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Journal articles on the topic 'Fluorescent nanoprobes'

Author: Grafiati

Published: 25 January 2025

Last updated: 31 July 2025

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1

Yuan, Huanxiang, Yutong Li, Jiaqi Lv, et al. "Recent Advances in Fluorescent Nanoprobes for Food Safety Detection." Molecules 28, no. 14 (2023): 5604. http://dx.doi.org/10.3390/molecules28145604.

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Fluorescent nanoprobes show similar fluorescence properties to traditional organic dyes, but the addition of nanotechnology accurately controls the size, shape, chemical composition, and surface chemistry of the nanoprobes with unique characteristics and properties, such as bright luminescence, high photostability, and strong biocompatibility. For example, modifying aptamers or antibodies on a fluorescent nanoprobe provides high selectivity and specificity for different objects to be tested. Fluorescence intensity, life, and other parameters of targets can be changed by different sensing mecha

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2

Zha, Yiqian, Xinyuan Cui, Yanlei Liu, et al. "Two-Photon Nanoprobe for NIR-II Imaging of Tumour and Biosafety Evaluation." Journal of Biomedical Nanotechnology 18, no. 3 (2022): 807–17. http://dx.doi.org/10.1166/jbn.2022.3275.

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How to develop near-infrared second window (NIR-II, 1000–1700 nm) fluorescent nanoprobes with a uniform size, strong fluorescence signal and good biosafety owns great clinical requirement. Herein we reported that a two photon fluorescent nanoprobe was developed via encapsulating NIR-II-fluorescent molecules into DSPE-PEG, which was effectively endocytosized by cancer cells, and achieved strong NIR-II fluorescence imaging in cancer cells and cancer cell-beard mice models. Prepared NIR-II-fluorescent nanoprobe exhibited rapid metabolism and excellent biocompatibility. In conclusion, the prepared

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3

Wang, Xiao-Lin, Xiao Han, Xiao-Ying Tang, Xiao-Jun Chen, and Han-Jun Li. "A Review of Off–On Fluorescent Nanoprobes: Mechanisms, Properties, and Applications." Journal of Biomedical Nanotechnology 17, no. 7 (2021): 1249–72. http://dx.doi.org/10.1166/jbn.2021.3117.

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With the development of nanomaterials, fluorescent nanoprobes have attracted enormous attention in the fields of chemical sensing, optical materials, and biological detection. In this paper, the advantages of “off–on” fluorescent nanoprobes in disease detection, such as high sensitivity and short response time, are attentively highlighted. The characteristics, sensing mechanisms, and classifications of disease-related target substances, along with applications of these nanoprobes in cancer diagnosis and therapy are summarized systematically. In addition, the prospects of “off–on” fluorescent n

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4

Boukari, Hacène, Candida Silva, Ralph Nossal, and Ferenc Horkay. "Nanoprobe Diffusion in Poly(Vinyl-alcohol) Gels and Solutions: Effects of pH and Dehydration." MRS Proceedings 1622 (2014): 135–45. http://dx.doi.org/10.1557/opl.2014.74.

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ABSTRACTWe report fluorescence correlation spectroscopy (FCS) measurements of the translational diffusion of two fluorescent nanoprobes, rhodamine (R6G) and carboxytetramethylrhodamine (TAMRA), embedded in poly(vinyl alcohol) (PVA) solutions and gels. The diffusion coefficient was measured as a function of the PVA concentration and pH. Furthermore, we designed and built an optical chamber to determine the diffusion coefficient of the nanoprobes within the PVA solutions and gels subjected to controlled dehydration. We find that 1) lowering pH causes an apparent slowing down of the diffusion of

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Dai, Li, Wenjun Wang, Jie Yan, and Yong Liu. "Novel Synthesis of Fluorescein Isothiocyanate-Based Fluorescent Nanoprobes in Imaging Lung Inflammation." Journal of Biomedical Nanotechnology 20, no. 4 (2024): 615–27. http://dx.doi.org/10.1166/jbn.2024.3795.

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We aimed to examine the novel synthesis of fluorescent nanoprobes synthesized in imaging lung inflammation and diseased tissues. All reagents were purchased from commercial suppliers to synthesize the PLGA, PEG, GFP, RFP, rhodamine, and magnetic fluorescent nanoprobes. We performed experiments using human lung cells from the Chinese Academy of Medical Sciences Cell Center. The cells were cultured in a DMEM medium. Confocal microscopy was used to label the cells during imaging. All statistical analyses were performed in GraphPad Prism. There were significant differences in the fluorescent inten

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Chen, Jingyao, Dan Li, Chenqi Zhou, et al. "Principle Superiority and Clinical Extensibility of 2D and 3D Charged Nanoprobe Detection Platform Based on Electrophysiological Characteristics of Circulating Tumor Cells." Cells 12, no. 2 (2023): 305. http://dx.doi.org/10.3390/cells12020305.

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The electrical characteristic of cancer cells is neglected among tumor biomarkers. The development of nanoprobes with opposing charges for monitoring the unique electrophysiological characteristics of cancer cells. Micro-nano size adsorption binding necessitates consideration of the nanoprobe’s specific surface area. On the basis of the electrophysiological characteristics of circulating tumor cells (CTCs), clinical application and performance assessment are determined. To demonstrate that cancer cells have a unique pattern of electrophysiological patterns compared to normal cells, fluorescent

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7

Lee, Wang Sik, Soohyun Lee, Taejoon Kang, Choong-Min Ryu, and Jinyoung Jeong. "Detection of Ampicillin-Resistant E. coli Using Novel Nanoprobe-Combined Fluorescence In Situ Hybridization." Nanomaterials 9, no. 5 (2019): 750. http://dx.doi.org/10.3390/nano9050750.

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Antibiotic-resistant bacteria present a global threat because the infections they cause are difficult to treat. Therefore, it is highly important to develop advanced methods for the identification of antibiotic resistance gene in the virulent bacteria. Here, we report the development of novel nanoprobes for fluorescence in situ hybridization (FISH) and the application of the nanoprobe to the detection of ampicillin-resistant Escherichia coli. The nanoprobe for FISH was synthesized by the modified sol–gel chemistry and the synthesized nanoprobe provided strong fluorescent signals and pH stabili

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8

Liu, Jiyin, Xiaochun Xie, Junna Lu, Yi He, Dan Shao, and Fangman Chen. "Self-Assembled Ru(II)-Coumarin Complexes for Selective Cell Membrane Imaging." Pharmaceutics 14, no. 11 (2022): 2284. http://dx.doi.org/10.3390/pharmaceutics14112284.

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The cell membrane, as the protecting frontier of cells, is closely related to crucial biological behaviors including cell growth, death, and division. Lots of fluorescent probes have been fabricated to monitor cell membranes due to their simplicity and intuitiveness. However, the efficiency of those traditional probes has been limited by their susceptibility to photobleaching and poor water solubility. In this study, we have reported Ru(II)-coumarin complexes consisting of ruthenium, 1,10-phenanthroline, and coumarin 6 to further form self-assembled nanoprobes, for cell membrane targeting and

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9

Feng, Zhenzhen, Yanyun Ma, Bingjie Li, et al. "Mitochondria targeted self-assembled ratiometric fluorescent nanoprobes for pH imaging in living cells." Analytical Methods 11, no. 15 (2019): 2097–104. http://dx.doi.org/10.1039/c9ay00473d.

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10

Zhu, Koujun, Rongguo Lu, Weifeng Qu, et al. "Novel Au–Se Nanoprobes for Specific Thrombin Detection in Diagnosis of Lung Cancer." Journal of Biomedical Nanotechnology 18, no. 4 (2022): 976–85. http://dx.doi.org/10.1166/jbn.2022.3302.

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Thrombin is associated with malignant tumors and promotes tumor development, metastasis, and angiogenesis, therefore its identification especially in lung cancer cells is crucial. Because the interference of in vivo biothiols caused false positive findings with prior gold fluorescent nanoprobes, in this manuscript, an Au-selenol(Se) nanoprobe (5-FAM-peptide-Se-AuNPs) that could specifically detect thrombin was designed and compared to traditional Au–S nanoprobes. For reaching this goal, fluorophore-bearing thrombin-specific peptide containing selenol at the end was synthesized. The nanoprobe m

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11

Song, Lina, Shuai Ren, Yali Yue, Ying Tian, and Zhongqiu Wang. "A Gold Nanocage Probe Targeting Survivin for the Diagnosis of Pancreatic Cancer." Pharmaceutics 15, no. 5 (2023): 1547. http://dx.doi.org/10.3390/pharmaceutics15051547.

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In this paper, Au nanocages (AuNCs) loaded with the MRI contrast agent gadolinium (Gd) and capped with the tumor-targeting gene survivin (Sur–AuNC•Gd–Cy7 nanoprobes) were designed and applied as a targeted imaging agent for pancreatic cancer. With its capacity to transport fluorescent dyes and MR imaging agents, the gold cage is an outstanding platform. Furthermore, it has the potential to transport different drugs in the future, making it a unique carrier platform. The utilization of Sur–AuNC•Gd–Cy7 nanoprobes has proven to be an effective means of targeting and localizing survivin-positive B

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Jarosova, Romana, Sarah K. Woolfolk, Noraida Martinez-Rivera, et al. "Spatiotemporal Imaging of Zinc Ions in Zebrafish Live Brain Tissue Enabled by Fluorescent Bionanoprobes." Molecules 28, no. 5 (2023): 2260. http://dx.doi.org/10.3390/molecules28052260.

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The zebrafish is a powerful model organism to study the mechanisms governing transition metal ions within whole brain tissue. Zinc is one of the most abundant metal ions in the brain, playing a critical pathophysiological role in neurodegenerative diseases. The homeostasis of free, ionic zinc (Zn2+) is a key intersection point in many of these diseases, including Alzheimer’s disease and Parkinson’s disease. A Zn2+ imbalance can eventuate several disturbances that may lead to the development of neurodegenerative changes. Therefore, compact, reliable approaches that allow the optical detection o

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Du, Xinfeng, Niping Li, Qinghan Chen, Zeying Wu, Jingying Zhai, and Xiaojiang Xie. "Perspective on fluorescence cell imaging with ionophore-based ion-selective nano-optodes." Biomicrofluidics 16, no. 3 (2022): 031301. http://dx.doi.org/10.1063/5.0090599.

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Inorganic ions are ubiquitous in all kinds of cells with highly dynamic spatial and temporal distribution. Taking advantage of different types of fluorescent probes, fluorescence microscopic imaging and quantitative analysis of ion concentrations in cells have rapidly advanced. A family of fluorescent nanoprobes based on ionophores has emerged in recent years with the potential to establish a unique platform for the analysis of common biological ions including Na+, K+, Ca2+, Cl−, and so on. This article aims at providing a retrospect and outlook of ionophore-based ion-selective nanoprobes and

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14

Chen, Zhe, Zhuoyi Wang, Yihua Yuan, et al. "A Target-Triggered Emission Enhancement Strategy Based on a Y-Shaped DNA Fluorescent Nanoprobe with Aggregation-Induced Emission Characteristic for microRNA Imaging in Living Cells." Molecules 28, no. 5 (2023): 2149. http://dx.doi.org/10.3390/molecules28052149.

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DNA self-assembled fluorescent nanoprobes have been developed for bio-imaging owing to their high resistance to enzyme degradation and great cellular uptake capacity. In this work, we designed a new Y-shaped DNA fluorescent nanoprobe (YFNP) with aggregation-induced emission (AIE) characteristic for microRNA imaging in living cells. With the modification of the AIE dye, the constructed YFNP had a relatively low background fluorescence. However, the YFNP could emit a strong fluorescence due to the generation of microRNA-triggered AIE effect in the presence of target microRNA. Based on the propos

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15

Sokolov, Pavel, Galina Nifontova, Pavel Samokhvalov, Alexander Karaulov, Alyona Sukhanova, and Igor Nabiev. "Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer." Pharmaceutics 15, no. 3 (2023): 946. http://dx.doi.org/10.3390/pharmaceutics15030946.

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Multiplexed fluorescent immunohistochemical analysis of breast cancer (BC) markers and high-resolution 3D immunofluorescence imaging of the tumor and its microenvironment not only facilitate making the disease prognosis and selecting effective anticancer therapy (including photodynamic therapy), but also provides information on signaling and metabolic mechanisms of carcinogenesis and helps in the search for new therapeutic targets and drugs. The characteristics of imaging nanoprobe efficiency, such as sensitivity, target affinity, depth of tissue penetration, and photostability, are determined

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16

Chen, Ying, Gege Yang, Shanshan Gao, et al. "Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes." RSC Advances 10, no. 65 (2020): 39596–600. http://dx.doi.org/10.1039/d0ra07495k.

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Highly rapid and non-enzymatic method for the detection of cholesterol was constructed based on carbon nitride quantum dots (CNQDs) as fluorescent nanoprobes. The fluorescence of CNQDs could be effectively and rapidly quenched by cholesterol.

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17

Zhang, Mingkai, Yang Gao, Jialiang Wang, et al. "Identification on Mantle Cell Lymphoma Using CD20 and CD5 Coupled Upconversion Fluorescent Nanoprobes." Journal of Nanomaterials 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/3893761.

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In order to determine a particular tumor cell via nanomaterials, we introduce the preparation of CD20 and CD5 coupled nanoprobes (denoted as CD20 and CD5 nanoprobes for convenience) and an application in identification of mantle cell lymphoma (MCL) from B-cell lymphoma. In this work, CD20 and CD5 nanoprobes were prepared by selectively oxidizing the carbon-carbon double bonds of oleate ligands on the surfaces of NaYF4:Yb3+,Tm3+ and NaYF4:Yb3+,Er3+ nanoparticles and, respectively, coupling carboxyl groups on the particles’ surfaces with CD20 and CD5 monoclonal antibodies through EDC/NHS crossli

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18

Shen, Cheng-Long, Guang-Song Zheng, Meng-Yuan Wu, et al. "Chemiluminescent carbon nanodots as sensors for hydrogen peroxide and glucose." Nanophotonics 9, no. 11 (2020): 3597–604. http://dx.doi.org/10.1515/nanoph-2020-0233.

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AbstractHydrogen peroxide (H2O2) is an important product generated in the body and related to many pathophysiological processes and glucose metabolism disorder can cause many fatal diseases in living bodies. Therefore, the sensing of H2O2 and glucose is of great significance in disease diagnostics and treatment. Fluorescent carbon dots (CDs) are one new class of nanoprobes for H2O2 and glucose. Nevertheless, the CD-based sensor is always based on its fluorescence response, which is influenced by the auto-fluorescent interference. Herein, efficient fluorescent CDs were synthesized by one-pot so

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19

Zhu, Yanli, Jikai Wang, Yiyang Sun, and Qingyun Cai. "A magneto-fluorescence bacteria assay strategy based on dual colour sulfide fluorescent nanoparticles with high near-IR conversion efficiency." Analyst 145, no. 13 (2020): 4436–41. http://dx.doi.org/10.1039/d0an00816h.

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20

Hu, Yufeng, Jie Liu, Junyu Li, Tao Chen, and Minghuo Wu. "Dual-functional imprinted magnetic nanoprobes for fluorescence detection of N-nitrosodiphenylamine." Analytical Methods 10, no. 20 (2018): 2384–89. http://dx.doi.org/10.1039/c8ay00584b.

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21

Huang, Ming, Lijun Wang, Xiaojuan Zhang, et al. "Synthesis and Characterization of Folic Acid Labeled Upconversion Fluorescent Nanoprobes for in vitro Cancer Cells Targeted Imaging." Nano 12, no. 05 (2017): 1750057. http://dx.doi.org/10.1142/s1793292017500576.

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Upconversion nanoparticles (UCNPs) are widely used in the field of biomedicine, such as biosensing, cell labeling and medical multimodal imaging because of their unique optical properties. In this paper, we demonstrated the synthesis of polyethylenimine-modified NaLuF4:Yb,Er ([Formula: see text], Yb[Formula: see text], Er[Formula: see text] UCNPs in three different solvents, such as water, ethylene glycol and diethylene glycol. The as-prepared UCNPs were characterized and the experimental results showed that the UCNPs synthesized in ethylene glycol had excellent properties. The obtained UCNPs

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22

Zhang, Ning, Yanmei Si, Zongzhao Sun, et al. "Lab-on-a-drop: biocompatible fluorescent nanoprobes of gold nanoclusters for label-free evaluation of phosphorylation-induced inhibition of acetylcholinesterase activity towards the ultrasensitive detection of pesticide residues." Analyst 139, no. 18 (2014): 4620–28. http://dx.doi.org/10.1039/c4an00855c.

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23

Sun, Lu, Shuping Xie, Xiuru Ji, et al. "MMP-2-responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging." Biomaterials Science 6, no. 10 (2018): 2619–26. http://dx.doi.org/10.1039/c8bm00593a.

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24

Jin, Cheng, Ting Fu, Ruowen Wang, et al. "Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging." Chemical Science 8, no. 10 (2017): 7082–86. http://dx.doi.org/10.1039/c7sc02819a.

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25

Wang, Min, Ke-yan Zheng, Shao-wu Lv, et al. "Preparation and characterization of universal Fe3O4@SiO2/CdTe nanocomposites for rapid and facile detection and separation of membrane proteins." New Journal of Chemistry 42, no. 7 (2018): 4981–90. http://dx.doi.org/10.1039/c7nj04484d.

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26

Diao, Juanjuan, Tingting Wang, and Li Li. "Graphene quantum dots as nanoprobes for fluorescent detection of propofol in emulsions." Royal Society Open Science 6, no. 1 (2019): 181753. http://dx.doi.org/10.1098/rsos.181753.

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We report a new fluorescent detection method for propofol based on graphene quantum dots (GQDs). Citric acid (CA) was selected as the carbon precursor, and fluorescent GQDs were prepared by carbonizing CA. The product, which efficiently quenched the fluorescence of GQDs, could be obtained through the oxidation of propofol in the presence of horseradish peroxidase and hydrogen peroxide. The fluorescence intensity ratio of GQDs ( F / F 0 ) was positively correlated with the concentration of propofol, which ranged within 5.34–89.07 mg l −1 , the limit of detection was 0.5 mg l −1 and the limit of

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27

Dunn, Bryce, Marzieh Hanafi, John Hummel, John R. Cressman, Rémi Veneziano, and Parag V. Chitnis. "NIR-II Nanoprobes: A Review of Components-Based Approaches to Next-Generation Bioimaging Probes." Bioengineering 10, no. 8 (2023): 954. http://dx.doi.org/10.3390/bioengineering10080954.

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Fluorescence and photoacoustic imaging techniques offer valuable insights into cell- and tissue-level processes. However, these optical imaging modalities are limited by scattering and absorption in tissue, resulting in the low-depth penetration of imaging. Contrast-enhanced imaging in the near-infrared window improves imaging penetration by taking advantage of reduced autofluorescence and scattering effects. Current contrast agents for fluorescence and photoacoustic imaging face several limitations from photostability and targeting specificity, highlighting the need for a novel imaging probe

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Zhu, Huarui, Liang Gao, Xinglu Jiang, et al. "Positively charged graphene oxide nanoparticle: precisely label the plasma membrane of live cell and sensitively monitor extracellular pH in situ." Chem. Commun. 50, no. 28 (2014): 3695–98. http://dx.doi.org/10.1039/c3cc49325c.

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29

Zhang, Yupu, Xinfeng Du, and Xiaojiang Xie. "Ionophore-Based Potassium Selective Fluorescent Organosilica Nano-Optodes Containing Covalently Attached Solvatochromic Dyes." Chemosensors 10, no. 1 (2022): 23. http://dx.doi.org/10.3390/chemosensors10010023.

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Fluorescent nanoprobes containing ionophores and solvatochromic dyes (SDs) were previously reported as an alternative to chromoionophore-based nano-optodes. However, the small-molecular SDs are prone to leakage and sequestration in complex samples. Here, we chemically attached the SDs to the surface of organosilica nanospheres through copper-catalyzed Click chemistry to prevent dye leakage. The nano-optodes remained well responsive to K+ even after exposure to a large amount of cation-exchange resin, which acted as a sink of the SDs. The potassium nanoprobes exhibited a dynamic range between 1

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Qi, Xiaoli, Hui Hu, Lina Liang та ін. "Fluorescence nanoprobes bearing low temperature-derived biochar nanoparticles as efficient quenchers for the detection of single-stranded DNA and 17β-estradiol and their analytical potential". RSC Advances 14, № 38 (2024): 28077–85. http://dx.doi.org/10.1039/d4ra03168g.

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31

Wu, Hao, Haidong Zhao, Xiaojie Song, Shen Li, Xiaojun Ma, and Mingqian Tan. "Self-assembly-induced near-infrared fluorescent nanoprobes for effective tumor molecular imaging." J. Mater. Chem. B 2, no. 32 (2014): 5302–8. http://dx.doi.org/10.1039/c4tb00761a.

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Chen, Yun, Jing Ye, Gang Lv, et al. "Hydrogen Peroxide and Hypochlorite Responsive Fluorescent Nanoprobes for Sensitive Cancer Cell Imaging." Biosensors 12, no. 2 (2022): 111. http://dx.doi.org/10.3390/bios12020111.

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Accurate diagnosis of cancer cells directly affects the clinical treatment of cancer and can significantly improve the therapeutic effect of cancer patients. Cancer cells have a unique microenvironment with a large amount of peroxide inside, effectively differentiated from relevant microenvironment normal cells. Therefore, designing the high-sensitive probes to recognize and distinguish the special physiological microenvironment of cancer cells can shed light on the early diagnosis of cancers. In this article, we design and construct a fluorescence (FL) contrast agent for cancer cell recogniti

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Pinkerton, Nathalie M., Céline Frongia, Valérie Lobjois, et al. "Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models." RSC Advances 6, no. 70 (2016): 65770–74. http://dx.doi.org/10.1039/c6ra09954h.

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Yanagi, Tamami, Kiichi Kaminaga, Wataru Kada, Osamu Hanaizumi, and Ryuji Igarashi. "Optimization of Wide-Field ODMR Measurements Using Fluorescent Nanodiamonds to Improve Temperature Determination Accuracy." Nanomaterials 10, no. 11 (2020): 2282. http://dx.doi.org/10.3390/nano10112282.

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Fluorescent nanodiamonds containing nitrogen-vacancy centers have attracted attention as nanoprobes for temperature measurements in microenvironments, potentially enabling the measurement of intracellular temperature distributions and temporal changes. However, to date, the time resolution and accuracy of the temperature determinations using fluorescent nanodiamonds have been insufficient for wide-field fluorescence imaging. Here, we describe a method for highly accurate wide-field temperature imaging using fluorescent nanodiamonds for optically detected magnetic resonance (ODMR) measurements.

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Khalid, Asma, and Snjezana Tomljenovic-Hanic. "Emerging Fluorescent Nanoparticles for Non-Invasive Bioimaging." Molecules 29, no. 23 (2024): 5594. http://dx.doi.org/10.3390/molecules29235594.

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Fluorescence-based techniques have great potential in the field of bioimaging and could bring tremendous progress in microbiology and biomedicine. The most essential element in these techniques is fluorescent nanomaterials. The use of fluorescent nanoparticles as contrast agents for bioimaging is a large topic to cover. The purpose of this mini-review is to give the reader an overview of biocompatible and biodegradable fluorescent nanoparticles that are emerging nanomaterials for use in fluorescent bioimaging. In addition to the biocompatibility of these nanomaterials, biodegradability is cons

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Jeong, Sanghwa. "(Invited) Performance-Based Screening of NIR Fluorescent ssDNA-SWCNT Nanosensors and Biomedical Applications." ECS Meeting Abstracts MA2025-01, no. 11 (2025): 934. https://doi.org/10.1149/ma2025-0111934mtgabs.

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The functionalization of fluorescent single-walled carbon nanotubes (SWCNTs) with biopolymers has proven to be a versatile platform for the development of biosensors targeting small molecules, proteins, and environmental factors. Our lab has studied the sequence-dependent corona phase from ssDNA and SWCNT and its capability to behave as synthetic molecular recognition moiety for biosensors and targeting probes. In the previous attempts, we’ve been utilizing the affinity-based screening and selection techniques to enrich the ssDNA-SWCNTs in terms of binding affinity to target; for example, evol

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Karabacak, Soner, Alagappan Palaniappan, Tsang Siu Hon Tony, et al. "Gadolinium and Polythiophene Functionalized Polyurea Polymer Dots as Fluoro-Magnetic Nanoprobes." Nanomaterials 12, no. 4 (2022): 642. http://dx.doi.org/10.3390/nano12040642.

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A rapid and one-pot synthesis of poly 3-thiopheneacetic acid (PTAA) functionalized polyurea polymer dots (Pdots) using polyethyleneimine and isophorone diisocyanate is reported. The one-pot mini-emulsion polymerization technique yielded Pdots with an average diameter of ~20 nm. The size, shape, and concentration of the surface functional groups could be controlled by altering the synthesis parameters such as ultrasonication time, concentration of the surfactant, and crosslinking agent, and the types of isocyanates utilized for the synthesis. Colloidal properties of Pdots were characterized usi

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Cingolani, Matteo, Liviana Mummolo, Francesca Lugli, Mirko Zaffagnini, and Damiano Genovese. "Protein aggregation detection with fluorescent macromolecular and nanostructured probes: challenges and opportunities." New Journal of Chemistry 45, no. 32 (2021): 14259–68. http://dx.doi.org/10.1039/d1nj01606g.

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Klymchenko, Andrey. "BrightSens - Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells - H2020." Impact 6 (August 1, 2017): 78–80. https://doi.org/10.5281/zenodo.5149840.

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Existing fluorescent molecular probes, due to limited brightness, do not allow imaging individual biomolecules directly in living cells, whereas bright fluorescent nanoparticles are unable to respond to single molecular stimuli and their inorganic core is not biodegradable. The aim of BrightSens is to develop ultrabright fluorescent organic nanoparticles (FONs) capable to convert single molecular stimuli into collective turn-on response of >100 encapsulated dyes, and to apply them in amplified molecular sensing of specific targets at the cell surface (receptors) and in the cytosol (mRNA). T

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Miss, Sejal P. Patil, Azam Z. Shaikh Mr., Akash S. Jain Mr., Divakar R. Patil Mr., Sameer R. Shaikh Mr., and S.P.Pawar Dr. "Review on Nanoprobe Device in Pharmaceutical." Journal of Advances in Clinical Pharmacology 1, no. 2 (2023): 21–31. https://doi.org/10.5281/zenodo.8375534.

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<em>These analysis efforts on the visualization, imaging, and detecting of diseases using nanoprobes. Different presently utilized nanoprobes are portrayed, including fluorescent nanoprobes, up change nanoparticle tests, very attractive iron oxide nanoprobes, polymer-and liposome-based nanoprobes, and others. The methods utilized to image and track single cells, tumours, cancer cells, brain disorders, and antigenic vasculature are also briefly summarized in this publication. Additionally, future research directions and current problems are highlighted. The development of stimuli-responsive, ac

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Chen, Junyu, Songsong Luo, Dazhuang Xu, et al. "Fabrication of AIE-active amphiphilic fluorescent polymeric nanoparticles through host–guest interaction." RSC Advances 6, no. 60 (2016): 54812–19. http://dx.doi.org/10.1039/c6ra08677b.

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Novel polymeric luminescent nanoprobes with aggregation induced emission (AIE) properties were fabricatedviahost–guest interaction between the β-CD pendant copolymers and adamantane-terminated AIE dye.

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Chen, Mian, Xiaoxiao He, Kemin Wang, Dinggeng He, Xiaohai Yang, and Hui Shi. "Inorganic fluorescent nanoprobes for cellular and subcellular imaging." TrAC Trends in Analytical Chemistry 58 (June 2014): 120–29. http://dx.doi.org/10.1016/j.trac.2014.03.003.

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Long, Shuangshuang, Qinglong Qiao, Fei Deng, Lu Miao, Juyoung Yoon, and Zhaochao Xu. "Self-assembling nanoprobes that display two-dimensional fluorescent signals for identification of surfactants and bacteria." Chemical Communications 55, no. 7 (2019): 969–72. http://dx.doi.org/10.1039/c8cc09544b.

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Payne, Christine K. "Fluorescent Dendritic Nanoprobes: A New Class of Fluorescent Probes for Biological Applications." Biophysical Journal 104, no. 7 (2013): 1394. http://dx.doi.org/10.1016/j.bpj.2013.01.053.

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Lettieri, Stefania, Marta d’Amora, Adalberto Camisasca, Alberto Diaspro, and Silvia Giordani. "Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics." Beilstein Journal of Nanotechnology 8 (September 7, 2017): 1878–88. http://dx.doi.org/10.3762/bjnano.8.188.

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Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a π-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylamino functionalities attached to the BODIPY core. The on/off emission of the fluorescent CNOs is fast

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Gao, Yan, Li Han, Jing Jing Liu, Xing Gao, and Wen He. "The Research Progress of Fluorescent Probes for Detection of Selenols." Key Engineering Materials 861 (September 2020): 315–19. http://dx.doi.org/10.4028/www.scientific.net/kem.861.315.

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Selenols (R-SeH) are similar to thiols , both of them are important reducing substance. Selenocysteine (Sec) and hydrogen selenide (H2Se) are two important selenols. They play a key role in cancer research and disease treatment. Recently, fluorescent probes and nanoprobes for detecting selenols have been developed rapidly because that fluorescent methods can be applied for biological imaging of cells or in vivo. Therefore, it is very important to the detect selenols. In this paper, we summarized the fluorescent probes for detecting the selenols in recent years.

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Kumar, Sushil, Ganga Ram Chaudhary, Savita Chaudhary, and Ahmad Umar. "3-Mercaptopropyl Trimethoxysilane @ Gadolinium Oxide Nanoprobes: An Effective Fluorescence-Sensing Platform for Cysteine." Coatings 12, no. 11 (2022): 1636. http://dx.doi.org/10.3390/coatings12111636.

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The current work aims to synthesize highly fluorescent and surface-functionalized gadolinium oxide nanoparticles (Gd2O3 NPs) with (3-mercaptopropyl) trimethoxysilane (MPTMS). The surface modification of Gd2O3 nanoparticles with MPTMS enhanced the stability and solubility of the nanoprobe in aqueous media. The size of the nanoprobe was controlled to 7 ± 1 nm using MPTMS coating. These valued points made the MPTMS@Gd2O3 nanoparticles as economical, highly sensitive, selective nanoprobe with a quick response time for the detection of cysteine via the simple fluorescence-based methodology. The pro

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Yu, Haijun, Chao Chen, Xiaodan Cao, Yueling Liu, Shengmin Zhou, and Ping Wang. "Ratiometric fluorescent pH nanoprobes based on in situ assembling of fluorescence resonance energy transfer between fluorescent proteins." Analytical and Bioanalytical Chemistry 409, no. 21 (2017): 5073–80. http://dx.doi.org/10.1007/s00216-017-0453-0.

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Lou, Doudou, Lin Fan, Yongxin Ji, Ning Gu, and Yu Zhang. "A signal amplifying fluorescent nanoprobe and lateral flow assay for ultrasensitive detection of cardiac biomarker troponin I." Analytical Methods 11, no. 28 (2019): 3506–13. http://dx.doi.org/10.1039/c9ay01039d.

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Sun, Qiang, Jun Yao, Shuxun Wei, Xinxing Li, and Weijun Wang. "The Value of Near-Infrared Multifunctional Nanoprobe Combined with Artificial Intelligence Microsensor Technology in Molecular Diagnosis for Gastric Cancer." Journal of Biomedical Nanotechnology 20, no. 2 (2024): 351–58. http://dx.doi.org/10.1166/jbn.2024.3769.

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Since the symptoms of early gastric cancer patients are not obvious, the majority of new gastric cancer cases are progressive gastric cancer every year. In this paper, we applied nanomedicine technology to design and prepare multifunctional nanoparticles for the diagnosis and treatment of gastric cancer. Through targeted imaging of gastric cancer, combined with phototherapy and the prepared nanoprobes are applied to the ectopic transplantation tumor model of gastric cancer. Meanwhile, a fluorescent microsensor based on graphene oxide and deoxyribonuclease is constructed in order to realize the

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