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Dissertations / Theses on the topic 'Follicular T cells'

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Published: 7 July 2024
Last updated: 31 July 2025

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1

Trüb, Marta. "Follicular T helper cell populations." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20466.

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Humoral immunity provides protection against subsequent infections. Antigen-specific, high-affinity, class-switched antibodies are produced by B cells through rounds of proliferation, B cell receptor rearrangement and selection in the germinal centres (GC). T cells play an essential and indispensable role in this process and in the recent years the term T follicular helper cells (TFH) was coined to describe this cell subset. The aim of my thesis is to investigate whether there is more than one type of T cells within the TFH population and whether it has important functional consequences. First
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2

Sayin, Ismail. "Characterization of human T follicular regulatory cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1560336991188191.

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3

Misiak, Jan. "The interactions of stromal cells and follicular helper T cells resulting in a B-cell supporting, IL4-producing phenotype in the context of follicular lymphoma." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B030.

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Un microenvironnement riche en IL-4 a été mis en évidence dans le lymphome folliculaire (FL). Cette IL-4 impliquée dans la croissance tumorale a été démontrée comme principalement secrétée par les lymphocytes T follicular helper (Tfh). Dans cette étude, nous étudions l’interaction bidirectionnelle entre les cellules fibroblastiques réticulaires (FRC) dont le réseau est augmenté dans le FL et les lymphocytes Tfh par analyse des profils d’expression génique, et co-culture in vitro des lymphocytes Tfh primaires avec des cellules fibroblastiques humaines de type FRC-like. Nous démontrons que les c
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4

Vanderleyden, Ine. "Follicular regulatory T cell migration and differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288422.

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The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through which they exert their suppressive function. At the outset of this work, the major barrier to un
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5

Wang, Changna. "Follicular Dendritic Cells, Resting CD4+ T Cells and Human Immunodeficiency Virus Expression." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2906.

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Many events associated with Human Immunodeficiency Virus (HIV) infection/replication occur in and around the germinal centers (GCs) of secondary lymphoid tissues where follicular dendritic cells (FDCs) reside, suggesting that this microenvironment may contribute unique signaling that is important to viral progression. My research focused on characterizing signaling, both positive and negative, contributed by FDCs that affects HIV infection and replication. Specifically, I determined if FDC signals could induce the expression of latent HIV in T cells and if so, to characterize the signaling pat
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6

Pandey, Shubham. "Identification of Interleukin 4 - CXCL12 supportive loop in follicular lymphoma." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B031/document.

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Le lymphome folliculaire (FL) est le lymphome B indolent le plus fréquent. Outre des altérations géniques récurrentes, le micro-environnement tumoral, et notamment les cellules stromales lymphoides,joue un rôle majeur dans le développement de ce cancer. Cependant, la caractérisation in-situ des cellules stromales lymphoïdes chez l'homme tout comme les facteurs menant à la polarisation du stroma en un stroma protumoral ont été peu étudiés. Dans cette thèse, nous avons montré, que les cellules stromales présentes dans les ganglions et la moelle osseuse envahis des patients atteints de FL surexpr
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7

Kawamoto, Shimpei. "Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches." Kyoto University, 2011. http://hdl.handle.net/2433/142110.

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8

Thomas, Jessica. "T follicular helper cells in health and inflammatory bowel disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/t-follicular-helper-cells-in-health-and-inflammatory-bowel-disease(1c45e306-6a7b-4d84-b02f-e4e1c500dbea).html.

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The intestinal IgA response has features that are different to those of the systemic humoral response, which is dominated by IgG. Although the IgA response, like the IgG response, includes an antigen specific component, it is also associated with polyspecificity and autoimmunity. The profile of intestinal immunoglobulins changes in inflammatory bowel disease (IBD) where there is a disproportionate increase in IgG production and in ulcerative colitis (UC), this includes the production of autoantibodies. In this thesis, two immunoregulatory T cell subsets that could influence the intestinal B ce
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9

Townsend, William Mathew. "A study of CD4+ follicular helper T cells in the follicular lymphoma microenvironment and normal germinal centres." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-cd4-follicular-helper-t-cells-in-the-follicular-lymphoma-microenvironment-and-normal-germinal-centres(744b7c2f-f848-4c41-8fd1-687dc2201f6b).html.

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Follicular lymphoma is a common B cell malignancy which usually follows an indolent course but it is a heterogeneous disease and there are no biomarkers that can accurately predict outcome or prognosis at the time of diagnosis. There is now clear evidence that the microenvironment plays an important role in the pathogenesis of this disease and the composition of the microenvironment has been linked to prognosis with variable results. The biological basis for the influence of the microenvironment and the contribution of individual cell types remain unclear. In this research we focus on CD4+ T c
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10

Rasheed, Mohammed Ata Ur. "Gene signatures and functional analysis of follicular B helper T cells." [S.l.] : [s.n.], 2006. http://www.diss.fu-berlin.de/2006/538/index.html.

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11

Sabir, Suleman Rahman. "Dissecting the role of T-follicular helper cells in experimental atherosclerosis." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7665/.

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12

Wallin, Elizabeth. "The germinal centre reaction and follicular T cells in alloantibody formation." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:e4ecdd13-7c1e-4d4e-8491-8a22857cdb86.

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Kidney transplantation is the optimal treatment for end-stage renal failure, however graft lifespan remains limited, and a major cause of graft loss is chronic, low-grade antibody-mediated damage. Understanding more about how these antibodies are produced, and how immunosuppression affects cells producing them, may allow both prediction of those at risk, and a mechanism for preventing or minimising antibody production, therefore improving graft lifespan. In particular, interest has grown in CD4 T cells known as circulating T follicular helper (cTfh) and T follicular regulatory (cTfr) cells, wh
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13

Pfeilschifter, Janina Marie. "Targeting B non-Hodgkin lymphoma and tumor-supportive follicular helper T cells with anti-CXCR5 CAR T cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23169.

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CAR-T-Zell-Therapie ist eine vielversprechende neuartige Behandlungsform für Patienten mit aggressiven B-Zell Non-Hodgkin-Lymphomen (B-NHL). In dieser Arbeit wurde die anti-CXCR5 CAR-T-Zell-Therapie als Alternative zur anti-CD19 CAR-T-Zell-Therapie für die Behandlung von reifen B-NHLs untersucht. CXCR5 ist ein B-Zell-homing Rezeptor, der von reifen B Zellen und follikulären T-Helferzellen (TFH Zellen) exprimiert wird. TFH Zellen wurden als tumor-unterstützend in chronisch lymphatischer Leukämie (CLL) und im follikulären Lymphom (FL) beschrieben. Dieses Expressionsmuster erlaubt es, auf einziga
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14

Miles, Brodie, Shannon M. Miller, and Elizabeth Connick. "CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection." FRONTIERS MEDIA SA, 2016. http://hdl.handle.net/10150/622733.

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T follicular helper cells (T-FH) are a specialized subset of CD4 T cells that reside in B cell follicles and promote B cell maturation into plasma cells and long-lived memory B cells. During chronic infection prior to the development of AIDS, HIV-1 (HIV) replication is largely concentrated in T-FH. Paradoxically, T-FH numbers are increased in early and midstages of disease, thereby promoting HIV replication and disease progression. Despite increased T-FH numbers, numerous defects in humoral immunity are detected in HIV-infected individuals, including dysregulation of B cell maturation, impaire
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15

Weber, Jan Phillip [Verfasser]. "Generation, Maintenance and Fate of T Follicular Helper Cells / Jan Phillip Weber." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1042940827/34.

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16

Blackburn, Matthew James. "Characterization of a CD4 T cell population enriched in T follicular helper cells in macaques during chronic SIV infection." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12055.

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Thesis (M.A.)--Boston University<br>A preventive vaccine for HIV infection is urgently needed to curb the HIV/AIDS pandemic. To date only one human trial testing the combination of an ALVAC-HIV/gp120 protein strategy (Thai trail) has resulted in some protection from HIV infection. The correlate of protection elicited by this vaccine strategy was non-neutralizing antibodies to the gp120 protein. Nevertheless, the overall efficacy of the Thai trial was limited (31.2%); indicating that more work needs to be performed to ameliorate the Thai trial vaccine efficacy. T Follicular Helper (TFH) cells a
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17

Asrir, Assia. "Caractérisation phénotypique et fonctionnelle des différentes populations de Lymphocytes T CD4 Folliculaires Mémoires." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30084/document.

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Les LT CD4 folliculaires (TFH) forment un lignage distinct de LT contrôlant spécifiquement les lymphocytes B (LB) et la mise en place de la mémoire B. Alors que ces cellules étaient considérées comme des cellules effectrices uniquement, récemment il a été identifié, chez l'Homme et la souris, l'existence de TFH mémoires. Les TFH mémoires en tant que LT CD4 mémoires sont nécessaires, en cas de nouvelle rencontre avec l'antigène (Ag), à la mise en place d'une réponse Anticorps (Ac) rapide, efficace et de forte affinité. En effet, leur présence est corrélée à la génération et le maintien à long t
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18

Pfeilschifter, Janina Marie [Verfasser]. "Targeting B non-Hodgkin lymphoma and tumor-supportive follicular helper T cells with anti-CXCR5 CAR T cells / Janina Marie Pfeilschifter." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1241116989/34.

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19

Alexander, Carla-Maria Alana. "T regulatory cells and the germinal center." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1117.

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Germinal center (GC) reactions are central features of T cell-driven B cell responses, and the site where antibody (Ab) producing cells and memory B cells are generated. Within GCs, a range of complex cellular and molecular events occur which are critical for the generation of high affinity Abs. These processes require exquisite regulation not only to ensure the production of desired Abs, but to minimize unwanted autoreactive or low affinity Abs. To assess whether T regulatory cells (Treg) participate in the control of GC responses, immunized mice were treated with either an anti-glucocorticoi
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20

Le, Thi Kieu Suong. "Caractérisation phénotypique et fonctionnelle des lymphocytes T infiltrants dans les lymphomes B humains." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5006.

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Les lymphomes B sont des cancers du système lymphatique se développant à partir des cellules B. Il devient évident que le développement des cellules B malignes dépend d’interactions avec les cellules immunes dans leur microenvironnement. Nous avons étudié la caractérisation des lymphocytes T intra tumoraux afin de comprendre leur contribution dans la lymphomagenèse et leur potentiel thérapeutique dans les lymphomes B comme le lymphome diffus à grandes cellules B (DLBCL), le lymphome folliculaire (FL) et le lymphome Hodgkinien classique (cHL)Nous avons mis en évidence une différence importante,
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21

Ollerton, Matthew T. "Capacity of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells to Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/7240.

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An important obstacle to a functional cure for HIV/AIDS is the persistence of viral reservoirs found throughout the body in various cells and tissues. Reservoirs can be latently infected cells, or in the case of follicular dendritic cells (FDC), non-infected cells that trap infectious virus on their surface through immune complexes (HIV-IC). Although several strategies have been employed to target and eliminate viral reservoirs, they are short-lived and ineffective. In an attempt to provide a long-term approach, chimeric antigen receptor T (CAR-T) cells were designed to eliminate native HIV on
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22

PODESTA', MANUEL ALFREDO. "STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/951499.

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The interaction of follicular helper T (Tfh) cells with B cells within the germinal center of secondary lymphoid organs is essential for the formation of high affinity antibodies, a key effector mechanism of adaptive immunity. Interleukin (IL)-21 is a proinflammatory cytokine produced by Tfh cells, however the signals that license IL-21 production by these cells during their differentiation are unknown. Here we use fate mapping and reporter strategies to show that, after initial differentiation, Tfh cells transition to an IL-21-expressing Tfh21 stage, which is extrinsically regulated by follic
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23

Abduh, Maisa. "Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS371.

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Les lymphocytes T CD8+ spécifiques de l'antigène sont impliqués dans la réponse immunitaire adaptative et jouent un rôle essentiel dans la protection de l'hôte contre l'infection par des pathogènes intracellulaires. Cette protection de longue durée dépend de la génération de réponses lymphocytaires T CD8+ mémoires, hautement fonctionnelles en termes de fréquence et de fonctionnalité, après réinfection.Après présentation de l'antigène, une cellule T CD8 naïve subit une forte expansion clonale, générant une population hétérogène de cellules activées qui est dominée, au sommet de l'expansion, par
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24

Aoki, Nobuhiro. "Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice." Kyoto University, 2011. http://hdl.handle.net/2433/142096.

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25

CAMPOS, Patrícia Isabel Figueiredo. "Characterization of T follicular helper (Tfh) cells and B cell isotype switching induced by type 1 and type 2 adjuvants." Master's thesis, Instituto de Higiene e Medicina Tropical, 2016. http://hdl.handle.net/10362/20059.

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A principal função dos linfócitos T CD4+ é fornecer apoio a outras células no sentido de gerar uma resposta imunitária eficiente. As interações entre as células T e B são essenciais para a produção de respostas humorais, sendo que foi recentemente demonstrado que as células T foliculares auxiliares (Tfh) desempenham um papel crucial neste processo. Caracteristicamente, expressam o fator de transcrição Bcl-6, o recetor de quimiocinas CXCR5 e o marcador de superfície PD-1. A expressão destes marcadores é única e fundamental para que estas células possam aceder ao folículo de células B, onde orie
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Huber, Johanna Elisabeth [Verfasser], and Dirk [Akademischer Betreuer] Baumjohann. "Human circulating T follicular helper cells during viral infection and autoimmunity / Johanna Elisabeth Huber ; Betreuer: Dirk Baumjohann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1226092527/34.

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27

Miles, Brodie, Shannon M. Miller, Joy M. Folkvord, et al. "Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection." PUBLIC LIBRARY SCIENCE, 2016. http://hdl.handle.net/10150/622413.

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During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles. Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle. Here, we show CXCR5(hi)CD44(hi)CD8 T cells are a regulatory subset differing from conventional CD8 T cells, and constitute the majority of CD8 T cells in the follicle. This subset, CD8 follicular regulatory T cells (CD8 T-FR), expand in chronic SIV infection, exhibit enhanced expression of Tim-3 and IL-10, and express less perforin compared to conventional CD8 T cells. CD8 T-FR modestly limit HIV repl
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28

Gu-Trantien, Chunyan. "Gene expression profiling of CD4+ T cells infiltrating human breast carcinomas identified CXCL13-producing T follicular helper cells associated with tertiary lymphoid structures and better patient outcome." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209474.

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<p>Over the past decade, studies using murine models have led to the demonstration that CD4+ T helper (Th) cells play a critical role in the control of cancer progression. Additional support for their importance comes from the growing body of recent clinical/translational research data demonstrating the importance of tumor-infiltrating T and B lymphocytes in long-term patient survival for various types of cancer, including breast cancer (BC). As the key population coordinating adaptive immune responses, the role(s) played by individual Th subsets in cancer immunity remains largely controversia
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Durand, Mélanie. "Spécialisation fonctionnelle des cellules myéloïdes mononucléaires humaines dans l’induction des réponses T folliculaire helper." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB087/document.

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Les cellules T folliculaires helper (Tfh) jouent un rôle central dans la mise en place de réponses humorales efficaces. En effet, les Tfh participent à la sélection des lymphocytes B permettant le développement de lymphocytes B mémoires et d’anticorps de haute affinité. Les Tfh représentent ainsi une cible prometteuse pour la mise en place de nouvelles stratégies thérapeutiques, notamment pour augmenter l’efficacité de la vaccination. Ainsi, il apparaît crucial de mieux comprendre les étapes menant à leur développement, en particulier chez l’Homme. L’initiation de la polarisation Tfh se déroul
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Gigoux, Mathieu. "The role of inducible costimulator-mediated phosphoinositide 3-kinase activation in the differentiation and function of follicular helper T cells." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121421.

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Antibodies are crucial components of the adaptive immune arsenal against invading pathogens. Production of high-affinity class-switched antibodies relies on follicular helper T (Tfh) cells, a distinct subset of CD4 helper T cells that migrate into B cell follicles and promote B cell differentiation into plasma cells during germinal center (GC) reactions. The CD28-like costimulatory receptor Inducible Costimulator (ICOS) is expressed on the surface of activated T cells and is crucial for the generation of Tfh cells in mice and humans, but the molecular mechanisms remained unknown. ICOS had been
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31

Migliori, Edoardo. "The importance of CD4+ follicular helper T cells and tertiary lymphoid structures in the anti-tumor immune response to breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/258252.

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Breast cancer (BC) is the most common cancer in women. It is a highly heterogeneous disease in terms of histology, therapeutic response and patient outcomes. Early and accurate detection of breast cancer is crucial as the patient prognosis varies greatly depending on the diagnosis of the disease. Patient outcomes have been linked to the presence of tumor infiltrating lymphocytes (TIL) in solid tumors. In human BC, higher TIL infiltration is associated with a better prognosis and also predicts relevant responses to pre-operative chemotherapy. TIL are primarily composed of T cells, albeit around
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32

Rouers, Angéline. "Impact de l’infection par le virus de l’immunodéficience humaine sur les populations de lymphocytes T folliculaires helper et les réponses B mémoires." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066497/document.

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La réponse humorale est altérée lors de l’infection par le virus de l’immunodéficience humaine (VIH). Les lymphocytes T CD4+ folliculaires helper (Tfh) sont impliqués dans la maturation des lymphocytes B (LB) dans les organes lymphoïdes secondaires. Mon travail de thèse s’est articulé autour de deux axes complémentaires visant à étudier les Tfh et les réponses B mémoires lors de l’infection par le VIH. J’ai d’abord étudié les Tfh spléniques lors de la phase chronique de l’infection par le VIH. J’ai mis en évidence une augmentation des populations de Tfh dans les rates de patients VIH+. D’autre
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Trichot, Coline. "Regulation of Human T Helper Cell Diversity : From In Vitro Dendritic Cell-Based Mechanisms to Candidate Biomarkers in Atopic Dermatitis." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS423.

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Le système immunitaire humain est majoritairement commandé par les cellules dendritiques et les lymphocytes T auxiliaires. Lorsque les cellules dendritiques détectent un pathogène, elles vont instruire les lymphocytes T auxiliaires afin qu’ils adoptent le phénotype approprié à la menace rencontrée. Les lymphocytes T auxiliaires peuvent être divisés en plusieurs sous-populations, caractérisées par la production de cytokines spécifiques. Chaque sous-population de lymphocyte T auxiliaire possède des fonctions propres et est impliquée dans l’élimination de pathogènes distincts. Si les réponses des
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34

Ogbe, Ane Theodora. "Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11214.

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The Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system. These transcription factors have reported functions in T cell receptor signaling, differentiation of effector T cell subsets and the development of lupus-like autoimmune diseases. Using CD2-Egr2-/- Egr3-/- mouse model, I investigate the development of inflammation pathology, differentiation of T follicular helper (Tfh) cells and the formation of germinal centers (GC) following viral challenge within these mice. The onset of inflammation pathology in CD2-Egr2-
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35

Jacquemin, Clément. "Modulation de la balance lymphocytaire T régulatrice et effectrice dans deux modèles de maladies auto-immunes." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22050.

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Le respect de l’équilibre entre lymphocytes T effecteurs auto-réactifs et lymphocytes T régulateurs (LTreg) est primordial dans le maintien de la tolérance aux antigènes du soi. Les partenaires cellulaires et les mécanismes moléculaires impliqués dans la rupture de l’équilibre de cette balance ne sont pas ou peu connus dans les maladies auto-immunes. Ainsi, les travaux décrits dans cette thèse portent sur le dérèglement de la balance T effecteurs/ Treg dans deux modèles de maladies auto-immunes chez l’homme: le lupus érythémateux systémique et l’anémie hémolytique auto-immune (AHAI). Nous mont
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36

Nuttens, Charles. "Mécanismes impliqués dans la polarisation des lymphocytes T CD4+ folliculaires et l'initiation de l'immunité muqueuse après immunisation intradermique par un antigène particulaire." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066429/document.

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La nature des cellules dendritiques (DC) engagées lors d'une vaccination conditionne la qualité de la réponse immunitaire adaptative. L'immunisation par la peau est particulièrement efficace car elle cible de nombreuses sous-populations de DC cutanées telles que les cellules de Langerhans (LC). Cependant, les relations entre ces DC et les cellules effectrices associées à la réponse humorale ne sont pas connues. L'objectif de ma thèse est d'identifier les mécanismes cellulaires précoces impliqués dans l'initiation de la réponse humorale, dans un contexte de vaccination intradermique (i.d.) avec
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El, Sayed Rania. "ROLE OF FDCs AND FDC ACTIVATION IN PROMOTING HUMORAL IMMUNITY INCLUDING RESPONSES TO T-DEPENDENT ANTIGENS IN THE ABSENCE OF T CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1927.

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Follicular dendritic cells (FDCs) reside in primary B-cell follicles and in the light zones of germinal centers (GCs) in secondary follicles, where their dendrites interdigitate forming extensive networks intimately interacting with B-cells. In GCs, FDCs can be found at the edges attached to the supporting reticular fibers. They trap and arrange immune complexes (ICs) in vivo and in vitro in a periodic manner with 200–500Å spacing and provide both antigen-specific and non-specific accessory signals to B-cells. FDCs exist in resting and activated states, with two characteristically different ph
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Maho, Maud. "Evaluation des effets des traitements par Rituximab versus corticothérapie seule sur la réponse auto-réactive des patients atteints de pemphigus. First-line Rituximab combined with short-term Prednisone versus Prednisone alone for the treatment of Pemphigus (RITUX 3) : a prospective, multicentre, parallel-group, open-label randomised trial Risk factors for short-term relapse in patients with pemphigus treated by Rituximab as first-line therapy Rituximab and corticosteroid effect on Desmoglein specific B cells and T follicular helper cells in patients with Pemphigus Modifications or the transcriptomic profile of autoreactive B cells from pemphigus patients after treatment with Rituximab or standard corticosteroid regimen Long-term increase of Kcnn4 potassium channel surface expression on B cells in pemphigus patients after Rituximab treatment Rituximab is an effective treatment in patients with Pemphigus Vulgaris and demonstrates a steroid-sparing effect Modifications of the BAFF/BAFF-Receptor axis in patients with pemphigus treated with rituximab versus standard corticosteroids regimen. CD11C+ B cells are mainly memory cells prone to differentiate into antibody-secreting cells." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR132.

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Le pemphigus est une maladie auto-immune spécifique de la peau et des muqueuses provoqué par des auto-anticorps (Ac) spécifiques des desmogléines (Dsg) 1 ou 3. Ces Ac pathogéniques inhibent l'adhésion cellulaire des kératinocytes. Le pemphigus se déclenche par la conjonction d’événements rares impliquant l’émergence puis la coopération de lymphocytes B (LB) et de lymphocytes LT auto-réactifs dans un contexte génétique et environnemental particulier. Jusqu’à présent, la première ligne de traitement du pemphigus était constituée de fortes doses de corticoïdes, qui sont de puissants immunosupress
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39

Gong, Ya-Zhuo. "Role of salivary gland epithelial cells in the differentiation and activation of T lymphocytes in primary Sjögren's syndrome." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ100/document.

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Le syndrome de Sjögren primitif (SJp) est une pathologie auto-immune caractérisée par une sécheresse occulobuccale, un infiltrat lymphocytaire des glandes salivaires, ainsi qu'une production d'auto-anticorps. Les cellules épithéliales salivaires (SGEC) des patients atteints de SSp expriment les molécules impliquées dans les réponses immunitaires et jouent le rôle des cellules présentatrices d’antigènes. Les lymphocytes T folliculaires (LTf) jouent un rôle important en activant les lymphocytes B via la sécrétion d’interleukine (IL)-21. Une augmentation de la proportion de LTf est observée dans
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40

Le, saos-Patrinos Corentin. "Rôle des lymphocytes T CD4+ folliculaires dans la physiopathologie de la leucémie lymphoïde chronique." Electronic Thesis or Diss., Bordeaux, 2022. http://www.theses.fr/2022BORD0093.

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La leucémie lymphoïde chronique (LLC), leucémie la plus fréquente chez l’adulte, est caractérisée par l’accumulation de petits lymphocytes B matures dans la moelle osseuse, les organes lymphoïdes secondaires et le sang périphérique due à une prolifération anormale et à une résistance accrue à l’apoptose des cellules B. La LLC est d’évolution lente et de pronostic variable ; certains patients sont asymptomatiques alors qu’à l’inverse, d’autres présentent une forme agressive de la maladie associée à des complications potentiellement mortelles. Bien que les altérations génétiques jouent un rôle c
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41

Vaineau, Romain. "Impact of IL-1β on Tfh and Tfr lymphocytes during physiological and pathological germinal center reaction". Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS504.

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Les lymphocytes T folliculaires auxiliaires (Tfh) et régulateurs (Tfr) orchestrent la réaction de centre germinatif (GC) en contrôlant la maturation des lymphocytes B. L'équilibre entre ces cellules est crucial pour la production d'anticorps de haute affinité; sa perturbation peut induire l'auto-immunité, mettant en exergue l'importance des mécanismes régulateurs essentiels. L'interleukine-1β (IL-1β), une cytokine pro-inflammatoire connue, attire l'attention. Son rôle précis est bien documenté dans le cadre de l'immunité innée grâce au récepteur agoniste IL-1R1 et au récepteur leurre IL-1R2 qu
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Marschall, Pierre. "Etude de la fonction des cellules dendritiques dans la réponse immunitaire cutanée de type 2." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ044.

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La dermatite atopique (AD) est une des maladies inflammatoires chroniques cutanée les plus fréquentes qui affecte jusqu'à 20% des enfants et 3% des adultes dans le monde. Elle se caractérise par une inflammation chronique de la peau et des réponses immunitaires humorale et de type 2. Mon travail de thèse est d'étudier le rôle des cellules dendritiques (DCs) dans la génération des lymphocytes T et la pathogenèse de l'AD. Dans la partie I, à l'aide de deux modèles murins d'AD, l'un déclenché par la surexpression de TSLP dans la peau induite par l'application topique de MC903 et l'autre par sensi
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Powell, Michael D. "Insights Into the Regulatory Requirements for T Follicular Helper Cell Development." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89085.

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During the course of an immune response, CD4+ T helper cells differentiate into a number of subsets including: T helper 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. The functional diversity of CD4+ T effector cells results in a coordinated, pathogen-specific immune response. For example, the production of IFNγ by TH1 cells is vital for the clearance of intracellular pathogens, while TFH cell engagement with cognate B cells is required for germinal center (GC) formation and the generation of pathogen- and vaccine- induced antibody production. The development of CD4+ subsets
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Renand, Amédée. "La neuropiline 1 et le récepteur alpha à l’IL-2 (CD25) : expression et implication dans l’homéostasie des lymphocytes T chez l’homme dans un contexte normal ou pathologique." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T032/document.

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Des études récentes ont montré une implication de la neuropiline 1 (Nrp1)dans le contrôle de l’activation des lymphocytes T. Son invalidation s’accompagne d’une aggravation de l’encéphalite auto-immune expérimentale (EAE). La sémaphorine 3A (Sema-3A), ligand principal de la Nrp1, semble participer à une boucle autocrine de rétro contrôle négatif de la prolifération des lymphocytes T.Cependant, peu d’études ont été réalisées chez l’homme pour déterminer dans quelle(s) situation(s) la Nrp1 est exprimée par les lymphocytes T. Notre travail aconsisté à étudier l’expression de la Nrp1 par les popul
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Levin, Clément. "Mécanismes moléculaires et cellulaires dans l’induction des réponses T helper folliculaires après vaccination cutanée." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066480/document.

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La vaccination du tissu cutané présente un fort potentiel, car elle permet le ciblage de l’antigène aux populations de cellules dendritiques uniques et spécialisées de la peau, et le recrutement de cellules inflammatoires du sang.Les cellules T helper folliculaires (TFH) jouent un rôle crucial dans l’établissement de la réponse humorale. Cependant, les interactions cellulaires et moléculaires qui gouvernent leur induction dans un contexte de vaccination restent à élucider.Mon projet de thèse a eu pour but de mieux comprendre les mécanismes d’induction des réponses TFH et humorales, par l’étude
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Beurier, Pauline. "Altérations des lymphocytes T follicular helper dans la sclérodermie systémique." Electronic Thesis or Diss., Sorbonne université, 2025. http://www.theses.fr/2025SORUS073.

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Les lymphocytes T follicular helper (TFH) CD4+CXCR5+PD1+ sont une sous-population lymphocytaire essentielle dans l'activation et la différenciation lymphocytaire B ainsi que dans la mise en place des réponses humorales. Ils sécrètent, entre autres, de l'interleukine (IL)-4 et de l'IL-21 leur permettant de remplir leurs fonctions. Une régulation fine des lymphocytes TFH est essentielle au maintien de l'homéostasie du système immunitaire afin de prévenir les réactions contre les antigènes du soi. En ce sens, les lymphocytes T régulateurs (TREG) et T follicular regulatory (TFR) jouent un rôle clé
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Bin, Sofia <1990&gt. "Erythropoietin reduces pathogenic humoral immunity by inhibiting T Follicular Helper cell differentiation and function." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9694/1/TesiPhD_SofiaBin_Final.pdf.

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A large fraction of organ transplant recipients develop anti-donor antibodies (DSA), with accelerated graft loss and increased mortality. We tested the hypothesis that erythropoietin (EPO) reduces DSA formation by inhibiting T follicular helper (TFH) cells. We measured DSA levels, splenic TFH, TFR cells, germinal center (GC), and class switched B cells, in murine models of allogeneic sensitization, allogeneic transplantation and in parent-to-F1 models of graft versus host disease (GVHD). We quantified the same cell subsets and specific antibodies, upon EPO or vehicle treatment, in wild type
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Boyden, Alexander Wiser. "Influenza A virus induces regulated T cell-driven B cell responses." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3432.

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Protection from influenza A virus (IAV) challenge requires switched, high affinity Abs derived from long-lived memory B cells and plasma cells. These subsets are generated in germinal centers (GCs), hallmark structures of T helper cell-driven B cell immunity. A full understanding of the acute and persistent GC B cell reaction following respiratory IAV infection is lacking, as is the characterization of IAV-induced T follicular helper (TFH) cells that support GCs. Additionally, it remains unclear as to whether IAV-induced GC B cells are subject to control by regulatory T cells (Tregs). To addre
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Suhail, Tahir. "A CD153+ CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production." Kyoto University, 2015. http://hdl.handle.net/2433/202671.

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Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.

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