Log in

Relevant bibliographies by topics / Folic acid (FA) / Journal articles

To see the other types of publications on this topic, follow the link: Folic acid (FA).

Journal articles on the topic 'Folic acid (FA)'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Folic acid (FA).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Taira, Junsei, and Takayuki Ogi. "Nitric Oxide Modulation by Folic Acid Fortification." Antioxidants 9, no. 5 (2020): 393. http://dx.doi.org/10.3390/antiox9050393.

Full text

Abstract:

Folic acid (FA) can be protected the neural tube defects (NTDs) causing nitric oxide (NO) induction, but the alleviation mechanism of the detailed FA function against NO has not yet been clarified. This study focused on elucidation of the interaction of FA and NO. FA suppressed nitrite accumulation as the NO indicator in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, then the expression of the iNOS gene due to the LPS treatment was not inhibited by FA, suggesting that FA can modulate against NO or nitrogen radicals. NOR3 (4-ethyl-2-hydroxyamino-5-nitro-3-hexenamide) as the NO donor was us

APA, Harvard, Vancouver, ISO, and other styles

2

Bozack, Anne K., Megan N. Hall, Xinhua Liu, et al. "Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh." American Journal of Clinical Nutrition 109, no. 2 (2018): 380–91. http://dx.doi.org/10.1093/ajcn/nqy148.

Full text

Abstract:

ABSTRACT Background Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced by nutritional factors such as folate and creatine. Objective This study investigated the effects of folic acid (FA) and/or creatine supplementation on the proportion of As metabolites in urine. Design In a 24-wk randomized, double-blinded, placebo-controlled trial, 622 participants were as

APA, Harvard, Vancouver, ISO, and other styles

3

Ranjan, Rahul, Kamla Rawat, and H. B. Bohidar. "Folic acid supramolecular ionogels." Physical Chemistry Chemical Physics 19, no. 34 (2017): 22934–45. http://dx.doi.org/10.1039/c7cp03639f.

Full text

Abstract:

Herein, we report on folic acid (FA, a low molecular weight gelator) thermoreversible supramolecular organo (in 1 : 1 (v/v) water–DMSO binary solvent), and ionogels reported in 1-ethyl-3-methyl imidazolium chloride, [C2mim][Cl], and 1-octyl-3-methyl imidazolium chloride, [C8mim][Cl], solutions with 0.1 ≤ [IL] ≤ 5% (w/v).

APA, Harvard, Vancouver, ISO, and other styles

4

Harper, A. F., M. D. Lindemann, and E. T. Kornegay. "Fetal survival and conceptus development after 42 days of gestation in gilts and sows in response to folic acid supplementation." Canadian Journal of Animal Science 76, no. 1 (1996): 157–60. http://dx.doi.org/10.4141/cjas96-023.

Full text

Abstract:

The effects of feeding 2 ppm supplemental folic acid (FA) on fetal survival and development were assessed in sows (n = 32). Number of live fetuses and fetal survival at day 45 ± 3 of gestation was not influenced by FA. Fetal pig weight, length, protein and RNA content were increased (P < 0.05) with FA treatment, suggesting enhanced development of embryo/fetal tissues with maternal FA supplementation. Key words: Folic acid, gilt, sow, fetal pigs

APA, Harvard, Vancouver, ISO, and other styles

5

Tang, Yuxiang, Yihui Li, Rong Xu, et al. "Self-assembly of folic acid dextran conjugates for cancer chemotherapy." Nanoscale 10, no. 36 (2018): 17265–74. http://dx.doi.org/10.1039/c8nr04657c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Plavšić, Marta, Senka Terzic, Marijan Ahel, and C. M. G. van den Berg. "Folic acid in coastal waters of the Adriatic Sea." Marine and Freshwater Research 53, no. 8 (2002): 1245. http://dx.doi.org/10.1071/mf02044.

Full text

Abstract:

The concentration of folic acid (FA), an important constituent of the vitamin B group, was determined over a period of 2 years in the water column of a small meromictic saline lake on the eastern Adriatic coast (Rogoznica Lake), as well as in the western part of the northern Adriatic Sea. The FA concentration was over the range of 0.1–13.5 nM in the oxic part of Rogoznica Lake, and 0.1–22 nM in the northern Adriatic, with a maximum of 22 nM in the upper layer of the water column, possibly caused by the impact of Po River freshets on the FA concentrations. A weak but statistically significant c

APA, Harvard, Vancouver, ISO, and other styles

7

Fajardo, Violeta, and Gregorio Varela-Moreiras. "Efficacy of Adding Folic Acid to Foods." International Journal for Vitamin and Nutrition Research 82, no. 3 (2012): 177–86. http://dx.doi.org/10.1024/0300-9831/a000109.

Full text

Abstract:

In the past, food fortification along with nutritional education and the decrease in food costs relative to income have proven successful in eliminating common nutritional deficiencies. These deficiencies such as goiter, rickets, beriberi, and pellagra have been replaced with an entirely new set of emergent deficiencies that were not previously considered a problem [e.g., folate and neural tube defects (NTDs)]. In addition, the different nutrition surveys in so-called affluent countries have identified shortfalls of nutrients specific to various age groups and/or physiological status. Comp

APA, Harvard, Vancouver, ISO, and other styles

8

Mutavdzin, Slavica, Kristina Gopcevic, Sanja Stankovic, Jovana Jakovljevic Uzelac, Milica Labudovic Borovic, and Dragan Djuric. "The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats." Canadian Journal of Physiology and Pharmacology 97, no. 9 (2019): 893–901. http://dx.doi.org/10.1139/cjpp-2019-0027.

Full text

Abstract:

Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. There were 4 groups: control (physiological saline 1 mL/kg, i.p., 28 days), DM (streptozotocin [STZ] 100 mg/kg in physiological saline, i.p., 1 day), folic acid (FA; 5 mg/kg, i.p., 28 days), and DM+FA (STZ 100 mg/kg, i.p., 1 day and folic acid 5 mg/kg, i.p., 28 days). Our results demonstrated increase

APA, Harvard, Vancouver, ISO, and other styles

9

Roebothan, Barbara V., Joy Carmichael, Valerie Barter, Jane Aucoin, and Madonna Murphy. "Mandatory Folic Acid Fortification: In Newfoundland and Labrador." Canadian Journal of Dietetic Practice and Research 68, no. 3 (2007): 143–45. http://dx.doi.org/10.3148/68.3.2007.143.

Full text

Abstract:

Purpose: Dietary folic acid (FA) intakes were analyzed in random samples of 302 young women (aged 18 to 34) and 337 seniors (aged 65 to 74) residing in Newfoundland and Labrador (NL). The analyses were an attempt to estimate the amount of FA they would consume solely because of mandatory fortification of foods. Methods: Secondary analysis was performed on raw data collected through single 24-hour recalls as part of a larger study. Results: The dietary FA contributed by fortified foods eaten in the specified amounts was estimated to be 136 to 148 mcg/day (226 to 247 DFE/day) for young women and

APA, Harvard, Vancouver, ISO, and other styles

10

Jin, Shaoming, Zhongyao Du, Huiyuan Guo, Hao Zhang, Fazheng Ren, and Pengjie Wang. "Novel Targeted Anti-Tumor Nanoparticles Developed from Folic Acid-Modified 2-Deoxyglucose." International Journal of Molecular Sciences 20, no. 3 (2019): 697. http://dx.doi.org/10.3390/ijms20030697.

Full text

Abstract:

The glucose analog, 2-deoxyglucose (2-DG), specifically inhibits glycolysis of cancer cells and interferes with the growth of cancer cells. However, the excellent water solubility of 2-DG makes it difficult to be concentrated in tumor cells. In this study, a targeted nano-pharmacosome was developed with folic acid-modified 2-DG (FA-2-DG) by using amino ethanol as a cleavable linker. FA-2-DG was able to self-assemble, forming nano-particles with diameters of 10–30 nm. The biological effects were evaluated with cell viability assays and flow cytometry analysis. Compared with a physical mixture o

APA, Harvard, Vancouver, ISO, and other styles

11

Jin, Shaoming, Zhongyao Du, Pengjie Wang, et al. "2-Deoxyglucose-Modified Folate Derivative: Self-Assembling Nanoparticle Able to Load Cisplatin." Molecules 24, no. 6 (2019): 1084. http://dx.doi.org/10.3390/molecules24061084.

Full text

Abstract:

Folic acid has been widely introduced into nano-drug delivery systems to give nanoparticle-targeted characteristics. However, the poor water solubility of folic acid may hinder the exploitation of its ability to load antineoplastic drugs. In the present study, we designed a new folate derivative (FA-2-DG) synthesized from folic acid and 2-Deoxyglucose (2-DG). The aim of this study was to evaluate the self-assembly characteristics of FA-2-DG, and its ability of loading cisplatin. The critical micelle concentration was 7.94 × 10−6 mol L−1. Fourier transform infrared spectroscopy indicated that h

APA, Harvard, Vancouver, ISO, and other styles

12

Sharman Moser, Sarah, Maayan Rabinovitch, Ran Rotem, Gideon Koren, Varda Shalev, and Gabriel Chodick. "Parity and the use of folic acid supplementation during pregnancy." BMJ Nutrition, Prevention & Health 2, no. 1 (2019): 30–34. http://dx.doi.org/10.1136/bmjnph-2019-000024.

Full text

Abstract:

ObjectiveFolic acid (FA) supplementation has long been recommended before and during pregnancy to reduce the risk of neural tube defects. Factors influencing adherence to FA supplementation have been extensively evaluated, but little is known on the effect of parity. This study comes to examine the association between parity and maternal use of FA prior to and during pregnancy.MethodsIn this retrospective population-based study, we identified mothers (N=228 555) of all children (N=578 204) born between the years 2000 and 2016 among members of a large health provider in Israel. Data on FA suppl

APA, Harvard, Vancouver, ISO, and other styles

13

Song, Huijuan, Chang Su, Wenyu Cui, et al. "Folic Acid-Chitosan Conjugated Nanoparticles for Improving Tumor-Targeted Drug Delivery." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/723158.

Full text

Abstract:

Objective. To prepare folic acid-chitosan conjugated nanoparticles (FA-CS NPs) and evaluate their targeting specificity on tumor cells.Methods. Chitosan (CS) NPs were prepared by ionic cross linking method, and folic acid (FA) was conjugated with CS NPs by electrostatic interaction. The properties of NPs were investigated, and doxorubicin hydrochloride (Dox) as a model drug was encapsulated for investigating drug release patternin vitro. The cytotoxicity and cellular uptake of FA-CS NPs were also investigated.Results. The results reveal that the obtained FA-CS NPs were monodisperse nanoparticl

APA, Harvard, Vancouver, ISO, and other styles

14

Li, Qian, Shangzhi Xu, Xi Chen, et al. "Folic Acid Supplement Use and Increased Risk of Gestational Hypertension." Hypertension 76, no. 1 (2020): 150–56. http://dx.doi.org/10.1161/hypertensionaha.119.14621.

Full text

Abstract:

Current results regarding the effect of folic acid (FA) supplement use on gestational hypertension (GH) and preeclampsia are limited and inconsistent. We aimed to investigate whether FA supplement use was associated with GH and preeclampsia. Participants from the Tongji Maternal and Child Health Cohort with information on periconceptional FA supplement use and diagnosis of GH/preeclampsia were included (n=4853). Robust Poisson regression was used to assess the association of FA supplement use and GH and preeclampsia. Among the 4853 participants in this study, 1161 (23.9%) and 161 (3.3%) women

APA, Harvard, Vancouver, ISO, and other styles

15

Parın, Fatma Nur, and Kenan Yıldırım. "Preparation and Characterisation of Vitamin-Loaded Electrospun Nanofibres as Promising Transdermal Patches." Fibres and Textiles in Eastern Europe 29, no. 1(145) (2021): 17–25. http://dx.doi.org/10.5604/01.3001.0014.3148.

Full text

Abstract:

In this study, bioactive fibers were produced using polyvinyl alcohol (PVA), gelatin, polyvinyl pyrolidone (PVP) as a polymer matrix and different amounts of folic acid (FA) as an vitamin by using electrospinning method. Loading of the folic acid in the polymers was determined by the Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), morphologies and average diameters were analyzed by Scanning Electron Microscopy (SEM) and Thermal Gravimetric Analysis (TGA) was applied for determining thermal behaviors.The FTIR spectra TGA showed the successful incorporation of fo

APA, Harvard, Vancouver, ISO, and other styles

16

Gautam, Nagsen, Pavan Puligujja, Shantanu Balkundi, et al. "Pharmacokinetics, Biodistribution, and Toxicity of Folic Acid-Coated Antiretroviral Nanoformulations." Antimicrobial Agents and Chemotherapy 58, no. 12 (2014): 7510–19. http://dx.doi.org/10.1128/aac.04108-14.

Full text

Abstract:

ABSTRACTThe drug delivery platform for folic acid (FA)-coated nanoformulated ritonavir (RTV)-boosted atazanavir (FA-nanoATV/r) using poloxamer 407 was developed to enhance cell and tissue targeting for a range of antiretroviral drugs. Such formulations would serve to extend the drug half-life while improving the pharmacokinetic profile and biodistribution to reservoirs of human immunodeficiency virus (HIV) infection. To this end, we now report enhanced pharmacokinetics and drug biodistribution with limited local and systemic toxicities of this novel nanoformulation. The use of FA as a targetin

APA, Harvard, Vancouver, ISO, and other styles

17

Duy Quang, Dao. "ANTIOXIDANT PROPERTIES OF FOLIC ACID: A DFT STUDY." Vietnam Journal of Science and Technology 56, no. 4A (2018): 39. http://dx.doi.org/10.15625/2525-2518/56/4a/12904.

Full text

Abstract:

Antioxidant activity of folic acid (FA) was investigated via two main antioxidant mechanisms: hydrogen atom transfer (HAT) and single electron transfer (SET) at the DFT/B3LYP/6-311G(d,p) level of theory. The characterizing thermochemical properties such as bond dissociation enthalpies (BDEs), ionization energy (IE) and electron affinity (EA) were calculated in the gas phase. Analyses of HOMOs distribution shows that the postions which easily donate electrons to free radicals are essentially found at C ring, while the positions which easily accept electrons (LUMOs) from radicals are mainly situ

APA, Harvard, Vancouver, ISO, and other styles

18

Burdge, Graham C., and Karen A. Lillycrop. "Folic acid supplementation in pregnancy: are there devils in the detail?" British Journal of Nutrition 108, no. 11 (2012): 1924–30. http://dx.doi.org/10.1017/s0007114512003765.

Full text

Abstract:

Maternal folic acid (FA) supplementation is well recognised to protect against neural tube defects. Folate is a critical cofactor in one-carbon metabolism involved in the epigenetic regulation of transcription that underpins development. Thus, it is possible that maternal FA supplementation may have additional, unforeseen persistent effects in the offspring. This is supported by the modification by maternal supplementation with one-carbon donors and FA of the epigenetic regulation of offspring phenotype in mutant mice. The present article reviews studies in human subjects and experimental anim

APA, Harvard, Vancouver, ISO, and other styles

19

Sereen, Khadira, Vijayalakshmi K, Priya Nagappan, and Shinu Balima. "EFFECT OF SESAMOL IN ASSOCIATION WITH FOLIC ACID ON 6-OHDA INDUCED PARKINSONIAN ANIMALS- BIOCHEMICAL, NEUROCHEMICAL AND HISTOPATHOLOGICAL EVIDENCE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 46. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.12961.

Full text

Abstract:

Objective: Parkinson’s disease (PD) is the world’s second neurodegenerative disorder. Degeneration of dopaminergic neurons is the hallmark of the disease. Here is a novel approach to treat PD with a phenolic compound Sesamol (SA) and in combination with Folic acid (FA).Methods: The study was designed with five groups of animals and 6 rats in each group. The rats was infused with 6-hydroxydopamine (10μg/2μl in 0.1% ascorbic acid saline) once for the development of PD, Group 1(control), Group 2(Lesion), Group 3(Lesion+ SA), Group 4(Lesion + SA+ FA) and Group 5(Lesion+ L-dopa). The biochemical pa

APA, Harvard, Vancouver, ISO, and other styles

20

Fan, Lei, Jianquan Wang, Chengwan Xia, et al. "Glutathione-sensitive and folate-targeted nanoparticles loaded with paclitaxel to enhance oral squamous cell carcinoma therapy." Journal of Materials Chemistry B 8, no. 15 (2020): 3113–22. http://dx.doi.org/10.1039/c9tb02818h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Wang, Jing, and Jun Liu. "PEI–folic acid modified carbon nanodots for cancer cell-targeted delivery and two-photon excitation imaging." RSC Advances 6, no. 24 (2016): 19662–68. http://dx.doi.org/10.1039/c5ra27249a.

Full text

Abstract:

PET–folic acid coated carbon nanodots (CDots) as the targeting fluorescence imaging probe agents. Folic acid (FA) was used as the targeting ligand to enhance the CDots' binding capability and penetration into the target cancer cells.

APA, Harvard, Vancouver, ISO, and other styles

22

Wang, By Song, Jing Wang, and Ji-Yao Chen. "Conjugates of folic acids with zinc aminophthalocyanine for cancer cell targeting and photodynamic therapy by one-photon and two-photon excitations." J. Mater. Chem. B 2, no. 11 (2014): 1594–602. http://dx.doi.org/10.1039/c3tb21620a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Shi, Xiaoxin, Dongxiu He, Guotao Tang, et al. "Fabrication and characterization of a folic acid-bound 5-fluorouracil loaded quantum dot system for hepatocellular carcinoma targeted therapy." RSC Advances 8, no. 35 (2018): 19868–78. http://dx.doi.org/10.1039/c8ra01025k.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Mantovani, Elena, Francesca Filippini, Renata Bortolus, and Massimo Franchi. "Folic Acid Supplementation and Preterm Birth: Results from Observational Studies." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/481914.

Full text

Abstract:

Introduction. Folic acid (FA) supplementation is recommended worldwide in the periconceptional period for the prevention of neural tube defects. Due to its involvement in a number of cellular processes, its role in other pregnancy outcomes such as miscarriage, recurrent miscarriage, low birth weight, preterm birth (PTB), preeclampsia, abruptio placentae, and stillbirth has been investigated. PTB is a leading cause of perinatal mortality and morbidity; therefore its association with FA supplementation is of major interest. The analysis of a small number of randomized clinical trials (RCTs) has

APA, Harvard, Vancouver, ISO, and other styles

25

Cheng, Fang-Fang, Panpan Sun, Wei-Wei Xiong, et al. "Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation." Analyst 144, no. 9 (2019): 3103–10. http://dx.doi.org/10.1039/c8an02450b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Cawley, Shona, Laura Mullaney, Rachel Kennedy, Maria Farren, Daniel McCartney, and Michael J. Turner. "Duration of periconceptional folic acid supplementation in women booking for antenatal care." Public Health Nutrition 20, no. 2 (2016): 371–79. http://dx.doi.org/10.1017/s1368980016002585.

Full text

Abstract:

AbstractObjectiveTo provide accurate estimates of the commencement time, duration and dosage of folic acid (FA) supplementation taken by Irish women in the periconceptional period. The study also aimed to establish the factors associated with optimal FA supplementation practices.DesignCross-sectional observational study. Women’s clinical and sociodemographic details were computerised. Maternal weight and height were measured before calculating BMI. Detailed FA supplementation questionnaires were completed under the supervision of a trained researcher.SettingA large university maternity hospita

APA, Harvard, Vancouver, ISO, and other styles

27

Zhou, Yu, Yanming Han, Gaiyun Li, Sheng Yang, Fuquan Xiong, and Fuxiang Chu. "Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin." Nanomaterials 9, no. 2 (2019): 188. http://dx.doi.org/10.3390/nano9020188.

Full text

Abstract:

Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-

APA, Harvard, Vancouver, ISO, and other styles

28

Achón, M., E. Alonso-Aperte, N. Úbeda, and G. Varela-Moreiras. "Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats." British Journal of Nutrition 98, no. 3 (2007): 490–96. http://dx.doi.org/10.1017/s0007114507721499.

Full text

Abstract:

There are nationwide folic acid (FA) fortification programmes of staple foods established or under consideration in order to prevent neural tube defects. Universal FA fortification still remains controversial because of the concern that additional FA in the diets of population groups (e.g. children and elderly) not initially targeted for fortification may suffer adverse effects. However, dietary surveys regarding folate generally deal with adults and little is known about the consumption and long-term effects of fortified food and supplements in growing individuals. Recent reports from our lab

APA, Harvard, Vancouver, ISO, and other styles

29

Hajiallilo, Morteza, and Saeid Abbasi-Maleki. "The antinociceptive effects of folic acid using formalin and acetic acid tests in male mice." Journal of Shahrekord University of Medical Sciences 23, no. 2 (2021): 93–98. http://dx.doi.org/10.34172/jsums.2021.15.

Full text

Abstract:

Background and aims: Antidepressant agents such as imipramine are clinically used to control and treat different types of pain, especially neuropathic pain. Studies have shown the antidepressant-like activity of folic acid (FA). This study aimed to investigate the potential antinociceptive effects of FA using formalin and acetic acid tests in male mice. Methods: Sixty male albino mice (20-30 g) were randomly divided into 10 groups (n=6 in each group) of negative control, positive control (morphine or indomethacin), and FA (10, 15, and 30 mg/kg) groups. In the formalin test, duration of paw lic

APA, Harvard, Vancouver, ISO, and other styles

30

Liang, Xue Song, Feng Qing Zhao, and Li Xia Hao. "Research on Stability of Synthetic Folic Acid." Advanced Materials Research 781-784 (September 2013): 1215–18. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.1215.

Full text

Abstract:

This paper is mainly to investigate the stability of synthetic folic acid under different conditions, including pH, temperature, light, and the presence of antioxidants. The results show that folic acid gives a good stability in the buffer of pH 8.05~10.40, whose reservation ratio can reach more than 93.1% in 72 h, while the preservation ratio of folic acid reduce to 23% in the buffer of pH1.95~6.40. Moreover, folic acid has a good stability in the buffer of pH 5.39~10.40, after water bath at 100°C for 2 h. Folic acid exhibits a good stability under the condition of weak illumination intensity

APA, Harvard, Vancouver, ISO, and other styles

31

Xuan, Guangshan, Min Zhang, Yang Chen, Shan Huang, and Imshik Lee. "Design and Characterization of a Cancer-Targeted Drug Co-Delivery System Composed of Liposomes and Selenium Nanoparticles." Journal of Nanoscience and Nanotechnology 20, no. 9 (2020): 5295–304. http://dx.doi.org/10.1166/jnn.2020.17882.

Full text

Abstract:

A drug co-delivery system composed of selenium nanoparticles (SeNPs) has attracted increasing interest due to its ability to increase the anticancer efficacy against multidrug-resistant cancer cells. In this study, a cancer-targeted drug co-delivery system combining fluorescein-loaded liposomes and SeNPs was designed and evaluated. The system was developed by coating SeNPs and fluorescein-loaded liposomes with folic acid-chitosan conjugates (FA-CS-SeNPs-Lips). Folic acid-chitosan conjugates (FA-CS) were synthesized by coupling folic acid (FA) with chitosan (CS), and the structure was confirmed

APA, Harvard, Vancouver, ISO, and other styles

32

Meng, Lei, Jian-Hang Yin, Yaqing Yuan, and Na Xu. "11-Mercaptoundecanoic acid capped gold nanoclusters as a fluorescent probe for specific detection of folic acid via a ratiometric fluorescence strategy." RSC Advances 8, no. 17 (2018): 9327–33. http://dx.doi.org/10.1039/c8ra00481a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Ha, Zhao, Binns, et al. "Low Prevalence of Folic Acid Supplementation during Pregnancy: A Multicenter Study in Vietnam." Nutrients 11, no. 10 (2019): 2347. http://dx.doi.org/10.3390/nu11102347.

Full text

Abstract:

Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects (NTDs), but little information is known about its use in Vietnam. It is important that FA supplements start to be taken when planning a pregnancy and continued through the first trimester to prevent NTDs, as the neural tube closes in the first month of pregnancy. However, FA supplementation in Vietnam is usually recommended to commence from the first antenatal visit, which is usually at 16 weeks, and very few women take FA before their first visit. This multicenter study aimed to determine the preval

APA, Harvard, Vancouver, ISO, and other styles

34

Liu, Jufen, Zhiwen Li, Rongwei Ye, Aiguo Ren, and Jianmeng Liu. "Folic acid supplementation and risk for congenital limb reduction defects in China." International Journal of Epidemiology 48, no. 6 (2019): 2010–17. http://dx.doi.org/10.1093/ije/dyz130.

Full text

Abstract:

Abstract Background Folic acid (FA) supplementation prevents neural tube defects, but there are mixed results for its ability to prevent limb reduction defects. We examined whether a preventive effect of FA supplementation exists for congenital limb reduction defects in a large population in China. Methods Data from a large population-based cohort study in China were used to evaluate the effects of FA supplementation on birth defects. All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural congenital anomalies, regardless o

APA, Harvard, Vancouver, ISO, and other styles

35

Krawczyk, Barbara, Dominik Szczukocki, Justyna Stachniuk, et al. "The determination of the folic acid and its selected derivatives." Mediterranean Journal of Chemistry 3, no. 4 (2014): 1003–12. http://dx.doi.org/10.13171/mjc.3.4.2014.09.24.12.29.

Full text

Abstract:

Folic acid (FA) belongs to vitamins from group B. The most commonly used drug from a group of structural analogues of FA is methotrexate (MTX), showing antiproliferatative properties. Unfortunately, the action of MTX is not selective. Toxic effects of methotrexate may be partially abolished by the use of leucovorin (calcium salt of folinic acid, FNA) in conserving therapy. The aim of the presented paper was to develop a new analytical procedure using the capillary electrophoresis, allowing the separation and the quantitative marking of the folic acid, methotrexate and calcium salt of folinic a

APA, Harvard, Vancouver, ISO, and other styles

36

Lamers, Yvonne, Amanda J. MacFarlane, Deborah L. O'Connor, and Bénédicte Fontaine-Bisson. "Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines." American Journal of Clinical Nutrition 108, no. 6 (2018): 1357–68. http://dx.doi.org/10.1093/ajcn/nqy212.

Full text

Abstract:

ABSTRACT The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consumin

APA, Harvard, Vancouver, ISO, and other styles

37

Bostom, Andrew G., Gintaras Liaugaudas, Paul F. Jacques, Irwin H. Rosenberg, and Jacob Selhub. "Total Homocysteine Lowering Treatment Among Coronary Artery Disease Patients in the Era of Folic Acid Fortified Cereal Grain Flour." Circulation 103, suppl_1 (2001): 1367. http://dx.doi.org/10.1161/circ.103.suppl_1.9998-86.

Full text

Abstract:

P86 Background: The prevalence of both deficient plasma folate status, and elevated total (t) plasma levels of the putatively atherothrombotic amino acid homocysteine (Hcy), have been dramatically reduced since the recent advent of fortification of all enriched cereal grain flour products with physiological amounts (i.e., 140 μg/ 100 g flour) of folic acid. Against this new background fortification, we evaluated the tHcy-lowering efficacy of pharmacological dose, folic acid based B-vitamin supplementation among stable coronary artery disease (CAD) patients. Methods and Results: Using a 2x2 fac

APA, Harvard, Vancouver, ISO, and other styles

38

Moens, An L., Christiaan J. Vrints, Marc J. Claeys, Jean-Pierre Timmermans, Hunter C. Champion, and David A. Kass. "Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 5 (2008): H1971—H1977. http://dx.doi.org/10.1152/ajpheart.91503.2007.

Full text

Abstract:

Folic acid (FA) is a member of the B-vitamin family with cardiovascular roles in homocysteine regulation and endothelial nitric oxide synthase (eNOS) activity. Its interaction with eNOS is thought to be due to the enhancement of tetrahydrobiopterin bioavailability, helping maintain eNOS in its coupled state to favor the generation of nitric oxide rather than oxygen free radicals. FA also plays a role in the prevention of several cardiac and noncardiac malformations, has potent direct antioxidant and antithrombotic effects, and can interfere with the production of the endothelial-derived hyperp

APA, Harvard, Vancouver, ISO, and other styles

39

Zhloba, A. A., and T. F. Subbotina. "THE EVALUATION OF HOMOARGININE AND FOLIC ACID IN PATIENTS WITH ARTERIAL HYPERTENSION." Russian Clinical Laboratory Diagnostics 65, no. 8 (2020): 474–81. http://dx.doi.org/10.18821/0869-2084-2020-65-8-474-481.

Full text

Abstract:

According to current data, a low level of folic acid (FA) contributes to the progression of arterial hypertension (AH), affecting the metabolism of cells that are involved in the vascular tone regulation, such as hypothalamic astrocytes of nervous tissue. It is also known that the level of FA in the nervous tissue and cerebrospinal fluid is 2-3 times higher than in plasma. There is another metabolic marker of cardiovascular diseases, the level of plasma homoarginine (hArg). The decrease in the level of plasma hArg is also known as a diagnostic sign. In our study, we established that in patient

APA, Harvard, Vancouver, ISO, and other styles

40

Liu, Jufen, Zhiwen Li, Rongwei Ye, Aiguo Ren, and Jianmeng Liu. "Folic acid supplementation and risk for congenital hydrocephalus in China." Public Health Nutrition 24, no. 13 (2021): 4238–44. http://dx.doi.org/10.1017/s136898002100029x.

Full text

Abstract:

AbstractObjective:We examined whether folic acid (FA) supplementation prevented congenital hydrocephalus (CH) in more than 200 000 births in China.Design:A large population-based cohort study.Setting:All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural birth defects regardless of gestational week were recorded. The prevalence of births with CH was classified by maternal characteristics and FA supplementation. CH was diagnosed in accordance with code 742.3 of the International Classification of Diseases, Ninth Revision, C

APA, Harvard, Vancouver, ISO, and other styles

41

Mise, Nathan, Mayumi Ohtsu, Akihiko Ikegami, et al. "Concentration of folic acid (FA) in serum of Japanese pregnant women." Reviews on Environmental Health 35, no. 3 (2020): 277–80. http://dx.doi.org/10.1515/reveh-2020-0014.

Full text

Abstract:

AbstractObjectivesExposure to inorganic arsenic (iAs) is a world-wide health concern. We reported that Japanese children and pregnant women are exposed to moderate levels of iAs through food. Reducing iAs contamination from foods of high iAs is an important issue unique in Japan. Integrated iAs is methylated to less toxic organic forms, and S-adenosyl-L-methyonine (SAM), a common methyl-donor of DNA and histones, is utilized in this process. Chronic consumption of SAM by iAs metabolism due to exposure to iAs might alter the epigenetic modification of genome. The SAM biosynthesis pathway is dep

APA, Harvard, Vancouver, ISO, and other styles

42

Jiang, Xuheng, Kui Gao, Daopan Hu, Huanhuan Wang, Shujuan Bian, and Yong Chen. "Ion-transfer voltammetric determination of folic acid at meso-liquid–liquid interface arrays." Analyst 140, no. 8 (2015): 2823–33. http://dx.doi.org/10.1039/c4an02011a.

Full text

Abstract:

Voltammetric studies on the simple ion transfer (IT) behaviors of an important water-soluble B-vitamin, folic acid (FA), at the liquid–liquid (L–L) interface were firstly performed and applied as a novel detection method for FA under physiological conditions. This work provides a new and attractive strategy for the detection of FA<sup>−</sup> and other biological anions.

APA, Harvard, Vancouver, ISO, and other styles

43

Zhu, Xiao-Li, Jing-Cheng Tang, and Bing-Jiu Xu. "The Synthesis of the Folate Acid Quantum Dots and Its Endocytosis in the Hepatoma Cells Mediated by the Folate Receptor." Journal of Biomaterials and Tissue Engineering 9, no. 6 (2019): 770–77. http://dx.doi.org/10.1166/jbt.2019.2043.

Full text

Abstract:

Objectives: To synthesize folate acid conjugated quantum dots (QDs) by a simple and green method and explore endocytosis of the QD-folic acid conjugates (FA-QDs) into hepG2 cells. Methods: CdS QDs were prepared using stearic acid as synthetic medium, and were conjugated with mercaptoacetic acid (MAA) to be water-soluble. Then folic acid moiety was coupled to the surface of the QDs using EDC (1-ethyl-3-(3-dimethylamino propyl)carbodiimide) as a coupling agent. The CdS QDs and FA-QDs were characterized by X-ray spectroscopy (XRD), transmission electron microscopy (TEM), spectro fluorimetry and i

APA, Harvard, Vancouver, ISO, and other styles

44

Lamprou, Eleni, Spyridon Mourtas, Maria Mantzari, Antonia Marazioti, Foteini Gkartziou, and Sophia G. Antimisiaris. "Folic Acid—Targeted Doxorubicin Drug Delivery System for Triple-Negative Breast Cancer Treatment." Proceedings 78, no. 1 (2020): 4. http://dx.doi.org/10.3390/iecp2020-08660.

Full text

Abstract:

Triple-negative breast cancer (TNBC) is a highly aggressive type of cancer with limited therapeutic options. However, this type of cancer cells has shown overexpression of folate receptors, which bind with folic acid (FA) with high affinity. This feature can be used for targeting of nanocarriers, such as liposomes. In order to further examine the potential of increased efficacy by targeting the folate receptor, we prepared folate conjugated liposomes (DSPC/Chol/PEG/DSPE-PEG-FA) and loaded them with doxorubicin (DOX), an anticancer drug. For this, we first synthesized and verified the conjugate

APA, Harvard, Vancouver, ISO, and other styles

45

Di Tinno, Alessio, Rocco Cancelliere, and Laura Micheli. "Determination of Folic Acid Using Biosensors—A Short Review of Recent Progress." Sensors 21, no. 10 (2021): 3360. http://dx.doi.org/10.3390/s21103360.

Full text

Abstract:

Folic acid (FA) is the synthetic surrogate of the essential B vitamin folate, alternatively named folacin, pteroylglutamic acid or vitamin B9. FA is an electroactive compound that helps our body to create and keep our cells healthy: it acts as the main character in a variety of synthetic biological reactions such as the synthesis of purines, pyrimidine (thus being indirectly implied in DNA synthesis), fixing and methylation of DNA. Therefore, physiological folate deficiency may be responsible for severe degenerative conditions, including neural tube defects in developing embryos and megaloblas

APA, Harvard, Vancouver, ISO, and other styles

46

Yang, Tsung-Ying, Gee-Chen Chang, Shih-Lan Hsu, Yi-Rou Huang, Ling-Yen Chiu, and Gwo-Tarng Sheu. "Effect of Folic Acid and VitaminB12on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/389046.

Full text

Abstract:

Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy. Clinically, supplementation with high doses of folic acid (FA) and vitamin B12(VB12) lowers MTA cytotoxicities. An antagonistic effect of FA/VB12 on MTA efficacy has been proposed. However, patients who receive FA/VB12 show better tolerance to MTA with improved survival. The aims of this study are to investigate the modulation of FA and VB12 on MTA drug efficacy in human nonsmall cell lung cancer (NSCLC) cell lines. The sensitivities of cells, apoptosis, and MTA-regulated proteins were characterized to determ

APA, Harvard, Vancouver, ISO, and other styles

47

Tupe, Rashmi Santosh, and Vaishali Vilas Agte. "Role of zinc along with ascorbic acid and folic acid during long-term in vitro albumin glycation." British Journal of Nutrition 103, no. 3 (2009): 370–77. http://dx.doi.org/10.1017/s0007114509991929.

Full text

Abstract:

The present study aimed to investigate the role of Zn alone and in the presence of ascorbic acid (AA) and folic acid (FA) in albumin glycation. Glycation was performed by incubations of bovine serum albumin with glucose at 37°C along with Zn, AA or FA separately and Zn+AA or Zn+FA for 150 d. Glycation-mediated modifications were monitored as fluorescence of advanced glycation endproducts, carbonyl formation, β aggregation (thioflavin T and Congo red dyes), albumin-bound Zn, thiol groups and glycated aggregate's toxicity in HepG2 cells. Zn inhibited glycation and β aggregation, probably due to

APA, Harvard, Vancouver, ISO, and other styles

48

Sen, S., A. Manzoor, M. Deviasumathy, and Cindy Newton. "Maternal knowledge, attitude and practice regarding folic acid intake during the periconceptional period." Public Health Nutrition 4, no. 4 (2001): 909–12. http://dx.doi.org/10.1079/phn2001123.

Full text

Abstract:

AbstractObjective:To study the knowledge, attitude and practice of pregnant women regarding periconceptional folic acid (FA) intake.Design:Questionnaire-based prospective study.Setting:Antenatal clinic of a District General Hospital.Subjects:Three-hundred pregnant women in an antenatal clinic.Results:Nearly all (298/300) had heard of FA. A majority (275/300, 91%) knew that FA could prevent neural tube defects, and married women (P <0.001), those with higher education (P <0.001), those of Social Classes 1–3 (P <0.01) and women over 30 years of age (P <0.05) were more likely to be th

APA, Harvard, Vancouver, ISO, and other styles

49

Partearroyo, Teresa, Juliana Pérez-Miguelsanz, Ángel Peña-Melián, Carmen Maestro-de-las-Casas, Natalia Úbeda, and Gregorio Varela-Moreiras. "Low and high dietary folic acid levels perturb postnatal cerebellar morphology in growing rats." British Journal of Nutrition 115, no. 11 (2016): 1967–77. http://dx.doi.org/10.1017/s0007114516001008.

Full text

Abstract:

AbstractThe brain is particularly sensitive to folate metabolic disturbances, because methyl groups are critical for brain functions. This study aimed to investigate the effects of different dietary levels of folic acid (FA) on postnatal cerebellar morphology, including the architecture and organisation of the various layers. A total of forty male OFA rats (a Sprague–Dawley strain), 5 weeks old, were classified into the following four dietary groups: FA deficient (0 mg/kg FA); FA supplemented (8 mg/kg FA); FA supra-supplemented (40 mg/kg FA); and control (2 mg/kg FA) (alln10 per group). Rats w

APA, Harvard, Vancouver, ISO, and other styles

50

Rong, Rong, Qian Zhou, Jianxiong Lin, et al. "Maintained Folic Acid Supplementation Reduces the Risk of Mortality in Continuous Ambulatory Peritoneal Dialysis Patients." Blood Purification 45, no. 1-3 (2017): 28–35. http://dx.doi.org/10.1159/000480222.

Full text

Abstract:

Background: The association between folic acid (FA) supplementation and mortality in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear. Methods: FA exposure was calculated as a percentage of cumulative duration of drug usage to total follow-up duration (FA%). A total of 1,358 patients were classified by a cutoff value of FA%. The association of FA with mortality was evaluated using Cox proportional hazards models. Results: The cutoff value of FA% for predicting mortality was <34% at a median follow-up of 40.7 months. FA ≥34% was associated with decreased risk for all-caus

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!