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Journal articles on the topic 'Flinders Resistant Line rotte'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lillethorup, Thea Pinholt, Peter Iversen, Gregers Wegener, Doris Jeanne Marie Doudet та Anne Marlene Landau. "α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats". Acta Neuropsychiatrica 27, № 6 (2015): 345–52. http://dx.doi.org/10.1017/neu.2015.24.

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ObjectivesDisturbances in the noradrenergic system, including alterations in the densities of α2-adrenoceptors, are posited to be involved in the pathophysiology of depression. In this study, we investigate the binding of α2-adrenoceptors in regions relevant to depression in an animal model of depression.MethodsUsing in vitro autoradiography techniques and the selective α2-ligand, [3H]RX 821002, we investigated the density of α2-adrenoceptors in female Flinders-sensitive line (FSL) rats, a validated model of depression, and in two traditional control groups – female Flinders-resistant line (FR

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2

Matthews, Keith, Brian A. Baldo, Athina Markou, Olwen Lown, David H. Overstreet, and George F. Koob. "Rewarding electrical brain stimulation: Similar thresholds for flinders sensitve line hypercholinergic and flinders resistant line hypocholinergic rats." Physiology & Behavior 59, no. 6 (1996): 1155–62. http://dx.doi.org/10.1016/0031-9384(95)02212-0.

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3

Mattsson, Hillevi, Zahra Arani, Alfred Bayati, Claes Ekman, David H. Overstreet, and Maria Astin. "Flinders sensitive line (FSL) rats have increased gastric accommodation capacity compared to flinders resistant line (FRL) and sprague dawley (SD) rats." Gastroenterology 124, no. 4 (2003): A677. http://dx.doi.org/10.1016/s0016-5085(03)83431-5.

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4

Janssen, L. J., V. J. Djuric, J. Wattie, J. Otis, and P. M. O'Byrne. "In Vitro Airway Responsiveness of Flinders Sensitive and Resistant Line Rats." Brain, Behavior, and Immunity 14, no. 1 (2000): 62–67. http://dx.doi.org/10.1006/brbi.1999.0573.

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5

Ferreira-Nuño, A., D. H. Overstreet, A. Morales-Otal, and J. Velázquez-Moctezuma. "Masculine sexual behavior features in the Flinders sensitive and resistant line rats." Behavioural Brain Research 128, no. 2 (2002): 113–19. http://dx.doi.org/10.1016/s0166-4328(01)00313-8.

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6

Friedman, E. "Natural and Cellular Immune Responses in Flinders Sensitive and Resistant Line Rats." Neuropsychopharmacology 15, no. 3 (1996): 314–22. http://dx.doi.org/10.1016/0893-133x(95)00235-6.

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7

Jefsen, Oskar, Kristoffer Højgaard, Sofie Laage Christiansen, et al. "Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat." Acta Neuropsychiatrica 31, no. 04 (2019): 213–19. http://dx.doi.org/10.1017/neu.2019.15.

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AbstractObjective:Psilocybin is a serotonin receptor agonist with a therapeutic potential for treatment-resistant depression and other psychiatric illnesses. We investigated whether the administration of psilocybin had an antidepressant-like effect in a rat model of depression.Methods:Using the Flinders Sensitive Line (FSL) rat model of depression, we assessed the antidepressant-like effect of psilocin and psilocybin, measured as a reduction in immobility time in the forced swim test (FST). We measured locomotor activity in an open field test (OFT) to control for stimulant properties of the dr

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8

Zambello, Erika, Patricia A. Jiménez-Vasquez, Aram El Khoury, Aleksander A. Mathé, and Laura Caberlotto. "Acute stress differentially affects corticotropin-releasing hormone mRNA expression in the central amygdala of the “depressed” flinders sensitive line and the control flinders resistant line rats." Progress in Neuro-Psychopharmacology and Biological Psychiatry 32, no. 3 (2008): 651–61. http://dx.doi.org/10.1016/j.pnpbp.2007.11.008.

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9

Liu, Xi-Cong, Sophie Erhardt, Michel Goiny, Göran Engberg, and Aleksander A. Mathé. "Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression." Acta Neuropsychiatrica 29, no. 1 (2016): 54–58. http://dx.doi.org/10.1017/neu.2016.31.

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ObjectiveThere is a growing interest in the role of kynurenine pathway and tryptophan metabolites in the pathophysiology of depression. In the present study, the metabolism of tryptophan along the kynurenine pathway was analysed in a rat model of depression.MethodsKynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were measured by high-performance liquid chromatography (HPLC) in prefrontal cortex (PFC) and frontal cortex (FC) in a rat model of depression, the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL) rats. In addition, KYNA was also measured in hippo

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10

Kanemaru, Kazuya, and Mirko Diksic. "The Flinders Sensitive Line of rats, a rat model of depression, has elevated brain glucose utilization when compared to normal rats and the Flinders Resistant Line of rats." Neurochemistry International 55, no. 7 (2009): 655–61. http://dx.doi.org/10.1016/j.neuint.2009.06.011.

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11

Bay, Vibeke, Denise F. Happ, Maryam Ardalan, et al. "Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery." Brain Research 1737 (June 2020): 146797. http://dx.doi.org/10.1016/j.brainres.2020.146797.

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12

Kanemaru, Kazuya, Kyoko Nishi, and Mirko Diksic. "AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats." Neurochemistry International 55, no. 7 (2009): 529–35. http://dx.doi.org/10.1016/j.neuint.2009.05.008.

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13

Brand, Linda, Jurgens van Zyl, Estella L. Minnaar, et al. "Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression." Acta Neuropsychiatrica 24, no. 4 (2012): 215–25. http://dx.doi.org/10.1111/j.1601-5215.2011.00622.x.

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Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N-methyl-d-aspartate receptor-mediated release of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP). The aim of this study was to determine whether the Flinders Sensitive Line (FSL) rat, a genetic model of depression, presents with corticolimbic changes in basal acetylcholine (ACh) levels and NO/cGMP signalling.Methods: Basal levels of nitrogen oxides (NOx) and both basal and l-arginine-stimulated nitric oxide synthase (NOS) formation of l-citrulline were anal

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14

Overstreet, David H., and Veljko Djuric. "Links between multiple chemical sensitivity and asthma in a rat model of cholinergic hypersensitivity: a brief review." Toxicology and Industrial Health 15, no. 5 (1999): 517–21. http://dx.doi.org/10.1177/074823379901500505.

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Individuals with multiple chemical sensitivity (MCS) also commonly report symptoms of asthma, but, as far as we have been able to determine, no one has yet suggested that an abnormal cholinergic system may provide the link between asthma and MCS. The present brief review provides evidence for such a link by summarizing recent findings in a genetic animal model of cholinergic hyperresponsiveness. The Flinders Sensitive Line (FSL) rats were developed by selective breeding for increased responses to an anticholinesterase agent similar to commonly used organophosphate pesticides. Relative to their

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15

Bannach-Brown, Alexandra, Sandra Tillmann, Malcolm Robert MacLeod, and Gregers Wegener. "Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression." BMJ Open Science 3, no. 1 (2019): e000017. http://dx.doi.org/10.1136/bmjos-2018-000017.

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IntroductionMajor depressive disorder is the leading source of disability globally and current pharmacological treatments are less than adequate. Animal models such as the Flinders Sensitive Line (FSL) rats are used to mimic aspects of the phenotype in the human disorder and to characterise candidate antidepressant agents. Communication between the gut microbiome and the brain may play an important role in psychiatric disorders such as depression. Interventions targeting the gut microbiota may serve as potential treatments for depression, and this drives increasing research into the effect of

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16

Harpøth, A. J., B. Elfving, O. Wiborg, G. Wegener, and H. K. Müller. "The regulation of orexins and their cognate receptors in two distinct rat models of depression and effects of treatments." European Psychiatry 41, S1 (2017): S367. http://dx.doi.org/10.1016/j.eurpsy.2017.02.372.

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IntroductionDepression has sleep disturbances as a key symptom and recently sleep has been suggested as a new area to optimize treatment in depression. Orexin is produced in the hypothalamus and projected throughout the brain innervating a number of structures important in depression. It controls a number of physiological processes including sleep, arousal, cognitive processes and stress, which are affected during depression.ObjectiveThe study examines the possible implications for abnormalities in the orexinergic system in depression. We aim to determine whether treatment targeting this syste

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17

Ribeiro, Deidiane E., Heidi K. Müller, Betina Elfving, Amanda Eskelund, Samia RL Joca, and Gregers Wegener. "Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation." Journal of Psychopharmacology 33, no. 11 (2019): 1436–46. http://dx.doi.org/10.1177/0269881119872173.

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Background: P2X7 receptors (P2X7R) are ligand-gated ion channels activated by adenosine 5’-triphosphate (ATP), which are involved in processes that are dysfunctional in stress response and depression, such as neurotransmitter release, and neuroimmune response. Genetic and pharmacological inhibition of the P2X7R induce antidepressant-like effects in animals exposed to stress. However, the effect of P2X7R antagonism in an animal model of depression based on selective breeding has not previously been studied, and the mechanism underling the antidepressant-like effect induced by the P2X7R blockade

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18

Brand, Sarel Jacobus, and Brian Herbert Harvey. "Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine." Acta Neuropsychiatrica 29, no. 4 (2016): 193–206. http://dx.doi.org/10.1017/neu.2016.44.

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ObjectiveCo-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to produce an animal with more severe as well as treatment-resistant depressive-like behaviours.MethodsMale Flinders sensitive line (FSL) rats, a genetic animal model of depression, were exposed to a stress re-stress model of PTSD [time-dependent sensitisation (TDS)] and compared with stress-naive controls. Seven days after TDS stress, depressive-like and coping behaviou

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19

Brand, Sarel Jacobus, and Brian Herbert Harvey. "Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies." Acta Neuropsychiatrica 29, no. 4 (2016): 207–21. http://dx.doi.org/10.1017/neu.2016.50.

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ObjectivePost-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model of TRD and an abrogated response to imipramine. We extended the investigation by studying the behavioural and monoaminergic response to multiple antidepressants, viz. venlafaxine and ketamine with/without imipramine.MethodsMale Flinders sensitive line (FSL) rats, a genetic model of depression, were exposed to a time-dependent sensitisation (TDS) model of PTSD and compa

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20

Hildreth, Cara M., James R. Padley, Paul M. Pilowsky, and Ann K. Goodchild. "Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 1 (2008): H474—H480. http://dx.doi.org/10.1152/ajpheart.01009.2007.

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Serotonin (5-HT) is crucial to normal reflex vagal modulation of heart rate (HR). Reduced baroreflex sensitivity [spontaneous baroreflex sensitivity (sBRS)] and HR variability (HRV) reflect impaired neural, particularly vagal, control of HR and are independently associated with depression. In conscious, telemetered Flinders-Sensitive Line (FSL) rats, a well-validated animal model of depression, we tested the hypothesis that cardiovascular regulatory abnormalities are present and associated with deficient serotonergic control of reflex cardiovagal function. In FSL rats and control Flinders-Resi

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21

Chen, Fenghua, Jibrin Danladi, Gregers Wegener, Torsten M. Madsen, and Jens R. Nyengaard. "Sustained Ultrastructural Changes in Rat Hippocampal Formation After Repeated Electroconvulsive Seizures." International Journal of Neuropsychopharmacology 23, no. 7 (2020): 446–58. http://dx.doi.org/10.1093/ijnp/pyaa021.

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Abstract Background Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression used in the clinic. Its mechanism of therapeutic action remains uncertain. Previous studies have focused on documenting neuroplasticity in the early phase following electroconvulsive seizures (ECS), an animal model of ECT. Here, we investigate whether changes in synaptic plasticity and nonneuronal plasticity (vascular and mitochondria) are sustained 3 months after repeated ECS trials. Methods ECS or sham treatment was given daily for 1 day or 10 days to a genetic animal model of d

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22

Melas, Philippe A., Malin Wirf, Helder André, Nitya Jayaram-Lindström, Aleksander A. Mathé, and Pia Steensland. "The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-91215-1.

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AbstractAlcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (−)-OSU6162 (OSU) is a monoamine stabilizer that attenuates alcohol-mediated behaviors in both preclinical and clinical settings. However, OSU’s effect on anxiety-like behavior following long-term drinking remains unknown. To this end, we utilized a genetic rat model that exhibits increased anxiety- and depression-like behaviors (Flinders Sen

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