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Journal articles on the topic 'Floating Tablet A Gastro'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Niranjan, Abadhesh Kumar, and Aditya Kumar. "Development and Evaluation of Gastro Retentive Floating Drug Delivery System of Ondansetron Hydrochloride." Journal of Drug Delivery and Therapeutics 11, no. 6 (2021): 150–58. http://dx.doi.org/10.22270/jddt.v11i6.5084.

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The Aim of the present study was to develop & evaluate Gastro-retentive floating Tablet of Ondansetron hydrochloride. The Objective was to calibrate and validate the UV- spectroscopy analytical method and to prepare and optimize the GR Floating tablets of Ondansetron hydrochloride in terms of dissolution release profile. The FDDS of the drug can minimize the fluctuation of drug plasma levels and result to associated adverse reactions, dosing frequency, and improved patient compliance. Conventionally, Ondansetron hydrochloride is taken up 2-3 times daily in the treatment of nausea and vomit

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2

Vaishnav, Parul, Kuldeep Vinchurkar, and Dinesh K. Mishra. "DESIGN AND DEVELOPMENT OF GASTRO-RETENTIVE FLOATING TABLET CASE USING FDM 3D PRINTING TECHNOLOGY." INDIAN DRUGS 61, no. 08 (2024): 44–53. http://dx.doi.org/10.53879/id.61.08.14554.

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The aim of this research was to examine a novel Fused Deposition Model (FDM) 3D Printing Method for creating a gastro-retentive floating tablet case containing metronidazole compressed tablet. Metronidazole was employed as a model drug and successfully integrated into floating tablet case composed of polyvinyl alcohol filament. The tablet design was made by AutoCAD software and the slicing of tablet design was carried out. To evaluate the formulation parameters for 3D printed tablet case, various orifice sizes were optimized. These 3D printed tablet cases were assessed for weight variation, fr

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3

Kapil, Jalodiya, Jain Sourabh, and Shukla Karunakar. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. https://doi.org/10.5281/zenodo.4264695.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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4

Thapa, Prakash, and Seong Jeong. "Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach." Pharmaceutics 10, no. 3 (2018): 161. http://dx.doi.org/10.3390/pharmaceutics10030161.

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To develop sustained release gastro-retentive effervescent floating tablets (EFT), a quality-based experimental design approach was utilized during the composing of a hydrophilic matrix loaded with a high amount of a highly water-soluble model drug, metformin HCl. Effects of the amount of polyethylene oxide WSR 303 (PEO), sodium bicarbonate, and tablet compression force were used as independent variables. Various times required to release the drug, tablet tensile strength, floating lag time, tablet ejection force, and tablet porosity, were selected as the responses. Polymer screening showed th

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Kam, Li-Ying, Jia-Woei Wong, and Kah-Hay Yuen. "In Vivo Evaluation of Thiamine Hydrochloride with Gastro-Retentive Drug Delivery in Healthy Human Volunteers Using Gamma Scintigraphy." Pharmaceutics 15, no. 2 (2023): 691. http://dx.doi.org/10.3390/pharmaceutics15020691.

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A floating tablet system containing thiamine hydrochloride, a model drug with a narrow absorption window, was evaluated. The tablet was found to have a floating lag time of less than 30 s with a sustained drug release over 12 h during in vitro dissolution studies. The gastro-retentive property of the tablet in relation to the bioavailability of thiamine was determined in healthy human volunteers using gamma scintigraphy under fasted and fed conditions. The gastro-retentive time of the floating tablet could be prolonged up to 10 h under the fed state, compared to about 1.8 h in the fasted state

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Rajni, Jain Poorva Jain Sourabh Jain and Aakanchha Jain*. "ANTIHYPERLIPIDIMIC GASTRO FLOATING TABLET OF PRAVASTATIN PREPARED FROM DIFFERENT GRADES OF HPMC POLYMER." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1139–46. https://doi.org/10.5281/zenodo.164195.

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Oral route is the most convenient route for the drug delivery because of ease of administration, economic therapy & patient compliance. Floating drug delivery system (FDDS) is one of the convenient ways than the convectional oral drug administration which keep drugs buoyant is stomach due to their low density than gastric fluid and can be a potential candidate for controlled release of drug over an extended period of time. FDDS are expected to maximize the absorption resulting in enhanced bioavailability and prolong residence time of drug in stomach. Pravastatin is an oral hyperlipidemic d

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8

Rajni, Jain Poorva Jain Sourabh Jain and Aakanchha Jain. "ANTIHYPERLIPIDIMIC GASTRO FLOATING TABLET OF PRAVASTATIN PREPARED FROM DIFFERENT GRADES OF HPMC POLYMER." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1139–46. https://doi.org/10.5281/zenodo.164196.

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Oral route is the most convenient route for the drug delivery because of ease of administration, economic therapy & patient compliance. Floating drug delivery system (FDDS) is one of the convenient ways than the convectional oral drug administration which keep drugs buoyant is stomach due to their low density than gastric fluid and can be a potential candidate for controlled release of drug over an extended period of time. FDDS are expected to maximize the absorption resulting in enhanced bioavailability and prolong residence time of drug in stomach. Pravastatin is an oral hyperlipidemic d

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9

Rajni, Jain Poorva Jain Sourabh Jain and Aakanchha Jain. "ANTIHYPERLIPIDIMIC GASTRO FLOATING TABLET OF PRAVASTATIN PREPARED FROM DIFFERENT GRADES OF HPMC POLYMER." IAJPS,CSK PUBLICATIONS 03, no. 10 (2016): 1139–46. https://doi.org/10.5281/zenodo.164217.

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Oral route is the most convenient route for the drug delivery because of ease of administration, economic therapy & patient compliance. Floating drug delivery system (FDDS) is one of the convenient ways than the convectional oral drug administration which keep drugs buoyant is stomach due to their low density than gastric fluid and can be a potential candidate for controlled release of drug over an extended period of time. FDDS are expected to maximize the absorption resulting in enhanced bioavailability and prolong residence time of drug in stomach. Pravastatin is an oral hyperlipidemic d

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10

Kapil Jalodiya, Sourabh Jain, and Karunakar Shukla. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. http://dx.doi.org/10.30574/gscbps.2020.13.1.0310.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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11

Ullah, Ghufran, Asif Nawaz, Muhammad Shahid Latif, et al. "Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of Helicobacter Pylori: Formulation and Characterization." Gels 9, no. 1 (2023): 43. http://dx.doi.org/10.3390/gels9010043.

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Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to deliver a combination of a fixed dose of two drugs to eliminate Helicobacter pylori (H. pylori) in the gastrointestinal tract. The bilayer tablets were prepared by means of the direct compression technique. The controlled-release bilayer tablets were prepared using various hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M) alone and in

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12

Ittadwar, Parul A., and Prashant k. Puranik. "Formulation and Evaluation of Gastro-retentive Drug Delivery System of Novel Famotidine Phospholipid Complex." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 03 (2023): 250–59. http://dx.doi.org/10.25004/ijpsdr.2023.150304.

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Famotidine is an H2 receptor antagonist belonging to the BCS Class II, characterized by low solubility and limited oral bioavailability. The current study encompasses the formulation of novel famotidine phospholipid complex (FHC) with the aid of design of experiments (Central Composite Design) using solvent evaporation technique to overcome the disadvantages of Famotidine. To further enhance the physicochemical properties of FHC, it was incorporated into gastro-retentive floating tablets (GRDDS) using direct compression technique with sodium bicarbonate as a gas generating agent and its proper

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13

Mehta, Gagandeep, Rajesh Kumar, Ajeet Pal Singh, and Amar Pal Singh. "Design and Evaluation of Gastro-Retentive Floating Tablets of Ibandronic acid." Journal of Drug Delivery and Therapeutics 14, no. 5 (2024): 122–29. http://dx.doi.org/10.22270/jddt.v14i5.6576.

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The objective of this study is Preparation and evaluation of gastro-retentive floating tablets of Ibandronic acid by direct compression method polymers or combination. In this study, Ibandronic acid, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastro retentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDDs are an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper GIT for local or systemic effect. GRDF tablets of Ibandronic acid (200 mg) were characterized with the effects of Carbopo

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14

Bhuyar, Sajali R., Manjiri M. Auti, Shubhangi A. Bhise, et al. "Innovations and advancements in floating tablet drug delivery systems: a comprehensive review." Pharmacy & Pharmacology International Journal 12, no. 5 (2024): 195–200. https://doi.org/10.15406/ppij.2024.12.00452.

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Floating tablets, also known as gastro retentive drug delivery systems (GRDDS), are innovative formulations designed to prolong the retention of drugs in the gastrointestinal tract, particularly the stomach. This approach is highly beneficial for medications with a narrow absorption window in the upper GI tract, requiring extended action or optimal absorption in a specific pH range. The floating mechanism helps improve bioavailability, therapeutic efficacy, and offers controlled drug release, reducing dosage frequency. The formulation of floating tablets typically involves hydrophilic polymers

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15

Pathan, Vasim, Vishal Gulecha, Amar Zalte, and Anil Jadhav. "Design, Development, Formulation, and Evaluation of Gastro retentive Floating Tablet for Anti-diabetic Agent." Asian Pacific Journal of Health Sciences 8, no. 4 (2021): 1–12. http://dx.doi.org/10.21276/apjhs.2021.8.4.1.

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The main aim of the research was to persist the gastric residence time of vildagliptin by designing its gastro-retentive tablet as well as to study the effect of different polymers on its release rate using 23 randomized full factorial designs. Tablets are manufactured by direct compression method. Hydroxypropyl methylcellulose was used as matrixing agent, M.C.C., and Na2Co3 were used. The manufactured tablets assessed for physicochemical parameters such as weight variety, hardness, friability, floating properties (total floating time and floating lag time), in vitro drug release, and drug con

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16

CHOURASIYA, ANJALI, NARENDRA GEHALOT, and SURESH CHANDRA MAHAJAN. "A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 44–49. http://dx.doi.org/10.24092/crps.2021.110201.

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NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of tw

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17

Palla, Sai Sowjanya, Rajkumar Kotha, Anusha Paladugu, E. Rajesh Kumar Reddy, Suryasri Lavanya Adavi, and K. Ramamohan Reddy. "Bilayer Floating Tablets for Gastroretentive Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 3 (2013): 2097–112. http://dx.doi.org/10.37285/ijpsn.2013.6.3.1.

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 Oral delivery of the drug is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations but has a drawback of non-site specificity and short gastric resident time. In recent years, scientific and technological advancements have been made in the development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Among Several approaches of floating systems, Bilayer floating technology is considered as promising approa

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18

V.T. Iswariya, Sitawar Anusha, Varada Bala Gnana Laxmi, and Akshay. "FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF SITAGLIPTIN." International Journal of Scientific Research in Modern Science and Technology 3, no. 6 (2024): 01–08. http://dx.doi.org/10.59828/ijsrmst.v3i6.214.

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This study aimed to develop a novel gastro-retentive drug delivery system in the form of floating tablets containing the antidiabetic medication sitagliptin. Sitagliptin acts by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which helps break down hormones released by the gut in response to food intake, including glucagon-like peptide-1 (GLP-1).The tablets contains Pectin and HPMC K as binders, with lactose monohydrate serving as a diluent. The effervescent agent, utilizing Citric acid as a gas-generating agent, was the basis for causing the tablet to float. Magnesium stearate and talc

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19

Mayur, Aware, Gondkar Sheetal, and Bachhav Rishikesh. "Bilayer Floating Tablet : A Novel Floating Tablet." International Journal in Pharmaceutical Sciences 1, no. 1 (2022): 86–93. https://doi.org/10.5281/zenodo.5895074.

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Out of various drug delivery system the novel drug delivery system is overcomes and then physiological problems of gastric retention by decreasing fluctuations in blood drug concentration level with consequent reduction in the undesirable toxicity and poor efficiency. Approaches have their been introduced to prolong gastric residence time such as the floating system, modified shape, swelling index, expanding system and high density system. Two layer floating drug delivery system is combined principle of bilayer tablet as well as floating mechanism. Bilayer floating tablet is new in the era for

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20

Rushikesh Mahale, Rushikesh Mahale, Dr Shivraj Jadhav Dr. Shivraj Jadhav, and Dr Sunil Mahajan Dr. Sunil Mahajan. "Gastro- Retentive floating tablets: A promising strategy for improving dapsone therapeutic efficacy." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 254–70. https://doi.org/10.35629/4494-1003254270.

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This review explores the formulation and development of floating tablets for gastro-retentive drug delivery systems (GRDDS), focusing on their ability to prolong gastric retention and enhance the therapeutic efficacy of drugs with narrow absorption windows. The article discusses key components of floating tablet systems, mechanisms of buoyancy, materials, methods, and evaluation parameters. The significance of such systems for improving therapeutic outcomes and patient compliance is highlighted, along with the limitations and challenges faced in formulation.Dapsone is a widely used antimicrobi

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21

Sonu, Gangwar, Semwal Nidhi, Joshi Deepika, and Singh Bhavana. "Formulation and evaluation of biodegradable floating drug delivery for solubility enhancement of diclofenac sodium." World Journal of Biology Pharmacy and Health Sciences 13, no. 1 (2023): 103–10. https://doi.org/10.5281/zenodo.7939913.

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This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for the solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) as swelling polymer K100M or K15M is a gas-forming substance. BY direct-compression manufacturing is used to create floating DICL tablets. The tablet characteristics, swelling index, and in vitro resistance of compressed tablets were assessed. Under non-reducing circumstances, in v

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Waghmare, Suchita Gulabrao, Pramod B. Khedekar, and Jayshree R. Aate. "HPMC Based Gastro Retentive Drug Delivery System of Effervescent Guifenesine Tablet for Dry Cough." ECS Transactions 107, no. 1 (2022): 12229–40. http://dx.doi.org/10.1149/10701.12229ecst.

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Recent advances in Novel Drug Delivery System is aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The controlled release drug delivery systems owning the capacity to be engaged in the stomach remains entitled as Gastro Retentive Drug Delivery Systems. One of the novel approaches for better patient compliance is floating drug delivery. Number of Gastro Retentive dosage forms has been designed to prolong gastric residence time. We are trying to overcome less gastric retention time and trying t

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Rohit Jaimini and Dr. Manish Jaimini. "FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 01–10. https://doi.org/10.61280/tjpls.v12i1.170.

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The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations

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Thatikonda, Nihari, Sree Giri Prasad Beri, Krishna Mohan Chinnala, and Aravinda Nalla. "FORMULATION AND IN-VITRO CHARACTERIZATION OF ABACAVIR SULPHATE EFFERVESCENT FLOATING TABLETS." YMER Digital 21, no. 02 (2022): 145–57. http://dx.doi.org/10.37896/ymer21.02/15.

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fter oral administration of Abacavir, rapid absorption occurs from upper part of gastro intestinal tract with peak concentrations occurring at 0.63 - 1 hr after dosing. Conventional drug therapy with tablets produce relatively rapid and high peak blood levels that requires frequent administration to maintain effective range of plasma drug levels. This conventional therapy leads to reduced effectiveness with poor therapeutic management. To overcome the inadequacy of conventional therapy with tablets, floating sustained release Abacavir tablets were developed. Floating sustained release Abacavir

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Kim, Byungsuk, Youngjoo Byun, and Eun Hee Lee. "DoE-Based Design of a Simple but Efficient Preparation Method for a Non-Effervescent Gastro-Retentive Floating Tablet Containing Metformin HCl." Pharmaceutics 13, no. 8 (2021): 1225. http://dx.doi.org/10.3390/pharmaceutics13081225.

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A sustained-release non-effervescent floating matrix tablet was prepared using a simple and efficient direct compression of spray-dried granules containing metformin hydrochloride and cetyl alcohol with hydroxypropyl methylcellulose K15M (HPMC K15M). The design of experiments was employed to explore the optimal composition of the tablet. The similarity factor was employed to evaluate the equivalence in dissolution profiles between the test tablets and Glucophage XR as a reference. Bootstrap analysis was used to eliminate the formulations for which the dissolution profile was potentially inequi

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Sujit, Ubale, Shinde Tejasvee, and Shaikh Adnan. "Phenhylephrine Hydrocloride Gastro Retentive Floating Matrix Tablets Design and in Vitro Evaluation." International Journal of Trend in Scientific Research and Development 3, no. 6 (2019): 588–92. https://doi.org/10.5281/zenodo.3588744.

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The objective of this research is to obtain sustained release of Phenylephrine hydrochloride. In this research work combination of natural and synthetic gums were used in different ratio to get sustain release different gas generating agents were used to float the tablet. Prepared powder blend is subjected to pre formulation studies. Then prepared tablet were evaluated for different evaluation tests. Finally dissolution data was subjected to various release kinetic models to understand release mechanism of drug. Sujit Ubale | Tejasvee Shinde | Adnan Shaikh "Phenhylephrine Hydrocloride Gas

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Ram, Prasad khoteja* Aarti Kori Shivanand Patil. "Formulation And Evaluation Of Effervescent Floating Sustained Release Tablet Of Fruseamide." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3264–76. https://doi.org/10.5281/zenodo.13333791.

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Furosemide a diuretic is a Biopharmaceutical Classification System class IV drug which shows pH dependent solubility and permeability. Furosemide inhibits water reabsorption in the nephron by blocking the sodium potassium co-transporter in the thick ascending limb of the loop of Henle. It is very poorly soluble in stomach medium and having high permeability through stomach but its solubility increases with pH but is impermeable through intestine due to its permeability limitation. The objectives of this study was to prepare sustained release floating tablets of Furosemide a potent loop diureti

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., Chanchal, Saurav Kumar, and Satinder Kakar. "A REVIEW ON FLOATING TABLET." Indian Journal of Pharmaceutical and Biological Research 6, no. 01 (2018): 22–29. http://dx.doi.org/10.30750/ijpbr.6.1.4.

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Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery more over on Gastro retentive drug delivery system that is Floating Drug Delivery System (FDDS).The objective of this study to review on FDDS focusing on its current advancement and its future. Floating systems are low density systems that have sufficiently buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. Floating dosage forms can be prepared as tablets, capsule by adding suitab

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Choudhary, Chanchal, Yogendra Malviya, and Vikas Jain. "A REVIEW ON FLOATING TABLET." International Journal of Pharmaceutical Sciences and Medicine 8, no. 4 (2023): 18–30. http://dx.doi.org/10.47760/ijpsm.2023.v08i04.002.

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Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery more over on Gastro retentive drug delivery system that is Floating Drug Delivery System (FDDS).The objective of this study to review on FDDS focusing on its current advancement and its future. Floating systems are low density systems that have sufficiently buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. Floating dosage forms can be prepared as tablets, capsule by adding suitab

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Singh, Kuldeep, Subheet K. Jain, Karan Razdan, et al. "Formulation and Evaluation of Ferrous Ascorbate Floating Tablets for the Treatment of Anaemia." Drug Delivery Letters 9, no. 4 (2019): 299–307. http://dx.doi.org/10.2174/2210303109666190708151137.

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Background and Objective: Ferrous ascorbate (FA) is preferentially absorbed from the upper gastrointestinal (GI) track, and has low bioavailability due to less residence time of FA in upper GI track. In addition, FA has low solubility and stability at higher pH. The aim of this study was to prepare gastro-retentive tablets of FA in order to increase its gastric residence time and hence, bioavailability. Methods: Floating tablets of FA were prepared by wet granulation method using different retarding polymers, Povidone K30 as binder and sodium bicarbonate as effervescent agent. The prepared flo

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Sharmin, Florida, Md Abdullah Al Masum, SM Ashraful Islam, and Md Selim Reza. "Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 79–85. http://dx.doi.org/10.3329/dujps.v10i2.11784.

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This investigation describes the preparation and in vitro evaluation of gastro retentive floating tablets of atorvastatin calcium. Two hydrophilic cellulose derivatives, Methocel K4M and Methocel K15M CR were used in floating tablets as gel forming agents to control drug release. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The tablets prepared by direct compression technique were evaluated by various quality parameters including weight variation, hardness and buoyancy studies. In vitro drug release was determined for eight hours using USP XXII paddle-type dis

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Nigusse, Birhanu, Tsige Gebre-Mariam, and Anteneh Belete. "Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride." PLOS ONE 16, no. 6 (2021): e0253391. http://dx.doi.org/10.1371/journal.pone.0253391.

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Ranitidine HCl, a selective, competitive histamine H2-receptor antagonist with a short biological half-life, low bioavailability and narrow absorption window, is an ideal candidate for gastro-retentive drug delivery system (GRDDS). Controlled release with an optimum retentive formulation in the upper stomach would be an ideal formulation for this drug. The aim of the present study was therefore to develop, formulate and optimize floating, bioadhesive, and swellable matrix tablets of ranitidine HCl. The matrix tablets were prepared using a combination of hydroxypropyl methylcellulose (HPMC) and

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Ahmad, Sher, Jamshaid Ali Khan, Tabassum Naheed Kausar, et al. "Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability." Molecules 28, no. 6 (2023): 2606. http://dx.doi.org/10.3390/molecules28062606.

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The convenient and highly compliant route for the delivery of active pharmaceutical ingredients is the tablet. A versatile platform of tablets is available for the delivery of therapeutic agents to the gastrointestinal tract. This study aimed to prepare gastro retentive drug delivery floating tablets of silymarin to improve its oral bioavailability and solubility. Hydroxypropyl methylcellulose (HPMCK4M and HPMCK15), Carbopol 934p and sodium bicarbonate were used as a matrix, floating enhancer and gas generating agent, respectively. The prepared tablets were evaluated for physicochemical parame

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Pamu, Sandhya, Subrahmanyam C. V. S, and Patnaik K. S. K. Rao. "Formulation of Gastro-retentive Floating Tablets of Valsartan by 2 power 2 Factorial Designs: In vitro and In vivo Evaluations." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 2 (2019): 4496–505. http://dx.doi.org/10.37285/ijpsn.2019.12.2.7.

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An oral dosage form containing gastro-retentive floating tablets forms a stomach-specific drug delivery system for the treatment of hypertension. Valsartan belongs to the BCS class II (poo Classification System). It is desirable to improve the extent of bioavailability (23%). The objective of the present study was to apply design of experiment to optimize floating drug delivery of valsartan by employing 22 factorial design. Improvement of the aqueous solubility of valsartan was done by solid dispersions using hot melt extrusion technique. Plasdone S630 copovidone is a variable carrier and drug

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Kumar, Deepak, Mayank Bansal, and Monkia Sharma. "Formulation and Evaluation of Optimized Natural Detoxifying Agents effervescent granuels into Gastro-retentive tablet." Journal of Biomedical and Pharmaceutical Research 14, no. 3 (2025): 42–52. https://doi.org/10.32553/jbpr.v14i3.1321.

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Turmeric extract, garlic extract, and ginger extract have been traditionally used for their medicinal properties, and their combination may offer a synergistic effect in promoting health and well-being. Turmeric extract, rich in curcumin, has potent antioxidant and anti-inflammatory properties, which may help in reducing inflammation and oxidative stress. The research paper focused on Formulation and Evaluation of Optimized Natural Detoxifying Agents effervescent granuels into Gastro-retentive tablet containing a combination of turmeric extract, garlic extract, and ginger extract as natural de

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Bakshi, Vasudha, Swapna S., Deepa Kumari Choudhary, Ch Revanth, B. Sai KumarCh. Praveen, and Ch Praveen. "Design and characterization of metoprolol floating matrix tablet." Pharmaceutical and Biological Evaluations 4, no. 2 (2017): 118. http://dx.doi.org/10.26510/2394-0859.pbe.2017.18.

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Objective: The objective of the present research was to develop a matrix embedded floating tablet of Metoprolol for the sustained activity and prolongation of gastric residence time to improve the bioavailability of the drug. Metoprolol was chosen as a model drug because it is better absorbed in the stomach than the lower gastro intestinal tract.Methods: The experimental work was divided into pre-formulation studies, formulation development, and evaluation. Standardization of drug and excipients confirmed the authentication of the samples. Floating test were conducted for all formulations, In

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D. V. R. N., Bhikshapathi, Chenna Madipalli Shalina, Vishnu Pulavarthy, and Viswaja Medipally. "Design and in vivo Evaluation of Gastro-retentive Floating Capsules of Amlodipine Besylate in Healthy Human Volunteers." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 6 (2017): 3891–99. http://dx.doi.org/10.37285/ijpsn.2017.10.6.3.

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The aim of this study was to explore the application of Gelucire 43/01 for the design of sustained release gastro retentive drug delivery system of Amlodipine besylate. Gelucire 43/01 has been used in floating sustained release formulations to prolong gastric residence time and increase its bioavailability. Gelucire 43/01 in combination with HPMC and Polyox was used as a release retarding polymer. HPMC of various viscosity grades HPMC K4M, HPMC K15M and HPMC K100M in combination of Gelucire were tested to obtain optimal total floating time as well as controlled drug release for prolonged perio

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Patil, Nilesh Sureshrao, and Kishor Salunkhe. "FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ATORVASTATIN USING STATISTICAL DESIGN (JMP SOFTWARE)." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 19–25. http://dx.doi.org/10.22270/jddt.v9i4-a.3284.

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More complications and cost of promoting of imaginative drugs are more prominent consideration to the improvement of controlled release (CR) drug delivery systems. Sustained release or controlled release drug delivery system helps to reduced toxicity of drug and more patient compliant drug delivery system. The aim of this study is to have efficient means of manufacturirng of Gastro retentive floating tablet of Atorvastatin Calcium. Atorvastatin is used in the treatment of hyperlipidaemia. Oral bioavailability of atorvastatin calcium is less than 12% due to instability and in complete absorptio

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Thulluru, Ashok, M. Mohan Varma, C. M. Setty, Pavan Kumar Chintamaneni, and S. Sriharsha Vardhan. "Formulation and Evaluation of Gastro-Retentive Floating Extended Release Metoprolol Tablets using Sodium Alginate and HPMC K-100M Combination." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2947–54. http://dx.doi.org/10.37285/ijpsn.2015.8.3.9.

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The present study was aimed to convert Metoprolol Succinate convert into Gastro Retentive Floating Tablet (GRFT). The gas generating floating tablets of Metoprolol Succinate were prepared to increase the gastric retention and to extend the drug release up to 12 hr. and thereby enhancing its bioavailability. The floating tablets were formulated using HPMCK 100M alone and with the combination of sodium alginate to the polymer of varying concentrations. The tablets were prepared by non-aqueous wet granulation method. The formulated granules were evaluated for pre-compression studies, after the co

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Bhange, Manjusha A., Mahendra C. Gunde, Shubhada B. Ukey, and Pravinkumar B. Suruse. "Formulation and Evaluation of Gastro Retentive Floating Tablet of Cetirizine Hydrochloride using Linseed Mucilageas Polymer." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1544–47. http://dx.doi.org/10.25258/ijddt.13.4.65.

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This study’s objectives were to create and assess gastric-floating controlled release tablets employing flaxseed mucilage as polymer. Linseed mucilage was isolated from Linum usitatissum seeds. Compatibility studies were performed on drug and other excipients. This study employed individual and mixed polymers to manufacture floating CH tablets. The polymers HPMC, MCC, and linseed mucilage were utilized in various ratios. Five distinct formulae were created (F1-F5 by powder a direct compression method. Formulations was tested for various parameters including in-vitro drug release and floating a

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Nikita, Mhase* Ashwini Wakade Dr. Megha Salve. "Formulation And Evaluation of Cimetidine Floating Tablet." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 276–82. https://doi.org/10.5281/zenodo.15578805.

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Among the more promising GRDS is the Floating Drug Delivery System (FDDS).  Beneficial, FDDS improves stomach retention and boosts the effectiveness of medical treatment.  With oral dose, site-specific delivery, sustained release, delayed release, and instant release have all advanced significantly.  Gastric ulcers and gastro-oesophageal reflux disease (GERD) are commonly treated with cemetidine, a histamine H₂-receptor antagonist. The 1970s saw the discovery of the first H₂ blocker.  To increase its bioavailability, a gastroretentive drug delivery method must be developed

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Dr N Swathi, Dr N. Swathi, J. Madhuritha J. Madhuritha, K. Anusha K. Anusha, S. Kavya S. Kavya, Ch Leena Ch. Leena, and V. Poojitha V. Poojitha. "Formulation and in-vitro evaluation of Gastro retentive floating tablets of Cefixime Trihydrate by using Natural Polymers." International Journal of Pharmaceutical Science Invention 14, no. 3 (2025): 35–46. https://doi.org/10.35629/6718-14033546.

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The Floating drug delivery system is a novel approach in the Gastro retentive drug delivery systems (GRDDS). Floating system is needed for those drugs having a stomach or upper small intestine absorption window. This process does not affect on the rate of gastric emptying over an extended time as it a less dense method and therefore stay buoyant in the stomach and slowly release the drug. System floats on the gastric contents thereby releasing the drug slowly at a desired rate from the system which results in an increased gastric residence time (GRT) and a better control of the fluctuations in

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Pathak, Sudhakar, Harish Pandey, and Sunil Kumar Shah. "Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 298–309. http://dx.doi.org/10.22270/jddt.v9i4-s.3322.

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Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and

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Abdulkhaleq, Nuha Mohammed, and Mowafaq M. Ghareeb. "Combination of FDM 3D Printing and Compressed Tablet for Preparation of Baclofen as Gastro-Floating Drug Delivery System (Conference Paper )#." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, Suppl. (2023): 18–24. http://dx.doi.org/10.31351/vol31isssuppl.pp18-24.

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This study aimed to develop an oral drug delivery system for gastro-retentive sustained drug release of baclofen by using a 3D printed capsular device since baclofen has a short half-life of 2.5 to 4 hours and has a narrow absorption window. Firstly sustained-release tablets of baclofen were formulated through the hot-melt extrusion of various thermoplastic polymers and direct compression of the extrudate, then a capsular device was designed and 3D printed to contain two air pockets to enable floating of the device and has four windows for drug release. 3D printing of the capsular device

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Alatraqchi, Faten Ibraheem, and Fatima J. AL Gawhri. "Preparation and In-Vitro Evaluation as an Oral Microsponge Tablet of Baclofen." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 1 (2019): 75–90. http://dx.doi.org/10.31351/vol28iss1pp75-90.

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The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release

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Chareonying, Thapakorn, Prasert Akkaramongkolporn, and Praneet Opanasopit. "Development of Floating 3D-Printed Devices for Carvedilol Tablet." Key Engineering Materials 914 (March 21, 2022): 45–51. http://dx.doi.org/10.4028/p-fgf5qq.

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A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach environment). Hence, floating 3D-printed devices (FD) were developed from polylactic acid (PLA) filaments using fused deposition modeling (FDM) and designed to be a tablet shape with an anti-flip-up property as GRDDS of carvedilol tablets. There were two parts of FD, including the cap and the base. The base was designed with different hole diameters (2.5, 3.5, and 4.5 mm) for a

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Satyam, Pendor* Dr. A. V. Chandewar Dr. M. A. Channawar Gaurav Magar. "Design, Development and Optimization of Floating Gastro-Retentive Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4454–72. https://doi.org/10.5281/zenodo.15532437.

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The present study focused on the formulation and evaluation of lamivudine-loaded floating tablets aimed at controlled drug delivery. Physical and analytical characterization confirmed the identity and purity of lamivudine, with the standard calibration curve exhibiting excellent linearity (R² = 0.9992). Solubility and IR studies revealed that lamivudine is soluble in water and chemically compatible with the selected polymers. Among various microsphere formulations (F1–F10), batch F10 showed the highest percentage yield (23%), indicating optimized formulation conditions. Pre- and pos

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Radhika, Parasuram Rajam, Nishala N, Kiruthika M, and Sree Iswarya S. "DESIGN AND EVALUATION OF INTRAGASTRIC BUOYANT TABLETS OF VENLAFAXINE HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 166. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.16948.

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Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate theintragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulationswere formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration ofdrug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent.Methods: The tablets wer

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Panda, Subhranshu, C. H. Surya Kumari, and G. Puniya. "FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 6 (2018): 82. http://dx.doi.org/10.22159/ijpps.2018v10i6.25367.

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Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disint

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SHARMA, RAJESH, and ASHWANI MISHRA. "DEVELOPMENT AND CHARACTERIZATION OF GASTRO RETENTIVE TABLETS OF CLARITHROMYCIN FOR ANTIULCER EFFECT." Current Research in Pharmaceutical Sciences 12, no. 1 (2022): 40–45. http://dx.doi.org/10.24092/crps.2022.120106.

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Gastroretentive floating drug delivery system (GFDDS) is used to prolong the gastric residence time after oral administration, at a particular site and controlled or modified the release of drug from the formulation.The purpose of the present study is to develop a gastro retentive floating drug delivery system to achieving controlled release so that is improves bioavailability of the formulation, Structure activity relationship based on Biopharmaceutical Properties of Clarithromycin indicates good biopharmaceutical Properties. Floating dosage form of Clarithromycin was designed for the treatme

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