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Journal articles on the topic 'Folic acid Metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Khaitovich, M. V. "Folates: Modern Pregnant Health Support." HEALTH OF WOMAN, no. 4(150) (May 30, 2020): 37–42. http://dx.doi.org/10.15574/hw.2020.150.37.

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Folates (folic acid-based chemical compounds) got their name from the Latin “folio” - “leaf”, since they were first synthesized from spinach leaves, in which vitamin B9 is found in maximum quantities. As an important cofactor in carbon metabolism, folates are involved in the most important metabolic processes in the body, in particular, they play a key role in the synthesis of nucleotides and DNA replication. The article provides information on the physiological role of folates, their metabolism and its genetic aspects. The clinical significance of folate deficiency is examined, their sources

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Lucock, Mark. "Folic Acid: Beyond Metabolism." Journal of Evidence-Based Complementary & Alternative Medicine 16, no. 2 (2011): 102–13. http://dx.doi.org/10.1177/1533210110392950.

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Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate values commonly exceeding the upper range of calibration. The synthetic analog (pteroylmonoglutamic acid) prevents neural tube defects and lowers homocysteine, both positive attributes, yet negative correlates of pteroylmonoglutamic acid are increasingly reported. These involve increased risk for common cancers (ie, colon, breast, prostate) and antimetabolite effects on natural killer cells and at dihydrofolate reductas

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3

Metz, Jack. "Folic Acid Metabolism and Malaria." Food and Nutrition Bulletin 28, no. 4_suppl4 (2007): S540—S549. http://dx.doi.org/10.1177/15648265070284s407.

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Pellis, Linette, Yvonne Dommels, Dini Venema, et al. "High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells." British Journal of Nutrition 99, no. 4 (2007): 703–8. http://dx.doi.org/10.1017/s0007114507824147.

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Folate, a water-soluble B vitamin, is a cofactor in one-carbon metabolism and is essential for DNA synthesis, amino acid interconversion, methylation and, consequently, normal cell growth. In animals with existing pre-neoplastic and neoplastic lesions, folic acid supplementation increases the tumour burden. To identify processes that are affected by increased folic acid levels, we compared HT29 human colon cancer cells exposed to a chronic supplemental (100 ng/ml) level of folic acid to cells exposed to a normal (10 ng/ml) level of folic acid, in the presence of vitamin B12and other micronutri

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Sahar, Saniya. "Role of Folate and Folic Acid During Pregnancy." International Journal for Research in Applied Science and Engineering Technology 9, no. 12 (2021): 1488–92. http://dx.doi.org/10.22214/ijraset.2021.39295.

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Abstract: Pregnancy represents a period of fast tissue growth of maternal and foetal tissues that's related to enhanced energy and nutrient needs. Maternal nutrition throughout gestation period, has being essential for best offspring development, reducing long unwellness burden and for general health throughout life. Maternal Folate throughout pregnancy might have numerous roles in offspring health, as well as neurodevelopment and psychological feature performance in childhood. Folate is crucial for C1 metabolism, a network of pathways concerned in many biological processes as well as nucleoti

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Han, Xuhui, Bingqi Wang, Dongxu Jin, et al. "Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish." Biology 11, no. 1 (2021): 28. http://dx.doi.org/10.3390/biology11010028.

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Folic acid, one of the 13 essential vitamins, plays an important role in cardiovascular development. Mutations in folic acid synthesis gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with the occurrence of congenital heart disease. However, the mechanisms underlying the regulation of cardiac development by mthfr gene are poorly understood. Here, we exposed zebrafish embryos to excessive folate or folate metabolism inhibitors. Moreover, we established a knock-out mutant of mthfr gene in zebrafish by using CRISPR/Cas9. The zebrafish embryos of insufficient or excessive folic

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Ledowsky, Carolyn, Abela Mahimbo, Vanessa Scarf, and Amie Steel. "Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review." Nutrients 14, no. 13 (2022): 2715. http://dx.doi.org/10.3390/nu14132715.

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Background: In preconception and pregnancy, women are encouraged to take folic acid-based supplements over and above food intake. The upper tolerable limit of folic acid is 1000 mcg per day; however, this level was determined to avoid masking a vitamin B12 deficiency and not based on folic acid bioavailability and metabolism. This review’s aim is to assess the total all-source intake of folate in women of childbearing age and in pregnancy in high-income countries with folate food fortification programs. Methods: A systematic search was conducted in five databases to find studies published sinc

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James, A. Greenberg, J. Bell Stacey, Guan Yong, and Yu Yan-Hong. "Folic acid supplementation and pregnancy: more than just neural tube defect prevention." REPRODUCTIVE ENDOCRINOLOGY, no. 34 (April 30, 2017): 57–63. https://doi.org/10.18370/2309-4117.2017.34.57-63.

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Folate (vitamin B9) is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities). This article reviews the metabolism of folic acid, the appropriate use of folic acid supplementation in pregnancy, and the potential benefits of fol

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Gunnala, Siddarth, Lori M. Buhlman, and Nafisa M. Jadavji. "How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity." Nutrients 17, no. 7 (2025): 1286. https://doi.org/10.3390/nu17071286.

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Dietary folic acid supplementation is well known for playing a crucial role in the closure of the neural tube. Individuals have continued to increase dietary intake of folic acid in counties with mandatory fortication laws in place. Some studies have demonstrated adverse health effects in individuals with high dietary intake of folic acid. Nutrition is a modifiable risk factor for ischemic stroke. Specifically, elevated levels of homocysteine, they can be reduced by increasing intake of vitamins, such as folic acid, a B-vitamin. Hypoxia, when levels of oxygen are reduced, is a major component

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10

James A. Greenberg, Stacey J. Bell, Yong Guan, and Yan-Hong Yu. "Folic acid supplementation and pregnancy: more than just neural tube defect prevention." REPRODUCTIVE ENDOCRINOLOGY, no. 34 (April 30, 2017): 57–63. http://dx.doi.org/10.18370/2309-4117.2017.34.57-63.

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Folate (vitamin B9) is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities).This article reviews the metabolism of folic acid, the appropriate use of folic acid supplementation in pregnancy, and the potential benefits of foli

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11

SALIMOVA, Z. D., and M. F. DODKHOEVA. "FOLATE METABOLISM IN PREGNANCY." AVICENNA BULLETIN 24, no. 4 (2022): 502–13. http://dx.doi.org/10.25005/2074-0581-2022-24-4-502-513.

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The literature review examines the data on the role of folic acid in the human body, especially in women of the reproductive period. An analysis of research studies was conducted to assess the effect of folic acid and folate deficiency on organogenesis and placental formation. In addition, folate deficiency is associated with severe pregnancy complications, including placental abruption, spontaneous miscarriages, intrauterine growth retardation, and preeclampsia. Also, it plays a role in developing congenital malformations of the cardiovascular, nervous, visual and musculoskeletal systems. It

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Sid, Victoria, Nan Wu, Lindsei K. Sarna, Yaw L. Siow, James D. House, and Karmin O. "Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 10 (2015): R1215—R1225. http://dx.doi.org/10.1152/ajpregu.00260.2015.

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AMPK is an endogenous energy sensor that regulates lipid and carbohydrate metabolism. Nonalcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome with impaired lipid and glucose metabolism and increased oxidative stress. Our recent study showed that folic acid supplementation attenuated hepatic oxidative stress and lipid accumulation in high-fat diet-fed mice. The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved. Male C57BL/6J mice were fed a control diet (10%

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Bjelakovic, Gordana, Dusica Pavlovic, Tatjana Jevtovic та ін. "Vitamin Β12 and Folic Acid Effects on Polyamine Metabolism in Rat Liver". Pteridines 17, № 3 (2006): 90–94. http://dx.doi.org/10.1515/pteridines.2006.17.3.90.

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Abstract Polyamines, spennine, spermidine and putrescinc, small aliphatic nitrous bases, are normal constituents of microbial, plant and animal cells, where they fulfill an array of physiological roles. Metabolism of polyamines is associated with growth and differentiation of mammalian cells, spermine related to RNA and spermidine to DNA metabolism. Methyl-cobalamin, the coenzyme of methionine synthetase, catalyses the recycling of homocysteine to methionine using 5-methyltctrahydrofolate. By acceleration of methionine biosynthesis these vitamins may influence spermidine and spermine synthesis

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Capelli, Irene, Giuseppe Cianciolo, Lorenzo Gasperoni, et al. "Folic Acid and Vitamin B12 Administration in CKD, Why Not?" Nutrients 11, no. 2 (2019): 383. http://dx.doi.org/10.3390/nu11020383.

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Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death. Since traditional risk factors cannot fully explain such increased cardiovascular risk, interest in non-traditional risk factors, such as hyperhomocysteinemia and folic acid and vitamin B12 metabolism impairment, is growing. Although elevated homocysteine blood levels are often seen in patients with CKD and ESRD, whether hyperhomocysteinemia represents a reliable cardiovascular and mortality risk marker or a t

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15

Sazonova, A. P., Yu P. Milyutina, O. N. Bespalova, O. V. Pachuliia, I. V. Zalozniaia, and A. V. Korenevsky. "Effect of synthetic and reduced folic acid on methionine metabolism parameters in various experimental models with Wistar rats." Obstetrics, Gynecology and Reproduction 18, no. 5 (2024): 658–66. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2024.517.

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Introduction. Currently, folic acid preparations are administered during preconception period in an empirical manner. Along with synthetic folic acid, there also exists its reduced counterpart 5-methyltetrahydrofolate (5-MTHF). Manufacturers of the latter claim that 5-MTHF overcomes metabolic defects due to c.665C>T gene polymorphism in the methylenetetrahydrofolate reductase (MTHFR), and therefore it is superior to synthetic folic acid (pteroylmonoglutamic acid, PGA). However, no large-scale studies to confirm this hypothesis have been conducted yet.Aim: to assess an effect of various foli

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16

Hagberg, Bengt, and Andreas Killander. "ANTICONVULSIVE DRUGS AND DISTURBED FOLIC ACID METABOLISM." Developmental Medicine & Child Neurology 9, no. 5 (2008): 647–48. http://dx.doi.org/10.1111/j.1469-8749.1967.tb02342.x.

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17

Williams, J. R. B. "Folic Acid Metabolism of Human Marrow Cells." Scandinavian Journal of Haematology 2, no. 2 (2009): 155–66. http://dx.doi.org/10.1111/j.1600-0609.1965.tb01291.x.

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18

Price, John. "Folic acid metabolism in health and disease." Trends in Food Science & Technology 2 (January 1991): 260. http://dx.doi.org/10.1016/0924-2244(91)90712-r.

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19

Liang, Shuang, Yuanpeng Zhou, Huijun Wang, et al. "The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/560183.

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Objective. To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism.Methods. Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were measured. Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to analyze the joint effects of SNPs on the Hcy level.Results. SNPs of MTHFR (rs1801133 and rs3733965) were significantly associated with maternal serum Hcy level. In the different genotyp

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20

TAKAMURA, NOBORU, TATSURO KONDOH, SYOHEI OHGI, et al. "ABNORMAL FOLIC ACID HOMOCYSTEINE METABOLISM AS MATERNAL RISK FACTORS FOR DOWN SYNDROME IN JAPAN." Health and Ecology Issues 1, no. 1 (2004): 41–44. http://dx.doi.org/10.51523/2708-6011.2004-1-1-7.

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Department of Public Health, Department of Pediatrics, Department of Molecular Epidemiology, Biostatistics Section and Department of Molecular Medicine,Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Background: Japan has been considered as «a folate sufficient area», since traditional Japanese food contains an adequate amount of folic acid. However, the recent westernized food style of young Japanese mothers may affect the intake of folic acid among them. This food style may contribute to the occurrence of Down syndrome, which has proved to be linked to abnormal fo

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21

Köse, Süleyman, Saniye Sözlü, Hatice Bölükbaşi, Nüket Ünsal, and Makbule Gezmen-Karadağ. "Obesity is associated with folate metabolism." International Journal for Vitamin and Nutrition Research 90, no. 3-4 (2020): 353–64. http://dx.doi.org/10.1024/0300-9831/a000602.

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Abstract. Objective: The aim of the present study is to perform a systemic review of the previous studies executed on the association between obesity and folate. Method: In the present research, the selected keywords were scanned on the PubMed, Web of Science, Cochrane and Lilac databases between May and June, 2017 through Gazi University’s network. In total, 4236 clinical, randomized controlled, cross-sectional and prospective studies were determined and 17 of these that specifically fit the aims of the present research were reviewed. This study involved an electronic literature search of dat

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Cao, Rui, Jun Xie, and Li Zhang. "Abnormal methylation caused by folic acid deficiency in neural tube defects." Open Life Sciences 17, no. 1 (2022): 1679–88. http://dx.doi.org/10.1515/biol-2022-0504.

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Abstract Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a significant cause of lifelong physical disability in surviving infants. NTDs are complex diseases caused by multiple etiologies, levels, and mechanisms. Currently, the pathogenesis of NTDs is considered to be associated with both genetic and environmental factors. Here, we aimed to review the research progress on the etiology and mechanism

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Ratajczak, Alicja Ewa, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, and Iwona Krela-Kaźmierczak. "Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?" Nutrients 13, no. 11 (2021): 4036. http://dx.doi.org/10.3390/nu13114036.

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Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the MTHFR gene. The human body is not able to synthesize folic acid; thus, it must be supplemented with diet. The most common consequence of folic acid deficiency is anemia; however, some studies have also demonstrated the correlation between low bone mineral density, hyperhomocysteinemia, and folic acid deficiency. Patients with inflammato

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Dugbaza, Jacinta, and Judy Cunningham. "Estimates of Total Dietary Folic Acid Intake in the Australian Population Following Mandatory Folic Acid Fortification of Bread." Journal of Nutrition and Metabolism 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/492353.

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Mandatory folic acid fortification of wheat flour for making bread was implemented in Australia in September 2009, to improve the dietary folate status of women of child-bearing age, and help reduce the incidence of neural tube defects in the population. This paper presents estimates of folic acid intake in the target population and other subgroups of the Australian population following implementation of the mandatory folic acid fortification standard. In June/July 2010 one hundred samples from seven bread categories were purchased from around the country and individually analysed for the amou

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Li, Shizhao, Lihui Zhi, Yanli Liu, et al. "Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler." British Journal of Nutrition 115, no. 3 (2015): 411–21. http://dx.doi.org/10.1017/s0007114515004511.

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AbstractThis study was conducted to investigate the effect of in ovo feeding (IOF) of folic acid on the folate metabolism, immune function and the involved epigenetic modification of broilers. A total of 400 (Cobb) hatching eggs were randomly divided into four groups (0, 50, 100 and 150 µg injection of folic acid at embryonic age 11 d), and chicks hatched from each treatment were randomly divided into six replicates with 12 broilers/replicate after incubation. The results indicated that, in ovo, 100- and 150-µg folic acid injections improved the hatchability. The average daily gain and feed co

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Kumar, Archana, NirmalyaRoy Moulik, and Suraksha Agrawal. "Folic acid, one-carbon metabolism & childhood cancer." Indian Journal of Medical Research 146, no. 2 (2017): 163. http://dx.doi.org/10.4103/ijmr.ijmr_275_15.

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Nielsen, Karen Brøndum, Niels Tommerup, Brigitte Fariis, and Erik Hippe. "Folic acid metabolism in patient with fragile X." Clinical Genetics 24, no. 3 (2008): 153–55. http://dx.doi.org/10.1111/j.1399-0004.1983.tb02231.x.

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28

Castellanos-Sinco, H. B., C. O. Ramos-Peñafiel, A. Santoyo-Sánchez, et al. "Megaloblastic anaemia: Folic acid and vitamin B12 metabolism." Revista Médica Del Hospital General De México 78, no. 3 (2015): 135–43. http://dx.doi.org/10.1016/j.hgmx.2015.07.001.

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Paul, Raymond T. P., Anne P. McDonnell, and Christopher B. Kelly. "Folic acid: neurochemistry, metabolism and relationship to depression." Human Psychopharmacology: Clinical and Experimental 19, no. 7 (2004): 477–88. http://dx.doi.org/10.1002/hup.614.

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Lewis, Dale P., Don C. Van Dyke, Laurie A. Willhite, Phyllis J. Stumbo, and Mary J. Berg. "Phenytoin-Folic Acid Interaction." Annals of Pharmacotherapy 29, no. 7-8 (1995): 726–35. http://dx.doi.org/10.1177/106002809502907-816.

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Objective: To review information regarding the dual and interdependent drug-nutrient interaction between phenytoin and folic acid and other literature involving phenytoin and folic acid. Data Sources: Information was retrieved from a MEDLINE search of English-language literature conducted from 1983 (time of the last review) to March 1995. Search terms included folic acid, phenytoin, and folic acid deficiency. Additional references were obtained from Current Contents and from the bibliographies of the retrieved references. Study Selection: All human studies examining the effects of phenytoin on

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Virdi, Sapna, Abbey M. McKee, Manogna Nuthi, and Nafisa M. Jadavji. "The Role of One-Carbon Metabolism in Healthy Brain Aging." Nutrients 15, no. 18 (2023): 3891. http://dx.doi.org/10.3390/nu15183891.

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Aging results in more health challenges, including neurodegeneration. Healthy aging is possible through nutrition as well as other lifestyle changes. One-carbon (1C) metabolism is a key metabolic network that integrates nutritional signals with several processes in the human body. Dietary supplementation of 1C components, such as folic acid, vitamin B12, and choline are reported to have beneficial effects on normal and diseased brain function. The aim of this review is to summarize the current clinical studies investigating dietary supplementation of 1C, specifically folic acid, choline, and v

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Cui, Shanshan, Wen Li, Xin Lv, Pengyan Wang, Guowei Huang, and Yuxia Gao. "Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats." Applied Physiology, Nutrition, and Metabolism 42, no. 10 (2017): 1015–22. http://dx.doi.org/10.1139/apnm-2017-0158.

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Atherosclerosis is a chronic disease that can seriously endanger human life. Folic acid supplementation modulates several disorders, including atherosclerosis, via its antiapoptotic and antioxidative properties. This study investigated whether folic acid alleviates atherogenesis by restoring homocysteine levels and antioxidative capacity in atherosclerosis Wistar rats. To this end, 28 Wistar rats were randomly divided into 4 groups (7 rats/group) as follows: (i) wild-type group, fed only the AIN-93 semi-purified rodent diet (folic acid: 2.1 mg/kg); (ii) high-fat + folic acid-deficient group (H

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Weber, Georg F., and M. G. Nair. "Inhibition of the Neutrophil Nrdph Oxidase by Folic Acid and Antagonists of the Folic Acid Metabolism." Immunopharmacology and Immunotoxicology 14, no. 3 (1992): 523–38. http://dx.doi.org/10.3109/08923979209005409.

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Attias, Z., H. Werner, and N. Vaisman. "Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner." Endocrine-Related Cancer 13, no. 2 (2006): 571–81. http://dx.doi.org/10.1677/erc.1.01156.

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The insulin-like growth factor-I receptor (IGF-IR) has an important role in colorectal cancer development and progression. IGF-IR displays a potent anti-apoptotic activity and is overexpressed in primary tumors and colon cancer-derived cell lines. Folic acid, a member of the vitamin B family, is a chemopreventive agent whose deficiency has been linked to an enhanced colon cancer risk. The present study was aimed at testing the hypothesis that part of the modulatory effect of folic acid on malignant transformation may be attributed to its ability to regulate IGF-IR gene expression. Regulation o

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Villa, Paola, Concetta Perri, Rosanna Suriano, et al. "l-Folic Acid Supplementation in Healthy Postmenopausal Women: Effect on Homocysteine and Glycolipid Metabolism." Journal of Clinical Endocrinology & Metabolism 90, no. 8 (2005): 4622–29. http://dx.doi.org/10.1210/jc.2004-1954.

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Context: Hyperhomocysteinemia as well as alterations of glycemic and lipidic metabolism are recognized as risk factors for cardiovascular diseases. Objective: The aim of this study was to examine the effect of l-folic acid supplementation on homocysteine (Hcy) and related thiols, such as cysteine (Cys) and Cys-glycine (Cys-Glyc) pathways and their relationship to glucose, insulin, and lipidic metabolism in normoinsulinemic postmenopausal women. Design: This study was a randomized placebo, not double-blind, trial. Setting: The study was performed in an academic research center. Patients or Othe

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Zhang, Yuhui, Xiaofeng Zhang, Jianjun Chen, Shouchuan Jiang, Yu Han, and Huahua Du. "Maternal Folic Acid Supplementation Improves the Intestinal Health of Offspring Porcine by Promoting the Proliferation and Differentiation of Intestinal Stem Cells." Animals 13, no. 19 (2023): 3092. http://dx.doi.org/10.3390/ani13193092.

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Maternal folic acid intake has important effects on offspring growth and development. The mechanism involved in the renewal of intestinal epithelial cells remains unclear. Thus, this study aimed to investigate the potential effect of maternal folic acid supplementation during gestation and lactation on the structural and functional development of the small intestine in piglet offspring. Twenty-four Duroc sows were assigned to a control group (CON) and a folic-acid-supplemented group (CON + FA, supplemented with 15 mg/kg of folic acid). The results showed that maternal folic acid supplementatio

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Zhang, Huaqi, Li Zhang, Xuenuo Zhao, et al. "Folic Acid Prevents High-Fat Diet-Induced Postpartum Weight Retention in Rats, Which Is Associated with a Reduction in Endoplasmic Reticulum Stress-Mediated Hepatic Lipogenesis." Nutrients 16, no. 24 (2024): 4377. https://doi.org/10.3390/nu16244377.

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Background: Proactively preventing postpartum weight retention (PPWR) is one of the effective intervention strategies to reduce the occurrence of obesity in women. Population studies have shown that serum folate levels are closely related to body weight. The regulation of folic acid on lipid metabolism has been fully confirmed in both in vivo and in vitro studies. For many years, folic acid supplementation has been widely used in periconceptional women due to its role in preventing fetal neural tube defects. However, whether folic acid supplementation prior to and throughout pregnancy exerts p

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McNeil, Christopher J., Susan M. Hay, Garry J. Rucklidge, et al. "Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets." British Journal of Nutrition 99, no. 2 (2008): 262–71. http://dx.doi.org/10.1017/s0007114507798999.

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The importance of folic acid and the methionine cycle in fetal development is well recognised even though the mechanism has not been established. Since the cycle is active in the maternal liver, poor folate status may modify hepatic metabolism. Pregnant rats were fed diets deficient in folic acid (–F) or in three key methyl donors, folic acid, choline and methionine (–FLMLC) and the maternal liver was analysed on day 21 of gestation. Two-dimensional gel electrophoresis of soluble proteins identified differentially abundant proteins, which could be allocated into nine functional groups. Five in

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Brattström, Lars E., Björn L. Hultberg, and Jan Erik Hardebo. "Folic acid responsive postmenopausal homocysteinemia." Metabolism 34, no. 11 (1985): 1073–77. http://dx.doi.org/10.1016/0026-0495(85)90082-4.

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Romero, Steven A., Daniel Gagnon, Amy N. Adams, et al. "Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans." American Journal of Physiology-Heart and Circulatory Physiology 313, no. 3 (2017): H658—H666. http://dx.doi.org/10.1152/ajpheart.00234.2017.

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Skeletal muscle blood flow is attenuated in aged humans performing dynamic exercise, which is due, in part, to impaired local vasodilatory mechanisms. Recent evidence suggests that folic acid improves cutaneous vasodilation during localized and whole body heating through nitric oxide-dependent mechanisms. However, it is unclear whether folic acid improves vasodilation in other vascular beds during conditions of increased metabolism (i.e., exercise). The purpose of this study was to test the hypothesis that folic acid ingestion improves skeletal muscle blood flow in aged adults performing grade

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Devarshi, Prasad, Ryan Grant, Meredith Wilcox, et al. "Absorption of Folic Acid from Different Delivery Forms: A Randomized, Crossover Study." Current Developments in Nutrition 4, Supplement_2 (2020): 970. http://dx.doi.org/10.1093/cdn/nzaa054_042.

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Abstract Objectives Folate, or folic acid, is a water-soluble B vitamin that plays a role in single carbon transfer reactions, which are involved in the synthesis and metabolism of nucleotides and amino acids. It has been established that adequate folic acid intake helps decrease the prevalence of neural tube defects during conception and early pregnancy. The objective of this study was to assess the bioavailability of folic acid from Prenatal Multi Gummies and Folic Acid tablets in women of childbearing age. Methods Eleven healthy, adult, premenopausal women of childbearing age (18–44 years)

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R. Prinz-Langenohl, S. Brämswig, and O. Tobolski. "A study of plasma folate under the influence of [6S]-5-MTHF in women with 677C→T polymorphism of mthfr with different types of inheritance." REPRODUCTIVE ENDOCRINOLOGY, no. 35 (June 21, 2017): 62–66. http://dx.doi.org/10.18370/2309-4117.2017.35.62-66.

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Background and purpose: 5,10-Methylenetetrahydrofolate reductase is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). The 677C→T mutation of 5,10-Methylenetetrahydrofolate reductase reduces the activity of this enzyme. The aim of this study was, first, to compare pharmacokinetic parameters of [6S]-5-MTHF and folic acid in women with the homozygous (TT) and wild-type (CC) 677C→T mutation, and second, to explore genotype differences. The metabolism of [6S]-5-MTHF and folic acid was evaluated by measuring plasma folate derivatives.Experimental approach: Healthy females (TT, n =

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STAM, Frank, Yvo M. SMULDERS, Coen van GULDENER, Cornelis JAKOBS, Coen D. A. STEHOUWER, and Kees de MEER. "Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects." Clinical Science 108, no. 5 (2005): 449–56. http://dx.doi.org/10.1042/cs20040295.

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Folic acid treatment decreases plasma total homocysteine concentrations in healthy subjects, but the effects on homocysteine metabolism are unknown. In the present study, we investigated the effect of 3 weeks of oral treatment with 5 mg of folic acid on one-carbon flux rates in 12 healthy subjects, using in vivo stable isotope methods. In addition, we determined the effect of folic acid on blood concentrations of amino acids which may have regulatory roles in homocysteine metabolism, i.e. homocysteine, AdoMet (S-adenosylmethionine), AdoHcy (S-adenosylhomocysteine), serine and glycine. Primed,

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GUO, YANFANG, GRAEME N. SMITH, SHI WU WEN, and MARK C. WALKER. "FOLATE METABOLISM AND PREECLAMPSIA." Fetal and Maternal Medicine Review 23, no. 2 (2012): 131–55. http://dx.doi.org/10.1017/s096553951200006x.

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Preeclampsia (PE) is a multisystem disorder of human pregnancy, affecting about 6% of all pregnancies worldwide, and is one of the leading causes of maternal and infant morbidity and mortality. Despite decades of research into the pathogenesis of this complex disease, the underlying mechanisms remain unclear. As a result, the options for prevention and management of PE are limited. In recent years, there has been a growing body of evidence suggesting that folate deficiency is associated with PE, and folic acid supplementation may reduce the risk of developing PE in certain populations. Folate

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R., Prinz-Langenohl, Brämswig S., and Tobolski O. "A study of plasma folate under the influence of [6S]-5-MTHF in women with 677C→T polymorphism of mthfr with different types of inheritance." REPRODUCTIVE ENDOCRINOLOGY, no. 35 (June 21, 2017): 62–66. https://doi.org/10.18370/2309-4117.2017.35.62-66.

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Background and purpose: 5,10-Methylenetetrahydrofolate reductase is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). The 677C→T mutation of 5,10-Methylenetetrahydrofolate reductase reduces the activity of this enzyme. The aim of this study was, first, to compare pharmacokinetic parameters of [6S]-5-MTHF and folic acid in women with the homozygous (TT) and wild-type (CC) 677C→T mutation, and second, to explore genotype differences. The metabolism of [6S]-5-MTHF and folic acid was evaluated by measuring plasma folate derivatives. Experimental approach: Healthy female

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Çoban Ramazan, Dilber, Ülker Anadol, A. Destina Yalçın, and A. Süha Yalçın. "Plasma homocysteine and aminothiol levels in idiopathic epilepsy patients receiving antiepileptic drugs." Turkish Journal of Biochemistry 44, no. 5 (2019): 661–66. http://dx.doi.org/10.1515/tjb-2018-0218.

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Abstract Objective Homocysteine is a sulfur containing amino acid that is formed during methionine metabolism. Patients under long-term antiepileptic drug treatment often have hyperhomocysteinemia. These patients have low levels of serum folate, vitamin B12 and vitamin B6, all of which are associated with homocysteine metabolism. We have investigated the effects of valproic acid and new generation antiepileptic drugs (lamotrigine and levetiracetam) on plasma levels of homocysteine and aminothiols as well as serum vitamin B12 and folic acid. Materials and methods Forty-seven idiopathic epilepti

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Huot, Pedro S. P., Anna Ly, Ignatius M. Y. Szeto, et al. "Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring in a sex-specific manner." Applied Physiology, Nutrition, and Metabolism 41, no. 4 (2016): 411–20. http://dx.doi.org/10.1139/apnm-2015-0503.

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Maternal intake of multivitamins or folic acid above the basal dietary requirement alters the growth and metabolic trajectory of rat offspring. We hypothesized that a modest increase in the folic acid content of maternal diets would alter the offspring’s metabolic phenotype, and that these effects could be corrected by matching the folic acid content of the offspring’s diet with that of the maternal diet. Female Sprague–Dawley rats were placed on a control or a 2.5× folic acid-supplemented diet prior to mating and during pregnancy and lactation. At weaning, pups from each maternal diet group w

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Donnellan, Leigh, Bradley S. Simpson, Varinderpal S. Dhillon, Maurizio Costabile, Michael Fenech, and Permal Deo. "Folic acid deficiency increases sensitivity to DNA damage by glucose and methylglyoxal." Mutagenesis 37, no. 1 (2022): 24–33. http://dx.doi.org/10.1093/mutage/geac003.

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Abstract Type 2 diabetes (T2D) is associated with elevated frequencies of micronuclei (MNi) and other DNA damage biomarkers. Interestingly, individuals with T2D are more likely to be deficient in micronutrients (folic acid, pyridoxal-phosphate, cobalamin) that play key roles in one-carbon metabolism and maintaining genomic integrity. Furthermore, it has recently been shown that deficiencies in these nutrients, in particular folic acid leaves cells susceptible to glucose-induced DNA damage. Therefore, we sought to investigate if the B lymphoblastoid WIL2-NS cell line cultured under folic acid-d

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Adan, Abdisamad Mohamed, Mohamed Osman Siyad, Mohamed Said Ahmed, and Mohamed Osman Omar Jeele. "Folic Acid Deficiency in Severe Hypothyroidism: A Case Report and a Review of Literature." Somalia Turkiye Medical Journal (STMJ) 4, no. 1 (2025): 17–21. https://doi.org/10.58322/stmj.v4i1.65.

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Introduction: Folic acid deficiency anemia and hypothyroidism are common health issues with apparent clinical presentations. While the relationship between thyroid dysfunction and dysfunction in folate metabolism has been describing, comprehensive reports on the concurrent of severe hypothyroidism and folic acid deficiency are confined. This case study aims to explain the clinical presentation, diagnostic evaluation, and management of coexistence folic acid deficiency anemia and hypothyroidism, underscoring the significance of prompt diagnosis and intervention. Case Report: A 22-year-old woman

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Mikhelson, Ar A., E. Yu Lebedenko, O. V. Gayda, Al A. Mikhelson, T. E. Feoktistova, and A. M. Mikhelson. "Iron deficiencies in obstetric-gynecologic practice." Russian Journal of Woman and Child Health 5, no. 2 (2022): 129–37. http://dx.doi.org/10.32364/2618-8430-2022-5-2-129-137.

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Deficiency or excess of microelements and vitamins significantly affects the vital activity at each step of human life. This is particularly significant during pregnancy because of immediate and long-term effects on the fetus and newborn. Iron is one of the essential microelements and plays an important role in the mechanisms of biological oxidation. Iron metabolism in the human body is quite complex and impossible without synergy with other metals and vitamins. Iron is most closely related to folic acid and is critical for many vital processes, including embryogenesis. Considering that iron a

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