Academic literature on the topic 'Fluorescence contrast agents'

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Journal articles on the topic "Fluorescence contrast agents"

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Celia Henry Arnaud. "Contrast agents improve fluorescence-guided surgery." C&EN Global Enterprise 98, no. 38 (2020): 11. http://dx.doi.org/10.1021/cen-09838-scicon5.

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Zhang, Qimei, Stephen P. Morgan, Paul O’Shea, and Melissa L. Mather. "Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents." PLOS ONE 11, no. 7 (2016): e0159742. http://dx.doi.org/10.1371/journal.pone.0159742.

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Laramie, Matt, Mary Smith, Fahad Marmarchi, Lacey McNally, and Maged Henary. "Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging." Molecules 23, no. 11 (2018): 2766. http://dx.doi.org/10.3390/molecules23112766.

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Almost every variety of medical imaging technique relies heavily on exogenous contrast agents to generate high-resolution images of biological structures. Organic small molecule contrast agents, in particular, are well suited for biomedical imaging applications due to their favorable biocompatibility and amenability to structural modification. PET/SPECT, MRI, and fluorescence imaging all have a large host of small molecule contrast agents developed for them, and there exists an academic understanding of how these compounds can be developed. Optoacoustic imaging is a relatively newer imaging te
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Sevick-Muraca, Eva M., Jessica P. Houston, and Michael Gurfinkel. "Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents." Current Opinion in Chemical Biology 6, no. 5 (2002): 642–50. http://dx.doi.org/10.1016/s1367-5931(02)00356-3.

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NOTHDURFT, R., P. SARDER, S. BLOCH, J. CULVER, and S. ACHILEFU. "Fluorescence lifetime imaging microscopy using near-infrared contrast agents." Journal of Microscopy 247, no. 2 (2012): 202–7. http://dx.doi.org/10.1111/j.1365-2818.2012.03634.x.

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CHEN, CHAO-WEI, TIFFANY R. BLACKWELL, RENEE NAPHAS, et al. "DEVELOPMENT OF NEEDLE-BASED MICROENDOSCOPY FOR FLUORESCENCE MOLECULAR IMAGING OF BREAST TUMOR MODELS." Journal of Innovative Optical Health Sciences 02, no. 04 (2009): 343–52. http://dx.doi.org/10.1142/s1793545809000747.

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Fluorescence molecular imaging enables the visualization of basic molecular processes such as gene expression, enzyme activity, and disease-specific molecular interactions in vivo using targeted contrast agents, and therefore, is being developed for early detection and in situ characterization of breast cancers. Recent advances in developing near-infrared fluorescent imaging contrast agents have enabled the specific labeling of human breast cancer cells in mouse model systems. In synergy with contrast agent development, this paper describes a needle-based fluorescence molecular imaging device
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Saladino, Giovanni M., Nuzhet I. Kilic, Bertha Brodin, et al. "Carbon Quantum Dots Conjugated Rhodium Nanoparticles as Hybrid Multimodal Contrast Agents." Nanomaterials 11, no. 9 (2021): 2165. http://dx.doi.org/10.3390/nano11092165.

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Nanoparticle (NP)-based contrast agents enabling different imaging modalities are sought for non-invasive bio-diagnostics. A hybrid material, combining optical and X-ray fluorescence is presented as a bioimaging contrast agent. Core NPs based on metallic rhodium (Rh) have been demonstrated to be potential X-ray Fluorescence Computed Tomography (XFCT) contrast agents. Microwave-assisted hydrothermal method is used for NP synthesis, yielding large-scale NPs within a significantly short reaction time. Rh NP synthesis is performed by using a custom designed sugar ligand (LODAN), constituting a str
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Gurfinkel, Michael, Shi Ke, Xiaoxia Wen, Chun Li, and Eva M. Sevick-Muraca. "Near-Infrared Fluorescence Optical Imaging and Tomography." Disease Markers 19, no. 2-3 (2004): 107–21. http://dx.doi.org/10.1155/2004/474818.

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The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises selective and specific molecular targeting of diseased tissues. As an example of one area of the field, recent work focusing on pharmacokinetic analysis of fluorophores targeting the epidermal growth fact
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DACOSTA, RALPH S., YING TANG, TUULA KALLIOMAKI, et al. "IN VIVO NEAR-INFRARED FLUORESCENCE IMAGING OF HUMAN COLON ADENOCARCINOMA BY SPECIFIC IMMUNOTARGETING OF A TUMOR-ASSOCIATED MUCIN." Journal of Innovative Optical Health Sciences 02, no. 04 (2009): 407–22. http://dx.doi.org/10.1142/s1793545809000759.

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Background and Aims: Accurate endoscopic detection of premalignant lesions and early cancers in the colon is essential for cure, since prognosis is closely related to lesion size and stage. Although it has great clinical potential, autofluorescence endoscopy has limited tumor-to-normal tissue image contrast for detecting small preneoplastic lesions. We have developed a molecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate which targets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescence-based endoscopy of colon cancer. Methods
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Chu, Chia-Hui, Shih-Hsun Cheng, Nai-Tzu Chen, Wei-Neng Liao, and Leu-Wei Lo. "Microwave-Synthesized Platinum-Embedded Mesoporous Silica Nanoparticles as Dual-Modality Contrast Agents: Computed Tomography and Optical Imaging." International Journal of Molecular Sciences 20, no. 7 (2019): 1560. http://dx.doi.org/10.3390/ijms20071560.

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Nanoparticle-based imaging contrast agents have drawn tremendous attention especially in multi-modality imaging. In this study, we developed mesoporous silica nanoparticles (MSNs) for use as dual-modality contrast agents for computed tomography (CT) and near-infrared (NIR) optical imaging (OI). A microwave synthesis for preparing naked platinum nanoparticles (nPtNPs) on MSNs (MSNs-Pt) was developed and characterized with physicochemical analysis and imaging systems. The high density of nPtNPs on the surface of the MSNs could greatly enhance the CT contrast. Inductively coupled plasma mass spec
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Dissertations / Theses on the topic "Fluorescence contrast agents"

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Leung, Ho-hon Arthur, and 梁浩瀚. "Lanthanide complexes for magnetic resonance imaging (MRI) contrast agents and fluorescence probes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47752774.

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In this work, novel Gd(III) complexes endowed with non-steroidal anti-inflammatory drugs (NSAIDs) were synthesised and their targeting properties towards sites of inflammation were studied in U87 xenograft and rheumatoid arthritis animal models. The Tb(III) analogues were also synthesised and their photophysical properties were studied. Six new Gd(III) DO3A-amide complexes bearing different linkers, ethylenediamine (GdL1), hexamethylenediamine (GdL2), 2,2’-oxydiethylamine (GdL3), 4,7,10-trioxa-1,13-tridecanediamine (GdL4), trans-1,4-cyclohexanediamine (GdL5), and 1,4-phenylenediamine (GdL6)
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Gurfinkel, Mikhail. "Cancer diagnostics using dynamic near-infrared optical imaging and fluorescent contrast agents." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3162.

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A new optical imaging modality has been developed for small animal in vivo imaging of near-infrared fluorescence resulting from fluorescent contrast agents specifically targeted to molecular markers of cancer. The imaging system is comprised of an intensified charge-coupled device (ICCD) for the detection of ultra-low levels of re-emitted fluorescence following the delivery of an expanded beam of excitation light. The design of the ICCD detection system allows for both continuous wave (CW) and frequency-domain modes of operation. Since the accurate acquisition of frequency-domain photon migrat
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Hubbard, Kendra Lynette. "Purification and Structural Characterization of a Novel Class of Protein- Based Magnetic Resonance Imaging Contrast Agents." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/33.

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More than one-third of all Magnetic Resonance Imaging (MRI) scans employ image-enhancing contrast agents to increase the differential signal intensity between diseased and normal tissue. Because current clinical contrast agents exhibit low relaxivity (mM-1 s-1), low dose efficiency, and rapid secretion, we have designed a group of protein-based MRI contrast agents with multiple gadolinium binding sites. In this study, the developed purification method for Class ProCA-3 agents allows for a quick and cost-effective way to abstract up to 109 mg of pure, soluble protein from a 1L E. Coli cell pell
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Godavarty, Anuradha. "Fluorescence enhanced optical tomography on breast phantoms with measurements using a gain modulated intensified CCD imaging system." Texas A&M University, 2003. http://hdl.handle.net/1969.1/2184.

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Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in-vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. However, prior to the administration of unproven contrast agents, the benefits of fluorescence-enhanced optical imaging must be assessed in feasibility phantom studies. A novel intensified charge-coupled device (ICCD) imaging system has been developed to perform 3-D fluorescence tomographic imaging in the frequency-domain using near-infrared contrast agents. This study is unique since it (i) employs
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Kilic, Nüzhet Inci. "Graphene Quantum Dots as Fluorescent and Passivation Agents for Multimodal Bioimaging." Thesis, KTH, Tillämpad fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298302.

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Zero-dimensional graphene (carbon) quantum dots have been drawing attention in bio-related applications since their discovery, especially for their optical properties, chemical stability, and easily modifiable surface.  This thesis focuses on the green synthesis of nitrogen-doped graphene quantum dots (GQDs) for dual-mode bioimaging with X-ray fluorescence (XRF) and optical fluorescence. Both conventional and microwave- (MW-)assisted solvothermal methods were followed to investigate the precursors’ effect on the synthesized GQDs. The MW-assisted method permitted the synthesis of uniform GQDs w
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Larivière, Mélusine. "Nanoparticles functionalized with human antibodies for multimodal molecular imaging of atherosclerosis." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0389/document.

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L'athérosclérose, à l’origine de la plupart des maladies cardiovasculaires telles que l'infarctus du myocarde ou l'AVC, est la principale cause de décès dans le monde. Les cliniciens ont donc besoin de techniques d'imagerie fiables pour identifier les patients «vulnérables» porteur d’athérome à haut risque d'occlusion thrombotique. Cette pathologie est une maladie inflammatoire qui implique beaucoup d'acteurs cellulaires et moléculaires, parmi lesquels les cellules endothéliales et immunitaires, les lipoprotéines, les cellules apoptotiques et les plaquettes. L'imagerie moléculaire visant à dét
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Pinho, Sonia Luzia Claro. "Nanoparticules multifonctionelles pour la résonance magnétique et l'imagerie fluorescente." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2011. http://tel.archives-ouvertes.fr/tel-00661206.

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Cette thèse décrit une stratégie de synthèse de nouvelles générations des nanoparticules (NPs) pour applications biomédicales, visant à une amélioration de leurs performances pour l'imagerie, le diagnostic thérapeutique. Ces NPs présentent plusieurs fonctionnalités leur permettant de réaliser des tâches multiples. Deux types de sondes bimodales ont été développés et étudiés afin d'évaluer leur potentiel comme agents (1) de contraste en IRM et (2) luminescents. Ces objetscombinent les propriétés des complexes de lanthanide (Ln3+) et celles des NPs de silice ou de type coeur-écorce Fe2O3SiO2 pou
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Udovich, Joshua Anthony. "CONFOCAL MICROENDOSCOPY: CHARACTERIZATION OF IMAGING BUNDLES, FLUORESCENT CONTRAST AGENTS, AND EARLY CLINICAL RESULTS." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195003.

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Ovarian cancer is the fifth leading cause of cancer related deaths among women. Early detection improves the chances of survival following diagnosis, and new imaging modalities have the potential to reduce deaths due to this disease. The confocal microendoscope (CME) is a non-destructive in-vivo imaging device for visualization of the ovaries that operates in real-time. Two components of the CME system are evaluated in this paper, and initial results from an ongoing clinical trial are presented.Fiber-optic imaging bundles are used in the CME imaging catheter to relay images over distances of u
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Silva, Uéslen Rocha. "Nanopartículas multifuncionais de fluoreto de lantânio dopadas com Nd3+ como agentes de contrastes e terapêuticos." Universidade Federal de Alagoas, 2014. http://www.repositorio.ufal.br/handle/riufal/1702.

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In this work, we investigated the possible applications of Nd3+ ions doped lanthanium trifluoride (LaF3) nanocrystals as infrared constrast agents in the first and second biological windows of the electromagnetic spectrum, which extend from 700 to 1400 nm. For this, we use the three emissions of Nd3+ ions centered around 900, 1060, and 1330 nm, corresponding to transitions generated from the metastable state 4F3/2. In comparison with other fluorescent nanoparticles (NPs) used as biolables agents, such as semiconductor quantum dots and multiphotonic luminescent NPs, the Nd3+ doped LaF3 NPs pres
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Martina, Marie Sophie. "Conception de magnétoliposomes furtifs pour le diagnostic et la thérapie anti-cancéreuse." Paris 11, 2006. http://www.theses.fr/2006PA114831.

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Un nouveau système hybride résultant de l'encapsulation de nanoparticules d'oxyde de fer superparamagnétiques dans des vésicules phospholipidiques stabilisées stériquement par des chaînes de poly(éthylène glycol) (PEG) a été mis au point et caractérisé. Ces magnétoliposomes, stables et biocompatibles sont d'excellents agents de contraste pour l'imagerie par résonance magnétique (IRM) qui, par application d'un gradient de champ magnétique externe, peuvent être guidés in vivo dans le tissu tumoral ou un hémisphère cérébral. In vitro, la présence de chaînes de PEG réduit fortement l'association m
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Book chapters on the topic "Fluorescence contrast agents"

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Nguyen, Mai-Dung, and Kyung A. Kang. "MMP-14 Triggered Fluorescence Contrast Agent." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-38810-6_54.

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Kang, Kyung A., Jianting Wang, Martin G. O’Toole, et al. "Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles." In Oxygen Transport to Tissue XXXIII. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-1566-4_42.

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Kang, Kyung Aih, and Mai-Dung Nguyen. "Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55231-6_52.

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Chang, Walter H., Cheng-An J. Lin, Ching-Yi Chang, and Wen-Fu Lai. "Synthesis of Gadolinium-doped Fluorescent Au/Ag Nanoclusters as Bimodal MRI Contrast Agents." In IFMBE Proceedings. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-00846-2_210.

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Wang, Jianting, Martin O’Toole, Archna Massey, et al. "Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle." In Oxygen Transport to Tissue XXXII. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-7756-4_21.

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Chen, Jingqin, Chengbo Liu, and Liang Song. "Indocyanine Green Loaded, PEGylated, Reduced Graphene Oxide as a Highly Efficient Passive Targeting Contrast Agent for Photoacoustic/Fluorescence Dual-Modality Tumor Imaging." In International Conference on Biomedical and Health Informatics. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-4505-9_22.

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Sevick-Muraca, Eva M., Anuradha Godavarty, Jessica P. Houston, Alan B. Thompson, and Ranadhir Roy. "Near-Infrared Imaging with Fluorescent Contrast Agents." In Handbook of Biomedical Fluorescence. CRC Press, 2003. http://dx.doi.org/10.1201/9780203912096-14.

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Sevick-Muraca, Eva, Anuradha Godavarty, Jessica Houston, Alan Thompson, and Ranadhir Roy. "Near-infrared Imaging With Fluorescent Contrast Agents." In Handbook of Biomedical Fluorescence. CRC Press, 2003. http://dx.doi.org/10.1201/9780203912096.ch14.

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Gedda, Gangaraju, Arun Bhupathi, and V. L. N. Balaji Gupta Tiruveedhi. "Naturally Derived Carbon Dots as Bioimaging Agents." In BioMechanics and Functional Tissue Engineering [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96912.

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The recent advances in nanoscience and technology have opened new avenues for carbon-based nanomaterials. Especially, Carbon dots (CDs) have gained significant attention due to their simple, economic and rapid green synthesis. These materials exhibit excellent water solubility, fluorescence emission, high fluorescence quantum yield, Ultraviolet (UV) to Infrared (IR) range absorbance and high bio-compatibility. Therefore, these materials are widely used for various biological applications including bio-imaging. With the integration and doping of surface passive agents and elements, respectively influenced the enhancement of fluorescence property of CDs. Also, the conjugation of receptor-based targeting ligands leads to targeted bioimaging. CDs in combination with other imaging contrast agents lead to the development of novel contrast agents for bimodal imaging and multimodal imaging techniques. The combination of diagnostic CDs with therapeutic agents resulted in the formation of theragnostic CDs for image guided therapies. In this chapter, a comprehensive view on the top-down and bottom–up green synthesis methods for naturally derived CDs discussed. Further, unique physical, chemical, optical and biological properties of CDs described. Finally, fluorescence based bimodal and multimodal imaging techniques also described.
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Nguyen, Van Phuc, Wei Qian, Xueding Wang, and Yannis M. Paulus. "Functionalized contrast agents for multimodality photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy molecular retinal imaging." In Methods in Enzymology. Elsevier, 2021. http://dx.doi.org/10.1016/bs.mie.2021.06.038.

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Conference papers on the topic "Fluorescence contrast agents"

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Chen, Yu, Qian Liu, Ping Huang, et al. "Assessment of tumor angiogenesis using fluorescence contrast agents." In Third International Conference on Photonics and Imaging in Biology and Medicine, edited by Qingming Luo, Valery V. Tuchin, Min Gu, and Lihong V. Wang. SPIE, 2003. http://dx.doi.org/10.1117/12.546210.

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Chen, Yu, Gang Zheng, Zhihong Zhang, et al. "Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents." In SPIE Proceedings, edited by Valery V. Tuchin. SPIE, 2004. http://dx.doi.org/10.1117/12.578379.

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Zhang, Qimei, Matthew D. Moles, Melissa L. Mather, and Stephen P. Morgan. "Ultrasound modulated fluorescence emission from Pyrene-labelled liposome contrast agents." In Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), edited by Qingming Luo, Lihong V. Wang, and Valery V. Tuchin. SPIE, 2014. http://dx.doi.org/10.1117/12.2069138.

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Li, X. D., B. Chance, and A. G. Yodh. "Detecting Optical Heterogeneities in Turbid Media Using Contrast Agents: Fluorescence vs Absorption." In Biomedical Optical Spectroscopy and Diagnostics. OSA, 1998. http://dx.doi.org/10.1364/bosd.1998.bmb1.

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Gaitan, Brandon, Rosalie Elespuru, Ellen Oskoui, et al. "Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production." In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, edited by Samuel Achilefu and Ramesh Raghavachari. SPIE, 2021. http://dx.doi.org/10.1117/12.2579521.

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Gray, Dan, Evgenia Kim, Victoria E. Cotero, et al. "Fluorescence image guided surgical instruments and contrast agents for intraoperative visualization of nerves." In CLEO: Applications and Technology. OSA, 2012. http://dx.doi.org/10.1364/cleo_at.2012.ath4c.2.

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Pu, Y., W. B. Wang, B. B. Das, S. Achilefu, and R. R. Alfano. "Time-resolved fluorescence polarization of cancer receptor-targeted contrast agents in prostate tissues." In Conference on Lasers and Electro-Optics. OSA, 2009. http://dx.doi.org/10.1364/cleo.2009.jthe64.

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Gravier, J., T. Delmas, A. C. Couffin, et al. "Lipid nanoparticles (LNP): a new technology for fluorescence contrast agents with improved properties." In BiOS, edited by Samuel Achilefu and Ramesh Raghavachari. SPIE, 2010. http://dx.doi.org/10.1117/12.840930.

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Huang, Ping, Xavier Intes, Shoko Nioka, and Britton Chance. "Pharmacokinetics model to assess the extravasation of tumor tissue by using fluorescence contrast agents." In Biomedical Topical Meeting. OSA, 2004. http://dx.doi.org/10.1364/bio.2004.thf9.

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Yu, Shuai, Ming-Yuan Wei, Bingbing Cheng, Kytai T. Nguyen, Yi Hong, and Baohong Yuan. "Stability study of Ultrasound-Switchable Fluorescence contrast agents: ICG-encapsulated poly (N-isopropylacrylamide) nanoparticles." In Bio-Optics: Design and Application. OSA, 2015. http://dx.doi.org/10.1364/boda.2015.jt3a.50.

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