cultured cells at a rather late stage of infection, we evaluated the possible roles of the PI3K/Akt signaling pathway in flavivirus-infected cells. We found that Akt phosphorylation was noticeable in the JEV- and DEN

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Pan, Hsuan-Fan, and 潘璿帆. "Study of inhibitory effects of flavivirus infection by the extracts of the Ulva lactuca." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/01969503975163751629.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>95<br>Viral infectious diseases caused by arthropod-borne flaviviruses have been gradually increased worldwide in recent years, especially including dengue virus (DEN) and Japanese encephalitis virus (JEV) prevalent in Taiwan and other South Asia countries. Dengue viruses cause dengue fever and dengue related diseases that represent a global public health problem. Seaweeds have known to possess an ingredient of sulfated polysaccharides that have been widely used as curative agents for anti-virus, anti-tumor, anti-oxidation, anti-coagulant, and control of normal chole

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