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Journal articles on the topic 'Flaviviruses'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Heinz, Franz X., and Karin Stiasny. "Flaviviruses and flavivirus vaccines." Vaccine 30, no. 29 (June 2012): 4301–6. http://dx.doi.org/10.1016/j.vaccine.2011.09.114.

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2

Huhtamo, Eili, Niina Putkuri, Satu Kurkela, Tytti Manni, Antti Vaheri, Olli Vapalahti, and Nathalie Y. Uzcátegui. "Characterization of a Novel Flavivirus from Mosquitoes in Northern Europe That Is Related to Mosquito-Borne Flaviviruses of the Tropics." Journal of Virology 83, no. 18 (July 1, 2009): 9532–40. http://dx.doi.org/10.1128/jvi.00529-09.

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ABSTRACT A novel flavivirus was isolated from mosquitoes in Finland, representing the first mosquito-borne flavivirus from Northern Europe. The isolate, designated Lammi virus (LAMV), was antigenically cross-reactive with other flaviviruses and exhibited typical flavivirus morphology as determined by electron microscopy. The genomic sequence of LAMV was highly divergent from the recognized flaviviruses, and yet the polyprotein properties resembled those of mosquito-borne flaviviruses. Phylogenetic analysis of the complete coding sequence showed that LAMV represented a distinct lineage related

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3

Alkan, Cigdem, Sonia Zapata, Laurence Bichaud, Grégory Moureau, Philippe Lemey, Andrew E. Firth, Tamara S. Gritsun, et al. "Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus." Journal of Virology 89, no. 23 (September 9, 2015): 11773–85. http://dx.doi.org/10.1128/jvi.01543-15.

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ABSTRACTA new flavivirus, Ecuador Paraiso Escondido virus (EPEV), named after the village where it was discovered, was isolated from sand flies (Psathyromyia abonnenci, formerlyLutzomyia abonnenci) that are unique to the New World. This represents the first sand fly-borne flavivirus identified in the New World. EPEV exhibited a typical flavivirus genome organization. Nevertheless, the maximum pairwise amino acid sequence identity with currently recognized flaviviruses was 52.8%. Phylogenetic analysis of the complete coding sequence showed that EPEV represents a distinct clade which diverged fr

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4

Dong, Hao-Long, Mei-Juan He, Qing-Yang Wang, Jia-Zhen Cui, Zhi-Li Chen, Xiang-Hua Xiong, Lian-Cheng Zhang, et al. "Rapid Generation of Recombinant Flaviviruses Using Circular Polymerase Extension Reaction." Vaccines 11, no. 7 (July 17, 2023): 1250. http://dx.doi.org/10.3390/vaccines11071250.

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The genus Flavivirus is a group of arthropod-borne single-stranded RNA viruses, which includes important human and animal pathogens such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), Dengue virus (DENV), yellow fever virus (YFV), West Nile virus (WNV), and Tick-borne encephalitis virus (TBEV). Reverse genetics has been a useful tool for understanding biological properties and the pathogenesis of flaviviruses. However, the conventional construction of full-length infectious clones for flavivirus is time-consuming and difficult due to the toxicity of the flavivirus genome to E. coli.

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5

Cook, Shelley, Gregory Moureau, Andrew Kitchen, Ernest A. Gould, Xavier de Lamballerie, Edward C. Holmes, and Ralph E. Harbach. "Molecular evolution of the insect-specific flaviviruses." Journal of General Virology 93, no. 2 (February 1, 2012): 223–34. http://dx.doi.org/10.1099/vir.0.036525-0.

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There has been an explosion in the discovery of ‘insect-specific’ flaviviruses and/or their related sequences in natural mosquito populations. Herein we review all ‘insect-specific’ flavivirus sequences currently available and conduct phylogenetic analyses of both the ‘insect-specific’ flaviviruses and available sequences of the entire genus Flavivirus. We show that there is no statistical support for virus–mosquito co-divergence, suggesting that the ‘insect-specific’ flaviviruses may have undergone multiple introductions with frequent host switching. We discuss potential implications for the

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6

Gibbs, Tristan, and David J. Speers. "Neurological disease caused by flavivirus infections." Microbiology Australia 39, no. 2 (2018): 99. http://dx.doi.org/10.1071/ma18029.

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The Flavivirus genus contains dozens of species with varying geographical distributions. Most flavivirus infections in humans are asymptomatic or manifest as a non-specific febrile illness, sometimes accompanied by rash or arthralgia. Certain species are more commonly associated with neurological disease and may be termed neurotropic flaviviruses. Several flaviviruses endemic to Australia and our near northern neighbours are neurotropic, such as Murray Valley encephalitis virus, West Nile (Kunjin) virus and Japanese encephalitis virus. Flavivirus neurological disease ranges from self-limiting

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7

Liao, Ching-Len, Yi-Ling Lin, Bi-Ching Wu, Chang-Huei Tsao, Mei-Chuan Wang, Chiu-I. Liu, Yue-Ling Huang, Jui-Hui Chen, Jia-Pey Wang, and Li-Kuang Chen. "Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation." Journal of Virology 75, no. 17 (September 1, 2001): 7828–39. http://dx.doi.org/10.1128/jvi.75.17.7828-7839.2001.

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ABSTRACT Flaviviruses comprise a positive-sense RNA genome that replicates exclusively in the cytoplasm of infected cells. Whether flaviviruses require an activated nuclear factor(s) to complete their life cycle and trigger apoptosis in infected cells remains elusive. Flavivirus infections quickly activate nuclear factor kappa B (NF-κB), and salicylates have been shown to inhibit NF-κB activation. In this study, we investigated whether salicylates suppress flavivirus replication and virus-induced apoptosis in cultured cells. In a dose-dependent inhibition, we found salicylates within a range o

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8

Hou, Baohua, Hui Chen, Na Gao, and Jing An. "Cross-Reactive Immunity among Five Medically Important Mosquito-Borne Flaviviruses Related to Human Diseases." Viruses 14, no. 6 (June 2, 2022): 1213. http://dx.doi.org/10.3390/v14061213.

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Flaviviruses cause a spectrum of potentially severe diseases. Most flaviviruses are transmitted by mosquitoes or ticks and are widely distributed all over the world. Among them, several mosquito-borne flaviviruses are co-epidemic, and the similarity of their antigenicity creates abundant cross-reactive immune responses which complicate their prevention and control. At present, only effective vaccines against yellow fever and Japanese encephalitis have been used clinically, while the optimal vaccines against other flavivirus diseases are still under development. The antibody-dependent enhanceme

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9

Guarido, Milehna M., Kamini Govender, Megan A. Riddin, Maarten Schrama, Erin E. Gorsich, Basil D. Brooke, Antonio Paulo Gouveia Almeida, and Marietjie Venter. "Detection of Insect-Specific Flaviviruses in Mosquitoes (Diptera: Culicidae) in Northeastern Regions of South Africa." Viruses 13, no. 11 (October 25, 2021): 2148. http://dx.doi.org/10.3390/v13112148.

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Mosquitoes in the Aedes and Culex genera are considered the main vectors of pathogenic flaviviruses worldwide. Entomological surveillance using universal flavivirus sets of primers in mosquitoes can detect not only pathogenic viruses but also insect-specific ones. It is hypothesized that insect-specific flaviviruses, which naturally infect these mosquitoes, may influence their vector competence for zoonotic arboviruses. Here, entomological surveillance was performed between January 2014 and May 2018 in five different provinces in the northeastern parts of South Africa, with the aim of identify

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10

Habarugira, Gervais, Jasmin Moran, Jessica J. Harrison, Sally R. Isberg, Jody Hobson-Peters, Roy A. Hall, and Helle Bielefeldt-Ohmann. "Evidence of Infection with Zoonotic Mosquito-Borne Flaviviruses in Saltwater Crocodiles (Crocodylus porosus) in Northern Australia." Viruses 14, no. 5 (May 21, 2022): 1106. http://dx.doi.org/10.3390/v14051106.

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The risk of flavivirus infections among the crocodilian species was not recognised until West Nile virus (WNV) was introduced into the Americas. The first outbreaks caused death and substantial economic losses in the alligator farming industry. Several other WNV disease episodes have been reported in crocodilians in other parts of the world, including Australia and Africa. Considering that WNV shares vectors with other flaviviruses, crocodilians are highly likely to also be exposed to flaviviruses other than WNV. A serological survey for flaviviral infections was conducted on saltwater crocodi

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11

Charlier, Nathalie, Pieter Leyssen, Cornelis W. A. Pleij, Philippe Lemey, Frédérique Billoir, Kristel Van Laethem, Anne-Mieke Vandamme, Erik De Clercq, Xavier de Lamballerie, and Johan Neyts. "Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3′ untranslated region of flaviviruses with no known vector." Journal of General Virology 83, no. 8 (August 1, 2002): 1875–85. http://dx.doi.org/10.1099/0022-1317-83-8-1875.

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Montana Myotis leukoencephalitis virus (MMLV), a virus isolated from bats, causes an encephalitis in small rodents reminiscent of flavivirus encephalitis in humans. The complete MMLV genome is 10690 nucleotides long and encodes a putative polyprotein of 3374 amino acids. The virus contains the same conserved motifs in genes that are believed to be interesting antiviral targets (NTPase/helicase, serine protease and RNA-dependent RNA polymerase) as flaviviruses of clinical importance. Phylogenetic analysis of the entire coding region has confirmed the classification of MMLV in the clade of the f

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12

Calzolari, Mattia, Líbia Zé-Zé, Daniel Růžek, Ana Vázquez, Claire Jeffries, Francesco Defilippo, Hugo Costa Osório, et al. "Detection of mosquito-only flaviviruses in Europe." Journal of General Virology 93, no. 6 (June 1, 2012): 1215–25. http://dx.doi.org/10.1099/vir.0.040485-0.

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The genus Flavivirus, family Flaviviridae, includes a number of important arthropod-transmitted human pathogens such as dengue viruses, West Nile virus, Japanese encephalitis virus and yellow fever virus. In addition, the genus includes flaviviruses without a known vertebrate reservoir, which have been detected only in insects, particularly in mosquitoes, such as cell fusing agent virus, Kamiti River virus, Culex flavivirus, Aedes flavivirus, Quang Binh virus, Nakiwogo virus and Calbertado virus. Reports of the detection of these viruses with no recognized pathogenic role in humans are increas

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13

Junglen, Sandra, Anne Kopp, Andreas Kurth, Georg Pauli, Heinz Ellerbrok, and Fabian H. Leendertz. "A New Flavivirus and a New Vector: Characterization of a Novel Flavivirus Isolated from Uranotaenia Mosquitoes from a Tropical Rain Forest." Journal of Virology 83, no. 9 (February 18, 2009): 4462–68. http://dx.doi.org/10.1128/jvi.00014-09.

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ABSTRACT A novel flavivirus was isolated from Uranotaenia mashonaensis, a mosquito genus not previously known to harbor flaviviruses. Mosquitoes were caught in the primary rain forest of the Taï National Park, Côte d'Ivoire. The novel virus, termed nounané virus (NOUV), seemed to grow only on C6/36 insect cells and not on vertebrate cells. Typical enveloped flavivirus-like particles of 60 to 65 nm in diameter were detected by electron microscopy in the cell culture supernatant of infected cells. The full genome was sequenced, and potential cleavage and glycosylation sites and cysteine resid

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14

Wahaab, Abdul, Bahar E. Mustafa, Muddassar Hameed, Nigel J. Stevenson, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Yafeng Qiu, and Zhiyong Ma. "Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review." Viruses 14, no. 1 (December 28, 2021): 44. http://dx.doi.org/10.3390/v14010044.

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Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored. The flavivirus NS2B-NS3 proteases are responsible for the cleavage of the flavivirus polyprotein, which is necessary for productive viral infection and for causing clinical infections; therefore, they are a promising drug target for devising novel drugs against different flaviviruses. This review highlights the structural details of the NS2B-NS3 proteases of different flaviv

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15

Singh, Rekha, and Sharone Green. "Enhanced CD8+ T-cell immunity following sequential flavivirus vaccines (39.19)." Journal of Immunology 184, no. 1_Supplement (April 1, 2010): 39.19. http://dx.doi.org/10.4049/jimmunol.184.supp.39.19.

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Abstract Flaviviruses are arthropod-borne, RNA viruses of the Flaviviridae family. Flavivirus antigen-specific CD8+ T-cells are important in virus clearance. Primary exposure to a virus causes priming of CD8+ T-cells by virus-derived immunodominant peptides, leading to clonal differentiation and proliferation of effector cells followed by contraction and memory generation. ChimeriVax™ Flavivirus vaccines contain the nonstructural genes of the yellow fever (YF) vaccine and the prM and E genes of heterologous flaviviruses such as Japanese encephalitis (JE) and West Nile (WN) viruses. These chime

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16

Castilho, Leda R., Nathalia R. Mattos, Wallace S. Abreu, and Melissa L. E. Gutarra. "Virus-Like Particles (VLPs) as Important Tools for Flavivirus Vaccine Development." Biologics 2, no. 4 (October 31, 2022): 226–42. http://dx.doi.org/10.3390/biologics2040018.

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Flaviviruses, such as dengue, zika, yellow fever, West Nile, and Japanese encephalitis virus, are RNA viruses belonging to the Flaviviridae family (genus Flavivirus). They represent an important global health concern, since most areas of the world are endemic for at least one of these viruses. Although vaccines for five flaviviruses currently exist, there is a need for new vaccines to protect from established, emerging, and reemerging flaviviruses. Yellow fever vaccine shortages experienced in the last decade, combined with the risk of YFV spread to Asia and the restrictions of vaccine adminis

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17

Zhang, Naru, Chaoqun Li, Shibo Jiang, and Lanying Du. "Recent Advances in the Development of Virus-Like Particle-Based Flavivirus Vaccines." Vaccines 8, no. 3 (August 27, 2020): 481. http://dx.doi.org/10.3390/vaccines8030481.

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Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have expanded in geographic distribution and refocused international attention in recent years. Vaccination is one of the most effective public health strategies for combating flavivirus infections. In this review, we summarized virus-like particle (VLP)-based vaccines against the above four mentioned flaviviruses. Potential strategies to improve the efficacy of VLP-based flavivirus vaccines were also illustrated. The applic

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18

Qiu, Yang, Yan-Peng Xu, Miao Wang, Meng Miao, Hui Zhou, Jiuyue Xu, Jing Kong, et al. "Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes." Science Advances 6, no. 6 (February 2020): eaax7989. http://dx.doi.org/10.1126/sciadv.aax7989.

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Mosquito-borne flaviviruses infect both mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flaviviruses induce and antagonize RNAi-mediated antiviral immunity in mammals remains unknown. We show that the nonstructural protein NS2A of dengue virus-2 (DENV2) act as a viral suppressor of RNAi (VSR). When NS2A-mediated RNAi suppression was disabled, the resulting mutant DENV2 induced Dicer-dependent production of abundant DENV2-derived siRNAs in differentiated mammalian cells. VSR-disabled DENV2 showed sever

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Reis, Vinicius Pinho dos, Markus Keller, Katja Schmidt, Rainer Günter Ulrich та Martin Hermann Groschup. "αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells". Viruses 14, № 1 (23 грудня 2021): 18. http://dx.doi.org/10.3390/v14010018.

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The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe. Integrins, a family of heterodimeric transmembrane molecules expressed in all nucleated cells mediate critical functions of cell physiology and cell cycle. Integrins were previously postulated to be involved in flavivirus entry and to modulate flavivirus replication efficiency. In the present study, mouse embryonic fibroblasts (MEF), lacking the expression of αVβ3 integrin (MEF-αVβ3−/−), were infected with four different flaviviruses, namely

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Gomes da Silva, Priscilla, José Augusto Seixas dos Reis, Marcio Nogueira Rodrigues, Quézia da Silva Ardaya, and João Rodrigo Mesquita. "Serological Cross-Reactivity in Zoonotic Flaviviral Infections of Medical Importance." Antibodies 12, no. 1 (February 24, 2023): 18. http://dx.doi.org/10.3390/antib12010018.

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Flaviviruses are enveloped RNA viruses from the family Flaviviridae that comprise many important human pathogenic arboviruses such as Yellow Fever, Dengue, and Zika viruses. Because they belong to the same genus, these viruses show sequence and structural homology among them, which results in serological cross-reactivity. Upon infection, the immune system produces both species-specific and cross-reactive antibodies, and depending on the virus, in a successive flavivirus infection, cross-reactive antibodies either enhance protection or exacerbate the disease—the latter usually due to antibody-d

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Qian, Xijing, and Zhongtian Qi. "Mosquito-Borne Flaviviruses and Current Therapeutic Advances." Viruses 14, no. 6 (June 5, 2022): 1226. http://dx.doi.org/10.3390/v14061226.

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Mosquito-borne flavivirus infections affect approximately 400 million people worldwide each year and are global threats to public health. The common diseases caused by such flaviviruses include West Nile, yellow fever, dengue, Zika infection and Japanese encephalitis, which may result in severe symptoms and disorders of multiple organs or even fatal outcomes. Till now, no specific antiviral agents are commercially available for the treatment of the diseases. Numerous strategies have been adopted to develop novel and promising inhibitors against mosquito-borne flaviviruses, including drugs targ

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22

Kenney, Joan L., Owen D. Solberg, Stanley A. Langevin, and Aaron C. Brault. "Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses." Journal of General Virology 95, no. 12 (December 1, 2014): 2796–808. http://dx.doi.org/10.1099/vir.0.068031-0.

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In the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. We recently described the isolation of a novel flavivirus (tentatively designated ‘Nhumirim virus’; NHUV) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. We characterized the in vitro growth potential and 3′ untranslated region (UTR) sequence homology with alternative flaviviruses, and evalu

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23

Berneck, Beatrice Sarah, Alexandra Rockstroh, Jasmin Fertey, Thomas Grunwald, and Sebastian Ulbert. "A Recombinant Zika Virus Envelope Protein with Mutations in the Conserved Fusion Loop Leads to Reduced Antibody Cross-Reactivity upon Vaccination." Vaccines 8, no. 4 (October 13, 2020): 603. http://dx.doi.org/10.3390/vaccines8040603.

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Zika virus (ZIKV) is a zoonotic, human pathogenic, and mosquito-borne flavivirus. Its distribution is rapidly growing worldwide. Several attempts to develop vaccines for ZIKV are currently ongoing. Central to most vaccination approaches against flavivirus infections is the envelope (E) protein, which is the major target of neutralizing antibodies. Insect-cell derived, recombinantly expressed variants of E from the flaviviruses West Nile and Dengue virus have entered clinical trials in humans. Also for ZIKV, these antigens are promising vaccine candidates. Due to the structural similarity of fl

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Vicenzi, Elisa, Isabel Pagani, Silvia Ghezzi, Sarah L. Taylor, Timothy R. Rudd, Marcelo A. Lima, Mark A. Skidmore, and Edwin A. Yates. "Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection." Biochemical Society Transactions 46, no. 3 (April 20, 2018): 609–17. http://dx.doi.org/10.1042/bst20170399.

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Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, cells and tissues. Flaviviruses are largely transmitted by mosquito bites and humans are usually incidental, dead-end hosts, with the notable exceptions of YFV, DENV and ZIKV. Infection by flaviviruses elicits cellular responses including cell death via necrosis, pyroptosis (involving inflammation) or apoptosis (which avoids inflammation). Flavivirus

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Howard-Jones, Annaleise R., David Pham, Rebecca Sparks, Susan Maddocks, Dominic E. Dwyer, Jen Kok, and Kerri Basile. "Arthropod-Borne Flaviviruses in Pregnancy." Microorganisms 11, no. 2 (February 8, 2023): 433. http://dx.doi.org/10.3390/microorganisms11020433.

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Flaviviruses are a diverse group of enveloped RNA viruses that cause significant clinical manifestations in the pregnancy and postpartum periods. This review highlights the epidemiology, pathophysiology, clinical features, diagnosis, and prevention of the key arthropod-borne flaviviruses of concern in pregnancy and the neonatal period—Zika, Dengue, Japanese encephalitis, West Nile, and Yellow fever viruses. Increased disease severity during pregnancy, risk of congenital malformations, and manifestations of postnatal infection vary widely amongst this virus family and may be quite marked. Labor

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AYADI, T., A. HAMMOUDA, A. POUX, T. BOULINIER, S. LECOLLINET, and S. SELMI. "Evidence of exposure of laughing doves (Spilopelia senegalensis) to West Nile and Usutu viruses in southern Tunisian oases." Epidemiology and Infection 145, no. 13 (August 14, 2017): 2808–16. http://dx.doi.org/10.1017/s0950268817001789.

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SUMMARYIt has previously been suggested that southern Tunisian oases may be suitable areas for the circulation of flaviviruses. In order to anticipate and prevent possible epidemiological spread of flaviviruses in humans and domestic animals, the ecology of their transmission in the oasis system needs to be better understood. Thus, the aim of this study was to assess the seroprevalence of anti-flavivirus antibodies in the laughing dove (Spilopelia senegalensis), an abundant resident bird in Tunisian oases. Anti-flavivirus antibodies were detected in 17% of sampled doves. Ten per cent of the to

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Zheng, Xiaoyan, and Ran Wang. "Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice." Journal of Tropical Medicine 2022 (June 1, 2022): 1–12. http://dx.doi.org/10.1155/2022/4663735.

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Objective. Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are several important flaviviruses, and infections caused by these flaviviruses remain worldwide health problems. Different flaviviruses exhibit different biological characteristics and pathogenicity. Metabolomics is an emerging research perspective to uncover and observe the pathogenesis of certain infections. Methods. To improve the understanding of the specific metabolic changes that occur during infection with different flaviviruses, considering the principle of noninvasive sampling, this article descr

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Dowd, Kimberly A., and Theodore C. Pierson. "The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity." Annual Review of Virology 5, no. 1 (September 29, 2018): 185–207. http://dx.doi.org/10.1146/annurev-virology-092917-043300.

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Flaviviruses are arthropod-borne RNA viruses that are a significant threat to global health due to their widespread distribution, ability to cause severe disease in humans, and capacity for explosive spread following introduction into new regions. Members of this genus include dengue, tick-borne encephalitis, yellow fever, and Zika viruses. Vaccination has been a highly successful means to control flaviviruses, and neutralizing antibodies are an important component of a protective immune response. High-resolution structures of flavivirus structural proteins and virions, alone and in complex wi

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Shanshin, Daniil V., Sophia S. Borisevich, Alexander A. Bondar, Yuri B. Porozov, Elena A. Rukhlova, Elena V. Protopopova, Nikita D. Ushkalenko, et al. "Can Modern Molecular Modeling Methods Help Find the Area of Potential Vulnerability of Flaviviruses?" International Journal of Molecular Sciences 23, no. 14 (July 13, 2022): 7721. http://dx.doi.org/10.3390/ijms23147721.

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Flaviviruses are single-stranded RNA viruses that have emerged in recent decades and infect up to 400 million people annually, causing a variety of potentially severe pathophysiological processes including hepatitis, encephalitis, hemorrhagic fever, tissues and capillaries damage. The Flaviviridae family is represented by four genera comprising 89 known virus species. There are no effective therapies available against many pathogenic flaviviruses. One of the promising strategies for flavivirus infections prevention and therapy is the use of neutralizing antibodies (NAb) that can disable the vi

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Kuhn, Richard J., Alan D. T. Barrett, Aravinda M. Desilva, Eva Harris, Laura D. Kramer, Ruth R. Montgomery, Theodore C. Pierson, Alessandro Sette, and Michael S. Diamond. "A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures." Journal of Infectious Diseases 228, Supplement_6 (October 15, 2023): S398—S413. http://dx.doi.org/10.1093/infdis/jiad193.

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Abstract Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective. While vaccines against some medically important flaviviruses are available

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Yezli, Saber, Muhammad Yasir, Yara Yassin, Afnan Almazrua, Tagreed Al-Subhi, Norah Othman, Abdiasiis Omar, et al. "Lack of Zika Virus and Other Recognized Flaviviruses among the Mosquito Vectors during and Post the Hajj Mass Gathering." International Journal of Environmental Research and Public Health 18, no. 12 (June 10, 2021): 6275. http://dx.doi.org/10.3390/ijerph18126275.

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Makkah city, Kingdom of Saudi Arabia (KSA), contains many of the world’s mosquito vectors of parasitic and arboviral disease and is the site of the Hajj mass gathering. As such there is a risk of exportation and globalization of vector-borne viruses, including the re-emerging Zika virus (ZIKV). There was international concern regarding the introduction of ZIKV to KSA and potential international spread of the virus following the 2016 Hajj which took place few days after the Rio summer Olympics at the height of the ZIKV pandemic. We aimed to detect flaviviruses, including ZIKV, circulating among

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Nazarenko, Alina S., Mikhail F. Vorovitch, Yulia K. Biryukova, Nikolay B. Pestov, Ekaterina A. Orlova, Nickolai A. Barlev, Nadezhda M. Kolyasnikova, and Aydar A. Ishmukhametov. "Flaviviruses in AntiTumor Therapy." Viruses 15, no. 10 (September 22, 2023): 1973. http://dx.doi.org/10.3390/v15101973.

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Oncolytic viruses offer a promising approach to tumor treatment. These viruses not only have a direct lytic effect on tumor cells but can also modify the tumor microenvironment and activate antitumor immunity. Due to their high pathogenicity, flaviviruses have often been overlooked as potential antitumor agents. However, with recent advancements in genetic engineering techniques, an extensive history with vaccine strains, and the development of new attenuated vaccine strains, there has been a renewed interest in the Flavivirus genus. Flaviviruses can be genetically modified to express transgen

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JAEGER, A., S. LECOLLINET, C. BECK, M. BASTIEN, M. LE CORRE, K. DELLAGI, H. PASCALIS, T. BOULINIER, and C. LEBARBENCHON. "Serological evidence for the circulation of flaviviruses in seabird populations of the western Indian Ocean." Epidemiology and Infection 144, no. 3 (July 21, 2015): 652–60. http://dx.doi.org/10.1017/s0950268815001661.

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SUMMARYBirds play a central role in the epidemiology of several flaviviruses of concern for public and veterinary health. Seabirds represent the most abundant and widespread avifauna in the western Indian Ocean and may play an important role as host reservoirs and spreaders of arthropod-borne pathogens such as flaviviruses. We report the results of a serological investigation based on blood samples collected from nine seabird species from seven islands in the Indian Ocean. Using a commercial competitive enzyme-linked immunosorbent assay directed against the prototypic West Nile flavivirus, ant

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Petruccelli, Angela, Tiziana Zottola, Gianmarco Ferrara, Valentina Iovane, Cristina Di Russo, Ugo Pagnini, and Serena Montagnaro. "West Nile Virus and Related Flavivirus in European Wild Boar (Sus scrofa), Latium Region, Italy: A Retrospective Study." Animals 10, no. 3 (March 16, 2020): 494. http://dx.doi.org/10.3390/ani10030494.

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Background: A retrospective sero-survey for evidence of West Nile virus (WNV) infection in European wild boar (Sus scorfa) was conducted in the Latium region, Italy, on stored serum samples of the period November 2011 to January 2012. Methods: Sera were collected from 168 European wild boars and screened for antibodies to WNV and other Flaviviruses by competitive enzyme linked immunosorbent assay (cELISA). All sera positive for Flavivirus antibodies by cELISA were further examined by virus neutralization test (VNT). To test the presence of Flavivirus RNA in samples, an RT-PCR was performed usi

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Roy, Proyasha, Sumanta Dey, Ashesh Nandy, Subhash C. Basak, and Sukhen Das. "Base Distribution in Dengue Nucleotide Sequences Differs Significantly from Other Mosquito-Borne Human-Infecting Flavivirus Members." Current Computer-Aided Drug Design 15, no. 1 (December 14, 2018): 29–44. http://dx.doi.org/10.2174/1573409914666180731090005.

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Introduction: Among the mosquito-borne human-infecting flavivirus species that include Zika, West Nile, yellow fever, Japanese encephalitis and Dengue viruses, the Zika virus is found to be closest to Dengue virus, sharing the same clade in the Flavivirus phylogenetic tree. We consider these five flaviviruses and on closer examination in our analyses, the nucleotide sequences of the Dengue viral genes (envelope and NS5) and genomes are seen to be quite widely different from the other four flaviviruses. We consider the extent of this distinction and determine the advantage and/or disadvantage s

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Stefanik, Michal, James J. Valdes, Fortunatus C. Ezebuo, Jan Haviernik, Ikemefuna C. Uzochukwu, Martina Fojtikova, Jiri Salat, Ludek Eyer, and Daniel Ruzek. "FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells." Microorganisms 8, no. 4 (April 20, 2020): 599. http://dx.doi.org/10.3390/microorganisms8040599.

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Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S. Food and Drug Administration-approved antiviral drugs for their interaction with Zika virus proteins. Twelve hit drugs were identified by the docking experiments and tested in cell-based antiviral assay systems. Efavirenz, tipranavir, and dasabuvir at micromolar concentrations were identified to inhibit all VBFs tested; i.e., two representatives of mosquito-borne flaviviruses (Zika and We

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Therkelsen, Matthew D., Thomas Klose, Frank Vago, Wen Jiang, Michael G. Rossmann, and Richard J. Kuhn. "Flaviviruses have imperfect icosahedral symmetry." Proceedings of the National Academy of Sciences 115, no. 45 (October 22, 2018): 11608–12. http://dx.doi.org/10.1073/pnas.1809304115.

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Flaviviruses assemble initially in an immature, noninfectious state and undergo extensive conformational rearrangements to generate mature virus. Previous cryo-electron microscopy (cryo-EM) structural studies of flaviviruses assumed icosahedral symmetry and showed the concentric organization of the external glycoprotein shell, the lipid membrane, and the internal nucleocapsid core. We show here that when icosahedral symmetry constraints were excluded in calculating the cryo-EM reconstruction of an immature flavivirus, the nucleocapsid core was positioned asymmetrically with respect to the glyc

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Harrison, Jessica J., Jody Hobson-Peters, Helle Bielefeldt-Ohmann, and Roy A. Hall. "Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses." Vaccines 9, no. 11 (October 22, 2021): 1230. http://dx.doi.org/10.3390/vaccines9111230.

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Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some of these viruses, the ongoing efficacy, safety and supply of these vaccines are still a significant problem. New technologies that address these issues and ideally allow for the safe and economical manufacture of vaccines in resource-poor countries where flavivirus vaccines are in most demand are urgently required. Preferably a new vaccine plat

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Gwon, Yong-Dae, Mårten Strand, Richard Lindqvist, Emma Nilsson, Michael Saleeb, Mikael Elofsson, Anna K. Överby, and Magnus Evander. "Antiviral Activity of Benzavir-2 against Emerging Flaviviruses." Viruses 12, no. 3 (March 22, 2020): 351. http://dx.doi.org/10.3390/v12030351.

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Most flaviviruses are arthropod-borne viruses, transmitted by either ticks or mosquitoes, and cause morbidity and mortality worldwide. They are endemic in many countries and have recently emerged in new regions, such as the Zika virus (ZIKV) in South-and Central America, the West Nile virus (WNV) in North America, and the Yellow fever virus (YFV) in Brazil and many African countries, highlighting the need for preparedness. Currently, there are no antiviral drugs available to treat flavivirus infections. We have previously discovered a broad-spectrum antiviral compound, benzavir-2, with potent

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Silvia, Ondine J., Geoffrey R. Shellam, and Nadezda Urosevic. "Innate resistance to flavivirus infection in mice controlled by Flv is nitric oxide-independent." Journal of General Virology 82, no. 3 (March 1, 2001): 603–7. http://dx.doi.org/10.1099/0022-1317-82-3-603.

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Innate resistance to flaviviruses in mice is active in the brain where it restricts virus replication. This resistance is controlled by a single genetic locus, Flv, located on mouse chromosome 5 near the locus encoding the neuronal form of nitric oxide synthase (Nos1). Since nitric oxide (NO) has been implicated in antiviral activity, its involvement in natural resistance to flaviviruses has been hypothesized. Here we present data on NO production before and during flavivirus infection in both brain tissue and peritoneal macrophages from two flavivirus-resistant (Flv r) and one congenic suscep

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Carro, Stephen D., and Sara Cherry. "Beyond the Surface: Endocytosis of Mosquito-Borne Flaviviruses." Viruses 13, no. 1 (December 23, 2020): 13. http://dx.doi.org/10.3390/v13010013.

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Flaviviruses are a group of positive-sense RNA viruses that are primarily transmitted through arthropod vectors and are capable of causing a broad spectrum of diseases. Many of the flaviviruses that are pathogenic in humans are transmitted specifically through mosquito vectors. Over the past century, many mosquito-borne flavivirus infections have emerged and re-emerged, and are of global importance with hundreds of millions of infections occurring yearly. There is a need for novel, effective, and accessible vaccines and antivirals capable of inhibiting flavivirus infection and ameliorating dis

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Zhao, Rong, Meiyue Wang, Jing Cao, Jing Shen, Xin Zhou, Deping Wang, and Jimin Cao. "Flavivirus: From Structure to Therapeutics Development." Life 11, no. 7 (June 25, 2021): 615. http://dx.doi.org/10.3390/life11070615.

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Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are not well developed. The Flaviviridae family comprises a large group of enveloped viruses with a single-strand RNA genome of positive polarity. The genome of flavivirus encodes ten proteins, and each of them plays a different and important role in viral infection. In this review, we briefly summarized the major informa

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ISHIKAWA, Tomohiro, and Eiji KONISHI. "Flaviviruses." Uirusu 61, no. 2 (2011): 221–38. http://dx.doi.org/10.2222/jsv.61.221.

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Best, Sonja M. "Flaviviruses." Current Biology 26, no. 24 (December 2016): R1258—R1260. http://dx.doi.org/10.1016/j.cub.2016.09.029.

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Stiasny, Karin, Stefan Malafa, Stephan W. Aberle, Iris Medits, Georgios Tsouchnikas, Judith H. Aberle, Heidemarie Holzmann, and Franz X. Heinz. "Different Cross-Reactivities of IgM Responses in Dengue, Zika and Tick-Borne Encephalitis Virus Infections." Viruses 13, no. 4 (March 31, 2021): 596. http://dx.doi.org/10.3390/v13040596.

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Flaviviruses circulate worldwide and cause a number of medically relevant human diseases, such as dengue, Zika, yellow fever, and tick-borne encephalitis (TBE). Serology plays an important role in the diagnosis of flavivirus infections, but can be impeded by antigenic cross-reactivities among flaviviruses. Therefore, serological diagnosis of a recent infection can be insufficiently specific, especially in areas where flaviviruses co-circulate and/or vaccination coverage against certain flaviviruses is high. In this study, we developed a new IgM assay format, which is well suited for the specif

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Samuel, Glady Hazitha, Michael R. Wiley, Atif Badawi, Zach N. Adelman, and Kevin M. Myles. "Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA." Proceedings of the National Academy of Sciences 113, no. 48 (November 14, 2016): 13863–68. http://dx.doi.org/10.1073/pnas.1600544113.

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Mosquito-borne flaviviruses, including yellow fever virus (YFV), Zika virus (ZIKV), and West Nile virus (WNV), profoundly affect human health. The successful transmission of these viruses to a human host depends on the pathogen’s ability to overcome a potentially sterilizing immune response in the vector mosquito. Similar to other invertebrate animals and plants, the mosquito’s RNA silencing pathway comprises its primary antiviral defense. Although a diverse range of plant and insect viruses has been found to encode suppressors of RNA silencing, the mechanisms by which flaviviruses antagonize

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Hackett, Brent A., and Sara Cherry. "Flavivirus internalization is regulated by a size-dependent endocytic pathway." Proceedings of the National Academy of Sciences 115, no. 16 (April 2, 2018): 4246–51. http://dx.doi.org/10.1073/pnas.1720032115.

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Flaviviruses enter host cells through the process of clathrin-mediated endocytosis, and the spectrum of host factors required for this process are incompletely understood. Here we found that lymphocyte antigen 6 locus E (LY6E) promotes the internalization of multiple flaviviruses, including West Nile virus, Zika virus, and dengue virus. Perhaps surprisingly, LY6E is dispensable for the internalization of the endogenous cargo transferrin, which is also dependent on clathrin-mediated endocytosis for uptake. Since viruses are substantially larger than transferrin, we reasoned that LY6E may be req

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Wu, Bingan, Zhongtian Qi, and Xijing Qian. "Recent Advancements in Mosquito-Borne Flavivirus Vaccine Development." Viruses 15, no. 4 (March 23, 2023): 813. http://dx.doi.org/10.3390/v15040813.

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Lately, the global incidence of flavivirus infection has been increasing dramatically and presents formidable challenges for public health systems around the world. Most clinically significant flaviviruses are mosquito-borne, such as the four serotypes of dengue virus, Zika virus, West Nile virus, Japanese encephalitis virus and yellow fever virus. Until now, no effective antiflaviviral drugs are available to fight flaviviral infection; thus, a highly immunogenic vaccine would be the most effective weapon to control the diseases. In recent years, flavivirus vaccine research has made major brea

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Suzuki, Youichi, and Takeshi Murakawa. "Restriction of Flaviviruses by an Interferon-Stimulated Gene SHFL/C19orf66." International Journal of Molecular Sciences 23, no. 20 (October 20, 2022): 12619. http://dx.doi.org/10.3390/ijms232012619.

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Flaviviruses (the genus Flavivirus of the Flaviviridae family) include many arthropod-borne viruses, often causing life-threatening diseases in humans, such as hemorrhaging and encephalitis. Although the flaviviruses have a significant clinical impact, it has become apparent that flavivirus replication is restricted by cellular factors induced by the interferon (IFN) response, which are called IFN-stimulated genes (ISGs). SHFL (shiftless antiviral inhibitor of ribosomal frameshifting) is a novel ISG that inhibits dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encep

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Biering, Scott B., David L. Akey, Marcus P. Wong, W. Clay Brown, Nicholas T. N. Lo, Henry Puerta-Guardo, Francielle Tramontini Gomes de Sousa, et al. "Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction." Science 371, no. 6525 (January 7, 2021): 194–200. http://dx.doi.org/10.1126/science.abc0476.

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Medically important flaviviruses cause diverse disease pathologies and collectively are responsible for a major global disease burden. A contributing factor to pathogenesis is secreted flavivirus nonstructural protein 1 (NS1). Despite demonstrated protection by NS1-specific antibodies against lethal flavivirus challenge, the structural and mechanistic basis remains unknown. Here, we present three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, at resolutions between 2.89 and 3.96 angstroms. These structures r

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