Academic literature on the topic 'Fluor-18'
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Journal articles on the topic "Fluor-18"
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de Beco, V., D. Le Bars, and J. M. Scherrmann. "Le fluor 18 en radiopharmacie." Annales Pharmaceutiques Françaises 66, no. 1 (January 2008): 60–65. http://dx.doi.org/10.1016/j.pharma.2007.12.002.
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Gouveia, Patrícia, Adriana Sá Pinto, Liliana Violante, Sara Nunes, Ricardo Teixeira, Almerinda Petiz, and Luís Hugo Duarte. "18F-FDG PET/CT in Patients with Vulvar and Vaginal Cancer: A Preliminary Study of 20 Cases." Acta Médica Portuguesa 35, no. 3 (March 2, 2022): 170. http://dx.doi.org/10.20344/amp.12510.
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Introduction: Despite the growing evidence supporting the use of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in cervical and ovarian malignant tumours, data on vulvar and vaginal cancer is sparse. Our aim was to assess the role of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in patients with vulvar and vaginal cancer. Material and Methods: A retrospective study was conducted on a cohort of 20 patients with biopsy-proven vulvar (n = 17) and vaginal (n = 3) cancer who performed 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography, between January 2013 and April 2018. We collected the clinical data of all patients, as well as the indication for 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography, its results, and the main lesion maximum standard uptake value (SUVmax). In addition, we correlated the results of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography with other diagnostic modalities, namely histological findings, computed tomography and magnetic resonance imaging. Patients were divided into two groups, one with newly diagnosed disease and another with recurrent disease.Results: Six patients had newly diagnosed disease and 14 had recurrent disease. The main lesion was detected by 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in five out of six patients with newly diagnosed disease and in all 14 patients with recurrent disease. Additional sites of 2-[F-18]-fluor-2-desoxi-D-glucose uptake were identified in inguinal and iliac lymph nodes and in distant lesions. Magnetic resonance imaging and computed tomography were performed in 12 cases. In four patients with recurrent disease, abnormalities (main lesion/ metastatic lymph nodes) identified by 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography were not detected as suspicious by computed tomography.Discussion: In our study, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography identified abnormalities more often than conventional computed tomography scans in recurrent disease. In comparison with histology, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography had a sensitivity of 95% and a positive predictive value of 100% in identifying the primary tumour and the recurrent main lesion. Little data is available regarding the usefulness of 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography in the management of vulvar and vaginal cancers. The existing evidence supports a high accuracy in detecting lymph node metastases and a change of 36.0% - 61.5% in patient management. Our findings reinforce the usefulness of this technique in vulvar and vaginal cancer. Limitations of our study include its retrospective nature and the rareness of both vulvar and vaginal cancer, which leads to a small sample size and few comparative imaging tests.Conclusion: In this preliminary study, 2-[F-18]-fluor-2-desoxi-D-glucose positron emission tomography/computed tomography demonstrated it can be a useful method in patients with vulvar and vaginal cancers, namely in defining the extent of disease and contributing to accurate staging and restaging.
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Manuhara, Godras Jati, Setyaningrum Ariviani, and Dwi Ishartani. "Pengaruh Substitusi Terigu dengan Tepung Komposit Tapioka dan Glukomanan-Karaginan Terhadap Kadar Serat Kasar dan Sifat Sensori Mie Basah." Caraka Tani: Journal of Sustainable Agriculture 22, no. 2 (April 21, 2018): 61. http://dx.doi.org/10.20961/carakatani.v22i2.20564.
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Composite fluor was made from combination of tapiocca and glucomannan-carrageenan in four different composition. The composite fluor for wheat in producing wet noodle. Amylose content of tapiocca provide strong structure of wet noodle, while combination of carrageenan-glucomannan objected to substitute gluten function in building elastic bonding needed in the wet noodle. Increasing of the composite fluor level increased raaw fiber content of wet noodle. Based on sensory analysis, substitution of wheat by the composite fluor decreased intensity of brightness, hardness, unique taste and aroma of wet noodle, but in the other side, retained its elasticity at two level of substitution (18% tapiocca mixed with 2% carrageenan-glucomannan and 19% tapiocca mixed 1% carrageenan-glucomannan).
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Deviliawati, Atma. "complete socialization about vaginal discharge or fluor albus at SMK Bina Jaya Palembang in 2021." Khidmah 3, no. 2 (January 11, 2022): 382–88. http://dx.doi.org/10.52523/khidmah.v3i2.366.
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Adolescence is defined by growth, change, and the presence of new chances, and it is often associated with reproductive health problems. In teenage girls, reproductive organ healthcare is expected to prevent significant problems. Preventing vaginal discharge or fluor albus is one of the aims of treatments of reproductive organs in teenage girls. Vaginal discharge or fluor albus is a discharge from the tiny glands in the vagina and cervix that may or may not smell and lead to a local itching. The causes of vaginal discharge or fluor albus may be normal or physiologic. According to 2012 data from the Indonesian Demographic and Health Survey (IDHS), around 18% of women aged 15-49 years had encountered the vaginal discharge or fluor albus. This socialization has the objective of educating teenage girls about vaginal discharge or fluor albus. The strategy is to provide direct socialization through counseling and leaflet distribution, while also following the health protocols. The activity occurred on july 12, 2021. The results of the socialization obtained data on knowledge about vaginal discharge or fluor albus from 46 students before being given socialization with good knowledge of 15 people (32.6%) and after the socialization, there was an increase in students with good knowledge of vaginal discharge or fluor albus as many as 44 students ( 95.7 percent ). Proves an increase in awareness of vaginal discharge or fluor albus before and after socialization. Suggestions for educators to regularly educate students about reproductive health, either in cooperation with health education organizations or with other health authorities.
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Silakhudin. "PENENTUAN HASIL PRODUK RADIOISOTOP FLUOR-18 PADA FASILITAS SIKLOTRON DECY-13." Jurnal Penelitian Saintek 21, no. 1 (February 16, 2017): 1. http://dx.doi.org/10.21831/jps.v21i1.10555.
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Suatu perhitungan untuk menentukan hasil produk radioisotop khususnya radioisotop fluor-18 pada fasilitas siklotron proton 13 MeV telah dilakukan. Perhitungannya menggunakan rumusan thick target yield pada reaksi nuklir 18O(p,n)18F. Perhitungan ini dimaksudkan untuk memastikan bahwa rumusan dan parameter-parameter yang dipakai sudah cukup layak untuk dipakai dalam commissioning siklotron DECY-13. Hasil perhitungan telah dibandingkan dengan hasil radioisotop dari siklotron-siklotron yang ada di rumah-rumah sakit Dharmais Jakarta dan MRCCC Jakarta serta standard dari IAEA. Beda dari hasil perhitungan dengan data-data pembanding tidak lebih dari 5%, yang berarti rumus perhitungan ini cukup layak untuk digunakan dalam commissioning siklotron. Perhitungan hasil produk fluor-18 dengan menggunakan rumus tersebut adalah 1223 mCi untuk operasi siklotron 30 µA arus berkas proton selama iradiasi 40 menit
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Krug, B., M. Dietlein, W. Groth, H. Stützer, T. Psaras, A. Gossmann, K. Scheidhauer, H. Schicha, and K. Lackner. "FLUOR-18-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY (FDG-PET) IN MALIGNANT MELANOMA." Acta Radiologica 41, no. 5 (September 2000): 446–52. http://dx.doi.org/10.1034/j.1600-0455.2000.041005446.x.
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Ogawa, M., M. Hama, and K. Kuroda. "Photochromism of azobenzene in the hydrophobic interlayer spaces of dialkyldimethylammonium-fluor-tetrasilicic mica films." Clay Minerals 34, no. 2 (June 1999): 213–20. http://dx.doi.org/10.1180/000985599546127.
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AbstractPhotochemical isomerization of azobenzene intercalated in the hydrophobic, interlayer spaces of swelling fluor-tetrasilicic micas exchanged with dialkyldimethylammonium ions, with the alkyl chain length from 10 to 18, was investigated. Thin films of the organoammonium-mica-azobenzene intercalation compounds were obtained by depositing a suspension of the organoammonium-micas (prepared using a toluene/methanol solution of azobenzene) on quartz substrates. The intercalated azobenzene showed reversible photochromic reactions induced by UV and visible light irradiation. The fraction of the photochemically formed cis-isomer in the photostationary states decreased with a decrease in temperature. The observed change in the photochemical reactions is thought to reflect changes in the states of the dialkyldimethylammonium ions in the interlayer space of the swelling fluor-tetrasilicic mica.
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Heiss, W. D., K. Herholz, G. Pawlik, B. Szelies, and K. Wienhard. "PET studies of glucose metabolism of 18 fluor-deoxy-glucose in dementia." Acta Neurologica Scandinavica 79, no. 3 (March 1989): 253–54. http://dx.doi.org/10.1111/j.1600-0404.1989.tb03754.x.
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Mukhtar, A. Ummu Saadah, Budu Budu, Yusring Sanusi B, Nasruddin Andi Mappawere, and Azniah Azniah. "effect of reproductive health education with multimedia video learning on the improvement of fluor albus prevention behavior young woman pathologist." International journal of health & medical sciences 5, no. 1 (January 22, 2022): 75–79. http://dx.doi.org/10.21744/ijhms.v5n1.1841.
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Health education for adolescents is achieved properly, it requires effective and interactive media so that young women can easily understand and absorb the information provided properly. The population in this study were teenage girls in class XI Pesantren Al-Junaidiyah Biru, Pesantren Al-Ikhlas Ujung Bone and Islamic Boarding School Darussalam Pajalele Bone. Based on the determination of the number of samples, the sample in this study amounted to 18 respondents, in anticipation of dropping out of respondents from the study, the researchers set 20% so that the number of respondents was 22 respondents in each group (Using 1:1:1) so the sample in this study amounted to 66 people with purposive sampling technique. The results showed that there was an effect of reproductive health education with multimedia video learning on increasing knowledge of pathological fluor albus prevention in adolescent girls. The results showed that there was an effect of reproductive health education with multimedia video learning on improving the attitude of preventing pathological fluor albus (leucorrhoea) in adolescent girls. The results of the study indicate that there is an effect of reproductive health education with multimedia video learning on the improvement of behavior/prevention of pathological fluor albus (leucorrhoea) in adolescent girls.
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Backhaus, M., and D. Sandrock. "Nuklearmedizin." Arthritis und Rheuma 29, no. 03 (2009): 168–78. http://dx.doi.org/10.1055/s-0037-1620166.
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ZusammenfassungDie beiden wichtigsten nuklearmedizinischen Verfahren in der Rheumatologie sind die Skelettszintgrafie und die F-18-Fluor-Desoxyglucose-Positronenemissionstomografie (F-18-FDG-PET). Bei der Skelettszintigrafie wird die Anreicherung von i. v.-applizierten Technetium-99m-markierten Phosphonaten mittels einer Gamma-Kamera untersucht. Man unterscheidet Perfusionsphase (0–60 sec p. i.), Blutpoolphase (2–5 min p. i.) und Knochenstoffwechselphase (2–5 h p. i.). Die Blutpoolphase erlaubt Aussagen über die entzündliche (Weichteil-)Komponente („Arthritis“), die Knochenstoffwechselphase über länger dauernde knöcherne Prozesse („Arthrose“). Die Positronenemissionstomografie (PET) mit F-18-Fluor-Desoxyglucose (FDG) eignet sich bei einer Vielzahl von Indikationen in der Onkologie. Bei rheumatologischen Fragestellungen wird nach benignen Prozessen mit gesteigertem Glukosestoffwechsel gesucht. Dabei handelt es sich um Entzündungen in Weichteilgeweben und Gelenken (z. B. Ar-thritiden, Vaskulitiden) und insbesondere zur Diagnostik unklaren Fiebers. Im Regelfall wird eine Ganzkörpertomografie als Aufnahmeverfahren für die Fokussuche unbekannter Lokalisation oder zur Darstellung der Höhe des Glukosestoffwechsels eines oder mehrerer bekannter Herde genutzt. Verlaufsuntersuchungen unter Therapie können durchgeführt werden. Bei der Untersuchung soll der Patient nüchtern sein. Die Aufnahme erfolgt eine Stunde nach FDG-Injektion für eine Dauer von 30–60 min. Die Methode ist sensitiv und kann den Stoffwechsel von Läsionen objektivieren, ist aber nicht spezifisch (FDG reichert sich auch in malignen Veränderungen an). Die technischen Einzelheiten einschließlich Befunddokumentation beider Verfahren sind entsprechend den Leitlinien der Deutschen Gesellschaft für Nuklearmedizin dargestellt (www.nuklearmedizin.de).
Dissertations / Theses on the topic "Fluor-18"
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BONNOT-LOURS, SOPHIE. "Marquage au carbone-11 et au fluor-18 d'inhibiteurs de l'acetylcholinesterase." Paris 11, 1993. http://www.theses.fr/1993PA112361.
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Afin d'etudier l'activite acetylcholinesterasique cerebrale par tomographie d'emission de positons, nous avons entrepris la synthese et le marquage par le carbone-11 ou le fluor-18 de trois inhibiteurs de l'acetylcholinesterase. Nous avons synthetise un derive 11-c methyle de la tetrohydroaminoacridine (tha): la 11-c-methyl-tha (mtha). La tha est methylee par l'iodure de methyle apres deprotonation par l'hydrure de sodium dans le dimethylsulfoxide a 100c. L'activite specifique de la 11-c mtha, ainsi obtenue, atteint 35 gbq/micromole. Nous avons realise la synthese de la physostigmine marquee au carbone-11. Nous avons d'abord prepare l'eseroline a partir de la physostigmine. Le precurseur marque au carbone-11 est le 11-c methylisocyanate qui est obtenu par chauffage du chlorure d'acetyle marque au carbone-11 avec l'azoture de tetrabutylammonium dans le toluene. La physostigmine marquee est obtenue par reaction entre le methylisocyanate marque et l'eseroline. Plusieurs dizaines de millicuries de physostigmine marquee sont obtenues apres 60 minutes de synthese. Nous n'avons pas reussi a marquer l'heptylphysostigmine avec le fluor-18 en raison de l'instabilite de ce compose dans le milieu reactionnel
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Kienzle, Gabriele J. "Elektrochemische 18 F-Fluorierung als neuer Ansatz zur Synthese aromatischer PET-Radiopharmaka." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10236355.
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Pelletier, Rémi. "Nouvelles approches de marquage au fluor 18 et développement d'un radiotraceur pour l'imagerie TEP en oncologie." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASF035.
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La Tomographie par Émission de positons (TEP) est une technique d'imagerie médicale utilisant des atomes radioactifs émetteurs de positons. Un des principaux isotopes utilisés en TEP est le fluor 18, qui présente encore aujourd'hui des difficultés pour le marquage de certains composés compte tenu de la faible réactivité de l'anion [¹⁸F]fluorure. En particulier, l'introduction de fluor sur un noyau aromatique non activé reste un défi de radiosynthèse, limitant le développement de radiotraceurs comportant ce motif. La première partie de ces travaux est consacrée au développement de nouvelles stratégies de radiofluoration basées sur l’utilisation du bore qui possède une forte affinité pour le fluor. Deux approches ont en particulier été étudiées. La première a consisté à utiliser un atome de bore afin de diriger la fluoration aromatique et de réaliser une substitution nucléophile aromatique concertée. La seconde a été la mise en œuvre des composés borylés fluorophiles pour le transfert des [¹⁸F]fluorures aqueux produits par le cyclotron vers un solvant organique dans le but de s’affranchir des étapes de préparation et de séchage des [¹⁸F]fluorures classiquement requises. La seconde partie de ces travaux est consacrée au radiomarquage isotopique du binimetinib, un médicament pour le traitement des mélanomes BRAF mutants. Le binimetinib est un inhibiteur de l'enzyme MAPK présentant deux atomes de fluor. Au-delà du défi qu’a représenté la synthèse du [¹⁸F]binimetinib, cette molécule pourrait être un outil clef pour la stratification des populations de patients atteints de cancers mettant en jeu des mutations spécifiques entraînant la dérégulation de la voie de signalisation RAS, impliquée dans la survie et la prolifération cellulairePET is a medical imaging technique that uses positron-emitting radioactive atoms. One of the most common isotope used for PET imaging isfluorine-18, but the low reactivity of [¹⁸F]fluoride anion is still associated with labelling issues of some specific compounds. The introduction of fluorine on a non-activated aromatic ring remains a radiosynthesis challenge, limiting the development of radiotracers involving such scaffold. The first part of this work deals with the development of new strategies of radiofluorination using boron,known to have a high affinity with fluorine. Two approaches have been studied. The first one is based on the use of a boron atom to guide aromatic fluorination through a concerted nucleophilic aromatic substitution. The second one was the use of the fluorophilic borylated compounds aiming to tranfer aqueous [¹⁸F]fluorides anions produced in the cyclotron to an organic solvent to eliminate drying steps of the [¹⁸F]fluorides usually required. The second part of this work describes the radiolabeling of binimetinib, a drug prescribed for the treatment of BRAF mutant melanomas. Binimetinib is an inhibitor of the MAPK enzyme carrying two fluorine atoms. Beyond the challenge of [¹⁸F]binimetinib synthesis, this compound could be a key for the stratification of patients suffering from cancers involving specific mutations deregulating the RAS signalling pathway involved in cell survival and proliferation mechanism
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Priem, Thomas. "Développement et automatisation de la synthèse de nouveaux groupements prosthétiques pour le radiomarquage au fluor-18 de macromolécules." Rouen, 2012. http://www.theses.fr/2012ROUES050.
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La Tomographie par Emission de Positons s’est imposée comme l'une des techniques d’imagerie moléculaire les plus efficaces pour la visualisation et la compréhension de cibles et/ou phénomènes biologiques. En effet, son excellente sensibilité et les perturbations structurales minimes apportée au composés radio-marqués suite à l’introduction d’un radio-isotope, font que cette technique est potentiellement applicable à tous types de cibles. Par exemple, dans le cas de substrats sensibles, tels que des peptides ou protéines, l’introduction dans des conditions douces du radio-isotope est réalisée via l'emploi de groupements prosthétiques. L’intérêt que suscite cette technique s’est notamment traduit par la création de traceurs bi-modaux associant la TEP à d’autres techniques d’imagerie complémentaires. Au cours de cette thèse, de nouveaux groupements prosthétiques à base d’unités sultones ont été synthétisés. Les propriétés avantageuses des sultones ont pu être exploitées pour la mise au point de radio-synthèses automatisées de ces groupements prosthétiques. Ces derniers ont alors pu être appliqués au radio-marquage d’un peptide d’intérêt. Nos efforts de recherche se sont ensuite concentrés sur la synthèse de fluorophores fluorés. Nous avons notamment développé une méthode générale pour le radio-marquage, mais également l’hydrosolubilisation, de fluorophores aminés au moyen d’une réaction d’acylation efficace. Cette nouvelle stratégie a été appliquée à la préparation d’une cyanine radio-fluorée dont les propriétés spectrales en font un bon candidat pour des applications in vivoPositron Emission Tomography has emerged as a major technique of molecular imaging for the visualization and understanding of biological targets or phenomena. Indeed, thanks to its excellent sensitivity and the minor structural modifications of the radio-labeled compounds following introduction of the selected radio-isotope, there is almost no limitation in terms of targeted substrates. For example, in the case of sensitive substrates such as peptides or proteins, which are increasingly proposed as biological targets, the introduction of the radio-isotope under mild conditions is ensured by means of a prosthetic group. As a proof of its interest, PET has now been combined with other imaging techniques, such as fluorescent optical imaging or MRI, to build bimodal sensors. This growing area represents a breakthrough in the field of molecular imaging. During this PhD work, new prosthetic groups based on sultones units were synthesized. The advantageous properties of sultones have been used for the automated radio-syntheses of these prosthetic groups, which could be applied to the radio-labeling of a bio-relevant peptide. Our research interests then focused on the synthesis of fluorinated organic fluorophores, as preliminary work for the preparation of bimodal sensors. We especially designed a general way to radio-label and water-solubilize amino-based fluorophores through an efficient acylation reaction involving a previously-designed prosthetic group. This new strategy was applied for the preparation of a radio-fluorinated cyanine whose spectral properties are suitable for in vivo application
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Pauton, Mathilde. "Radiosynthèse de 3/5-[18F]-fluoropyridines à partir de précurseurs iodoniums." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC280.
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Le motif fluoropyridine est très fréquent dans les molécules d’intérêt thérapeutique et diagnostique pour l’imagerie par tomographie par émission de positons. Bien que les 3/5-[18F]fluoropyridines soient a priori plus stables in vivo que leurs analogues radiofluorés en position 2, 4 ou 6, leur radiosynthèse par voie nucléophile à partir du [18F]fluorure reste difficile et peu documentée. Dans ce contexte, les travaux ont porté sur l’étude du radiomarquage au fluor-18 de 3/5-fluoropyridines par radiofluoration de précurseurs iodoniums. Dans une première partie, la préparation d’une vingtaine de sels de iodonium possédant une structure pyridine ou pyridinium différemment substituée, a été mise au point. Une seconde partie a été dédiée à l’optimisation de la réaction de radiofluoration des sels de iodoniums. Cette étude a conduit à la mise en évidence du rôle important du TEMPO et de la base K2CO3 dans cette réaction. Enfin, la dernière partie a été consacrée à la radiosynthèse de 3/5-[18F]fluoropyridines portant des groupements carboxamides ou aminés par une approche multi-étape. L’ensemble des résultats ont montré que la radiofluoration de triflates de iodonium en présence de TEMPO était une méthode efficace, générale et robuste de radiosynthèse de 3/5-[18F]fluoropyridines. Cette méthode a été transposée avec succès sur deux automates de synthèseThe fluoropyridinyl moieties have become of increasing importance in the development of drug candidates as well as of radiotracers for positron emission tomography (PET) imaging after radiolabeling with fluorine-18. Although 3/5-[18F]fluoropyridines are more stable in vivo than their 2,4 or 6 radiofluorinated analogues, their radiosynthesis by nucleophilic pathway from cyclotron produced [18F]fluoride remains difficult and poorly documented. In this context, the work focused on the development of a robust and general route to 3/5-[18F]fluoropyridines based on the radiofluorination of iodonium precursors. In a first part, the preparation of about twenty iodonium salts containing a pyridine or pyridinium scaffold, has been developed. A second part was devoted to the optimization of the radiofluorination reaction of iodonium salts. This study highlighted the important role of TEMPO and K2CO3 in this reaction. Finally, the last part was dedicated to the radiosynthesis of 3/5-[18F]fluoropyridines bearing carboxamide or amine groups according to a multistep approach. All the results showed that radiofluorination of iodonium triflates in the presence of TEMPO was an efficient, general and robust method for the radiosynthesis of 3/5-[18F]fluoropyridines. This method was also successfully transposed on two automated systems
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Pretze, Marc. "Entwicklung von Radiotracern für die radiopharmakologische Charakterisierung von Eph-Rezeptoren." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-148062.
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Eph receptors are known to be overexpressed in various types of cancer and are therefore promising targets for tumor cell imaging by positron emission tomography (PET). In this regard, imaging could facilitate the early detection of Eph-overexpressing tumors, monitoring responses to therapy directed toward Eph, and thus improvement in patient outcomes.
This work report the synthesis and evaluation of several fluorine-18-labeled peptides containing the SNEW and SWLAY amino acid motif, with high affinity for the EphA2 and B2 receptor, for their potential as radiotracers in the non-invasive imaging of cancer using PET. For the purposes of radiofluorination, EphA2- and EphB2-antagonistic peptides were varied at the C-terminus by the introduction of L-cysteine, and further by alkyne- or azide-modified amino acids. In addition, two novel bifunctional and bioorthogonal labeling building blocks [18F]AFP and [18F]BFP were applied, and their capacity to introduce fluorine-18 was compared with that of the established building block [18F]FBAM.
Copper-assisted Huisgen 1,3-dipolar cycloaddition, which belongs to the set of bioorthogonal click chemistry reactions, was used to introduce both novel building blocks into azide- or alkyne-modified peptides under mild conditions. Finally, the depletion of copper immediately after radiolabeling is a highly important step of this novel methodology.
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Vala, Christine. "Synthèse de groupements prosthétiques glucidiques : vers de nouveaux traceurs peptidiques pour l'imagerie par tomographie par émission de positons (TEP)." Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10031/document.
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L’utilisation de peptides ou de protéines radiomarquées au fluor-18, comme radiotraceurs pour l’imagerie par Tomographie par Emission de Positons (TEP) est en plein essor. C’est ainsi que l’objectif de notre travail a été de concevoir et de synthétiser de nouveaux groupements prosthétiques de nature glucidique, analogues du 2-Fluoro-2-[18F]désoxy-D-glucose ([18F]FDG). La particularité de ces derniers, est qu’ils sont porteurs de motifs azides afin de les lier de façon simple et efficace à des biomolécules fonctionnalisées par des groupements alcynes via la réaction de Huisgen ou réaction de « click chemistry ». Le premier objectif de ce travail a été d’étudier la position idéale d’introduction du motif azide sur le FDG, soit sur la position C-1, soit sur la position C-6. Deux stratégies de synthèse différentes ont été développées pour aboutir à deux générations de précurseurs de marquage et à leurs références froides, permettant ainsi d’évaluer l’étape d’incorporation du fluor-18. Le second objectif a été d’introduire un groupement propargyle sur la phénylalanine, la cystéine et le glutathion afin de réaliser le couplage par click chemistry avec le meilleur groupement prosthétique obtenuThe use of peptides or proteins labeled with fluorine-18, as agents for Positron Emission Tomography (PET) is a rapidly growing field. Thus, the objective of our work was to create and to synthesize new glycosyl prosthetic groups, which are analogs of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). The particularity of these compounds is their azide moiety which enables a simple and efficient ligation with alkynylated amino acids via a Huisgen type reaction or “click Chemistry”. The first goal was to study the ideal position for the introduction of the azide moiety on the sugar, either at the C-1 or C-6 position. In order to evaluate the incorporation of fluorine-18, two different strategies were developed to obtain two generations of labeled precursors and cold references. The second objective was to synthesize alkynylated phenylalanine, cysteine and gluthation derivatives to test the “click Chemistry” ligation method with the best prosthetic group
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Ladzik, Simone [Verfasser]. "Untersuchungen zur Radionuklidbereitstellung von Fluor-18 für die Synthese von 18F-markierten PET-Tracern mit Hilfe von automatisierter fluider Synthesetechnik / Simone Ladzik." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1204479739/34.
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Nordeman, Patrik. "Development of Palladium-Promoted 11C/12C-Carbonylations and Radiosynthesis of Amyloid PET Ligands." Doctoral thesis, Uppsala universitet, Plattformen för preklinisk PET, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-213863.
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In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new method for the safe, efficient use of a solid carbon monoxide source in the synthesis of primary and secondary benzamides. In total, 35 benzamides were synthesized from aryl iodides (20 examples, 69-97% yield) and aryl bromides (15 examples, 32-93% yield). Reduction-prone groups were used successfully in the reactions. In paper II, the same protocol was adopted for the palladium(0)-catalyzed synthesis of N-cyanobenzamides from aryl iodides/bromides, carbon monoxide and cyanamide. In total, 22 N-cyanobenzamides were synthesized (42-88% yield). The radiosynthesis of [11C]N-cyanobenzamides is discussed in paper III. In total, 22 compounds were synthesized from various aryl halides in 28-79% decay corrected radiochemical yield. The protocol was then applied to the radiosynthesis of [11C]N-cyanobenzamide analogs of flufenamic acid and dazoxibene. In the second part of this thesis, compounds of interest in relation to amyloid diseases are discussed. Paper IV describes the solid-phase synthesis of BACE-1 enzyme inhibitors containing secondary and tertiary hydroxyl as the transition state isostere. In total, 22 inhibitors were synthesized. The most potent compound (IC50= 0.19 µM) was co-crystallized at the active site of the enzyme to reveal a new binding mode. In paper V, the evaluation of a potent BACE-1 inhibitor as a potential radiotracer for use in PET is described. The radiolabeled [11C]BSI-IV was obtained in 29±12% decay corrected radiochemical yield by a three-component palladium(0)-mediated aminocarbonylation. Its properties as a potential PET tracer were investigated in vitro by autoradiography and in vivo in rats using small animal PET-CT. A new class of amyloid-binding PET ligands is described in paper VI. Three polythiophenes were labeled with carbon-11 or fluorine-18 (26-43% decay-corrected radiochemical yield). The in vitro studies showed that these ligands bind specifically to amyloid deposits. In vivo PET showed low uptake in the organs of interest in healthy rats and a monkey. These results suggest the labeled thiophenes derivatives could be useful as PET tracers for the study of amyloid diseases.
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Da, Costa Emilie. "Synthèse d'huprines marquées au fluor-18 pour l'imagerie TEP de l'acétylcholinestérase et le suivi de la maladie d'Alzheimer." Chimie organique, bioorganique : réactivité et analyse (Mont-Saint-Aignan, Seine-Maritime ; 1996-....), 2013. http://www.theses.fr/2013ROUES045.
Full textBooks on the topic "Fluor-18"
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Kälicke, Thomas. Multizentrische Auswertung der Fluor-18-2-Deoxy-D-Glukose-Positronen-Emmissions-Tomographie bei differenzierten Schilddrüsentumoren. 1999.
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Entwicklung und Optimierung von Verfahren zur Radiofluorierung aromatischer Verbindungen mit Fluor-18 hoher spezifischer Aktivität. Jülich: Zentralbibliothek der Kernforschungsanlage, 1987.
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Wendel, Jürgen. Markierung von Radiopharmaka für die nuklearmedizinische Diagnostik mit Fluor-18 und Iod-123 durch heterogene Katalyse. 1994.
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Kiel, Universität, ed. Die klinische Wertigkeit der Fluor-18-Desoxyglucose-Positronenemissionstomographie in der Therapieplanung bei Patienten mit Nicht-kleinzelligem Bronchialkarzinom. 2004.
Find full textBook chapters on the topic "Fluor-18"
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Klever, P., R. Bares, J. Faß, U. Büll, and V. Schumpelick. "Zur Wertigkeit der Positronen-Emissions-Tomographie (PET) mit 18-Fluor Desoxyglucose (18-FDG) zur Differentialdiagnose von Pankreascarcinom/Pankreatitis: Erste klinische Erfahrungen." In Chirurgisches Forum ’92 für experimentelle und klinische Forschung, 11–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77389-1_3.
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"Ganzkörper Fluor-18-Fluordeoxyglukose (FDG)-PET zum Nachweis okkulter metastasierter Schilddrüsenkarzinome." In Schilddrüse 1995, 424–33. De Gruyter, 1996. http://dx.doi.org/10.1515/9783110822281-052.
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Taber, Douglass F. "Organic Functional Group Interconversion." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0003.
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Alois Fürstner of the Max-Planck-Institut Mülheim devised (Angew. Chem. Int. Ed. 2013, 52, 14050) a Ru catalyst for the trans- selective hydroboration of an alkyne 1 to 2. Qingbin Liu of Hebei Normal University and Chanjuan Xi of Tsinghua University coupled (Org. Lett. 2013, 15, 5174) the alkenyl zirconocene derived from 3 with an acyl azide to give the amide 4. Chulbom Lee of Seoul National University used (Angew. Chem. Int. Ed. 2013, 52, 10023) a Rh catalyst to convert a terminal alkyne 5 to the ester 6. Laura L. Anderson of the University of Illinois, Chicago devised (Org. Lett. 2013, 15, 4830) a protocol for the conversion of a terminal alkyne 7 to the α-amino aldehyde 9. Dewen Dong of the Changchun Institute of Applied Chemistry developed (J. Org. Chem. 2013, 78, 11956) conditions for the monohydrolysis of a bis nitrile 10 to the monoamide 11. Aiwen Lei of Wuhan University optimized (Chem. Commun. 2013, 49, 7923) a Ni catalyst for the conversion of the alkene 12 to the enamide 13. Kazushi Mashima of Osaka University optimized (Adv. Synth. Catal. 2013, 355, 3391) a boronic ester catalyst for the conversion of an amide 14 to the ester 15. Jean- François Paquin of the Université Laval prepared (Eur. J. Org. Chem. 2013, 4325) the amide 17 by coupling an amine with the activated intermediate from reaction of an acid 16 with Xtal- Fluor E. Steven Fletcher of the University of Maryland School of Pharmacy designed (Tetrahedron Lett. 2013, 54, 4624) the azodicarbonyl dimorpholide 18 as a reagent for the Mitsunobu coupling of 19 with 20. The reduced form of 18 was readily separated by extraction into water and reoxidized. Jens Deutsch of the Universität Rostock found (Chem. Eur. J. 2013, 19, 17702) simple ligands for the Ru-mediated borrowed hydrogen conversion of an alcohol 22 to the amine 23. Ronald T. Raines of the University of Wisconsin devised (J. Am. Chem. Soc. 2013, 135, 14936) a phosphinoester for the efficient conversion in water of an azide 24 to the diazo 25.
Conference papers on the topic "Fluor-18"
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Borchardt, D., A. Lesikov, T. Lindner, A. Altmann, FL Giesel, C. Kratochwil, C. Kleist, et al. "Fluor-18-markierte FAPI-Tracer für die PET-Bildgebung." In NuklearMedizin 2020. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1708428.
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Willmann, M., BD Zlatopolskiy, L. Donnerstag, EA Urusova, H. Endepols, and B. Neumaier. "3-Aza-6—F-18-fluor-isatosäureanhydride (F-18-AFIAs) - neue leicht zugängliche prosthetische Gruppen für die indirekte Radiomarkierung." In NuklearMedizin 2021 – digital. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1726694.
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Schneider, Jerry, Jeffrey Wagner, and Judy Connell. "Restoring Public Trust While Tearing Down Site in Rural Ohio." In The 11th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2007. http://dx.doi.org/10.1115/icem2007-7319.
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In the mid-1980s, the impact of three decades of uranium processing near rural Fernald, Ohio, 18 miles northwest of Cincinnati, became the centre of national public controversy. When a series of incidents at the uranium foundry brought to light the years of contamination to the environment and surrounding farmland communities, local citizens’ groups united and demanded a role in determining the plans for cleaning up the site. One citizens’ group, Fernald Residents for Environmental Safety and Health (FRESH), formed in 1984 following reports that nearly 300 pounds of enriched uranium oxide had been released from a dust-collector system, and three off-property wells south of the site were contaminated with uranium. For 22 years, FRESH monitored activities at Fernald and participated in the decision-making process with management and regulators. The job of FRESH ended on 19 January this year when the U.S. Secretary of Energy Samuel Bodman and U.S. Environmental Protection Agency Administrator Stephen Johnson — flanked by local, state, and national elected officials, and citizen-led environmental watchdog groups including FRESH — officially declared the Fernald Site clean of all nuclear contamination and open to public access. It marked the end of a remarkable turnaround in public confidence and trust that had attracted critical reports from around the world: the Cincinnati Enquirer; U.S. national news programs 60 Minutes, 20/20, Nightline, and 48 Hours; worldwide media outlets from the British Broadcasting Company and Canadian Broadcasting Company; Japanese newspapers; and German reporters. When personnel from Fluor arrived in 1992, the management team thought it understood the issues and concerns of each stakeholder group, and was determined to implement the decommissioning scope of work aggressively, confident that stakeholders would agree with its plans. This approach resulted in strained relationships with opinion leaders during the early months of Fluor’s contract. To forge better relationships, the U.S. Department of Energy (DOE) who owns the site, and Fluor embarked on three new strategies based on engaging citizens and interested stakeholder groups in the decision-making process. The first strategy was opening communication channels with site leadership, technical staff, and regulators. This strategy combined a strong public-information program with two-way communications between management and the community, soliciting and encouraging stakeholder participation early in the decision-making process. Fluor’s public-participation strategy exceeded the “check-the-box” approach common within the nuclear-weapons complex, and set a national standard that stands alone today. The second stakeholder-engagement strategy sprang from mending fences with the regulators and the community. The approach for dispositioning low-level waste was a 25-year plan to ship it off the site. Working with stakeholders, DOE and Fluor were able to convince the community to accept a plan to safely store waste permanently on site, which would save 15 years of cleanup and millions of dollars in cost. The third strategy addressed the potentially long delays in finalizing remedial action plans due to formal public comment periods and State and Federal regulatory approvals. Working closely with the U.S. and Ohio Environmental Protection Agencies (EPA) and other stakeholders, DOE and Fluor were able to secure approvals of five Records of Decision on time – a first for the DOE complex. Developing open and honest relationships with union leaders, the workforce, regulators and community groups played a major role in DOE and Fluor cleaning up and closing the site. Using lessons learned at Fernald, DOE was able to resolve challenges at other sites, including worker transition, labour disputes, and damaged relationships with regulators and the community. It took significant time early in the project to convince the workforce that their future lay in cleanup, not in holding out hope for production to resume. It took more time to repair relationships with Ohio regulators and the local community. Developing these relationships over the years required constant, open communications between site decision makers and stakeholders to identify issues and to overcome potential barriers. Fluor’s open public-participation strategy resulted in stakeholder consensus of five remedial-action plans that directed Fernald cleanup. This strategy included establishing a public-participation program that emphasized a shared-decision making process and abandoned the government’s traditional, non-participatory “Decide, Announce, Defend” approach. Fernald’s program became a model within the DOE complex for effective public participation. Fluor led the formation of the first DOE site-specific advisory board dedicated to remediation and closure. The board was successful at building consensus on critical issues affecting long-term site remediation, such as cleanup levels, waste disposal and final land use. Fluor created innovative public outreach tools, such as “Cleanopoly,” based on the Monopoly game, to help illustrate complex concepts, including risk levels, remediation techniques, and associated costs. These innovative tools helped DOE and Fluor gain stakeholder consensus on all cleanup plans. To commemorate the outstanding commitment of Fernald stakeholders to this massive environmental-restoration project, Fluor donated $20,000 to build the Weapons to Wetlands Grove overlooking the former 136-acre production area. The grove contains 24 trees, each dedicated to “[a] leader(s) behind the Fernald cleanup.” Over the years, Fluor, through the Fluor Foundation, also invested in educational and humanitarian projects, contributing nearly $2 million to communities in southwestern Ohio, Kentucky and Indiana. Further, to help offset the economic impact of the site’s closing to the community, DOE and Fluor promoted economic development in the region by donating excess equipment and property to local schools and townships. This paper discusses the details of the public-involvement program — from inception through maturity — and presents some lessons learned that can be applied to other similar projects.
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Vogel, J., T. Küstner, A. Forschner, P. Martus, C. Garbe, C. Pfannenberg, K. Nikolaou, C. la Fougère, and F. Seith. "Identifikation von prädiktiven Faktoren in der multiparametrische Ganzkörper Fluor-18-FDG-PET/MR-Bildgebung bei Patienten mit metastasiertem Melanom unter CIT." In NuklearMedizin 2020. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1708178.
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