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1

Aditya, Rusyda Dyah Utari, Chairun Wiedyaningsih, and Susi Ari Kristina. "DEMOGRAPHICS AND FACTOR ASSOCIATED WITH FOOD SUPPLEMENTS USE AMONG YOGYAKARTA POPULATION." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (December 1, 2017): 53. http://dx.doi.org/10.22159/ijpps.2017v9i12.21737.

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Objective: The aim of this study was to explore the prevalence of food supplement use and the association between foods supplement use and sociodemographic factors among Yogyakarta population.Methods: A cross-sectional online questionnaire was developed and validated. A number of 933 participants completed the survey during September-December 2016. A convenience sampling technique was used. The sociodemographic characteristics and use of dietary supplements were collected. Frequency distributions were used to explore the use of food supplement. The relationship between demographic factors and dietary supplement use was conducted using pearson correlation analysis.Results: Food supplement daily use was reported by 63% of participants. A mean number of the supplement was 2.3 (SD 2.1). The advertisement was commonly the source of information about food supplement. Age, sex, monthly income, excercise, and smoking status were associated with food supplement use.Conclusion: Use of food supplements in this population was relatively high reflects that of other countries. Participants were using unreliable source of information of the benefits and risks associated with supplement consumption. Health professionals should account for dietary supplements when assessing medication. Regulating bodies and public health officers need to be aware to ensure safe practices.
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Perlitz, Hanna, Gert B. M. Mensink, Clarissa Lage Barbosa, Almut Richter, Anna-Kristin Brettschneider, Franziska Lehmann, Eleni Patelakis, Melanie Frank, Karoline Heide, and Marjolein Haftenberger. "Use of vitamin and mineral supplements among adolescents living in Germany—Results from EsKiMo II." Nutrients 11, no. 6 (May 28, 2019): 1208. http://dx.doi.org/10.3390/nu11061208.

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Dietary supplements may contribute to nutrient intake; however, actual data on dietary supplement use among adolescents living in Germany are rare. The aim of this analysis was to describe the current use of dietary supplements, its determinants, and reasons of use. Changes in supplement use over time were evaluated by comparing the results with those from EsKiMo I (2006). Data from the Eating Study as a KiGGS Module EsKiMo II (2015–2017) were used to analyze supplement intake according to sociodemographic, health characteristics, and physical exercise behavior of 12–17-year-olds (n = 1356). Supplement use during the past four weeks was assessed by a standardized computer assisted personal interview. Multivariable logistic regression was used to identify the association between supplement use and its determinants. Between 2015–2017, 16.4% (95%-CI: 13.0–19.7%) of the adolescents used dietary supplements, and its use decreased with lower levels of physical exercise and overweight. Most supplement users used only one supplement, often containing both vitamins and minerals. The most frequently supplemented nutrients were vitamin C and magnesium. The main reported reason to use supplements was ‘to improve health’. Prevalence of supplement use was slightly lower in 2015-2017 than in 2006 (18.5%; 95%-CI: 15.8–21.2%). The results underline the importance of including nutrient intake through dietary supplements in nutrition surveys.
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Németh, Nikolett. "Factors influencing functional food and food supplement consumption." Review on Agriculture and Rural Development 6, no. 1-2 (July 18, 2018): 44–49. http://dx.doi.org/10.14232/rard.2017.1-2.44-49.

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Functional foods and food supplements are two of the major classes of nutraceuticals or food-related products that have health benefits, such as improving health and prevention and treatment of disease. The aim of this present study is to introduce the main factors influencing functional food consumptions as well as food supplement consumption, searching for the answers to the following research questions: (1) What factors affect functional food and food supplement consumption and to what extent? (2) What is the most authentic source of information in customers’ decision making? Results of secondary and primary researches suggest that the most important factors in decision making are: experience in earlier consumption, nutrients, quality and price. Food supplements are complex products and therefore, it is difficult for consumers to check the quality of these products at point of purchase; thus food-safety is a major issue for customers when buying food supplements. It can also be concluded that the availability and reliability of the source of information can greatly determine customer’s decision making. The most authentic source of information according to customers’ opinion were the following: health care professionals, sales staff and health-related articles. These variables should be taken into account for marketers and businesses when considering product development or improving communication on nutritional and health benefits of functional food and food supplements.
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Lin, Po-Cheng, Tzyy-Wen Chiou, Po-Yen Liu, Shee-Ping Chen, Hsin-I. Wang, Pi-Chun Huang, Shinn-Zong Lin, and Horng-Jyh Harn. "Food Supplement 20070721-GX May Increase CD34+Stem Cells and Telomerase Activity." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/498051.

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Few rejuvenation and antiaging markers are used to evaluate food supplements. We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract. Samples were evaluated for CD34+cells, insulin-like growth factor 1 (IGF1), and telomerase activity, which are all markers related to aging. To control the quality of this food supplement, five active components were monitored. In total, we examined 44 individuals who took the food supplement from 1.2 months to 23 months; the average number of CD34+cells was almost 6-fold higher in the experimental group compared with the control group. Food supplement intake did not change serum IGF1 levels significantly. Finally, the average telomerase activity was 30% higher in the subjects taking this food supplement. In summary, our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging.
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Patel, Khushali, Utsav Patel, Khushboo Vaghela, Niranjan Kanki, Maitreyi Zaveri, and Vinit Movaliya. "Comparisons of registration requirements of Nutraceuticals in Philippines, Tanzania, Cambodia and India." International Journal of Drug Regulatory Affairs 10, no. 4 (December 15, 2022): 18–23. http://dx.doi.org/10.22270/ijdra.v10i4.546.

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"Nutraceuticals" are the combination of Nutrition and pharmaceutical. The term Nutraceutical was given by Dr. Stephen in 1989. A dietary supplement is a product taken by mouth that contains a dietary ingredient (Vitamins, Minerals, Herbs, Amino acids etc.) Numerous definitions and nomenclature for dietary supplements exist worldwide. In India Food Safety and Standards authority (FSSA), defines Nutraceuticals as "foods for special dietary uses or functional foods or health supplements". In Philippines Nutraceuticals are known as food supplement & dilatory supplement. In Sudan, Nutraceuticals are known as dietary supplement & health product .In Cambodia Nutraceuticals are known as health supplement product. Every country has their own guidelines, regulatory requirements which deal with regulatory registration procedures of Nutraceuticals. In order to enter the Indian Nutraceutical market, some of the very important areas of focus include product evaluation, actual product analysis, procuring licenses and developing India specific health and label claims.
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Payne, Martha E., Douglas R. McQuoid, David C. Steffens, and John J. B. Anderson. "Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study." British Journal of Nutrition 112, no. 2 (May 1, 2014): 220–27. http://dx.doi.org/10.1017/s0007114514000828.

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Recent studies have implicated Ca supplements in vascular risk elevation, and therefore these supplements may also be associated with the occurrence of brain lesions (or hyperintensities) in older adults. These lesions represent damage to brain tissue that is caused by ischaemia. In the present cross-sectional clinical observational study, the association between Ca-containing dietary supplement use and lesion volumes was investigated in a sample of 227 older adults (60 years and above). Food and supplemental Ca intakes were assessed with the Block 1998 FFQ; participants with supplemental Ca intake above zero were categorised as supplement users. Lesion volumes were determined from cranial MRI (1·5 tesla) scans using a semi-automated technique; volumes were log-transformed because they were non-normal. ANCOVA models revealed that supplement users had greater lesion volumes than non-users, even after controlling for food Ca intake, age, sex, race, years of education, energy intake, depression and hypertension (Ca supplement use: β = 0·34, se 0·10, F1,217= 10·98, P= 0·0011). The influence of supplemental Ca use on lesion volume was of a magnitude similar to that of the influence of hypertension, a well-established risk factor for lesions. Among the supplement users, the amount of supplemental Ca was not associated with lesion volume (β = − 0·000035, se 0·00 015, F1,139= 0·06, P= 0·81). The present study demonstrates that the use of Ca-containing dietary supplements, even low-dose supplements, by older adults may be associated with greater lesion volumes. Evaluation of randomised controlled trials is warranted to determine whether this relationship is a causal one.
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7

de Jong, Nynke, Marga C. Ocké, Hester A. C. Branderhorst, and Roland Friele. "Demographic and lifestyle characteristics of functional food consumers and dietary supplement users." British Journal of Nutrition 89, no. 2 (February 2003): 273–81. http://dx.doi.org/10.1079/bjn2002772.

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Functional foods and/or supplements may be used in the context of a healthy lifestyle or as a means to compensate for an unhealthy lifestyle. Adverse long-term and/or cumulative effects of functional food or supplement intake are of public health concern; it is therefore important to identify functional food and supplement users. The present study compared Dutch functional food and supplement consumers with non-consumers with regard to demographic and lifestyle factors. The consumption of the most common functional foods and supplements in 2000 was studied (yoghurt with extra lactic acid bacteria, cholesterol-lowering margarine, lemonade and sweets with extra vitamins and minerals, milk and margarine with extra Ca, Ca tablets, multivitamin and mineral supplements, and Echinacea supplements). Data were obtained from self-administered questionnaires filled in by a consumer panel, aged 19–91 years (response rate 76 %, n 1183), representative of the Dutch population. The number of daily consumers of functional foods or supplements appeared to be relatively low (daily use of multivitamin and mineral supplements, 20 %; all other products, 3–9 %). Explanatory variables depended on the type of product; but gender, age, education, and vegetable intake were significant factors in the logistic regression model. Consumption of cholesterol-lowering margarines was more likely to be reported by individuals with a poorer subjective health (odds ratio 2·62 (95 % CI 1·15, 6·05)) and by smokers (odds ratio 2·93 (95 % CI 1·34, 6·40)). In conclusion, determinants of functional food or supplement use depended on the type of product, so generalisation of consumer characteristics over different foods is not legitimate. In addition to research on lifestyle factors, surveys about consumers' attitudes, norms and knowledge regarding functional foods in relation to actual dietary patterns and health risk profiles are necessary.
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Bensa, Maja, Irena Vovk, and Vesna Glavnik. "Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers." Nutrients 15, no. 2 (January 16, 2023): 474. http://dx.doi.org/10.3390/nu15020474.

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The food supplement market is growing as many consumers wish to complement their nutrient intake. Despite all the regulations in place to ensure food supplements safety, there are still many cases of irregularities reported especially connected to internet sales. Twenty resveratrol food supplement products sold on the Slovenian market were evaluated on their compliance of declared vs. determined resveratrol content, as well as the compliance of labels with the European Union (EU) and Slovenian regulatory requirements. Both the ingredient contents and food information are important parts of food safety. Analyses of 20 food supplements performed using high-performance thin-layer chromatography (HPTLC) coupled with densitometry showed that 95% of products had contents different from what was declared and 55% of products contained higher contents than declared. In 25% of the products the determined content per unit exceeded the maximum level (150 mg/day) specified in EU novel food conditions for food supplement with trans-resveratrol. Evaluation of the 20 food supplement labels included mandatory and voluntary food information, food supplement information, novel food information, health claims and nutrition claims. Most labels contained the necessary information, but multiple errors were observed ranging from typos to misleading practices. From a food safety perspective there is still a lot of improvement needed in the field of food supplements.
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Koivuniemi, Ella, Kathryn Hart, Natalia Mazanowska, Stefania Ruggeri, Bernadette Egan, Laura Censi, Romana Roccaldo, et al. "Food Supplement Use Differs from the Recommendations in Pregnant Women: A Multinational Survey." Nutrients 14, no. 14 (July 15, 2022): 2909. http://dx.doi.org/10.3390/nu14142909.

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The aim was to investigate, among pregnant women, (1) the use of food supplements and (2) the awareness of food supplement recommendations and beliefs about food supplement use in four European countries: Finland, Italy, Poland, and the United Kingdom. The participants (n = 1804) completed an online questionnaire with predefined statements. Daily intakes of vitamins and minerals were calculated using uploaded pictures or weblinks of the supplement packages. Country differences were assessed. Most participants (91%) used at least one food supplement during pregnancy. A prenatal multivitamin was the most commonly used supplement type (84% of the users), and 75% of the participants thought consumption of multivitamin is recommended. Of the participants, 81% knew that folic acid is recommended during pregnancy while 58% knew the recommendation for vitamin D. In 19% of the supplement users, the daily safe upper intake limit of at least one nutrient was exceeded. Nevertheless, most participants agreed that they knew which supplements (91%) and doses of supplements (87%) needed to be used during pregnancy. To conclude, the majority of the participants used food supplements, but lower proportions knew and adhered to the recommended intakes. Between-country differences were observed in the use and knowledge of and beliefs regarding supplements. The results suggest a need for assessment and monitoring of supplement use in antenatal care to ensure appropriate use.
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10

Hennessy-Priest, Kathleen, Jill Mustard, Heather Keller, Lee Rysdale, Joanne Beyers, Richard Goy, and Janis Randall Simpson. "Folic acid food fortification prevents inadequate folate intake among preschoolers from Ontario." Public Health Nutrition 12, no. 9 (September 2009): 1548–55. http://dx.doi.org/10.1017/s1368980008004667.

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AbstractObjectiveFolic acid food fortification has successfully reduced neural tube defect-affected pregnancies across Canada. The effect of this uncontrolled public health intervention on folate intake among Canadian children is, however, unknown. Our objectives were to determine folic acid intake from food fortification and whether fortification promoted adequate folate intakes, and to describe folic acid-fortified food usage among Ontario preschoolers.DesignCross-sectional data were used from the NutriSTEP™ validation project with preschoolers recruited using convenience sampling. Mean daily total folate and folic acid intakes were estimated from 3 d food records, which included multivitamin supplement use. Comparisons were made to Dietary Reference Intakes, accounting for and excluding fortificant folic acid, to determine the prevalence of inadequate and excessive intakes.SettingCanada.SubjectsTwo hundred and fifty-four preschoolers (aged 3–5 years).ResultsAll participants (130 girls, 124 boys) ate folic acid-fortified foods and 30 % (n76) used folic acid-containing supplements. Mean (se) fortificant folic acid intake was 83 (2) μg/d, which contributed 30 % and 50 % to total folate intake for supplement users and non-users, respectively. The prevalence of total folate intakes below the Estimated Average Requirement was <1 %; however, excluding fortificant folic acid, the prevalence was 32 %, 54 % and 47 % for 3-, 4- and 5-year-olds, respectively. The overall prevalence of folic acid (fortificant and supplemental) intakes above the Tolerable Upper Intake Level was 2 % (7 % among supplement users).ConclusionsFolic acid food fortification promotes dietary folate adequacy and did not appear to result in excessive folic acid intake unless folic acid-containing supplements were consumed.
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Vatanparast, Hassan, Naorin Islam, Rashmi Prakash Patil, Mojtaba Shafiee, and Susan J. Whiting. "Calcium Intake from Food and Supplemental Sources Decreased in the Canadian Population from 2004 to 2015." Journal of Nutrition 150, no. 4 (December 31, 2019): 833–41. http://dx.doi.org/10.1093/jn/nxz318.

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ABSTRACT Background In light of the publications (2008–2014) linking calcium intake, mainly from supplements, to the elevated risk of cardiovascular events, there is a need to determine if there have been any changes in usual intakes of calcium among Canadians. Objective We aimed to examine changes in dietary and total usual intake of calcium among Canadians aged ≥1 y over the period 2004–2015. Methods We used nutrition data from 2 nationally representative surveys conducted in 2004 and 2015 (CCHS 2004 Cycle 2.2 and CCHS-Nutrition 2015). This study included all the Canadians across 10 provinces, and the analyses were performed across different age/sex groups. We used the National Cancer Institute (NCI) method to estimate the usual intake of calcium and the prevalence of calcium inadequacy. Multiple logistic regression was performed to assess the relation between supplement uses and sociodemographic variables. Results From 2004 to 2015, the usual intake of calcium from food sources significantly decreased in calcium supplement nonusers (from 872 ± 18.2 mg/d to 754 ± 18.0 mg/d), but not in calcium supplement users. The contribution of calcium from the Milk and alternatives food group significantly decreased by 7.5% and 6.1% in calcium supplement users and nonusers, respectively. The prevalence of calcium supplement use significantly decreased from 2004 to 2015 in the Canadian population, from 27.5% to 22.0%. During this time, the percentage contribution of calcium from supplemental sources significantly decreased among Canadians, especially women. The prevalence of calcium inadequacy increased from 58.0% to 68.0% in supplement nonusers; however, among users of calcium supplements, the prevalence of calcium inadequacy remained at ∼31%. Conclusions Calcium intake from both food and supplemental sources decreased in the Canadian population over an 11-y period, which must be addressed by policy-makers in their efforts to decrease the high prevalence of calcium inadequacy.
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Sood, Mousmee, and D. Sharada. "Iron food supplement." Indian Journal of Pediatrics 69, no. 11 (November 2002): 943–46. http://dx.doi.org/10.1007/bf02726008.

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Zeltwanger, Joshua M., Allison M. Meyer, Eric Bailey, Abe Scheaffer, Kevin Meng, and Derek Brake. "395 Effects of supplemental protein and yeast on fermentation of low quality forage in single-flow continuous culture fermenters." Journal of Animal Science 97, Supplement_3 (December 2019): 161–62. http://dx.doi.org/10.1093/jas/skz258.332.

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Abstract Various anecdotes suggest the combination of supplemental protein and yeast improve utilization of low-quality forage. Two studies were conducted to evaluate effects of a commercially available supplement containing protein and yeast on fermentation in single-flow continuous culture fermenters. In Exp. 1, Bermuda grass with no supplement (NCON1), dried distillers grains (PCON1), and two commercially available supplements Diamond V XP (DV1) or SweetPro 16 (SP1) were compared. In Exp. 2, K31 tall fescue with no supplement (NCON2), supplemental dried distillers grains (PCON2), and two commercially available supplements Diamond V XP (DV2) or SweetPro 16 (SP2) were compared. Twenty-four single flow fermenters (1470mL) were randomly assigned to treatments and fed twice daily for 8 d, 5 d of adaptation and 3 d of collection. In both experiments, digestibility of DM, OM, NDF, and ADF were not influenced by supplementation regardless of source (P &gt; 0.10). In Exp. 1, NH3-N concentration increased (P &lt; 0.01) for DV1 over both NCON1 and PCON1 and was greatest for SP1 (P &lt; 0.01). Greater amounts of NH3-N and microbial N were recovered from fermenter overflow when SP1 was supplemented (P &lt; 0.01). Crude protein (CP) degradation was also greatest for SP1; however, when supplement was included, regardless of source, CP degradation was increased over NCON1. Acetate, propionate, butyrate, and total VFA levels were similar (P &gt; 0.10) amongst NCON1, PCON1, and DV1 and greatest when SP1 was supplemented. In Exp. 2, fermenter NH3-N concentration was greatest for SP2 (P &lt; 0.01) and similar amongst NCON2, PCON2, and DV2 (P &gt; 0.01). No differences were detected (P &gt; 0.10) between treatments with respects to CP degradation. Total VFA concentrations increased over time regardless of treatment during the second study.
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Kiely, M., A. Flynn, KE Harrington, PJ Robson, N. O'Connor, EM Hannon, MM O'Brien, S. Bell, and JJ Strain. "The efficacy and safety of nutritional supplement use in a representative sample of adults in the North/South Ireland Food Consumption Survey." Public Health Nutrition 4, no. 5a (October 2001): 1089–97. http://dx.doi.org/10.1079/phn2001190.

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AbstractObjectiveTo describe the current use of nutritional supplements and their contribution to micronutrient intakes in a representative sample of Irish adults, to evaluate the impact of supplement use on the adequacy of micronutrient intakes and to assess the risk to supplement users of exceeding tolerable upper intake levels (UL).Study design and subjectsFood intake data were collected in 1379 (662 male and 717 female) randomly selected Irish adults aged 18 to 64 years using a 7-day food diary. The current use of nutritional supplements was assessed using a selfadministered questionnaire and respondents entered each supplement as it was consumed into the food diary.ResultsTwenty-three per cent of respondents regularly used nutritional supplements. Twice as many women used supplements as men. The intakes of micronutrients were significantly higher (P < 0.001) in supplement users than in non-users. Micronutrient intakes from food sources were similar in male users and non-users of supplements, but were significantly higher (P < 0.01) in female users, by 3 to 13%, for Fe, Mg, Mn, vitamins C and E and niacin than in non-users. The percentage of female users between 18 and 50 years who had mean Fe intakes below the average requirement (AR) (10 mg) decreased from 50 to 25 when the contribution from supplements was included. The use of supplements reduced the percentage of men who had mean intakes below the AR for Zn from 19 to 13, for riboflavin from 14 to 6 and for vitamin A from 20 to 5, and reduced the percentage of women with intakes below the AR for Ca from 23 to 16 and for riboflavin from 23 to 14. Twenty-one women out of 80 aged between 18 and 50 years, who consumed supplemental folate, achieved the intake of 600 |xg recommended to prevent neural tube defects. Twenty-two per cent of the women who took iron and 15% of the women who took vitamin B$ in supplemental form had mean daily intakes that exceeded that UL for these nutrients. Supplement users did not exceed the UL for the other micronutrients.ConclusionsSupplementation appears to be beneficial in promoting adequate intakes of some micronutrients, particularly Fe and folate in women aged 18–50 years and vitamin A in men. There appears to be little risk to supplement users of experiencing adverse side effects due to excessive intakes of micronutrients.
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Douglass, Deirdre, Thea Palmer Zimmerman, Viji Narayana, Amy Miller, Beth Mittl, Tara Lynn Paul, Tom Nicholson, Lauren O'Connor, Kirsten Herrick, and Christie Kaefer. "Development of a Tool for Researchers to Specify New Foods to Be Included in the Automated Self-Administered 24-Hour (ASA24) Dietary Assessment Tool." Current Developments in Nutrition 5, Supplement_2 (June 2021): 872. http://dx.doi.org/10.1093/cdn/nzab048_007.

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Abstract Objectives To develop a tool for researchers to augment the ASA24 database and include novel foods, beverages, and supplements for use in their study. Methods ASA24 uses nutrient values for foods and beverages from USDA's Food and Nutrient Database for Dietary Studies (FNDDS) and supplement values from the National Health and Nutrition Examination Survey Dietary Supplement Database (NHANES DSD). Novel items, such as medical food products, regional or international foods, and proprietary supplement blends may not be present in FNDDS and NHANES DSD, causing researchers to decide not to use ASA24. The ASA24 software engineering and dietary assessment teams analyzed system components including the hierarchal structured database and software code to determine how researcher-provided data for novel items could be incrementally integrated into the complex, “big data” system. The staff evaluated several approaches and technologies to allow researchers to define specific foods, beverages, and supplements against a set of defined evaluation criteria that addressed usability and technical requirements. Results The ASA24 new foods tool is an Excel workbook comprised of 19 worksheets. Excel macros validate data and facilitate navigation through the workbook. The worksheets are comprised of instructions, data entry templates, completed data entry templates for example purposes, and reference data. Researchers specify food, beverage, and supplement terms, portion amount probes and associated images, nutrient and Food Pattern Equivalents Database values, allowing the novel item to be added to the ASA24 system, and ultimately available to respondents using ASA24 to report dietary intake. The tool has undergone multiple rounds of usability testing and refinements to address issues. The integration process includes the maintenance of a master copy of foods, beverages, and supplements that will be available to researchers interested in adding these items to their own studies. Conclusions The ASA24 new foods tool provides researchers with a cost-effective means to add novel foods, beverages, and supplements to their study. This tool can expand the utility of ASA24 to previously understudied groups. Funding Sources This project has been funded in whole or in part by the NIH.
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Nicholson, J. W. G., E. Charmley, and R. S. Bush. "The effect of supplemental protein source on ammonia levels in rumen fluid and blood and intake of alfalfa silage by beef cattle." Canadian Journal of Animal Science 72, no. 4 (December 1, 1992): 853–62. http://dx.doi.org/10.4141/cjas92-097.

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Growing beef cattle fed legume silage were supplemented with urea, soybean meal, fishmeal or a barley-based control in two experiments. In the first experiment, the concentrates were fed before the silage and in the second the silage and concentrates were mixed at feeding. In exp. 1 there were no significant (P > 0.05) effects of CP supplement on feed intake, weight gains or feed efficiency, although animals fed fishmeal gained the most and those fed urea the least. Rumen fluid ammonia N (RFNH3-N) increased more after feeding urea and soybean meal than the control or fishmeal supplements. Blood urea N (BUN) levels changed in parallel with RFNH3-N levels but the magnitude of change was reduced to about half. Blood ammonia N (BNH3-N) levels showed statistically significant changes only with the urea supplement. Cattle fed urea took longer to consume their supplement than those fed the other supplements. In exp. 2 there was no effect of supplement on gains or feed conversion. Animals fed the control supplement consumed more dry matter than those fed fishmeal (P < 0.05). Cattle fed the control supplement had lower RFNH3-N and BUN than those fed the other supplements (P < 0.01) but differences among the sources of CP were small. The urea supplement resulted in a higher BNH3-N than the control or fishmeal supplements (P < 0.05). There was no apparent effect of treatment on blood glucose level in either experiment. It was concluded that cattle adjust their daily eating pattern to maintain BNH3-N levels within physiological limits; that intake of silage dry matter is limited by level of non-protein N and rumen degradable protein; and that provision of bypass protein can improve efficiency of feed conversion of high-silage diets even when depressing feed intake. Key words: Alfalfa, silage, protein supplement, nitrogen, intake
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Santos, Ronald Matos dos, Rogério De Paula Lana, and César Roberto Viana Teixeira. "Performance of Holstein-Gyr crossbred heifers on pasture of Brachiaria decumbens supplemented with multiple supplement or proteined salt." Acta Scientiarum. Animal Sciences 39, no. 4 (September 22, 2017): 371. http://dx.doi.org/10.4025/actascianimsci.v39i4.36013.

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This study aimed to evaluate the performance, efficiency and economic viability of different supplements for dairy heifers on Brachiaria decumbens pasture. Twelve heifers with 186 ± 30.5 kg average weight were divided in three groups of four animals. The treatments were mineral salt ad libitum; 0.4 kg animal-1 day-1 proteined salt and 1.0 kg animal-1 day-1 multiple supplement. The experimental design was randomized blocks, with the contrasts considered significant at 5% probability. There was greater (p < 0.05) body weight and higher daily weight gain in animals supplemented with proteined salt or multiple supplement, compared to supplemented with mineral salt. There was no difference (p > 0.05) in any of the performance parameters between proteined salt and multiple supplement. The use efficiency was 1.31 and 0.61 for proteined salt and multiple supplement, respectively. The cost per kg weight gain in treatments with mineral salt, proteined salt and multiple supplement was R$ 0.67, R$ 0.68 and R$ 1.25, respectively. The use of proteined salt or multiple supplement provides superior performance than mineral salt in crossbred heifers. However, the proteined salt has higher utilization efficiency and economic advantage.
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Agarwal, Megha, Puja K. Mehta, James H. Dwyer, Kathleen M. Dwyer, Anne M. Shircore, Cheryl K. Nordstrom, Ping Sun, Maura Paul-Labrador, Yuching Yang, and C. Noel Bairey Merz. "Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study." Open Cardiovascular Medicine Journal 6, no. 1 (September 7, 2012): 113–21. http://dx.doi.org/10.2174/1874192401206010113.

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Objective:To determine the relationship of vitamin c intake from supplements vs food on early atherosclerosis detected by carotid intima media thickness (IMT).Background:Oxidative stress and endothelial dysfunction play a critical role in the pathogenesis of atherosclerosis. Dietary vitamin C appears to have anti-oxidant properties and beneficial relations to endothelial function, yet vitamin C taken as a vitamin supplement does not appear to protect from cardiovascular events. The impact of vitamin c intake from supplements vs food on progression of atherosclerosis is unknown.Methods:We examined 3-year progression of carotid IMT in a randomly sampled cohort of 573 healthy women and men aged 40-60 years. Progression of carotid IMT was determined bilaterally with B-mode ultrasound at 3 examinations (1.5-year intervals). Intake of dietary vitamin C was measured by six, 24-hour recall interviews. Intake of vitamin C from vitamin supplements was measured by questionnaire in quartiles of supplement intake and no supplement. Vitamin C wasmeasured in plasma as ascorbic acid.Results:Carotid IMT progressed 10.0±16.5 μm/year (mean±SD) among all those with follow-up (n=500; 87%). For those who took vitamin C supplements, carotid IMT progression increased with dose (p-trend=0.0009). Among persons in the highest quartile (857-5000 mg/day) of vitamin C supplement intake compared to those not consuming any vitamin C supplements, carotid IMT progression increased three-fold (20.3±2.6 versus 7.6±1.8 μm/year (mean±SD); p<0.001). The adverse association of vitamin C supplement intake with carotid IMT was two-fold greater in the upper tertile of serum cholesterol compared to the lower two tertiles (p=0.01). In contrast to the adverse association of vitamin C supplements, vitamin C intake from food had a weak protective relationship on carotid IMT progression (reduced progression -5.0±1.9 μm/year; p=0.008).Conclusions:Vitamin C supplementation is associated with accelerated early atherosclerosis measured by carotid IMT compared to a protective association with vitamin C from food. Theadverse association of vitamin C supplementation may be greater in patients with higher serum cholesterol levels. The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies. Given these observations,vitamin C supplementation does not appear to be currently advisable for prevention or treatment of atherosclerosis.
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Latham, Michael C., Deborah M. Ash, Diklar Makola, Simon R. Tatala, Godwin D. Ndossi, and Haile Mehansho. "Efficacy Trials of a Micronutrient Dietary Supplement in Schoolchildren and Pregnant Women in Tanzania." Food and Nutrition Bulletin 24, no. 4_suppl_1 (January 2003): S120—S128. http://dx.doi.org/10.1177/15648265030244s109.

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Traditionally, the main strategies used to control micronutrient deficiencies have been food diversification, consumption of medicinal supplements, and food fortification. In Tanzania, we conducted efficacy trials using a dietary supplement as a fourth approach. These were randomized, double-blind, placebo-controlled efficacy trials conducted separately first in children and later in pregnant women. The dietary supplement was a powder used to prepare an orange-flavored beverage. In the school trial, children consumed 25 g per school day attended. In the pregnancy trial, women consumed the contents of two 25-g sachets per day with meals. This dietary supplement, unlike most medicinal supplements, provided 11 micronutrients, including iron and vitamin A, in physiologic amounts. In both trials we compared changes in subjects consuming either the fortified or the nonfortified supplement. Measures of iron and vitamin A status were similar in the groups at the baseline examination, but significantly different at follow-up, always in favor of the fortified groups. Children receiving the fortified supplement had significantly improved anthropometric measures when compared with controls. At four weeks postpartum, the breast milk of a supplemented group of women had significantly higher mean retinol content than did the milk of mothers consuming the nonfortified supplement. The advantages of using a fortified dietary supplement, compared with other approaches, include its ability to control several micronutrient deficiencies simultaneously; the use of physiologic amounts of nutrients, rather than megadoses that require medical supervision; and the likelihood of better compliance than with the use of pills because subjects liked the beverage used in these trials.
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Roy, A., S. E. Evers, and M. K. Campbell. "Dietary supplement use and iron, zinc and folate intake in pregnant women in London, Ontario." Chronic Diseases and Injuries in Canada 32, no. 2 (March 2012): 76–83. http://dx.doi.org/10.24095/hpcdp.32.2.03.

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Introduction We examined the dietary intake of iron, zinc and folate, estimated from both food and supplement sources, in 2019 pregnant women who participated in the Prenatal Health Project (PHP). The PHP recruited pregnant women from ultrasound clinics in London, Ontario, in the years 2002–2005. Methods Participants completed a telephone survey, which included a food frequency questionnaire and questions on dietary supplement use. Frequencies of use of dietary supplements were generated. Nutrient intake values were estimated from food and supplement sources, and summed to calculate total daily intake values. Results Most women took a multivitamin supplement, and many women took folic acid and iron supplements; however, one-fifth of the sample did not take any supplements providing any of the three micronutrients. Despite being of a higher socio-economic status overall, significant proportions of the cohort ranked below the recommended dietary allowance values for iron, zinc, and folate. This suggests there may be other barriers that impact dietary practices. Conclusion Further research is required on how to better promote supplement use and a healthy diet during pregnancy.
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Dove, H., W. M. Kelman, J. A. Kirkegaard, and S. J. Sprague. "Impact of magnesium - sodium supplementation on liveweight gains of young sheep grazing dual-purpose cereal or canola crops." Animal Production Science 52, no. 11 (2012): 1027. http://dx.doi.org/10.1071/an12044.

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Previous experiments have shown that liveweight gains of livestock grazing dual-purpose wheats were increased by 15–60%, by supplementing animals with a 1 : 1 mixture of Causmag (MgO) : salt (NaCl). The supplement appears to overcome both an Na deficiency in wheat forage, plus a reduced rumen Mg absorption due to a high forage (and thus rumen) K : Na ratio. In crop–livestock systems, there is also renewed interest in grazing forage oats and, more recently, barley and dual-purpose canola. The possible need for Mg–Na supplements for sheep grazing these last three crops was investigated in two experiments near Canberra, ACT. In Experiment 1, sheep grazing wheat, oats, barley and canola were either unsupplemented or received a Mg–Na supplement. There was no significant response to the supplement in sheep grazing oats. After adjustment by covariance for differences in sheep numbers per plot, the difference in weight gain/ha of supplemented and unsupplemented sheep grazing barley approached significance (P = 0.068). For the first time in our experience, in this experiment there was also no significant response in sheep grazing wheat. There was a significant interaction between crop type and supplement, because of a 20% depression in liveweight gain in supplemented sheep grazing canola. This negative effect of supplementation on canola was further investigated in Experiment 2, in which sheep grazing only canola were either supplemented or not supplemented. Supplementation in this case had no significant effect on liveweight gain. Our results suggest that there is no need to provide mineral supplements for sheep grazing dual-purpose oats; they also suggest supplementation may be contraindicated for sheep grazing canola. Further work is needed to confirm this and to clarify supplement responses in sheep grazing barley.
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Timbo, Babgaleh B., Stuart J. Chirtel, John Ihrie, Taiye Oladipo, Loy Velez-Suarez, Vickery Brewer, and Robert Mozersky. "Dietary Supplement Adverse Event Report Data From the FDA Center for Food Safety and Applied Nutrition Adverse Event Reporting System (CAERS), 2004-2013." Annals of Pharmacotherapy 52, no. 5 (November 24, 2017): 431–38. http://dx.doi.org/10.1177/1060028017744316.

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Background: The Food and Drug Administration (FDA)’s Center for Food Safety and Applied Nutrition (CFSAN) oversees the safety of the nation’s foods, dietary supplements, and cosmetic products. Objective: To present a descriptive analysis of the 2004-2013 dietary supplement adverse event report (AER) data from CAERS and evaluate the 2006 Dietary Supplements and Nonprescription Drug Consumer Protection Act as pertaining to dietary supplements adverse events reporting. Methods: We queried CAERS for data from the 2004-2013 AERs specifying at least 1 suspected dietary supplement product. We extracted the product name(s), the symptom(s) reported, age, sex, and serious adverse event outcomes. We examined time trends for mandatory and voluntary reporting and performed analysis using SAS v9.4 and R v3.3.0 software. Results: Of the total AERs (n = 15 430) received from January 1, 2004, through December 31, 2013, indicating at least 1 suspected dietary supplement product, 66.9% were mandatory, 32.2% were voluntary, and 0.9% were both mandatory and voluntary. Reported serious outcomes included death, life-threatening conditions, hospitalizations, congenital anomalies/birth defects and events requiring interventions to prevent permanent impairments (5.1%). The dietary supplement adverse event reporting rate in the United States was estimated at ~2% based on CAERS data. Conclusions: This study characterizes CAERS dietary supplement adverse event data for the 2004-2013 period and estimates a reporting rate of 2% for dietary supplement adverse events based on CAERS data. The findings show that the 2006 Dietary Supplements and Nonprescription Drug Consumer Protection Act had a substantial impact on the reporting of adverse events.
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Yen, Peggy K. "Food and Supplement Safety." Geriatric Nursing 26, no. 5 (September 2005): 279–80. http://dx.doi.org/10.1016/j.gerinurse.2005.08.001.

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Sousa, Alessandra Gaspar, and Teresa Helena Macedo da Costa. "Diet and supplement assessment in a Brazilian urban population." Revista de Saúde Pública 55 (May 24, 2021): 26. http://dx.doi.org/10.11606/s1518-8787.2021055002356.

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OBJECTIVE: To assess total usual nutrient intakes from foods and dietary supplements by age, sex, physical activity, and nutritional status, and to compare usual nutrient intakes to the Dietary Reference Intakes among non-users and users of dietary supplements in an urban population. METHODS: Cross-sectional population-based survey with 506 adults conducted in the city of Brasília, Brazil, using 24h food recalls. The 24-HR was collected on two nonconsecutive days, for which individuals reported all food, supplements, and beverages consumed in the previous 24 hours. The estimates of mean and the distribution percentiles were adjusted to reflect usual nutrient intake using the Iowa State University method. The prevalence of inadequate micronutrient intake was estimated according to sex using the Estimated Average Requirement (EAR), and values above the Tolerable Upper Intake Level (UL) were also considered. Also, a comparison was made of the total mean usual intake between supplement users and non-users according to BMI and physical activity. RESULTS: The total mean usual dietary intake was significantly higher among users than non-users of dietary supplements (p ≤ 0.02). Dietary supplement use increased intakes of nutrients and decreased prevalence of inadequacy according to sex, with only small (typically < 13%) increases in the population exceeding the Tolerable Upper Intake Level. There was a significant interaction between physical activity and BMI categories with supplement use. CONCLUSIONS: The population that consumes food supplements comprises individuals with more advanced age, female, normal BMI, and physically active. Our findings show that the use of supplements appears beneficial to attain nutrient adequacy. Careful monitoring of intake from food and supplements is recommended, and the statistical methods must be powerful enough to achieve relevant information.
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Vatanparast, Hassan, Rashmi Prakash Patil, Naorin Islam, Mojtaba Shafiee, and Susan J. Whiting. "Vitamin D Intake from Supplemental Sources but Not from Food Sources Has Increased in the Canadian Population Over Time." Journal of Nutrition 150, no. 3 (December 11, 2019): 526–35. http://dx.doi.org/10.1093/jn/nxz291.

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ABSTRACT Background Evidence is lacking to determine whether there have been any changes in dietary or total usual intakes of vitamin D among Canadians, in the light of recent evidence of beneficial health effects beyond bone. Objective We aimed to examine trends in dietary and total usual intake of vitamin D among Canadians aged ≥1 y. Methods This study used nationally representative nutrition data from the Canadian Community Health Survey Cycle 2.2 (CCHS 2004) and CCHS Nutrition in 2015. Dietary intake data were collected with use of two 24-h dietary recalls and dietary supplement use was determined by questionnaire. The National Cancer Institute method was used to estimate the usual intake of vitamin D as well as the prevalence of vitamin D inadequacy among Canadians aged ≥1 y. Results From 2004 to 2015, the usual intake of vitamin D from food significantly decreased (P &lt; 0.05) by 1 μg/d only in vitamin D supplement nonusers. The contribution of Milk and Alternatives food group (i.e., fluid milk, fortified soy beverages, powdered milk, and other milk alternatives) to dietary vitamin D intake significantly decreased (P &lt; 0.05) in both supplement users (by 7.1%) and nonusers (by 5.8%). Prevalence of vitamin D supplement use and percentage contribution of vitamin D from supplemental sources significantly increased (P &lt; 0.05) by 5.0% and 14.9%, respectively, from 2004 to 2015. Total usual intake of vitamin D (food + supplement) significantly increased (P &lt; 0.05) from 15.1 ± 0.3 μg/d in 2004 to 31.5 ± 1.8 μg/d in 2015 in vitamin D supplement users. In contrast to vitamin D supplement nonusers, the prevalence of vitamin D inadequacy significantly decreased (P &lt; 0.05) from 20.6% to 14.1% among users of vitamin D supplements. Conclusions The prevalence of vitamin D supplement use and the percentage contribution of vitamin D from supplemental sources has increased in the Canadian population over an 11-y period.
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Malone, Katie, and Jaymelynn K. Farney. "PSI-7 Evaluation of Form of Supplement with or Without Ionophore on Stocker Steer Performance While on Bromegrass." Journal of Animal Science 99, Supplement_1 (May 1, 2021): 224. http://dx.doi.org/10.1093/jas/skab054.367.

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Abstract Cattle producers have a wide variety of supplements available to increase gains, extend forage, and balance for forage deficiencies; however, this becomes challenging with determining the correct supplement for a specific operation. Therefore, the objective of this study was to evaluate form of supplementation with or without the addition of ionophore on cattle gains while grazing bromegrass during the summer. Growing steers (n = 72; initial weight 245 ± 22 kg) were used in a 2 x 2 + 2 factorial treatment and grazed 18 bromegrass pastures from March through August. Factors include base form of supplement at two levels [pressed block (Mintrate) or hand-fed 50:50 corn:DDG blend offered 3x weekly at 0.25% BW] and ionophore at two levels (Rumensin; none or 90 g/ton). Other treatments were liquid supplement (Mix30) and control (free-choice mineral). Cattle were weighed at beginning and end of 150 d grazing period and every 28 d, with carcass ultrasound on d 150. Data was analyzed with ProcMixed (SAS v. 9.4, Cary, NC) with pre-planned contrasts. Hand-fed supplemented steers had greater ADG than steers on free-choice supplements (P = 0.05). Between d 56 and d 140 on grass, hand-fed steers had greater ADG than steers on the block treatment with liquid supplemented steers being intermediate (P &lt; 0.10). Addition of ionophore did not result in differences in ADG (P = 0.43). There was not difference in ADG between steers that were supplemented or only received free-choice mineral (P = 0.48). Marbling score tended (P = 0.08) to be greater for control steers than all other supplemented. Backfat tended (P = 0.08) to be greater with hand-supplemented steers than steers on a free-choice supplement. Even though supplemented steers did not outperform non-supplemented steers during this project, there was gain advantages to hand-feeding supplement instead of a free-choice feed.
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Bakuradze, Tamara, Peter Meiser, Jens Galan, and Elke Richling. "DNA Protection by an Aronia Juice-Based Food Supplement." Antioxidants 10, no. 6 (May 27, 2021): 857. http://dx.doi.org/10.3390/antiox10060857.

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Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H2O2-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules, n = 45) or no supplement (n = 46) daily for eight weeks. Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline (p < 0.05), but the overall effect was low, and neither group showed a decrease in total DNA strand breaks. Conversely, supplement consumption clearly reduced H2O2-induced DNA strand breaks ex vivo (p < 0.001), with statistically significant reductions after four and eight weeks, compared to the control group (p < 0.05). Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation.
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Kobayashi, Etsuko, Yoko Sato, Chiharu Nishijima, and Tsuyoshi Chiba. "Concomitant Use of Dietary Supplements and Medicines Among Preschool and School-Aged Children in Japan." Nutrients 11, no. 12 (December 4, 2019): 2960. http://dx.doi.org/10.3390/nu11122960.

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Dietary supplement use is widespread amongst the general population including in children and adolescents. The ingredients in dietary supplements can interact with medicines when patients take them concomitantly. However, the prevalence of the concomitant use of dietary supplements and medicines in Japan among children remains unclear. To clarify this issue, a nationwide internet survey was administered to 55,038 mothers (25 to 60 years old) of preschool- or school-aged children in Japan. Among them, 7.6% currently provide dietary supplements and 3.2% concomitantly provide dietary supplements and prescription or over-the-counter medicines to their children. The prevalence of concomitant use increased with the children’s grade. Among 1057 mothers with 1154 children who were concomitantly using dietary supplements and medicines, 69.1% provided dietary supplements without physician consultation because they considered dietary supplements as only foods and therefore safe. Although the purpose of the use and types of dietary supplement differed between boys and girls, the most popular product was probiotics in both boys and girls. Among concomitant users, 8.3% of mothers gave dietary supplements for treatment of diseases and 4.9% mothers recognized the adverse events of dietary supplements in their child. The findings of this study suggest that mothers’ knowledge about the risk of using dietary supplement with medicines is insufficient. Parental education about the safety of dietary supplements and potential risk of drug–supplement interaction is needed.
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Gong, Weiyan, Ailing Liu, Yecheng Yao, Yanning Ma, Caicui Ding, Chao Song, Fan Yuan, et al. "Nutrient Supplement Use among the Chinese Population: A Cross-Sectional Study of the 2010–2012 China Nutrition and Health Surveillance." Nutrients 10, no. 11 (November 12, 2018): 1733. http://dx.doi.org/10.3390/nu10111733.

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Nutrient supplements play a key role in managing malnutrition/chronic diseases and are commonly used in the world, but few studies described the prevalence of nutrient supplement use at the national level in China. To our knowledge, this study provides the first detailed investigation of nutrient supplement use in a nationally representative sample of the Chinese population. This study aimed to describe the prevalence of the nutrient supplement use among the Chinese population aged 6 years or older in 2010–2012. A stratified multistage cluster sampling method was conducted to recruit participants from 150 surveillance sites. The demographic characteristics and information about nutrient supplement use were collected through an interview-administrative questionnaire. A total of 74,501 children and adults (excluding the pregnant women) were included in the study (mean age, 35.7 years; male, 47.0%, female, 53.5%). Only 0.71% of the participants reported using nutrient supplements in the previous month. Participants aged 6–11 years and 60 years and above, female, living in large urban, with higher education level and higher family incomes were more likely to use nutrient supplements than their counterparts (p < 0.05). The prevalence of nutrient supplement use increased with age in Chinese adults. The highest usage among the nutrient supplements was multi-vitamins and minerals with 0.37%. More females used single vitamin, multi-mineral, multi-vitamins and minerals than males (p < 0.05). The nutrient supplement use proportion was highest amongst the participants with a health problem, and the participants who had no idea about their health conditions were the least likely to use the nutrient supplements (p < 0.05). The prevalence of nutrient supplement use was low among the Chinese population in 2010–2012. Further research is required to understand the social cognition, usage reasons, dosage and consumption motivation of NS, and the relationships with health effects, to ensure that the nutrient supplements can be appropriately promoted in China.
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Giammarioli, Stefania, Concetta Boniglia, Brunella Carratù, Marco Ciarrocchi, Flavia Chiarotti, Maurizio Mosca, and Elisabetta Sanzini. "Use of food supplements and determinants of usage in a sample Italian adult population." Public Health Nutrition 16, no. 10 (October 1, 2012): 1768–81. http://dx.doi.org/10.1017/s1368980012004314.

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AbstractObjectiveThe aims were to collect data on consumption of different food supplements in a sample of the adult Italian population and to characterize users by demographic, physical and health-related characteristics, lifestyle and behaviour.DesignCross-sectional survey.SettingThe study was conducted in 2008 in ten towns of Italy (two towns from each of the five macro-areas: Northwest, Northeast, Centre, South and Islands).SubjectsAdults (n10 000) aged ≥18 years were randomly selected and asked to fill in a self-administered questionnaire regarding their use of food supplements and the above variables. The effect of these variables on food supplement use was evaluated by univariate and multivariate logistic regression.ResultsOf the 1723 individuals who returned the questionnaire, 49 % were users of food supplements. A large proportion (54 %) of users used more than one category of food supplement: vitamin and/or mineral supplements were the most used (61 %), followed by supplements with botanicals and botanical extracts (28 %). The results obtained by logistic regression showed that gender, town size, education level, sports practice, regular use of wholemeal cereal-based foods and presence of a low stress level were determinants for the use of food supplements in the examined population. However, these determinants were not shared by all categories of supplements.ConclusionsThe results of this preliminary study highlight that associations between demographic, dietary and lifestyle factors and use of different categories of food supplements differ according to products, and cannot be accounted for simply by dichotomizing individuals as users or non-users.
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Hahn, Martin. "Functional Foods: What are They? How are They Regulated? What Claims Can Be Made?" American Journal of Law & Medicine 31, no. 2-3 (June 2005): 305–40. http://dx.doi.org/10.1177/009885880503100207.

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Scientific studies continue to establish a strong relationship between constituents in foods and dietary supplements and certain diseases. The general population is inundated on a seemingly daily basis by media reports of new studies showing that a food or dietary supplement is useful in treating particular diseases or reducing the likelihood that a consumer will develop particular diseases. With increasing frequency, consumers are looking for foods and supplements to help manage and prevent the onset of disease.Not surprisingly, the food and dietary supplement industries are responding by developing new products and repositioning old products efforts to help consumers manage their health. For example, yogurt used to be positioned only as a delicious component of a meal but now is also promoted for use in weight loss programs after a study showed that the calcium in dairy products is effective in weight loss.
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Chiba, Tsuyoshi, and Nanae Tanemura. "Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users." Nutrients 14, no. 19 (October 3, 2022): 4114. http://dx.doi.org/10.3390/nu14194114.

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Some patients use dietary supplements and medicines concomitantly, with an inappropriate perception of their safety and efficacy. To clarify the perception between dietary supplement and medicine users and non-users, we conducted an internet survey. In this survey, 38.9% of participants used dietary supplements, 32.6% used prescription medicines, and 14.7% used dietary supplements and prescription medicines concomitantly. Then, we conducted a further survey on four groups, dietary supplement and prescription medicine users, dietary supplement only users, prescription medicine only users, and non-users (500 each). Dietary supplement users had favorable outcomes in terms of both the safety and efficacy of dietary supplements compared to dietary supplement non-users. This perception of dietary supplements was independent from medicine use. The awareness of the Health Food Network consumer navigation site, which provides information about dietary supplements for consumers, was the highest among dietary supplement and prescription medicine users, but it was still low (2.2%). In conclusion, consumers who use dietary supplement and prescription medicine concomitantly have favorable outcomes for their safety and efficacy and a low awareness of their interaction. There is a need to provide information, especially regarding the risk of interaction, that takes into account the consumer’s situation.
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de Vries, Hein, Em�lia M. Pajor, Kenny C. J. Curfs, Sander M. Eggers, and Anke Oenema. "How to foster informed decision making about food supplements: results from an international Delphi study." Health Education Research 34, no. 4 (June 1, 2019): 435–46. http://dx.doi.org/10.1093/her/cyz017.

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Abstract Food supplement use can have beneficial and detrimental effects, making informed decisions about supplement use important. How these decisions are made and which communication strategies can stimulate informed decision making is unclear. This study identified the important characteristics of (i) informed decision making about food supplement use and (ii) important factors indicating how to communicate about food supplements to foster informed decision making. An online three-round Delphi study was conducted. International experts within the field of (risk) communication about food supplements or related fields were recruited via email. The participants' age ranged from 25 to 69 years, and sample sizes for the three rounds were 38, 89 and 51, respectively. Experts indicated that for making an informed decision about food supplement use one needs to have knowledge of their positive and negative effects, the ability to compare these effects, knowing alternatives besides supplements, feeling informed, and feeling able (self-efficacious) to make the decision and making the decision voluntarily. Important communication strategies mentioned were: provision of information about positive and negative effects and the nature of these effects including scientific evidence, ensuring information is easily accessible, well ordered, tailored and provided by a trustworthy, credible and independent source.
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Adegboye, Amanda Rodrigues Amorim, Omorogieva Ojo, and Gulshanara Begum. "The Use of Dietary Supplements Among African and Caribbean Women Living in the UK: A Cross-Sectional Study." Nutrients 12, no. 3 (March 22, 2020): 847. http://dx.doi.org/10.3390/nu12030847.

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Previous studies have shown that the use of dietary supplements is associated with the prevention of birth defects, negative pregnancy outcomes and cardiovascular diseases. However, there might be some ethnic disparities in supplement usage suggesting that women who could benefit from it are not frequent users. This study aimed to characterise the use of dietary supplement among Black African and Black Caribbean women living in the United Kingdom (UK). Furthermore, it evaluated possible associations between the use of dietary supplements and health and diet awareness. A total of 262 women self-ascribed as Black African and Black Caribbean living in the UK completed a comprehensive questionnaire on socio-demographic factors, diet, use of supplements and cultural factors. The main outcome variable was the regular use of any type of dietary supplement. Use of vitamin D and/or calcium was also explored. A stepwise logistic regression analysis was applied to identify predictors of regular use of dietary supplements. A total of 33.2% of women reported regular use of any dietary supplements and 16.8% reported use of vitamin D and/or calcium. There were no significant ethnic differences in the use of dietary supplements. Reporting use of the back of food packaging label (odds ratio (OR) 2.21; 95% CI 1.07–4.55); a self-rated healthy diet (OR 2.86; 95% CI 1.19–6.91) and having cardiovascular disease (CVD), hypertension and/or high cholesterol (OR 3.81; 95% CI 1.53–9.49) increased the likelihood of using any dietary supplement. However, having poorer awareness decreased the likelihood (OR 0.94; 95% CI 0.88–0.99) of using any dietary supplement. For the use of vitamin D and/or calcium supplements, the main predictor was having CVD, hypertension and/or high cholesterol (OR 4.43; 95% CI 1.90–10.35). The prevalence of dietary supplement use was low among African and Caribbean women. Thus, awareness of potential benefits of some dietary supplements (e.g., vitamin D) among the Black population should be promoted.
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Touvier, Boutron-Ruault, Volatier, and Martin. "Efficacy and Safety of Regular Vitamin and Mineral Supplement Use in France: Results from the ECCA Study." International Journal for Vitamin and Nutrition Research 75, no. 3 (May 1, 2005): 201–9. http://dx.doi.org/10.1024/0300-9831.75.3.201.

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This study investigated the prevalence of inadequate micronutrient intake and the proportion of subjects who exceed Tolerable Upper Intake Levels a) with food only, and b) with food+supplements, in a population of French regular supplement users (n = 259). Assessment tools were seven-day records for supplements, three-day records for food intake, and a questionnaire about supplement use. Most subjects were recruited in retail outlets that sold supplements. They were recent users of vitamin/mineral supplements, aged over 15 years, and normo-energy reporters. The prevalence (%) of inadequate intake decreased with the inclusion of mean annual supplements, from 68.0 to 54.8 for magnesium, 55.9 to 40.7 for vitamin C, 53.4 to 43.9 for folic acid, 37.5 to 27.5 for iron, and 40.1 to 29.7 for pantothenic acid. Few subjects exceeded upper intake levels when mean annual intake of supplements was considered. When supplement consumption was considered during the studied week only, the proportion of subjects who were in excess of the upper intake levels was higher (maximum: 9.6% for magnesium). Supplement use brought a nutritional benefit for some targeted nutrients. It was not associated with excessive intake in this study, but could become hazardous if the annual frequency of use were to increase.
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Nishijima, Chiharu, Etsuko Kobayashi, Yoko Sato, and Tsuyoshi Chiba. "Are There Adverse Events after the Use of Sexual Enhancement Nutrition Supplements? A Nationwide Online Survey from Japan." Nutrients 11, no. 11 (November 18, 2019): 2814. http://dx.doi.org/10.3390/nu11112814.

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Dozens of safety alerts for sexual enhancement and weight loss dietary supplements have been launched from the government not only in Japan but also overseas. However, adverse events have been reported only for the use of weight loss supplements, and the prevalence of use and adverse events in sexual enhancement supplements is not known in Japan. To address this issue, we assessed the situation of sexual enhancement supplement use through a nationwide online survey. The prevalence of sexual enhancement supplement use among males was 23.0%. Use of these supplements was higher among younger people than among older people (p < 0.001). In total, 17.6% of users had experienced adverse events, but 58.3% of them did not consult about the events with anybody because of the temporality of their symptoms and their sense of shame. In addition, eight supplement products were found to be possible adulterated supplements in this survey. It is necessary to inform the public about the risk of sexual enhancement supplement use and also prepare a place for consultation on media channels that younger people are more familiar with, in order to monitor adverse events while also preserving their privacy.
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Mason, Marlys J. "Drugs or Dietary Supplements: FDA's Enforcement of DSHEA." Journal of Public Policy & Marketing 17, no. 2 (September 1998): 296–302. http://dx.doi.org/10.1177/074391569801700212.

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The Dietary Supplement Health and Education Act broadened the definition of a dietary supplement and loosened the restrictions for health claims on supplement labeling. The Act has left an unclear boundary between supplements and drugs. In this article, the author examines the legal debate surrounding the definition and regulation of drugs and supplements. The author also discusses recent Food and Drug Administration enforcement activities and court challenges.
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Retiaty, Fifi, Ade Nugraheni, and Astuti Lamid. "SEAWEED AS MICRONUTRIENTS INGREDIENT FOR FOOD SUPPLEMENT." KnE Life Sciences 2, no. 1 (February 1, 2015): 19. http://dx.doi.org/10.18502/kls.v1i0.79.

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In some part of Indonesia seaweed has been used as vegetables dish. The most important component of seaweed isiodine and iron. Gracillariasp is one species of seaweed that can be used as a source of the mikronutrients such as iron, iodine and calcium. Iron Deficiency Anemia and Iodine Deficiency Disorder can cause several diseases also known low haemoglobin level and iodine level in the blood. This preparation of Gracillariasp could supplement micro-nutrients in the diet. This study was to develop appropriate local technology of Gracillariaspcontainedas an ingredient in the making of food supplement for imorovement of micronutrients intake.The experimental study uses optimum formulated comosition from seaweed.Based on the practical in the area (Bali), the formula of seaweed compose of seaweed of Gracillaria with additional of 20 % salty fish extract, 5 % dextrin. The seaweeds contains high of carbohydrate, iodine, calcium and iron but low in protein and lipid. Appropriate technology of dried seaweed supplement could be prepared at home. Theseseaweed supplements could be advocated in rural arealevel or posyandufor combating under nutrition status of the children.The formula of direct seaweed inclusion inthe supplement is preferred due to green colour and acceptable taste compared to dried seaweed. The serving sice of 25 g of this product could be cover children’s need about 23 % in iodine, 100 % in iron and 22- 35 % in calcium. Keywords: seaweed, Gracillariasp, iodine, iron, food supplement
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39

Morris, P. C., and S. J. Davies. "Thiamin supplementation of diets containing varied lipid: carbohydrate ratio given to gilthead seabream (Sparus aurata L.)." Animal Science 61, no. 3 (December 1995): 597–603. http://dx.doi.org/10.1017/s1357729800014193.

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AbstractOn the basis of their respective metabolizable energy contents, supplemental marine oil was partially replaced with a maize starch/dextrin mixture in diets containing approximately 500 g crude protein per kg food thus lowering the total dietary lipid concentration from 141·6 to 100·9 g/kg. The basal diets were then supplemented with thiamin hydrochloride at 0·5, 5·0 and 10·0 mg/kg food to produce six test diets in all. After 182 days of feeding, the fish given the diets containing the higher lipid content with a thiamin supplement of 10·0 mg/kg had shown significantly better growth and food utilization (food conversion efficiency and apparent net protein utilization) than the fish presented with the remaining five diets. Thiamin supplements of 5 mg/kg or less resulted in poorer performance amongst the fish given the high lipid diets. The fish given all three of the low oil diets performed poorly by comparison with those given the high lipid, high thiamin diet and performance was comparable with that of the fish given the high lipid diets containing thiamin at 5 mg/kg or less. Proximate carcass composition in terms of moisture, protein and lipid was unaffected in response to diet. Glycogen accumulation in the liver was significantly elevated amongst the fish given the low lipid diet where the thiamin supplement was 5·0 mg/kg or more. The haematology of the fish was not significantly altered in response to diet although elevated haematocrit was associated with decreasing thiamin supplementation. It would appear that for the seabream, lipid and carbohydrate are not exchangeable on the basis of their metabolizable energy content. When given high lipid diets the thiamin requirement of the seabream is in excess of 5·0 mg/kg and increasing the thiamin supplement to 10 mg/kg in high carbohydrate diets made no impact on performance.
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40

Onel, Suzan. "Dietary Supplements: A Definition That is Black, White, and Gray." American Journal of Law & Medicine 31, no. 2-3 (June 2005): 341–48. http://dx.doi.org/10.1177/009885880503100208.

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The Dietary Supplement Health and Education Act of 1994 (“DSHEA” or “the Act”) was a seminal event in the world of food and drug law. The Act took a controversial category of product traditionally regulated by FDA as either a food or a drug, depending upon the product claims and formulation, and created a new regulatory category called “dietary supplement” that was placed within the “food” definition. As such, products meeting the “dietary supplement” definition benefited in two significant ways, (1) dietary supplements could make “structure/function” claims traditionally within the realm of drug products; and (2) unlike food ingredients, dietary ingredients could be used in dietary supplements without being either approved food additives or generally recognized as safe (“GRAS”) ingredients. These legislative provisions significantly changed the legal, corporate, and consumer landscape, allowing products to enter the marketplace with broadbased claims without FDA premarket review or approval of the ingredients, formulation, or product claims.
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41

Hutt, Peter Barton. "FDA Statutory Authority to Regulate the Safety of Dietary Supplements." American Journal of Law & Medicine 31, no. 2-3 (June 2005): 155–74. http://dx.doi.org/10.1177/009885880503100202.

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For almost a century, the Food and Drug Administration (FDA) has regulated nutrients and other dietary supplement ingredients and products under the food provisions initially of the Federal Food and Drugs Act of 1906 and now of the Federal Food, Drug and Cosmetic Act of 1938 (“FD&C Act”), as amended. Congress amended the FD&C Act through the Food Additives Amendment of 1958 and the Color Additive Amendments of 1960 to strengthen FDA authority over food ingredient safety. In 1976, Congress enacted the Vitamin-Mineral Amendments which provides that FDA may limit the contents of dietary supplements only for safety reasons. In 1994, Congress enacted the Dietary Supplement Health and Education Act (“DSHEA”) to continue the regulation of dietary supplements under the food provisions of the FD&C Act but to replace the food additive provisions with separate safety requirements for dietary supplements and dietary ingredients.
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42

Magalhães, Lidiane Pereira, Júlia de Castro Querido, Mayara Freitas de Oliveira, Nathalia Soares Machado, and Luciana Pellegrini Pisani. "Análise da alteração sensorial em alimentos preparados com suplementos em pó sem sabor." Braspen Journal 35, no. 1 (May 1, 2020): 34–41. http://dx.doi.org/10.37111/braspenj.2020351007.

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Introduction: In oncology patients, the risk of malnutrition is constant due to several factors, such as negative energy balance and losses of musculoskeletal mass. Cancer treatments often results in several side effects that directly affect food intake, representing nutritional risk. As a strategy, industrialized supplements are prescribed, however, due to the nausea and dysgeusia commonly found in these patients, the tendency is to accept versions flavorless. A blind sensory evaluation was performed using culinary preparations increased with flavorless powdered industrial supplements. Methods: Three recipes were produced in an UNIFESP Food Technology Laboratory, a cornmeal cake, a simple omelet and an avocado cream. Each recipe was repeated 4 times, in 3, added supplement of 3 different brands and one without addition. The preparations were arranged in similar containers identified by numbers and assessors were asked to taste the food by giving grades 1 through 5 for appearance, taste, aroma and texture. The assessors served themselves randomly, not knowing which preparations contained the supplement or which brand they belonged to and filled out the sensory evaluation form. Results: Fourteen individuals were submitted to the sensorial test. It was noted that sweet supplemented preparations, such as cornmeal cake and avocado cream, were better accepted, with average approval of 86% and 76.3%, respectively, while omelet obtained 51.6%. It was also found that all individuals were able to notice the presence of supplement in the omelet and avocado cream, and less frequently in cornmeal cake. Conclusion: The brand’s orientation is not to submit supplements to high temperatures, because of the risk of nutritional loss, however, in patient’s reports, the insertion of supplement in preparations is noticeable, the proposal would be an alternative use to enrich the daily preparations.
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43

Chen, Zhen, Xiaofang Lian, Meichen Zhou, Xiuli Zhang, and Cong Wang. "Quantitation of L-cystine in Food Supplements and Additives Using 1H qNMR: Method Development and Application." Foods 12, no. 12 (June 20, 2023): 2421. http://dx.doi.org/10.3390/foods12122421.

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Cystine-enriched food supplements are increasingly popular due to their beneficial health effects. However, the lack of industry standards and market regulations resulted in quality issues with cystine food products, including cases of food adulteration and fraud. This study established a reliable and practical method for determining cystine in food supplements and additives using quantitative NMR (qNMR). With the optimized testing solvent, acquisition time, and relaxation delay, the method exhibited higher sensitivity, precision, and reproducibility than the conventional titrimetric method. Additionally, it was more straightforward and more economical than HPLC and LC-MS. Furthermore, the current qNMR method was applied to investigate different food supplements and additives regarding cystine quantity. As a result, four of eight food supplement samples were found to be inaccurately labeled or even with fake labeling, with the relative actual amount of cystine ranging from 0.3% to 107.2%. In comparison, all three food additive samples exhibited satisfactory quality (the relative actual amount of cystine: 97.0–99.9%). Notably, there was no obvious correlation between the quantifiable properties (price and labeled cystine amount) of the tested food supplement samples and their relative actual amount of cystine. The newly developed qNMR-based approach and the subsequent findings might help standardization and regulation of the cystine supplement market.
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44

Trudeau, Madden, Parnell, Gibbard, and Shearer. "Dietary and Supplement-Based Complementary and Alternative Medicine Use in Pediatric Autism Spectrum Disorder." Nutrients 11, no. 8 (August 1, 2019): 1783. http://dx.doi.org/10.3390/nu11081783.

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Previous literature has shown that complementary and alternative medicine (CAM) is steadily increasing in autism spectrum disorder (ASD). However, little data is currently available regarding its use, safety, and efficacy in children with ASD. Thus, the purpose of this study is to describe the use of supplement-based CAM therapies in children between the ages of 4 to 17 years with ASD. This population-based, cross-sectional study evaluated children with ASD regarding supplement use. A total of 210 participants were recruited from a variety of sources including educational and physical activity programs, and social media to complete a questionnaire. Primary caregivers provided information on current supplement based CAM use. Data evaluated the proportion of children that used supplement therapies, the types of supplements used, reasons for use, perceived safety, and demographic factors associated with use (e.g. income, parental education, severity of disorder). Seventy-five percent of children with ASD consumed supplements with multivitamins (77.8%), vitamin D (44.9%), omega 3 (42.5%), probiotics (36.5%), and magnesium (28.1%) as the most prevalent. Several supplements, such as adrenal cortex extract, where product safety has not yet been demonstrated, were also reported. A gluten free diet was the most common specialty diet followed amongst those with restrictions (14.8%). Health care professionals were the most frequent information source regarding supplements; however, 33% of parents reported not disclosing all their child’s supplements to their physician. In conclusion, the use of supplement therapies in children with ASD is endemic and highlights the need for further research concerning public health education surrounding safety and efficacy.
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45

Hys, Katarzyna. "Healthcare products and food supplements in Poland - a comparison." MATEC Web of Conferences 183 (2018): 01006. http://dx.doi.org/10.1051/matecconf/201818301006.

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The analysis of the level of consumption of food supplements by Poles raises increasing controversy. Many communities pay attention to the alarming situation, including, among others, Central Apothecary Council, National Institute of Medicine, Office of Competition and Consumer Protection, National Sanitary Inspectorate or the Supreme Chamber of Control. For the purpose of this paper, the studies were conducted with the use of the desk research technique. There are many factors which affect the increase in food supplement sales in Poland. One of them is the lack of basic client knowledge concerning the differences between healthcare products and food supplements. Clients identify supplements with medicine, which is wrong. Due to the above, the purpose of the paper is to demonstrate the differences between healthcare products and food supplements. As result, a set of criteria will be established, which will be used to conduct a comparative analysis for a healthcare product and food supplement.
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46

Lentjes, Marleen A. H. "The balance between food and dietary supplements in the general population." Proceedings of the Nutrition Society 78, no. 1 (October 30, 2018): 97–109. http://dx.doi.org/10.1017/s0029665118002525.

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In the past, vitamins and minerals were used to cure deficiency diseases. Supplements nowadays are used with the aim of reducing the risk of chronic diseases of which the origins are complex. Dietary supplement use has increased in the UK over recent decades, contributing to the nutrient intake in the population, but not necessarily the proportion of the population that is sub-optimally nourished; therefore, not reducing the proportion below the estimated average requirement and potentially increasing the number at risk of an intake above the safety limits. The supplement nutrient intake may be objectively monitored using circulation biomarkers. The influence of the researcher in how the supplements are grouped and how the nutrient intakes are quantified may however result in different conclusions regarding their nutrient contribution, the associations with biomarkers, in general, and dose–response associations specifically. The diet might be sufficient in micronutrients, but lacking in a balanced food intake. Since public-health nutrition guidelines are expressed in terms of foods, there is potentially a discrepancy between the nutrient-orientated supplement and the quality of the dietary pattern. To promote health, current public-health messages only advocate supplements in specific circumstances, but not in optimally nourished populations.
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47

Mettler, Samuel, Joëlle Vera Bosshard, Dino Häring, and Gareth Morgan. "High Prevalence of Supplement Intake with a Concomitant Low Information Quality among Swiss Fitness Center Users." Nutrients 12, no. 9 (August 26, 2020): 2595. http://dx.doi.org/10.3390/nu12092595.

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Background: The aim of this study was to screen the prevalence of supplement use in Swiss fitness center users and what information sources they consulted. Methods: Customers of 10 fitness centers were screened with a quantitative questionnaire. Results: Eighty two percent of the 417 fitness center users consumed at least one supplement per week. Supplement intake correlated with training frequency (rs = 0.253, p < 0.001). The most prevalent products were protein supplements (used by 49% of the study population), magnesium (34%), and multi-micronutrient supplements (31%). The average number of supplement servings per week among consumers was 17.1 (SD: 16.1, median: 11.0) and the average number of different products used was 6.9 (SD: 4.4, median: 6.0). The most frequently used information sources were the coach/trainer (28%), the website of the supplement seller (26%), and training peers (24%). Thirty seven percent were informed or informed themselves about potential risks associated with the supplement used. The leading reasons for selecting the information source were the desire for scientific-based information followed by the education level of the informing person. Conclusions: A high prevalence of supplement intake among Swiss fitness center users was associated with a low level of information quality and a low prevalence of risk information. A discrepancy between a desire for high quality evidence-based information and a contrasting behavior was detected.
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48

Milutinović, Milena, Sava Vasić, Ana Obradović, Aida Zuher, Milena Jovanović, Milijana Radovanović, Ljiljana Čomić, and Snežana Marković. "Phytochemical Evaluation, Antimicrobial and Anticancer Properties of New “Oligo Grapes” Supplement." Natural Product Communications 14, no. 6 (June 2019): 1934578X1986037. http://dx.doi.org/10.1177/1934578x19860371.

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This research presents complete data about phytochemical analysis and biological activities of a new dietary supplement for commercial use “Oligo Grapes” (OG), and its individual constituents: lyophilized pomace (LP), clay supplemented with red wine extract, lyophilized pomace ethanolic extract (PE), and red wine extract. OG, as a commercially available food supplement, has not been previously tested for its biological activity. Now we want to present new data about its phytochemical screening, antioxidant and antibacterial activities, and anticancer properties with respect to its cytotoxicity and effects on redox status in colon cancer cell lines. The tested extracts expressed strong antibacterial activity against Proteus mirabilis and Proteus mirabilis ATCC 12453, where the synergy of contents inside the supplement demonstrated a higher influence on the bacteria than its separately tested constituents. Among the investigated extracts, PE, as the extract with the highest phenolics concentration, had remarkable cytotoxic activity on HCT-116 and SW-480 colon cancer cells. Also, the treatments modulated redox status in the investigated cancer cells, by inducing oxidative and nitrosative stress, which could be one of the preferred mechanisms of the anticancer action. Based on the achieved antimicrobial and anticancer properties, there is a need for producing different food supplements and nutritional products originating from grapes. In this respect, the food supplement OG and its health benefits deserve scientific attention and further research.
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49

Nurpeni, Widia Astuti, Abdul Mirad, Aguswan, and Trio Saputra. "Food Suplement Controlling Pada Balai Besar Pengawas Obat Dan Makanan (BPOM) Pekanbaru." Jurnal Karya Ilmiah Multidisiplin (JURKIM) 2, no. 2 (June 30, 2022): 173–78. http://dx.doi.org/10.31849/jurkim.v2i2.10105.

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This service aims to analyze food supplement controlling by the Pekanbaru Food and Drug Supervisory Center with a focus on food supplement supervision. The data analysis method is carried out with a qualitative approach by formulating the existing problems by providing a thorough understanding and analysis by comparing the data that has been obtained in the field. Supervision of food supplement products by Balai Besar POM Pekanbaru is carried out by preparing standards and requirements for product quality and production and distribution by taking into account all aspects of production and quality control, covering the entire series of making food supplements with the aim of ensuring that the products produced always meet quality requirements. which has been determined in accordance with the purpose of its use
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50

Erzurum Alim, N., R. E. Karakaya, and O. P. Turk Fidan. "Dietary supplement use and knowledge among students from a health science faculty in a Turkish University." Food Research 5, no. 5 (September 19, 2021): 116–23. http://dx.doi.org/10.26656/fr.2017.5(5).760.

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Dietary supplements are concentrated sources of nutrients used as an addition to a normal diet with a nutritional or physiological effect. In this cross-sectional study, it was aimed to determine the factors of dietary supplement use, the related knowledge, and their relationship with supplement use in a faculty of health sciences among university students. This cross-sectional study was carried out with 333 voluntary university students from Ankara Yıldırım Beyazıt University, the Faculty of Health Sciences. A questionnaire form consisting of 5 sections was applied to the students by face-to-face interview method. The most remarked purposes of supplement use were to improve health (44.2%) and boost immunity (22.1%). There was no difference between age, gender, department, coexistent disease, tobacco smoking and alcohol consumption in terms of dietary supplement use (p = 0.611, p = 0.720, p = 0.682, p = 0.062, p = 0.491, and p = 0.658, respectively). No significant difference was observed between physical activity status, the duration of physical activity, dieting status, the source of diet program, daily frequency of main meals and snacks, body mass index (BMI) groups, and the reason for meal skipping among students according to dietary supplement use (p = 0.180, p = 0.205, p = 0.686, p = 0.226, p = 0.533, p = 0.449, p = 0.976, and p = 0.758, respectively). There was not any significant difference between physical activity status, the duration of physical activity, dietary supplement use, dieting status, the frequency of main meals and snacks and BMI in terms of total knowledge score of dietary supplements (p = 0.245, p = 0.713, p = 0.278, p = 0.067, p = 0.466, p = 0.647, and p = 0.851, respectively). Scientific attention should be paid to the use of dietary supplements. Arbitrary approaches can lead to unwanted interactions. Therefore, in order for health and government policies to be established related to dietary supplements, it is essential to determine the factors related to their use.
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