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1

Marchi, D., D. Lanati, G. Mazza, and P. Cascio. "Composizione in antociani e flavonoli di vini prodotti nel territorio svizzero." BIO Web of Conferences 15 (2019): 02012. http://dx.doi.org/10.1051/bioconf/20191502012.

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In questa nota sono presentati i risultati delle determinazioni del profilo degli antociani e dei flavonoli di vini prodotti con uve di alcune varietà a frutto colorato prodotte a Nord della Svizzera, nel cantone di Schaffhausen , nella regione di Klettgau. I vini sono stati ottenuti da uve delle varietà di Vitis vinifera Cabernet Dorsa, Gamaret, Dornfelder, Acolon e di un incrocio interspecifico Sylvaner × Müller Thurgau × Chambourcin (Regent). Il profilo degli antociani dei vini delle varietà di Vitis vinifera studiate è risultato a netta prevalenza di molecole trisostituite all'anello later
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2

Marchi, D., D. Lanati, P. Cascio, and M. Giacomo. "Influenza della sfogliatura sulla sintesi della quercetina in Sangiovese. Ulteriori acquisizioni sui precipitati di quercetina nei vini." BIO Web of Conferences 15 (2019): 02010. http://dx.doi.org/10.1051/bioconf/20191502010.

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Allo scopo di approfondire i fattori che portano ad un accumulo elevato dei flavonoli e in particolare dei glicosidi della quercetina nell'uva abbiamo valutato in campo l'influenza della defogliazione precoce e all'invaiatura e di altre variabili viticole sulla sintesi di questi composti. Nello stesso tempo abbiamo studiato l'influenza della refrigerazione del vino e della formazione di complessi con altre sostanze presenti nel vino sulla solubilità della quercetina aglicone. I risultati ottenuti hanno confermato che: i) la defogliazione, in particolare quella precoce, inducono un incremento d
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3

Lewis, David, Marie Bradley, Stephen Bloor, et al. "Altering expression of the flavonoid 3′-hydroxylase gene modified flavonol ratios and pollen germination in transgenic Mitchell petunia plants." Functional Plant Biology 33, no. 12 (2006): 1141. http://dx.doi.org/10.1071/fp06181.

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Antisense technology was successfully used to reduce flavonoid 3′-hydroxylase (F3′H) gene expression and enzyme activity and to promote the accumulation of monohydroxylated flavonols in petunia flower tissue. The hydroxylation pattern of specific flavonoid groups is a target for modification because of the possible associated changes in a range of factors including colour, stress tolerance and reproductive viability. Petunia (cv. Mitchell) plants were transformed to express in the antisense orientation the sequences encoding the F3′H (asF3′H). Transformants showed a range of responses, in term
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4

Joshi, Kunjani. "Leaf Flavonoid Patterns in the Species of Stemonoporus (Dipterocarpaceae) and Their Taxonomic Significance." Journal of Natural History Museum 24 (October 9, 2009): 146–55. http://dx.doi.org/10.3126/jnhm.v24i1.2291.

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During the chemotaxonomic study of 16 species of Stemonoporus, three flavonoid aglycones (flavonol quercetin, flavonol kaempferol and flavone apigenin) and glycosides (quercetin 3- glucoside, quercetin 3-rutinoside and apigenin 5-glucoside) were isolated while flavonol myricetin, flavone luteolin and proanthcyanidin were not detected in any of the species surveyed. The isolated flavonoids can be used as chemotaxonomic markers. The species of Stemonoporus can be regarded as advanced in flavonoid pattern because of the absence of myricetin and loss of proanthocyanidins. The data of the flavonoid
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5

Șandru, Daniela. "Identification and quantification of valuable phenolic compounds from red wines from western part of Romania." World Journal of Advanced Research and Reviews 2, no. 1 (2019): 028–33. https://doi.org/10.5281/zenodo.4308844.

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The aim of this paper is to identify and quantify different phenolic compounds known and appreciated for their antioxidant action from five red wines from the west side of Romania.  For the determinations HPLC methods were used, the samples were done in cycles of three for better results. Phenolic acids that drew the attention have different values that ranging from 1.3007 mg/L (elagic acid) to 19.3315 (t-cafftaric acid), some various flavonoids (flavone, flavonoli și flavanoli) the values of which were recorded between 0.9997 mg/L (apigenin) and 56.1617 mg/L (catechin) and the stilbens n
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6

Ivey, Kerry L., Joshua R. Lewis, Richard L. Prince, and Jonathan M. Hodgson. "Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women." British Journal of Nutrition 110, no. 9 (2013): 1648–55. http://dx.doi.org/10.1017/s0007114513000780.

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Epidemiological studies have indicated that dietary flavonoids generally, and flavonols specifically, may contribute to cardiovascular health. Tea consumption, which is often the main dietary source of flavonoids and flavonols, is associated with a reduced risk of cardiovascular outcomes. The primary objective of the present study was to explore the association of the habitual intake of flavonols from tea and non-tea sources with the risk of atherosclerotic vascular disease mortality in a population of elderly women. A total of 1063 women, aged over 75 years, were randomly selected from ambula
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7

Kempf, Karl, Oxana Kempf, Yoan Capello, et al. "Synthesis of Flavonol-Bearing Probes for Chemoproteomic and Bioinformatic Analyses of Asteraceae Petals in Search of Novel Flavonoid Enzymes." International Journal of Molecular Sciences 24, no. 11 (2023): 9724. http://dx.doi.org/10.3390/ijms24119724.

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This study aimed at searching for the enzymes that are responsible for the higher hydroxylation of flavonols serving as UV-honey guides for pollinating insects on the petals of Asteraceae flowers. To achieve this aim, an affinity-based chemical proteomic approach was developed by relying on the use of quercetin-bearing biotinylated probes, which were thus designed and synthesized to selectively and covalently capture relevant flavonoid enzymes. Proteomic and bioinformatic analyses of proteins captured from petal microsomes of two Asteraceae species (Rudbeckia hirta and Tagetes erecta) revealed
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8

Maslov Bandić, Luna, Milena Jenić, and Boris Duralija. "Bioaktivni spojevi u plodu, listu i sjemenci maline (Rubus idaeus L.)." Glasnik zaštite bilja 43, no. 5 (2020): 50–55. http://dx.doi.org/10.31727/gzb.43.5.6.

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Malina (Rubus idaeus L.) jedna je od voćnih vrsta koje su bogate raznolikim kemijskim spojevima kao što su vitamini, minerali i polifenoli. Polifenoli utječu na senzorna i nutritivna svojstva biljke. Listovi i sjemenke maline, koje su većinom nusprodukt proizvodnje imaju značajan sadržaj polifenola, te bi se zajedno s plodovima mogli više koristiti u ljudskoj prehrani kao alternativni izvor bioaktivnih spojeva. U ovom radu određivani su polifenolni spojevi, te je utvrđen sadržaj flavonoida, antocijana i ukupnih fenola u plodu, sjemenci i listu maline sorte 'Himbo Top'. Najveći maseni udio poli
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9

Lumbessy, Mirna, Jemmy Abidjulu, and Jessy J. E. Paendong. "Uji Total Flavonoid Pada Beberapa Tanaman Obat Tradisonal Di Desa Waitina Kecamatan Mangoli Timur Kabupaten Kepulauan Sula Provinsi Maluku Utara." Jurnal MIPA 2, no. 1 (2013): 50. http://dx.doi.org/10.35799/jm.2.1.2013.766.

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Penelitian ini bertujuan untuk menguji total kandungan flavonoid pada beberapa tanaman obat tradisional. Penentuan kandungan total flavonoid dilakukan dengan menggunakan metode etanol – HCl, sedangkan analisis flavonoid menggunakan Metode spektrofotometeyr UV-VIS . Hasil yang diperoleh menunjukan kandungan total flavonoid pada tanaman ketepeng cina (Cassia alata L) sebesar 26.8633 mg/mL , iler (Coleus scutellariodes L Benth) sebesar 14.425 mg/mL , rumput teki (Cyperus rotundus L) sebesar 6.505 mg/mL, pegagan (Centella asiatica) sebesar 3.816 mg/mL, rumput mutiara (Oldenlandia corymbosa) sebesa
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10

Satheesh Kumar D, Shailendra Kumar, and Ravichandran S. "In vitro antidiabetic evaluation of nanoparticles encompass dual bioflavonoid." International Journal of Research in Phytochemistry and Pharmacology 8, no. 1 (2020): 1–6. http://dx.doi.org/10.26452/ijrpp.v8i1.1224.

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The flavonoids which are widely spread in plants. It can be categorized as flavonols, flavonols, flavanones, flavones, anthocyanidin and isoflavones. Apigenin and Hesperidin account these three flavonoids used a significant proportion of flavonol intake in the diet as a functional food. Among all other flavonoids, Apigenin has many health cares and disease-prevention benefits. Polymer-based formulations, such as nanoemulsions and solid lipid nanoparticles, have been developed to increase the therapeutic efficacy of flavonoids. New drug delivery systems such as Dual Loaded Flavono Nanoparticula
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11

Li, Zhiliang, Siduo Xu, Hongmei Wu, et al. "Integrated Analyses of Metabolome and RNA-seq Data Revealing Flower Color Variation in Ornamental Rhododendron simsii Planchon." Genes 15, no. 8 (2024): 1041. http://dx.doi.org/10.3390/genes15081041.

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Rhododendron simsii Planchon is an important ornamental species in the northern hemisphere. Flower color is an important objective of Rhododendron breeding programs. However, information on anthocyanin synthesis in R. simsii is limited. In this research, the regulatory mechanism of anthocyanin biosynthesis in R. simsii was performed through the integrated analysis of metabolome and RNA-seq. A total of 805 and 513 metabolites were screened by positive and negative ionization modes, respectively, In total, 79 flavonoids contained seven anthocyanidins, 42 flavanones, 10 flavans, 13 flavones, and
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12

Zhao, Qun, Zheng Wang, Gaiping Wang, et al. "Effects of UVA on Flavonol Accumulation in Ginkgo biloba." Forests 15, no. 6 (2024): 909. http://dx.doi.org/10.3390/f15060909.

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Ginkgo is an economic tree species with high medicinal value, and flavonols are its main medicinal components. This research was conducted to investigate the molecular mechanism underlying the influence of Ultraviolet A (UVA) treatment on the synthesis of ginkgo flavonols with the aim of increasing their content. Ginkgo full-sib hybrid offspring were used as test materials. The phenylalanine ammonialyase (PAL), cinnamate 4-hydroxylase (C4H), and 4-coumarate: CoA ligase (4CL) enzyme activities, as well as flavonol contents, were measured under the same intensity of white light (300 μmol·m−2·s−1
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13

Sun, Caihong, Hui Wang, Dong Wang, Yanping Chen, Yan Zhao, and Wei Xia. "Using an FFQ to assess intakes of dietary flavonols and flavones among female adolescents in the Suihua area of northern China." Public Health Nutrition 18, no. 4 (2014): 632–39. http://dx.doi.org/10.1017/s1368980014000780.

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AbstractObjectiveThe present study aimed to (i) evaluate the reproducibility and validity of a designed FFQ, (ii) apply the FFQ for estimating the dietary intakes of four flavonols and two flavones in female adolescents and (iii) explain their major dietary sources.DesignThe reproducibility between the first and second FFQ administrations (1 year interval) was estimated using the intra-class correlation coefficient. The validity of the first FFQ relative to the average of four three-day 24 h dietary recalls (24-HR) from four seasons was assessed using the Spearman correlation coefficient. Usin
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14

Nikolova, M., and S. Ivancheva. "Distribution of Surface Flavonoids in Bulgarian Plants." Natural Product Communications 1, no. 11 (2006): 1934578X0600101. http://dx.doi.org/10.1177/1934578x0600101119.

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The review describes the distribution of surface flavonoids in Bulgarian plants. More than 100 species of Asteraceae, Lamiaceae, Scrophulariaceae, Geraniaceae and other families have been checked for external flavonoid aglycones. The flavonoid profiles of Asteraceae species are composed of a wide array of flavones and flavonols, mainly based upon 6-substituted derivatives. Flavone aglycones are predominant in the exudates of Lamiaceae species. Apigenin, luteolin and their derivatives were most commonly found in the studied species of Scropulariaceae and Lamiaceae. It has been shown that specie
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15

Wang, Lanxiang, Pui Ying Lam, Andy C. W. Lui, et al. "Flavonoids are indispensable for complete male fertility in rice." Journal of Experimental Botany 71, no. 16 (2020): 4715–28. http://dx.doi.org/10.1093/jxb/eraa204.

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Abstract Flavonoids are essential for male fertility in some but not all plant species. In rice (Oryza sativa), the chalcone synthase mutant oschs1 produces flavonoid-depleted pollen and is male sterile. The mutant pollen grains are viable with normal structure, but they display reduced germination rate and pollen-tube length. Analysis of oschs1/+ heterozygous lines shows that pollen flavonoid deposition is a paternal effect and fertility is independent of the haploid genotypes (OsCHS1 or oschs1). To understand which classes of flavonoids are involved in male fertility, we conducted detailed a
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16

Kyle, Janet A. M., Linda Sharp, Julian Little, Garry G. Duthie, and Geraldine McNeill. "Dietary flavonoid intake and colorectal cancer: a case–control study." British Journal of Nutrition 103, no. 3 (2009): 429–36. http://dx.doi.org/10.1017/s0007114509991784.

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Diets rich in flavonoids may reduce the risk of developing colorectal cancer. Flavonoids are widely distributed in foods of plant origin, though in the UK tea is the main dietary source. Our objective was to evaluate any independent associations of total dietary and non-tea intake of four flavonoid subclasses and the risk of developing colorectal cancer in a tea-drinking population with a high colorectal cancer incidence. A population-based case–control study (264 cases with histologically confirmed incident colorectal cancer and 408 controls) was carried out. Dietary data gathered by FFQ were
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17

Chen, Xiaoshan, Ying Wu, Zhanghong Yu, et al. "BcMYB111 Responds to BcCBF2 and Induces Flavonol Biosynthesis to Enhance Tolerance under Cold Stress in Non-Heading Chinese Cabbage." International Journal of Molecular Sciences 24, no. 10 (2023): 8670. http://dx.doi.org/10.3390/ijms24108670.

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Flavonols have been shown to respond to a variety of abiotic stresses in plants, including cold stress. Higher total flavonoid content was found in non-heading Chinese cabbage (NHCC, Brassica campestris (syn. Brassica rapa) ssp. chinensis) after cold stress. A non-targeted metabolome analysis showed a significant increase in flavonol content, including that of quercetin and kaempferol. Here, we found that an R2R3–MYB transcription factor, BcMYB111, may play a role in this process. BcMYB111 was up-regulated in response to cold treatment, with an accompanying accumulation of flavonols. Then, it
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18

Wang, Qianchao, Lan Yao, Qunying Li, et al. "Integrative Analysis of the Metabolome and Transcriptome Provides Insights into the Mechanisms of Flavonoid Biosynthesis in Quinoa Seeds at Different Developmental Stages." Metabolites 12, no. 10 (2022): 887. http://dx.doi.org/10.3390/metabo12100887.

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Quinoa (Chenopodium quinoa Willd.) is a crop with high nutritional and health benefits. Quinoa seeds are rich in flavonoid compounds; however, the mechanisms behind quinoa flavonoid biosynthesis remain unclear. We independently selected the high-generation quinoa strain ‘Dianli-3260′, and used its seeds at the filling, milk ripening, wax ripening, and mature stages for extensive targeted metabolome analysis combined with joint transcriptome analysis. The results showed that the molecular mechanism of flavonoid biosynthesis in quinoa seeds was mainly concentrated in two pathways: “flavonoid bio
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19

Dewi, Ni Wayan Rika Kumara, I. Wayan Gunawan, and Ni Made Puspawati. "ISOLASI DAN IDENTIFIKASI SENYAWA ANTIOKSIDAN GOLONGAN FLAVONOID DARI EKSTRAK ETIL ASETAT DAUN PRANAJIWA (Euchresta horsfieldii Lesch Benn.)." CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) 5, no. 1 (2017): 26. http://dx.doi.org/10.24843/ck.2017.v05.i01.p04.

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ABSTRAK: Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan mengidentifikasi senyawa golongan flavonoid yang terkandung dalam ekstrak etil asetat daun pranajiwa (Euchresta horsfieldii Lesch Benn.). Uji aktivitas antioksidan dilakukan secara invitro dengan metode DPPH (1,1-diphenyl-2-pycrylhidrazyl). Teknik pemisahan dilakukan dengan kromatografi kolom dan diidentifikasi dengan spektrofotometer FTIR dan UV-Vis. Hasil penelitian menunjukkan bahwa ekstrak etil asetat memiliki aktivitas antioksidan dengan nilai IC50 sebesar 393,95 µg/mL dan kadar total flavonoid sebesar 6619,72 mg
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20

Johnson, Emanuel L., and Walter F. Schmidt. "Flavonoids as Chemotaxonomic Markers for Erythroxylum ulei." Zeitschrift für Naturforschung C 54, no. 11 (1999): 881–88. http://dx.doi.org/10.1515/znc-1999-1105.

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Abstract Leaf extracts of Erythroxylum ulei O. E. Schulz, produced six O-conjugated flavonoids. Three of the flavonoid aglycones were isoflavones, two were isoflavanones and the remainder a flavonol (quercetin). The major glycosides of these flavonols included mono-and dirham-nosides, mono-glucosides and galactosides with either 3̕ 4̕, or 7 linkage or a combination thereof. The two isoflavanones, in addition to being glycosylated, possessed a methyl group at position 2 of the C-ring. These flavonoids may be used as chemotaxonomic markers for the taxon.
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21

Dangrit, Darin, and Kanokporn Sompornpailin. "Enhancing Biosynthesis of Flavonol Protective Biomaterials Using FLS Transgenic Plants." Applied Mechanics and Materials 866 (June 2017): 29–32. http://dx.doi.org/10.4028/www.scientific.net/amm.866.29.

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Flavonol synthase (FLS) gene encodes an enzyme that is involved in conversion substrates into flavonols, quercetin and kaempferol. These substances are a subgroup of flavonoids which have an important role in both plant and human health. Many environmental factors such as temperature, pH and UV-A radiation have been studied and presented relationship with flavonoid synthesis. In this experiment, the combination of visible and UV-A lights was used as factors for elevating flavonoid biosynthesis of wild type (WT) plant and two lines of FLS transgenic plant under tissue culture condition. Both tr
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22

Kozłowska, Aleksandra, and Dorota Szostak-Węgierek. "Targeting Cardiovascular Diseases by Flavonols: An Update." Nutrients 14, no. 7 (2022): 1439. http://dx.doi.org/10.3390/nu14071439.

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Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, random
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23

Ma, Bin, Yan Song, Xinghua Feng, et al. "Integrated Metabolome and Transcriptome Analyses Reveal the Mechanisms Regulating Flavonoid Biosynthesis in Blueberry Leaves under Salt Stress." Horticulturae 10, no. 10 (2024): 1084. http://dx.doi.org/10.3390/horticulturae10101084.

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The flavonoids play important roles in plant salt tolerance. Blueberries (Vaccinium spp.) are extremely sensitive to soil salt increases. Therefore, improving the salt resistance of blueberries by increasing the flavonoid content is crucial for the development of the blueberry industry. To explore the underlying molecular mechanism, we performed an integrated analysis of the metabolome and transcriptome of blueberry leaves under salt stress. We identified 525 differentially accumulated metabolites (DAMs) under salt stress vs. control treatment, primarily including members of the flavonoid clas
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24

Yang, Ming-hua, and Ling-yi Kong. "Flavonols and flavonol glycosides from Rhododendron irroratum." Chemistry of Natural Compounds 44, no. 1 (2008): 98–99. http://dx.doi.org/10.1007/s10600-008-0028-6.

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Zhang, Haiwen, Huihui Tao, Hao Yang, et al. "MdSCL8 as a Negative Regulator Participates in ALA-Induced FLS1 to Promote Flavonol Accumulation in Apples." International Journal of Molecular Sciences 23, no. 4 (2022): 2033. http://dx.doi.org/10.3390/ijms23042033.

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Apples (Malus domestica) are rich in flavonols, and 5-aminolevulinic acid (ALA) plays an important role in the regulation of plant flavonoid metabolism. To date, the underlying mechanism of ALA promoting flavonol accumulation is unclear. Flavonol synthase (FLS) is a key enzyme in flavonol biosynthesis. In this study, we found that ALA could enhance the promoter activity of MdFLS1 in the ‘Fuji’ apple and improve its expression. With MdFLS1 as bait, we screened a novel transcription factor MdSCL8 by the Yeast One-Hybrid (Y1H) system from the apple cDNA library which we previously constructed. Us
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Valant-Vetschera, Karin M., and Eckhard Wollenweber. "Chemodiversity of Exudate Flavonoids in Seven Tribes of Cichorioideae and Asteroideae (Asteraceae)." Zeitschrift für Naturforschung C 62, no. 3-4 (2007): 155–63. http://dx.doi.org/10.1515/znc-2007-3-401.

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Abstract Members of several genera of Asteraceae, belonging to the tribes Mutisieae, Cardueae, Lactuceae (all subfamily Cichorioideae), and of Astereae, Senecioneae, Helenieae and Heliantheae (all subfamily Asteroideae) have been analyzed for chemodiversity of their exudate flavonoid profiles. The majority of structures found were flavones and flavonols, sometimes with 6- and/or 8-substitution, and with a varying degree of oxidation and methylation. Flavanones were observed in exudates of some genera, and, in some cases, also flavonol- and flavone glycosides were detected. This was mostly the
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Karapandzova, Marija, Gjose Stefkov, Ivana Cvetkovikj, Jasmina Petreska Stanoeva, Marina Stefova, and Svetlana Kulevanova. "Flavonoids and Other Phenolic Compounds in Needles of Pinus peuce and Other Pine Species from the Macedonian Flora." Natural Product Communications 10, no. 6 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000647.

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Flavonoids and other phenolic compounds in young needles of four pine species, Pinus peuce, P. nigra, P. mugo and P. sylvestris from the Macedonian flora were investigated. The amount of total phenols and total flavonoids were determined using Folin-Ciocalteau and aluminum chloride assay, respectively. The obtained results revealed that the total phenolic content (TPC) and total flavonoids content (TFC) varied among different pine species ranging from 9.8 to 14.0 mg GAE/g and from 3.3 to 7.2 mg CE/g of dried plant material, respectively. Qualitative analysis of flavonoids and other phenolic co
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28

Zhou, Yanjun, Ke Gu, and Fengying Zhou. "Dietary Flavonoid Intake and Cancer Mortality: A Population-Based Cohort Study." Nutrients 15, no. 4 (2023): 976. http://dx.doi.org/10.3390/nu15040976.

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Cancer is a leading cause of death worldwide, posing a huge burden upon society and individuals. The adequate intake of fruit and vegetables is reported to be an effective strategy for primary cancer prevention. Fruits and vegetables are rich in nutrients, such as vitamins and flavonoids, which may reduce the occurrence and progression of cancers. However, the importance of each flavonoid and the sub-classes remains controversial regarding cancer mortality. The population benefiting from increased flavonoid intake has not been determined. An estimation of cancer mortality by flavonoid intake i
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Gao, Gang, Ping Chen, Jikang Chen, et al. "Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways." Metabolites 9, no. 12 (2019): 296. http://dx.doi.org/10.3390/metabo9120296.

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Apocynum plants, especially A. venetum and A. hendersonii, are rich in flavonoids. In the present study, a whole genome survey of the two species was initially carried out to optimize the flavonoid biosynthesis-correlated gene mining. Then, the metabolome and transcriptome analyses were combined to elucidate the flavonoid biosynthesis pathways. Both species have small genome sizes of 232.80 Mb (A. venetum) and 233.74 Mb (A. hendersonii) and showed similar metabolite profiles with flavonols being the main differentiated flavonoids between the two specie. Positive correlation of gene expression
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30

Guo, Xiaozhu, Gui Wang, Juan Li, Jiang Li, and Xuemei Sun. "Analysis of Floral Color Differences between Different Ecological Conditions of Clematis tangutica (Maxim.) Korsh." Molecules 28, no. 1 (2023): 462. http://dx.doi.org/10.3390/molecules28010462.

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The Clematis tangutica (Maxim.) Korsh. is a wild flowering plant that is most widely distributed on the Qinghai–Tibet Plateau, with beautiful, brightly colored flowers and good ornamental properties and adaptability. In diverse natural environments, the blossom color of C. tangutica (Maxim.) Korsh. varies greatly, although it is unclear what causes this diversity. It was examined using UPLC-MS/MS and transcriptome sequencing for the investigation of various compounds, differentially expressed genes (DEGs), and flavonoid biosynthesis-related pathways in two flowers in two ecological settings. T
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Stich, K., T. Eidenberger, F. Wurst, and G. Forkmann. "Flavonol Synthase Activity and the Regulation of Flavonol and Anthocyanin Biosynthesis during Flower Development in Dianthus caryophyllus L. (Carnation)." Zeitschrift für Naturforschung C 47, no. 7-8 (1992): 553–60. http://dx.doi.org/10.1515/znc-1992-7-811.

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Flavonol synthase (FLS) was demonstrated in crude extracts from flower buds of Dianthus caryophyllus (carnation). The enzyme catalyzed the conversion of dihydrokaempferol and ihydroquercetin to kaempferol and quercetin, respectively. The reaction required 2-oxoglutarate, ferrous ion and ascorbate as co-factors and had a pH optimum at about 7.4. The demonstration of FLS activity allowed comparative studies on flavonol and anthocyanin biosynthesis during bud and flower development. Besides FLS the flavonoid enzymes chalcone synthase (CHS), flavanone 3-hydroxylase (FH T) and dihydroflavonol 4-red
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Li, Bin-Chun, Bingbing Wu, Xueting Hou та Guo-Bin Ding. "Substrate Selectivities of GH78 α-L-Rhamnosidases from Human Gut Bacteria on Dietary Flavonoid Glycosides". Molecules 30, № 5 (2025): 980. https://doi.org/10.3390/molecules30050980.

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α-L-rhamnosidases play a key role in the metabolism and biodegradation of dietary flavonoid glycosides. We have developed a novel microplate spectrophotometric method to rapidly evaluate the conversion rates and substrate selectivities of mesophilic α-L-rhamnosidases towards citrus flavanone diglycosides by combining with a high-active and thermophilic β-D-glucosidase based on UV-visible spectral differences between citrus flavanone diglycosides and the corresponding aglycones under alkaline conditions. Furthermore, catalytic activities and enzyme kinetics of four α-L-rhamnosidases from human
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33

Tine, Yoro, Yin Yang, Franck Renucci, Jean Costa, Alassane Wélé, and Julien Paolini. "LC-MS/MS Analysis of Flavonoid Compounds from Zanthoxylum zanthoxyloides Extracts and Their Antioxidant Activities." Natural Product Communications 12, no. 12 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201213.

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Flavonoids are a large group of phenolic secondary metabolites having a wide range of biochemical and pharmacological effects. In this work, a targeted liquid chromatography (LC) coupled with tandem mass spectrometry (MS2) was used to characterize the flavonoid compositions of methanolic plant extracts from separated parts (fruits, leaves, stems, trunk barks, and root barks) of Zanthoxylum zanthoxyloides. Nine flavonoids were reported in this species, including three flavanones, five flavonols and one flavone. Quantitative analysis of flavonoid profiles from Z. zanthoxyloides extracts is usefu
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34

Xue, Rasmussen, and G. Lane. "Cold stress in white clover - An integrated view of metabolome and transcriptome responses." NZGA: Research and Practice Series 12 (January 1, 2006): 35–40. http://dx.doi.org/10.33584/rps.12.2006.3044.

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We have studied metabolic and gene expression responses of two white clover genotypes differing in foliar basal flavonol and anthocyanin levels subjected to moderate cold in a controlled climate chamber experiment. The main flavonols and anthocyanins accumulating in white clover leaves are conjugated to galactose and xylose. Concentrations of flavonoids and sugars including starch significantly increased during cold treatment and a strong induction of flavonoid pathway genes was observed in both genotypes. Specific sugars like glucose, fructose, and starch were significantly higher in the geno
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Wang, Tao, Fengjiao Zhang, Weibing Zhuang, Xiaochun Shu, and Zhong Wang. "Metabolic Variations of Flavonoids in Leaves of T. media and T. mairei Obtained by UPLC-ESI-MS/MS." Molecules 24, no. 18 (2019): 3323. http://dx.doi.org/10.3390/molecules24183323.

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The needles of Taxus species contain a large number of bioactive compounds, such as flavonoids. In the present study, the total flavonoid content in leaves of Taxus media and Taxus mairei was 19.953 and 14.464 mg/g, respectively. A total of 197 flavonoid metabolites (70 flavones, 42 flavonols, 26 flavone C-glycosides, 20 flavanones, 15 anthocyanins, 13 isoflavones, 6 flavonolignans, and 5 proanthocyanidins) were identified for the first time by a widely targeted Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS/MS) method within the two Taxus
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36

Rafieian-Kopaei, Mahmoud, Reyhaneh Eskandarian, Elham Bijad, Majid Banitalebi, and Mohammad Rahimi-Madiseh. "In vitro evaluation of the amount of flavonoids, flavanols, and total phenolic compounds in 10 medicinal plants used in Iran; focus on diabetes and kidney diseases." Journal of Renal Endocrinology 8 (January 1, 2022): e21068. http://dx.doi.org/10.34172/jre.2022.21068.

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Introduction: Free radicals and reactive oxygen species (ROS) as oxidants are important concerns in medicine due to their adversative effects and risk of carcinogenicity. Antioxidants can neutralize free radicals and ROS thus possesses protective effect on the body. Plants are rich sources of natural antioxidants and phenolic compounds are among the most important antioxidants in the plants; therefore, many studies have investigated their protective effects. Objectives: This study was conducted to evaluate and compare the number of flavonoids, flavonols, and total phenolic compounds in 10 comm
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Jeganathan, Brasathe, P. A. Nimal Punyasiri, J. Dananjaya Kottawa-Arachchi, et al. "Genetic Variation of Flavonols Quercetin, Myricetin, and Kaempferol in the Sri Lankan Tea (Camellia sinensisL.) and Their Health-Promoting Aspects." International Journal of Food Science 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/6057434.

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Flavonol glycosides in tea leaves have been quantified as aglycones, quercetin, myricetin, and kaempferol. Occurrence of the said compounds was reported in fruits and vegetable for a long time in association with the antioxidant potential. However, data on flavonols in tea were scanty and, hence, this study aims to envisage the flavonol content in a representative pool of accessions present in the Sri Lankan tea germplasm. Significant amounts of myricetin, quercetin, and kaempferol have been detected in the beverage type tea accessions of the Sri Lankan tea germplasm. This study also revealed
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Feng, Xinghua, Sining Bai, Lianxia Zhou, et al. "Integrated Analysis of Transcriptome and Metabolome Provides Insights into Flavonoid Biosynthesis of Blueberry Leaves in Response to Drought Stress." International Journal of Molecular Sciences 25, no. 20 (2024): 11135. http://dx.doi.org/10.3390/ijms252011135.

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Blueberries (Vaccinium spp.) are extremely sensitive to drought stress. Flavonoids are crucial secondary metabolites that possess the ability to withstand drought stress. Therefore, improving the drought resistance of blueberries by increasing the flavonoid content is crucial for the development of the blueberry industry. To explore the underlying molecular mechanism of blueberry in adaptation to drought stress, we performed an integrated analysis of the metabolome and transcriptome of blueberry leaves under drought stress. We found that the most enriched drought-responsive genes are mainly in
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39

Tahir, Iqmal, Mohd Noor Ahmad, AKM Shafiqul Islam, and Dachyar Arbain. "VIRTUAL SEARCHING OF DUMMY TEMPLATE FOR SINENSETIN BASED ON 2D MOLECULAR SIMILARITY USING CHEMDB TOOL." Indonesian Journal of Chemistry 12, no. 3 (2012): 217–22. http://dx.doi.org/10.22146/ijc.21333.

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Sinensetin-like molecules have been searched virtually to find a dummy template for Molecular Imprinted Polymer (MIP) synthesis. The aim of this study is to find a novel adsorbent for Solid Phase Extraction (SPE) of sinensetin based on tailored method using dummy template. Virtual searching was done using ChemDB online chemical database containing 5 million commercially available chemicals. Sinensetin as target was converted into SMILES code then it was run with threshold of molecular similarity score of 0.5. There were 90 chemical structures given as the output mainly flavone analogue, three
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Ma, Xintong, Yuying Hou, Abdul Wakeel Umar, et al. "Safflower CtFLS1-Induced Drought Tolerance by Stimulating the Accumulation of Flavonols and Anthocyanins in Arabidopsis thaliana." International Journal of Molecular Sciences 25, no. 10 (2024): 5546. http://dx.doi.org/10.3390/ijms25105546.

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Flavonol synthase gene (FLS) is a member of the 2-oxoglutarate-dependent dioxygenase (2-ODD) superfamily and plays an important role in plant flavonoids biosynthetic pathways. Safflower (Carthamus tinctorius L.), a key source of traditional Chinese medicine, is widely cultivated in China. Although the flavonoid biosynthetic pathway has been studied in several model species, it still remains to be explored in safflower. In this study, we aimed to elucidate the role of CtFLS1 gene in flavonoid biosynthesis and drought stress responses. The bioinformatics analysis on the CtFLS1 gene showed that i
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Graham, Terrence L. "Flavonoid and flavonol glycoside metabolism in Arabidopsis." Plant Physiology and Biochemistry 36, no. 1-2 (1998): 135–44. http://dx.doi.org/10.1016/s0981-9428(98)80098-3.

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42

Xu, Yong, Ruotong Wang, Yuanxiao Ma, et al. "Metabolite and Transcriptome Profiling Analysis Provides New Insights into the Distinctive Effects of Exogenous Melatonin on Flavonoids Biosynthesis in Rosa rugosa." International Journal of Molecular Sciences 25, no. 17 (2024): 9248. http://dx.doi.org/10.3390/ijms25179248.

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Although the petals of Rosa rugosa are rich in flavonoids and their bioactivity has a significant impact on human health, the flavonoid content decreases during flower development. In this study, R. rugosa ‘Feng hua’ was used to investigate the effects of the melatonin foliar spray on enhancing the quality of rose by focusing on major flavonoids. The results showed that the contents of total flavonoids in rose petals at the full bloom stage induced by melatonin obeyed a bell-shaped curve, with a maximum at 0.3 mM, indicating the concentration-dependent up-regulation of flavonoid biosynthesis.
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43

Pu, Ran, Yawen Wu, Tian Bai, et al. "Molecular and Metabolic Regulation of Flavonoid Biosynthesis in Two Varieties of Dendrobium devonianum." Current Issues in Molecular Biology 46, no. 12 (2024): 14270–90. https://doi.org/10.3390/cimb46120855.

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Dendrobium devonianum is an important medicinal plant, rich in flavonoid, with various pharmacological activities such as stomachic and antioxidant properties. In this study, we integrated metabolome and transcriptome analyses to reveal metabolite and gene expression profiles of D. devonianum, both green (GDd) and purple-red (RDd) of semi-annual and annual stems. A total of 244 flavonoid metabolites, mainly flavones and flavonols, were identified and annotated. Cyanidin and delphinidin were the major anthocyanidins, with cyanidin-3-O-(6″-O-p-Coumaroyl) glucoside and delphinidin-3-O-(6″-O-p-cou
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44

Su, Mengyue, Rebecca Njeri Damaris, Zhengrong Hu, Pingfang Yang, and Jiao Deng. "Metabolomic Analysis on the Petal of ‘Chen Xi’ Rose with Light-Induced Color Changes." Plants 10, no. 10 (2021): 2065. http://dx.doi.org/10.3390/plants10102065.

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Flower color is one of the most prominent traits of rose flowers and determines their ornamental value. The color of the “Chen Xi” rose can change from yellow to red during flower blooming. In the present study, the flavonoid metabolites were investigated by the UPLC-ESI-MS/MS from the petals of four successive flower development stages under natural conditions. In total, 176 flavonoid components, including 49 flavones, 59 flavonols, 12 flavanones, 3 isoflavones, 12 anthocyanins, and 41 proanthocyanidins were identified, with some of them being detected for the first time in this study. Additi
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Cattivelli, Alice, Melissa Zannini, Maddalena De Angeli, et al. "Bioaccessibility of Flavones, Flavanones, and Flavonols from Vegetable Foods and Beverages." Biology 13, no. 12 (2024): 1081. https://doi.org/10.3390/biology13121081.

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The bioaccessibility of flavonoids is of paramount importance in determining their bioavailability and biological effects. Bioaccessibility is influenced by several aspects, comprising the food matrix and the structure of flavonoids. In the present study, the bioaccessibility of different classes of flavonoids (flavanones, flavones, and flavonols) was investigated after in vitro gastro-intestinal digestion of beverages and vegetables. O-glycosylated flavanones were stable during in vitro digestion and easily released from the food matrix. Otherwise, C-glycosylated flavanones displayed a lower
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46

Kostikova, Vera A., and Tatiana N. Veklich. "HPLC analysis of phenolic compounds in leaves and inflorescences of Sorbaria pallasii." BIO Web of Conferences 24 (2020): 00040. http://dx.doi.org/10.1051/bioconf/20202400040.

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At least 22 phenolic compounds were identified in aqueous-ethanol extracts from Sorbaria pallasii (G. Don fil.) Pojark. leaves and at least 28 in its inflorescences by High-Performance Liquid Chromatography. Two acids (chlorogenic and p-hydroxybenzoic) and five flavonols (hyperoside, isoquercitrin, quercitrin, kaempferol, and astragalin) were identified among them. Flavonoid aglycones were obtained from the leaves and inflorescences by hydrochloric-acid hydrolysis of the aqueous-ethanol extracts (1:1). Three flavonol aglycones (quercetin, kaempferol, and isorhamnetin) were identified in the ex
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47

Yu, Sang Gong, Douglas A. Gage, Nianbai Fang, and Tom J. Mabry. "Flavonols and Flavonol Glycosides from Eupatorium areolare var. leiocarpum." Journal of Natural Products 49, no. 1 (1986): 181–82. http://dx.doi.org/10.1021/np50043a039.

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48

Iwashina, Tsukasa, Minoru N. Tamura, Yoshinori Murai, and Junichi Kitajima. "New Flavonol Glycosides from the Leaves of Triantha Japonica and Tofieldia Nuda." Natural Product Communications 8, no. 9 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800917.

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Two new flavonol glycosides were isolated from the leaves of Triantha japonica, together with eight known flavonols, kaempferol 3- O-sophoroside, kaempferol 3- O-sambubioside, kaempferol 3- O-glucosyl-(1→2)-[glucosyl-(1→6)-glucoside], quercetin 3- O-sophoroside, quercetin 3- O-sambubioside, isorhamnetin 3- O-glucoside, isorhamnetin 3- O-sophoroside and isorhamnetin 3- O-sambubioside. The new compounds were identified as kaempferol 3- O-β-xylopyranosyl-(1→2)-[β-glucopyranosyl-(1→6)-β-glucopyranoside] (1) and isorhamnetin 3- O-β-xylopyranosyl-(1→2)-[β-glucopyranosyl-(1→6)-β-glucopyranoside] (3)
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49

Jin, Jin, Qihong Zhou, Bin Guo, and Zongchao Jia. "Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase." Biomolecules 15, no. 7 (2025): 934. https://doi.org/10.3390/biom15070934.

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DYRK1A kinase is a critical regulator in cellular signaling pathways and a promising therapeutic target for neurodegenerative diseases, diabetes and cancers. Despite its significance, the development of potent, selective and safe inhibitors remains a significant challenge. Several natural flavonoids have been reported to inhibit DYRK1A by binding in the ATP-binding pocket, exhibiting antidiabetic properties. However, a systematic screening of these structural derivatives remains lacking. In this study, we aimed to expand the pool of flavonoid-based DYRK1A inhibitor candidates for drug developm
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Pentu, Narendra, Ajitha Azhakesan, and Pasupuleti Kishore Kumar. "Insilico molecular docking and ADME/T studies of flavonol compounds against selected proteins involved in inflammation mechanism." Journal of Applied Pharmaceutical Research 13, no. 1 (2025): 95–111. https://doi.org/10.69857/joapr.v13i1.706.

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Background: Using computational tools in drug discovery advanced the research in identifying new drug candidates for the benefit of the pharmaceutical industry and assessing the safety and pharmacokinetic profiles of phytochemicals. Understanding the inflammatory mechanism is not possible, but inflammatory signal transduction by cytokines can be mitigated by using the flavonoid class of drugs like flavonols. Methodology: A molecular docking study of flavonol compounds with proteins linked with inflammation was carried out using the AutodockVina program. SwissADME and pkCSM modules were used to
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