Log in

Relevant bibliographies by topics / Folate receptor / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Folate receptor.

Dissertations / Theses on the topic 'Folate receptor'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Folate receptor.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Chow, Lai-man, and 周勵文. "Folate receptor alpha and reduced folate carrier in endometrialcancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153188.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Tsang, Hiu-may, and 曾嬈媚. "Folate receptor alpha and reduced folate carrier in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4467059X.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Tran, Thuyet Van. "Modulation of Folate Receptor-alpha by Glucocorticoid Receptor and Progesterone Receptor." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1104777244.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Tran, Thuyet Van. "Modulation of folate receptor-[alpha] by glucocorticoid receptor and progesterone receptor." Connect to full-text via OhioLINK ETD Center, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1104777244.

Full text

Abstract:

Thesis (Ph. D.)--Medical College of Ohio, 2004.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Manohar Ratnam. Includes abstract. Document formatted into pages: iii, 293 p. Title from title page of PDF document. Includes bibliographical references (p. 175-281).

APA, Harvard, Vancouver, ISO, and other styles

5

Elnakat, Hala. "Regulation of Folate Receptor Raft Recycling." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1174569209.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Sudimack, Moseley Jennifer Jo. "Targeted drug delivery via the folate receptor /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486459267519529.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Sivakumaran, Suneethi. "Role of Androgen Receptor in Folate Receptor α Regulation and in Prostate Cancer". University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1345570201.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Shatnawi, Aymen Ahmad. "New Mechanisms of Transcriptional Regulation of the Folate Receptor and other genes by steroid Receptors." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1201810595.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Henderson, Elisa Ann. "Folate receptor targeting : approaches to nonpolyglutamatable inhibitors of thymidylate synthase." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428765.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Mishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Andrews, Shannon. "FOLATE CONJUGATED DENDRIMERS FOR TARGETED ANTICANCER THERAPY." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3497.

Full text

Abstract:

Anticancer therapeutics are often limited to suboptimal doses due to their lack of selectivity for tumor cells and resultant damage to healthy tissue. These limitations motivated researchers to develop tumor-specific delivery systems for improved therapeutic efficacy and reduced unintended cytotoxicity. Polyamidoamine dendrimers offer an ideal platform for designing targeted therapeutics with tunable characteristics that optimize pharmacokinetic behavior and targeting specificity. Ligand conjugation to dendrimer provides the biochemical interaction necessary to activate tumor-specific receptor

APA, Harvard, Vancouver, ISO, and other styles

12

Gibbs, David Douglas. "The in vivo development of folate receptor-targeted thymidylate synthase inhibitors." Thesis, Institute of Cancer Research (University Of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407395.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Qi, Huiling. "Modulation of folate receptor B for drug targeting in acute myelogenous leukemia." Connect to full-text via OhioLINK ETD Center, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1147304406.

Full text

Abstract:

Thesis (Ph.D.)--Medical University of Ohio, 2005.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Manohar Ratnam. Includes abstract. Document formatted into pages: iv, 158 p. Title from title page of PDF document. Title at ETD Web site: Modulation of folate receptor beta for drug targeting in acute myelogenous leukemia. Non-Latin script record Bibliography: pages 67-70, 106-109, 127-156.

APA, Harvard, Vancouver, ISO, and other styles

14

Qi, Huiling. "Modulation of Folate Receptor Beta for Drug Targeting in Acute Myelogenous Leukemia." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1147304406.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Bhattacharya, Shiladitya. "Novel folate amphiphile conjugates for targeted drug delivery." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2360.

Full text

Abstract:

Cancer is not only difficult to treat but the patients also suffer from the pain associated with anticancer treatments. Targeted chemotherapeutics can reduce the adverse effects by reducing the dose required for tumor cell kill. Cancers of various origins often have characteristic marker molecules that distinguish them from the normal tissues. Folate receptors are such marker molecules present in ovarian and cervical cancers. The hypothesis for the current study is that amphiphiles constructed out of folic acid, the natural ligand for the folate receptor, can deliver paclitaxel, a chemotherape

APA, Harvard, Vancouver, ISO, and other styles

16

Bahcheli, Daniel Martin. "An examination of the selective targeting of quantum dots via the folate receptor." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18689.

Full text

Abstract:

Semiconductor nanocrystals known as quantum dots (QDs) are emerging as an important new class of fluorescent probes in cell biology due to their many advantageous optical properties. Various methods have devised that allow for the selective targeting of QDs to biological cells. Conjugation of QDs to small biomolecules has proven effective, allowing for their uptake into mammalian cell lines. We explored the use of folate conjugated QDs in the selective targeting of model cell lines known to have high expression of the folate receptor (FR). Characterization of QDs and QD conjugates is examined

APA, Harvard, Vancouver, ISO, and other styles

17

Jaime-Ramirez, Alena Cristina. "HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364465780.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Chiu, Shihjiuan. "Receptor-mediated DNA-based therapeutics delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127403022.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Theti, Davinder Singh. "The development of novel thymidylate synthase inhibitors targeted to a-folate receptor overexpressing tumours." Thesis, Institute of Cancer Research (University Of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430961.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Böttiger, Anna. "Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations." Doctoral thesis, Örebro universitet, Hälsoakademin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2625.

Full text

Abstract:

Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. This thesis focuses on mutations in the genes for folate receptor-alpha and methylenetetrahydrofolate reductase (MTHFR) and the effect they have on tHcy concentrations. Six novel mutations in the gene for folate receptor-alpha were described in Paper I. Take

APA, Harvard, Vancouver, ISO, and other styles

21

Zhao, Xiaobin. "Targeting CD37 and folate receptor for cancer therapy strategies based on engineered protein and liposomes /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174678307.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Schieferstein, Hanno [Verfasser]. "Folic acid derivatives for PET imaging and therapy addressing folate receptor positive tumors / Hanno Schieferstein." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1046352547/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Stevens, Phillip James. "An approach to drug formulation and targeting liposomes and lipid nanoparticles for folate receptor targeting." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111092653.

Full text

Abstract:

Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 110 p.; also includes graphics (some col.) Includes bibliographical references (p. 98-110). Available online via OhioLINK's ETD Center

APA, Harvard, Vancouver, ISO, and other styles

24

Holmes, Lisa. "Development of an ELISA to Detect Folate Receptor alpha (FRα) Autoantibodies, and their Association with Recurrent Miscarriage". Thesis, Holmes, Lisa (2016) Development of an ELISA to Detect Folate Receptor alpha (FRα) Autoantibodies, and their Association with Recurrent Miscarriage. PhD thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/37977/.

Full text

Abstract:

Pregnancy can be a joyous moment in a couple’s life; yet on the other hand it can also bring much heartache to couples that experience any form of pregnancy complication. A significant proportion of pregnancies don’t make full term, in addition, 1% of couples may experience recurrent miscarriage (RM) which can be devastating to the couple (Bansal et al. 2011)…

APA, Harvard, Vancouver, ISO, and other styles

25

Colacino, Katelyn. "The Potential of Cellulose Nanocrystals in the Detection and Treatment of Cancer." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51212.

Full text

Abstract:

Conventional methods of cancer therapy have been severely limited by inefficient delivery of therapeutic doses without incidence of harsh and toxic side effects in normal tissues. Consequently, countless new methods for early detection and drug delivery have been investigated in the area of nanoparticles and hydrogels. Although many of these methods are promising, the complex nature of cancer increases the difficultly for the development of the perfect system.<br />Cellulose nanocrystals (CNCs) have been studied widely for a variety of applications. Despite their advantages, investigations of

APA, Harvard, Vancouver, ISO, and other styles

26

Mislick, Kimberly Ann Baldeschwieler John D. "The role of proteoglycans in the delivery of cationic-DNA complexes and enhanced delivery by folate receptor-mediated endocytosis /." Diss., Pasadena, Calif. : California Institute of Technology, 1996. http://resolver.caltech.edu/CaltechETD:etd-09182006-152253.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Lee, Dian-Jang [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Oligoaminoamide-based siRNA formulations for folate receptor-directed tumor targeting and gene silencing / Dian-Jang Lee ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/112439575X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Esipenko, Nina A. "Design, Synthesis, and Application of Sensors for Biologically Relevant Molecules." Bowling Green State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1395589938.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Dcona, Martin. "Drug Delivery Strategies Using Light Sensitive Molecules." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/445.

Full text

Abstract:

Cancer remains one of the most dreaded diseases due to inevitable suffering and possible fatality. Only cardiac disease has caused more deaths than cancer. Present day cancer treatment involves radiation, surgery or chemotherapy. In chemotherapy, an anti-tumoral drug is used to treat the tumor either by killing or stalling the growth of the tumor cells. In certain types of cancer, for e.g. metastatic breast cancer, the first line of therapy is often chemotherapy. But the inability of current clinically approved drugs to selectively target tumor cells, ultimately results in side effects. To red

APA, Harvard, Vancouver, ISO, and other styles

30

Azaïs, Henri. "Traitement des métastases péritonéales microscopiques des cancers épithéliaux de l'ovaire par thérapie photodynamique ciblée utilisant un adressage par acide folique. Données précliniques." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S014/document.

Full text

Abstract:

Le pronostic des cancers ovariens reste sombre, en particulier en raison du retard diagnostic. Les traitements actuels associent une chirurgie de cytoréduction complète à l'administration de chimiothérapie à base de sels de platine. Les métastases viscérales sont rares dans cette pathologie, et la maladie est longtemps localisée à la cavité péritonéale. Pour cette raison, une attention particulière est portée au traitement des métastases péritonéales. Il est admis en effet que le facteur principal de réduction des récidives est l'absence de résidu tumoral en fin d'intervention. Malgré les prog

APA, Harvard, Vancouver, ISO, and other styles

31

Miranda, Beatriz Nogueira Messias de. "Clonagem, expressão e purificação de alfa receptores de folato de Homo sapiens para aplicações bioanalíticas em câncer." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-29012015-171032/.

Full text

Abstract:

Nos últimos anos a incidência do câncer tem crescido significativamente mundialmente, porém, as técnicas atualmente empregadas para a detecção da doença não são individualmente conclusivas, além de serem extremamente invasivas e não permitirem seu diagnóstico precoce, o que justifica o desenvolvimento de novas tecnologias alternativas para a detecção do câncer. Células cancerígenas possuem receptores específicos de alta afinidade com folato e por serem altamente replicativas, são extremamente dependentes do suprimento de folato reduzido. Os alfa-receptores de folato (FR α) são proteínas

APA, Harvard, Vancouver, ISO, and other styles

32

Rosiere, Rémi. "Development of dry powder formulations for inhalation based on nanomedicine for targeted lung cancer therapy." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/232374/3/TOC.pdf.

Full text

Abstract:

Le cancer du poumon est l’un des cancers les plus fréquents dans le monde et reste le plus meurtrier actuellement en terme d’incidence absolue. Les traitements employés chez les patients atteints d’un cancer du poumon consistent en une combinaison de chirurgie, de radiothérapie et de chimiothérapie. Alors qu’il y a quelques années, les guidelines de traitement étaient principalement basées sur le stade clinique de la maladie, le développement de nouvelles thérapies a mené à une classification plus appropriée des cancers du poumon. Cette nouvelle classification se base, en plus du stade cliniqu

APA, Harvard, Vancouver, ISO, and other styles

33

Rezende, Luciana Montes 1988. "Polimorfismos nos genes ESR1, ESR2 e MTHFR como fatores de risco do câncer de mama esporádico." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312539.

Full text

Abstract:

Orientador: Carmen Sílvia Bertuzzo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-27T06:53:07Z (GMT). No. of bitstreams: 1 Rezende_LucianaMontes_M.pdf: 2160530 bytes, checksum: b9f9b53af213aa35b20cf6a49d746a91 (MD5) Previous issue date: 2015<br>Resumo: O Câncer de Mama (CM) é a forma de neoplasia mais diagnosticada e a principal causa de morte por câncer em várias regiões do mundo, sendo a maior parte CM esporádico. O estilo de vida reprodutivo representa importante fator de risco relacionado à exposição ao

APA, Harvard, Vancouver, ISO, and other styles

34

Péraudeau, Elodie. "Évaluation et optimisation de l'efficacité de conjugués anticancéreux ciblant les récepteurs de l'acide folique." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2309/document.

Full text

Abstract:

En dépit des progrès réalisés ces dernières décennies, le cancer demeure un problème majeur de santé publique. La plupart des chimiothérapies conventionnelles exploitent les propriétés cytotoxiques d'agents non sélectifs qui affectent les cellules à division rapide, qu'elles soient cancéreuses ou non, ce qui peut aboutir à une toxicité importante et de sévères effets secondaires. Pour pallier à ce problème, l'utilisation de ligands de ciblage pour délivrer spécifiquement l'agent cytotoxique aux cellules malignes tout en épargnant les tissus sains est une approche prometteuse. Parmi les différe

APA, Harvard, Vancouver, ISO, and other styles

35

Berrocal, Zaragoza Maria Isabel. "Autoanticossos contra receptors de folat i estat en folats a la població general, durant l'embaràs i efecte sobre la subfertilitat en dones." Doctoral thesis, Universitat Rovira i Virgili, 2009. http://hdl.handle.net/10803/8570.

Full text

Abstract:

Els autoanticossos contra receptors de folat (AuAc-RF), que impedeixen el transport transmembranal de folat per aquesta ruta, s'han associat amb anomalies del desenvolupament neuronal. S'ha investigat les prevalences de portadors d'AuAc-RF i l'estat en folats a la població i a l'embaràs, la causa de la seva producció i l'efecte sobre la subfertilitat femenina.El 7.2% de la població i 6.3% de gestants eren portadors, sense perjudicar l'estat en folats. Peró el folat plasmàtic major dels cordons, indicava presència d'un mecanisme de compensació. Les portadores tenien 4.6 vegades major risc de te

APA, Harvard, Vancouver, ISO, and other styles

36

Peres, Filho Marco Júnio. "Desenvolvimento de lipossomas vetorizados ao receptor folato contendo paclitaxel e imatinibe coencapsulados: avaliação da atividade antiproliferativa e da expressão gênica do VEGF em células tumorais." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7452.

Full text

Abstract:

Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-06-09T20:26:25Z No. of bitstreams: 2 Tese - Marco Júnio Peres Filho - 2014.pdf: 2890867 bytes, checksum: 94c9616394d6a389aadabf3d9a0b128c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-12T12:31:24Z (GMT) No. of bitstreams: 2 Tese - Marco Júnio Peres Filho - 2014.pdf: 2890867 bytes, checksum: 94c9616394d6a389aadabf3d9a0b128c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made availab

APA, Harvard, Vancouver, ISO, and other styles

37

ANCIRA, CORTEZ ALEJANDRA 627063, and CORTEZ ALEJANDRA ANCIRA. "Estudio y caracterización de nanopartículas de óxido de hierro funcionalizadas con Ácido fólico/Rodamina a través de una reacción de entrecruzamiento tipo Carbodiimida." Tesis de maestría, Universidad Autònoma del Estado de Mèxico, 2016. http://hdl.handle.net/20.500.11799/65832.

Full text

Abstract:

De acuerdo a estadísticas que indican que para el año 2012 la incidencia de cáncer a nivel mundial causó 8.2 millones de muertes, esta es considerada como una de las enfermedades con mayor incidencia en mortalidad, siendo los que más defunciones causan los cánceres de pulmón, hígado, estómago y colón. Es por ello que ciencias emergentes como la nanotecnología y las ciencias médicas, suman sus esfuerzos en el diseño de nuevas estrategias para diagnóstico temprano, tratamientos más eficaces y menos efectos indeseables.Las nanopartículas de hierro han sido empleadas como medios de contraste y vec

APA, Harvard, Vancouver, ISO, and other styles

38

Medina, Sánchez Martín. "Polimorfismo de los genes del receptor de folatos reducidos y dihidrofolato reductasa asociados a la farmacocinética y hepatotoxicidad del metrotexato en pacientes pediátricos con leucemia linfoblástica aguda." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/67728.

Full text

Abstract:

La Leucemia Linfoblástica Aguda (LLA) es el tipo de cáncer más frecuente en población pediátrica y una de las principales causas de mortalidad en esta misma (American Cancer Society (ACS). 2014). A pesar de que la sobrevida de los pacientes que presentan LLA ha mejorado con el desarrollo de mejores protocolos de tratamiento (Pui et al., 2011), existen riesgos adicionales que presentan los agentes quimioterapéuticos (Schmiegelow et al., 2014). Un agente quimioterapéutico esencial de todos los protocolos de tratamiento de LLA es el MTX (Pui et al., 2012). A pesar de su eficacia, la variación en

APA, Harvard, Vancouver, ISO, and other styles

39

Micucci, Matteo <1983&gt. "From Folke Medicine to Medicine Chemistry: Study, Using in Vitro and Cellular Assays, of Receptors Mechanism Involved in the Activities of Natural Compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4741/1/Matteo_Micucci_tesi.pdf.

Full text

Abstract:

My Doctorate Research has been focused on the evaluation of the pharmacological activity of a natural extract of chestnut wood (ENC) towards the cardiovascular and gastrointestinal system and on the identification of the active compounds. The ENC has been shown to contain more than 10% (w/w) of phenolic compounds, of which tannins as Vescalgin and Castalgin are the more representative. ENC cardiovascular effects have been investigated in guinea pig cardiac preparations; furthermore its activity has been evalueted in guinea pig aorta strips. ENC induced transient negative chronotropic ef

APA, Harvard, Vancouver, ISO, and other styles

40

Micucci, Matteo <1983&gt. "From Folke Medicine to Medicine Chemistry: Study, Using in Vitro and Cellular Assays, of Receptors Mechanism Involved in the Activities of Natural Compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4741/.

Full text

Abstract:

My Doctorate Research has been focused on the evaluation of the pharmacological activity of a natural extract of chestnut wood (ENC) towards the cardiovascular and gastrointestinal system and on the identification of the active compounds. The ENC has been shown to contain more than 10% (w/w) of phenolic compounds, of which tannins as Vescalgin and Castalgin are the more representative. ENC cardiovascular effects have been investigated in guinea pig cardiac preparations; furthermore its activity has been evalueted in guinea pig aorta strips. ENC induced transient negative chronotropic ef

APA, Harvard, Vancouver, ISO, and other styles

41

Decouvelaere, Stéphanie Françoise. "L'illusoire « meilleure chance » : Le travailleur immigré dans la fiction maghrébine en langue française et dans la fiction caribéenne en langue anglaise, 1948-1979." Thesis, Paris 3, 2009. http://www.theses.fr/2009PA030059/document.

Full text

Abstract:

Cette thèse examine la représentation littéraire de migrations depuis des colonies vers les centres impériaux à l'époque de la décolonisation par l'analyse comparative de romans antillais en langue anglaise et maghrébins en langue française traitant d'immigration vers la Grande-Bretagne et la France respectivement. L'attention portée à la relation de domination est un point de convergence majeur. Lamming, Chraïbi et Kateb la présentent comme une relation coloniale ayant des effets tant économiques que psychologiques et culturels. Boudjedra et Ben Jelloun dans les années 1970 placent et l'immig

APA, Harvard, Vancouver, ISO, and other styles

42

Lin, Han-Wei, and 林漢威. "High Alpha-Folate Receptor Correlates with Poorer Survival in Serous Ovarian Carcinoma." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/26149725544105240508.

Full text

Abstract:

碩士<br>臺灣大學<br>分子醫學研究所<br>98<br>Objectives: To investigate the relationship between alpha-folate receptor (α-FR) expression levels to the clinico-pathologic features and outcomes of patients with serous ovarian carcinoma. Methods: Semi-quantitative reverse-transcription polymerase chain reaction detected α-FR expression in 91 patients with serous ovarian carcinoma. Clinico-pathologic parameters and biomarkers, including FIGO stage, tumor grade, optimal surgery, lymph nodes metastasis, pre-operative serum CA-125, and α-FR expression levels in cancerous tissues to evaluate disease-free interval (

APA, Harvard, Vancouver, ISO, and other styles

43

Guo, Shu-Yu, and 郭書妤. "The Study of Gold Nanorods for Folate Receptor Targeted Photothermal and Photodynamic Therapy." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/48771309298666508012.

Full text

Abstract:

碩士<br>中原大學<br>生物醫學工程研究所<br>103<br>The study was to investigate the application of water-soluble gold nanorods (GNRs) as indocyanine green (ICG) and folic acid (FA) delivering vectors for photodynamic therapy (PDT) and photothermal therapy (PTT) against human epidermoid carcinoma, epithelial growth factor receptor (EGFR) overexpressed A 431 cells and folate receptor (FR) overexpressed KB cells. Ultraviolet-visible spectroscopy, Fourier transformed infrared spectroscopy and fluorescence spectroscopy showed that PEG-ICG and PEG-FA were successfully conjugated to GNRs to prepare GNR-PEG-ICG, GNR-P

APA, Harvard, Vancouver, ISO, and other styles

44

Wang, Yiqiang. "Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies." 2013. http://digital.library.duq.edu/u?/etd,162293.

Full text

Abstract:

This dissertation comprises an introduction, background and current research progress in the area of classical antifolates as the targeted anticancer therapies.<br>In this study, twelve series of classical 5-, 6- and 7-substituted pyrrolo[2,3-d]pyrimidines were designed and synthesized. Extensive structure modifications of the pyrrolo[2,3-d] pyrimidine scaffold were investigated to determine selective transport via FR or/and PCFT and tumor targeted antifolates with GARFTase or multiple folate metabolizing enzyme inhibition.<br>The design strategies employed include: variation of th

APA, Harvard, Vancouver, ISO, and other styles

45

Pragosa, Nancy. "The effects of reduced folate receptor expression on intestinal tumorigenesis in the ApcMin/+ model." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370416&T=F.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Palacios, Ana Maria. "Autoimmune processes in the placentas of neural tube defect-affected pregnancies." 2013. http://hdl.handle.net/2152/22337.

Full text

Abstract:

Neural Tube Defects (NTDs) are a group of common congenital malformations that result from incomplete neural tube closure leading to abnormalities of the brain and/or spinal cord. Unfortunately, their etiology remains unknown, probably due to complex multifactorial interactions. The protective effect of dietary folates in preventing NTDs is well known, but this beneficial effect is limited to the 60 to 70% of cases; leaving 30% of the population without any known option for improving pregnancy outcomes. The mechanism by which folates rescue NTD-affected embryos is poorly understood, but the a

APA, Harvard, Vancouver, ISO, and other styles

47

Just, Isabell Anna. "Charakterisierung neuer Mutationen im FOLR1-Gen." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000E-0101-2.

Full text

Abstract:

In der vorliegenden experimentell durchgeführten Dissertation wurden neue Mutationen im FOLR1-Gen molekular charakterisiert. Die untersuchten Mutationen führten zu Veränderungen im Folatrezeptor α, einem von Zellen des Plexus choroideus exprimierten Protein, welches den Haupttransporter von 5-MTHF über die Blut-Liquor-Schranke darstellt. Mutationen im FOLR1-Gen sind kürzlich als Ursache einer zerebralen Folattransport-Defizienz identifiziert worden. Diese Erkrankung gehört zu einer Gruppe neurologischer Störungen, die sich durch isoliert niedrige Liquorfolatwerte auszeichnen und zusammenfass

APA, Harvard, Vancouver, ISO, and other styles

48

HUang, Chiu-Yi, and 黃久益. "Preparation and characterization of multi-functional caspase-3 loaded nanoparticles for folate receptor and CD44 targeting delivery." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/18994941615758134983.

Full text

Abstract:

碩士<br>萬能科技大學<br>工程科技研究所<br>100<br>Targeted delivery of drugs to cancer cells has attracted considerable attention in developing new chemotherapeutic modalities. In this study, chitosan (CS) and hyaluronan (HA) based nanoparticles with prominent targeting moieties capable of specific interaction with the CD44 and folate receptors (FR) on colon carcinoma HT-29 cells have been developed for Caspase-3 delivery. In the first part of the experiment, crude Caspase-3 protein was purified using hydrophobic HIC column and dialysis apparatus. The purified protein was subsequently indentified by electroph

APA, Harvard, Vancouver, ISO, and other styles

49

Lopes, Ivo Edgar Araújo. "Development of stable lipoplexes DODAC- MO - PEG-FOL for delivery of nucleic acids to cells expressing folate receptor." Master's thesis, 2013. http://hdl.handle.net/1822/25568.

Full text

Abstract:

Dissertação de mestrado em Biofisica e Bionanossistemas<br>With the evolution of cationic liposomes into one of the most appealing and versatile nonviral vectors for the delivery of nucleic acids and the discovery of RNA interference (RNAi), the development of devices to deliver RNAi molecules to specific cells as became an appealing strategy to achieve the treatment of genetic disorders. Hence, with this work we intended to develop and characterize novel systems for therapeutic siRNA delivery based on dioctadecyldimethylammonium chloride (DODAC)/ monoolein (MO) liposomes, which previous

APA, Harvard, Vancouver, ISO, and other styles

50

Huang, Yu-Chin, and 黃有進. "Synthesis and characterization of the superparamagnetic iron oxide nanoparticles surface-modified with poly(ethylene glycol) specifically for folate receptor." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/19075153269557731438.

Full text

Abstract:

碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>93<br>Superparamagnetic iron oxide nanoparticles were surface-modified with poly(ethylene glycol) (PEG) and folic acid, to improve their dispersion and target to specific cells. The success of the synthesis of the SPIO-PEG(400)-FA, SPIO-PEG(1000)-FA and SPIO- PEG(2000)-FA were confirmed by Fourier transform infrared spectroscopy (FT-IR) and UV-Visible spectrophotometer (UV-Vis). On the other hand, TEM analysis showed the well-dispersed nanoparticles after SPIO were coated with PEG and folic acid. The surface-modified with nanoparticles, which were detected by spi

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!