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Journal articles on the topic 'Flavonoid Glucuronides'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Mues, Rüdiger, Gesine Leidinger, Vera Lauck, H. Dietmar Zinsmeister, Timo Koponen, and Kenneth R. Markham. "Rhizomnium magnifolium and R. pseudopunctatum, the First Mosses to Yield Flavone Glucuronides." Zeitschrift für Naturforschung C 41, no. 11-12 (1986): 971–75. http://dx.doi.org/10.1515/znc-1986-11-1203.

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Abstract Rhizomnium magnifolium and R. pseudopunctatum show an identical flavonoid pattern with six flavone glucuronides. Three of them; namely apometzgerin 7-O-glucuronide, selgin 7,5′-di-O-glucuronide and tricetin 7,3′-di-O-glucuronide are new natural compounds. This is the first report of flavonoid glucuronides in mosses.

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2

Yu, Yanhao, Yinquan Qu, Shuyang Wang, Qian Wang, Xulan Shang, and Xiangxiang Fu. "An Integrative Analysis of Metabolome and Transcriptome Reveals the Molecular Regulatory Mechanism of the Accumulation of Flavonoid Glycosides in Different Cyclocarya paliurus Ploidies." Forests 14, no. 4 (2023): 770. http://dx.doi.org/10.3390/f14040770.

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Cyclocarya paliurus (Batal) Iljinskaja is mainly used for harvesting leaves as materials for tea production and ingredients for the food industry. As its most important component, the contents of its total or specific flavonoids are supposed to vary at different ploidy levels. In the present study, two ploidy levels of C. paliurus are used to study their metabolome and transcriptome profiles. Though the total content of the flavonoids in leaves that were collected in September (the main harvesting season) presented insignificant differences between the two ploidies, flavonoid glucuronides were

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3

Bai, Yue, Lu Chen, Yun-Feng Cao, et al. "Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark." Planta Medica 87, no. 08 (2021): 631–41. http://dx.doi.org/10.1055/a-1402-6431.

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AbstractIntestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of various glucuronides into free aglycone, have been recognized as key targets for treating various intestinal diseases. This study aimed to investigate the inhibitory effects and mechanisms of the Mulberry bark constituents on E. coli β-glucuronidase (EcGUS), the most abundant β-glucuronidases produced by intestinal bacteria. The results showed that the flavonoids isolated from Mulberry bark could strongly inhibit E. coli β-glucuronidase, with IC50 values ranging from 1.12 µM to 10.63 µM, which were

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4

Uehara, Ayumi, Shinobu Akiyama, and Tsukasa Iwashina. "Foliar Flavonoids from Tanacetum vulgare var. boreale and their Geographical Variation." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000307.

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Foliar flavonoids of Tanacetum vulgare var. boreale were isolated. Eight flavonoid glycosides, 7- O-glucosides of apigenin, luteolin, scutellarein and 6-hydroxyluteolin, and 7- O-glucuronides of apigenin, luteolin, chrysoeriol and eriodictyol were identified. Moreover, eight flavonoid aglycones, apigenin, luteolin, hispidulin, nepetin, eupatilin, jaceosidin, pectolinarigenin and axillarin were also isolated and identified. The flavonoid composition of two varieties of T. vulgare, i.e. var. boreale and var. vulgare, were compared. All samples of var. boreale and one sample of var. vulgare had t

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5

O'Leary, Karen A., Andrea J. Day, Paul W. Needs, William S. Sly, Nora M. O'Brien та Gary Williamson. "Flavonoid glucuronides are substrates for human liver β-glucuronidase". FEBS Letters 503, № 1 (2001): 103–6. http://dx.doi.org/10.1016/s0014-5793(01)02684-9.

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6

Adiji, Olubu A., Maite L. Docampo-Palacios, Anislay Alvarez-Hernandez, Giulio M. Pasinetti, Xiaoqiang Wang, and Richard A. Dixon. "UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula." Plant Physiology 185, no. 4 (2021): 1617–37. http://dx.doi.org/10.1093/plphys/kiab016.

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Abstract Mammalian phase II metabolism of dietary plant flavonoid compounds generally involves substitution with glucuronic acid. In contrast, flavonoids mainly exist as glucose conjugates in plants, and few plant UDP-glucuronosyltransferase enzymes have been identified to date. In the model legume Medicago truncatula, the major flavonoid compounds in the aerial parts of the plant are glucuronides of the flavones apigenin and luteolin. Here we show that the M. truncatula glycosyltransferase UGT84F9 is a bi-functional glucosyl/glucuronosyl transferase in vitro, with activity against a wide rang

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7

Kamiya, Kohei, Yasuhisa Saiki, Takao Hama, et al. "Flavonoid glucuronides from Helicteres isora." Phytochemistry 57, no. 2 (2001): 297–301. http://dx.doi.org/10.1016/s0031-9422(01)00005-x.

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8

Afsharypuor, S., and G. B. Lockwood. "Flavonoid Glucuronides from Alyssum minimum." Journal of Natural Products 49, no. 5 (1986): 944–45. http://dx.doi.org/10.1021/np50047a041.

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9

Huang, Ying, Tess De Bruyne, Sandra Apers, et al. "Flavonoid glucuronides from Picria fel-terrae." Phytochemistry 52, no. 8 (1999): 1701–3. http://dx.doi.org/10.1016/s0031-9422(99)00242-3.

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10

Yang, Yan, Hui-Min Wang, Yuan-Feng Tong, et al. "Systems metabolic engineering of Escherichia coli to enhance the production of flavonoid glucuronides." RSC Advances 6, no. 40 (2016): 33622–30. http://dx.doi.org/10.1039/c6ra03304k.

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11

MOKHTAR, ALI NIA, and GUNASEKAR D. "Flavonoid Glucuronide from the Leaves of Clerodendron linearis." Journal of Indian Chemical Society Vol. 68, May 1991 (1991): 309. https://doi.org/10.5281/zenodo.6158161.

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Department of Chemistry, Sri Venkateswara University, Tirupati-517 502 <em>Manuscript received 25 March 1991, accepted 23 April 1991</em> Flavonoid Glucuronide from the Leaves of Clerodendron linearis.

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12

Schulz, Margot, and Gottfried Weissenböck. "Dynamics of the Tissue-Specific Metabolism of Luteolin Glucuronides in the Mesophyll of Rye Primary Leaves (Secale cereale)." Zeitschrift für Naturforschung C 43, no. 3-4 (1988): 187–93. http://dx.doi.org/10.1515/znc-1988-3-407.

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Developing primary leaves of Secale cereale L. exhibit a dynamic metabolism of the major flavonoid luteolin 7-O-[β-ᴅ-glucuronosyl(1→2)β-ᴅ-glucuronide]-4′-O-β-ᴅ-glucuronide (R1). Final steps of R, biosynthesis are sequential glucuronidations of luteolin, which are catalyzed by three specific UDP-glucuronate: flavone glucuronosyltransferases. These enzymes reach highest activities at the fourth and fifth day of leaf development, coinciding with maximal R, accumulation. The activities decrease with advancing age of the leaves. In contrast, a R1-specific β-glucuronidase, responsible for the hydrol

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13

Smolarz, H. D., J. Budzianowski, A. Bogucka-Kocka, J. Kocki, and E. Mendyk. "Flavonoid glucuronides with anti-leukaemic activity fromPolygonum amphibiumL." Phytochemical Analysis 19, no. 6 (2008): 506–13. http://dx.doi.org/10.1002/pca.1076.

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14

Budzianowsk, Jaromir, Krystyna Korzeniowska, Ewa Chmara, and Aleksander Mrozikiewicz. "Microvascular protective activity of flavonoid glucuronides fraction fromTulipa gesneriana." Phytotherapy Research 13, no. 2 (1999): 166–68. http://dx.doi.org/10.1002/(sici)1099-1573(199903)13:2<166::aid-ptr407>3.0.co;2-l.

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15

Zeng, Min, Rongjin Sun, Sumit Basu, et al. "Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides." Molecular Nutrition & Food Research 60, no. 5 (2016): 1006–19. http://dx.doi.org/10.1002/mnfr.201500692.

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16

Lee, Jin Seok, Yu Ran Nam, Su Jin Park, Ji Min Lee, Hyun Jong Kim, and Woo Kyung Kim. "Development and Evaluation of Topical Formulation Containing Agrimonia pilosa Extract." Applied Sciences 13, no. 13 (2023): 7672. http://dx.doi.org/10.3390/app13137672.

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Natural products are promising drug candidates with various pharmacological effects. However, they can be difficult to use due to poor bioavailability or low stability. In this experiment, while developing topical formulations containing 0.1% Agrimonia pilosa extract, a simple and rapid method of analyzing flavonoid glucuronides, which are representative ingredients, was developed and validated, and the physicochemical properties and stability of flavonoid glucuronides were observed. As a result, an optimized cream formulation was developed. The oil phase comprised tween 60, liquid paraffin, p

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17

Untergehrer, Monika, Daniel Bücherl, Hans-Joachim Wittmann, Andrea Strasser, Jörg Heilmann та Guido Jürgenliemk. "Structure-Dependent Deconjugation of Flavonoid Glucuronides by Human β-Glucuronidase – In Vitro and In Silico Analyses". Planta Medica 81, № 12/13 (2015): 1182–89. http://dx.doi.org/10.1055/s-0035-1545980.

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18

Kawai, Yoshichika. "β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents". Journal of Clinical Biochemistry and Nutrition 54, № 3 (2014): 145–50. http://dx.doi.org/10.3164/jcbn.14-9.

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19

Kaneko, Atsushi, Takashi Matsumoto, Yosuke Matsubara та ін. "Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β-glucuronidase in macrophages". Immunity, Inflammation and Disease 5, № 3 (2017): 265–79. http://dx.doi.org/10.1002/iid3.163.

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20

Conrad, Jürgen, Bernhard Förster-Fromme, Mihaela-Anca Constantin, et al. "Flavonoid Glucuronides and a Chromone from the Aquatic MacrophyteStratiotes aloides." Journal of Natural Products 72, no. 5 (2009): 835–40. http://dx.doi.org/10.1021/np800769g.

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21

Karimov, A. M., T. N. Slobodyanyuk, and E. Kh Botirov. "New Flavonoid Glucuronides from the Aerial Part of Scutellaria intermedia." Chemistry of Natural Compounds 53, no. 4 (2017): 638–41. http://dx.doi.org/10.1007/s10600-017-2079-z.

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22

Mira, Amira, Wael Alkhiary, and Kuniyoshi Shimizu. "Antiplatelet and Anticoagulant Activities of Angelica shikokiana Extract and Its Isolated Compounds." Clinical and Applied Thrombosis/Hemostasis 23, no. 1 (2016): 91–99. http://dx.doi.org/10.1177/1076029615595879.

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Angelica shikokiana is a Japanese medicinal plant that is used traditionally in several ailments of cardiovascular diseases. However, there is no report regarding its anticoagulant or antiplatelet activities. So this study was designed to screen for such activities (anticoagulant by prothrombin time [PT], activated partial thromboplastin time, and thrombin time assays and antiplatelet activities against adenosine 5′-diphosphate [ADP] and arachidonic acid-induced platelet aggregations) for the methanol extract of the aerial part ( Angelica methanol extract [AME]), its isolated coumarins, flavon

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23

Kim, So Yeon, Hye Rin Lee, Kwang-su Park, Bong-Gyu Kim, and Joong-Hoon Ahn. "Metabolic engineering of Escherichia coli for the biosynthesis of flavonoid-O-glucuronides and flavonoid-O-galactoside." Applied Microbiology and Biotechnology 99, no. 5 (2014): 2233–42. http://dx.doi.org/10.1007/s00253-014-6282-6.

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24

Jiang, Haodong, Huan Liu, Pei Hu, et al. "Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin." Separations 9, no. 5 (2022): 115. http://dx.doi.org/10.3390/separations9050115.

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Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitative and quantitative analyses of calycosin and its metabolites in portal vein plasma, the liver, and systemic plasma after oral administration to rats. Consequently, 21 metabolites were characterized in total, including the first report of a reductive biotransformation and 14 new metabolites. Compared with the low levels of calycosin, calycosin glucuronides w

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25

Vasileva, A. M., I. A. Iliev, V. S. Lozanov, M. B. Dimitrova, V. I. Mitev, and I. P. Ivanov. "In vitro study on the antitumor activity of Tanacetum vulgare L. extracts." Bulgarian Chemical Communications 51, no. 2 (2019): 249–55. http://dx.doi.org/10.34049/bcc.51.2.5035.

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The major nonvolatile compounds derived from extracts and fractions from Tanacetum vulgare L. flowers were determined by LC–HRMS. Major compounds in the crude extract were determined to be: six hydroxycinnamoyl quinic acids with 4,5-dicaffeoylquinic acid and twelve flavonoids and their derivatives, six of which were in the form of flavonoid-O-glucuronides. Generally, the major flavonoid aglycone in tansy was luteolin. Extracts and fractions were tested under in vitro conditions in nine cell lines - one control non-tumorogenic and eight tumor lines, whereby antitumor activity was observed after

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26

Zhang, Qingzhi, K. Saki Raheem, Nigel P. Botting, Alexandra M. Z. Slawin, Colin D. Kay, and David O'Hagan. "Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids." Tetrahedron 68, no. 22 (2012): 4194–201. http://dx.doi.org/10.1016/j.tet.2012.03.100.

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27

Lu, Qing-Yi, Lifeng Zhang, Guido Eibl та Vay Liang W. Go. "Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase". Journal of Pharmaceutical and Biomedical Analysis 88 (січень 2014): 364–69. http://dx.doi.org/10.1016/j.jpba.2013.09.013.

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28

Jiang, Xue-Yang, Xin-Chen Li, Wen-Yuan Liu, Yun-Hui Xu, Feng Feng, and Wei Qu. "An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond." Tetrahedron 73, no. 14 (2017): 1895–903. http://dx.doi.org/10.1016/j.tet.2017.02.039.

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29

Schulz, Margot, and Gottfried Weissenböck. "Isolation and Separation of Epidermal and Mesophyll Protoplasts from Rye Primary Leaves — Tissue-Specific Characteristics of Secondary Phenolic Product Accumulation." Zeitschrift für Naturforschung C 41, no. 1-2 (1986): 22–27. http://dx.doi.org/10.1515/znc-1986-1-205.

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Abstract We have develop ed a technique for the large-scale isolation of epidermal and mesophyll protoplasts, as well as the vascular strands, of rye primary leaf blades. Separation of the two types of protoplasts has been successful only from leaves harvested at the end of a 13-h light period, when chloroplasts were enriched in starch. The occurrence of different flavonoid compounds, and amounts, in epidermal and mesophyll protoplasts can be used as criteria for protoplast purity and viability since C-glucosylflavone O-glycosides are characteristic of epidermal protoplasts whereas flavone O-

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30

Kaneko, Atsushi, Setsuya Aiba, and Kenshi Yamasaki. "Enhancement of macrophage functions by flavonoid glucuronides via deconjugation and agonism for nuclear estrogen receptors in macrophages." Journal of Dermatological Science 86, no. 2 (2017): e91. http://dx.doi.org/10.1016/j.jdermsci.2017.02.266.

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31

Davis, Barry D., Paul W. Needs, Paul A. Kroon, and Jennifer S. Brodbelt. "Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS." Journal of Mass Spectrometry 41, no. 7 (2006): 911–20. http://dx.doi.org/10.1002/jms.1050.

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32

Moriwaki, Masamitsu, Etsuko Tominaga, Kento Kito та ін. "Bioavailability of Flavonoids in Ginkgo biloba Extract-γ-Cyclodextrin Complex". Natural Product Communications 18, № 5 (2023): 1934578X2311702. http://dx.doi.org/10.1177/1934578x231170221.

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Ginkgo biloba extract (GBE) is an essential herbal supplement for diverse health perspectives. The present study aims to improve the oral bioavailability of GBE flavonoids. We formulated the GBE flavonoids-cyclodextrin (GBE-CD) complex by reacting GBE flavonoids with naringinase in the presence of γ-cyclodextrin (CD) using a patented method. The results showed an enhanced bioavailability of quercetin (QCT), kaempferol (KAE), and isorhamnetin (ISR) after β-glucuronidase catalysis of flavonoid glucuronide conjugates in plasma after GBE-CD (25 μmol/kg as QCT equivalence) administration, that was

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33

Yung-Qi, Wang, Keiichi Matsuzaki, Kunio Takahashi, Toru Okuyama, and Shoji Shibata. "Studies of the constituents of scutellaria species. I. The flavonoid glucuronides of "bo ye huang chin", Scutellaria ikonnikovii JUZ." CHEMICAL & PHARMACEUTICAL BULLETIN 36, no. 8 (1988): 3206–9. http://dx.doi.org/10.1248/cpb.36.3206.

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34

Ślusarczyk, Sylwester, Kajetan Grzelka, Joanna Jaśpińska, et al. "Changes in Growth and Metabolic Profile of Scutellaria baicalensis Georgi in Response to Sodium Chloride." Biology 13, no. 12 (2024): 1058. https://doi.org/10.3390/biology13121058.

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Scutellaria baicalensis Georgi is a valuable medicinal plant of the Lamiaceae family. Its roots have been used in Traditional Chinese Medicine (under the name Huang-qin) since antiquity and are nowadays included in Chinese and European Pharmacopoeias. It is abundant in bioactive compounds which constitute up to 20% of dried root mass. These substances are lipophilic flavones with unsubstituted B-ring, baicalein, and wogonin and their respective glucuronides–baicalin and wogonoside being the most abundant. The content of these compounds is variable and the environmental factors causing this rem

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35

Davis, Barry D., and Jennifer S. Brodbelt. "Regioselectivity of human UDP-glucuronosyl-transferase 1A1 in the synthesis of flavonoid glucuronides determined by metal complexation and tandem mass spectrometry." Journal of the American Society for Mass Spectrometry 19, no. 2 (2008): 246–56. http://dx.doi.org/10.1016/j.jasms.2007.11.004.

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36

Ko, Jung-Hwan, Youn Hee Nam, Sun-Woo Joo, et al. "Flavonoid 8-O-Glucuronides from the Aerial Parts of Malva verticillata and Their Recovery Effects on Alloxan-Induced Pancreatic Islets in Zebrafish." Molecules 23, no. 4 (2018): 833. http://dx.doi.org/10.3390/molecules23040833.

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37

Kim, Young Woo, Hee Eun Kang, Myung Gull Lee, et al. "Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes." American Journal of Physiology-Gastrointestinal and Liver Physiology 296, no. 2 (2009): G372—G381. http://dx.doi.org/10.1152/ajpgi.90524.2008.

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Liquiritigenin (LQ), an active component of licorice, has an inhibitory effect on LPS-induced inhibitory nitric oxide synthase expression. This study investigated the effects of LQ on choleresis, the expression of hepatic transporters and phase-II enzymes, and fulminant hepatitis. The choleretic effect and the pharmacokinetics of LQ and its glucuronides were monitored in rats. After intravenous administration of LQ, the total area under the plasma concentration-time curve of glucuronyl metabolites was greater than that of LQ in plasma, which accompanied elevations in bile flow rate and biliary

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38

Dyer, Joanne, Diego Tamburini, Naomi Speakman, and Caroline R. Cartwright. "Hidden Treasures: Precious Textiles from the St Eustace Head Reliquary." Heritage 8, no. 6 (2025): 206. https://doi.org/10.3390/heritage8060206.

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Almost 70 years after the surprise discovery of a cache of textile-wrapped relics inside an early 13th-century reliquary bust, the St Eustace head reliquary (accession number 1850,1127.1), four of the textile relic wrappings were analysed by combining multiband imaging and fibre-optic reflectance spectroscopy (FORS), as well as dye analysis by high-pressure liquid chromatography coupled to mass spectrometry (HPLC-MS) and fibre analysis by scanning electron microscopy—energy dispersive X-ray spectroscopy (SEM-EDX). In all cases, the use of silk was confirmed, in line with the idea that these pr

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39

Żyżyńska-Granica, Barbara, Barbara Gierlikowska, Andrzej Parzonko, Anna K. Kiss, and Sebastian Granica. "The bioactivity of flavonoid glucuronides and free aglycones in the context of their absorption, II phase metabolism and deconjugation at the inflammation site." Food and Chemical Toxicology 135 (January 2020): 110929. http://dx.doi.org/10.1016/j.fct.2019.110929.

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40

Tu, Yifan, Lei Zhou, Li Li, Lu Wang, Song Gao, and Ming Hu. "Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study." Analytical Biochemistry 601 (July 2020): 113723. http://dx.doi.org/10.1016/j.ab.2020.113723.

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41

Ali, Fahad, and Yasir Hasan Siddique. "Bioavailability and Pharmaco-therapeutic Potential of Luteolin in Overcoming Alzheimer’s Disease." CNS & Neurological Disorders - Drug Targets 18, no. 5 (2019): 352–65. http://dx.doi.org/10.2174/1871527318666190319141835.

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Luteolin is a naturally occurring, yellow crystalline flavonoid found in numerous dietary supplements we frequently have in our meals. Studies in the last 2 decades have revealed its therapeutic potential to reduce the Alzheimer’s disease (AD) symptoms in various in vitro and in vivo models. The anti-Alzheimer’s potential of luteolin is attributed to its ability to suppress A&#946; as well as tau aggregation or promote their disaggregation, down-regulate the expression of COX-2, NOS, MMP-9, TNF-&#945;, interleukins and chemokines, reduce oxidative stress by scavenging ROS, modulate the

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42

O’Leary, Karen A., Andrea J. Day, Paul W. Needs, Fred A. Mellon, Nora M. O’Brien та Gary Williamson. "Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism". Biochemical Pharmacology 65, № 3 (2003): 479–91. http://dx.doi.org/10.1016/s0006-2952(02)01510-1.

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43

Nørskov, Natalja P., Annette Bruhn, Andrew Cole, and Mette Olaf Nielsen. "Targeted and Untargeted Metabolic Profiling to Discover Bioactive Compounds in Seaweeds and Hemp Using Gas and Liquid Chromatography-Mass Spectrometry." Metabolites 11, no. 5 (2021): 259. http://dx.doi.org/10.3390/metabo11050259.

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Greenhouse gas emissions are a global problem facing the dairy/beef industry. Novel feed additives consisting of seaweeds and hemp containing bioactive compounds are theorized to reduce enteric methane emissions. In this study we aimed to investigate the metabolic profiles of brown, red and green seaweeds and hemp using gas chromatography and liquid chromatography mass spectrometry. We used targeted and untargeted approaches, quantifying known halomethanes and phenolics, as well as identifying potentially novel bioactive compounds with anti-methanogenic properties. The main findings were: (a)

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44

Rendeiro, Catarina, Honglin Dong, Caroline Saunders, et al. "Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study." British Journal of Nutrition 116, no. 12 (2016): 1999–2010. http://dx.doi.org/10.1017/s0007114516004219.

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AbstractSpecific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0–7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30–65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg;

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45

Tremmel, Martina, Christian Paetz, and Jörg Heilmann. "In Vitro Liver Metabolism of Six Flavonoid C-Glycosides." Molecules 26, no. 21 (2021): 6632. http://dx.doi.org/10.3390/molecules26216632.

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Several medical plants belonging to the genera Passiflora, Viola, and Crataegus accumulate flavonoid C-glycosides, which likely contribute to their efficacy. Information regarding their phase I and II metabolism in the liver are lacking. Thus, in vitro liver metabolism of orientin, isoorientin, schaftoside, isoschaftoside, vitexin, and isovitexin, all of which accumulated in Passiflora incarnata L., was investigated by incubation in subcellular systems with human liver microsomes and human liver S9 fraction. All metabolite profiles were comprehensively characterized using HPLC-DAD and UHPLC–MS

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Shang, Xianchao, Jia-Neng Tan, Yongmei Du, Xinmin Liu, and Zhongfeng Zhang. "Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities." Molecules 23, no. 9 (2018): 2110. http://dx.doi.org/10.3390/molecules23092110.

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Deep eutectic solvents (DESs) are commonly employed as environmentally-friendly solvents in numerous chemical applications owing to their unique physicochemical properties. In this study, a novel and environmentally-friendly extraction method based on ultrasound assisted-deep eutectic solvent extraction (UAE-DES) was investigated for the extraction of flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus) leaves, and the antioxidant activities of these flavonoids were evaluated. Nine different DES systems based on either two or three components were tested, and the choline chlor

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Hennebelle, Thierry, Sevser Sahpaz, Henry Joseph, and François Bailleul. "Phenolics and Iridoids of Lippia Alba." Natural Product Communications 1, no. 9 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100906.

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The phytochemical investigation of polar extracts of Lippia alba led to the isolation of a new acetylated flavonoid, apigenin-7-O-[(3-O-acetyl)β-D-glucopyranuronyl(1→2)]-β-D-glucopyranuronide, and of seventeen known compounds: seven iridoids (theveside, geniposidic acid, shanzhiside methyl ester, caryoptoside, 8-epi-loganin, mussaenoside and geniposide), six phenylpropanoids (cistanoside F, forsythoside B, calceolarioside E, acteoside, isoacteoside and 2-acetylacteoside) and four flavonoids (apigenin-7-O-glucuronide, luteolin-7-O-glucuronide, apigenin-7-O-diglucuronide and luteolin-7-O-diglucu

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Rozario, M. Jerome, and Dr A. John Merina. "The flavonoid Quercetin-3-O-glucuronide from Nelumbo nucifera." Indian Journal of Applied Research 2, no. 1 (2011): 6–7. http://dx.doi.org/10.15373/2249555x/oct2012/3.

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Liu, Jingli, Yingying Xue, Hao Yan, Jing Zhou, Xu Long та Yuping Tang. "Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies". Molecules 30, № 6 (2025): 1324. https://doi.org/10.3390/molecules30061324.

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Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs. Licorice, a traditional Chinese medicine, harmonizes various herbs and mitigates the toxicity of hundreds of herbs. In this study, a comprehensive computational strategy was employed to evaluate four licorice flavonoids (liquiritigenin, isoliquiritigenin, liquiritin, and isoliquiritin) as potential Escherichia coli β-glucuronidase (EcGUS) inhibitors. Density functional theory was used to deter

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Koseki, Junichi, Atsushi Kaneko, Yosuke Matsubara, et al. "Keigairengyoto, a traditional Japanese medicine, promotes bacterial clearance by activating innate immune cells in mouse cutaneous infection models." Trends in Immunotherapy 3, no. 1 (2019): 26. http://dx.doi.org/10.24294/ti.v3.i1.31.

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Prompt elimination of pathogens including bacteria and dead cells prevents the expansion of secondary and prolonged inflammations and tissue damage. Keigairengyoto (KRT) is a traditional Japanese medicine prescribed for dermatoses such as purulent inflammations. Our aim is to clarify the actions of KRT in bacterial clearance and to examine the cell-kinetic profiles of phagocytes. In a mouse cutaneous infection model using living Staphylococcus aureus, KRT drastically reduced the number of bacteria in the infection sites. To evaluate the bacterial clearance, pseudo-infection was induced in mous

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