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Journal articles on the topic 'Fluorescence contrast agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Celia Henry Arnaud. "Contrast agents improve fluorescence-guided surgery." C&EN Global Enterprise 98, no. 38 (2020): 11. http://dx.doi.org/10.1021/cen-09838-scicon5.

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Zhang, Qimei, Stephen P. Morgan, Paul O’Shea, and Melissa L. Mather. "Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents." PLOS ONE 11, no. 7 (2016): e0159742. http://dx.doi.org/10.1371/journal.pone.0159742.

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Laramie, Matt, Mary Smith, Fahad Marmarchi, Lacey McNally, and Maged Henary. "Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging." Molecules 23, no. 11 (2018): 2766. http://dx.doi.org/10.3390/molecules23112766.

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Almost every variety of medical imaging technique relies heavily on exogenous contrast agents to generate high-resolution images of biological structures. Organic small molecule contrast agents, in particular, are well suited for biomedical imaging applications due to their favorable biocompatibility and amenability to structural modification. PET/SPECT, MRI, and fluorescence imaging all have a large host of small molecule contrast agents developed for them, and there exists an academic understanding of how these compounds can be developed. Optoacoustic imaging is a relatively newer imaging te

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Sevick-Muraca, Eva M., Jessica P. Houston, and Michael Gurfinkel. "Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents." Current Opinion in Chemical Biology 6, no. 5 (2002): 642–50. http://dx.doi.org/10.1016/s1367-5931(02)00356-3.

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NOTHDURFT, R., P. SARDER, S. BLOCH, J. CULVER, and S. ACHILEFU. "Fluorescence lifetime imaging microscopy using near-infrared contrast agents." Journal of Microscopy 247, no. 2 (2012): 202–7. http://dx.doi.org/10.1111/j.1365-2818.2012.03634.x.

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CHEN, CHAO-WEI, TIFFANY R. BLACKWELL, RENEE NAPHAS, et al. "DEVELOPMENT OF NEEDLE-BASED MICROENDOSCOPY FOR FLUORESCENCE MOLECULAR IMAGING OF BREAST TUMOR MODELS." Journal of Innovative Optical Health Sciences 02, no. 04 (2009): 343–52. http://dx.doi.org/10.1142/s1793545809000747.

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Fluorescence molecular imaging enables the visualization of basic molecular processes such as gene expression, enzyme activity, and disease-specific molecular interactions in vivo using targeted contrast agents, and therefore, is being developed for early detection and in situ characterization of breast cancers. Recent advances in developing near-infrared fluorescent imaging contrast agents have enabled the specific labeling of human breast cancer cells in mouse model systems. In synergy with contrast agent development, this paper describes a needle-based fluorescence molecular imaging device

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Saladino, Giovanni M., Nuzhet I. Kilic, Bertha Brodin, et al. "Carbon Quantum Dots Conjugated Rhodium Nanoparticles as Hybrid Multimodal Contrast Agents." Nanomaterials 11, no. 9 (2021): 2165. http://dx.doi.org/10.3390/nano11092165.

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Nanoparticle (NP)-based contrast agents enabling different imaging modalities are sought for non-invasive bio-diagnostics. A hybrid material, combining optical and X-ray fluorescence is presented as a bioimaging contrast agent. Core NPs based on metallic rhodium (Rh) have been demonstrated to be potential X-ray Fluorescence Computed Tomography (XFCT) contrast agents. Microwave-assisted hydrothermal method is used for NP synthesis, yielding large-scale NPs within a significantly short reaction time. Rh NP synthesis is performed by using a custom designed sugar ligand (LODAN), constituting a str

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Gurfinkel, Michael, Shi Ke, Xiaoxia Wen, Chun Li, and Eva M. Sevick-Muraca. "Near-Infrared Fluorescence Optical Imaging and Tomography." Disease Markers 19, no. 2-3 (2004): 107–21. http://dx.doi.org/10.1155/2004/474818.

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The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises selective and specific molecular targeting of diseased tissues. As an example of one area of the field, recent work focusing on pharmacokinetic analysis of fluorophores targeting the epidermal growth fact

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DACOSTA, RALPH S., YING TANG, TUULA KALLIOMAKI, et al. "IN VIVO NEAR-INFRARED FLUORESCENCE IMAGING OF HUMAN COLON ADENOCARCINOMA BY SPECIFIC IMMUNOTARGETING OF A TUMOR-ASSOCIATED MUCIN." Journal of Innovative Optical Health Sciences 02, no. 04 (2009): 407–22. http://dx.doi.org/10.1142/s1793545809000759.

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Background and Aims: Accurate endoscopic detection of premalignant lesions and early cancers in the colon is essential for cure, since prognosis is closely related to lesion size and stage. Although it has great clinical potential, autofluorescence endoscopy has limited tumor-to-normal tissue image contrast for detecting small preneoplastic lesions. We have developed a molecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate which targets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescence-based endoscopy of colon cancer. Methods

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Chu, Chia-Hui, Shih-Hsun Cheng, Nai-Tzu Chen, Wei-Neng Liao, and Leu-Wei Lo. "Microwave-Synthesized Platinum-Embedded Mesoporous Silica Nanoparticles as Dual-Modality Contrast Agents: Computed Tomography and Optical Imaging." International Journal of Molecular Sciences 20, no. 7 (2019): 1560. http://dx.doi.org/10.3390/ijms20071560.

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Nanoparticle-based imaging contrast agents have drawn tremendous attention especially in multi-modality imaging. In this study, we developed mesoporous silica nanoparticles (MSNs) for use as dual-modality contrast agents for computed tomography (CT) and near-infrared (NIR) optical imaging (OI). A microwave synthesis for preparing naked platinum nanoparticles (nPtNPs) on MSNs (MSNs-Pt) was developed and characterized with physicochemical analysis and imaging systems. The high density of nPtNPs on the surface of the MSNs could greatly enhance the CT contrast. Inductively coupled plasma mass spec

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Favril, Sophie, Eline Abma, Francesco Blasi, et al. "Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology." Veterinary Record 183, no. 11 (2018): 354. http://dx.doi.org/10.1136/vr.104851.

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One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe

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Mantareva, Vanya, Daniela Petrova, Latchezar Avramov, et al. "Long wavelength absorbing cationic Zn(II)-phthalocyanines as fluorescent contrast agents for B16 pigmented melanoma." Journal of Porphyrins and Phthalocyanines 09, no. 01 (2005): 47–53. http://dx.doi.org/10.1142/s1088424605000095.

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Three cationic zinc phthalocyanines ( ZnPcs ), tetrakis-(3-methylpyridyloxy)-, tetrakis-(3-hexyl-pyridyloxy)-, and tetrakis-(3-dodecylpyridyloxy)phthalocyaninezinc ( ZnPc Me, ZnPc He and ZnPc Do) have been studied as advanced fluorescent contrast agents for pigmented melanoma tumor. UV-vis spectroscopic properties of the monomers were investigated. Their photophysical behavior as a substantial part of dye-induced fluorescence was evaluated. The selective accumulation and labeling capacity towards B16F0 pigmented melanoma tumor were determined. Melanin containing cells were isolated and incubat

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Lai, Syu-Ming, Tsiao-Yu Tsai, Chia-Yen Hsu, Jai-Lin Tsai, Ming-Yuan Liao, and Ping-Shan Lai. "Bifunctional Silica-Coated Superparamagnetic FePt Nanoparticles for Fluorescence/MR Dual Imaging." Journal of Nanomaterials 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/631584.

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Recently, superparamagnetic chemically disordered face-centered cubic (fcc) FePt nanoparticles have been demonstrated as superior negative contrast agents for magnetic resonance imaging (MRI). However, their low intracellular labeling efficiency has limited the potential usage and the nanotoxicity of the particles requires attention. We have developed fluorescein isothiocyanate-incorporated silica-coated FePt (FePt@SiO2-FITC) nanoparticles that exhibited not only a significantT1andT2MR contrast abilities but also a fluorescent property without significant cytotoxicities. These results suggest

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Luo, Dong, Xinning Wang, Clemens Burda, and James P. Basilion. "Recent Development of Gold Nanoparticles as Contrast Agents for Cancer Diagnosis." Cancers 13, no. 8 (2021): 1825. http://dx.doi.org/10.3390/cancers13081825.

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The last decade has witnessed the booming of preclinical studies of gold nanoparticles (AuNPs) in biomedical applications, from therapeutics delivery, imaging diagnostics, to cancer therapies. The synthetic versatility, unique optical and electronic properties, and ease of functionalization make AuNPs an excellent platform for cancer theranostics. This review summarizes the development of AuNPs as contrast agents to image cancers. First, we briefly describe the AuNP synthesis, their physical characteristics, surface functionalization and related biomedical uses. Then we focus on the performanc

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Roorda, Robert D., Tobias M. Hohl, Ricardo Toledo-Crow, and Gero Miesenböck. "Video-Rate Nonlinear Microscopy of Neuronal Membrane Dynamics With Genetically Encoded Probes." Journal of Neurophysiology 92, no. 1 (2004): 609–21. http://dx.doi.org/10.1152/jn.00087.2004.

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Biological membranes decorated with suitable contrast agents give rise to nonlinear optical signals such as two-photon fluorescence and harmonic up-conversion when illuminated with ultra-short, high-intensity pulses of infrared laser light. Microscopic images based on these nonlinear contrasts were acquired at video or higher frame rates by scanning a focused illuminating spot rapidly across neural tissues. The scan engine relied on an acousto-optic deflector (AOD) to produce a fast horizontal raster and on corrective prisms to offset the AOD-induced dispersion of the ultra-short excitation li

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Zhao, Xinyu, Shuqing He, and Mei Chee Tan. "Advancements in infrared imaging platforms: complementary imaging systems and contrast agents." Journal of Materials Chemistry B 5, no. 23 (2017): 4266–75. http://dx.doi.org/10.1039/c7tb00123a.

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Recent advancements in the design of complementary infrared (IR) fluorescence imaging systems and IR-emitting contrast agents are highlighted. The ability to maximize the full performance of any IR imaging platform relies on the thorough understanding of the requirements of the imaging system and physical characteristics of the complementary contrast agents.

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De Jesus, Elizabeth, Jane J. Keating, Sumith A. Kularatne, et al. "Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging." International Journal of Molecular Imaging 2015 (September 28, 2015): 1–10. http://dx.doi.org/10.1155/2015/469047.

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Background. Intraoperative imaging can identify cancer cells in order to improve resection; thus fluorescent contrast agents have emerged. Our objective was to do a preclinical comparison of two fluorescent dyes, EC17 and OTL38, which both target folate receptor but have different fluorochromes. Materials. HeLa and KB cells lines were used for in vitro and in vivo comparisons of EC17 and OTL38 brightness, sensitivity, pharmacokinetics, and biodistribution. In vivo experiments were then performed in mice. Results. The peak excitation and emission wavelengths of EC17 and OTL38 were 470/520 nm an

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Ohnishi, Shunsuke, Stephen J. Lomnes, Rita G. Laurence, Andrew Gogbashian, Giuliano Mariani, and John V. Frangioni. "Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping." Molecular Imaging 4, no. 3 (2005): 153535002005051. http://dx.doi.org/10.1162/15353500200505127.

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Intraoperative near-infrared (NIR) fluorescence imaging provides the surgeon with real-time image guidance during cancer and other surgeries. We have previously reported the use of NIR fluorescent quantum dots (QDs) for sentinel lymph node (SLN) mapping. However, because of concerns over potential toxicity, organic alternatives to QDs will be required for initial clinical studies. We describe a family of 800 nm organic heptamethine indocyanine-based contrast agents for SLN mapping spanning a spectrum from 775 Da small molecules to 7 MDa nanocolloids. We provide a detailed characterization of t

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Kobayashi, H., M. Ogawa, N. Kosaka, et al. "CMR2009: 2.01: Designing cancer cell-specific fluorescence contrast agents: a flexible approach." Contrast Media & Molecular Imaging 4, no. 6 (2009): 263–64. http://dx.doi.org/10.1002/cmmi.304.

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Carr, Jessica A., Daniel Franke, Justin R. Caram, et al. "Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green." Proceedings of the National Academy of Sciences 115, no. 17 (2018): 4465–70. http://dx.doi.org/10.1073/pnas.1718917115.

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Fluorescence imaging is a method of real-time molecular tracking in vivo that has enabled many clinical technologies. Imaging in the shortwave IR (SWIR; 1,000–2,000 nm) promises higher contrast, sensitivity, and penetration depths compared with conventional visible and near-IR (NIR) fluorescence imaging. However, adoption of SWIR imaging in clinical settings has been limited, partially due to the absence of US Food and Drug Administration (FDA)-approved fluorophores with peak emission in the SWIR. Here, we show that commercially available NIR dyes, including the FDA-approved contrast agent ind

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Li, Yuyang, Kian Shaker, Jakob C. Larsson, Carmen Vogt, Hans M. Hertz, and Muhammet S. Toprak. "A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging." Contrast Media & Molecular Imaging 2018 (December 27, 2018): 1–7. http://dx.doi.org/10.1155/2018/8174820.

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Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally matched K-shell absorption for the laboratory scale X-ray source. The K-shell emissions of these NPs

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Carlson, Alicia L., Ann M. Gillenwater, Michelle D. Williams, Adel K. El-Naggar, and R. R. Richards-Kortum. "Confocal Microscopy and Molecular-Specific Optical Contrast Agents for the Detection of Oral Neoplasia." Technology in Cancer Research & Treatment 6, no. 5 (2007): 361–74. http://dx.doi.org/10.1177/153303460700600501.

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Using current clinical diagnostic techniques, it is difficult to visualize tumor morphology and architecture at the cellular level, which is necessary for diagnostic localization of pathologic lesions. Optical imaging techniques have the potential to address this clinical need by providing real-time, sub-cellular resolution images. This paper describes the use of dual mode confocal microscopy and optical molecular-specific contrast agents to image tissue architecture, cellular morphology, and sub-cellular molecular features of normal and neoplastic oral tissues. Fresh tissue slices were prepar

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Sun, Jiantang, Kun Fu, Ming-Qiang Zhu, Lissett Bickford, Eric Post, and Rebekah Drezek. "Near-Infrared Quantum Dot Contrast Agents for Fluorescence Tissue Imaging: A Phantom Study." Current Nanoscience 5, no. 2 (2009): 160–66. http://dx.doi.org/10.2174/157341309788185433.

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Demos, S. G., W. B. Wang, and R. R. Alfano. "Imaging objects hidden in scattering media with fluorescence polarization preservation of contrast agents." Applied Optics 37, no. 4 (1998): 792. http://dx.doi.org/10.1364/ao.37.000792.

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Kotková, Zuzana, Jan Kotek, Daniel Jirák, et al. "Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging." Chemistry - A European Journal 16, no. 33 (2010): 10094–102. http://dx.doi.org/10.1002/chem.200903519.

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Endres, Paul J., Keith W. MacRenaris, Stefan Vogt, Matthew J. Allen, and Thomas J. Meade. "Quantitative Imaging of Cell-Permeable Magnetic Resonance Contrast Agents Using X-Ray Fluorescence." Molecular Imaging 5, no. 4 (2006): 7290.2006.00026. http://dx.doi.org/10.2310/7290.2006.00026.

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Payne, William M., Tanner K. Hill, Denis Svechkarev, Megan B. Holmes, Balasrinivasa R. Sajja, and Aaron M. Mohs. "Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging." Contrast Media & Molecular Imaging 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/9616791.

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Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanc

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Baranowska-Korczyc, Anna, Małgorzata Jasiurkowska-Delaporte, Barbara M. Maciejewska, et al. "PEG–MWCNT/Fe hybrids as multi-modal contrast agents for MRI and optical imaging." RSC Advances 6, no. 55 (2016): 49891–902. http://dx.doi.org/10.1039/c6ra09191a.

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This study examines the use of oxidized multi-walled carbon nanotube/iron (O-MWCNT/Fe) nanohybrids modified with polyethylene glycol (PEG) as multifunctional cellular imaging agents for magnetic resonance imaging (MRI) and fluorescence microscopy.

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Luo, Ningqi, Chuan Yang, Xiumei Tian, et al. "A general top-down approach to synthesize rare earth doped-Gd2O3 nanocrystals as dualmodal contrast agents." J. Mater. Chem. B 2, no. 35 (2014): 5891–97. http://dx.doi.org/10.1039/c4tb00695j.

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A general strategy, combining laser ablation in liquid with a standard solid state reaction technique, is developed to prepare dualmodal contrast agents for fluorescence and magnetic resonance imaging applications.

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Tan, Yiyong, Zehong Cao, Hari Krishna Sajja, et al. "DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging." Journal of X-Ray Science and Technology 21, no. 1 (2013): 43–52. http://dx.doi.org/10.3233/xst-130365.

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Yu, Ming-Xia, Jiao-Jiao Ma, Jia-Mei Wang, et al. "Ag2Te Quantum Dots as Contrast Agents for Near-Infrared Fluorescence and Computed Tomography Imaging." ACS Applied Nano Materials 3, no. 6 (2020): 6071–77. http://dx.doi.org/10.1021/acsanm.0c01274.

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Bingbing Cheng, Ming-Yuan Wei, Yuan Liu, et al. "Development of Ultrasound-Switchable Fluorescence Imaging Contrast Agents Based on Thermosensitive Polymers and Nanoparticles." IEEE Journal of Selected Topics in Quantum Electronics 20, no. 3 (2014): 67–80. http://dx.doi.org/10.1109/jstqe.2013.2280997.

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Fortin, Pierre-Yves, Coralie Genevois, Anne Koenig, Emilie Heinrich, Isabelle Texier, and Franck Couillaud. "Detection of brain tumors using fluorescence diffuse optical tomography and nanoparticles as contrast agents." Journal of Biomedical Optics 17, no. 12 (2012): 126004. http://dx.doi.org/10.1117/1.jbo.17.12.126004.

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Hockenberry, Mark S., Zachary L. Smith, and Phillip Mucksavage. "A Novel Use of Near-Infrared Fluorescence Imaging During Robotic Surgery Without Contrast Agents." Journal of Endourology 28, no. 5 (2014): 509–12. http://dx.doi.org/10.1089/end.2013.0606.

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Zhang, Chris J., Michael S. Valic, Juan Chen, and Gang Zheng. "In Vivo Potential of Manganese Chelated Porphysomes as MRI Contrast Agents." STEM Fellowship Journal 3, no. 1 (2017): 47–53. http://dx.doi.org/10.17975/sfj-2017-007.

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Porphysome nanoparticles are composed of porphyrin-conjugated lipids. The attachment of the porphyrin moiety to each phospholipid confers novel properties to the liposome-like nanoparticle, allowing it to perform a variety of diagnostic and therapeutic applications. The metal chelating properties of porphyrin can be used to bind manganese (Mn), transforming the porphysome into a contrast agent for magnetic resonance imaging (MRI). Previous work has extensively characterized the properties of the Mn-porphysome. Herein, we build upon that work by demonstrating the bio-interactions of Mn-porphyso

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Yu, Zhi, Michael Grafe, Heike Meyborg, Eckart Fleck, and Yangqiu Li. "In Vitro Characterization of Magnetic Resonance Imaging Contrast Agents for Molecular Imaging." Blood 108, no. 11 (2006): 3944. http://dx.doi.org/10.1182/blood.v108.11.3944.3944.

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Abstract The aim of this work was to evaluate the biological properties of one citrate-coated and two different dextran-coated paramagnetic particles with comparable size (iron core 4–10 nm). Endothelial cells from humans and mice as well as human macrophages were incubated for different time intervals with different particle suspensions. The cellular uptake was semi-quantitatively measured using the Prussian blue staining and, in addition, by cellular iron content. Furthermore the effect of known inhibitors of endocytosis was evaluated. In addition, it was evaluated whether linking of monoclo

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Zhu, Qin, Fei Pan, Yu Tian, Weijun Tang, Yuan Yuan, and Aiguo Hu. "Facile synthesis of Gd(iii) metallosurfactant-functionalized carbon nanodots with high relaxivity as bimodal imaging probes." RSC Advances 6, no. 35 (2016): 29441–47. http://dx.doi.org/10.1039/c6ra02654k.

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Lesniak, Wojciech G., Yixuan Wu, Jeeun Kang, et al. "Dual contrast agents for fluorescence and photoacoustic imaging: evaluation in a murine model of prostate cancer." Nanoscale 13, no. 20 (2021): 9217–28. http://dx.doi.org/10.1039/d1nr00669j.

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Keahey, Pelham, Preetha Ramalingam, Kathleen Schmeler, and Rebecca R. Richards-Kortum. "Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents." Proceedings of the National Academy of Sciences 113, no. 39 (2016): 10769–73. http://dx.doi.org/10.1073/pnas.1613497113.

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Fiber optic microendoscopy has shown promise for visualization of molecular contrast agents used to study disease in vivo. However, fiber optic microendoscopes have limited optical sectioning capability, and image contrast is limited by out-of-focus light generated in highly scattering tissue. Optical sectioning techniques have been used in microendoscopes to remove out-of-focus light but reduce imaging speed or rely on bulky optical elements that prevent in vivo imaging. Here, we present differential structured illumination microendoscopy (DSIMe), a fiber optic system that can perform structu

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Fixler, Dror, Chen Tzur, and Zeev Zalevsky. "Genetic Algorithm-Based Design for Metal-Enhanced Fluorescent Nanostructures." Materials 12, no. 11 (2019): 1766. http://dx.doi.org/10.3390/ma12111766.

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In this paper, we present our optimization tool for fluorophore-conjugated metal nanostructures for the purpose of designing novel contrast agents for multimodal bioimaging. Contrast agents are of great importance to biological imaging. They usually include nanoelements causing a reduction in the need for harmful materials and improvement in the quality of the captured images. Thus, smart design tools that are based on evolutionary algorithms and machine learning definitely provide a technological leap in the fluorescence bioimaging world. This article proposes the usage of properly designed m

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Ma, Jiao-Jiao, Ming-Xia Yu, Zheng Zhang, et al. "Gd-DTPA-coupled Ag2Se quantum dots for dual-modality magnetic resonance imaging and fluorescence imaging in the second near-infrared window." Nanoscale 10, no. 22 (2018): 10699–704. http://dx.doi.org/10.1039/c8nr02017e.

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Xu, Hao, Yubin Liu, Junle Qu, and Zhen Yuan. "PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy." Journal of Innovative Optical Health Sciences 12, no. 03 (2019): 1941003. http://dx.doi.org/10.1142/s1793545819410037.

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The photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics. In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A (BPD) were examined and compared with that from the other PSs and dyes such as TPPS4, Cy5 dye and ICG. We discovered that BPD exhibited its advantage as contrast agent for PAI. Meanwhile, BPD can also serve as the contrast agent for enhanced FLI. In particular, the PEGylated nanoliposome (PNL) encap

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Guo, Jinzhu, Hua Yue, Yanjun Wang, and Xiujuan Du. "Evaluation Preparation of Apatinib-Loaded Polymer Nanoparticles and Its Effect in the Treatment of Advanced Ovarian Cancer." Journal of Nanoscience and Nanotechnology 21, no. 2 (2021): 1212–19. http://dx.doi.org/10.1166/jnn.2021.18669.

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Ovarian cancer is a common gynecological malignant tumor, second only to cervical cancer and uterine body cancer. In China, ovarian cancer has the highest mortality rate in gynecological tumors. Due to the rapid spread of cancer cells, the prognosis is relatively poor. Because the ovarian epithelial cancer is relatively insidious, there are no obvious clinical manifestations in the early stage. At present, apatinib chemotherapy is widely used, which can reduce the disease of patients by inhibiting the migration and proliferation of vascular endothelial cells. Fluorescence imaging is widely use

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Akers, Walter J., Mikhail Y. Berezin, Hyeran Lee, and Samuel Achilefu. "Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements." Journal of Biomedical Optics 13, no. 5 (2008): 054042. http://dx.doi.org/10.1117/1.2982535.

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Jiang, Yuyan, and Kanyi Pu. "Molecular Fluorescence and Photoacoustic Imaging in the Second Near‐Infrared Optical Window Using Organic Contrast Agents." Advanced Biosystems 2, no. 5 (2018): 1700262. http://dx.doi.org/10.1002/adbi.201700262.

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Zhang, Qimei, Anna M. Grabowska, Philip A. Clarke, and Stephen P. Morgan. "Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging." Journal of Imaging 5, no. 11 (2019): 83. http://dx.doi.org/10.3390/jimaging5110083.

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The spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations have been investigated. In this paper, the influence of the light wavelength and imaging configurations (full-field illumination system and scanning system) on fluorescence imaging are compared quantitatively. The surface radiance for both systems is calculated by modifying the simulation tool Near-Infrared Fluorescence and Spectral Tomography. Fluorescent

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Zhang, Mingming, Shuya Li, Xuzhou Yan, et al. "Fluorescent metallacycle-cored polymers via covalent linkage and their use as contrast agents for cell imaging." Proceedings of the National Academy of Sciences 113, no. 40 (2016): 11100–11105. http://dx.doi.org/10.1073/pnas.1612898113.

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The covalent linkage of supramolecular monomers provides a powerful strategy for constructing dynamic polymeric materials whose properties can be readily tuned either by the selection of monomers or the choice of functional linkers. In this strategy, the stabilities of the supramolecular monomers and the reactions used to link the monomers are crucial because such monomers are normally dynamic and can disassemble during the linking process, leading to mixture of products. Therefore, although noncovalent interactions have been widely introduced into metallacycle structures to prepare metallosup

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Tansi, Felista L., Ronny Rüger, Ansgar M. Kollmeier, et al. "Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes." Pharmaceutics 12, no. 4 (2020): 370. http://dx.doi.org/10.3390/pharmaceutics12040370.

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Liposomes are biocompatible nanocarriers with promising features for targeted delivery of contrast agents and drugs into the tumor microenvironment, for imaging and therapy purposes. Liposome-based simultaneous targeting of tumor associated fibroblast and the vasculature is promising, but the heterogeneity of tumors entails a thorough validation of suitable markers for targeted delivery. Thus, we elucidated the potential of bispecific liposomes targeting the fibroblast activation protein (FAP) on tumor stromal fibroblasts, together with endoglin which is overexpressed on tumor neovascular cell

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Linsler, S., S. Senger, S. Müller, A. Müller, and J. Oertel. "OS06.5A Fluorescence image-guided resection of intracranial meningioma: an experimental in vivo study on nude mice." Neuro-Oncology 23, Supplement_2 (2021): ii9—ii10. http://dx.doi.org/10.1093/neuonc/noab180.029.

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Abstract BACKGROUND The use of photodynamic agents in malignant cranial tumor surgery is quite common. For example five-aminolevulinic acid (5-ALA)-induced porphyrins in malignant gliomas are potent photosensitizers. Until today there is no comparable selective fluorescent substance available for meningiomas. Nevertheless, there is a demand for intraoperative fluorescent identification of e.g. invasive skull base meningiomas to increase radicality. This study was established to investigate fluorescent image-guided resection with somatostatin receptor labelled fluorescence dye for intracranial

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Fei-Peng, Zhu, Chen Guo-Tao, Wang Shou-Ju, et al. "Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles." Journal of Nanomaterials 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/6502127.

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Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs

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