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Journal articles on the topic 'Flavivirus – Transmission'

Author: Grafiati

Published: 19 October 2024

Last updated: 31 July 2025

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1

Zhang, Xianwen, Yuhan Li, Yingyi Cao, Ying Wu, and Gong Cheng. "The Role of Noncoding RNA in the Transmission and Pathogenicity of Flaviviruses." Viruses 16, no. 2 (2024): 242. http://dx.doi.org/10.3390/v16020242.

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Noncoding RNAs (ncRNAs) constitute a class of RNA molecules that lack protein-coding capacity. ncRNAs frequently modulate gene expression through specific interactions with target proteins or messenger RNAs, thereby playing integral roles in a wide array of cellular processes. The Flavivirus genus comprises several significant members, such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV), which have caused global outbreaks, resulting in high morbidity and mortality in human populations. The life cycle of arthropod-borne flaviviruses encompasses their transmission betwee

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2

Habarugira, Gervais, Jasmin Moran, Jessica J. Harrison, et al. "Evidence of Infection with Zoonotic Mosquito-Borne Flaviviruses in Saltwater Crocodiles (Crocodylus porosus) in Northern Australia." Viruses 14, no. 5 (2022): 1106. http://dx.doi.org/10.3390/v14051106.

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The risk of flavivirus infections among the crocodilian species was not recognised until West Nile virus (WNV) was introduced into the Americas. The first outbreaks caused death and substantial economic losses in the alligator farming industry. Several other WNV disease episodes have been reported in crocodilians in other parts of the world, including Australia and Africa. Considering that WNV shares vectors with other flaviviruses, crocodilians are highly likely to also be exposed to flaviviruses other than WNV. A serological survey for flaviviral infections was conducted on saltwater crocodi

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Göertz, G. P., J. J. Fros, P. Miesen, et al. "Noncoding Subgenomic Flavivirus RNA Is Processed by the Mosquito RNA Interference Machinery and Determines West Nile Virus Transmission by Culex pipiens Mosquitoes." Journal of Virology 90, no. 22 (2016): 10145–59. http://dx.doi.org/10.1128/jvi.00930-16.

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ABSTRACT Flaviviruses, such as Zika virus, yellow fever virus, dengue virus, and West Nile virus (WNV), are a serious concern for human health. Flaviviruses produce an abundant noncoding subgenomic flavivirus RNA (sfRNA) in infected cells. sfRNA results from stalling of the host 5′-3′ exoribonuclease XRN1/Pacman on conserved RNA structures in the 3′ untranslated region (UTR) of the viral genomic RNA. sfRNA production is conserved in insect-specific, mosquito-borne, and tick-borne flaviviruses and flaviviruses with no known vector, suggesting a pivotal role for sfRNA in the flavivirus life cycl

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4

Cook, Shelley, Shannon N. Bennett, Edward C. Holmes, Reine De Chesse, Gregory Moureau, and Xavier de Lamballerie. "Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico." Journal of General Virology 87, no. 4 (2006): 735–48. http://dx.doi.org/10.1099/vir.0.81475-0.

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The genus Flavivirus contains approximately 70 single-stranded, positive-sense RNA viruses that are mosquito-borne, tick-borne or have no known vector. Two discoveries support previous suggestions of the existence of a large number of unsampled flaviviruses: (i) a new flavivirus, Kamiti River virus, was recently isolated from Kenyan mosquitoes, and (ii) sequences with high similarity to those of flaviviruses have been found integrated into the genome of Aedes mosquitoes, suggesting a past infection with a virus (or viruses) that has yet to be discovered. These sequences were related most close

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5

Blitvich, Bradley J., and Andrew E. Firth. "A Review of Flaviviruses that Have No Known Arthropod Vector." Viruses 9, no. 6 (2017): 154. https://doi.org/10.5281/zenodo.13530565.

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(Uploaded by Plazi for the Bat Literature Project) Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles. Flaviviruses maintained by vertebrate-only transmission are commonly referred to as no known vector (NKV) flaviviruses. Fourteen species and two subtypes of NKV flaviviruses are recognized by the International Committee on Taxonomy of Viruses (ICTV), and Tamana bat virus potentially belongs to this group. NKV flaviviruses have been isolated i

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Blitvich, Bradley J., and Andrew E. Firth. "A Review of Flaviviruses that Have No Known Arthropod Vector." Viruses 9, no. 6 (2017): 154. https://doi.org/10.5281/zenodo.13530565.

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(Uploaded by Plazi for the Bat Literature Project) Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles. Flaviviruses maintained by vertebrate-only transmission are commonly referred to as no known vector (NKV) flaviviruses. Fourteen species and two subtypes of NKV flaviviruses are recognized by the International Committee on Taxonomy of Viruses (ICTV), and Tamana bat virus potentially belongs to this group. NKV flaviviruses have been isolated i

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7

Pandit, Pranav S., Megan M. Doyle, Katrina M. Smart, Cristin C. W. Young, Gaylen W. Drape, and Christine K. Johnson. "Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses." Nature Communications 9, no. 1 (2018): 5425. https://doi.org/10.5281/zenodo.13511315.

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(Uploaded by Plazi for the Bat Literature Project) Abstract Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood. Here we identify potential sylvatic reservoirs of flaviviruses and characterize the macro-ecological traits common to known wildlife hosts to predict the risk of sylvatic flavivirus transmission among wildlife and identify regions that could be vulnerable to outbreaks. We evaluate var

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Pandit, Pranav S., Megan M. Doyle, Katrina M. Smart, Cristin C. W. Young, Gaylen W. Drape, and Christine K. Johnson. "Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses." Nature Communications 9, no. 1 (2018): 5425. https://doi.org/10.5281/zenodo.13511315.

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(Uploaded by Plazi for the Bat Literature Project) Abstract Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood. Here we identify potential sylvatic reservoirs of flaviviruses and characterize the macro-ecological traits common to known wildlife hosts to predict the risk of sylvatic flavivirus transmission among wildlife and identify regions that could be vulnerable to outbreaks. We evaluate var

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9

Pandit, Pranav S., Megan M. Doyle, Katrina M. Smart, Cristin C. W. Young, Gaylen W. Drape, and Christine K. Johnson. "Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses." Nature Communications 9, no. 1 (2018): 5425. https://doi.org/10.5281/zenodo.13511315.

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(Uploaded by Plazi for the Bat Literature Project) Abstract Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood. Here we identify potential sylvatic reservoirs of flaviviruses and characterize the macro-ecological traits common to known wildlife hosts to predict the risk of sylvatic flavivirus transmission among wildlife and identify regions that could be vulnerable to outbreaks. We evaluate var

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10

Pandit, Pranav S., Megan M. Doyle, Katrina M. Smart, Cristin C. W. Young, Gaylen W. Drape, and Christine K. Johnson. "Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses." Nature Communications 9, no. 1 (2018): 5425. https://doi.org/10.5281/zenodo.13511315.

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(Uploaded by Plazi for the Bat Literature Project) Abstract Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood. Here we identify potential sylvatic reservoirs of flaviviruses and characterize the macro-ecological traits common to known wildlife hosts to predict the risk of sylvatic flavivirus transmission among wildlife and identify regions that could be vulnerable to outbreaks. We evaluate var

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11

Vasilakis, Nikos, and Scott C. Weaver. "Flavivirus transmission focusing on Zika." Current Opinion in Virology 22 (February 2017): 30–35. http://dx.doi.org/10.1016/j.coviro.2016.11.007.

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12

Wang, Hong-Jiang, Xiao-Feng Li, Long Liu, et al. "The Emerging Duck Flavivirus Is Not Pathogenic for Primates and Is Highly Sensitive to Mammalian Interferon Antiviral Signaling." Journal of Virology 90, no. 14 (2016): 6538–48. http://dx.doi.org/10.1128/jvi.00197-16.

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ABSTRACTFlaviviruses pose a significant threat to both animals and humans. Recently, a novel flavivirus, duck Tembusu virus (DTMUV), was identified to be the causative agent of a serious duck viral disease in Asia. Its rapid spread, expanding host range, and uncertain transmission routes have raised substantial concerns regarding its potential threats to nonavian hosts, including humans. Here, we demonstrate that DTMUV is not pathogenic for nonhuman primates and is highly sensitive to mammal type I interferon (IFN) signaling.In vitroassays demonstrated that DTMUV infected and replicated effici

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13

Kading, Rebekah C., and Tony Schountz. "Flavivirus Infections of Bats: Potential Role in Zika Virus Ecology." American Journal of Tropical Medicine and Hygiene 95, no. 5 (2016): 993–96. https://doi.org/10.5281/zenodo.13531441.

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(Uploaded by Plazi for the Bat Literature Project) Understanding the vector and nonhuman vertebrate species contributing to Zika virus (ZIKAV) transmission is critical to understanding the ecology of this emerging arbovirus and its potential to establish in new geographic areas. This minireview summarizes what is known regarding the association of bats with flaviviruses (Flaviviridae: Flavivirus) with a particular emphasis on the potential role of bats in the sylvatic transmission of ZIKAV. Key research directions that remain to be addressed are also discussed.

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Kading, Rebekah C., and Tony Schountz. "Flavivirus Infections of Bats: Potential Role in Zika Virus Ecology." American Journal of Tropical Medicine and Hygiene 95, no. 5 (2016): 993–96. https://doi.org/10.5281/zenodo.13531441.

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(Uploaded by Plazi for the Bat Literature Project) Understanding the vector and nonhuman vertebrate species contributing to Zika virus (ZIKAV) transmission is critical to understanding the ecology of this emerging arbovirus and its potential to establish in new geographic areas. This minireview summarizes what is known regarding the association of bats with flaviviruses (Flaviviridae: Flavivirus) with a particular emphasis on the potential role of bats in the sylvatic transmission of ZIKAV. Key research directions that remain to be addressed are also discussed.

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15

Göertz, Giel P., Joyce W. M. van Bree, Anwar Hiralal, et al. "Subgenomic flavivirus RNA binds the mosquito DEAD/H-box helicase ME31B and determines Zika virus transmission by Aedes aegypti." Proceedings of the National Academy of Sciences 116, no. 38 (2019): 19136–44. http://dx.doi.org/10.1073/pnas.1905617116.

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Zika virus (ZIKV) is an arthropod-borne flavivirus predominantly transmitted by Aedes aegypti mosquitoes and poses a global human health threat. All flaviviruses, including those that exclusively replicate in mosquitoes, produce a highly abundant, noncoding subgenomic flavivirus RNA (sfRNA) in infected cells, which implies an important function of sfRNA during mosquito infection. Currently, the role of sfRNA in flavivirus transmission by mosquitoes is not well understood. Here, we demonstrate that an sfRNA-deficient ZIKV (ZIKVΔSF1) replicates similar to wild-type ZIKV in mosquito cell culture

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16

AYADI, T., A. HAMMOUDA, A. POUX, T. BOULINIER, S. LECOLLINET, and S. SELMI. "Evidence of exposure of laughing doves (Spilopelia senegalensis) to West Nile and Usutu viruses in southern Tunisian oases." Epidemiology and Infection 145, no. 13 (2017): 2808–16. http://dx.doi.org/10.1017/s0950268817001789.

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SUMMARYIt has previously been suggested that southern Tunisian oases may be suitable areas for the circulation of flaviviruses. In order to anticipate and prevent possible epidemiological spread of flaviviruses in humans and domestic animals, the ecology of their transmission in the oasis system needs to be better understood. Thus, the aim of this study was to assess the seroprevalence of anti-flavivirus antibodies in the laughing dove (Spilopelia senegalensis), an abundant resident bird in Tunisian oases. Anti-flavivirus antibodies were detected in 17% of sampled doves. Ten per cent of the to

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17

Williams, Richard A. J., Hillary A. Criollo Valencia, Irene López Márquez, et al. "West Nile Virus Seroprevalence in Wild Birds and Equines in Madrid Province, Spain." Veterinary Sciences 11, no. 6 (2024): 259. http://dx.doi.org/10.3390/vetsci11060259.

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West Nile virus (WNV) is a re-emerging flavivirus, primarily circulating among avian hosts and mosquito vectors, causing periodic outbreaks in humans and horses, often leading to neuroinvasive disease and mortality. Spain has reported several outbreaks, most notably in 2020 with seventy-seven human cases and eight fatalities. WNV has been serologically detected in horses in the Community of Madrid, but to our knowledge, it has never been reported from wild birds in this region. To estimate the seroprevalence of WNV in wild birds and horses in the Community of Madrid, 159 wild birds at a wildli

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18

Reyes-Ruiz, José Manuel, Juan Fidel Osuna-Ramos, Luis Adrián De Jesús-González, et al. "The Regulation of Flavivirus Infection by Hijacking Exosome-Mediated Cell–Cell Communication: New Insights on Virus–Host Interactions." Viruses 12, no. 7 (2020): 765. http://dx.doi.org/10.3390/v12070765.

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The arthropod-borne flaviviruses are important human pathogens, and a deeper understanding of the virus–host cell interaction is required to identify cellular targets that can be used as therapeutic candidates. It is well reported that the flaviviruses hijack several cellular functions, such as exosome-mediated cell communication during infection, which is modulated by the delivery of the exosomal cargo of pro- or antiviral molecules to the receiving host cells. Therefore, to study the role of exosomes during flavivirus infections is essential, not only to understand its relevance in virus–hos

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Delfin-Riela, Triana, Martín Rossotti, Romina Alvez-Rosado, Carmen Leizagoyen, and Gualberto González-Sapienza. "Highly Sensitive Detection of Zika Virus Nonstructural Protein 1 in Serum Samples by a Two-Site Nanobody ELISA." Biomolecules 10, no. 12 (2020): 1652. http://dx.doi.org/10.3390/biom10121652.

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The Zika virus was introduced in Brazil in 2015 and, shortly after, spread all over the Americas. Nowadays, it remains present in more than 80 countries and represents a major threat due to some singularities among other flaviviruses. Due to its easy transmission, high percentage of silent cases, the severity of its associated complications, and the lack of prophylactic methods and effective treatments, it is essential to develop reliable and rapid diagnostic tests for early containment of the infection. Nonstructural protein 1 (NS1), a glycoprotein involved in all flavivirus infections, is se

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Peinado, Stephen A., Matthew T. Aliota, Bradley J. Blitvich, and Lyric C. Bartholomay. "Biology and Transmission Dynamics of Aedes flavivirus." Journal of Medical Entomology 59, no. 2 (2022): 659–66. http://dx.doi.org/10.1093/jme/tjab197.

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Abstract Aedes albopictus (Skuse) and Aedes aegypti (Linnaeus) (Diptera: Culicidae) mosquitoes transmit pathogenic arthropod-borne viruses, including dengue, chikungunya, and Zika viruses, with significant global health consequences. Both Ae. albopictus and Ae. aegypti also are susceptible to Aedes flavivirus (AEFV), an insect-specific flavivirus (ISF) first isolated in Japan from Ae. albopictus and Ae. flavopictus. ISFs infect only insect hosts and evidence suggests that they are maintained by vertical transmission. In some cases, ISFs interfere with pathogenic flavivirus infection, and may h

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Noden, Bruce H., Milka Musuuo, Larai Aku-Akai, Berta van der Colf, Israel Chipare, and Rob Wilkinson. "Risk assessment of flavivirus transmission in Namibia." Acta Tropica 137 (September 2014): 123–29. http://dx.doi.org/10.1016/j.actatropica.2014.05.010.

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22

Troupin, Andrea, Crystal Grippin, and Tonya M. Colpitts. "Flavivirus Pathogenesis in the Mosquito Transmission Vector." Current Clinical Microbiology Reports 4, no. 3 (2017): 115–23. http://dx.doi.org/10.1007/s40588-017-0066-6.

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Whelan, Jillian N., Nicholas A. Parenti, Joshua Hatterschide, et al. "Zika virus employs the host antiviral RNase L protein to support replication factory assembly." Proceedings of the National Academy of Sciences 118, no. 22 (2021): e2101713118. http://dx.doi.org/10.1073/pnas.2101713118.

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Infection with the flavivirus Zika virus (ZIKV) can result in tissue tropism, disease outcome, and route of transmission distinct from those of other flaviviruses; therefore, we aimed to identify host machinery that exclusively promotes the ZIKV replication cycle, which can inform on differences at the organismal level. We previously reported that deletion of the host antiviral ribonuclease L (RNase L) protein decreases ZIKV production. Canonical RNase L catalytic activity typically restricts viral infection, including that of the flavivirus dengue virus (DENV), suggesting an unconventional, p

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Bogdanic, Maja, Vladimir Savic, Ana Klobucar, et al. "The Re-Emergence of Neuroinvasive Flaviviruses in Croatia During the 2022 Transmission Season." Microorganisms 12, no. 11 (2024): 2210. http://dx.doi.org/10.3390/microorganisms12112210.

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(Re-)emerging arboviruses, such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), and Usutu virus (USUV), are continuously increasing in incidence. We analyzed the epidemiological characteristics of flavivirus infections in humans, sentinel animals, and mosquitoes detected in the 2022 transmission season in Croatia. From April to November 2022, 110 hospitalized patients with neuroinvasive diseases (NID) were tested for the presence of arboviruses. RT-qPCR was used to detect TBEV, WNV, and USUV RNA. An ELISA and virus neutralization tests were used for the detection of flavivirus

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Sakkas, Hercules, Petros Bozidis, Xenofon Giannakopoulos, Nikolaos Sofikitis, and Chrissanthy Papadopoulou. "An Update on Sexual Transmission of Zika Virus." Pathogens 7, no. 3 (2018): 66. http://dx.doi.org/10.3390/pathogens7030066.

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Zika virus (ZIKV) is a single-stranded RNA virus belonging to the arthropod-borne flaviviruses (arboviruses) which are mainly transmitted by blood-sucking mosquitoes of the genus Aedes. ZIKV infection has been known to be rather asymptomatic or presented as febrile self-limited disease; however, during the last decade the manifestation of ZIKV infection has been associated with a variety of neuroimmunological disorders including Guillain–Barré syndrome, microcephaly and other central nervous system abnormalities. More recently, there is accumulating evidence about sexual transmission of ZIKV,

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Porier, Danielle L., Sarah N. Wilson, Dawn I. Auguste, et al. "Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine." Vaccines 9, no. 10 (2021): 1142. http://dx.doi.org/10.3390/vaccines9101142.

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Vaccination remains critical for viral disease outbreak prevention and control, but conventional vaccine development typically involves trade-offs between safety and immunogenicity. We used a recently discovered insect-specific flavivirus as a vector in order to develop an exceptionally safe, flavivirus vaccine candidate with single-dose efficacy. To evaluate the safety and efficacy of this platform, we created a chimeric Zika virus (ZIKV) vaccine candidate, designated Aripo/Zika virus (ARPV/ZIKV). ZIKV has caused immense economic and public health impacts throughout the Americas and remains a

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Goërtz, G. P., J. J. Fros, P. Miesen, et al. "Non-coding RNA determines flavivirus transmission by mosquitoes." International Journal of Infectious Diseases 53 (December 2016): 162. http://dx.doi.org/10.1016/j.ijid.2016.11.395.

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Chevalier, Véronique, Maud Marsot, Sophie Molia, et al. "Serological Evidence of West Nile and Usutu Viruses Circulation in Domestic and Wild Birds in Wetlands of Mali and Madagascar in 2008." International Journal of Environmental Research and Public Health 17, no. 6 (2020): 1998. http://dx.doi.org/10.3390/ijerph17061998.

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The geographical distribution and impact on animal and human health of both West Nile and Usutu viruses, two flaviviruses of the Japanese encephalitis complex, have been increasing during the past two decades. Both viruses circulate in Europe and Africa within a natural cycle between wild birds and mosquitoes, mainly from the Culex genus. We retrospectively analyzed sera from domestic and wild birds sampled in 2008 in two wetlands, namely the Inner Niger Delta, Mali, and the Lake Alaotra area, Madagascar. Sera were first tested using a commercial ID Screen West Nile Competition Multi-species E

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Colmant, Agathe M. G., Jody Hobson-Peters, Teun A. P. Slijkerman, et al. "Insect-Specific Flavivirus Replication in Mammalian Cells Is Inhibited by Physiological Temperature and the Zinc-Finger Antiviral Protein." Viruses 13, no. 4 (2021): 573. http://dx.doi.org/10.3390/v13040573.

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The genus Flavivirus contains pathogenic vertebrate-infecting flaviviruses (VIFs) and insect-specific flaviviruses (ISF). ISF transmission to vertebrates is inhibited at multiple stages of the cellular infection cycle, via yet to be elucidated specific antiviral responses. The zinc-finger antiviral protein (ZAP) in vertebrate cells can bind CpG dinucleotides in viral RNA, limiting virus replication. Interestingly, the genomes of ISFs contain more CpG dinucleotides compared to VIFs. In this study, we investigated whether ZAP prevents two recently discovered lineage II ISFs, Binjari (BinJV) and

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Bournez, Laure, Gérald Umhang, Eva Faure, et al. "Exposure of Wild Ungulates to the Usutu and Tick-Borne Encephalitis Viruses in France in 2009–2014: Evidence of Undetected Flavivirus Circulation a Decade Ago." Viruses 12, no. 1 (2019): 10. http://dx.doi.org/10.3390/v12010010.

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Flaviviruses have become increasingly important pathogens in Europe over the past few decades. A better understanding of the spatiotemporal distribution of flaviviruses in France is needed to better define risk areas and to gain knowledge of the dynamics of virus transmission cycles. Serum samples from 1014 wild boar and 758 roe deer from 16 departments (administrative units) in France collected from 2009 to 2014 were screened for flavivirus antibodies using a competitive ELISA (cELISA) technique. Serum samples found to be positive or doubtful by cELISA were then tested for antibodies directed

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Chapagain, Subash, Prince Pal Singh, Khanh Le, David Safronetz, Heidi Wood, and Uladzimir Karniychuk. "Japanese encephalitis virus persists in the human reproductive epithelium and porcine reproductive tissues." PLOS Neglected Tropical Diseases 16, no. 7 (2022): e0010656. http://dx.doi.org/10.1371/journal.pntd.0010656.

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Japanese encephalitis virus (JEV) is the emerging and geographically expanding flavivirus and the major causative agent of encephalitis in humans in Asia. There are risks of JEV introduction into the Americas given a large population of amplifying hosts—pigs and wild boars, and insect vectors—Culex mosquitoes. There are emerging concerns about vector-free ways of flavivirus transmission, for example sexual and transplacental Zika virus transmissions, which may change flavivirus epidemiology and expand the geographical range to territories with no insect vectors. It is unknown whether JEV has t

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Nava, Jose Angel Regla, Ying-Ting Wang, Camila R. Fontes-Garfias, et al. "Zika virus evolution in the presence of dengue virus-elicited cross-reactive immunity." Journal of Immunology 204, no. 1_Supplement (2020): 249.7. http://dx.doi.org/10.4049/jimmunol.204.supp.249.7.

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Abstract Zika virus (ZIKV), belongs to Flavivirus, causes neurological disorders including Guillain Barré syndrome and fetal microcephaly, and is responsible for widespread epidemics in countries where other flaviviruses, such as dengue (DENV), and yellow fever viruses, are endemic. However, how the cross-reactive, pre-existing immunity impacts the evolution of flaviviruses is poorly understood. To mimic the natural transmission cycle of ZIKV between vertebrate (human) hosts with pre-existing flavivirus immunity and invertebrate hosts (mosquito), ZIKV was subjected to 10 alternating cycles of

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Zepeda, Omar, Daniel O. Espinoza, Evelin Martinez, et al. "Antibody Immunity to Zika Virus among Young Children in a Flavivirus-Endemic Area in Nicaragua." Viruses 15, no. 3 (2023): 796. http://dx.doi.org/10.3390/v15030796.

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Objective: To understand the dynamics of Zika virus (ZIKV)-specific antibody immunity in children born to mothers in a flavivirus-endemic region during and after the emergence of ZIKV in the Americas. Methods: We performed serologic testing for ZIKV cross-reactive and type-specific IgG in two longitudinal cohorts, which enrolled pregnant women and their children (PW1 and PW2) after the beginning of the ZIKV epidemic in Nicaragua. Quarterly samples from children over their first two years of life and maternal blood samples at birth and at the end of the two-year follow-up period were studied. R

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Nguyen-Tien, Thang, Anh Ngoc Bui, Jiaxin Ling, et al. "The Distribution and Composition of Vector Abundance in Hanoi City, Vietnam: Association with Livestock Keeping and Flavivirus Detection." Viruses 13, no. 11 (2021): 2291. http://dx.doi.org/10.3390/v13112291.

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Background: Dengue virus and Japanese encephalitis virus are two common flaviviruses that are spread widely by Aedes and Culex mosquitoes. Livestock keeping is vital for cities; however, it can pose the risk of increasing the mosquito population. Our study explored how livestock keeping in and around a large city is associated with the presence of mosquitoes and the risk of them spreading flaviviruses. Methods: An entomological study was conducted in 6 districts with 233 households with livestock, and 280 households without livestock, in Hanoi city. BG-Sentinel traps and CDC light traps were u

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Kushwaha, Nikhal, Vipin Kesharwani, and Pankaj Kumar Jaiswal. "A GLOBAL CONCERN ON ZIKA VIRUS: TRANSMISSION, DIAGNOSIS, PREVENTION, AND TREATMENT." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 136–40. http://dx.doi.org/10.22270/jddt.v8i5.1972.

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Zika virus is a mosquito-transmitted flavivirus belongs to family Flaviviridae which becomes the focus of an ongoing pandemic and public health emergency all around the world. Zika virus has two lineages African and Asian. Mosquito-borne flavivirus is thought to replicate initially in dendritic cell and then spread to lymph nodes and then to the bloodstream. Zika virus was initially recognized in Uganda in 1947 in Monkeys through a method that observed yellow fever. It was later distinguished in people in 1952 in Uganda and the United Republic of Tanzania. The explosions of the zika virus dise

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Shivaprasad, Shwetha, and Peter Sarnow. "Cross-species microRNA transmission modulates flavivirus growth in mosquitoes." Trends in Parasitology 38, no. 5 (2022): 349–50. http://dx.doi.org/10.1016/j.pt.2022.02.007.

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Vanegas, Hernan, Fredman González, Yaoska Reyes, et al. "Zika RNA and Flavivirus-Like Antigens in the Sperm Cells of Symptomatic and Asymptomatic Subjects." Viruses 13, no. 2 (2021): 152. http://dx.doi.org/10.3390/v13020152.

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Zika virus (ZIKV) RNA has been found to remain in human semen for up to one year after infection, but the presence of Flavivirus antigens in the different compartments of semen has been largely unexplored. Following the introduction of ZIKV in Nicaragua (2016), a prospective study of patients with clinical symptoms consistent with ZIKV was conducted in León to investigate virus shedding in different fluids. ZIKV infection was confirmed in 16 male subjects (≥18 years of age) by RT-qPCR in either blood, saliva or urine. Of these, three provided semen samples at 7, 14, 21, 28, 60 and 180 days pos

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38

Ogola, Edwin O., Armanda D. S. Bastos, Gilbert Rotich, et al. "Analyses of Mosquito Species Composition, Blood-Feeding Habits and Infection with Insect-Specific Flaviviruses in Two Arid, Pastoralist-Dominated Counties in Kenya." Pathogens 12, no. 7 (2023): 967. http://dx.doi.org/10.3390/pathogens12070967.

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Insect-specific flaviviruses (ISFs), although not known to be pathogenic to humans and animals, can modulate the transmission of arboviruses by mosquitoes. In this study, we screened 6665 host-seeking, gravid and blood-fed mosquitoes for infection with flaviviruses and assessed the vertebrate hosts of the blood-fed mosquitoes sampled in Baringo and Kajiado counties; both dryland ecosystem counties in the Kenyan Rift Valley. Sequence fragments of two ISFs were detected. Cuacua virus (CuCuV) was found in three blood-fed Mansonia (Ma.) africana. The genome was sequenced by next-generation sequenc

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39

Roldán, Julieta S., Alejandro Cassola, and Daniela S. Castillo. "Development of a novel NS1 competitive enzyme-linked immunosorbent assay for the early detection of Zika virus infection." PLOS ONE 16, no. 8 (2021): e0256220. http://dx.doi.org/10.1371/journal.pone.0256220.

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Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat after the 2015 outbreak in the Americas, where devastating congenital defects were documented. There are currently no vaccines to prevent ZIKV infections nor commercially available clinical diagnostic tests demonstrated to identify ZIKV without cross-reactive interference of related flaviviruses. Early diagnosis is critical when treating symptomatic patients and in preventing ZIKV transmission. In this context, the development of sensitive and accurate diagnostic methods are urgently needed for the detection of ZIKV a

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40

Abundes-Gallegos, Judith, Monica Salas-Rojas, Guillermo Galvez-Romero, et al. "Detection of Dengue Virus in Bat Flies (Diptera: Streblidae) of Common Vampire Bats, Desmodus rotundus, in Progreso, Hidalgo, Mexico." Vector-Borne and Zoonotic Diseases 18, no. 1 (2018): 70–73. https://doi.org/10.5281/zenodo.13491118.

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(Uploaded by Plazi for the Bat Literature Project) Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectopar

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41

Abundes-Gallegos, Judith, Monica Salas-Rojas, Guillermo Galvez-Romero, et al. "Detection of Dengue Virus in Bat Flies (Diptera: Streblidae) of Common Vampire Bats, Desmodus rotundus, in Progreso, Hidalgo, Mexico." Vector-Borne and Zoonotic Diseases 18, no. 1 (2018): 70–73. https://doi.org/10.5281/zenodo.13491118.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectopar

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42

Abundes-Gallegos, Judith, Monica Salas-Rojas, Guillermo Galvez-Romero, et al. "Detection of Dengue Virus in Bat Flies (Diptera: Streblidae) of Common Vampire Bats, Desmodus rotundus, in Progreso, Hidalgo, Mexico." Vector-Borne and Zoonotic Diseases 18, no. 1 (2018): 70–73. https://doi.org/10.5281/zenodo.13491118.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectopar

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43

Abundes-Gallegos, Judith, Monica Salas-Rojas, Guillermo Galvez-Romero, et al. "Detection of Dengue Virus in Bat Flies (Diptera: Streblidae) of Common Vampire Bats, Desmodus rotundus, in Progreso, Hidalgo, Mexico." Vector-Borne and Zoonotic Diseases 18, no. 1 (2018): 70–73. https://doi.org/10.5281/zenodo.13491118.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectopar

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44

Masmejan, Sophie, Didier Musso, Manon Vouga, et al. "Zika Virus." Pathogens 9, no. 11 (2020): 898. http://dx.doi.org/10.3390/pathogens9110898.

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Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the Aedes mosquitoes and humans. To date, outbreaks of ZIKV have occurred in Africa, Southeast Asia, the Pacific islands, the Americas, and the Caribbean. Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology

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Samuel, Glady Hazitha, Michael R. Wiley, Atif Badawi, Zach N. Adelman, and Kevin M. Myles. "Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA." Proceedings of the National Academy of Sciences 113, no. 48 (2016): 13863–68. http://dx.doi.org/10.1073/pnas.1600544113.

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Mosquito-borne flaviviruses, including yellow fever virus (YFV), Zika virus (ZIKV), and West Nile virus (WNV), profoundly affect human health. The successful transmission of these viruses to a human host depends on the pathogen’s ability to overcome a potentially sterilizing immune response in the vector mosquito. Similar to other invertebrate animals and plants, the mosquito’s RNA silencing pathway comprises its primary antiviral defense. Although a diverse range of plant and insect viruses has been found to encode suppressors of RNA silencing, the mechanisms by which flaviviruses antagonize

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Grubaugh, Nathan D., Claudia Rückert, Philip M. Armstrong, et al. "Transmission bottlenecks and RNAi collectively influence tick-borne flavivirus evolution." Virus Evolution 2, no. 2 (2016): vew033. http://dx.doi.org/10.1093/ve/vew033.

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47

Wahaab, Abdul, Bahar E. Mustafa, Muddassar Hameed, et al. "An Overview of Zika Virus and Zika Virus Induced Neuropathies." International Journal of Molecular Sciences 26, no. 1 (2024): 47. https://doi.org/10.3390/ijms26010047.

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Flaviviruses pose a major public health concern across the globe. Among them, Zika virus (ZIKV) is an emerging and reemerging arthropod-borne flavivirus that has become a major international public health problem following multiple large outbreaks over the past two decades. The majority of infections caused by ZIKV exhibit mild symptoms. However, the virus has been found to be associated with a variety of congenital neural abnormalities, including microcephaly in children and Guillain–Barre syndrome in adults. The exact prediction of the potential of ZIKV transmission is still enigmatic and un

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Tan, Terence T. T., Raghavan Bhuvanakantham, Jun Li, Josephine Howe, and Mah-Lee Ng. "Tyrosine 78 of premembrane protein is essential for assembly of West Nile virus." Journal of General Virology 90, no. 5 (2009): 1081–92. http://dx.doi.org/10.1099/vir.0.007872-0.

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Flavivirus premembrane (prM) protein plays an important role in conformational folding of the envelope (E) protein and protects it against premature fusion in acidic vesicles of the Golgi network. Currently, molecular determinants on the prM protein ectodomain which mediate critical steps during the flavivirus assembly process are poorly characterized. In this study, bioinformatics analysis and alanine scanning mutagenesis showed that the amino acid triplet valine 76, tyrosine 78 and glycine 79 is absolutely conserved among flavivirus prM ectodomains. Triple mutations engineered at these resid

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Bekal, Sadia, Leslie L. Domier, Biruk Gonfa, Nancy K. McCoppin, Kris N. Lambert, and Kaustubh Bhalerao. "A novel flavivirus in the soybean cyst nematode." Journal of General Virology 95, no. 6 (2014): 1272–80. http://dx.doi.org/10.1099/vir.0.060889-0.

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Heterodera glycines, the soybean cyst nematode (SCN), is a subterranean root pathogen that causes the most damaging disease of soybean in the USA. A novel nematode virus genome, soybean cyst nematode virus 5 (SbCNV-5), was identified in RNA sequencing data from SCN eggs and second-stage juveniles. The SbCNV-5 RNA-dependent RNA polymerase and RNA helicase domains had homology to pestiviruses in the family Flaviviridae, suggesting that SbCNV-5 is a positive-polarity ssRNA virus. SbCNV-5 RNA was present in all nematode developmental stages, indicating a transovarial mode of transmission, but is a

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Li, Xuesong, Ying Shi, Qinfang Liu, et al. "Airborne Transmission of a Novel Tembusu Virus in Ducks." Journal of Clinical Microbiology 53, no. 8 (2015): 2734–36. http://dx.doi.org/10.1128/jcm.00770-15.

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The routes of transmission of a newly emerged Tembusu virus (TMUV, Flavivirus ) in ducks in China remain unclear. Our epidemiological data show that TMUV is spread in winter, when mosquitos are inactive, which suggests that nonvector transmission routes are involved in the spread of TMUV. Furthermore, in vivo studies indicate that TMUV can be transmitted efficiently among ducks by both direct contact and aerosol transmission. This finding has important implications for the control of infection with this novel TMUV in the field.

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