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Journal articles on the topic 'Fluorides Physiological effect'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Peckham, Stephen, and Niyi Awofeso. "Water Fluoridation: A Critical Review of the Physiological Effects of Ingested Fluoride as a Public Health Intervention." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/293019.

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Fluorine is the world’s 13th most abundant element and constitutes 0.08% of the Earth crust. It has the highest electronegativity of all elements. Fluoride is widely distributed in the environment, occurring in the air, soils, rocks, and water. Although fluoride is used industrially in a fluorine compound, the manufacture of ceramics, pesticides, aerosol propellants, refrigerants, glassware, and Teflon cookware, it is a generally unwanted byproduct of aluminium, fertilizer, and iron ore manufacture. The medicinal use of fluorides for the prevention of dental caries began in January 1945 when c

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2

Kensche, A., S. Pötschke, C. Hannig, G. Richter, W. Hoth-Hannig, and M. Hannig. "Influence of Calcium Phosphate and Apatite Containing Products on Enamel Erosion." Scientific World Journal 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/7959273.

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For the purpose of erosion prevention the present study aimed to compare the efficacy of two biomimetic products and a fluoride solution to optimize the protective properties of the pellicle. After 1 min ofin situpellicle formation on bovine enamel slabs, 8 subjects adopted CPP-ACP (GC Tooth Mousse), a mouthwash with hydroxyapatite microclusters (Biorepair), or a fluoride based mouthwash (elmex Kariesschutz) for 1 min each. Afterwards, samples were exposed in the oral cavity for 28 min. Native enamel slabs and slabs exposed to the oral cavity for 30 min without any rinse served as controls. Af

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Sauerheber, Richard. "Physiologic Conditions Affect Toxicity of Ingested Industrial Fluoride." Journal of Environmental and Public Health 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/439490.

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The effects of calcium ion and broad pH ranges on free fluoride ion aqueous concentrations were measured directly and computed theoretically. Solubility calculations indicate that blood fluoride concentrations that occur in lethal poisonings would decrease calcium below prevailing levels. Acute lethal poisoning and also many of the chronic effects of fluoride involve alterations in the chemical activity of calcium by the fluoride ion. Natural calcium fluoride with low solubility and toxicity from ingestion is distinct from fully soluble toxic industrial fluorides. The toxicity of fluoride is d

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Lisjak, Darja, Maša Vozlič, Uliana Kostiv, Daniel Horák, Boris Majaron, Slavko Kralj, Irena Zajc, Lovro Žiberna, and Maja Ponikvar-Svet. "NaYF₄-based upconverting nanoparticles with optimized phosphonate coatings for chemical stability and viability of human endothelial cells." Methods and Applications in Fluorescence 10, no. 1 (December 22, 2021): 014001. http://dx.doi.org/10.1088/2050-6120/ac41ba.

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Abstract The increasing interest in upconverting nanoparticles (UCNPs) in biodiagnostics and therapy fuels the development of biocompatible UCNPs platforms. UCNPs are typically nanocrystallites of rare-earth fluorides codoped with Yb3+ and Er3+ or Tm3+. The most studied UCNPs are based on NaYF4 but are not chemically stable in water. They dissolve significantly in the presence of phosphates. To prevent any adverse effects on the UCNPs induced by cellular phosphates, the surfaces of UCNPs must be made chemically inert and stable by suitable coatings. We studied the effect of various phosphonate

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Clarkson, B. H. "Caries Prevention Fluoride." Advances in Dental Research 5, no. 1 (December 1991): 41–45. http://dx.doi.org/10.1177/08959374910050010501.

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A clear understanding of the mechanism of action of fluoride and its pharmacokinetics would ensure appropriate clinical use of fluoride and fluoride-containing modalities. Convincing evidence exists that fluoride has a major effect on the demineralization and remineralization of dental hard tissues, and that it interferes with the acid production from "cariogenic" bacteria. However, it has also been shown to be physiologically harmful if fluoride concentrations and/or exposure periods are inappropriate. In order to establish appropriate clinical concentrations and exposure periods for fluoride

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PELC, Justyna, Beata SMOLIK, and Marcelina KRUPA-MAŁKIEWICZ. "EFFECT OF SODIUM FLUORIDE ON SOME MORPHOLOGICAL AND PHYSIOLOGICAL PARAMETERS OF 10-DAY-OLD SEEDLINGS OF VARIOUS PLANT SPECIES." Folia Pomeranae Universitatis Technologiae Stetinensis Agricultura, Alimentaria, Piscaria et Zootechnica 338, no. 44 (December 30, 2017): 151–58. http://dx.doi.org/10.21005/aapz2017.44.4.16.

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Bagmut, I. Yu, and I. L. Kolisnyk. "EFFECT OF FLUORIDE INTOXICATION ON HISTOHORMONE CONTENT IN EXPERIMENTS." Здобутки клінічної і експериментальної медицини, no. 4 (February 12, 2021): 13–16. http://dx.doi.org/10.11603/1811-2471.2020.v.i4.11751.

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Connection of work with scientific plans, topics. The work was performed in accordance with the research plan of the Kharkiv Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine and is a fragment of research work of the Department of Clinical Pathophysiology, Topographic Anatomy and Operative Surgery "Pathophysiological mechanisms of radiotoxins on the body and principles of early diagnosis 2017–2021). SUMMARY. One of the important medical and biological problems is to elucidate the physiological and molecular mechanisms of the impact of harmful environmental fa

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8

Jakubczyk, Karolina, Alicja Ligenza, Izabela Gutowska, and Katarzyna Janda-Milczarek. "Fluoride Content of Matcha Tea Depending on Leaf Harvest Time and Brewing Conditions." Nutrients 14, no. 12 (June 20, 2022): 2550. http://dx.doi.org/10.3390/nu14122550.

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Matcha, or powdered green tea (Camellia sinensis) of the Tencha type, is popular all around the world, and its consumption continues to rise. Because of its unique cultivation method, it is rich in phytochemicals and has many health-promoting properties; it contains high concentrations of polyphenols, theanine and chlorophyll. Tea, and by extension matcha, contains numerous minerals, one of which is fluorine. Under physiological conditions, this mineral plays a significant role in hard tissue mineralisation processes. However, even in low concentrations, with prolonged exposure, fluoride can a

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9

Whitford, G. M., D. W. Allmann, and A. R. Shahed. "Topical Fluorides: Effects on Physiologic and Biochemical Processes." Journal of Dental Research 66, no. 5 (May 1987): 1072–78. http://dx.doi.org/10.1177/00220345870660051801.

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10

Rodrigues, Douglas Almeida, Juliana de Fátima Sales, Sebastião Carvalho Vasconcelos Filho, Arthur Almeida Rodrigues, Eduardo Matheus Guimarães Teles, Alan Carlos Costa, Efraim Lázaro Reis, Thais Andrade de Carvalho Silva, and Caroline Müller. "Bioindicator potential of Ricinus communis to simulated rainfall containing potassium fluoride." PeerJ 8 (July 1, 2020): e9445. http://dx.doi.org/10.7717/peerj.9445.

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Background Fluoride pollution is a global problem because of its high phytotoxicity. Fluoride is released in air, water and soil through industrial processes, where it damages various plant species. Ricinus communis is widely distributed in Brazil, India and China and has been extensively used as a phytoremediation species in heavy metal-contaminated soils. However, few studies regarding the effect of air pollutants on R. communis have been published, and no information about the exposure of this species to fluoride is available. Therefore, the aim of the present study was to investigate the e

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Lima-Filho, Guilherme L., Glaydes M. T. Lima, Silvana R. F. Moreno, Luiz C. M. Aleixo, Sebastião D. Santos-Filho, Rosimeire S. Freitas, Vilma G. B. Melo, and Mario Bernardo-Filho. "Physiological (osmotic fragility) and morphological effects on red blood cells: action of phytic acid and stannous fluoride." Canadian Journal of Physiology and Pharmacology 82, no. 12 (December 1, 2004): 1091–95. http://dx.doi.org/10.1139/y04-110.

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Phytic acid occurs in foods derived from plants. We have investigated the possibility that phytic acid and stannous fluoride are capable of altering the physiological properties (osmotic fragility) and morphological properties of red blood cells (RBC). Osmotic fragility was unchanged by the presence of phytic acid and stannous fluoride in the studied concentrations, but RBC morphology was modified in the presence of the studied substances. In conclusion, the alterations to RBC morphology were not sufficient to promote modifications in osmotic fragility. Our results suggest that the chelating p

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Tanimoto, K., T. Le, L. Zhu, J. Chen, J. D. B. Featherstone, W. Li, and P. DenBesten. "Effects of Fluoride on the Interactions between Amelogenin and Apatite Crystals." Journal of Dental Research 87, no. 1 (January 2008): 39–44. http://dx.doi.org/10.1177/154405910808700106.

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Fluorosed enamel is more porous and less mineralized, possibly related to altered amelogenin-modulated crystal growth. The purpose of this study was to examine the role of fluoride in interactions between amelogenin and apatite crystals. Recombinant human amelogenin (rh174) was bound to carbonated hydroxyapatite containing various amounts of fluoride, and analyzed by protein assay, SDS PAGE, and AFM. Interactions between rh174 and fluoride were assayed by isothermal titration calorimetry (ITC). The initial binding rate of rh174, as well as total amount of rh174 bound to fluoride-containing car

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Maressa Hungria de Lima e Silva, Ingrid, Arthur Almeida Rodrigues, Juliana de Fátima Sales, Douglas Almeida Rodrigues, Sebastião Carvalho Vasconcelos Filho, Cássia Lino Rodrigues, Priscila Ferreira Batista, et al. "Fluoride effect indicators in Phaseolus vulgaris seeds and seedlings." PeerJ 10 (May 17, 2022): e13434. http://dx.doi.org/10.7717/peerj.13434.

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Background Fluoride (F) is one of the main environmental pollutants, and high concentrations are commonly detected in the air and in both surface and groundwater. However, the effects of this pollutant on seed germination and on the initial growth of crop seedlings are still poorly understood. In this context, the aim of this study was to assess morphoanatomical, physiological and biochemical fluoride effect indicators in Phaseolus vulgaris L. seeds and seedlings. Methods P. vulgaris seeds were exposed to a liquid potassium fluoride solution (KF, pH 6.0) at concentrations of 0 (control), 10, 2

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ten Cate, J. M., and J. D. B. Featherstone. "Mechanistic Aspects of the Interactions Between Fluoride and Dental Enamel." Critical Reviews in Oral Biology & Medicine 2, no. 3 (July 1991): 283–96. http://dx.doi.org/10.1177/10454411910020030101.

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For many years after the discovery of its caries preventive effect, fluoride was thought to be primarily active by lowering the solubility of the apatitic mineral phase of the dental hard tissues. Recent findings have shed new light on the mechanisms by which fluoride inhibits or delays dental caries. Fluoride present in the oral fluids alters the rate of the naturally occurring dissolution and reprecipitation processes at the tooth-oral fluid interface. Demineralization of enamel is inhibited by concentrations of fluoride in the sub-ppm range. Likewise, remineralization of incipient caries le

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15

Almeida Rodrigues, Arthur, Douglas Almeida Rodrigues, Juliana de Fátima Sales, Sebastião Carvalho Vasconcelos Filho, Alan Carlos Costa, Cássia Lino Rodrigues, Adinan Alves da Silva, Marisa Domingos, and Caroline Müller. "Morphoanatomical, Physiological, and Biochemical Indicators in Lactuca sativa L. Germination and Growth in Response to Fluoride." Plants 11, no. 23 (December 6, 2022): 3406. http://dx.doi.org/10.3390/plants11233406.

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Fluoride is one of the main phytotoxic environmental pollutants, and high concentrations (10–30 mg L−1) are commonly detected in surface and groundwater. Little, however, is known about the effects of this pollutant on crops that require irrigation during their development, which, in addition to phytotoxicity, may cause negative human health effects. Thus, the aim of this study was to characterize the effects of potassium fluoride (KF) on the germination of lettuce seeds and identify the physiological and anatomical markers of this pollutant’s action on plants exposed to it during growth. Init

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Nakada, M. T., J. M. Stadel та S. T. Crooke. "Mobilization of extracellular Ca2+ by prostaglandin F2α can be modulated by fluoride in 3T3-L1 fibroblasts". Biochemical Journal 272, № 1 (15 листопада 1990): 167–74. http://dx.doi.org/10.1042/bj2720167.

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Changes in the intracellular concentration of calcium [(Ca2+]i) have been shown to mediate the physiological effects of certain agonists. Ca2+ mobilization occurs through multiple mechanisms which involve both influx and internal release of Ca2+. Prostaglandin F2 alpha (PGF2 alpha) caused a transient mobilization of intracellular Ca2+ in 3T3-L1 fibroblasts. This effect was characterized by fluorescence measurements of trypsin-treated cells loaded with fura-2/AM. In the absence of extracellular Ca2+, the peak amount of Ca2+ mobilized by PGF2 alpha was decreased by 70%, a lag time before the ons

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17

Pan, Ye, Peng Lü, Lijing Yin, Keping Chen, and Yuanqing He. "Effect of fluoride on the proteomic profile of the hippocampus in rats." Zeitschrift für Naturforschung C 70, no. 5-6 (May 1, 2015): 151–57. http://dx.doi.org/10.1515/znc-2014-4158.

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Abstract Two-dimensional gel electrophoresis (2-DE) was used to detect fluoride-induced alterations in the proteome of the rat hippocampus. Male Sprague-Dawley rats (n=30) were subjected to treatments three weeks after weaning. Animals of the first group were injected intraperitoneally (i.p.) with aqueous NaF (20 mg/kg/body weight/day), the second group, injected with physiological saline, served as the control. After 30 days, the body weight of the fluoride-treated rats was lower than that of the control, and F– levels in serum were higher than in the control. The hippocampus was subjected to

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Silla, Josué M., Claudimar J. Duarte, Rodrigo A. Cormanich, Roberto Rittner, and Matheus P. Freitas. "Conformational analysis of 2,2-difluoroethylamine hydrochloride: double gauche effect." Beilstein Journal of Organic Chemistry 10 (April 16, 2014): 877–82. http://dx.doi.org/10.3762/bjoc.10.84.

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The gauche effect in fluorinated alkylammonium salts is well known and attributed either to an intramolecular hydrogen bond or to an electrostatic attraction between the positively charged nitrogen and the vicinal electronegative fluorine atom. This work reports the effect of adding a fluorine atom in 2-fluoroethylamine hydrochloride on the conformational isomerism of the resulting 2,2-difluoroethylamine chloride (2). The analysis was carried out using NMR coupling constants in D2O solution, in order to mimic the equilibrium conditions in a physiological medium, in the gas phase and in implici

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Anusavice, K. J. "Degradability of Dental Ceramics." Advances in Dental Research 6, no. 1 (September 1992): 82–89. http://dx.doi.org/10.1177/08959374920060012201.

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The degradation of dental ceramics generally occurs because of mechanical forces or chemical attack. The possible physiological side-effects of ceramics are their tendency to abrade opposing dental structures, the emission of radiation from radioactive components, the roughening of their surfaces by chemical attack with a corresponding increase in plaque retention, and the release of potentially unsafe concentrations of elements as a result of abrasion and dissolution. The chemical durability of dental ceramics is excellent. With the exception of the excessive exposure to acidulated fluoride,

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Mirzakarimova, Malokhat A. "COMPARATIVE ANALYSIS OF THE INFLUENCE OF COMPLEX MIXTURES OF CHEMICAL AIR POLLUTANTS ON BIOCHEMICAL, PHYSIOLOGICAL, GONADO-, EMBRYOTOXIC INDICES OF LABORATORY ANIMALS AND HYGIENIC EVALUATION OF THEIR COMBINED ACTION." Hygiene and sanitation 96, no. 6 (March 27, 2019): 528–31. http://dx.doi.org/10.18821/0016-9900-2017-96-6-528-531.

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In the paper there are presented results of experimental works on the study of the character of the combined toxic effect of various complex mixtures presenting in atmospheric air. The action of complex mixtures on the organism of laboratory animals was studied in two series of experiments. In the first series of the experiments there was investigated the combined action of sulfur dioxide, nitrogen dioxide, hydrogen fluoride and suspended substances, and in the second series of experiments - of lead acetate, formaldehyde, sulfur dioxide and ammonia.The character of the combined action of lead

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Fan, Jibiao, Ke Chen, Jilei Xu, Khaldun ABM, Yao Chen, Liang Chen, and Xuebing Yan. "Physiological effects induced by aluminium and fluoride stress in tall fescue (Festuca arundinacea Schreb)." Ecotoxicology and Environmental Safety 231 (February 2022): 113192. http://dx.doi.org/10.1016/j.ecoenv.2022.113192.

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Duncan, R. F., and J. W. Hershey. "Initiation factor protein modifications and inhibition of protein synthesis." Molecular and Cellular Biology 7, no. 3 (March 1987): 1293–95. http://dx.doi.org/10.1128/mcb.7.3.1293-1295.1987.

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The protein covalent modification state of eucaryotic initiation factors eIF-2 and eIF-4B in HeLa cells was examined after they were exposed to a variety of conditions or treatments that regulate protein synthesis. A few factors (e.g., variant pH and sodium fluoride) altered the phosphorylation state of the initiation factor proteins, but the majority (hypertonic medium, ethanol, dimethyl sulfoxide sodium selenite, sodium azide, and colchicine) had no effect on either protein. While initiation factor phosphorylation may regulate protein synthesis in response to many physiological situations, o

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Duncan, R. F., and J. W. Hershey. "Initiation factor protein modifications and inhibition of protein synthesis." Molecular and Cellular Biology 7, no. 3 (March 1987): 1293–95. http://dx.doi.org/10.1128/mcb.7.3.1293.

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The protein covalent modification state of eucaryotic initiation factors eIF-2 and eIF-4B in HeLa cells was examined after they were exposed to a variety of conditions or treatments that regulate protein synthesis. A few factors (e.g., variant pH and sodium fluoride) altered the phosphorylation state of the initiation factor proteins, but the majority (hypertonic medium, ethanol, dimethyl sulfoxide sodium selenite, sodium azide, and colchicine) had no effect on either protein. While initiation factor phosphorylation may regulate protein synthesis in response to many physiological situations, o

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Rai, L. C., Y. Husaini, and N. Mallick. "Physiological and biochemical responses of Nostoc linckia to combined effects of aluminium, fluoride and acidification." Environmental and Experimental Botany 36, no. 1 (May 1996): 1–12. http://dx.doi.org/10.1016/0098-8472(95)00049-6.

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Batra, Akriti, and Vabitha Shetty. "Non-Fluoridated Remineralising Agents - A Review of Literature." Journal of Evolution of Medical and Dental Sciences 10, no. 9 (March 1, 2021): 638–44. http://dx.doi.org/10.14260/jemds/2021/136.

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Dental caries is not merely a continuous and one-way process of demineralisation of the mineral phase, but repeated episodes of demineralisations and remineralisation. The remineralisation process is a natural repair mechanism to restore the minerals again, in ionic forms, to the hydroxyapatite (HAP) crystal lattice. It occurs under nearneutral physiological pH conditions whereby calcium and phosphate mineral ions are redeposited within the caries lesion from saliva and plaque fluid resulting in the formation of newer HAP crystals, which are larger and more resistant to acid dissolution. An in

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Kumar, Abhishek, Lallu, Munna Singh, and Krishan K. Verma. "Phytotoxicity of Fluoride in Guar (Cyamopsis tetragonoloba) Cultivars and its Effect on Morpho-Physiological and Biochemical Traits." Indian Journal of Agricultural Biochemistry 29, no. 2 (2016): 219. http://dx.doi.org/10.5958/0974-4479.2016.00035.6.

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Goenka, Shilpi, and Sanford R. Simon. "Effects of Fluoride Exposure on Primary Human Melanocytes from Dark and Light Skin." Toxics 8, no. 4 (December 2, 2020): 114. http://dx.doi.org/10.3390/toxics8040114.

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Fluoride exposure has adverse effects on human health that have been studied in vitro in cell culture systems. Melanocytes are the melanin pigment-producing cells that have a significant role in the regulation of the process of melanogenesis, which provides several health benefits. Melanocytes are present in the oral cavity, skin, brain, lungs, hair, and eyes. However, to date, there has been no study on the effects of fluoride exposure on melanocytes. Hence, in the current study, we have studied the effects of sodium fluoride (NaF) exposure on neonatal human epidermal melanocytes (HEMn) deriv

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Lv, Kui Long, Jiu Xing Zhang, Xiang Cai Meng, and Xing Yi Li. "Remineralization Effect of the Nano-HA Toothpaste on Artificial Caries." Key Engineering Materials 330-332 (February 2007): 267–70. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.267.

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The aim of this study is to describe the remineralization effect of the nano-HA toothpaste on artificial caries. The artificial dental caries is made using sour solution. The demineralized teeth specimen is put into five kinds of toothpaste solution respectively for 5 days and 10 days, which are: solution of containing needle like nano-HA, solution of containing spherical nano-HA, solution of general HA, fluorine sodium solution and physiological saline. The hardness of specimen is measured and the surface morphology is characterized by SEM. The remineralized test indicates that the nano-HA to

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Eanes, E. D., and A. W. Hailer. "The Effect of Fluoride on the Size and Morphology of Apatite Crystals Grown from Physiologic Solutions." Calcified Tissue International 63, no. 3 (September 1998): 250–57. http://dx.doi.org/10.1007/s002239900522.

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Pereda, M. D., C. Alonso, M. Gamero, J. A. del Valle, and M. Fernández Lorenzo de Mele. "Comparative study of fluoride conversion coatings formed on biodegradable powder metallurgy Mg: The effect of chlorides at physiological level." Materials Science and Engineering: C 31, no. 5 (July 2011): 858–65. http://dx.doi.org/10.1016/j.msec.2011.01.010.

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CADEFAU, Joan, Mathieu BOLLEN, and Willy STALMANS. "Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase." Biochemical Journal 322, no. 3 (March 15, 1997): 745–50. http://dx.doi.org/10.1042/bj3220745.

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Non-metabolized glucose derivatives may cause inactivation of phosphorylase but, unlike glucose, they are unable to elicit activation of glycogen synthase in isolated hepatocytes. We report here that, after the previous inactivation of phosphorylase by one of these glucose derivatives (2-deoxy-2-fluoro-α-glucosyl fluoride), glycogen synthase was progressively activated by addition of increasing concentrations of glucose. Under these conditions, the degree of activation of glycogen synthase was linearly correlated with the intracellular glucose-6-phosphate (Glc-6-P) concentration. Addition of g

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Kruse, Anne Brigitte, Nadine Schlueter, Viktoria Konstanze Kortmann, Cornelia Frese, Annette Anderson, Annette Wittmer, Elmar Hellwig, Kirstin Vach, and Ali Al-Ahmad. "Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria." Antibiotics 10, no. 5 (April 22, 2021): 481. http://dx.doi.org/10.3390/antibiotics10050481.

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The aim of this randomized, controlled clinical trial was to isolate and identify viable microorganisms in the saliva of study participants that continuously used a stannous and fluoride ion (F/Sn)-containing toothpaste and mouth rinse over a period of three years in comparison to a control group that used stannous ion free preparations (noF/Sn) over the same time period. Each group (F/Sn and noF/Sn) included 16 participants that used the respective oral hygiene products over a 36-month period. Stimulated saliva samples were collected at baseline (T0) and after 36 months (T1) from all particip

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Mao, Yupeng, Wen Yue, Tianming Zhao, MaiLun Shen, Bing Liu, and Song Chen. "A Self-Powered Biosensor for Monitoring Maximal Lactate Steady State in Sport Training." Biosensors 10, no. 7 (July 8, 2020): 75. http://dx.doi.org/10.3390/bios10070075.

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A self-powered biosensor for monitoring the maximal lactate steady state (MLSS) during exercise has been developed for intelligently assisting training system. It has been presented to create poly (vinylidene fluoride) (PVDF)/Tetrapod-shaped ZnO (T-ZnO)/enzyme-modified nanocomposite film through an efficient and cost-effective fabrication process. This sensor can be readily attached to the skin surface of the tester. Due to the piezoelectric surface coupling effect, this biosensor can monitor/sense and analyze physical information in real-time under the non-invasive condition and work independ

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Mahood, Hanaa E., and Baydaa M. Abbood. "Physiological and Histological Study of Preventive effect of Antioxidants, Selenium and Vitamin C with Garlic in Rats treated with Sodium Fluoride." Research Journal of Pharmacy and Technology 11, no. 3 (2018): 941. http://dx.doi.org/10.5958/0974-360x.2018.00174.9.

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PALAPARTI, Anuradha, Yuan LI, and Madhu B. ANAND-SRIVASTAVA. "Inhibition of atrial natriuretic peptide (ANP) C receptor expression by antisense oligodeoxynucleotides in A10 vascular smooth-muscle cells is associated with attenuation of ANP-C-receptor-mediated inhibition of adenylyl cyclase." Biochemical Journal 346, no. 2 (February 22, 2000): 313–20. http://dx.doi.org/10.1042/bj3460313.

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Atrial natriuretic peptide (ANP) mediates a variety of physiological effects through its interaction with ANP-A, ANP-B or ANP-C receptors. However, controversies exist regarding the involvement of ANP-C receptor and adenylyl cyclase/cAMP signal-transduction systems to which these receptors are coupled in mediating these responses. In the present studies, we have employed an antisense approach to eliminate the ANP-C receptor and to examine the effect of this elimination on adenylyl cyclase inhibition. An 18-mer antisense phosphorothioate oligodeoxynucleotide (OH-2) targeted at the initiation co

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Iozzo, Patricia, Panithaya Chareonthaitawee, Marco Di Terlizzi, D. John Betteridge, Ele Ferrannini, and Paolo G. Camici. "Regional myocardial blood flow and glucose utilization during fasting and physiological hyperinsulinemia in humans." American Journal of Physiology-Endocrinology and Metabolism 282, no. 5 (May 1, 2002): E1163—E1171. http://dx.doi.org/10.1152/ajpendo.00386.2001.

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We investigated the effect of insulin on total and regional myocardial blood flow (MBF) and glucose uptake (MGU) in healthy subjects (50 ± 5 yr) by means of positron emission tomography (PET) with oxygen-15-labeled water (H2 15O) and fluorine-18 labeled fluorodeoxyglucose (18FDG) before and during physiological hyperinsulinemia (40 mU · min−1 · m−2). Twelve male subjects were included in the study. During hyperinsulinemia, MBF increased from 0.91 ± 0.28 to 1.01 ± 0.31 ml · min−1 · g−1 ( n= 7 patients, P = 0.05; n = 112 regions, P < 0.005). Intersubject variability ranged from −3.0 to +41%.

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Ghantous, Hanan N., Jeanne Fernando, Scott E. Morgan, A. Jay Gandolfi, and Klaus Brandel. "Precision-cut Guinea-pig Liver Slices as a Tool for Studying the Toxicity of Volatile Anaesthetics." Alternatives to Laboratory Animals 18, no. 1_part_1 (November 1990): 191–99. http://dx.doi.org/10.1177/026119299001800120.1.

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Cultured precision-cut liver slices retain normal liver architecture and physiological biochemical functions. Hartley male guinea-pig liver slices have proven to be a good model for studying the biotransformation and toxicity of halothane. This system was used to evaluate the biotransformation and toxicity of different volatile anaesthetics (halothane, enflurane, isoflurane and sevoflurane), and compare their effects to those of new anaesthetics (desflurane). Liver slices (250–300μm thick) were incubated in sealed roller vials, containing Krebs Henseleit buffer at 37°C under 95% O2:5% CO2 atmo

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Meyer-Fernandes, José Roberto, Mario Alberto da Silva-Neto, Mirna dos Santos Soares, Eloise Fernandes, Anibal Eugênio Vercesi, and Mécia Maria de Oliveira. "Ecto-Phosphatase Activities on the Cell Surface of the Amastigote Forms of Trypanosoma cruzi." Zeitschrift für Naturforschung C 54, no. 11 (November 1, 1999): 977–84. http://dx.doi.org/10.1515/znc-1999-1120.

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Abstract Live Trypanosoma cruzi amastigotes hydrolyzed p-nitrophenylphosphate (PNPP), phos-pho-amino-acids and 32P-casein under physiologically appropriate conditions. PNPP was hydrolysed at a rate of 80 nmol ·mg -1 ·h -1 in the presence of 5 mм MgCl2, pH 7.2 at 30 °C. In the absence of Mg2+ the activity was reduced 40% and we call this basal activity. At saturating concentration of PNPP, half-maximal PNPP hydrolysis was obtained with 0.22 mм MgCl2· Ca2+ had no effect on the basal activity, could not substitute Mg2+ as an activator and in contrast inhibited the PNPP hydrolysis stimulated by M

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Aldergham, Samar, Abdalmageed Qopori, Raad Bahmaishan, Wessam Tayyar, Sadaga Maghrabi, Rinad Nawab, Majd Eskndrani, and Yazeed Albudair. "Methods and Challenges in Preventive Dental Care of the Elderly." Journal of Healthcare Sciences 02, no. 11 (2022): 354–60. http://dx.doi.org/10.52533/johs.2022.21104.

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As individuals age, physiologic alterations take place in the oral cavity, and are thought to be a regular component of the ageing process. However, pathological developments that are not harmless, and that need professional care, are frequently encountered. The line between physiological ageing and actual pathological changes is not clear in all cases. The wellbeing of the oral cavity can be compromised with the initiation of tooth loss, soft tissue lesions such as oral carcinoma, neglected grossly carious teeth, neglected severe periodontitis, and orofacial neuralgia. For adequate oral healt

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Gandra, Rafael M., Laura N. Silva, Xênia M. Souto, Leandro S. Sangenito, Lucas P. S. Cruz, Lys A. Braga-Silva, Diego S. Gonçalves, Sergio H. Seabra, Marta H. Branquinha, and André L. S. Santos. "The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto." Medical Mycology 57, no. 8 (February 9, 2019): 1024–37. http://dx.doi.org/10.1093/mmy/myz008.

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AbstractCandida parapsilosis sensu stricto (C. parapsilosis) has emerged as the second/third commonest Candida species isolated from hospitals worldwide. Candida spp. possess numerous virulence attributes, including peptidases that play multiple roles in both physiological and pathological events. So, fungal peptidases are valid targets for new drugs development. With this premise in mind, we have evaluated the effect of serine peptidase inhibitors (SPIs) on both cell biology and virulence aspects of C. parapsilosis. First, five different SPIs, phenylmethylsulfonyl fluoride, benzamidine, 4-(2-

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Million, D., P. Zillner, and R. Baumann. "Oxygen pressure-dependent control of carbonic anhydrase synthesis in chick embryonic erythrocytes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 5 (November 1, 1991): R1188—R1196. http://dx.doi.org/10.1152/ajpregu.1991.261.5.r1188.

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During chick embryonic development carbonic anhydrase (CA) expression of erythrocytes is kept at a very low level until the last week of incubation (i.e., up to day 14). We have previously obtained evidence that hypoxia is the physiological stimulus for rapid onset of CA synthesis before hatching. Looking for putative signals we have carried out in vitro incubations of embryonic erythrocytes, screening a large number of hormones and second messengers, which were all ineffective, with the exception of the A1 agonist N6-phenylisopropyladenosine (adenosine had no effect). However, incubation with

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Wang, Xu. "A Multifunctional Flexible Ferroelectric Transistor Sensor Based on Si/Fe-Doped Indium Oxide for Electronic Skin." Journal of Nanomaterials 2022 (August 16, 2022): 1–7. http://dx.doi.org/10.1155/2022/2952589.

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As the sensing basis and data source of the new generation of information technology, sensors play a vital role in today’s information age. The purpose of this work is to construct a flexible ferroelectric field-effect transistor (FeFET) as a prototype for a multifunctional sensor for electronic skin. The FeFET device is fabricated from poly(vinylidene fluoride-dimethylsiloxane) (P(VDF-DMS)) and Si/Fe-doped indium oxide (SFIO). Furthermore, this device is capable of three-in-one sensing. Specifically, it can detect temperature changes from 0°C to 70°C and monitors external forces with a linear

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SVISTUNENKO, Dimitri A., Martyn A. SHARPE, Peter NICHOLLS, Christine BLENKINSOP, Nathan A. DAVIES, Jacqueline DUNNE, Michael T. WILSON, and Chris E. COOPER. "The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study." Biochemical Journal 351, no. 3 (October 24, 2000): 595–605. http://dx.doi.org/10.1042/bj3510595.

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The paramagnetic species in human metHb and horse metmyoglobin (metMb) have been studied at low temperature using EPR spectroscopy. The high-spin (HS) haem signal in aquometMb has a greater rhombic distortion than the HS metHb signal. Nevertheless, the individual line width (g = 6) is smaller in metMb than in metHb, consistent with non-identical signals from the α and β Hb subunits. Three low-spin (LS) haem forms are present in metHb, while metMb has only two. The major LS form in both proteins is the alkaline species (with OH- at the sixth co-ordination position). The minor LS forms are assig

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Abdelrahman, Mutassim M., Ibrahim A. Alhidary, Riyadh S. Aljumaah, and Bernard Faye. "Blood Trace Element Status in Camels: A Review." Animals 12, no. 16 (August 18, 2022): 2116. http://dx.doi.org/10.3390/ani12162116.

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Trace minerals play an important role in animal health and productivity. They are involved also in many physiological activities, and their deficiency causes a variety of pathological problems and metabolic defects, reducing consequently the animal productivity. The demand for animal products in semi-arid areas is rapidly increasing, and the supply is still below the required level, partially due to low animal productivity. Camels (Camelus dromedarius and Camelus bactrianus) are considered one of the main sources of healthy, high-quality meat and milk for human consumption within most of the c

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DiCorleto, P. E., and C. A. de la Motte. "Thrombin causes increased monocytic-cell adhesion to endothelial cells through a protein kinase C-dependent pathway." Biochemical Journal 264, no. 1 (November 15, 1989): 71–77. http://dx.doi.org/10.1042/bj2640071.

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The coagulation protein thrombin has been shown to stimulate multiple endothelial-cell (EC) functions, including production of platelet-derived growth factor and of platelet-activating factor (PAF), and neutrophil adhesion. We have found that thrombin causes increased binding of monocytic cells (U937 cells and normal human monocytes) to cultured EC of various species. Maximum adhesion of monocytes to pig aortic EC occurred 6 h after thrombin treatment and remained elevated through 24 h. Stimulation of adherence by bovine alpha-thrombin was half-maximal at 15 units/ml, and reached a plateau at

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He, L., B. Dinger, K. Sanders, J. Hoidal, A. Obeso, L. Stensaas, S. Fidone, and C. Gonzalez. "Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 289, no. 6 (December 2005): L916—L924. http://dx.doi.org/10.1152/ajplung.00015.2005.

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Membrane potential in oxygen-sensitive type I cells in carotid body is controlled by diverse sets of voltage-dependent and -independent K+ channels. Coupling of Po2 to the open-closed state of channels may involve production of reactive oxygen species (ROS) by NADPH oxidase. One hypothesis suggests that ROS are produced in proportion to the prevailing Po2 and a subset of K+ channels closes as ROS levels decrease. We evaluated ROS levels in normal and p47 phox gene-deleted [NADPH oxidase knockout (KO)] type I cells using the ROS-sensitive dye dihydroethidium (DHE). In normal cells, hypoxia elic

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Rhodes, CG, and JM Hughes. "Pulmonary studies using positron emission tomography." European Respiratory Journal 8, no. 6 (June 1, 1995): 1001–17. http://dx.doi.org/10.1183/09031936.95.08061001.

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The detailed investigation of regional differences in lung function at a local level began when suitable gamma-ray emitting isotopes and focused external radiation detectors (especially the Anger gamma-camera) became available. A major recent advance has been the development of positron emission tomography (PET), which provides a powerful combination of highly accurate tomographic reconstruction of radioisotope concentration with a potentially unlimited list of biological compounds to be labelled with the positron emitting isotopes of oxygen, carbon and fluorine. Early studies using PET focuse

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Furman R.L.*, Barylo O. S. ,. Agafonov K. V. ,. Kirichek O. V. ,. "COMPREHENSIVE STUDY OF ORAL HYGIENE STATUS IN 40-50 YEAR-OLD WOMEN RANGES USING DRUG PRODUCT TO INCREASE RESISTANCE OF DENTAL HARD TISSUES." Innovative Journal of Medical and Health Science 9, no. 3 (March 22, 2019): 343–46. http://dx.doi.org/10.15520/ijmhs.v9i3.2483.

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Resistance of tooth enamel to aggressive effect of metabolic by-products of oral cavity microorganisms is provided by fluoroapatites of enamel surface layers. The patients were divided into two groups: control group (30 females) and experimental (observa-tion) group (30 females). In control group, the traditional method of caries prevention was used, which included professional teeth cleaning, mouthwash with physiological solution (0.9%) of sodium chloride after meals, hygienic teeth brushing by a standard method twice a day. Females of experimental group underwent professional teeth cleaning,

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Isaac, R. E. "Proctolin degradation by membrane peptidases from nervous tissues of the desert locust (Schistocerca gregaria)." Biochemical Journal 245, no. 2 (July 15, 1987): 365–70. http://dx.doi.org/10.1042/bj2450365.

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The hydrolysis of the insect neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) by enzyme preparations from the nervous tissue of the desert locust (Schistocerca gregaria) was investigated. Neural homogenate degraded proctolin (100 microM) at neutral pH by cleavage of the Arg-Tyr and Tyr-Leu bonds to yield Tyr-Leu-Pro-Thr, Arg-Tyr and free tyrosine. Arg-Tyr was detected as a major metabolite when the aminopeptidase inhibitors amastatin and bestatin were present to prevent Arg-Tyr breakdown. Around 50% of the proctolin-degrading activity was isolated in a 30,000 g membrane fraction and was shown to b

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Kumar, Dhiraj, Akhilesh Mishra, Ala Lisok, Rakeeb Kureshi, Sagar Shelake, Donika Plyku, Rupashree Sen, et al. "Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics." Proceedings of the National Academy of Sciences 118, no. 37 (September 10, 2021): e2107982118. http://dx.doi.org/10.1073/pnas.2107982118.

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Macromolecules such as monoclonal antibodies (mAbs) are likely to experience poor tumor penetration because of their large size, and thus low drug exposure of target cells within a tumor could contribute to suboptimal responses. Given the challenge of inadequate quantitative tools to assess mAb activity within tumors, we hypothesized that measurement of accessible target levels in tumors could elucidate the pharmacologic activity of a mAb and could be used to compare the activity of different mAbs. Using positron emission tomography (PET), we measured the pharmacodynamics of immune checkpoint

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