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Dissertations / Theses on the topic 'Flavonoli'

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Published: 9 March 2023
Last updated: 31 July 2025

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1

McIntosh, Cecilia A. "Position-Specific Flavonoid Glucosyltransferases: Structure and Functional Analysis of Grapefruit Flavonol-Specific 3-O-GT." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/367.

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2

Owens, Daniel Kenneth. "Examination of 2-Oxoglutarate Dependant Dioxygenases Leading to the Production of Flavonols in Arabidopsis thaliana." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29144.

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The flavonols are a varied and abundant sub-class of flavonoids that are associated with a number of essential physiological functions in plants and pharmacological activities in animals. The 2-oxoglutarate-dependant dioxygenases(2-ODDs), flavonol synthase (FLS) and flavanone 3-hydroxylase (F3H), are essential for flavonol synthesis. The primary goal of this study has been to gain a deeper understanding of the biochemistry of these enzymes in Arabidopsis. To accomplish this goal, an activity assay employing recombinant protein expression and HPLC as a detection system was developed for F3H an
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3

Reinboth, Marianne. "Bioverfügbarkeit des Flavonols Quercetin beim Hund." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-62483.

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6 Zusammenfassung Marianne Reinboth Bioverfügbarkeit des Flavonols Quercetin beim Hund Veterinär-Physiologisches Institut der Veterinärmedizinischen Fakultät der Universität Leipzig Eingereicht im Juni 2010 79 Seiten, 20 Abbildungen, 6 Tabellen, 211 Literaturangaben, 1 Anhang Schlüsselwörter: Quercetin, Bioverfügbarkeit, Hund, absolute Bioverfügbarkeit, Isoquercitrin, Rutin, Flavonole Für das pflanzliche Flavonol Quercetin werden vielfältige gesundheitsfördernde Wirkungen postuliert, so auch bei Hunden. Über die Bioverfügbarkeit des Flavonols bei dieser Spezies liegen bislang jedoch keinerlei
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4

Costa, Patricia Miranda da. "Triterpenos, saponinas e flavono?des de L. arianeae (Chrysobalanaceae) e Eschweilera longipes (Lecythidaceae)." Universidade Federal Rural do Rio de Janeiro, 2003. https://tede.ufrrj.br/jspui/handle/jspui/1561.

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Submitted by Leticia Schettini (leticia@ufrrj.br) on 2017-04-27T12:32:10Z No. of bitstreams: 1 2003 - Patricia Miranda da Costa.pdf: 2556665 bytes, checksum: 84eaee321ba021876a1fd855d0767602 (MD5)<br>Made available in DSpace on 2017-04-27T12:32:10Z (GMT). No. of bitstreams: 1 2003 - Patricia Miranda da Costa.pdf: 2556665 bytes, checksum: 84eaee321ba021876a1fd855d0767602 (MD5) Previous issue date: 2003-11-28<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Solvent partition and chromatographic fractionation of metanolic extract from the leaves and wood of L. arianeae l
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5

Jailani, Fadhilah. "Absorption and metabolism of flavonols." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634526.

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The consumption of flavonols, major sources of dietary flavonoids, have been linked to the reduction of risk factors for various chronic diseases. However, the bioavailability of flavonols would appear to be limited and not all compounds within the same subclass are absorbed with equal efficacy, thus compromising their nutritional relevance. The aim of this current study was to examine the absorption and metabolism of four major flavonols specifically quercetin, myricetin, kaempferol and galangin using both in vitro methods and healthy human volunteers to investigate how bioavailability was af
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6

De, Marchi Fabiola. "Studio dei metaboliti chimici dell'uva finalizzato a valutare le potenzialità enologiche, nutraceutiche ed industriali di alcune varietà di vite e nuovi approcci di metabolomica." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423516.

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Grape, wine and oenology by-products are rich in polyphenols and in particular flavonoids: flavonols, anthocyanins, flavanols and proanthocyanidins. Those molecules are plants secondary metabolites and may also contribute to the bitterness and astringency of grapes and wines. In recent years, epidemiological studies have revealed the great potential of polyphenols and flavonoids in human diet on protection against cancers, infections, their role in anti-aging and also against the development of several chronic diseases such as cardiovascular diseases (CVDs) or diabetes. Their role for human h
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7

Huber, Lisia Senger. "Flavinoides : identificação de fontes brasileiras e investigação dos fatores responsaveis pelas variações na composição." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256158.

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Orientador: Delia B. Rodriguez-Amaya<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-10T05:46:01Z (GMT). No. of bitstreams: 1 Huber_LisiaSenger_D.pdf: 841058 bytes, checksum: 9612feac8503fceabd312029260ed6cf (MD5) Previous issue date: 2007<br>Resumo: Devido a crescente importância atribuída aos flavonóides nos últimos anos, decorrente de suas ações relacionadas à prevenção de doenças degenerativas, e aliada à carência de dados destes compostos em alimentos brasileiros, este estudo teve como objetivo determin
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8

Bombonati, Aline Yashima. "Flavonois em frutas e hortaliças : efeito do co cozimento e microfiltração." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/322501.

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Orientador: Delia B. Rodriguez-Amaya<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-13T18:45:19Z (GMT). No. of bitstreams: 1 Bombonati_AlineYashima_M.pdf: 14727500 bytes, checksum: cb3e5718f8b66916dd2c522a99b17e51 (MD5) Previous issue date: 2009<br>Mestrado<br>Mestre em Ciência de Alimentos
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9

Eder, Christian. "Klonierung und Charakterisierung der Flavonoid 3'-Hydroxylase und der Flavonoid 3',5'-Hydroxylase." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963026275.

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10

Pap, N. (Nora). "Value-added processing of blackcurrants:use of membrane technologies for clarification and concentration of blackcurrant juice and extraction of anthocyanins from blackcurrant marc." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220840.

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Abstract Blackcurrants (Ribes nigrum L.) are widely consumed due to their favourable taste and health-promoting effects. The berries and extracts from different parts of the plant show anticarcinogenic, antioxidative and anti-inflammatory properties, and are effective in reducing the risk of cardiovascular disease and in promoting brain health. These health-promoting benefits are due to high concentrations of valuable compounds such as anthocyanins and flavonols in blackcurrants. However, these compounds are sensitive to heat and processing and some are lost when the berries are processed into
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11

Stewart, Amanda J. "Flavonoid occurrence, regulation in plant tissues and dietary contribution to health." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366202.

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12

Aziz, Azlina Abdul. "Investigations of the absorption and metabolism of antioxidant flavonols." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392950.

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13

Pourcel, Lucille. "Identification du gène TT10 codant une laccase : caractérisation de sa fonction dans l'oxydation des flavonoïdes de la graine chez Arabidopsis thaliana." Paris 11, 2006. http://www.theses.fr/2006PA112282.

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Deux classes de flavonoïdes sont présents dans les graines d’Arabidopsis thaliana : les procyanidines (PAs) ou tannins condensés résultant de la condensation de sous-unités flavane-3-ols (épicatéchines) et les flavonols. Ces composés phénoliques jouent un rôle important dans la qualité des semences et en santé humaine, en particulier de par leurs propriétés antioxydantes et antimicrobiennes. Bien que les étapes de la biosynthèse des flavonoïdes soient bien caractérisées, les mécanismes de polymérisation, oxydation et compartimentation des PAs restent inconnues. Chez Arabidopsis, le brunissemen
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14

Sanver, Didem. "Experimental modelling of flavonoid membrane interactions." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17383/.

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Flavonoids, a class of polyphenols, are commonly found in fruits, vegetables, nuts, and grains. Increasing evidence from epidemiological and clinical studies show a relationship between high flavonoid consumption in diet and reduced risk of several chronic diseases. Several mechanisms, including specific binding of flavonoids to proteins, have been proposed for flavonoids to exert their biological activities. However, it has also been reported that nonspecific interactions of flavonoids with phospholipids can induce structural changes in the membrane’s features (e.g., thickness and fluctuation
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15

Lemare, Rimlinger Nathalie. "Mise en évidence de synergies flavones-flavonols dans l'activité antivirale de la propolis." Rennes 1, 1995. http://www.theses.fr/1995REN1P022.

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16

Makris, Dimitrios. "Non-enzymic and enzymic degradation of flavonols in model systems." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246805.

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17

Barrington, Robert David. "The role of efflux transporters in the bioavailability of flavonols." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445524.

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18

Anderson, Stacey N. "Carbon Monoxide on Demand: Light-Induced CO Release of Flavonols." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7388.

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Carbon monoxide (CO) is an extremely useful molecule with applications in industrial manufacturing, synthetic procedures as a C1 building block, and as a potential pharmaceutical to produce anti-inflammatory effects and vasodilation. However, the toxicity associated with CO has prevented its full utilization. In order to safely handle CO, compounds and molecules have been developed that act as storage materials for the gas. Ideal storage platforms only release CO upon stimulation via a trigger. Light activation is the most desirable trigger as it can be regulated in terms of the intensity and
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19

Alkhalidy, Hana Awwad. "Flavonol kaempferol in the regulation of glucose homeostasis in diabetes." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82485.

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Diabetes mellitus is a major public health concern. Although the accessible novel drugs, techniques, and surgical intervention has improved the survival rate of individuals with diabetes, the prevalence of diabetes is still rising. Type 2 diabetes (T2D) is a result of chronic insulin resistance (IR) and loss of &beta;-cell mass and function. Therefore, the search for naturally occurring, low-cost, and safe compounds that could enhance insulin sensitivity and protect functional &beta;-cell mass can be an effective strategy to prevent this disease. Kaempferol, a flavonol present in various medic
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20

Sayre, Casey L. "Contribution of selected flavonoid enantiomers implicated in chronic disease prevention to differential pharmacokinetic and pharmacodynamic behaviour." Canadian Society for Pharmaceutical Sciences, 2013. http://hdl.handle.net/1993/30075.

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Decreases in risk of chronic disease associated with diets high in fruits and vegetables have been observed. Difficulty in determining the active ingredients responsible for the beneficial effects of dietary plant intake comes in part from the lack of pre-clinical pharmaceutical characterization of compounds thought to play a role. Flavonoids are a class of low molecular weight secondary metabolites present in plants. Pinocembrin, pinostrobin, and liquiritigenin are three chiral flavonoid implicated in the chronic disease prevention seen in high plant diets. To further the pre-clinical develop
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21

Cornish, Kelly Marie. "Dietary flavonoid quercetin in relation to cataract." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247104.

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22

Day, Andrea Jill. "Uptake and metabolism of dietary flavonoid glycosides." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327589.

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23

Caldwell, Stuart Thomas. "The synthesis of isotopically labelled flavonoid glucosides." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250932.

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24

Dana, Christopher David. "Structural Characterization of the Flavonoid Enzyme Complex." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/28356.

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Flavonoid biosynthesis is an important secondary metabolic pathway in higher plants with a range of vital functions in plants and animals. This pathway has been developed as a model system for the study of multi-enzyme complexes. The goal of the work presented here was to structurally characterize a series of loss-of-function chalcone synthase (CHS) alleles and to define the molecular basis of the interaction between CHS and the second enzyme of flavonoid biosynthesis, chalcone isomerase (CHI). CHS proteins encoded by five previously characterized alleles were characterized by homology mode
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25

Malbert, Yannick. "Flavonoid glucodiversification with engineered sucrose-active enzymes." Thesis, Toulouse, INSA, 2014. http://www.theses.fr/2014ISAT0038/document.

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Les flavonoïdes glycosylés sont des métabolites secondaires d’origine végétale, qui présentent de nombreuses propriétés physico-chimiques et biologiques intéressantes pour des applications industrielles. La glycosylation accroît généralement la solubilité de ces flavonoïdes mais leurs faibles niveaux de production dans les plantes limitent leur disponibilité. Ces travaux de thèse portent donc sur le développement de nouvelles voies de gluco-diversification des flavonoïdes naturels, en mettant à profit l’ingénierie des protéines. Deux transglucosylases recombinantes, structurellement et biochim
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26

Powell, Christopher. "The polyphenolic pigments of black tea." Thesis, University of Surrey, 1994. http://epubs.surrey.ac.uk/843227/.

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The polyphenolic pigments of black tea include the theaflavins (TF), the flavonol glycosides (FG) and a group of uncharacterised brown pigments referred to as thearubigins (TR). The TR are shown to be a complex, heterogeneous group of compounds, the majority of which are unresolvable by reverse phase HPLC. Fractionation procedures have been modified, developed, combined and applied to black tea liquor, to improve the separation of black tea components and to allow fractions of less complexity be obtained. A degree of resolution has been achieved for TR fractions, unresolvable with reverse phas
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27

Khaja, Sara. "Site-Directed Mutagenesis in Citrus paradisi Flavonol-Specific 3-O-Glucosyltransferase." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2453.

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Flavonoids are plant secondary metabolites that have significant biochemical and physiological roles. Biosynthesis of these compounds involves several modifications, most predominantly glucosylation, which is catalyzed by glucosyltransferases (GTs). A signature amino acid sequence, the PSPG box, is used to identify putative clones and has been shown to be involved in UDP-glucose binding. Site-directed mutagenesis is used to answer questions regarding the structure and function of this family of enzymes, particularly what allows some GTs to be more selective towards some substrates than others.
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28

Esquer, Heredia Hector Jose. "Toxicity and Mitochondrial Delivery of Flavonol-Based Carbon Monoxide-Releasing Molecules." DigitalCommons@USU, 2017. https://digitalcommons.usu.edu/etd/6882.

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Despite the reputation of carbon monoxide (CO) as a silent killer, new evidence suggests that this gaseous molecule has anti-inflammatory, anti-cancer and vasoprotective properties. Unfortunately, little is known about the role of CO in the body. However, proteins present in mitochondria are believed to be important targets. We previously synthesized a class of novel and structurally modifiable flavonol-based CO-releasing molecules (CORMs). Flavonols are commonly found in fruits and vegetables. The base structure, Flav-1, is fluorescent, exhibits low toxicity, and releases CO after exposure to
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29

Heigl, Dietmar. "Untersuchungen zur Stabilität von flavonoid- und gerbstoffhaltigen Drogen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968310184.

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30

Fink, Brian N. Gammon Marilie D. "Flavonoid intake and breast cancer incidence and survival." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,1280.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.
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31

Fourie, Petrus Michiel. "Neuroprotective effects of amantadine–flavonoid conjugates / Fourie P.M." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7339.

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Neurodegenerative disorders like Parkinson’s and Alzheimer’s disease affect millions of people around the world. Oxidative stress has been implicated in the pathogenesis of a number of neurodegenerative disorders, cancer and ischemia. The brain is particularly vulnerable to oxidative damage because of its high utilisation of oxygen, high levels of polyunsaturated fatty acids, relatively high levels of redox transition metal ions and low levels of antioxidants. Oxidative stress occurs due to an imbalance in the pro–oxidant and antioxidant levels. Reactive oxygen/nitrogen species (ROS/RNS) is a
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32

Burbulis, Ian E. "Macromolecular organization of flavonoid biosynthesis in Arabidopsis thaliana." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/26023.

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Living cells manufacture and degrade thousands of chemical compounds in vivo. To do this cells rely on the activities of thousands of different protein catalysts distributed in aqueous interior compartments. Over the past several decades studies have shown that the thermodynamic and kinetic properties of most proteins, including enzymes, are different in vivo as compared to in vitro. Based on in vitro studies metabolic pathways have traditionally been thought to consist of intermediates randomly diffusing between soluble enzymes and are still portrayed as such in many biochemistry textbooks. A
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33

Santos, Michael Carmelo Orda. "Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27349.

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In an effort to test the feasibility of intracellular expression of enzyme-targeted antibodies to alter metabolism, recombinant antibody fragments in the single-chain format (scFv) were isolated from a phage display library using Arabidopsis chalcone isomerase (CHI) of the flavonoid biosynthetic pathway as the antigen. Each of the genes encoding the scFvâ s was cloned into a plant transformation vector, which was subsequently used to generate transgenic plants. One transgenic line with low expression of one of the scFvâ s appeared to have an altered flavonoid metabolism, as evidenced by a
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34

Liou, Geoffrey. "Enzyme structure, function, and evolution in flavonoid biosynthesis." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122067.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Plant specialized metabolism is a key evolutionary adaptation that has enabled plants to migrate from water onto land and subsequently spread throughout terrestrial environments. Flavonoids are one particularly important class of plant specialized metabolites, playi
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35

Koupai-Abyazani, Mohammed R. "Analytical methods for the identification of biologically active flavonoids." Thesis, University of East Anglia, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280027.

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36

Sitthiphong, Piyawan. "Impact of flavonoid-rich and flavonoid-poor fruit and vegetables on biomarkers of cancer risk in a human randomized controlled trial." Thesis, University of Reading, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602467.

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Epidemiological studies have shown an association between fruit and vegetable (F&V) consumption and decreased risk of cancer at several sites. However, there are few human intervention studies that provide information about a causal link between F&V consumption and cancer risk and about the optimum amounts of F&V that need to be consumed and whether some types of F&V are more effective than others. This study aims to investigate the impact of increasing intake of flavonoid-rich and flavonoid-poor F&V in human subjects on three endpoints: lymphocyte DNA damage, inflammation markers and gene exp
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37

Birchfield, Aaron, and Cecelia A. McIntosh. "Crystallization of a Flavonol-Specific 3-O-Glucosyltrasnferase found in Citrus paradisi." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/365.

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Citrus and other fruits produce secondary metabolites that are synthesized, regulated, and modified in part by a class of enzymes called glycosyltransferases. This class of enzymes is of substantial interest to this lab due to their unique structural and functional properties. Glycosides of flavonoids produced by glycosyltransferases have emerged in recent years as a critical part of plant metabolism, thus impacting every aspect of their growth, cultivation, production, and utilization. One such glycosyltransferase, found in Duncan Grapefruits (Citrus paradisi), was previously identified, reco
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38

Devaiah, Shivakumar P., and Cecelia A. McIntosh. "Site-Directed Mutational Analysis of Flavonol 3-0-Glucosyltransferases from Citrus paradisi." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/340.

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Glucosyltransferases (GTs) are the important group of enzymes which facilitates the incorporation of UDPactivated glucose to a corresponding acceptor molecule through glucosylation. Glucosylation is a common alteration reaction in plant metabolism and is regularly associated with the production of secondary metabolites. Glucosylation serves a number of roles within metabolism including: stabilizing structures, affecting solubility, transport, and regulating the bioavailability of the compounds for other metabolic processes. GTs involved in secondary metabolism share a conserved 44 amino acid r
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39

Behm, Norma. "Einfluss des Flavonols Quercetin auf ausgewählte Parameter des Energiestoffwechsels bei fettreich ernährten Ratten." Tönning Lübeck Marburg Der Andere Verl, 2009. http://d-nb.info/997031263/04.

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40

Ghidouche, Souhila. "Produits d’oxydation de flavonols et de flavanols par la laccase de Trametes versicolors." Rennes, Agrocampus Ouest, 2008. http://www.theses.fr/2008NSARB187.

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Les flavonols et les flavan-3ols représentent deux sous classes importantes tant pour les végétaux que pour les humains. Ces propriétés sont toutefois affectées par les phénomènes d’oxydation enzymatique. Les laccases constituent un des principaux groupes d’enzymes impliqués dans ces réactions. Peu d’études se sont intéressées aux mécanismes précis de ces oxydations ainsi qu’aux structures des produits obtenus. Le but de cette étude est de déterminer les structures des produits d'oxydation des flavonols et des flavan-3ols par la lacasse de Trametes versicolor et de comparer leurs mécanismes de
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41

Jin, Xin. "Isoprenoid and flavonoid biosynthesis and regulation in higher plants." Doctoral thesis, Universitat de Lleida, 2019. http://hdl.handle.net/10803/667579.

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Aquesta tesi es centra principalment en l'anàlisi funcional i la caracterització dels gens que codifiquen per a alguns metabòlits secundaris i en l’estudi de la seva regulació en les plantes. Els objectius generals varen ser (a) entendre millor la regulació transcripcional del gen de la biosíntesi dels carotenoids, la β-carotè hidroxilasa 2 (BCH2) en el blat de moro i (b) l'anàlisi funcional de les dues isopentenil difosfat isomerasas (OsIPPI) d'arròs i determinar la seva localització subcel·lular. Simultàniament, es va estudiar com la llum afecta la via metabòlica i a la producció de pelargon
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42

Jaakola, L. (Laura). "Flavonoid biosynthesis in bilberry (Vaccinium myrtillus L.)." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271599.

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Abstract Flavonoids are a class of secondary metabolites in plants that are involved in many important functions. Various flavonoid compounds have also been reported to be beneficial for human health. Bilberry (Vaccinium myrtillus L.) is the characteristic field layer species in boreal forests and the fruits of bilberry are rich in anthocyanin pigments, a subclass of flavonoids. In the present work, flavonoid biosynthesis was examined in different tissues of bilberry. The focus was on the developing fruits of wild type and natural color mutants of bilberry, and on effect of solar radiation on
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43

Wong, Chi Chun. "Metabolism and transport of flavonoid and hydroxycinnamic acid conjugates." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545723.

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44

Schroeter, Hagen. "Oxidative stress and neuronal dysfunction : mechanisms of flavonoid protection." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396046.

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45

Pereira, Ana Bárbara Ferreira Neves Quatorze. "Flavonoid-cyclodextrin complexes and their incorporation in milk products." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15325.

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Mestrado em Bioquímica - Bioquímica Alimentar<br>The presented work describes the inclusion of the flavonoid quercetin into β and γ cyclodextrins and the subsequent incorporation of such complexes into a dairy product — fresh cheese. The characterization of the complexes was made using various techniques, and antioxidant assays were also performed to assess their antioxidant and anti-lipid peroxidation capacity in comparison to quercetin. The incorporation of the complexes in fresh cheese resulted in the modification of some of the characteristics of the food product, having these also present
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46

Watjen, W., A.-K. Suckow-Schnitker, R. Rohrig, et al. "Prenylated flavonoid derivatives from the bark of Erythrina addisoniae." American Chemical Society, 2008. http://hdl.handle.net/10454/4532.

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no<br>Two new prenylated flavanones, 2S-3¿-(2-hydroxy-3-methylbut-3-enyl)licoflavone-4¿-methyl ether (3) and 2S-3¿-(2- hydroxy-3-methylbut-3-enyl)abyssinone II (4), and four known flavanones (1, 2, 5, 6) were isolated from the stem bark of Erythrina addisoniae. The structures were elucidated on the basis of their spectroscopic and physicochemical data. None of the compounds showed antioxidative properties. 4¿-Methylabyssinone V (1) and abyssinoflavanone VII (6) showed moderate cytotoxic activity (IC50 ) 5 and 3.5 ¿mol/L, respectively), but apoptosis (caspase-3/7-activation, nuclear fragme
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47

King, Kathleen. "The Effect of R382W Mutation on Citrus paradisi Flavonol Specific 3-O-Glucosyltransferase." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/honors/355.

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Flavonoids are a class of plant metabolites with C6-C3-C6 structure responsible for many biological functions, including coloration and defense. Citrus paradisi, grapefruit, contains a wide variety of flavonoids which are grouped by the extent of modification, examples of which are flavonols, flavones, and flavanones. A major modification is the addition of glucose by glucosyltransferases (GTs) to stabilize the structure and provide ease of transport. Glucosyltransferases can be highly substrate and regiospecific. With Cp3OGT, glucose is added at the 3-hydroxy position. This 3GT only accepts f
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48

Carter, Lisa, Devaiah P. Shivakumar, and Cecelia A. McIntosh. "Mutagenesis of a Flavonol- 3-O-Glucosyltransferase and the Effect on Enzyme Function." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/349.

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Flavonoids are an important group of secondary metabolites found in plants and have a wide variety of properties. Some play a role in fl ower pigmentation, while others have antimicrobial properties. Glucosylation is an important modifi cation of fl avonoids and is mediated by glucosyltransferases. In this process, the enzyme transfers glucose from UDP-glucose to a specifi c position on the fl avonoid. Previous study from the lab characterized a glucosyltransferase from C. paradisi that is fl avonol specifi c. In this study an attempt has been made to study the structure and function of this f
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49

Devaiah, Shivakumar P., and Cecelia A. McIntosh. "Substrate Specificity and Kinetic Properties of Flavonol-3-O-Glucosyltransferase From Citrus Paradisi." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/342.

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Glucosyltransferases (GTs) are enzymes that expedite the incorporation of UDP-activated glucose to a corresponding acceptor molecule. This enzymatic reaction stabilizes structures and affects solubility, transport, and bioavailability of flavonoids for other metabolic processes. Flavonoid glycosides affect taste characteristics in citrus making the associated glucosyltransferases particularly interesting targets for biotechnology applications. Custom design of enzymes requires understanding of structure/function of the protein. The present study focuses on creating mutant flavonol-3-O-glucosyl
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50

King, Kathleen, Devaiah P. Shivakumar, and Cecelia A. McIntosh. "The Effect of R382W Mutation on C. paradisi Flavonol-Specific 3-O-Glucosyltransferase." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/358.

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Flavonoids are a class of plant metabolites with C6-C3-C6 structure responsible for many biological functions, including coloration and defense. Citrus paradisi, grapefruit, contains a wide variety of flavonoids which are grouped by the extent of modification, examples of which are flavonols, flavones, and flavanones. A major modification is the addition of glucose by glucosyltransferases (GTs) to stabilize the structure and provide ease of transport. This process can be highly substrate and regiospecific. With Cp3OGT, glucose is added at the 3-hydroxy position. This 3GT only accepts flavonols
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