Dissertations / Theses on the topic 'Followup'
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Cappelen, Vendela. "Implant Movement Analysis in theroutine diagnosis of aseptic looseningafter hip arthroplasty, a two year followup." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93323.
Full textCox, Timothy C. "A Followup Study Of Community College Transfer And University Graduates' Career Advancement, Salaries And Professional Achievement In Journalism." Scholarly Commons, 1986. https://scholarlycommons.pacific.edu/uop_etds/3235.
Full textSaputro, Soenarto. "Educational evaluation : a followup study of the graduates of technical/vocational teacher education of FPTK-IKIP Yogyakarta in Indonesia /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu14875876041334.
Full textMaciel, Maria Helena Versiani. "A adesão ao tratamento de portadores de paracoccidioidomicose cutâneo mucosa atendidos em um hospital escola do interior paulista." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-19102007-141628/.
Full textThe chronical conditions can cause physical, emotional and social progressive alterations, requiring in some situations permanent changes in people life style. Paracoccidioidomycosis is a systemic mycosis, that requires a long-term treatment and its higher prevalence is in Latin America with different endemic areas in Brazil. This study aimed to characterize the clients carrie cuataneous mucosal paracoccidioidomycosis and to identify the reasons of non adhesion to clinical therapeutical follow-up. A total of 74 patient file were consulted of adults clients cared and/or interned is a teaching hospital of the interior of São Paulo State, in the period January 2000 through June 2006. The project was approved by the Ethical and Research Commitment of the hospital. Most of the participants was male (86,5%), with average age of 44,5 years old, 67,6% of the cases were interned from one to eight times and in 50,0% of the cases the hospitalization occurred due to recidives and 74,3% took the medicine in a irregular way, there was also the abandonment of the treatment in 54,0%. The nurse as the essencial member of health services can propose individual and collective strategies to the caring, in order to incentivate the client to deal with the changes and in consequence to improve the levels of adhesion to the follow-up.
Sowulewski, Stephen P. "THE EXPERIENCES AND PERCEPTIONS OF BEHAVIORAL FACTORS THAT CONTRIBUTE TO SUCCESSFUL WEIGHT LOSS IN MALE BARIATRIC PATIENTS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4674.
Full textRindzevičius, Vytautas. "Short-term effects of controlled conservation burning." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234965.
Full textGardner, Robert D. "The development of a theoretical model to predict retention, turnover, and attrition of K-12 music teachers in the United States : an analysis of the Schools and staffing survey and Teacher followup survey (1999-2001) /." Digitized version, 2006. http://hdl.handle.net/1802/5828.
Full textTanamati, Liège Franzini. "Audição e inteligibilidade da fala de crianças após 10 anos da cirurgia de implante coclear." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-11052012-133542/.
Full textThe communication skills of prelingually deafened children, underwent cochlear implant (CI) surgery, develop over the years of device use. The aim of this work was to study the performance achieved by teenagers and young adults with at least ten years of IC experience with regard to speech perception and speech intelligibility and, considering the type of hearing loss, duration of deafness, and type of device. Participated of this study, 61 teenagers and young adults prelingually deafened, who received different types of CI, on average at 3 years and 10 months of age. Recognition of two-syllable word list, test Hint and recognition of Hint sentence in quiet and noise were the procedures used to evaluate the hearing performance. The speech intelligibility of the participants was evaluated by two judges, using the writedown intelligibility method and a 5-points intelligibility rating-scale. After 10 years of experience with CI, 53 participants (86,9%) achieved open-set speech recognition. The average results obtained in the two-syllable word list were 49, 4%; in the test Hint in quiet, the average results were 54,7 dB in quiet and 10,7 dB in noise and; the mean percentage of Hint sentences in quiet was 54% and in noise, 33,3%. Regarding the speech intelligibility of the participants, the average write-down intelligibility score was 76,2% and the average rating-scale intelligibility score was 3,3 points. Better speech performances in quiet and in noise were correlated with shorter duration of deafness. Correlation was found between the type of device and: the speech perception in noise and the speech intelligibility. Nucleus 24 and Med-El device users performed better than Nucleus 22 users with regard to speech perception in noise and speech intelligibility. More than 10 years after the CI surgery, 82% of children implanted with the first generation of the electronic device developed speech recognition in noise and 90,1% achieved intelligible speech. Speech perception and speech intelligibility of the participants, both were influenced by duration of deafness and type of electronic device. Considering the contemporary criteria of surgical indication in association with the new speech coding strategies available, promising results were expected for the new generation of children underwent to CI
Coid, Bina. "A long-term follow-up of personality disorders : Maudsley twin series." Thesis, King's College London (University of London), 1997. https://kclpure.kcl.ac.uk/portal/en/theses/a-longterm-followup-of-personality-disorders--maudsley-twin-series(3594b7ec-f6f5-4a80-94c0-cb923dc92c37).html.
Full textLovett, Denise Claire. "Follow the first follower : donations to charity and pro-social behaviour." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/60952/.
Full textHall, Bradley S. "Long-term follow up of rapid palatal expansion followed by edgewise orthodontics :." Oklahoma City : [s.n.], 2008.
Find full textMawhood, Lynn Dianne. "Autism and developmental language disorder implications from a follow-up in early adult life." Thesis, King's College London (University of London), 1995. https://kclpure.kcl.ac.uk/portal/en/theses/autism-and-developmental-language-disorder-implications-from-a-followup-in-early-adult-life(931e504b-c0cd-462f-9417-d12d58a96c34).html.
Full textMallen, Angela. "An exploration of factors affecting goal choice, attrition and attendance at follow-up in an alcohol treatment unit." Thesis, Bangor University, 1995. https://research.bangor.ac.uk/portal/en/theses/an-exploration-of-factors-affecting-goal-choice-attrition-and-attendance-at-followup-in-an-alcohol-treatment-unit(3bea1444-3e12-40e2-91bb-24c6b40785ad).html.
Full textGorman, C. Allen, and Jason S. Gamble. "Leader Behavior and Follower Work Behavior: The Influence of Follower Characteristics." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/415.
Full textLeBreton, Daniel Lawrence. "Leader Influence Behavior, Follower ILTs, and Follower Commitment: A Multilevel Field Investigation." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/27287.
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Ousmane, Sembène, and Lynn Scholtz. "Niiwam, followed by Taaw." Thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/23552.
Full textWang, Lei Wang. "Advanced Line-Follower Robot." Cleveland State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=csu15138819177179.
Full textNyrén, Edvard, and Maria Nyström. "Image follows structure." Thesis, Linköping University, Department of Management and Economics, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2024.
Full textBackground: The business market today is characterized by tough competition amongst the competitors to capture consumers’ interest and money. One marketing tool companies can use to achieve this is the company’s image. The customer buys not only a product, but also the image that the company or the product is associated with. To reach the desired corporate image companies need to be aware of the signals they are sending out and how and what to communicate to the market. They need to look within themselves and their internal factors, since the signals are created within the company.
Purpose: To examine how different structures of organisations can influence a company’s internal image and thereby leave a contribution to the knowledge of a business’ internal image.
Research Method: Empirical studies have been accomplished through interviews with employees on different positions at Nexus. A case study approach was used to give a more complete depiction of the company.
Conclusion: A splinter within an organization can be seen through its image, which affects the external image. Uncertainty in the structure of the organization will also be exposed to the environment, which will lead to a splintered picture of the organization. Two important factors when creating an image are business culture and information/communication. These factors will together generate a united transmission of the company and its values.
Gülstorff, Torben. "Trade follows Hallstein?" Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät I, 2016. http://dx.doi.org/10.18452/17628.
Full textFor decades articles and books have been published on the history of German foreign policy during Cold War. Regardless of whether Europe, Africa, Asia, Oceania, America or the world as a whole, the foreign affairs of the Western Federal Republic of Germany and the Eastern German Democratic Republic have been researched and analysed in context of a broad variety of locations. However, even though the list of publications continues to grow, the topic''s theses–especially its main thesis–do not show much progress. Already at an early stage, a central thesis–a core thesis–came to light, met no resistance and entered history''s and political science''s research canons on German foreign policy. This thesis reads: Inner German issues and the non-solved German question were so powerful, they dominated West and East German foreign affairs nearly right from the start. German foreign policy, that was the so-called Hallstein doctrine, that was the so-called German-German contradiction. And all studies–whether of history or political science, whether designed as a case study or as a global approach–confirm this thesis, use it as an integral part of their work–until today. But be that as it may. This study contradicts this thesis, this ''myth'' of German foreign policy. Instead it argues that neither the Hallstein doctrine nor the German-German contradiction, but national economic and international geostrategic interests dominated German foreign policy and German foreign activities–regarding the FRG, the GDR, and Germany as a whole. To proof this thesis, West and East German activities–of the two states, their economies and their societies–in nine Central African states between 1945 and 1975 are observed and analysed. More than a million file pages out of more than a dozen German archives were read to tackle this task–and shed some refreshing new light on the foreign policies of the two German states during Cold War.
Silva, Magna Maria Pereira da. "Controle da neoplasia maligna do colo de ?tero: a resolutividade na aten??o b?sica." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14758.
Full textCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
A quantitative, descriptive, cross-sectional and retrospective study, using technical procedures of document consultation from secondary sources and health household survey with application form for face to face inter views, with the assent n?.039/2011 from the Ethics Committee of the Federal University of Rio Grande do Norte. The aim of this study was to analyze the cervix cancer control in the area47 of the Health Family Centre Nova Natal II. The cancer cervix is the second most common cancer among women worldwide. In Brazil screening for early detection and treatment of disease has been poorly done and follow-up to reduce mortality has not been executed. From a total of1170women belonging to area 47, who under went screening by the Pap test in the period from 2005 to 2010,was elected a sample of 38 women with positive cervical changes, over 18 years old. The calculation of frequency analysis of socio demographic and clinical and epidemiological selected variables with the results of cervical changes, using the X2 test and taking as significance level of p<0.05 was not statistically significant. The predominant age range was 25 to 64 years (68.9%), most no white women (60.5%), predominantly with primary education (57.9%), most married (68.4%) and housewives (68.4%) with early age of sexual activity (86.8%), the minority smokers (13.2%), with a sexual partner (36.8%). At the time of interview, 42.1% of the women voiced complaint of discharge, while only 2.6% reported bleeding. In relation to the occurrence of STDs (including HPV), 10.5% of women reported being a carrier. The use of oral contraceptives was 32.3% of women, from 2 to 4 years (44.4%). The result of the last screening test performed, showed prevalence of immature squamous metaplasia (55.3%), followed by intraepithelial low- grade lesion (including the cytopathologic HPV effect and cervical intra epithelial neoplasia grade I) (31.6%); intraepithelial high-grade lesion (including cervical intraepithelial neoplasia grade II and III) (7.9%), atypical squamous non neoplastic cells (5.3%). There was no squamous cell carcinoma and adenocarcinoma. Most women received information about the action that should be done after the last screening test result (55.3%), but how to perform follow, most women did not report having done so (55.3%). The follow-up group of women studied, with varying degrees of cervical abnormalities, should only be completed with the discharge by cure, established inconsecutive negative cytology, a goal that is not being achieved in the area 47 of the Health Family Centre of Nova Natal II
Estudo quantitativo realizado por meio de pesquisa descritiva, transversal e retrospectiva, utilizando procedimentos t?cnicos de consulta documental a fontes secund?rias e inqu?rito domiciliar com aplica??o de formul?rio de entrevistas face a face, ap?s parecer favor?vel n? 039/2011 do Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte. O objetivo dessa pesquisa foi analisar a resolutividade do controle da neoplasia maligna do colo de ?tero na ?rea 47 da Unidade de Sa?de da Fam?lia Nova Natal II. A neoplasia maligna do colo de ?tero ? o segundo tipo de c?ncer mais frequente entre as mulheres no mundo. No Brasil o rastreamento para detec??o e tratamento precoces da doen?a tem sido efetuado precariamente e o seguimento, para reduzir a mortalidade, n?o tem sido executado. De um total de 1170 mulheres pertencentes ? ?rea 47, que se submeteram a rastreamento por meio do exame de Papanicolau, no per?odo de 2005 a 2010, elegeu-se uma amostra de 38 mulheres com resultado positivo de altera??es cervicais, maiores de 18 anos. A an?lise do c?lculo da frequ?ncia de vari?veis sociodemogr?ficas e cl?nico-epidemiol?gicas selecionadas com os resultados das altera??es cervicais, utilizando-se o teste de X2 e adotando como n?vel de signific?ncia p<0,05 n?o mostrou signific?ncia estat?stica. A faixa et?ria predominante foi de 25 a 64 anos (68,9%); a maioria parda (60,5%); com escolaridade predominante at? o ensino fundamental (57,9%); a maioria casada ou em conviv?ncia marital (68,4%) e donas de casa (68,4%); com in?cio precoce da atividade sexual (86,8%), a minoria fumante (13,2%), com um parceiro sexual (36,8%). No momento da entrevista, 42,1% das mulheres verbalizou queixa de corrimento, enquanto apenas 2,6% referiu sangramento. Em rela??o ? ocorr?ncia de DSTs (inclusive HPV), 10,5% das mulheres declarou ser portadora. Verbalizaram o uso de contraceptivos orais, 32,3% das mulheres, por 2 a 4 anos (44,4%). Quanto ao resultado do ?ltimo exame preventivo realizado, prevaleceu a metaplasia escamosa imatura (55,3%), seguido de les?o intraepitelial de baixo grau (compreendendo efeito citopatol?gico pelo HPV e neoplasia intra-epitelial cervical grau I) (31,6%); les?o intra-epitelial de alto grau (compreendendo neoplasias intra-epiteliais cervicais de grau II e III) (7,9%); c?lulas at?picas escamosas de significado indeterminado, possivelmente n?o neopl?sicas, (5,3%). N?o foi observado carcinoma de c?lulas escamosas e adenocarcinoma. A maioria das mulheres recebeu informa??es sobre o seguimento que deveria ser realizado ap?s o resultado do ?ltimo exame preventivo (55,3%), mas, quanto a realizar o seguimento, a maior parte das mulheres n?o referiu t?-lo feito (55,3%). O seguimento do grupo de mulheres analisadas, com diferentes graus de altera??es cervicais, somente deveria ser finalizado com a alta por cura, estabelecido em citologias consecutivas negativas, meta que n?o est? sendo atingida na ?rea 47 da Unidade de Sa?de da Fam?lia Nova Natal II
Amgheib, Ali Idris Ali. "How leadership styles and follower characteristics predict follower work outcomes in Libyan organisations." Thesis, Kingston University, 2016. http://eprints.kingston.ac.uk/36706/.
Full textSaltz, Jessica Lynne. "Beyond simple similarity the relationship of leader-follower personality fit with follower satisfaction with the leader and follower commitment to the organization /." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1797.
Full textThesis research directed by: Psychology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Paradorn, Vasin. "An Impact Model for the Industrial Cam-follower System: Simulation and Experiment." Digital WPI, 2007. https://digitalcommons.wpi.edu/etd-theses/1096.
Full textSchollin, Helena, and Sandra Thomsen. "To follow or not to follow. A literature review." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-26971.
Full textBackground: Hypertension is a common disease and is a major contributor to diseases such as stroke, heart failure, coronary artery disease and atherosclerosis. An effective drug treatment for hypertension greatly reduces illness and death from these diseases. More than 50% of patients being treated for hypertension, stops treatment within a year of the diagnosis. Among those who continue their treatment, only half are compliant i.e., taking 80% of their prescribed antihypertensive medications. Objective: The aim of this study was to investigate the factors that influence adherence to medication in patients with the diagnosis hypertension. Method: The method used was a literature review with an approach to content analysis. Ten articles from seven quantitative studies and three qualitative studies, answering the study aim were reviewed regarding scientific quality and were finally included in the literature review. Results: The results showed that the reason for not being adherent to medication could be caused by many different factors, based on patients' attitudes to their illness and medicine, social and economic factors, mental influence and the caregiver's role and actions. Conclusion: To see each patient as a unique person and give individualized care improved adherence to drug treatment. This is an area where more research is needed.
Chae, Seungmook. "Effect of Follower Forces on Aeroelastic Stability of Flexible Structures." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5037.
Full textGoering, Daniel Denton. "The influence of perceived leader-follower role-identity centrality congruence on follower performance and work attitudes." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6427.
Full textHobson, Lauren Verdell. "Follow the Bone." PDXScholar, 2019. https://pdxscholar.library.pdx.edu/open_access_etds/4993.
Full textSimms, Marchelle M. "I Will Follow." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1366475648.
Full textKhalifa, Sh Dayeb Amr. "Beyond Toxic Leaders : Follower-centered Approach." Thesis, Linnéuniversitetet, Institutionen för organisation och entreprenörskap (OE), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-34789.
Full textCharalampidis, Nikolaos. "Novel approaches in voltage-follower design." Thesis, Oxford Brookes University, 2006. http://radar.brookes.ac.uk/radar/items/bad01df9-ee82-88aa-e5c8-2d241fb8a2fc/1.
Full textSeeger, David W. "Follower Perception of Leadership Communication and Leadership Style Significantly Predicting Follower Job Satisfaction Among Ohio Community College Employees." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1577826514284816.
Full textCroke, Sandy. "Alumni follow-up study." Menomonie, WI : University of Wisconsin--Stout, 2004. http://www.uwstout.edu/lib/thesis/2004/2004crokes.pdf.
Full textXystouris, George. "SETI follow-up observations." Thesis, Uppsala universitet, Observationell astrofysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294436.
Full textDasborough, Marie T. "Follower emotional responses to attributions of leadership /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18591.pdf.
Full textSipe, Mina T. "Follower personality, schema structure, and leadership endorsement." College Park, Md. : University of Maryland, 2003. http://hdl.handle.net/1903/254.
Full textThesis research directed by: Dept. of Psychology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Chen, Yuanyan. "Autonomous Unmanned Ground Vehicle (UGV) Follower Design." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470951910.
Full textEvans, Paul Gareth. "The dynamics of the leader follower relationship." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-dynamics-of-the-leader-follower-relationship(4b9e04e4-8cdb-4784-99c0-e55b0530fe06).html.
Full textShirzadegan, Mohammad. "Elastohydrodynamic Lubrication of Cam and Roller Follower." Licentiate thesis, Luleå tekniska universitet, Maskinelement, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-26291.
Full textGodkänd; 2015; 20151005 (mohshi); Nedanstående person kommer att hålla licentiatseminarium för avläggande av teknologie licentiatexamen. Namn: Mohammad Shirzadegan Ämne: Maskinelement/Machine Elements Uppsats: Elastohydrodynamic Lubrication of Cam and Roller Follower Examinator: Biträdande professor Andreas Almqvist, Institutionen för teknikvetenskap och matematik, Avdelning: Maskinelement, Luleå tekniska universitet Diskutant: PhD – Senior Researcher Jonas Ståhl, SKF, Göteborg Tid: Fredag 6 november, 2015 kl 09.00 Plats: E632, Luleå tekniska universitet
Chang, Yanling. "A leader-follower partially observed Markov game." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54407.
Full textLerner, Isaac. "Architecture as discourse : form follows fiction." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61707.
Full textMartinez, Lucinda G. "Charismatic Leadership Perceptions from K-12 Administrators: Phenomena of Follower and Leader Interdependency." ScholarWorks@UNO, 2017. https://scholarworks.uno.edu/td/2424.
Full textOlsson, Emelie. "Det goda ledarskapet : Medarbetares värderingar av positiva ledaregenskaper." Thesis, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-15425.
Full textBoyd, Kathleen Benton-Snead. "Employing an Implicit Task to Measure the Effects of Contextual Constraints on Perceptions of Leadership." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/75151.
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Halverson, Kent C. "Multilevel effects of leader charisma on follower satisfaction." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011346.
Full textTrottier, Tracey. "HOW LEADERSHIP AFFECTS FOLLOWER SATISFACTION: THE FEDERAL CASE." Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3214.
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Health and Public Affairs
Public Affairs: Ph.D.
Scherwin, Vicki Mara. "The overlooked dimension of leadership follower self-interest /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872216381&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textMaritz, Rachel. "Strategy-making approaches followed in South African organisations." Thesis, Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-11102008-140300/.
Full textDiaz, Sílvia de Oliveira. "Pregnancy and newborns disorders followed by urine metabolomics." Doctoral thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13110.
Full textChapter 1 introduces the scope of the work by identifying the clinically relevant prenatal disorders and presently available diagnostic methods. The methodology followed in this work is presented, along with a brief account of the principles of the analytical and statistical tools employed. A thorough description of the state of the art of metabolomics in prenatal research concludes the chapter, highlighting the merit of this novel strategy to identify robust disease biomarkers. The scarce use of maternal and newborn urine in previous reports enlightens the relevance of this work. Chapter 2 presents a description of all the experimental details involved in the work performed, comprising sampling, sample collection and preparation issues, data acquisition protocols and data analysis procedures. The proton Nuclear Magnetic Resonance (NMR) characterization of maternal urine composition in healthy pregnancies is presented in Chapter 3. The urinary metabolic profile characteristic of each pregnancy trimester was defined and a 21-metabolite signature found descriptive of the metabolic adaptations occurring throughout pregnancy. 8 metabolites were found, for the first time to our knowledge, to vary in connection to pregnancy, while known metabolic effects were confirmed. This chapter includes a study of the effects of non-fasting (used in this work) as a possible confounder. Chapter 4 describes the metabolomic study of 2nd trimester maternal urine for the diagnosis of fetal disorders and prediction of later-developing complications. This was achieved by applying a novel variable selection method developed in the context of this work. It was found that fetal malformations (FM) (and, specifically those of the central nervous system, CNS) and chromosomal disorders (CD) (and, specifically, trisomy 21, T21) are accompanied by changes in energy, amino acids, lipids and nucleotides metabolic pathways, with CD causing a further deregulation in sugars metabolism, urea cycle and/or creatinine biosynthesis. Multivariate analysis models´ validation revealed classification rates (CR) of 84% for FM (87%, CNS) and 85% for CD (94%, T21). For later-diagnosed preterm delivery (PTD), preeclampsia (PE) and intrauterine growth restriction (IUGR), it is found that urinary NMR profiles have early predictive value, with CRs ranging from 84% for PTD (11-20 gestational weeks, g.w., prior to diagnosis), 94% for PE (18-24 g.w. pre-diagnosis) and 94% for IUGR (2-22 g.w. pre-diagnosis). This chapter includes results obtained for an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) study of pre-PTD samples and correlation with NMR data. One possible marker was detected, although its identification was not possible. Chapter 5 relates to the NMR metabolomic study of gestational diabetes mellitus (GDM), establishing a potentially predictive urinary metabolic profile for GDM, 2-21 g.w. prior to diagnosis (CR 83%). Furthermore, the NMR spectrum was shown to carry information on individual phenotypes, able to predict future insulin treatment requirement (CR 94%). Chapter 6 describes results that demonstrate the impact of delivery mode (CR 88%) and gender (CR 76%) on newborn urinary profile. It was also found that newborn prematurity, respiratory depression, large for gestational age growth and malformations induce relevant metabolic perturbations (CR 82-92%), as well as maternal conditions, namely GDM (CR 82%) and maternal psychiatric disorders (CR 91%). Finally, the main conclusions of this thesis are presented in Chapter 7, highlighting the value of maternal or newborn urine metabolomics for pregnancy monitoring and disease prediction, towards the development of new early and non-invasive diagnostic methods.
O Capítulo 1 descreve o enquadramento deste trabalho identificando as doenças pré-natais relevantes e os métodos de diagnóstico actualmente disponíveis. É depois apresentada a metodologia seguida, assim como uma breve introdução dos princípios dos métodos analíticos e estatísticos aplicados. O capítulo é concluído com uma descrição do estado da arte na área de metabolómica em investigação pré-natal, identificando o mérito desta inovadora estratégia para a identificação de marcadores robustos de doenças pré-natais. A relevância deste trabalho torna-se clara através do escasso uso de urina materna e do recém-nascido em trabalhos anteriores. O Capítulo 2 descreve os procedimentos experimentais utilizados neste trabalho, incluindo condições de amostragem, recolha e preparação das amostras, protocolos de aquisição e de tratamento dos dados. A caracterização da composição da urina materna, através de espectroscopia de Ressonância Magnética Nuclear (RMN) de protão é apresentada no Capítulo 3. Define-se o perfil metabólico urinário característico para cada trimestre de gravidez, tendo sido encontrado um conjunto de 21 metabolitos descritivo das alterações metabólicas ocorridas ao longo da gravidez. 8 metabolitos foram encontrados a variar com a gravidez, pela primeira vez, tendo sido confirmadas variações metabólicas conhecidas. É ainda estudado o efeito do não-jejum (usado neste trabalho) como possível factor de confusão. O Capítulo 4 apresenta o estudo metabolómico de urina materna do 2º trimestre para o diagnóstico de doenças fetais e previsão de complicações mais tarde desenvolvidas. Este estudo compreende a aplicação de um método de selecção de variáveis desenvolvido no âmbito desta tese. Observou-se que as malformações fetais (e, especificamente, do sistema nervoso central, SNC) e as cromossomopatias (e, especificamente, a trissomia 21, T21) são acompanhadas por alterações nos metabolismos energético, dos aminoácidos, lípidos e nucleótidos, enquanto que as cromossomopatias mostraram ser acompanhadas por uma desregulação adicional dos metabolismos dos açúcares, ciclo da ureia e/ou biossíntese da creatinina. A validação dos modelos multivariados revelou taxas de classificação (CR) de 84% para malformações (87%, SNC) e 85% para CD (94%, T21). Para o parto pré-termo, pré-eclampsia (PE) e restrição de crescimento intrauterino (RCIU) observaram-se perfis que podem ajudar à previsão precoce, com CR 84% para pretermo (11-20 semanas de gestação, g.w. pré-diagnóstico), 94% para PE (18-24 g.w. pré-diagnóstico) e 94% para RCIU (2-22 g.w. pré-diagnóstico). Este capítulo inclui resultados obtidos por cromatografia líquida de ultra eficiência acoplada a espectrometria de massa (UPLC-MS) para pré-pretermo e correlação com os dados de RMN. Um possível composto marcador foi detectado mas a sua identificação não foi possível. O Capítulo 5 descreve o estudo metabolómico por RMN da diabetes mellitus gestacional (DMG), estabelecendo-se um perfil metabólico potencialmente preditivo da doença (CR 83%, 2-21 g.w. pré-diagnóstico). Verificou-se ainda que o espectro de RMN contém informação sobre o fenótipo individual, capaz de prever a necessidade futura de tratamento com insulina (CR 94%). No Capítulo 6 demonstra-se o impacto do tipo de parto (CR 88%) e género do bebé (CR 76%) no perfil da urina do recém-nascido. Verificou-se ainda que a prematuridade, depressão respiratória, crescimento grande para a idade gestacional e malformações induzem perturbações metabólicas relevantes (CR 82-92%), assim como algumas doenças maternas como a DMG (CR 82%) e doenças psiquiátricas (91% CR). Finalmente, no Capítulo 7 apresentam-se as principais conclusões deste trabalho, enfatizando o potencial da metabolómica de urina materna e do bebé para o acompanhamento da gravidez e previsão de doenças, visando o desenvolvimento de novos métodos de diagnóstico precoce e não-invasivo.
Jasim, Wesam M. "Improving leader-follower formation control performance for quadrotors." Thesis, University of Essex, 2016. http://repository.essex.ac.uk/17716/.
Full textDuarte, Daniel José da Silva. "Corporate tax avoidance followed by mergers and acquisitions." Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/13186.
Full textEste trabalho tem como objetivo perceber as alterações ao planeamento fiscal da empresa após uma operação de F&A. Várias características de F&A foram testadas numa amostra que abrange 707 operações Europeias. No geral, os resultados sugerem que não há evidência estatística de alterações no planeamento fiscal da empresa adquirente após uma operação de F&A. No entanto, encontrámos evidência de um maior nível de planeamento fiscal quando as operações são horizontais e quando a empresa-alvo tem resultados operacionais negativos no ano anterior à operação. Os nossos resultados sugerem uma diminuição de cerca de 3% na taxa efetiva de imposto quando a operação é horizontal e uma redução dos impostos pagos, entre 6.2% e 8.6%, se a empresa-alvo apresentou resultados operacionais negativos no ano anterior à operação. Esta redução na taxa efetiva de imposto aumenta para 9% se a operação for simultaneamente horizontal e a empresa-alvo tenha resultados operacionais negativos no ano anterior à operação. Os nossos resultados suportam a perspetiva de que motivos fiscais podem não despoletar uma operação de F&A, no entanto uma significativa poupança fiscal parece verificar-se para determinadas características das F&As.
This paper aims to understand the change in corporate tax avoidance following a M&A deal. Several M&A features were tested in a sample which covers 707 European deals. Overall, results suggest that there is no statistical evidence of changes in corporate tax avoidance following M&A deals. However, we found some evidence of higher level of corporate tax avoidance when the deal is horizontal and when the target company had operating losses the year before deal. Our results suggest a decrease in ETR of about 3% for horizontal mergers and a reduction of effective taxes paid between 6.2% and 8.6% if target had negative pre-tax income pre-deal. This reduction in ETR increases to 9% for horizontal deals, in which the target had a negative pre-tax income one-year before the deal. Our findings support the view that tax motives may not trigger M&A deals, although significant tax savings appear to occur for certain M&A characteristics.
info:eu-repo/semantics/publishedVersion