Log in

Relevant bibliographies by topics / Fluid bed granulation and drying / Journal articles

To see the other types of publications on this topic, follow the link: Fluid bed granulation and drying.

Journal articles on the topic 'Fluid bed granulation and drying'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Fluid bed granulation and drying.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kim, Kang Min, and Jae Sung Pyo. "A STUDY OF FLUID BED GRANULATION OF PRAVASTATIN TABLET USING DESIGN OF EXPERIMENTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (October 7, 2018): 410. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27356.

Full text

Abstract:

Objective: The objective of this study was to reduce size and weight of pravastatin tablet through quality by design approach; potential factors (spray rate, atomizing pressure, and inlet temperature) which could influence on the production process for critical process parameters of wet granulation using fluid-bed granulator were examined.Methods: The manufacturing process of the reduced weight and size formulation pravastatin tablet involves wet granulation, drying, granulate screening, blending, and tableting. Design of experiments study for wet granulation of the reduced weight/size pravastatin tablet was produced on 11 combinations of three factors (spray rate, atomizing pressure, and inlet temperature), which were chosen through initial risk assessment. The process of wet granulation was rated by measuring four responses: loss on drying (LOD) (%), bulk density (g/ml), product temperature (°C), and dissolution similarity (f2).Results: It was measured that LOD varied from 1.46 to 3.24%, bulk density from 0.34 to 0.51 g/ml, product temperature from 40.12 to 51.69°C, and dissolution (f2) of pravastatin from 52.14 to 58.91. Control strategy for wet granulation production of the reduced weight and size pravastatin tablet by our results demonstrated that the most optimized condition of three factors for wet granulation is spray rate (3–5 g/min), atomizing pressure (about 1 bar), and inlet temperature (65–90°C), respectively. Updated risk assessment and justification by all experimental data safely existed within the range of acceptance criteria were presented.Conclusion: It can be concluded that the ideal ranges of three factors (spray rate, atomizing pressure, and inlet temperature) in wet granulation were successfully identified.

APA, Harvard, Vancouver, ISO, and other styles

2

Bozkurt, Semra, Özgül Altay, Mehmet Koç, and Figen Kaymak Ertekin. "Toz Gıda Proseslerinde Akışkan Yatak Uygulamaları." Turkish Journal of Agriculture - Food Science and Technology 8, no. 4 (April 25, 2020): 818–25. http://dx.doi.org/10.24925/turjaf.v8i4.818-825.2861.

Full text

Abstract:

Fluidized bed system has a wide range of use from heavy industry to pharmaceutical, chemical and food industry. In this system, a bed of solid particles is transformed into a fluid-like state through suspension in a fluid. The minimum fluidization rate, defined as the speed at which the fluidization begins at the bed, is the most important design and operation parameter of the fluidized bed systems. Fluidized bed in powdered foods are widely used for drying, agglomeration, granulation and coating processes. Since many events take place simultaneously in fluidized bed technology, there are many variables acting on the system. In this review, information is given about fluid bed, fluidized bed applications in powder food processes and parameters to be considered during the use of fluidized bed system.

APA, Harvard, Vancouver, ISO, and other styles

3

Hlinak, Anthony J., and Azita Saleki-Gerhardt. "An Evaluation of Fluid Bed Drying of Aqueous Granulations." Pharmaceutical Development and Technology 5, no. 1 (January 2000): 11–17. http://dx.doi.org/10.1081/pdt-100100514.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Djuriš, Jelena, Djordje Medarević, Marko Krstić, Ivana Vasiljević, Ivana Mašić, and Svetlana Ibrić. "Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process." Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/185085.

Full text

Abstract:

The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design. Type of diluent and atomization pressure were selected as the most important parameters. In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed. Percent of paracetamol released and tablets hardness were determined as critical quality attributes. Artificial neural networks (ANNs) were applied in order to determine design space. ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness. Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors.

APA, Harvard, Vancouver, ISO, and other styles

5

Rehrl, Jakob, Stephan Sacher, Martin Horn, and Johannes Khinast. "End-Point Prediction of Granule Moisture in a ConsiGmaTM-25 Segmented Fluid Bed Dryer." Pharmaceutics 12, no. 5 (May 14, 2020): 452. http://dx.doi.org/10.3390/pharmaceutics12050452.

Full text

Abstract:

Continuously operated pharmaceutical manufacturing lines often consist of a wet granulation unit operation, followed by a (semi-) continuous dryer. The operating conditions of the dryer are crucial for obtaining a desired final granule moisture. Commercially available dryers lack of a thorough online measurement of granule moisture during the drying process. However, this information could improve the operation of the equipment considerably, yielding a granule moisture close to the desired value (e.g., by drying time and process parameter adjustments in real-time). The paper at hand proposes a process model, which can be parameterized from a very limited number of experiments and then be used as a so-called soft sensor for predicting granule moisture. It utilizes available process measurements for the estimation of the granule moisture. The development of the model as well as parameter identification and validation experiments are provided. The proposed model paves the way for the application of sophisticated observer concepts. Possible future activities on that topic are outlined in the paper.

APA, Harvard, Vancouver, ISO, and other styles

6

Duarte, Claudio Roberto, Valéria V. Murata, and Marcos A. S. Barrozo. "Simulation of Spouted Bed Using a Eulerian Multiphase Model." Materials Science Forum 498-499 (November 2005): 270–77. http://dx.doi.org/10.4028/www.scientific.net/msf.498-499.270.

Full text

Abstract:

Spouted bed systems have emerged as very efficient fluid-particle contactors and find many applications in the chemical and biochemical industry. Some important applications of spouted beds include coal combustion, biochemical reactions, drying of solids, drying of solutions and suspensions, granulation, blending, grinding, and particle coating. An extensive overview can be found in Mathur and Epstein[1]. The pattern of solid and gas flows in a spouted bed was numerically simulated using a CFD modeling technique. The Eulerian-Eulerian multifluid modeling approach was applied to predict gas-solid flow behavior. A commercially available, control-volume-based code FLUENT 6.1 was chosen to carry out the computer simulations. In order to reduce computational times and required system resources, the 2D axisymmetric segregated solver was chosen. The typical flow pattern of the spouted bed was obtained in the present calculation. The simulated velocity and voidage profiles presented a good agreement qualitative and quantitative with the experimental results obtained by He et al. [4].

APA, Harvard, Vancouver, ISO, and other styles

7

Araújo, Bruna Sene Alves, and Kássia Graciele dos Santos. "CFD Simulation of Different Flow Regimes of the Spout Fluidized Bed with Draft Plates." Materials Science Forum 899 (July 2017): 89–94. http://dx.doi.org/10.4028/www.scientific.net/msf.899.89.

Full text

Abstract:

Spout fluidized bed has shown promising for gas-solid contact operations with and without chemical reactions, such as drying, coating, granulation, gasification, pyrolysis, etc. This is because these beds combine features from both spouted and fluidized beds. The other point is the ability to treat chemical transformations involving both heat and mass transfer in combination with particles of various sizes. Therefore, it is extremely important the knowledge of fluid dynamic of the bed, mainly for scale-up projects, which makes computer simulation an essential tool. Researches using the Computation Fluid Dynamics (CFD) proved to be very effective in predicting of particles dynamic in this type of bed. In Computation Fluid Dynamics, the two phases are treated as interpenetration continuous, and these phases are described by equations of conservation of mass, momentum and energy. The goal of the present work was to simulate using CFD experimental fluid dynamics data of a spout fluidized bed. Eight distinct flow regimes were identified which showed up in good agreement with the regime map presented in literature. The results showed that the technique was efficient for the simulation of the hydrodynamic of the bed presented.

APA, Harvard, Vancouver, ISO, and other styles

8

Silva, A. F., M. C. Sarraguça, M. Fonteyne, J. Vercruysse, F. De Leersnyder, V. Vanhoorne, N. Bostijn, et al. "Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process." International Journal of Pharmaceutics 528, no. 1-2 (August 2017): 242–52. http://dx.doi.org/10.1016/j.ijpharm.2017.05.075.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Menth, Judith, Martin Maus, and Karl G. Wagner. "Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties." International Journal of Pharmaceutics 586 (August 2020): 119509. http://dx.doi.org/10.1016/j.ijpharm.2020.119509.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ryckaert, Alexander, Michael Ghijs, Christoph Portier, Dejan Djuric, Adrian Funke, Chris Vervaet, and Thomas De Beer. "The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation." Pharmaceutics 13, no. 2 (February 23, 2021): 293. http://dx.doi.org/10.3390/pharmaceutics13020293.

Full text

Abstract:

The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during, and after the fluid bed drying process is, however, still lacking. A first major goal was to investigate the breakage and attrition phenomena during transport of wet and dry granules, the filling phase, and drying phase on a ConsiGma-25 system (C25). Pneumatic transport of the wet granules after TSG towards the dryer induced extensive breakage, whereas the turbulent filling and drying phase of the drying cells caused rather moderate breakage and attrition. Subsequently, the dry transfer line was responsible for additional extensive breakage and attrition. The second major goal was to compare the influence of drying air temperature and drying time on granule size and moisture content for granules processed with a commercial-scale ConsiGma-25 system and with the R&D-scale ConsiGma-1 (C1) system. Generally, the granule quality obtained after drying with C1 was not predictive for the C25, making it challenging during process development with the C1 to obtain representative granules for the C25.

APA, Harvard, Vancouver, ISO, and other styles

11

Sanzida, Nahid. "Determination of Optimum Drying Temperature Profile by Iterative Learning Control (ILC) Method to Obtain a Desired Moisture Content in Tablets." Chemical Engineering Research Bulletin 20, no. 1 (June 6, 2018): 1. http://dx.doi.org/10.3329/cerb.v20i1.36923.

Full text

Abstract:

<p>The paper presents an industrial case study example to evaluate the performance of the linear time varying (LTV) perturbation model based iterative learning control (ILC) in a pilot scale batch system. The operating data based strategy applied here is based on utilizing the repetitive nature of batch processes to update the operating trajectories using process knowledge obtained from previous runs and thereby providing a convergent batch-to-batch improvement of the process performance indicator. The method was applied to determine the required drying temperature of Paracetamol granules to obtain desired moisture content at the end of the batch. After granulation operations, Paracetamol granules were dried in a fluid bed dryer in the pilot plant laboratory of GlaxoSmithKline Bangladesh Limited, Chittagong, Bangladesh. These results demonstrate the potential of the ILC approach for controlling batch processes without rigorous process models.</p><p>Chemical Engineering Research Bulletin 20(2018) 1-7</p>

APA, Harvard, Vancouver, ISO, and other styles

12

Reddy, Sunitha M., and Sravani Baskarla. "A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (June 1, 2021): 5519–228. http://dx.doi.org/10.37285/ijpsn.2021.14.4.1.

Full text

Abstract:

This article describes current strategies to enhance aqueous solubility and dissolution rate of poor soluble drugs. Most drugs in the market are lipophilic with low or poor water solubility. There are various methods to enhance solubility: co-solvency, particle size reduction, salt formation and Self Nanoemulsifying drug delivery systems, SEDDS is a novel approach to enhance solubility, dissolution rate and bioavailability of drugs. The study involves formulation and evaluation of solid self-Nano emulsifying drug delivery system (S-SNEDDS) to enhance aqueous solubility and dissolution rate. Oral route is the most convenient route for non-invasive administration. S-SNEDDS has more advantages when compared to the liquid self-emulsifying drug delivery system. Excipients were selected depends upon the drug compatibility oils, surfactants and co surfactants were selected to formulate Liquid SNEDDS these formulated liquid self-nano emulsifying drug delivery system converted into solid by the help of porous carriers, Melted binder or with the help of drying process. Conversion process of liquid to solid involves various techniques; they are spray drying; freeze drying and fluid bed coating technique; extrusion, melting granulation technique. Liquid SNEDDS has a high ability to improve dissolution and solubility of drugs but it also has disadvantages like incompatibility, decreased drug loading, shorter shelf life, ease of manufacturing and ability to deliver peptides that are prone to enzymatic hydrolysis.

APA, Harvard, Vancouver, ISO, and other styles

13

Pauli, Victoria, Frantz Elbaz, Peter Kleinebudde, and Markus Krumme. "Methodology for a Variable Rate Control Strategy Development in Continuous Manufacturing Applied to Twin-screw Wet-Granulation and Continuous Fluid-bed Drying." Journal of Pharmaceutical Innovation 13, no. 3 (April 25, 2018): 247–60. http://dx.doi.org/10.1007/s12247-018-9320-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Mazova, N. V., A. L. Marchenko, and I. E. Smehova. "Research and Development of the Composition and Technology Receving of Granules of Omeprazol in the Fluid Bed Apparatus." Drug development & registration 8, no. 2 (May 30, 2019): 74–79. http://dx.doi.org/10.33380/2305-2066-2019-8-2-74-79.

Full text

Abstract:

Introduction. In this research is devoted to questions of development of structure and technology of granules of an omeprazole. It is established that the most optimal dosage form for medicines of inhibitors of a proton pump is considered to be the tablet with a multiple-unit pellets system (microparticles). In this case of the production of these medicines in the microgranules of a particle are covered with several protective covers. For development of microgranules of an omeprazole is offered the technology of lamination in the fluid bed apparatus.Aim. To receive in the fluid bed apparatus of the microgranules of an omeprazole covered with the enteric cover.Materials and methods. To solve this problem technical characteristics on the granulates of an omeprazole received at various operating modes of the fluid bed apparatus are defined such as form of granules, fractional structure and bulk density are determined by the methods described by the State Pharmacopeia of the XIII edition.Results and discussion. As a result of a research the choice of polymers for layered deposition in the granulation process of a substance of omeprazole is substantiated. Produced selection of enteric polymer of various firms of producers is made for providing a necessary profile of release of an omeprazole in a human body. A copolymer of methacrylic acid – Kollicoat MAE 100 P is chosen. Special attention is paid to receiving the enteric granules of an omeprazole of the correct spherical form with minimum roughness and the improved flowability for further tabletting. For the purpose of receiving granules of an omeprazole of a spherical form selection of an optimum operating mode of the device of a fluid bed apparatus is made for implementation of process of applying the enteric polymer. Following the results of experiments the dependence of quality of fractional structure and appearance of granules of an omeprazole on temperature, pressure and feed rate of polymer is defined. Besides, it is established that the uniformity of application and thickness of a layer of the applied enteric polymer on granules of an omeprazole depend not only on the polymer feed rate, but also on the size of drops of the feed solution.Conclusion. It is established that the quality of the granules of an omeprazole received the enteric polymer was affected by such factors of technological parameters of the fluid bed apparatus as: temperature of the entering air in the apparatus, the air pressure upon a nozzle, air pressure upon a gas-distributing grid of the apparatus, speed of the given polymer, a lot of loading of granules, air temperature of a layer of granules, duration of drying of granules upon termination of process of application of the enteric polymer.

APA, Harvard, Vancouver, ISO, and other styles

15

Giry, K., M. Viana, M. Genty, F. Louvet, P. Wüthrich, and D. Chulia. "Comparison of single pot and multiphase granulation. Part 2: Effect of the drying process on granules manufactured in a single pot granulator and dried either in situ or in a fluid bed dryer." Pharmaceutical Development and Technology 14, no. 2 (April 2009): 149–58. http://dx.doi.org/10.1080/10837450802588942.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Grohn, Philipp, Marius Lawall, Tobias Oesau, Stefan Heinrich, and Sergiy Antonyuk. "CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator." Processes 8, no. 9 (September 2, 2020): 1090. http://dx.doi.org/10.3390/pr8091090.

Full text

Abstract:

Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round, coated pellets. In this work, the coating process in a rotor granulator is investigated numerically using computational fluid dynamics (CFD) coupled with the discrete element method (DEM). The droplets are generated as a second particulate phase in DEM. A liquid bridge model is implemented in the DEM model to take the capillary and viscous forces during the wet contact of the particles into account. A coating model is developed, where the drying of the liquid layer on the particles, as well as the particle growth, is considered. The simulation results of the dry process compared to the simulations with liquid injection show an important influence of the liquid on the particle dynamics. The formation of liquid bridges and the viscous forces in the liquid layer lead to an increase of the average particle velocity and contact time. Changing the injection rate of water has an influence on the contact duration but no significant effect on the particle dynamics. In contrast, the aqueous binder solution has an important influence on the particle movement.

APA, Harvard, Vancouver, ISO, and other styles

17

Van Hauwermeiren, Daan, Michiel Stock, Thomas De Beer, and Ingmar Nopens. "Predicting Pharmaceutical Particle Size Distributions Using Kernel Mean Embedding." Pharmaceutics 12, no. 3 (March 16, 2020): 271. http://dx.doi.org/10.3390/pharmaceutics12030271.

Full text

Abstract:

In the pharmaceutical industry, the transition to continuous manufacturing of solid dosage forms is adopted by more and more companies. For these continuous processes, high-quality process models are needed. In pharmaceutical wet granulation, a unit operation in the ConsiGma TM -25 continuous powder-to-tablet system (GEA Pharma systems, Collette, Wommelgem, Belgium), the product under study presents itself as a collection of particles that differ in shape and size. The measurement of this collection results in a particle size distribution. However, the theoretical basis to describe the physical phenomena leading to changes in this particle size distribution is lacking. It is essential to understand how the particle size distribution changes as a function of the unit operation’s process settings, as it has a profound effect on the behavior of the fluid bed dryer. Therefore, we suggest a data-driven modeling framework that links the machine settings of the wet granulation unit operation and the output distribution of granules. We do this without making any assumptions on the nature of the distributions under study. A simulation of the granule size distribution could act as a soft sensor when in-line measurements are challenging to perform. The method of this work is a two-step procedure: first, the measured distributions are transformed into a high-dimensional feature space, where the relation between the machine settings and the distributions can be learnt. Second, the inverse transformation is performed, allowing an interpretation of the results in the original measurement space. Further, a comparison is made with previous work, which employs a more mechanistic framework for describing the granules. A reliable prediction of the granule size is vital in the assurance of quality in the production line, and is needed in the assessment of upstream (feeding) and downstream (drying, milling, and tableting) issues. Now that a validated data-driven framework for predicting pharmaceutical particle size distributions is available, it can be applied in settings such as model-based experimental design and, due to its fast computation, there is potential in real-time model predictive control.

APA, Harvard, Vancouver, ISO, and other styles

18

Kim, Kim, Lim, Kim, Yong, Choi, and Jin. "Comparison of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol-Loaded Self-Emulsifying Granule and Solid Self-Nanoemulsifying Drug Delivery System: Powder Property, Dissolution and Oral Bioavailability." Pharmaceutics 11, no. 8 (August 16, 2019): 415. http://dx.doi.org/10.3390/pharmaceutics11080415.

Full text

Abstract:

The main objective of this study was to compare the powder property, dissolution and bioavailability of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG)-loaded self-emulsifying granule system (SEGS) and solid self-nanoemulsifying drug delivery system (SNEDDS). Various SEGS formulations were prepared, and the effect of surfactant and binder on the drug solubility in them, leading to selecting sodium lauryl sulphate (SLS) and hydroxyl propyl methyl cellulose (HPMC). The SEGS and SNEDDS were prepared with PLAG/SLS/HPMC/calcium silicate/microcrystalline cellulose at the weight ratio of 1:0.25:0.1:0.5:3 employing the fluid bed granulation and spray-drying technique, respectively. Their powder properties were compared in terms of flow ability, emulsion droplet size, scanning electron microscopy, and powder X-ray diffraction. Furthermore, the solubility, dissolution, and oral bioavailability in rats of the SEGS were assessed in comparison with the SNEDDS. The SEGS and SNEDDS enhanced the solubility of the drug approximately 36- and 32-fold as compared with the drug alone; but they had no differences. The crystalline drug may exist in both the calcium silicate and microcrystalline cellulose (MCC) in the SEGS, but only in the calcium silicate in the SNEDDS. The SEGS had considerably improved the flow ability (Hausner ratio, 1.23 vs. 1.07; Carr index, 19.8 vs. 43.5%) and drug dissolution as compared with the SNEDDS. The SEGS and SNEDDS with double peak profiles, unlike the single peak of drug alone, showed a significantly higher plasma concentration and area under the curve (AUC), as compared with drug alone. Although they were not significantly different, the SEGS gave higher AUC than did the SNEDDS, suggesting its enhanced oral bioavailability of PLAG. Thus, the SEGS could be used as a powerful oral dosage form to improve the flow ability and oral bioavailability of PLAG, an oily drug.

APA, Harvard, Vancouver, ISO, and other styles

19

Haldar, R., B. Gangadharan, D. Martin, and A. Mehta. "Fluid Bed Granulation of Ibuprofen." Drug Development and Industrial Pharmacy 15, no. 14-16 (January 1989): 2675–79. http://dx.doi.org/10.3109/03639048909052553.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Cryer, Steven A. "Modeling agglomeration processes in fluid-bed granulation." AIChE Journal 45, no. 10 (October 1999): 2069–78. http://dx.doi.org/10.1002/aic.690451005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Muddu, Shashank, Ashutosh Tamrakar, Preetanshu Pandey, and Rohit Ramachandran. "Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology." Processes 6, no. 9 (September 1, 2018): 154. http://dx.doi.org/10.3390/pr6090154.

Full text

Abstract:

An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composition in the formulation. A population balance model framework integrated with heat transfer and moisture balance due to liquid addition and evaporation was developed to simulate the fluid bed granulation system. The model predictions were compared with the industry data, namely, the particle size distributions (PSDs) and geometric mean diameters (GMDs) at various time-points in the granulation process. The model also predicted the trends for binder particle dissolution in the wetting liquid and the temperatures of the bed particles in the fluid bed granulator. Lastly, various process parameters were varied and extended beyond the region studied in the aforementioned experimental study to identify optimal regimes for granulation.

APA, Harvard, Vancouver, ISO, and other styles

22

Suresh, P., N. Saketharam Reddy, R. Hariharan, and I. Sreedhar. "Studies on Fluid bed Granulation of Lactose-MCC mixture." Materials Today: Proceedings 24 (2020): 519–30. http://dx.doi.org/10.1016/j.matpr.2020.04.305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Flögel, S., and H. Egermann. "Fluid bed granulation of lactose using botton spray method." European Journal of Pharmaceutical Sciences 4 (September 1996): S185. http://dx.doi.org/10.1016/s0928-0987(97)86569-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Rantanen, Jukka T., Sampsa J. Laine, Osmo K. Antikainen, Jukka-Pekka Mannermaa, Olli E. Simula, and Jouko K. Yliruusi. "Visualization of fluid-bed granulation with self-organizing maps." Journal of Pharmaceutical and Biomedical Analysis 24, no. 3 (January 2001): 343–52. http://dx.doi.org/10.1016/s0731-7085(00)00458-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Dahl, Terrence C., and Andreas P. Bormeth. "Naproxen Controlled Release Matrix Tablets: Fluid Bed Granulation Feasibility." Drug Development and Industrial Pharmacy 16, no. 4 (January 1990): 581–90. http://dx.doi.org/10.3109/03639049009104404.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Dahl, Terrence C., and Andreas P. Bormeth. "Naproxen Controlled Release Matrix Tablets: Fluid Bed Granulation Feasibility." Drug Development and Industrial Pharmacy 16, no. 3 (January 1990): 581–90. http://dx.doi.org/10.3109/03639049009114904.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Cryer, S. A., and P. N. Scherer. "Observations and process parameter sensitivities in fluid-bed granulation." AIChE Journal 49, no. 11 (November 2003): 2802–9. http://dx.doi.org/10.1002/aic.690491113.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Behzadi, Sharareh Salar, Johanna Klocker, Herbert Hüttlin, Peter Wolschann, and Helmut Viernstein. "Validation of fluid bed granulation utilizing artificial neural network." International Journal of Pharmaceutics 291, no. 1-2 (March 2005): 139–48. http://dx.doi.org/10.1016/j.ijpharm.2004.07.051.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Emenike, Victor N., Ivonne Kulla, Martin Maus, Andrea Staab, and Daniela Schröder. "A linear scale-up approach to fluid bed granulation." International Journal of Pharmaceutics 598 (April 2021): 120209. http://dx.doi.org/10.1016/j.ijpharm.2021.120209.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Dernedde, M., M. Peglow, and E. Tsotsas. "Stochastic Modeling of Fluidized Bed Granulation: Influence of Droplet Pre-Drying." Chemical Engineering & Technology 34, no. 7 (June 15, 2011): 1177–84. http://dx.doi.org/10.1002/ceat.201100052.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Temple, S. J., and A. J. B. van Boxtel. "Control of Fluid Bed Drying of Tea." IFAC Proceedings Volumes 31, no. 9 (June 1998): 37–41. http://dx.doi.org/10.1016/s1474-6670(17)44025-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Groenewold, H., and E. Tsotsas. "A NEW MODEL FOR FLUID BED DRYING." Drying Technology 15, no. 6-8 (July 1997): 1687–98. http://dx.doi.org/10.1080/07373939708917318.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Moreno, Rogelio, and José Oyarzo. "SAWDUST FLUID-BED DRYING WITH HEATING TUBES." Drying Technology 16, no. 1-2 (January 1998): 351–67. http://dx.doi.org/10.1080/07373939808917410.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Breitenbach, Jutta, Christopher Beermann, and Günter J. Esper. "Comparison of different methods for microencapsulation of probiotics." Progress in Agricultural Engineering Sciences 12, no. 1 (December 2016): 63–80. http://dx.doi.org/10.1556/446.12.2016.4.

Full text

Abstract:

At the Department of Food Technology at Fulda University of Applied Sciences different methods for microencapsulation of Lactobacillus reuteri DSM 20016 were investigated. The aim of these studies was to develop a process to stabilize the probiotic bacteria for storage and to prevent them from the gastric conditions, to ensure that a satisfactory amount of the probiotics could reach their target location, the human intestine. Drying processes like spray drying and freeze drying were tested as well as fluidized bed granulation with optional Wurster coating using different auxiliary materials. As encapsulation material maltodextrine, sweet whey powder or gummi arabicum were used. The coating experiments were performed with an aqueous shellac solution. In the performed studies the fluidized bed bottom spray granulation with an additional Wurster coating turned out to be an encouraging procedure to keep the probiotics in a stable form resistant against gastric conditions. The survival rate in the simulated gastro-intestinal passage could be increased up to the sevenfold amount of the untreated bacteria.

APA, Harvard, Vancouver, ISO, and other styles

35

Akhtaruzzaman, M., MR Ali, MM Rahman, and MS Ahamed. "Drying tea in a kilburn vibro fluid bed dryer." Journal of the Bangladesh Agricultural University 11, no. 1 (March 5, 2014): 153–58. http://dx.doi.org/10.3329/jbau.v11i1.18227.

Full text

Abstract:

The fluidized bed drying principles for drying of tea in Bangladesh is thoroughly studied. The experiments were conducted to determine the drying curve, drying time, drying constant and dynamic equilibrium moisture contents of tea at the Bangladesh Tea Research Institute. Drying of tea in a fluidized bed dryer (Kilburn Vibro Fluid Bed Dryer) takes only 20 min for drying from an initial moisture content of 69.1% to a final moisture content of 2.8%. Temperatures of drying air were recorded to be 130°C at the inlet and 90°C at the outlet. The drying constant was found to be 31.05 h-1 and the dynamic equilibrium moisture contents were in the range of 18.3 to 2.0%. Finally the principle of fluidized bed drying was compared with the principle of conventional endless chain pressure type drying. DOI: http://dx.doi.org/10.3329/jbau.v11i1.18227 J. Bangladesh Agril. Univ. 11(1): 153-158, 2013

APA, Harvard, Vancouver, ISO, and other styles

36

Rieck, C., T. Hoffmann, A. Bück, M. Peglow, and E. Tsotsas. "Influence of drying conditions on layer porosity in fluidized bed spray granulation." Powder Technology 272 (March 2015): 120–31. http://dx.doi.org/10.1016/j.powtec.2014.11.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

KAWAI, SUMIO. "GRANULATION AND DRYING OF POWDERY OR LIQUID MATERIALS BY FLUIDIZED-BED TECHNOLOGY." Drying Technology 11, no. 4 (January 1993): 719–31. http://dx.doi.org/10.1080/07373939308916860.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Li, Z., J. Kessel, G. Grünewald, and M. Kind. "CFD Simulation on Drying and Dust Integration in Fluidized Bed Spray Granulation." Drying Technology 30, no. 10 (August 2012): 1088–98. http://dx.doi.org/10.1080/07373937.2012.685672.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Abberger, Th, W. Schiocker, and H. Egermann. "Estimation of concentration of free moisture in fluid bed granulation." European Journal of Pharmaceutical Sciences 4 (September 1996): S185. http://dx.doi.org/10.1016/s0928-0987(97)86568-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Vreman, A. W., C. E. van Lare, and M. J. Hounslow. "A basic population balance model for fluid bed spray granulation." Chemical Engineering Science 64, no. 21 (November 2009): 4389–98. http://dx.doi.org/10.1016/j.ces.2009.07.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Soppela, Ira, Osmo Antikainen, Niklas Sandler, and Jouko Yliruusi. "On-line monitoring of fluid bed granulation by photometric imaging." European Journal of Pharmaceutics and Biopharmaceutics 88, no. 3 (November 2014): 879–85. http://dx.doi.org/10.1016/j.ejpb.2014.08.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Närvänen, Tero. "Particle size determination during fluid bed granulation—Challenges and opportunities." European Journal of Pharmaceutical Sciences 34, no. 1 (June 2008): S12. http://dx.doi.org/10.1016/j.ejps.2008.02.027.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Benelli, Lucimara, Diego F. Cortés-Rojas, Claudia Regina F. Souza, and Wanderley Pereira Oliveira. "Fluid bed drying and agglomeration of phytopharmaceutical compositions." Powder Technology 273 (March 2015): 145–53. http://dx.doi.org/10.1016/j.powtec.2014.12.022.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Tsotsas, Evangelos. "FROM SINGLE PARTICLE TO FLUID BED DRYING KINETICS." Drying Technology 12, no. 6 (January 1994): 1401–26. http://dx.doi.org/10.1080/07373939408961013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Mitrofanov, Andrey V., Vadim E. Mizonov, Katia Tannous, and Lev N. Ovchinnikov. "THEORETICAL STUDY OF GRANULATION KINETICS IN A BATCH FLUIDIZED BED." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 5 (June 23, 2017): 81. http://dx.doi.org/10.6060/tcct.2017605.5611.

Full text

Abstract:

The objective of the study is to build a simple but informative model to estimate qualitatively the influence of process parameters on granulation kinetics in a batch fluidized bed. A Markov chain approach is used to build the model. The height of fluidized bed reactor is separated into a certain number of perfectly mixed cells, and two parallel chains of such cells are introduced: one chain for original particles and another chain for already granulated particles. The particles can move stochastically along their chains and transit from one chain to another due to their size enlargement during granulation. It is supposed that the granulation itself occurs only in the cell of original particles where a binder suspension is supplied to. The volume of suspension, which enters the cell during the time step, is spread over the original particles that can be covered by the suspension up to their desired size. These particles transit to the neighboring cell of another chain for already granulated particles. Then the both sorts of particles move along their chains according to corresponding matrices of transition probabilities. This “could” model can be easily combined with the Markov chain model of drying in fluidized bed developed in our previous works. The numerical experiments with the developed model allowed qualitative estimating the influence of the process parameters on the granulation kinetics. The existence of the optimum superficial gas velocity that provides the maximum rate of granulation is shown. For citation:Mitrofanov A.V., Mizonov V.E., Tannous K., Ovchinnikov L.N. Theoretical study of granulation kinetics in a batch fluidized bed. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 5. P. 81-87

APA, Harvard, Vancouver, ISO, and other styles

46

Li, Zhen, Matthias Kind, and Gerald Gruenewald. "Modeling Fluid Dynamics and Growth Kinetics in Fluidized Bed Spray Granulation." Journal of Computational Multiphase Flows 2, no. 4 (December 2010): 235–48. http://dx.doi.org/10.1260/1757-482x.2.4.235.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

KIVIKERO, N., M. MURTOMAA, B. INGELBEEN, O. ANTIKAINEN, E. RASANEN, J. MANNERMAA, and A. JUPPO. "Microscale granulation in a fluid bed powder processor using electrostatic atomisation." European Journal of Pharmaceutics and Biopharmaceutics 71, no. 1 (January 2009): 130–37. http://dx.doi.org/10.1016/j.ejpb.2008.07.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Ehlers, Henrik, Anchang Liu, Heikki Räikkönen, Juha Hatara, Osmo Antikainen, Sari Airaksinen, Jyrki Heinämäki, Honxiang Lou, and Jouko Yliruusi. "Granule size control and targeting in pulsed spray fluid bed granulation." International Journal of Pharmaceutics 377, no. 1-2 (July 2009): 9–15. http://dx.doi.org/10.1016/j.ijpharm.2009.04.041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Gao, Julia Z. H., A. Jain, R. Motheram, D. B. Gray, and M. A. Hussain. "Fluid bed granulation of a poorly water soluble, low density, micronized drug: comparison with high shear granulation." International Journal of Pharmaceutics 237, no. 1-2 (April 2002): 1–14. http://dx.doi.org/10.1016/s0378-5173(01)00982-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Temple, S. J., S. T. Tambala, and A. J. B. van Boxtel. "Monitoring and control of fluid-bed drying of tea." Control Engineering Practice 8, no. 2 (February 2000): 165–73. http://dx.doi.org/10.1016/s0967-0661(99)00145-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!