Academic literature on the topic 'Fluid bed drying'
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Journal articles on the topic "Fluid bed drying"
Akhtaruzzaman, M., MR Ali, MM Rahman, and MS Ahamed. "Drying tea in a kilburn vibro fluid bed dryer." Journal of the Bangladesh Agricultural University 11, no. 1 (March 5, 2014): 153–58. http://dx.doi.org/10.3329/jbau.v11i1.18227.
Full textTemple, S. J., and A. J. B. van Boxtel. "Control of Fluid Bed Drying of Tea." IFAC Proceedings Volumes 31, no. 9 (June 1998): 37–41. http://dx.doi.org/10.1016/s1474-6670(17)44025-0.
Full textGroenewold, H., and E. Tsotsas. "A NEW MODEL FOR FLUID BED DRYING." Drying Technology 15, no. 6-8 (July 1997): 1687–98. http://dx.doi.org/10.1080/07373939708917318.
Full textMoreno, Rogelio, and José Oyarzo. "SAWDUST FLUID-BED DRYING WITH HEATING TUBES." Drying Technology 16, no. 1-2 (January 1998): 351–67. http://dx.doi.org/10.1080/07373939808917410.
Full textBenelli, Lucimara, Diego F. Cortés-Rojas, Claudia Regina F. Souza, and Wanderley Pereira Oliveira. "Fluid bed drying and agglomeration of phytopharmaceutical compositions." Powder Technology 273 (March 2015): 145–53. http://dx.doi.org/10.1016/j.powtec.2014.12.022.
Full textTsotsas, Evangelos. "FROM SINGLE PARTICLE TO FLUID BED DRYING KINETICS." Drying Technology 12, no. 6 (January 1994): 1401–26. http://dx.doi.org/10.1080/07373939408961013.
Full textPovrenovic, Dragan, and Suzana Dimitrijevic-Brankovic. "Drying of biological materials in a spout-fluid bed with a draft tube." Chemical Industry 56, no. 4 (2002): 141–46. http://dx.doi.org/10.2298/hemind0204141p.
Full textSalam, Aziz, Femy M. Sahami, Citra Panigoro, Yayu Indriati Arifin, and Masayuki Sakakibara. "Threats to Food Safety and Sustainability of Nike (Awaous melanocephalus) in Gorontalo Province." KnE Life Sciences 2, no. 6 (November 26, 2017): 43. http://dx.doi.org/10.18502/kls.v2i6.1018.
Full textSuherman, Suherman, Mohammad Djaeni, Dyah Hesti Wardhani, and Andri Cahyo Kumoro. "Paddy Drying in Batch Fluidized Bed and Scale-up Simulation in Continuous Operation Mode." KnE Life Sciences 2, no. 6 (November 26, 2017): 430. http://dx.doi.org/10.18502/kls.v2i6.1064.
Full textTemple, S. J., S. T. Tambala, and A. J. B. van Boxtel. "Monitoring and control of fluid-bed drying of tea." Control Engineering Practice 8, no. 2 (February 2000): 165–73. http://dx.doi.org/10.1016/s0967-0661(99)00145-8.
Full textDissertations / Theses on the topic "Fluid bed drying"
Haeri, Nejad Masoud. "Drying of Porous Particles containing Liquid Mixtures in a Continuous Vibrated Fluid Bed Dryer." Thesis, KTH, Skolan för kemivetenskap (CHE), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-156215.
Full textInverkan av driftparameter på torkning av sfäriska porösa partiklar som innehåller lösningsmedelblandningar som avdunstar i kväve i en kontinuerligt viberande fluidbädd-tork studerades. En simuleringsmodell baserad på den analytiska lösningen till värme- och materieöverföringsekvationerna användes och ändringar föreslogs. Fyra olika tärnar vätskeblandningar valdes: aceton-kloroform-metanol(ACM), etanol-2- propanolvatten,(EIpW), vatten-etanol-etylacetat (WEEa) och etanol-metyletylketon- toluen(EMekT). För den fasta fasen användes fysikaliska egenskaper liknande Pyrex. Sammansättnings- och temperatur-profiler visade att det inte finns något motstånd mot värmeöverföring i den fasta fasen och att värmeöverföringen sker mycket snabbare än materieöverförningen. Selektivitetsdiagram ritades. Resultaten indikerar att selektivititen är en viktig parmeter för att förutsäga beteendet vid torkning. Retentionsförhållandet användes som ett prestandamått. Dess variation med avseende på förändringar av driftsparmetrar, bland annat gasen hastighet och temperatur samt den fasta fasens temperatur och partikelstorlek, studerades. En modifiering av modellen undersöktes genom att införa en vätskehalts-beroende faktor för diffusionsmotståndet. Detta minskade värdena på retentionsförhållandena. Vibrationens inverkan på värme- och materieöverföring infördes genom att använda Sbrodov samband, och den resulterande effekten på retentionsförhållandet observerades.
Eriksson, Linnea. "Multi-factorial Optimization of the Clean-In-Place program for a Fluid Bed Dryer after Drying of Ferrous Granules." Thesis, Uppsala universitet, Institutionen för farmaci, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-263552.
Full textAlonso, Ellen Cristine Pineze. "Desenvolvimento de complexos de inclusão sólidos contendo carvedilol e ciclodextrina pelas técnicas de leito fluidizado e spray drying." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/7019.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Introduction: Cyclodextrins have been used in several industries segments, mainly in the pharmaceutical industry. This material has been employed in the complexation of poorly soluble drugs with the aim to increase bioavailability and effect. Carvedilol (CARV) is a poor soluble drug used in the treatment of hypertension and congestive heart failure. Its oral bioavailability is reduced to β5%, due to their low aqueous solubility and first pass effect. Because of this, it is an excellent choice to form inclusion complexes with cyclodextrins. However, the use of cyclodextrins have some limitations, once it is necessary to use a large amount in the formulation and it can cause dilution of the drug and it can result in a solid oral form with inappropriate dimensions. Therefore, different strategies have been used to enhance complexation efficiency and reduce the amount of cyclodextrin, like the combination of the effect of drug ionization and inclusion complexes. In addition, the choice of the technique used to produce inclusion complexes is very important, because it is necessary to develop economic and effective techniques, which have been easily scalable to produce inclusion complexes in the industry. Spray drying technique have been extensively studied in cyclodextrin complexation, but this method is very expensive and presents lower efficiency. On the other hand, fluid-bed granulation has been widely used in the production of solid dosage forms but the use of this technique to produce cyclodextrin inclusion complexes is not described in the literature. Objective: The purpose of this study is to produce and characterize inclusion complexes containing carvedilol and cyclodextrin, using spray drying and fluidized bed techniques, with the aim to enhance drug dissolution rate. Material and methods: Phase solubility studies were performed using various cyclodextrins, in pH 1,β and 6,8, at room temperature, during 48 hours. Binary complexes were produced by spray drying and fluidized bed techniques. FTIR spectroscopy, DSC analysis, morphology, particle size, flowability and dissolution studies were performed to characterize the inclusion complexes. Results and discussion: Hidroxypropyl--cyclodextrin Cavitron W7 HP7 had the better solubility results. Thus, binary complexes CARV: HPCD prepared by spray drying and fluidized bed techniques in pH β,β showed better results and dissolution rate was 7 and 6 folds, respectively. However, solid dispersion prepared by fluid-bed presented better flowability indicating that this technique is the most appropriate for a large-scale production of solid dosage forms. Additionally, complexes containing HPȖCD showed good dissolution rate and could be considered as one more option for CARV complexation with great performance of inclusion complex formation in solid state.
Introdução: As ciclodextrinas têm sido amplamente utilizadas principalmente na indústria farmacêutica. Esses adjuvantes são usados na complexação de fármacos que apresentam baixa solubilidade aquosa, resultando em produtos com maior biodisponibilidade e portanto, efeito terapêutico superior. O carvedilol (CARV) é um fármaco pouco solúvel utilizado no tratamento da hipertensão e insuficiência cardíaca congestiva. Esse fármaco tem biodisponibilidade oral de apenas β5%, devido à sua baixa solubilidade aquosa e ao efeito de primeira passagem metabólica, sendo um excelente candidato a complexação com as ciclodextrinas. No entanto, o uso de ciclodextrinas em formas farmacêuticas sólidas é limitado pela necessidade de adicionar elevadas quantidades desses adjuvantes na formulação, o que ocasiona à diluição do fármaco e o aumento indesejado no tamanho da forma farmacêutica. Assim, diversas estratégias têm sido empregadas para aumentar a eficiência de complexação e reduzir a quantidade de ciclodextrina utilizada, como a ionização de fármacos associada a formação de complexos de inclusão. Outra preocupação importante é a seleção do método de complexação, pois é necessário desenvolver técnicas eficientes, econômicas e de fácil escalonamento visando a futura produção industrial dos complexos. O método de spray drying tem sido muito investigado para a obtenção de complexos com ciclodextrinas, mas apresenta baixa eficiência energética e custo elevado. Por outro lado, o método de leito fluidizado tem sido extensivamente utilizado na indústria farmacêutica, mas seu emprego como método de complexação durante a granulação de pós ainda não foi descrito na literatura. Objetivo: A proposta deste trabalho foi obter e caracterizar complexos de inclusão contendo carvedilol e ciclodextrinas, pelas técnicas de spray drying e leito fluidizado, visando melhorar a dissolução do fármaco a partir de formas farmacêuticas sólidas. Materiais e Métodos: Estudo de solubilidade de fases com diferentes tipos de ciclodextrinas foram realizados em soluções de pH 1,β e 6,8, sob temperatura ambiente, durante 48 horas. Complexos sólidos binários foram preparados pelas técnicas de spray drying e leito fluidizado. Os complexos de inclusão foram caracterizados por espectroscopia na região do infravermelho (FTIR), calorimetria exploratória diferencial (DSC), morfologia, tamanho de partícula, fluxo e avaliados quanto a dissolução do fármaco. Resultados e discussão: A ciclodextrina que apresentou melhor capacidade de solubilização do carvedilol foi a hidroxipropil-ȕ- ciclodextrina (HPȕCD) com maior grau de substituição (Cavitron W7 HP7). Complexos binários CARV: HPȕCD, preparados por spray drying e leito fluidizado, em pH β,β, apresentaram os melhores resultados, sendo o aumento na taxa de dissolução de 7 e 6 vezes, respectivamente. No entanto, a dispersão sólida preparada em leito fluidizado apresentou propriedades de fluxo superiores demonstrando que esta técnica é a mais adequada para a produção de formas sólidas em grande escala. Adicionalmente, os complexos contendo HPȖCD também apresentaram resultados de dissolução satisfatórios, sendo esta ciclodextrina modificada uma alternativa para a formação de complexos de inclusão contendo CARV.
Souza, Luciane Franquelin Gomes de 1977. "Fluidodinamica e secagem de cloreto de potassio e acetato de sodio em leito pulso fluidizado." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267207.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Acetato de sódio e um sal orgânico produzido pela reação do acido acético com hidróxido de sódio. Depois da cristalização e separação os cristais úmidos são secos. Já o cloreto de potássio e um sal inorgânico extraído de rochas e águas salinas muito utilizado na industria química como fertilizante. Esses sais são higroscópicos, coesivos quando úmidos, e geralmente são secos em secadores de leitos fluidizados. No presente trabalho foi utilizado um secador de leito pulso-fluidizado (PFB) que e uma modificação do secador de leito fluidizado convencional. Neste equipamento uma taxa constante de ar e suprido para o secador. Um distribuidor de gás instalado sob a câmara de secagem promove a pulsação pela corrente de gás alternada. A principal vantagem desta técnica e o uso de uma vazão de ar menor quando comparada com outras. O PFB utilizado neste trabalho possui uma área de secção transversal de 0,18 metros quadrados e constituído de quatro seções. Inicialmente foi realizado o estudo fluidodinâmico dos sais secos e úmidos. Posteriormente as curvas de secagem do acetato de sódio e cloreto de potássio foram determinadas para diferentes condições de secagem (temperatura do ar e freqüência de pulsação). A secagem e fluidodinâmica em leito fluidizado convencional foram feitas para que a comparação com o leito pulsado fosse possível. Resultados mostraram que as taxas de secagem foram maiores na fluidizarão pulsante devido ao melhor comportamento fluidodinâmico: o fluxo intermitente ajuda a romper partículas aglomeradas e conseqüentemente prover melhor contato entre gás - partícula.
Abstract: Sodium acetate is a salt produced by the reaction of acetic acid with sodium hydroxide. After crystallization and separation, the wet crystals are dried. Potassium chloride is an inorganic salt extracted from rocks and saline water. It is mainly used in the chemical industry as a fertilizer. These salts are hygroscopic particulate materials, which are dried in fluidized beds or rotary dryers. In this work a pulsed-fluid bed (PFB) dryer was used, which is a variation of the conventional fluidized bed dryer. In this equipment, a constant airflow rate is supplied to the dryer. A gas distributor installed upstream of the drying chamber provides the pulsed-flow by alternating the gas stream. The main advantage of this technique is the lower airflow rate supplied when compared with competitive techniques. The PFB used in this work has a cross section area of 0.18 m2 and it has four sections. Initially, the fluid-dynamic study of dry and wet salts was performed. Subsequently the drying curves of sodium acetate and potassium chloride were determined for different drying conditions (inlet air temperature and pulsation frequency). Drying and Fluid-dynamic was performed in conventional fluidized bed drying, so that results could be compared. Results showed that the drying rates were higher under pulsed fluidization due to the better fluid-dynamic behavior: the intermittent flow can help to break particle agglomerates and therefore provide better contact between particles and the gas.
Mestrado
Engenharia de Processos
Mestre em Engenharia Química
Godoi, Fernanda Condi de. "Fluidodinamica e secagem do polihidroxibutirato (PHB) em leito fluidizado pulsado rotativo." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267050.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Polihidroxibutirato (PHB) é um poliéster completamente biodegradável e biocompatível. O interesse no desenvolvimento, produção e comercialização do PHB vem crescendo por ser um produto biodegradável e de produção integrada à cadeia de açúcar e álcool. A secagem é uma importante etapa do processo de produção do PHB, pois para o adequado pósprocessamento desse material deve-se garantir um teor de umidade limite de 0,5%. Neste contexto, este trabalho teve como objetivo estudar uma tecnologia de secagem, em um produto inovador e de importância na preservação ambiental. Foi realizado um estudo da fluidodinâmica e dos mecanismos de secagem do PHB em um leito fluidizado pulsado rotativo (LFPR). A escolha do equipamento baseou-se no fato de que o PHB úmido é coesivo e não apresenta fluidização convencional de qualidade. O secador de LFPR utiliza a pulsação do ar para desfazer os aglomerados de PHB melhorando a circulação das partículas dentro do leito. O presente estudo também incluiu a caracterização física do material antes e após a secagem. Para os ensaios de caracterização em que os equipamentos não trabalham em presença de umidade, a liofilização do PHB foi a alternativa encontrada para se caracterizar o material antes da secagem. O PHB apresentou um excelente comportamento fluidodinâmico em LFPR. A frequência de pulsação de 10 Hz foi a que apresentou comportamento mais favorável, com queda de pressão moderada e patamares de estabilidade. Por meio dos ensaios fluidodinâmicos foi possível determinar a velocidade de mínima fluidização vigorosa pulsada (VMV), parâmetro que ajudou a estabelecer a velocidade empregada para os experimentos de secagem. Durante a secagem do PHB foi avaliada a influência que a temperatura, velocidade e frequência de pulsação do ar exercem na cinética de secagem. Verificou-se excelente contato entre as partículas de PHB e o ar aquecido, com elutriação somente nos primeiros 10 minutos de secagem. As curvas de secagem do PHB indicaram períodos de taxa de secagem constante e decrescente. A temperatura e a velocidade do ar influenciaram positivamente o processo. Além disso, foi detectada a existência de um outro solvente além da água nas amostras de PHB, por meio da comparação entre as curvas de secagem obtidas com medidas de umidade feitas em estufa e em Karl Fischer. A análise termogravimétrica (TGA) também ajudou a detectar a presença de outro solvente além da água nas amostras de PHB. Os ensaios de caracterização física mostraram que as condições operacionais de secagem testadas não provocaram a degradação das partículas de PHB. Sob as condições consideradas ótimas de secagem, temperatura de 90 ºC, frequência de 7 Hz e velocidade do ar 0,40 m/s, foi atingida umidade igual a 0,56%, demonstrando a viabilidade do secador LFPR.
Abstract: Poly-hydroxybutyrate (PHB) is polyester, completely biodegradable and biocompatible. The interest on its development, production and commercialization has arisen due to its biodegradability and production integrated to the sugar and alcohol chain. Drying is an important step of the PHB production because an adequate post-processing is achieved only at moisture contents less than 0.5%. The goal of this work was to study a drying technology for this innovative product of relevant importance for the environmental preservation. The fluid-dynamic and drying mechanisms analyses were made in a rotating-pulsed fluidized bed (RPFB). The equipment was chosen based on the fact that the wet PHB is cohesive and doesn't work properly in a conventional fluid bed. The RPFB dryer uses the air pulsation to undo the PHB agglomerate improving the circulation of the particles inside the bed. This study also included the physical characterization of the material before and after the drying. For the characterization tests that wouldn't work with moisture presence, the liophilization was the best alternative to characterize the material before the drying process. The PHBshowed an excellent dynamic behavior in RPFB. The pulsation frequency of 10 Hz presented the most favorable fluid dynamic conditions, resulting in moderate pressure drop and regime stability. Based on the fluid-dynamic study it was possible to determine the minimum vigorous fluidizing air flow (MVF), an important parameter to set the air velocity range for the drying experiments. An excellent contact between the PHB particles and the hot air was obtained during the drying runs, with particles elutriation only during the first 10 minutes. The influence of the temperature, velocity and frequency of air pulsation was evaluated on the drying kinetics. The PHB drying kinetics presented constant and decreasing-rate drying periods. The drying process was positively influenced by the air temperature and velocity. Furthermore, the presence of another solvent additionally to the water was detected in the PHB samples through the comparison between the drying curves obtained with moisture measurements made in an oven and in Karl Fischer equipment. The thermo gravimetric analysis also helped to detect the presence of another solvent in the PHB samples. The physical characterization tests showed that the drying operating conditions didn't cause degradation on PHB particles. The RPFB dryer showed to be a viable technique to dry PHB, as moisture content of 0.56% was reached at optimal operating conditions of air temperature of 90oC, air velocity of 0,40 m/s and frequency of pulsation of 7 Hz.
Mestrado
Engenharia de Processos
Mestre em Engenharia Química
HAUSMAN-MANNING, DEBRA SUE. "APPLICATION OF PROCESS ANALYTICAL TECHNOLOGY TO PHARMACEUTICAL PROCESSES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108838053.
Full textDebaste, Frédéric. "Modélisation de l'évaporation en milieu poreux: développement de modèles fondamentaux et appliqués." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210496.
Full texttransport et de thermodynamique apparaissant lors de l'évaporation
en milieu poreux permet l'investigation d'applications pratiques
variées. Dans ce travail, nous développons des modèles fondamentaux
d'évaporation en milieu poreux que nous appliquons ensuite au
séchage en lit fluidisé de deux matériaux granulaires poreux :le
PVC et la levure.
Les modèles mis au point sont réalisés suivant une approche
multiéchelle. Nous nous intéressons tout d'abord aux phénomènes se
déroulant à l'échelle d'un pore. Les modèles développés à cette
échelle sont ensuite exploités dans le cadre d'une étude à l'échelle
d'un grain poreux. Le couplage des modèles de grain avec un modèle à
l'échelle du réacteur permet alors l'étude des applications
industrielles.
A l'échelle du pore, nous étudions les phénomènes de transport dans
un capillaire initialement rempli de liquide qui s'évapore vers
l'atmosphère ambiante. L'objectif est de prédire le taux
d'évaporation dans cette configuration. Nous nous intéressons
successivement à la modélisation du transport de matière par
convection-diffusion en phase gazeuse et la modélisation de l'impact
de films liquides adsorbés à la paroi du capillaire sur le transport
de matière. Ces deux modèles sont confrontés à des expériences
d'évaporation en capillaires cylindriques visualisées à l'aide de
deux dispositifs optiques. Le premier offre un suivi d'ensemble au
cours du temps du capillaire, alors que le second, un interféromètre
de Mach-Zehnder, permet une visualisation locale de la région
entourant le ménisque.
Le modèle portant sur le transport de matière par
convection-diffusion mène à la définition d'un critère non
dimensionnel permettant d'évaluer si la convection dans la phase
gazeuse dans le capillaire doit être prise en compte pour évaluer le
taux d'évaporation. Le modèle de film permet de prédire l'impact de
celui-ci sur l'évaporation en présence d'un gaz inerte lorsque les
mouvements convectifs en phase gazeuse sont négligeables. La
confrontation de ce modèle avec les profils d'épaisseur des films
obtenus à l'aide de interféromètre de Mach-Zehnder ne permet pas de
valider le modèle, et ce, suite à une trop grande incertitude sur
l'évaluation des interactions entre la paroi et le liquide.
A l'échelle d'un grain, nous développons un modèle discret par
réseau de pores et deux modèles continus pour tenter de prédire le
taux d'évaporation et la distribution des phases dans le milieu
poreux. Le modèle par réseau de pores prend en compte les transports
de matière par diffusion en phase gazeuse, par convection dans les
pores remplis de liquide et par convection dans les films liquides.
Les effets visqueux en phase liquide sont également modelisés. Pour
la prise en compte de ces derniers, nous montrons l'importance de
l'usage d'un algorithme approprié. Nous évaluons ensuite au travers
de trois nombres sans dimensions l'impact du transport par film et
des effets visqueux sur l'évaporation et la distribution des phases.
Cette analyse dimensionnelle est ensuite appliquée à l'étude de
réseaux de pores pour lesquels la section des liaisons les
constituant est idéalisée par des polygones réguliers. Pour les
modèles continus après une vérification simplifiée de
l'applicabilité de cette démarche, nous développons deux modèles
simples. Dans les deux modèles, l'étape de séchage à vitesse
constante est supposée limitée par le transport de matière externe
au grain. Le premier modèle, dit à front pénétrant, suppose que
l'étape de séchage à vitesse décroissante correspond à l'existence
d'un front d'évaporation qui s'enfonce dans la matrice poreuse. Le
second modèle, dit à surface d'échange variable, attribue cette même
étape du séchage à une diminution progressive de la surface
d'évaporation en surface du grain.
A l'échelle du réacteur, nous présentons deux modèles visant à
simuler deux types d'essais différents :le séchage en lit fluidisé
et la thermogravimétrie analytique. Ces deux modèles sont couplés
aux différents modèles à l'échelle de grain pour étudier le séchage
de PVC et de levure tant en lit fluidisé que lors des essais de
thermogravimétrie analytique.
Dans le cas du PVC, le modèle par réseau de pores ne peut pas être
appliqué de par la nécessité d'une trop grande puissance de calcul.
Au niveau des modèles continus, nous montrons que l'application du
modèle à surface d'échange variable permet de reproduire les courbes
de séchage expérimentales des essais en lit fluidisé.
Dans le cas de la levure, nous appliquons le modèle par réseau de
pores et le modèle à front pénétrant. L'utilisation du modèle par
réseau de pores nécessite une connaissance plus détaillée de la
structure poreuse des grains. Le traitement d'une analyse par
microtomographie nous permet d'obtenir un réseau de pores
expérimental. Celui-ci est utilisé pour montrer que la méthode de
caractérisation de la porosité par intrusion de mercure ne semble
pas adaptée à un matériau deformable comme la levure. Le même réseau
est utilisé pour simuler le séchage de grains de levure à l'aide du
modèle par réseau de pores. Les simulations sont réalisées sur des
réseaux équivalents à des coupes dans le solide. Le modèle par
réseau de pores et le modèle à front pénétrant permettent tous deux
de modéliser correctement le séchage de levure en lit fluidisé
moyennant l'ajustement de leurs paramètres ajustables,
respectivement la conductibilité des films liquide et la tortuosité.
Pour l'essai de thermogravimétrie, ils ne parviennent à approcher
que la première étape de celui-ci. Les avantages, défauts et
complémentarités de ces deux modèles sont discutés.
Nous évaluons ensuite l'impact du rétrécissement de la levure et des
types d'eau sur le séchage de ce matériau. Le rétrécissement est,
pour ce faire, mesuré à l'aide d'un stéréomicroscope. Ces premières
mesures, exploratoires, mènent à la définition d'un modèle empirique
de retrait du solide au cours de son séchage. En le prenant en
compte dans les modèles déjà appliqués à la levure, nous montrons
que le retrait a un impact significatif sur l'étape de séchage à
vitesse décroissante. Cet impact
peut cependant être masqué intégralement par la réévaluation
des paramètres ajustables des différents modèles. Finalement,
l'étude des types d'eau au travers d'un modèle simple appliqué à
l'essai de thermogravimétrie analytique montre que les types d'eau
ne doivent pas être pris en compte pour modéliser le séchage de
levure.
A l'issue de ce travail, nous disposons donc de modèles fondamentaux
d'évaporation en milieu poreux. Ceux-ci peuvent être appliqués à des
cas d'intérêt industriel, comme nous le réalisons pour le PVC et la
levure. Ils peuvent servir à améliorer la
compréhension de ces procédés. Ils représentent donc des
outils de choix pour la conception, le dimensionnement et
l'optimisation du séchage.
Doctorat en Sciences de l'ingénieur
info:eu-repo/semantics/nonPublished
Souza, Jonas Laurentino de. "Avaliação da secagem de metformina 850mg em leito fluidizado industrial." Universidade Estadual do Oeste do Parana, 2012. http://tede.unioeste.br:8080/tede/handle/tede/1840.
Full textThe oral administration of drugs for systemic effects is the most common way used in medical treatment. Among these, drugs as tablets are the most used. The granulation is a process that seeks to improve the transportation of powder in the compacting machine by the agglomeration of particles. The fluidized bed drying added to "spray dryer" technique is commonly used to form granules that reaches the required characteristics of a uniform grain, with strict control of final humidity of the granules and relatively short process when compared to other techniques for drugs production. Metformin is a drug displayed as hydrochloride and orally administered as coated tablets. It is indicated for the treatment of type 2 Diabetes mellitus. In order to improve productivity in an industrial fluidized bed used in the granulation and drying of Metformin, it is necessary to evaluate the effects of operation conditions used in the process, as particulate material and in the production process. For that purpose, it was performed the study of fluiddynamic granulation and drying of Metformin in fluidized bed in order to investigate the minimum fluidization velocity for the process of this drug. The influence of temperature and speed of drying air in processing time of the formula, and the average particle size were also evaluated. The experiments were elaborated based on the Evolutionary Operation Theory, proposed by Box (1957). It performed the shaping at drying stage. With these experiments was possible to reduce to zero the reworks of batches caused by the formation of preferential channels, which could occur deposition polymer solution on the particulate material. It was also possible to reduce the average processing time in 8 minutes, adding greater productivity and savings for the company where the work was developed. The results achieved, besides the gain in productivity, guide to where efforts should be directed to continue improving productivity, providing a practical methodology for applying the technique that can be applied in the production of other drugs that use the granulation process in fluidized bed.
A administração de fármacos para efeitos sistêmicos por via oral é a forma mais comum dentre os medicamentos. Dentre estes, os medicamentos na forma de comprimidos são os mais empregados. A granulação é um processo que visa melhorar o transporte do pó na máquina compressora por meio da aglomeração de partículas. A secagem em leito fluidizado acoplado à técnica de spray dryer é a técnica comumente empregada para a formação de grânulos que atendam as características necessárias de granulometria uniforme, com controle rigoroso da umidade final do granulado e tempo relativamente curto de processo quando comparado a outras técnicas para produção de medicamentos. A metformina é um fármaco, apresentado na forma de cloridrato, e administrado como comprimidos revestidos por via oral. É indicado no tratamento de diabetes, mais especificamente diabetes mellitus tipo 2. Com o objetivo de aprimorar a produtividade em um leito fluidizado industrial utilizado na granulação e secagem de metformina, faz-se necessário avaliar os efeitos das condições operacionais utilizadas no processo referentes a qualidade material particulado e o processo de produção propriamente dito. Para tanto, realizou-se o estudo fluidodinâmico da granulação e secagem de metformina em leito fluidizado investigando assim a velocidade mínima de fluidização para o processamento deste fármaco. A influência da temperatura e da velocidade do ar de secagem no tempo de processamento da fórmula e no tamanho médio da partícula também foram avaliados. Os experimentos foram elaborados a partir da teoria da Operação Evolutiva, proposta por Box (1957). A modelagem da etapa de secagem também foi realizada. Por meio dos experimentos realizados conseguiu-se reduzir a zero os reprocessos de bateladas por formação de canais preferenciais, onde poderia ocorrer deposição de solução polimérica sobre o material particulado. Foi possível também reduzir o tempo médio de processamento em 8 minutos, agregando maior produtividade e economia para a empresa na qual este trabalho foi desenvolvido. Os resultados obtidos mostram que houve ganhos em relação a produtividade, e norteiam para onde os esforços devem ser direcionados para continuidade do melhoramento de produtividade, fornecendo uma metodologia prática para aplicação da técnica que poderá ser aplicada na produção de outros fármacos que utilizam o processo de granulação por via úmida em leito fluidizado.
Strouhal, Jiří. "Pokročilé výpočtové metody spalování tuhých paliv." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-403867.
Full textCatelam, Kelly Tafari. "Estudo da influência da proporção de um "mix" leite/popa da marcacujá na produção de pó obtido por três diferentes tipos de secagem /." São José do Rio Preto : [s.n.], 2010. http://hdl.handle.net/11449/90758.
Full textAbstract: The aim of this research was to study the influence of different drying methods (pulsed fluid bed dryer, spray dryer and freeze dryer) of passion fruit pulp in the quality of final powder product. All these processes have the purpose to obtain a powder product, showing advantages and disadvantages in terms of handmade and costs. Nonetheless, the literature has a few studies related to comparison between these processes, focusing final product quality. Skim milk was utilized to evaluate its efficiency on partial substitution of additives commonly used in this kind of processes like maltodextrin and Arabic gum, which have the function of minimizing technologies difficulties in drying fruit juices and other products with high quantity of sugar due to hygroscopicity and termoplasticity in high temperatures and humidity. Initially, physicochemical analysis of passion fruit pulp and skim milk showed values close to those described by literature, with little differences due to passion fruit varieties used, time and place of culture. For skim milk the differences can be explain due to existence of a lot of commercial marks. Drying of passion fruit pulp without additives in many operations conditions had a small yield, becoming process impracticable in these conditions. It was obtained powdered passion fruit and additives in spray dryer. Using maltodextrin the greater yield (23.32%) was obtained for 1:4:4 ratio (passion fruit pulp:maltodextrin:skim milk) that is 50% of solids from additives substituted by skim milk. To Arabic gum the best results (21.96%) was obtained to 1:2:6 (passion fruit pulp:Arabic gum:skim milk) with 75% of solids from additives substituted by skim milk. The total substitution of additives (maltodextrin or Arabic gum) by skim milk also showed good results (15.5%). These better yield were obtained in 120°C and feed flow 0.4 l/h considering ratio of pulp... (Complete abstract click electronic access below)
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Books on the topic "Fluid bed drying"
Weyell, Manfred. Pre-drying of biomass using a vibrating fluid-bed drying system as a preliminary stage of biomass pyrolysis. Luxembourg: Commission of the European Communities, 1985.
Find full textBook chapters on the topic "Fluid bed drying"
Liu, Dalu, and Linyou Wu. "Studies on Drying Pullulan by Using Spray-Fluid-Bed with Carriers Circulation." In Biochemical Engineering for 2001, 166–69. Tokyo: Springer Japan, 1992. http://dx.doi.org/10.1007/978-4-431-68180-9_42.
Full textSahu, Pramod Kumar, Amrita Gupta, Megha Singh, Priyam Mehrotra, and G. P. Brahmaprakash. "Bioformulation and Fluid Bed Drying: A New Approach Towards an Improved Biofertilizer Formulation." In Eco-friendly Agro-biological Techniques for Enhancing Crop Productivity, 47–62. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-6934-5_3.
Full textChristelle, Turchiuli, and Dumoulin Elisabeth. "Aroma Encapsulation in Powder by Spray Drying, and Fluid Bed Agglomeration and Coating." In Food Engineering Series, 255–65. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-7906-2_14.
Full textChristelle, Turchiuli, and Dumoulin Elisabeth. "Erratum To: Chapter 14 Aroma Encapsulation in Powder by Spray Drying, and Fluid Bed Agglomeration and Coating." In Food Engineering Series, E1. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-7906-2_33.
Full textHaide, Robert, and Maurizio Santini. "Use of X-ray Micro Computed Tomography for the Investigation of Drying and Salt Precipitation in a Regular Glass Bead Structure." In Fluid Mechanics and Its Applications, 87–100. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33338-6_7.
Full text"Spray-Fluid Bed–Vibrated Fluid Bed Dryer." In Advanced Drying Technologies, Second Edition, 375–77. CRC Press, 2009. http://dx.doi.org/10.1201/9781420073898.ch28.
Full text"Continuous Fluid-Bed Drying." In Drying in the Process Industry, 67–97. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118105818.ch5.
Full textParikh, Dilip M. "Drying." In How to Optimize Fluid Bed Processing Technology, 55–63. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-804727-9.00006-5.
Full textGupta, R. "Fluid bed granulation and drying." In Predictive Modeling of Pharmaceutical Unit Operations, 137–58. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-08-100154-7.00006-5.
Full textDevahastin, Sakamon, and Arun Mujumdar. "Applications for Fluidized Bed Drying." In Handbook of Fluidization and Fluid-Particle Systems. CRC Press, 2003. http://dx.doi.org/10.1201/9780203912744.ch18.
Full textConference papers on the topic "Fluid bed drying"
Kemp, Ian C., Alex Van Millingen, Houda Khaled, and Lewis Iler. "Simultaneous wetting and drying; fluid bed granulation and tablet film coating." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7931.
Full textNITZ, MARCELLO, and OSVALDIR PEREIRA TARANTO. "THE INFLUENCES OF PROCESS VARIABLES ON THE DRYING OF A POROUS MATERIAL IN A PULSED FLUID BED." In The Proceedings of the 5th Asia-Pacific Drying Conference. World Scientific Publishing Company, 2007. http://dx.doi.org/10.1142/9789812771957_0025.
Full textYan, Junjie, Ming Liu, Shan Wang, Rongtang Liu, and Xiaoqu Han. "The consumption of exergy for lignite drying with different technologies: a comparative theoretical study." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7372.
Full textVaccari, Anna, Michele Pinelli, Luca Pirani, and Nicola Gandolfi. "CFD Analysis of a Fluidized Bed Reactor for Industrial Application." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37042.
Full textSharma, Avdhesh K., M. R. Ravi, and S. Kohli. "Modelling Conduction and Radiation in the Reactive Porous Bed of the Gasifier." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80758.
Full textCristea, Eugen-Dan, Luca Sarandrea, and Massimo Galbiati. "CFD Modeling for Optimizing the Fluid Dynamics Patterns of Refractory Lining Drying Process in a Vertical Lime Kiln." In ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting collocated with the ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/fedsm2014-21125.
Full textWard, John, Roy Garwood, Randall Bowen, Maurice Fisher, and David Gent. "Design and Development of an Improved Air Distributor for a Large Coal-Fired Fluidised Bed Combustor." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67224.
Full textAmritkar, Amit Ravindra, Danesh Tafti, and Surya Deb. "Particle Scale Heat Transfer Analysis in Rotary Kiln." In ASME 2012 Heat Transfer Summer Conference collocated with the ASME 2012 Fluids Engineering Division Summer Meeting and the ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/ht2012-58137.
Full textAchariyaviriya, Aree, and Paradorn Nuthong. "Effects of Drying Conditions of Fixed Bed Longan Drying on Optimal Bed Thickness." In ASME/JSME 2007 5th Joint Fluids Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/fedsm2007-37206.
Full textSchubert, Frank, and Ian Parkinson. "Renewable Energy and Water System (REWS) at Musco Family Co. Olive Plant." In ASME 2009 3rd International Conference on Energy Sustainability collocated with the Heat Transfer and InterPACK09 Conferences. ASMEDC, 2009. http://dx.doi.org/10.1115/es2009-90315.
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