Relevant bibliographies by topics / Flavonoid hydroxylation

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Flavonoid hydroxylation'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Flavonoid hydroxylation"

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Ma, Dawei, Hao Tang, Michael Reichelt, et al. "Poplar MYB117 promotes anthocyanin synthesis and enhances flavonoid B-ring hydroxylation by up-regulating the flavonoid 3′,5′-hydroxylase gene." Journal of Experimental Botany 72, no. 10 (2021): 3864–80. http://dx.doi.org/10.1093/jxb/erab116.

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Abstract Flavonoids, such as anthocyanins, proanthocyanidins, and flavonols, are widespread plant secondary metabolites and important for plant adaptation to diverse abiotic and biotic stresses. Flavonoids can be variously hydroxylated and decorated; their biological activity is partly dependent on the degree of hydroxylation of the B-ring. Flavonoid biosynthesis is regulated by MYB transcription factors, which have been identified and characterized in a diversity of plants. Here we characterize a new MYB activator, MYB117, in hybrid poplar (Populus tremula×tremuloides). When overexpressed in
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Stich, K., and G. Forkmann. "Enzymatic Synthesis of 4′-and 3′, 4′ -Hydroxylated Flavanones and Flavones with Flower Extracts of Sinningia cardinalis." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1193–99. http://dx.doi.org/10.1515/znc-1987-11-1210.

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Flowers of Sinningia (syn. Rechsteineria) cardinalis contain glycosides of the flavones apigenin (4′-OH) and luteolin (3′,4′-OH) respectively, and of the related 3-deoxyanthocyanidins apigeninidin and luteolinidin. Studies on substrate specificity of the key enzyme of flavonoid biosynthesis, chalcone synthase, revealed that the 3′,4′-hydroxylated flavonoids are formed by hydroxylation of flavonoid compounds rather than by incorporation of caffeoyl-CoA into the flavonoid skeleton during the condensation reaction. In fact, flavonoid 3′-hydroxylase activity could be demonstrat­ed in the microsoma
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Amor, Ilef Limem-Ben, Nidhal Salem, Emmanuel Guedon, Jean-Marc Engasser, Leila Chekir-Ghedrira, and Mohamed Ghoul. "Preliminary Investigation of Naringenin Hydroxylation with Recombinant E. coli Expressing Plant Flavonoid Hydroxylation Gene." Natural Product Communications 5, no. 5 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500520.

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Flavonoid hydroxylation is one way to increase the biological activities of these molecules and the number of hydroxyl groups needed for polymerization, esterification, alkylation, glycosylation and acylation reactions. These reactions have been suggested as a promising route to enhance flavonoid solubility and stability. In our preliminary study we hydroxylated naringenin (the first flavonoid core synthesized in plants) with recombinant E. coli harboring flavanone 3 hydroxylase (F3H). We demonstrated that recombinant E. coli harboring the F3H from Petroselinum crispum, can convert naringenin
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Amor, Ilef Limem-Ben, Alain Hehn, Emmanuel Guedon, et al. "Biotransformation of Naringenin to Eriodictyol by Saccharomyces cerevisiea Functionally Expressing Flavonoid 3′ Hydroxylase." Natural Product Communications 5, no. 12 (2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501211.

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To increase the biological activities of flavonoids and to enhance their stability and solubility by functionalization reactions (polymerization, esterification, alkylation, glycosylation and acylation), an increase in the number of hydroxyl groups in these molecules is needed. Hydroxylation reactions may be achieved using either chemical or enzymatic methods, the latter being more highly specific than the former. In our study, the flavonoid 3′ hydroxylase (F3′H) from Gerbera hybrid, functionally expressed in Saccharomyces cerevisiae, was used to hydroxylate naringenin (the first flavonoid cor
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Benković, Goran, Mirza Bojić, Željan Maleš, and Siniša Tomić. "Screening of flavonoid aglycons’ metabolism mediated by the human liver cytochromes P450." Acta Pharmaceutica 69, no. 4 (2019): 541–62. http://dx.doi.org/10.2478/acph-2019-0039.

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Abstract Biological effects of flavonoids have been extensively studied in the last 80 years. As flavonoids represent a rather large group of compounds, data on metabolic biotransformations of these compounds is relatively limited to those well studied. The objective of this study was to screen the metabolism of 30 selected flavonoid aglycons mediated by the most relevant metabolic enzymes, human liver cytochromes P450. For this purpose, in vitro experiments with human liver microsomes and recombinant enzymes were conducted. To evaluate flavonoid’s metabolism and structure of the products, hig
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Larson, R., J. B. Bussard, and E. H. Coe. "Gene-dependent flavonoid 3′-hydroxylation in maize." Biochemical Genetics 24, no. 7-8 (1986): 615–24. http://dx.doi.org/10.1007/bf00504338.

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Resende, Flávia Aparecida, Leonardo Gorla Nogueira, Tais Maria Bauab, Wagner Vilegas, and Eliana Aparecida Varanda. "Antibacterial potential of flavonoids with different hydroxylation patterns." Eclética Química Journal 40, no. 1 (2015): 173. http://dx.doi.org/10.26850/1678-4618eqj.v40.1.2015.p173-179.

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The antibacterial activity of ten flavonoids, with variations in the hydroxylation pattern, was assayed in this study with the aim of investigating the influence of the hydroxyl groups of flavonoids on the evaluated activity. The evaluated degree of hydroxylation of the flavonoid molecules appears to have a crucial role in antibacterial effects. Kaempferol, the most active compound against Staphylococcus aureus, has a hydroxyl group in the B ring, a double bond between carbons 2 and 3 in conjunction with a 4-carbonyl group and hydroxyl groups at positions 3, 5 and 7, showing that the hydrophil
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Ioannou, Irina, Alexandre Kriznik, Leila Chekir, and Mohamed Ghoul. "Effect of the Processing Temperature on the Degradation of Food Flavonoids: Kinetic and Calorimetric Studies on Model Solutions." Journal of Food Engineering and Technology 8, no. 2 (2019): 91–102. http://dx.doi.org/10.32732/jfet.2019.8.2.91.

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Food flavonoids have a high antioxidant activity that make them bioactive to fight oxidation. However, when they are used in different formulations, these bioactive molecules are often the subject of at least one heat treatment step such as cooking, pasteurization. To establish the sensitivity of these molecules to heat treatment, the kinetics of degradation of 4 flavonoid extracts were evaluated under isothermal and non-isothermal conditions. The flavonoids tested belong to the aglycon (eriodictyol and mesquitol) and glycosylated (rutin, naringin) forms. The glycosylated flavonoids have a hig
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Weissensteiner, Julia, Christian Molitor, Silvija Marinovic, et al. "Molecular and Enzymatic Characterization of Flavonoid 3′-Hydroxylase of Malus × domestica." Plants 10, no. 9 (2021): 1956. http://dx.doi.org/10.3390/plants10091956.

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Malus × domestica (apple) accumulates particularly high amounts of dihydrochalcones in various tissues, with phloridzin (phloretin 2′-O-glucoside) being prevalent, although small amounts of 3-hydroxyphloretin and 3-hydroxyphloridzin are also constitutively present. The latter was shown to correlate with increased disease resistance of transgenic M. × domestica plants. Two types of enzymes could be involved in 3-hydroxylation of dihydrochalcones: polyphenol oxidases or the flavonoid 3′-hydroxylase (F3′H), which catalyzes B-ring hydroxylation of flavonoids. We isolated two F3′H cDNA clones from
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Bojić, Mirza, Martin Kondža, Hrvoje Rimac, Goran Benković, and Željan Maleš. "The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity." Molecules 24, no. 17 (2019): 3174. http://dx.doi.org/10.3390/molecules24173174.

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Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed. Flavonoids are natural compounds to which humans are exposed through everyday diet. In the previous study, selected flavonoid aglycones showed inhibition of CYP3A4 enzyme. Thus, the objective of this study was to determine if these flavonoids inhibit metabolic activity of CYP1A2, CYP2A6, CYP2C8, and CYP2D6 enzymes. For this purpose, the O-deethylation reaction of phenacetin was use
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Dissertations / Theses on the topic "Flavonoid hydroxylation"

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Nasri, Ruba. "Mechanisms of interactions between flavonols and recombinant CpLIP2 lipase from Candida parapsilosis : enzymatic and biophysical approaches." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTG062.

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Cette thèse de doctorat vise à étudier les mécanismes d'interactions entre la lipase / acyltransférase CpLIP2 recombinante de Candida parapsilosis et 4 flavonols qui se distinguent par un degré d’hydroxylation croissant sur le cycle B (galangine, kaempferol, quercétine et myricétine). Notre stratégie a intégré 3 approches complémentaires : enzymatique, biophysique et le docking moléculaire. Tout d'abord, les effets inhibiteurs des 4 flavonols et de la tétrahydrolipstatine (THL) en tant qu'inhibiteur de référence des lipases ont été étudiés en déterminant l’activité d’hydrolyse d’oléate d’éthyl
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Barková, Kateřina. "Enzymatische Transformation verschiedener Flavonoide durch das extrazelluläre Pilzenzym Agrocybe-aegerita-Peroxygenase." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-124760.

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Die enzymatischen Transformationen mit der pilzlichen Peroxygenase aus Agrocybe aegerita haben gezeigt, dass das Enzym insgesamt über ein sehr breites Substratspektrum bezüglich der Flavonoide verfügt. Die Flavonoide werden mittels AaeAPO regioselektiv in 6-Position hydroxyliert. Der Reaktionsmechanismus der AaeAPO bei Flavonoiden läuft über eine Epoxidstufe ab, wobei der eingefügte Sauerstoff bei Hydroxylierungen dem Wasserstoffperoxid entstammt (Hinweis auf eine echte Peroxygenase-Reaktion). Die Enzymproduktion der Agrocybe aegerita wird durch den Extraktzusatz (aus jeweils Aronia melanocarp
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Zifkin, Michael. "Flavonoid gene expression and metabolite profiling during fruit development in highbush blueberry (Vaccinium corymbosum L.)." Thesis, 2010. http://hdl.handle.net/1828/3658.

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Highbush blueberry (Vaccinium corymbosum L.) has one of the highest antioxidant capacities and flavonoid concentrations of any fruit or vegetable, and regular consumption of blueberries has been connected to a wide range of health benefits. A diversity of flavonoids (flavonols, anthocyanins, proanthocyanidins) are likely responsible for many of the health benefits, and these compounds also significantly contribute to the organoleptic properties of ripe blueberries. Despite the potential importance of these flavonoids in diet, there has been little investigation into the molecular genetics of b
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4

Tsai, Yi-Hsuan, and 蔡以萱. "Inhibition of Melanogenesis by Yeast Extracts from Cultivations of Recombinant Pichia pastoris Catalyzing ortho-Hydroxylation of Flavonoids." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/54425885589943019692.

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碩士<br>國立臺南大學<br>生物科技學系碩士班<br>103<br>The inhibition of melanogenesis by yeast extracts from cultiva¬tions of recombinant Pichia pastoris catalyzing ortho-hydroxylation of flavonoids was investigated. The recombinant yeast harbored a fu¬sion gene composed of the CYP57B3 gene from Aspergillus oryzae and a cytochrome reductase gene from Saccharomyces cerevisiae. Ten flavonoids belonging to flavones, flavonols, flavanones, fla¬vanols, and isoflavones were evaluated for biotransformation by the re¬combinant strain. The results showed that five flavonoids, includ¬ing the flavone apigenin, the flavano
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Barková, Kateřina. "Enzymatische Transformation verschiedener Flavonoide durch das extrazelluläre Pilzenzym Agrocybe-aegerita-Peroxygenase." Doctoral thesis, 2012. https://tud.qucosa.de/id/qucosa%3A27198.

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Die enzymatischen Transformationen mit der pilzlichen Peroxygenase aus Agrocybe aegerita haben gezeigt, dass das Enzym insgesamt über ein sehr breites Substratspektrum bezüglich der Flavonoide verfügt. Die Flavonoide werden mittels AaeAPO regioselektiv in 6-Position hydroxyliert. Der Reaktionsmechanismus der AaeAPO bei Flavonoiden läuft über eine Epoxidstufe ab, wobei der eingefügte Sauerstoff bei Hydroxylierungen dem Wasserstoffperoxid entstammt (Hinweis auf eine echte Peroxygenase-Reaktion). Die Enzymproduktion der Agrocybe aegerita wird durch den Extraktzusatz (aus jeweils Aronia melanocarp
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6

Zhang, Jingwen, J. R. Marsh, A. Tait, et al. "Methoxylated but not hydroxylated flavones elicit significant activity against Parp-1-mediated cell death (Parthanatos)." 2017. http://hdl.handle.net/10454/12400.

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no<br>Flavonoids, of which flavones are a sub-group, are plant secondary metabolites found in a variety of natural food sources (e.g., vegetables) and wines. They elicit beneficial roles in health and disease through their antioxidant activity, but some of them have also now been found to exert specific effects on cell signalling. We recently showed that methoxylation of the flavone structure at the 4ʹ position, or additionally at the 3ʹ position, to produce 4ʹ-methoxyflavone (4MF) and 3ʹ,4ʹ-dimethoxyflavone (DMF), respectively, significantly enhanced activity against the cell death (“parth
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Book chapters on the topic "Flavonoid hydroxylation"

1

Pengelly, Andrew. "Polyphenols - tannins and flavonoids." In The constituents of medicinal plants, 3rd ed. CABI, 2021. http://dx.doi.org/10.1079/9781789243079.0003.

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Abstract Polyphenol compounds are those with two or more benzene rings, with varying degrees of hydroxylation in each ring. The name has become almost synonymous with dietary antioxidants. In this chapter, readers were introduced to lignans and stilbenes, both examples of polyphenol compounds. The focus of this chapter is on the two largest subcategories of polyphenols such as tannins and flavonoids.
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