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Journal articles on the topic 'Focal Osteoarthritic Cartilage Lesions'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pattappa, Girish, Jonas Krueckel, Ruth Schewior, et al. "Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model." Biology 9, no. 8 (2020): 230. http://dx.doi.org/10.3390/biology9080230.

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Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects. Mesenchymal stem cells (MSCs) are an alternative cell source for treating early OA defects, due to their greater chondrogenic potential, compared to early OA chondrocytes. Low oxygen tension or physioxia has been shown to enhance MSC chondrogenic matrix content and could improve functional outcomes of regenerative therapies. The present invest

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2

David-Vaudey, E., A. Burghardt, K. Keshari, A. Brouchet, M. Ries, and S. Majumdar. "Fourier transform infrared imaging of focal lesions in Human osteoarthritic cartilage." European Cells and Materials 10 (November 22, 2005): 51–60. http://dx.doi.org/10.22203/ecm.v010a06.

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Lee, Keh-Yang, Timothy C. Dunn, Lynne S. Steinbach, Eugene Ozhinsky, Michael D. Ries, and Sharmila Majumdar. "Computer-aided quantification of focal cartilage lesions of osteoarthritic knee using MRI." Magnetic Resonance Imaging 22, no. 8 (2004): 1105–15. http://dx.doi.org/10.1016/j.mri.2004.01.076.

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Rehnitz, Christoph, Marc-André Weber, and Felix Wuennemann. "Imaging of the Knee Following Repair of Focal Articular Cartilage Lesions." Seminars in Musculoskeletal Radiology 22, no. 04 (2018): 377–85. http://dx.doi.org/10.1055/s-0038-1667301.

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AbstractFocal chondral or osteochondral lesions of the knee are common lesions involving either the cartilage layers or the cartilage layers and the subchondral bone. Despite their heterogeneous clinical presentation, they are important risk factors for the premature development of osteoarthritis. Therefore, early detection of osteochondral lesions and focal cartilage defects is crucial. In symptomatic (osteo-)chondral lesions, numerous therapeutic strategies, ranging from conservative treatment to surgical procedures such as marrow stimulation, osteochondral autograft transplantation, or auto

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Accadbled, Franck, Marco Turati, and Mininder S. Kocher. "Osteochondritis dissecans of the knee: Imaging, instability concept, and criteria." Journal of Children's Orthopaedics 17, no. 1 (2023): 47–53. http://dx.doi.org/10.1177/18632521221149054.

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Osteochondritis dissecans of the knee is an idiopathic, focal, subchondral-bone abnormality that can cause instability or detachment of a bone fragment and overlying articular cartilage, with subsequent progression to osteoarthritis. The degree of lesion instability is best assessed by magnetic resonance imaging. Unstable lesions require operative management with fragment fixation. Level of evidence: V.

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Springer, Bernhard, and Friedrich Boettner. "Treatment of Unicompartmental Cartilage Defects of the Knee with Unicompartmental Knee Arthroplasty, Patellofemoral Partial Knee Arthroplasty or Focal Resurfacing." Life 11, no. 5 (2021): 394. http://dx.doi.org/10.3390/life11050394.

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Focal chondral defects are common lesions of the articular cartilage. They are predominantly found on the medial femoral condyle and often progress to osteoarthritis of the knee. Various conservative treatment options are available. The conservative treatment might reduce pain and delay the progress of degenerative processes. However, restoration of the articular cartilage cannot be accomplished. If the conservative treatment fails unicompartmental arthroplasty, patellofemoral joint replacement or focal resurfacing are reasonable options to postpone total knee arthroplasty. A careful patient s

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Guillén-García, Pedro, Isabel Guillén-Vicente, Elena Rodríguez-Iñigo, et al. "Cartilage Defect Treatment Using High-Density Autologous Chondrocyte Implantation (HD-ACI)." Bioengineering 10, no. 9 (2023): 1083. http://dx.doi.org/10.3390/bioengineering10091083.

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Hyaline cartilage’s inability to self-repair can lead to osteoarthritis and joint replacement. Various treatments, including cell therapy, have been developed for cartilage damage. Autologous chondrocyte implantation (ACI) is considered the best option for focal chondral lesions. In this article, we aimed to create a narrative review that highlights the evolution and enhancement of our chondrocyte implantation technique: High-Density-ACI (HD-ACI) Membrane-assisted Autologous Chondrocyte Implantation (MACI) improved ACI using a collagen membrane as a carrier. However, low cell density in MACI r

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Longo, Umile Giuseppe, Stefano Petrillo, Edoardo Franceschetti, Alessandra Berton, Nicola Maffulli, and Vincenzo Denaro. "Stem Cells and Gene Therapy for Cartilage Repair." Stem Cells International 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/168385.

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Cartilage defects represent a common problem in orthopaedic practice. Predisposing factors include traumas, inflammatory conditions, and biomechanics alterations. Conservative management of cartilage defects often fails, and patients with this lesions may need surgical intervention. Several treatment strategies have been proposed, although only surgery has been proved to be predictably effective. Usually, in focal cartilage defects without a stable fibrocartilaginous repair tissue formed, surgeons try to promote a natural fibrocartilaginous response by using marrow stimulating techniques, such

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Shim, Dong-Woo, Yeokgu Hwang, Yoo Jung Park, Jin Woo Lee, and Seung Hwan Han. "Detection of Tram Track Lesion in the Ankle Joint; A Comparative Study of Magnetic Resonance Imaging with Ankle Arthroscopy." Foot & Ankle Orthopaedics 2, no. 3 (2017): 2473011417S0003. http://dx.doi.org/10.1177/2473011417s000371.

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Category: Ankle, Arthroscopy Introduction/Purpose: Tram track lesion in the ankle joint has been occasionally found during the ankle arthroscopy and there has been few studies relating the pathophysiology, diagnostic method and treatment of the lesion. This study aimed to show the effectiveness of magnetic resonance imaging (MRI) for detection of tram track lesion in the ankle joint comparing with ankle arthroscopy. Methods: We retrospectively assessed 175 ankles in 170 patients with anterior bony impingement syndrome in the ankle who underwent arthroscopic surgery between January 2013 and Jul

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Rodríguez-Fontán, Francisco, and Cecilia Pascual-Garrido. "Hidrogeles de polimerización in situ para la regeneración de cartílago articular. [In-situ-forming hydrogels for articular cartilage repair]." Revista de la Asociación Argentina de Ortopedia y Traumatología 84, no. 3 (2019): 296–308. http://dx.doi.org/10.15417/issn.1852-7434.2019.84.3.956.

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Una significativa cantidad de adultos jóvenes activos sufre lesiones condrales focales. Estas lesiones, si no se tratan, pueden progresar hacia la artrosis, que es una de las principales enfermedades musculoesqueléticas debilitantes y de gran carga económica que afectan a toda sociedad. Pese a los tratamientos quirúrgicos disponibles para la reparación de defectos condrales focales sintomáticos que mejoran la calidad de vida a mediano plazo, hay un mayor riesgo de progresión hacia la artrosis prematura. Los tratamientos biológicos (células madre, bioingeniería tisular) han avanzado a grandes p

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Trattnig, S., C. Scotti, D. Laurent, et al. "POS0277 ANABOLIC EFFECT OF LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 363.2–363. http://dx.doi.org/10.1136/annrheumdis-2021-eular.447.

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Background:LNA043 is a modified, recombinant version of the human angiopoietin-like 3 (ANGPTL3) protein acting directly on cartilage-resident cells to transmit its cartilage anabolic effect. A first-in-human study previously demonstrated the favourable safety profile and the modulation of several pathways involved in cartilage homeostasis and osteoarthritis (OA)1. A previous proof-of-mechanism imaging study used high field (7 Tesla) magnetic resonance imaging (MRI) to show formation of hyaline-like tissue after a single injection of 20 mg LNA043 (unpublished data).Objectives:To evaluate non-in

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Ulstein, Svend, Asbjorn Aroen, Magnus L. Forssblad, Lars Engebretsen, and Jan Harald Røtterud. "Effect of Concomitant Cartilage Lesions on Patient-Reported Outcome After ACL-Reconstruction-A Nationwide Cohort Study from Norway and Sweden of 8470 Patients With 5-Year Follow-Up." Orthopaedic Journal of Sports Medicine 6, no. 7_suppl4 (2018): 2325967118S0005. http://dx.doi.org/10.1177/2325967118s00058.

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Objectives: To evaluate (1) the effect of concomitant partial-thickness (International Cartilage Repair Society [ICRS] grades 1-2) and full-thickness (ICRS grades 3-4) cartilage lesions on patient-reported outcome 5 years after Anterior Cruciate Ligament Reconstruction (ACLR), and (2) the effect of debridement or microfracture (MF) compared with no treatment of concomitant full-thickness cartilage lesions on patient-reported outcome 5 years after ACLR. Methods: All patients that underwent unilateral primary ACLR registered in the Norwegian and Swedish National Knee Ligament Registries from 200

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Wasim Anwar, Zeeshan Aziz, Noor Rahman, Sabir Khan Khattak, Israr Ahmad, and Azhar Hayat Khan. "Arthroscopic evaluation of articular cartilage in knee injuries: A predictor of early osteoarthritis in young population." Professional Medical Journal 30, no. 05 (2023): 654–58. http://dx.doi.org/10.29309/tpmj/2023.30.05.7322.

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Objective: To evaluate articular Cartilage after Knee injuries in young population as predictor of early Osteoarthritis, to pave the much more effective OA preventive measures in young population. Study Design: Descriptive Case Series. Setting: Department of Orthopedics, Hayatabad Medical Complex, Peshawar. Period: 2020 to 2021. Material & Methods: One hundred forty five patients was conducted in Early Osteoarthritis was defined as a diffuse and ill-defined involvement, but originated in the cartilage surrounding a focal lesion, considered to include a maximal involvement of 50% of the car

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Heinz, Tizian, Stephan Reppenhagen, Mike Wagenbrenner, et al. "Focal cartilage defects of the lateral compartment do influence the outcome after high tibial valgus osteotomy." SICOT-J 7 (2021): 44. http://dx.doi.org/10.1051/sicotj/2021044.

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Introduction: High tibial medial open-wedge valgus osteotomy (HTO) is a well-established procedure for unicompartimental medial osteoarthritis of the young and active patient. However, the influence of cartilage defects of the lateral compartment on the total outcome remains obscure. Methods: From 2005 to 2012, a total of 63 patients underwent HTO for medial osteoarthritis of the knee at a single university orthopaedic center. Baseline data as well as intraoperative findings, including the grade and location of cartilage lesions, were evaluated retrospectively. Two groups were formed regarding

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Anderson, Devon E., Michael B. Rose, Aaron J. Wille, Jack Wiedrick, and Dennis C. Crawford. "Arthroscopic Mechanical Chondroplasty of the Knee Is Beneficial for Treatment of Focal Cartilage Lesions in the Absence of Concurrent Pathology." Orthopaedic Journal of Sports Medicine 5, no. 5 (2017): 232596711770721. http://dx.doi.org/10.1177/2325967117707213.

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Background: Articular cartilage lacks the ability for intrinsic repair after acute injury, and focal articular cartilage lesions cause significant morbidity worldwide. Arthroscopic debridement (chondroplasty) represents the majority of cartilage procedures of the knee; however, limited data exist regarding outcomes after chondroplasty performed in isolation of concurrent procedures or not as a primary treatment for osteoarthritis (OA). Hypothesis: Arthroscopic mechanical chondroplasty is beneficial for patients with a focal cartilage lesion of the knee in the absence of meniscal pathology or O

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Pattappa, Girish, Brian Johnstone, Johannes Zellner, Denitsa Docheva, and Peter Angele. "The Importance of Physioxia in Mesenchymal Stem Cell Chondrogenesis and the Mechanisms Controlling Its Response." International Journal of Molecular Sciences 20, no. 3 (2019): 484. http://dx.doi.org/10.3390/ijms20030484.

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Articular cartilage covers the surface of synovial joints and enables joint movement. However, it is susceptible to progressive degeneration with age that can be accelerated by either previous joint injury or meniscectomy. This degenerative disease is known as osteoarthritis (OA) and it greatly affects the adult population. Cell-based tissue engineering provides a possible solution for treating OA at its earliest stages, particularly focal cartilage lesions. A candidate cell type for treating these focal defects are Mesenchymal Stem Cells (MSCs). However, present methods for differentiating th

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Matthews, John R., Joseph M. Brutico, Daniel T. Abraham, et al. "Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects." Orthopaedic Journal of Sports Medicine 10, no. 2 (2022): 232596712110584. http://dx.doi.org/10.1177/23259671211058425.

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Background: Articular cartilage pathology can result from a spectrum of origins, including trauma, osteochondritis dissecans, avascular necrosis, or degenerative joint disease. Purpose: To compare the differences in clinical and patient-reported outcomes after autologous chondrocyte implantation (ACI) versus osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective review identified patients who underwent ACI or OCA between 2008 and 2016 for isolated g

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Bothe, Friederike, Anne-Kathrin Deubel, Eliane Hesse, et al. "Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs." International Journal of Molecular Sciences 20, no. 3 (2019): 653. http://dx.doi.org/10.3390/ijms20030653.

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Despite advances in cartilage repair strategies, treatment of focal chondral lesions remains an important challenge to prevent osteoarthritis. Articular cartilage is organized into several layers and lack of zonal organization of current grafts is held responsible for insufficient biomechanical and biochemical quality of repair-tissue. The aim was to develop a zonal approach for cartilage regeneration to determine whether the outcome can be improved compared to a non-zonal strategy. Hydrogel-filled polycaprolactone (PCL)-constructs with a chondrocyte-seeded upper-layer deemed to induce hyaline

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Heiss, Dr med Rafael, Ali Guermazi, Prof Dr med Rolf Janka, et al. "Update: Posttreatment Imaging of the Knee after Cartilage Repair." Seminars in Musculoskeletal Radiology 26, no. 03 (2022): 216–29. http://dx.doi.org/10.1055/s-0042-1743405.

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AbstractFocal cartilage lesions are common pathologies at the knee joint that are considered important risk factors for the premature development of osteoarthritis. A wide range of surgical options, including but not limited to marrow stimulation, osteochondral auto- and allografting, and autologous chondrocyte implantation, allows for targeted treatment of focal cartilage defects. Arthroscopy is the standard of reference for the assessment of cartilage integrity and quality before and after repair. However, deep cartilage layers, intrachondral composition, and the subchondral bone are only pa

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Messaoudi, Océane, Christel Henrionnet, Kevin Bourge, Damien Loeuille, Pierre Gillet, and Astrid Pinzano. "Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering." Cells 10, no. 1 (2020): 2. http://dx.doi.org/10.3390/cells10010002.

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Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis. Cartilage tissue engineering represents a promising alternative to the current insufficient surgical solutions. 3D printing is a thriving technology and offers new possibilities for personalized regenerative medicine. Extrusion-based processes permit the deposition of cell-seeded bioinks, in a layer-by-layer manner, allowing mimicry of the native zonal organization of hyaline cartilage. Mese

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Verron, Romain, Lucie Zhang, Hélène Bisseriex, et al. "SAS-PRP Study: A Real-Life Satisfaction Assessment in Patients with Cartilage Lesions of the Knee Treated by Platelet-Rich Plasma." Bioengineering 10, no. 11 (2023): 1276. http://dx.doi.org/10.3390/bioengineering10111276.

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Platelet-rich plasma (PRP) is a rising therapy treating locomotor system lesions such as knee osteoarthritis. The objective of this study was to evaluate patients’ satisfaction 6 to 12 months after a PRP injection for cartilage lesions of their knee under real-life conditions. Patients’ satisfaction was assessed by a specific questionnaire named SATMED-Q©, which explores six different dimensions of a given treatment. In addition, pain and function were assessed thanks to VAS pain, WOMAC, and IKDC scores. Responders were identified through the OMERACT-OARSI criteria. We observed excellent satis

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Tabet, Samuel K., Kelly A. Kimmerling, Galen J. Hale, Natalie R. Munson, and Katie C. Mowry. "Hypothermically Stored Amniotic Membrane for the Treatment of Cartilage Lesions: A Single-Arm Prospective Study with 2-Year Follow-Up." CARTILAGE 13, no. 1 (2022): 194760352110722. http://dx.doi.org/10.1177/19476035211072213.

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Objective The purpose of this study was to determine the safety and efficacy of hypothermically stored amniotic membrane (HSAM) for the treatment of cartilage lesions of the knee using imaging, patient-reported outcomes (PROs), second-look arthroscopy, and histology. Patients were treated with HSAM and followed for 2 years. Design Subjects with focal chondral lesions of the femur (International Cartilage Repair Society grade 3-4) were enrolled in this single-arm prospective study. Standard of care imaging was completed. PROs, including the Knee Injury and Osteoarthritis Outcome Score (KOOS), M

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Bendele, A. M. "Progressive Chronic Osteoarthritis in Femorotibial Joints of Partial Medial Meniscectomized Guinea Pigs." Veterinary Pathology 24, no. 5 (1987): 444–48. http://dx.doi.org/10.1177/030098588702400512.

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The sequential histopathologic alterations in femorotibial joints of partial meniscectomized male and female guinea pigs were evaluated at 1, 2, 3, 6, and 12 weeks post-surgery. Foci of moderate to severe cartilage degeneration were present in the medial tibial plateau and femoral condyle of the operated leg by 1 week post-surgery. At 2 weeks post-surgery, the cartilage degeneration in the operated legs was more extensive and there was evidence of early chondrophyte formation on the medial side of either the femur or tibia in three animals. Changes were progressively more severe at 3, 6, and 1

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de Girolamo, Laura, Herbert Schönhuber, Marco Viganò, et al. "Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study." Journal of Clinical Medicine 8, no. 3 (2019): 392. http://dx.doi.org/10.3390/jcm8030392.

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The aims of the study were to evaluate long-term outcomes after autologous matrix-induced chondrogenesis (AMIC) in the treatment of focal chondral lesions and to assess the possible improvements given by the combination of this technique with bone marrow aspirate concentrate (BMAC). Twenty-four patients (age range 18–55 years) affected by focal knee chondral lesions were treated with standard AMIC or AMIC enhanced by BMAC (AMIC+). Pain (Visual Analogue Scale (VAS)) and functional scores (Lysholm, International Knee Documentation Committee (IKDC), Tegner, Knee injury and Osteoarthritis Outcome

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Stannard, James P., James T. Stannard, and Anna J. Schreiner. "Fresh Osteochondral Allograft Transplants in the Knee: Bipolar and Beyond." Journal of Knee Surgery 33, no. 12 (2020): 1172–79. http://dx.doi.org/10.1055/s-0040-1714366.

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AbstractKnee patients who have sustained chondral and osteochondral lesions suffer from debilitating pain, which can ultimately lead to posttraumatic osteoarthritis and whole-joint disease. Older, nonactive patients are traditionally steered toward total knee arthroplasty (TKA), but younger, active patients are not good candidates for TKA based on implant longevity, complications, morbidity, and risk for revision, such that treatment strategies at restoring missing hyaline cartilage and bone are highly desired for this patient population. Over the past four decades, fresh osteochondral allogra

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Weber, Christian D., Filippo Migliorini, and Frank Hildebrand. "Reconstruction of Large Osteochondral Lesions in the Knee: Focus on Fixation Techniques." Life 11, no. 6 (2021): 543. http://dx.doi.org/10.3390/life11060543.

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Large (>3 cm2), focal osteochondral lesions (OCL) may result in poor functional outcomes and early secondary osteoarthritis of the knee. The surgical management of these OCL remains challenging. The treatment strategy must be tailored to various aspects, including lesion-specific (e.g., size, location, chronicity), joint-specific (e.g., instability, limb alignment, meniscal status), and patient-specific factors (e.g., age, activity level, comorbidities). Simple chondroplasty and bone marrow stimulation (BMS) techniques should be reserved for smaller lesions, as they only realize midterm cli

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Weiden, G. V. D., N. V. Egmond, M. Karperien, et al. "SAFETY AND PERFORMANCE OF DEXTRAN-TYRAMINE HYDROGEL IMPLANT FOR FOCAL ARTICULAR CARTILAGE LESIONS OF THE KNEE (ACTIVE): PRELIMINARY DATA OF THE SAFETY COHORT." Orthopaedic Proceedings 106-B, SUPP_18 (2024): 109. http://dx.doi.org/10.1302/1358-992x.2024.18.109.

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IntroductionThe ACTIVE(Advanced Cartilage Treatment with Injectable-hydrogel Validation of the Effect) study investigates safety and performance of a novel dextran-tyramine hydrogel implant for treatment of small cartilage defects in the knee (0.5-2.0cm2). The hydrogel is composed of a mixture of natural polymer conjugates that are mixed intra-operatively and which cross-link in situ through a mild enzymatic reaction, providing a cell-free scaffold for cartilage repair.MethodThe ACTIVE study is split into a safety (n=10) and a performance cohort (n=36). The Knee Injury and Osteoarthritis Outco

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Bekkers, J. E. J., Th S. de Windt, N. J. H. Raijmakers, W. J. A. Dhert, and D. B. F. Saris. "Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions." Osteoarthritis and Cartilage 17, no. 11 (2009): 1434–39. http://dx.doi.org/10.1016/j.joca.2009.04.019.

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Valot, Laurine, Marie Maumus, Luc Brunel, et al. "A Collagen-Mimetic Organic-Inorganic Hydrogel for Cartilage Engineering." Gels 7, no. 2 (2021): 73. http://dx.doi.org/10.3390/gels7020073.

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Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the injured joint. Preclinical and clinical data using MSCs embedded in a collagen gel have demonstrated improvements in patients with focal lesions and osteoarthritis. However, an improvement is often observed in the short or medium term due to the loss of the chondrocyte capacity to produce the correct extracellular matrix and to respond to mechanical stimulation. Developing novel biomimetic materials with better chondroconductive and mecha

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Dhillon, Jaydeep, Matthew J. Kraeutler, Sydney M. Fasulo, John W. Belk, Anthony J. Scillia, and Patrick C. McCulloch. "Isolated Osteotomy Versus Combined Osteotomy and Cartilage Repair for Osteoarthritis or Focal Chondral Defects of the Medial Compartment of the Knee Joint: A Systematic Review." Orthopaedic Journal of Sports Medicine 11, no. 5 (2023): 232596712311620. http://dx.doi.org/10.1177/23259671231162030.

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Background: The extent to which concomitant cartilage repair provides an improvement in clinical outcomes after osteotomy is unclear. Purpose: To compare studies reporting clinical outcomes after isolated osteotomy with or without cartilage repair for osteoarthritis (OA) or focal chondral defects (FCDs) of the knee joint. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines by searching PubMed, Cochrane Library, and Embase databases. The search wa

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Song, Jun-Seob, Ki-Taek Hong, Na-Min Kim, et al. "Clinical and Magnetic Resonance Imaging Outcomes After Human Cord Blood–Derived Mesenchymal Stem Cell Implantation for Chondral Defects of the Knee." Orthopaedic Journal of Sports Medicine 11, no. 4 (2023): 232596712311583. http://dx.doi.org/10.1177/23259671231158391.

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Background: There is a paucity of literature reporting clinical and magnetic resonance imaging (MRI) outcomes after allogeneic umbilical cord blood–derived mesenchymal stem cell (UCB-MSC) implantation for chondral defects of the knee. Purpose: To report clinical and MRI outcomes after UCB-MSC implantation for chondral lesions of the knee. Study Design: Case series; Level of evidence, 4. Methods: Inclusion criteria were patients aged between 40 and 70 years with focal chondral lesions of grade 3 or 4 on the medial femoral condyle, defect sizes >4 cm2, and intact ligaments. Exclusion criteria

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Delco, Michelle L., Margaret Goodale, Jan F. Talts та ін. "Integrin α10β1-Selected Mesenchymal Stem Cells Mitigate the Progression of Osteoarthritis in an Equine Talar Impact Model". American Journal of Sports Medicine 48, № 3 (2020): 612–23. http://dx.doi.org/10.1177/0363546519899087.

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Background: Early intervention with mesenchymal stem cells (MSCs) after articular trauma has the potential to limit progression of focal lesions and prevent ongoing cartilage degeneration by modulating the joint environment and/or contributing to repair. Integrin α10β1 is the main collagen type II binding receptor on chondrocytes, and MSCs that are selected for high expression of the α10 subunit have improved chondrogenic potential. The ability of α10β1-selected (integrin α10high) MSCs to protect cartilage after injury has not been investigated. Purpose: To investigate integrin α10high MSCs to

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Ahedi, Harbeer G., Dawn A. Aitken, Leigh C. Blizzard, Chang-hai H. Ding, Flavia M. Cicuttini, and Graeme Jones. "Correlates of Hip Cartilage Defects: A Cross-sectional Study in Older Adults." Journal of Rheumatology 43, no. 7 (2016): 1406–12. http://dx.doi.org/10.3899/jrheum.151001.

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Objective.Knee cartilage defects are a key feature of osteoarthritis (OA) but correlates of hip defects remain unexplored. The aims of this cross-sectional study were to describe the correlates of hip cartilage defects.Methods.The study included 194 subjects from the Tasmanian Older Adult Cohort who had right hip short-tau inversion recovery magnetic resonance imaging (MRI). Hip cartilage defects were assessed and categorized as grade 0 = no defects, grade 1 = focal blistering or irregularities on cartilage or partial thickness defect, and grade 2 = full thickness defect. Hip pain was determin

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Schmal, Hagen, Ingo H. Pilz, Alexander T. Mehlhorn, et al. "Expression of BMP-receptor type 1A correlates with progress of osteoarthritis in human knee joints with focal cartilage lesions." Cytotherapy 14, no. 7 (2012): 868–76. http://dx.doi.org/10.3109/14653249.2012.681039.

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Bode, Lisa, Anna-Sophie Brenner, Helge Eberbach, et al. "Ten year results following HTO - analysis of clinical outcome and survival rates in terms of TKA revision." Orthopaedic Journal of Sports Medicine 8, no. 9_suppl7 (2020): 2325967120S0051. http://dx.doi.org/10.1177/2325967120s00518.

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Introduction: Varus deformity is a well-known risk factor for focal cartilage defects and even medial osteoarthritis of the knee due to increase of medial compartment peak pressure. High tibial osteotomy using angular-stable implants is an effective and standardized method unloading the medial compartment and resulting in pain reduction and excellent clinical follow-up. Until now only mid-term results have been published and little is known concerning conversion to total knee arthroplasty (TKA). Purpose of the present study is to examine long-term results with special focus on TKA convesion. H

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Kraeutler, Matthew J., John W. Belk, Justin M. Purcell, and Eric C. McCarty. "Microfracture Versus Autologous Chondrocyte Implantation for Articular Cartilage Lesions in the Knee: A Systematic Review of 5-Year Outcomes." American Journal of Sports Medicine 46, no. 4 (2017): 995–99. http://dx.doi.org/10.1177/0363546517701912.

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Background: Microfracture (MFx) and autologous chondrocyte implantation (ACI) are 2 surgical treatment options used to treat articular cartilage injuries of the knee joint. Purpose: To compare the midterm to long-term clinical outcomes of MFx versus ACI for focal chondral defects of the knee. Study Design: Systematic review. Methods: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to locate studies (level of evidence I-III) comparing the minimum average 5-year clinical outcomes of patients undergoing MFx versus ACI. Search terms used were “knee,” “microf

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Jarraya, M., F. Roemer, E. Ashbeck, J. Lynch, C. K. Kwoh, and A. Guermazi. "POS0177 HETEROGENOUS CARTILAGE DAMAGE SEEN ON MRI AMONG KNEES WITH KELLGREN-LAWRENCE 2 & 3 OSTEOARTHRITIS: WHAT ARE THE IMPLICATIONS FOR CLINICAL TRIALS?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 319–20. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1882.

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BackgroundThe most recent update of the Global Burden of Disease figures (GBD 2013) estimated that 242 million people were living in the world with symptomatic and activity-limiting OA of the hip and/or knee. Many potential disease-modifying osteoarthritis drugs (DMOADs) have been investigated, but to date no DMOADs that slow or stop disease progression have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA). A potential reason for the lack of demonstrated efficacy may be reliance on radiographs for defining structural inclusion and exclusion criteri

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Niemeyer, P., M. Hanus, J. Belickas, et al. "Treatment of Large Cartilage Defects in the Knee by Hydrogel-Based Autologous Chondrocyte Implantation: Two-Year Results of a Prospective, Multicenter, Single-Arm Phase III Trial." CARTILAGE 13, no. 1 (2022): 194760352210851. http://dx.doi.org/10.1177/19476035221085146.

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Objective To evaluate the clinical outcome of a hydrogel-based autologous chondrocyte implantation (ACI) for large articular cartilage defects in the knee joint. Design Prospective, multicenter, single-arm, phase III clinical trial. ACI was performed in 100 patients with focal full-thickness cartilage defects ranging from 4 to 12 cm2 in size. The primary outcome measure was the responder rate at 2 years using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Results Two years after ACI treatment, 93% of patients were KOOS responders having improved by ≥10 points compared with their pre-

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Koh, Jason L., Kevin C. Jacob, Rohan Kulkarni, Zachary Vasilion, and Farid M. L. Amirouche. "Consequences of Progressive Full-Thickness Focal Chondral Defects Involving the Medial and Lateral Femoral Condyles After Meniscectomy: A Biomechanical Study Using a Goat Model." Orthopaedic Journal of Sports Medicine 10, no. 3 (2022): 232596712210785. http://dx.doi.org/10.1177/23259671221078598.

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Background: Full-thickness chondral defects alter tibiofemoral joint homeostasis and, if left untreated, have the potential to progress to osteoarthritis. Purpose: To assess the effects of isolated and dual full-thickness chondral defect size and location on the biomechanical properties of the lateral femoral condyle (LFC) and medial femoral condyle (MFC) during dynamic knee flexion in goat knees without menisci. Methods: In 12 goat knees, we created progressively increasing full-thickness circular chondral defects (3-, 5-, and 7.5-mm diameter) in the weightbearing contact area of flexion and

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Khan, Moinuddin Hossain, Sohely Rahman, Md Shahadat Hossain, et al. "Role of Transcutaneous Electrical Nerve Stimulation (Tens) in Management of Pain in Osteoarthritis (OA) of Knee." Journal of Dhaka Medical College 27, no. 1 (2018): 62–67. http://dx.doi.org/10.3329/jdmc.v27i1.38948.

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Context: Osteoarthritis is primarily a disease of cartilage as it is characterized by the degradation of hyaline cartilage in the joints. It is believed to be a dynamic disease that reflects the balance between destruction and repair. Clinically, there is pain, swelling of joints and limitation of motion. Pathological disease is characterized by focal erosive lesions, cartilage destruction, subchondral sclerosis, cyst formation and large osteophyte at the margin of the joints. The objectives of management of osteoarthritis (OA) of the knee are to relieve pain, maintain or improve mobility, and

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Anderson, Devon E., Katlyn S. Robinson, Jack Wiedrick, and Dennis C. Crawford. "Efficacy of Fresh Osteochondral Allograft Transplantation in the Knee for Adults 40 Years and Older." Orthopaedic Journal of Sports Medicine 6, no. 11 (2018): 232596711880544. http://dx.doi.org/10.1177/2325967118805441.

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Background: Osteochondral allograft (OCA) transplantation has become a standard therapy for cartilage restoration in young patients. Purpose: To determine the efficacy of fresh OCA transplantation for focal cartilage lesions in patients aged ≥40 years compared with a group of patients aged ≤39 years. Study Design: Cohort study; Level of evidence, 3. Methods: A database was used to identify patients who underwent fresh OCA transplantation in the knee in a single-surgeon practice over a 10-year period and who completed baseline patient-reported outcome (PRO) questionnaires, including the Interna

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Huang, Sharon G., Liang Zhou, K. John Wagner, Shawn Gee, Philip L. Wilson, and Henry B. Ellis. "LATERAL FEMORAL CONDYLE OSTEOCHONDRITIS DISSECANS: DOES WEIGHTBEARING ZONE LOCATION PREDICT HEALING?" Orthopaedic Journal of Sports Medicine 8, no. 4_suppl3 (2020): 2325967120S0025. http://dx.doi.org/10.1177/2325967120s00257.

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Background: Osteochondritis dissecans (OCD) is a focal, idiopathic alteration of subchondral bone with potential for instability and disruption of adjacent articular cartilage that may result in premature (early secondary) osteoarthritis. Purpose: The purpose of this study was to evaluate differences in clinical, radiographic, and treatment outcomes in weightbearing (WB) versus non-weightbearing (NWB) lateral femoral condyle (LFC) OCDs. Methods: An IRB-approved retrospective review of 62 patients with LFC OCD lesions, 26 of which were weightbearing and 36 non-weightbearing (defined as Cahill a

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Gille, Justus, Ellen Reiss, Moritz Freitag, et al. "Autologous Matrix-Induced Chondrogenesis for Treatment of Focal Cartilage Defects in the Knee: A Follow-up Study." Orthopaedic Journal of Sports Medicine 9, no. 2 (2021): 232596712098187. http://dx.doi.org/10.1177/2325967120981872.

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Background: Autologous matrix-induced chondrogenesis (AMIC) is a well-established treatment for full-thickness cartilage defects. Purpose: To evaluate the long-term clinical outcomes of AMIC for the treatment of chondral lesions of the knee. Study Design: Case series; Level of evidence, 4. Methods: A multisite prospective registry recorded demographic data and outcomes for patients who underwent repair of chondral defects. In total, 131 patients were included in the study. Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) score for pain were used for o

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Gaul, Florian, William D. Bugbee, Heinz R. Hoenecke, and Darryl D. D’Lima. "A Review of Commercially Available Point-of-Care Devices to Concentrate Bone Marrow for the Treatment of Osteoarthritis and Focal Cartilage Lesions." CARTILAGE 10, no. 4 (2018): 387–94. http://dx.doi.org/10.1177/1947603518768080.

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Objective Mesenchymal stem cells (MSCs) are a promising cell-based therapy treatment option for several orthopedic indications. Because culture expansion of MSC is time and cost intensive, a bedside concentration of bone marrow (BM) aspirate is used as an alternative. Many commercial systems are available but the available literature and knowledge regarding these systems is limited. We compared different point-of-care devices that concentrate BM (BMC) by focusing on technical features and quality parameters to help surgeons make informed decisions while selecting the appropriate device. Method

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Baum, Thomas, Gabby B. Joseph, Ahilan Arulanandan, et al. "Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: Data from the Osteoarthritis Initiative." Arthritis Care & Research 64, no. 2 (2012): 248–55. http://dx.doi.org/10.1002/acr.20672.

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Kajabi, Abdul Wahed, Stefan Zbyn, Bradley Nelson, et al. "Poster 200: High Prevalence of Abnormal Imaging Findings in Clinically Asymptomatic Siblings Of JOCD Patients On 3T Knee MRI." Orthopaedic Journal of Sports Medicine 10, no. 7_suppl5 (2022): 2325967121S0076. http://dx.doi.org/10.1177/2325967121s00761.

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Objectives: Endochondral ossification is a skeletal developmental process in children by which the embryonic cartilaginous model of bones undergoes gradual ossification over time until skeletal maturity is reached. Juvenile Osteochondritis Dissecans (JOCD) is a developmental disease characterized by focal areas of chondronecrosis within the epiphyseal cartilage and subsequent delay of the ossification front. JOCD lesions can become loose bodies and lead to premature Osteoarthritis. The etiology of JOCD is not yet well understood, however, there is mounting evidence of a genetic predisposition.

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Anderson, Devon E., Riley J. Williams, Thomas M. DeBerardino, et al. "Magnetic Resonance Imaging Characterization and Clinical Outcomes After NeoCart Surgical Therapy as a Primary Reparative Treatment for Knee Cartilage Injuries." American Journal of Sports Medicine 45, no. 4 (2017): 875–83. http://dx.doi.org/10.1177/0363546516677255.

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Background: Autologous cartilage tissue implants, including the NeoCart implant, are intended to repair focal articular cartilage lesions. Short-term results from United States Food and Drug Administration (FDA) phase I and phase II clinical trials indicated that the NeoCart implant was safe when surgically applied as a cell-based therapy and efficacious compared with microfracture. Hypothesis: Quantitative magnetic resonance imaging (MRI) analysis would reveal NeoCart tissue maturation through to 60-month follow-up. Study Design: Case series; Level of evidence, 4. Methods: Patients with sympt

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Saxer, F., D. Laurent, C. Scotti, et al. "CARTILAGE REGENERATION AFTER TREATMENT WITH LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS IN THE KNEE." Osteoarthritis and Cartilage 30 (April 2022): S206—S207. http://dx.doi.org/10.1016/j.joca.2022.02.276.

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Dhaliwal, Jagwinder, and Andrew Wines. "Results of Arthroscopic Talar Osteochondral Lesions with Bone Marrow Stimulation and BST-CarGel." Foot & Ankle Orthopaedics 4, no. 4 (2019): 2473011419S0016. http://dx.doi.org/10.1177/2473011419s00163.

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Category: Ankle, Trauma Introduction/Purpose: Osteochondral lesions (OCL) are described as any defect involving both the articular surface and the subchondral bone of the talus. They are commonly associated with acute ankle injuries occurring often in active population. Bone marrow stimulation with microfracture is a standard reparative treatment for OCD however decline in related functional outcome has been reported. BST-CarGel contains chitosan which binds to negatively charged cartilage surface acting as biocompatible scaffold. This allows repair tissue with significant filling volume and p

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Kim, Kyung-Hoon. "Percutaneous Osteoplasty for the Treatment of a Painful Osteochondral Lesion of the Talus: A Case Report and Literature Review." Pain Physician 5;15, no. 5;9 (2012): E743—E748. http://dx.doi.org/10.36076/ppj.2012/15/e743.

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An osteochondral lesion of the talus (OLT) is a lesion involving the talar articular cartilage and its subchondral bone. OLT is a known cause of chronic ankle pain after ankle sprains in the active population. The lesion causes deep ankle pain associated with weight-bearing, impaired function, limited range of motion, stiffness, catching, locking, and swelling. There are 2 common patterns of OLTs. Anterolateral talar dome lesions result from inversion and dorsiflexion injuries of the ankle at the area impacting against the fibula. Posteromedial lesions result from inversion, plantar flexion, a

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