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Journal articles on the topic 'Forkhead box protein A1'

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Jain, Rohit K., Rutika J. Mehta, Harikrishna Nakshatri, Muhammad T. Idrees, and Sunil S. Badve. "High-level expression of forkhead-box protein A1 in metastatic prostate cancer." Histopathology 58, no. 5 (2011): 766–72. http://dx.doi.org/10.1111/j.1365-2559.2011.03796.x.

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HE, KELI, HUI ZENG, XIANQUN XU, ANLING LI, QING CAI, and XINGHUA LONG. "Clinicopathological significance of forkhead box protein A1 in breast cancer: A meta-analysis." Experimental and Therapeutic Medicine 11, no. 6 (2016): 2525–30. http://dx.doi.org/10.3892/etm.2016.3229.

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Ma, Wenqi, Jue Jiang, Miao Li, et al. "The clinical significance of forkhead box protein A1 and its role in colorectal cancer." Molecular Medicine Reports 14, no. 3 (2016): 2625–31. http://dx.doi.org/10.3892/mmr.2016.5583.

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Gayyed, MarianaF, MagdyF Ahmed, MedhatM Soliman, and Maram El-Hussieny. "Expression and prognostic significance of caveolin-1 and forkhead box protein A1 in gastric adenocarcinoma." Egyptian Journal of Pathology 40, no. 2 (2020): 162. http://dx.doi.org/10.4103/egjp.egjp_2_21.

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5

Hu, Dong Gui, and Peter I. Mackenzie. "Forkhead Box Protein A1 Regulates UDP-Glucuronosyltransferase 2B15 Gene Transcription in LNCaP Prostate Cancer Cells." Drug Metabolism and Disposition 38, no. 12 (2010): 2105–9. http://dx.doi.org/10.1124/dmd.110.035436.

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6

Song, Lan, Zhaojun Xu, Ling Li, et al. "Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line." Cell Stress and Chaperones 19, no. 1 (2013): 53–60. http://dx.doi.org/10.1007/s12192-013-0433-z.

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Ren, Hongyu, Pei Zhang, Yong Tang, Mengping Wu, and Weikang Zhang. "Forkhead Box Protein A1 is a Prognostic Predictor and Promotes Tumor Growth of Gastric Cancer [Retraction]." OncoTargets and Therapy Volume 15 (July 2022): 829–30. http://dx.doi.org/10.2147/ott.s383786.

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Liu, Jian, Bohua Chen, Bin Yue, and Junde Yang. "MicroRNA-212 suppresses the proliferation and migration of osteosarcoma cells by targeting forkhead box protein A1." Experimental and Therapeutic Medicine 12, no. 6 (2016): 4135–41. http://dx.doi.org/10.3892/etm.2016.3880.

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Wang, Shixiong, Sachin Singh, Madhumohan Katika, Sandra Lopez-Aviles, and Antoni Hurtado. "High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines." International Journal of Molecular Sciences 19, no. 12 (2018): 4123. http://dx.doi.org/10.3390/ijms19124123.

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Forkhead box A1 (FOXA1) belongs to the forkhead class transcription factor family, playing pioneering function for hormone receptors in breast and prostate cancers, and mediating activation of linage specific enhancers. Interplay between FOXA1 and breast cancer specific signaling pathways has been reported previously, indicating a regulation network on FOXA1 in breast cancer cells. Here in this study, we aimed to identify which are the proteins that could potentially control FOXA1 function in breast cancer cell lines expressing different molecular markers. We first established a luciferase rep

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Wang, Li-Li, Yin-Ling Xiu, Xi Chen, et al. "The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression." Tumor Biology 39, no. 5 (2017): 101042831770621. http://dx.doi.org/10.1177/1010428317706210.

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FOXA1 (forkhead box A1), a member of the FOXA transcription factor superfamily, plays an important role in tumor occurrence and development. However, the relationship between FOXA1 and ovarian cancer has not been reported. We examined normal ovarian tissue and ovarian cancer tissue and found increased FOXA1 expression in the cancer tissue. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry assays demonstrated that transfection with small interfering RNA to silence FOXA1 (si-FOXA1) in ovarian cancer cell lines decreased cell proliferation and induced apoptosis and S

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11

Park, Su H., Ka-wing Fong, Jung Kim, et al. "Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer." Science Advances 7, no. 15 (2021): eabe2261. http://dx.doi.org/10.1126/sciadv.abe2261.

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Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer (PCa) growth. However, how FOXA1 levels are regulated remains elusive and its therapeutic targeting proven challenging. Here, we report FOXA1 as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295. This methylation is recognized by WD40 repeat protein BUB3, which subsequently recruits ubiquitin-specific protease 7 (USP7) to remove ubiquitination and enhance FOXA1 protein stability. They functionally converge in regulating cell cycle genes and promoting PCa growth.

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12

Tokunaga, E., Y. Hisamatsu, S. Okada, et al. "Expression of forkhead-box protein A1 (FOXA1) as a significant prognostic and predictive marker for ER-positive breast cancer." Journal of Clinical Oncology 28, no. 15_suppl (2010): 608. http://dx.doi.org/10.1200/jco.2010.28.15_suppl.608.

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13

Ma, Yunyan, LV Xiaoyan, Xiaojiang Jia, et al. "The Role and Mechanism of Human Papillomavirus16 E7 (HPV16 E7) in the Proliferation and Invasion of Cervical Cancer Cells Through Regulating Forkhead Box Protein A1." Journal of Biomaterials and Tissue Engineering 10, no. 8 (2020): 1206–12. http://dx.doi.org/10.1166/jbt.2020.2481.

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High-risk HPV16 is an important factor for cervical cancer. HPV16 E7 can promote the malignant transformation of cervical epithelial cells. Forkhead box protein A1 (FOXA1) is abnormally expressed in several tumors. Our study assessed HPV16 E7's effect on cervical cancer cells. Hela cells were divided into control group; HPV16 E7 group; and siFOXA1+ HPV16 E7 group followed by analysis of HPV16 E7 and FOXA1 expression by Real-time PCR and Western blot, cell proliferation by MTT assay, Caspase 3 activity, Bax and Bcl-2 expression by Real-time PCR as well as cell invasion by Transwell assay. In HP

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14

Aung, Khin Moh Moh, Siu Yee New, Shuzhen Hong, et al. "Studying forkhead box protein A1–DNA interaction and ligand inhibition using gold nanoparticles, electrophoretic mobility shift assay, and fluorescence anisotropy." Analytical Biochemistry 448 (March 2014): 95–104. http://dx.doi.org/10.1016/j.ab.2013.11.017.

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15

Fu, Xiaoyong, Rinath Jeselsohn, Resel Pereira, et al. "FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer." Proceedings of the National Academy of Sciences 113, no. 43 (2016): E6600—E6609. http://dx.doi.org/10.1073/pnas.1612835113.

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Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)–chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most

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Ademuyiwa, Foluso O., Mangesh A. Thorat, Rohit K. Jain, Harikrishna Nakshatri, and Sunil Badve. "Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores." Modern Pathology 23, no. 2 (2009): 270–75. http://dx.doi.org/10.1038/modpathol.2009.172.

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17

Zhang, Gaihua, Yongbing Zhao, Yi Liu, et al. "FOXA1 defines cancer cell specificity." Science Advances 2, no. 3 (2016): e1501473. http://dx.doi.org/10.1126/sciadv.1501473.

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A transcription factor functions differentially and/or identically in multiple cell types. However, the mechanism for cell-specific regulation of a transcription factor remains to be elucidated. We address how a single transcription factor, forkhead box protein A1 (FOXA1), forms cell-specific genomic signatures and differentially regulates gene expression in four human cancer cell lines (HepG2, LNCaP, MCF7, and T47D). FOXA1 is a pioneer transcription factor in organogenesis and cancer progression. Genomewide mapping of FOXA1 by chromatin immunoprecipitation sequencing annotates that target gen

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Pan, Jie, Zongbin Xu, Meifang Xu, Xiaoyan Lin, Bingqiang Lin, and Mengxin Lin. "Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway." Journal of International Medical Research 48, no. 12 (2020): 030006052097145. http://dx.doi.org/10.1177/0300060520971453.

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Background This study aimed to evaluate the role and the underlying mechanisms of Forkhead box A1 (encoded by FOXA1) in colon cancer. Methods We analyzed FOXA1 mRNA and protein expression in colon cancer tissues and cell lines. We also silenced FOXA1 expression in HCT116 and SW480 cells to evaluate the effects on cell proliferation, cell cycle, migration, and invasion by using MTT, colony formation, flow cytometry, and the Transwell assay, respectively. Results FOXA1 immunostaining was higher in colon cancer tissues than adjacent healthy tissues. FOXA1 mRNA and protein expression was significa

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19

Hirata, Kensuke, Yuki Takakura, Misato Shibazaki та ін. "Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation". Journal of Cellular Biochemistry 120, № 2 (2018): 2259–70. http://dx.doi.org/10.1002/jcb.27551.

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Wang, Ying, Yang Zhang, Huimin Wang, et al. "Aberrantly Up-regulated miR-20a in Pre-eclampsic Placenta Compromised the Proliferative and Invasive Behaviors of Trophoblast Cells by Targeting Forkhead Box Protein A1." International Journal of Biological Sciences 10, no. 9 (2014): 973–82. http://dx.doi.org/10.7150/ijbs.9088.

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21

Zhu, Xuchao, Dan Li, Fei Yu, et al. "miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein." Oncotarget 7, no. 11 (2016): 13139–52. http://dx.doi.org/10.18632/oncotarget.7545.

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22

Endo, Yumi, Tatsuya Toyama, Satoru Takahashi та ін. "Association of MiR-1290 and its potential targets with characteristics of estrogen receptor α-positive breast cancer." Journal of Clinical Oncology 31, № 15_suppl (2013): 614. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.614.

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614 Background: Recent analyses have identified heterogeneity in estrogen receptor (ER) α-positive breast cancer. Subtypes called luminal A and luminal B have been identified, and the tumor characteristics, such as response to endocrine therapy and prognosis are different in these subtypes. However, little is known about how the biological characteristics of ER-positive breast cancer are determined. Methods: In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissue were compared between ERhigh Ki67low tumors and ERlow Ki67hightumors by miRNA and mRN

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23

Yamaguchi, Noritaka, Yuji Nakayama, and Naoto Yamaguchi. "Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6." Journal of Biological Chemistry 292, no. 20 (2017): 8136–48. http://dx.doi.org/10.1074/jbc.m116.763276.

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24

Hamdi, Yosr, Martin Leclerc, Martine Dumont, et al. "Functional Analysis of Promoter Variants in Genes Involved in Sex Steroid Action, DNA Repair and Cell Cycle Control." Genes 10, no. 3 (2019): 186. http://dx.doi.org/10.3390/genes10030186.

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Genetic variants affecting the regulation of gene expression are among the main causes of human diversity. The potential importance of regulatory polymorphisms is underscored by results from Genome Wide Association Studies, which have already implicated such polymorphisms in the susceptibility to complex diseases such as breast cancer. In this study, we re-sequenced the promoter regions of 24 genes involved in pathways related to breast cancer including sex steroid action, DNA repair, and cell cycle control in 60 unrelated Caucasian individuals. We constructed haplotypes and assessed the funct

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Takayama, Ken-ichi, Takashi Suzuki, Shuichi Tsutsumi, et al. "Integrative Analysis of FOXP1 Function Reveals a Tumor-Suppressive Effect in Prostate Cancer." Molecular Endocrinology 28, no. 12 (2014): 2012–24. http://dx.doi.org/10.1210/me.2014-1171.

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The transcriptional network of the androgen receptor (AR), a key molecule of prostate cancer, is frequently modulated by interactions with other transcriptional factors such as forkhead box protein A1 (FOXA1). However, global regulatory mechanisms of AR signaling mediated by such factors have not been well investigated. Here we conducted a chromatin immunoprecipitation sequence analysis, which revealed that another FOX family, FOXP1, is specifically regulated by both AR and FOXA1. We also found that FOXP1 acts as a tumor suppressor in prostate cancer through inhibiting cell proliferation and m

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Sutinen, Päivi, Vesa Rahkama, Miia Rytinki, and Jorma J. Palvimo. "Nuclear Mobility and Activity of FOXA1 with Androgen Receptor Are Regulated by SUMOylation." Molecular Endocrinology 28, no. 10 (2014): 1719–28. http://dx.doi.org/10.1210/me.2014-1035.

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Forkhead box (FOX) protein A1 has been dubbed a pioneer transcription factor because it binds target sites in DNA, thereby displacing nucleosomes to loosen chromatin and facilitating steroid receptor DNA binding nearby. FOXA1 is an important regulator of prostate development, collaborating with androgen receptor (AR). Post-translational modifications regulating FOXA1 are thus far poorly understood. SUMOylation, post-translational modification of proteins by small ubiquitin-like modifier (SUMO) proteins, has emerged as an important regulatory mechanism in transcriptional regulation. In this wor

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Chu, Yang, Linan Bao, Yun Teng, et al. "The Fibrotic Effects of LINC00663 in Human Hepatic Stellate LX-2 Cells and in Bile Duct-Ligated Cholestasis Mice Are Mediated through the Splicing Factor 2-Fibronectin." Cells 12, no. 2 (2023): 215. http://dx.doi.org/10.3390/cells12020215.

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Hepatic fibrosis can develop into cirrhosis or even cancer without active therapy at an early stage. Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of a wide variety of important biological processes. However, lncRNA mechanism(s) involved in cholestatic liver fibrosis remain unclear. RNA sequence data of hepatic stellate cells from bile duct ligation (BDL) mice or controls were analyzed by weighted gene co-expression network analysis (WGCNA). Based on WGCNA analysis, a competing endogenous RNA network was constructed. We identified LINC00663 and evaluated its f

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Wang, Zhuo, Bao-Sheng Sun, Zhi-Shen Chen, et al. "FOXA1 Leads to Aberrant Expression of SIX4 Affecting Cervical Cancer Cell Growth and Chemoresistance." Analytical Cellular Pathology 2022 (April 20, 2022): 1–18. http://dx.doi.org/10.1155/2022/9675466.

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Cervical cancer (CC) is among the most prevalent cancers among female populations with high recurrence rates all over the world. Cisplatin (DDP) is the first-line treatment for multiple cancers, including CC. The main problem associated with its clinical application is drug resistance. This study is aimed at investigating the function and downstream regulation mechanism of forkhead-box A1 (FOXA1) in CC, which was verified as an oncogene in several cancers. Using GEO database and bioinformatics analysis, we identified FOXA1 as a possible oncogene in CC. Silencing of FOXA1 inhibited CC cell grow

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He, Zihao, Xiaolu Duan, and Guohua Zeng. "Identification of potential biomarkers and pivotal biological pathways for prostate cancer using bioinformatics analysis methods." PeerJ 7 (October 4, 2019): e7872. http://dx.doi.org/10.7717/peerj.7872.

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Background Prostate cancer (PCa) is a common urinary malignancy, whose molecular mechanism has not been fully elucidated. We aimed to screen for key genes and biological pathways related to PCa using bioinformatics method. Methods Differentially expressed genes (DEGs) were filtered out from the GSE103512 dataset and subjected to the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The protein–protein interactions (PPI) network was constructed, following by the identification of hub genes. The results of former studies were compared with ours. The relative

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Gosalia, Nehal, Daniel Neems, Jenny L. Kerschner, Steven T. Kosak, and Ann Harris. "Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus." Nucleic Acids Research 42, no. 15 (2014): 9612–22. http://dx.doi.org/10.1093/nar/gku648.

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Abstract Higher order chromatin structures across the genome are maintained in part by the architectural proteins CCCTC binding factor (CTCF) and the cohesin complex, which co-localize at many sites across the genome. Here, we examine the role of these proteins in mediating chromatin structure at the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR encompasses nearly 200 kb flanked by CTCF-binding enhancer-blocking insulator elements and is regulated by cell-type-specific intronic enhancers, which loop to the promoter in the active locus. SiRNA-mediated depletion of CTCF o

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Erdős, Edina, and Bálint László Bálint. "NR2F2 Orphan Nuclear Receptor is Involved in Estrogen Receptor Alpha-Mediated Transcriptional Regulation in Luminal A Breast Cancer Cells." International Journal of Molecular Sciences 21, no. 6 (2020): 1910. http://dx.doi.org/10.3390/ijms21061910.

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Nuclear Receptor Subfamily 2 Group F Member 2 (NR2F2) is a member of the steroid/thyroid hormone receptor superfamily with a crucial role in organogenesis, angiogenesis, cardiovascular development and tumorigenesis. However, there is limited knowledge about the cistrome and transcriptome of NR2F2 in breast cancer. In this study, we mapped the regulatory mechanism by NR2F2 using functional genomic methods. To investigate the clinical significance of NR2F2 in breast cancer, The Cancer Genome Atlas (TCGA) data were used. These results show that a high NR2F2 is associated with better survival of a

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Kerschner, Jenny L., and Ann Harris. "Transcriptional networks driving enhancer function in the CFTR gene." Biochemical Journal 446, no. 2 (2012): 203–12. http://dx.doi.org/10.1042/bj20120693.

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A critical cis-regulatory element for the CFTR (cystic fibrosis transmembrane conductance regulator) gene is located in intron 11, 100 kb distal to the promoter, with which it interacts. This sequence contains an intestine-selective enhancer and associates with enhancer signature proteins, such as p300, in addition to tissue-specific TFs (transcription factors). In the present study we identify critical TFs that are recruited to this element and demonstrate their importance in regulating CFTR expression. In vitro DNase I footprinting and EMSAs (electrophoretic mobility-shift assays) identified

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Mangia, Anita, Concetta Saponaro, Alessandro Vagheggini, et al. "Should Tumor Infiltrating Lymphocytes, Androgen Receptor, and FOXA1 Expression Predict the Clinical Outcome in Triple Negative Breast Cancer Patients?" Cancers 11, no. 9 (2019): 1393. http://dx.doi.org/10.3390/cancers11091393.

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Tumor-infiltrating lymphocytes (TILs) are a valuable indicator of the immune microenvironment that plays the central role in new anticancer drugs. TILs have a strong prognostic role in triple negative breast cancer (TNBC). Little is known about the interaction with the androgen receptor (AR) and forkhead box A1 (FOXA1). We analyzed the relationships between TIL levels, AR, and FOXA1 expression and their clinical significance in TNBC patients. Further, we investigated their interaction with other biomarkers like programmed cell death ligand-1 (PD-L1), breast cancer type 1 susceptibility protein

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Tsintzas, Kostas, Luke Norton, Kamal Chokkalingam, et al. "Independent and combined effects of acute physiological hyperglycaemia and hyperinsulinaemia on metabolic gene expression in human skeletal muscle." Clinical Science 124, no. 11 (2013): 675–86. http://dx.doi.org/10.1042/cs20120481.

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Physiological hyperglycaemia and hyperinsulinaemia are strong modulators of gene expression, which underpins some of their well-known effects on insulin action and energy metabolism. The aim of the present study was to examine whether acute in vivo exposure of healthy humans to hyperinsulinaemia and hyperglycaemia have independent or additive effects on expression of key metabolic genes in skeletal muscle. On three randomized occasions, seven young subjects underwent a 4 h (i) hyperinsulinaemic (50 m-units·m−2·min−1) hyperglycaemic (10 mmol/l) clamp (HIHG), (ii) hyperglycaemic (10 mmol/l) euin

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Grabowska, Magdalena M., Stephen M. Kelly, Amy L. Reese, et al. "Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia." Endocrinology 157, no. 3 (2015): 1094–109. http://dx.doi.org/10.1210/en.2015-1312.

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AbstractA functional complex consisting of androgen receptor (AR) and forkhead box A1 (FOXA1) proteins supports prostatic development, differentiation, and disease. In addition, the interaction of FOXA1 with cofactors such as nuclear factor I (NFI) family members modulates AR target gene expression. However, the global role of specific NFI family members has yet to be described in the prostate. In these studies, chromatin immunoprecipitation followed by DNA sequencing in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA

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Liu, Yang, Yu Fang, Lili Bao, Feng Wu, Shilong Wang, and Siyu Hao. "Intercellular Communication Reveals Therapeutic Potential of Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer." Biomolecules 12, no. 10 (2022): 1478. http://dx.doi.org/10.3390/biom12101478.

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(1) Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high intra-tumoral heterogeneity. The epithelial-mesenchymal transition (EMT) is one of the inducers of cancer metastasis and migration. However, the description of the EMT process in TNBC using single-cell RNA sequencing (scRNA-seq) remains unclear. (2) Methods: In this study, we analyzed 8938 cellular gene expression profiles from five TNBC patients. We first scored each malignant cell based on functional pathways to determine its EMT characteristics. Then, a pseudo-time trajectory analysis wa

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He, Chuan, Shan Lu, Xuan-zhong Wang, et al. "FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy." Acta Pharmacologica Sinica 42, no. 8 (2021): 1324–37. http://dx.doi.org/10.1038/s41401-021-00663-y.

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AbstractFOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. BNIP3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a receptor accounting for priming damaged mitochondria for autophagic removal. In this study we investigated the role of FOXO3a in regulating the sensitivity of glioma cells to temozolomide (TMZ) and its relationship with BNIP3-mediated mitophagy. We showed that TMZ dosage-dependently inhibited the viability of human U87, U251, T98G, LN18 and rat C6 glioma cells with IC50 values of 135.75, 128.26, 142.65, 155

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Kubouchi, Koichi, Kyosuke Shimada, Takamichi Yokoe, and Yutaka Tsutsumi. "Avoidance and Period-Shortening of Neoadjuvant Chemotherapy Against Triple-Negative Breast Cancer in Stages I and II: Importance of Ki-67 Labeling Index and the Recognition of Apocrine-Type Lesions." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094324. http://dx.doi.org/10.1177/1533033820943246.

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Background: Triple-negative breast cancer encompasses heterogeneous subtypes. Neoadjuvant chemotherapy is ineffective against some triple-negative breast cancers, while others show a favorable prognosis despite chemoresistance. Methods: A total of 51 cases with stages I and II triple-negative breast cancer were analyzed; 34 triple-negative breast cancers treated with neoadjuvant chemotherapy were divided into “good responders” (n = 22), showing therapeutic effect G2b or G3 in surgical specimens, and “poor responders” with therapeutic effect G0, G1a, G1b, and G2a (n = 12). Neoadjuvant chemother

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Brea, Lourdes T., Xiaohai Wang, and Jindan Yu. "Epithelial Transcription Factor FOXA1 Regulates Prostate Cancer Immune Response." Journal of the Endocrine Society 5, Supplement_1 (2021): A1017. http://dx.doi.org/10.1210/jendso/bvab048.2080.

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Abstract Background : While localized prostate cancer (PCa) can be mitigated by surgery and radiation, metastatic PCa remains a challenge to treat. Androgen deprivation therapies and androgen receptor (AR) pathway inhibitors are mainstay treatments for advanced PCa. Yet, resistance often develops leading to castration-resistant prostate cancer (CRPC). Forkhead Box A1 (FOXA1) is a pioneer transcription factor that plays pivotal roles in regulating AR activity and promoting epithelial differentiation. Studies have shown that FOXA1 is frequently downregulated in CRPC tumors. Congruently, FOXA1 lo

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Luo, Xin, Zhulin Yang, Xiao Liu, et al. "The clinicopathological significance of forkhead box P1 and forkhead box O3a in pancreatic ductal adenocarcinomas." Tumor Biology 39, no. 5 (2017): 101042831769912. http://dx.doi.org/10.1177/1010428317699129.

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Pancreatic ductal adenocarcinoma is a highly malignant tumor with poor prognosis, and the biomarkers for the early diagnosis, targeting therapy, and prognosis are still not clinically available. This study investigated the expression of forkhead box P1 and forkhead box O3a proteins in human pancreatic ductal adenocarcinoma tumor tissues and pancreatic tissues with and without benign lesions using immunohistochemical staining. Results showed that the positive rates of forkhead box P1 and forkhead box O3a protein expression were significantly lower in pancreatic ductal adenocarcinoma tumors comp

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Song, Lan, Bin Zhang, Yansheng Feng, Xinjing Luo, Xing Wei, and Xianzhong Xiao. "A Role for Forkhead Box A1 in Acute Lung Injury." Inflammation 32, no. 5 (2009): 322–32. http://dx.doi.org/10.1007/s10753-009-9139-x.

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42

Tan, Congcong, Hui Lyu, sanbao Ruan, and bolin Liu. "Abstract 2969: Histone deacetylase (HDAC) inhibitors exhibit antitumor activity in triple negative breast cancer via suppression of HER3 triggered signaling." Cancer Research 82, no. 12_Supplement (2022): 2969. http://dx.doi.org/10.1158/1538-7445.am2022-2969.

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Abstract Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high rate of recurrence and refractoriness due to lack of well-defined molecular targets. Human epidermal growth factor receptor 3 (HER3) is differentially expressed in TNBC cells. Numerous studies indicate that elevated expression of HER3, through its dimerization with another receptor, is a major cause of treatment failure in human cancers. To date, there is no FDA-approved HER3-targeted cancer therapy. HDAC inhibitors (HDACis) have been approved for the treatment of refractory or relap

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Gao, N. "Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation." Development 132, no. 15 (2005): 3431–43. http://dx.doi.org/10.1242/dev.01917.

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Habashy, Hany Onsy, Desmond G. Powe, Emad A. Rakha, et al. "Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance." European Journal of Cancer 44, no. 11 (2008): 1541–51. http://dx.doi.org/10.1016/j.ejca.2008.04.020.

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Wang, Jingyun, Yiding Bian, Yun Liao, Ye Xia, and Xiaoping Wan. "Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a." Oncology Reports 36, no. 2 (2016): 795–802. http://dx.doi.org/10.3892/or.2016.4907.

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Nik Tavakoli, Nasim, Brett D. Hambly, David R. Sullivan, and Shisan Bao. "Forkhead box protein 3: Essential immune regulatory role." International Journal of Biochemistry & Cell Biology 40, no. 11 (2008): 2369–73. http://dx.doi.org/10.1016/j.biocel.2007.10.004.

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Deqiang, Hou, Gao Yufeng, Bai Ning, and Dong Yu. "Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis in Tongue Squamous Cell Carcinoma by Modulating miR-21/FOXG1 Pathway." Current Topics in Nutraceutical Research 17, no. 4 (2019): 463–69. http://dx.doi.org/10.37290/ctnr2641-452x.17:463-469.

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Isoliquiritigenin is a flavonoid commonly found in liquorice and has been identified as a potent anti-tumor agent. The aim of this study was to investigate whether isoliquiritigenin regulates the proliferation and apoptosis of tongue squamous cell carcinoma cells by regulating forkhead box G1 expression via miR-21. MTT assay and flow cytometry were used to analyze cell proliferation and apoptosis, respectively. Quantitative real time polymerase chain reaction and western blotting were used to detect mRNA and protein expression levels, respectively. The relationship between miR-21 and forkhead

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Adamczyk-Gruszka, Olga, Agata Horecka-Lewitowicz, Jakub Gruszka, Monika Wawszczak-Kasza, Agnieszka Strzelecka, and Piotr Lewitowicz. "Endometrial Cancer in Aspect of Forkhead Box Protein Contribution." International Journal of Environmental Research and Public Health 19, no. 16 (2022): 10403. http://dx.doi.org/10.3390/ijerph191610403.

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(1) Background: The present study aimed to investigate the influence of forkhead box (FOX) on endometrial cancer (EC) progression. For a better understanding, the driving mechanisms are vital to identifying correlations between genes and their regulators. (2) Methods: The study enrolled one hundred and three white female patients with confirmed EC. For the analysis, we used next-generation sequencing with the Hot Spot Cancer Panel provided by Illumina Inc., San Diego, CA, USA, and an immunohistochemical analysis of FOXA1, FOXP1, and estrogen receptors. (3) Results: FOXA1 silencing led to a wor

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Wang, Chiung-Min, William Harry Yang, Leticia Cardoso, Ninoska Gutierrez, Richard Henry Yang, and Wei-Hsiung Yang. "Forkhead Box Protein P3 (FOXP3) Represses ATF3 Transcriptional Activity." International Journal of Molecular Sciences 22, no. 21 (2021): 11400. http://dx.doi.org/10.3390/ijms222111400.

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Activating transcription factor 3 (ATF3), a transcription factor and acute stress sensor, is rapidly induced by a variety of pathophysiological signals and is essential in the complex processes in cellular stress response. FOXP3, a well-known breast and prostate tumor suppressor from the X chromosome, is a novel transcriptional repressor for several oncogenes. However, it remains unknown whether ATF3 is the target protein of FOXP3. Herein, we demonstrate that ATF3 expression is regulated by FOXP3. Firstly, we observed that overexpression of FOXP3 reduced ATF3 protein level. Moreover, knockdown

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Afaf T, Elnashar, and Youssef Esraa M. "And p53 in epithelial immunohisto- chemical expression of Forkhead Box (FOX) A1 ovarian cancer." Clinical Journal of Obstetrics and Gynecology 5, no. 2 (2022): 061–66. http://dx.doi.org/10.29328/journal.cjog.1001109.

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Background: Ovarian cancer (OC) is the fifth cause of cancer mortality in females. There were an estimated 300,000 new cases of OC diagnosed worldwide in 2018, corresponding to 3.4% of all cancer cases among women. The high mortality rate of OC attributed to asymptomatic growth of the tumor leads to its diagnosis at advanced stages. About 85% - 90% of OC are epithelial including serous, endometrioid, clear cell, and mucinous carcinoma. Aim: To study the immunohistochemical (IHC) expression of FOXA1 and p53 in epithelial OC and its association with prognostic indicators such as age, tumor size,

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