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Dissertations / Theses on the topic 'Forkhead proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Bulmer, Richard. "The regulation of the cell division cycle by forkhead proteins in Schizosaccharomyces pombe." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424014.

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2

Pic-Taylor, Aline. "The regulation of the cell division cycle by forkhead proteins in Saccharomyces cerevisiae." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341787.

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3

Fu, Wei. "Regulation of FOXO stability and activity by MDM2 E3 ligase." [Tampa, Fla] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002222.

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4

Black, Markaisa. "FOX proteins as novel negative regulators of lung fibrosis and mitochondrial respiration." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530270199796482.

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5

Oh, Seung Wook. "Regulation of Life Span by DAF-16/Forkhead Transcription Factor in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/22.

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The insulin/IGF-1 signaling pathway plays a pivotal role in life span regulation in diverse organisms. In Caenorhabditis elegans, a PI 3-kinase signaling cascade downstream of DAF-2, an ortholog of the mammalian insulin and insulin-like growth factor-1 (IGF-1) receptor, negatively regulates DAF-16/forkhead transcription factor. DAF-16 then regulates a wide variety of genes involved in longevity, stress response, metabolism and development. DAF-16 also receives signals from other pathways regulating life span and development. However, the precise mechanism by which DAF-16 directs multiple funct

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6

Jain, Nitya. "Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/416.

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Adaptive immunity requires T cell responses to foreign pathogens to be counterbalanced with the need to limit collateral destruction of the host’s own tissues. Further, the presence of a substantial pool of lymphocytes capable of recognizing selfantigen in the periphery poses a threat to the maintenance of peripheral tolerance and prevention of autoimmunity. Regulatory T cells (Treg) that can suppress potentially self-reactive T cells are critical regulators of peripheral tolerance as well as initiation of immune responses. Treg cells employ several context-dependent mechanisms to establish re

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7

Park, Sungman. "AKT function and human oncogenesis." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001885.

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8

Corpuz, Patrick S. "Forkhead protein, FoxL2, in activin regulation of FSH gene expression." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465092.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 19, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 71-77).

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9

Mahajan, Anjali. "Interactions of Forkhead-Associated Domain, FHA1 of Saccharomyces Cerevisiae Rad53 kinase with itself and the biological partners, Mdt1 and Rad9." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164825397.

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10

Tong, Ho-kwan. "Functional regulation of the forkhead box M1 transcription factor by Raf/MEK/MAPK signaling." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37654597.

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11

Tong, Ho-kwan, and 湯皓鈞. "Functional regulation of the forkhead box M1 transcription factor by Raf/MEK/MAPK signaling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37654597.

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12

Sather, Blythe Duke. "CD4+ Foxp3+ regulatory T cell homing & homeostasis /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8343.

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13

Viscardi, Lucas Henriques. "História evolutiva da subfamília FOXP : análise evolutiva molecular e estrutural em tetrápodes." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/150633.

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A família gênica Forkhead P {FOXP) tem sido alvo de muitos estudos envolvendo evolução do cérebro e comportamento animal. Destacam-se particularmente as investigações com o gene FOXP2, que indicam que mudanças neste gene estariam associadas com a evolução da vocalização em algumas espécies de mamíferos, incluindo o Homo sapiens. Recentemente, estudos de desordem intrínseca de proteínas (IDPs) tem ganhado ênfase no contexto evolut ivo, visto que uma correlação posit iva entre regiões de desordem e altas taxas evolutivas tem sido observada. Através de um conjunto de abordagens que inclui predize

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14

Rohini, Rajan Meenu. "Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)." Doctoral thesis, Linköpings universitet, Avdelningen för cellbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-131421.

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Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. In spite of significant research in field of insulin signaling, very little has been known about the mechanisms that lead to insulin resistance and T2D. We aim for network-wide knowledge of insulin signaling in human adipocytes and to identify me

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15

Chappert, Pascal. "Homéostasie et mécanisme d'action in vivo des lymphocytes T régulateurs CD4+CD25+Foxp3+ chez la souris." Paris 6, 2007. http://www.theses.fr/2007PA066312.

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Homéostasie et mécanisme d’action in vivo des lymphocytes T régulateurs CD4+CD25+Foxp3+ chez la souris Parmi les différentes sous populations de cellules T, les cellules T régulatrices CD4+CD25+ (Tregs), gouvernées par le facteur de transcription Foxp3, représentent un lignage unique de cellules dédiées au maintien de la tolérance immune au soi. Des travaux préalables au sein du laboratoire avaient pu montrer leur potentialité dans le cadre de protocoles d’induction de tolérance à long terme en thérapie génique ou cellulaire vis-à-vis d’un antigène donné chez la souris. Les travaux présentés i

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16

Hung, Chien-Min. "mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/845.

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Recent studies suggest adipose tissue plays a critical role in regulating whole body energy homeostasis in both animals and humans. In particular, activating brown adipose tissue (BAT) activity is now appreciated as a potential therapeutic strategy against obesity and metabolic disease. However, the signaling circuits that coordinate nutrient uptake and BAT function are poorly understood. Here, I investigated the role of the nutrient-sensing mTOR signaling pathway in BAT by conditionally deleting Rictor, which encodes an essential component of mTOR Complex 2 (mTORC2) either in brown adipocyte

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17

Hung, Chien-Min. "mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/845.

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Recent studies suggest adipose tissue plays a critical role in regulating whole body energy homeostasis in both animals and humans. In particular, activating brown adipose tissue (BAT) activity is now appreciated as a potential therapeutic strategy against obesity and metabolic disease. However, the signaling circuits that coordinate nutrient uptake and BAT function are poorly understood. Here, I investigated the role of the nutrient-sensing mTOR signaling pathway in BAT by conditionally deleting Rictor, which encodes an essential component of mTOR Complex 2 (mTORC2) either in brown adipocyte

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18

Ricci, Anamaria Ritti. "FOXO3a em leiomioma e leiomiossarcoma uterinos: avaliação de seu potencial para terapia alvo in vitro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27022019-123144/.

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Os tumores de musculatura liso do útero se desenvolvem a partir do miométrio e podem apresentar carcterísticas clínicas malignas e benignas. Dentre eles, o leiomiossarcoma (LMS) é o tumor maligno mais comum, com altas taxas de metástase e recidiva, mesmo sendo diagnosticado em estágios iniciais. Já os leiomiomas (LM) são os tumores benignos mais frequentes em mulheres em idade reprodutiva. Ambos possuem mesma diferenciação celular, porém com comportamentos clínico e biológico bastante distintos, e até o momento não se dispõe de tratamento específico ou curativo. Nesse contexto, a busca por nov

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19

Rush, Craig M. "Characterization of MAX and FOXA2 mutations unique to endometrial cancer." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542204873523922.

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20

Ma, Qiuping. "Role of FoxO Factors as the Nuclear Mediator for PTEN-AR Antagonism in Prostate Cancer Cells." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002559.

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21

Fappi, Alan. "Efeitos do ácido graxo ômega-3 na prevenção da atrofia muscular induzida pela dexametasona." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-13012014-114428/.

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Várias condições podem estar associadas com a atrofia muscular, tais como inatividade, envelhecimento, septicemia, diabetes, câncer e uso de glicocorticoides. Todas estas condições levam a atrofia muscular através de mecanismos que incluem aumento da degradação proteica e/ou redução na síntese proteica, envolvendo pelo menos cinco sistemas: lisossomal, da calpaína, das caspases, metaloproteinases e o sistema ubiquitina-proteasoma (SUP). Glicocorticoides, tais como a dexametasona, acarretam atrofia muscular atuando em quase todos esses sistemas, com significante ativação do SUP e lisossomal, af

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22

Perumal, Kershia. "The role of Tyr540 in dimerisation of the FOXP forkhead domain." Thesis, 2014.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. Johannesburg, 2013.<br>The forkhead box (FOX) proteins are a family of transcription factors that interact with DNA via a winged helix motif that forms part of the forkhead domain. The FOXP (FOXP1-4) subfamily is unique in the family in that the forkhead domains of these proteins exhibit domain swapping where structural elements are exchanged via extension of the hinge-loop region. The FOXP subfamily members have high sequence

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23

Kohoutová, Klára. "Studium struktury a interakcí vybraných forkhead transkripčních faktorů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436410.

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This diploma thesis is a part of a project aiming to develop and study specific inhibitors of FOXO3 transcriptional activity. FOXO3 belongs together with FOXO1, FOXO4 and FOXO6 to FOXO subfamily of forkhead family transcription factors. FOXO transcription factors are evolutionary conserved proteins playing important roles in numerous cellular processes, such as apoptosis, cell cycle regulation and metabolism. Due to their ability to induce apoptosis and to block the cell cycle they are considered tumor suppresors. However, it has been shown that increased activity of FOXO proteins is connected

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24

Murosky, Thomas P. "Regulation of peroxisome proliferator-activated receptor-mediated transcription by LXXLL motif-containing co-activators and the FOXO subclass of forkhead box proteins." 2007. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-2290/index.html.

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25

Chen, Yi-Hsuan, and 陳翌萱. "The Effect of Forkhead box protein M1 (FoxM1) Overexpression on Mitochondrial Dynamics." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/08113938961800944220.

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碩士<br>國立清華大學<br>生物科技研究所<br>102<br>Mitochondria are highly dynamics organelles that are regulated by fission and fusion processes. Mitochondria are responsible for many important functions in cells, such as ATP synthesis, calcium homeostasis, ROS signaling and apoptosis. More and more studies have revealed that mitochondrial dynamics is closely correlated with cellular events. In addition, mitochondrial fusion and fission imbalance has been linked to cancer formation and metastasis. FoxM1 is a transcription factor which is overexpressed in cancer cell and associates with many characteristic fea

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26

Tseng, Kuo-Chang, and 曾國彰. "Characterization of the role played by forkhead box protein O3A in colon cancer stem cell." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/14523421877189797597.

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碩士<br>國立臺灣大學<br>生化科技學系<br>103<br>Cancer stem cell (CSC) is one of the main reasons leading to the recurrence and the metastasis of several cancers. While having abilities as self-renew, quiescence and stress resistance as a normal stem cell, CSC is believed to share many key factors with a normal stem cell. However, due to the less of comprehensive researches and the difficulty in isolation and investigation of CSC, the factors which are essential to the CSC are not yet clear. In this thesis, I tested whether the transcription factor forkhead box protein O3A (FOXO3A), which is known as a neces

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27

Vácha, Petr. "Studium interakce forkhead transkripčního faktoru FOXO4 s DNA a s proteinem 14-3-3." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-350993.

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CHARLES UNIVERSITY IN PRAGUE THE FACULTY OF NATURAL SCIENCE Department of Physical and Macromolecular Chemistry The summary of the doctoral thesis Study of interactions of forkhead transcription factor FOXO4 with DNA and the 14-3-3 protein RNDr. Petr Vácha Scientific supervisor: Prof. RNDr. Tomáš Obšil, Ph.D. Prague 2015 Abstract This doctoral thesis deals with the interaction of human forkhead transcription factor FOXO4 with DNA and regulating 14-3-3 protein respectively. The main aim of this work was detailed characterization of interaction between DNA binding domain of protein FOXO4 with tw

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28

Lin, Song-sian, and 林松賢. "changes in the protein expression of the forkhead transcription factor FoxO6 during differentiation of 3T3-L1 fat cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/68885458136433115316.

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碩士<br>國立中央大學<br>生命科學系<br>102<br>Forkhead box class O (FoxO) transcription factors contained FoxO1, FoxO3, FoxO4, and FoxO6, and they have been respectively reported to regulate diverse cellular functions, including differentiation, energy metabolism, cell survival, and cell cycle. In this study using the preadipocyte-adipocyte differentiation system of 3T3-L1 cells induced by dexamethasone, insulin and 1-methyl-3-isobutylxanthine, we examined changes in the FoxO6 protein expression during the adipogenic process. We found that FoxO6 increased its protein levels by about 100% during the 14-day p

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29

Ganjam, Goutham Kumar. "Regulation of rat Liver Glucokinase Gene Expression by Sterol Regulatory Element Binding Protein-1a and Forkhead box classO1 Transcription factors." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-B64B-C.

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30

Ganjam, Goutham Kumar [Verfasser]. "Regulation of rat liver glucokinase gene expression by sterol regulatory element binding protein-1a and forkhead box classO1 transcription factors / vorgelegt von Goutham Kumar Ganjam." 2008. http://d-nb.info/993419305/34.

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31

Tsai, Kuang-Lei, та 蔡光磊. "Structural and functional studies of the protein-DNA complex: (一)Structural study of human forkhead transcriptional factor FOXO3a bound to DNA (二)Structural and functional studies of replicative helicase and helicase loader". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/23107892814106251723.

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博士<br>國立清華大學<br>生物資訊與結構生物研究所<br>98<br>Structural study of human forkhead transcriptional factor FOXO3a bound to DNA Abstract FOXO3a is a transcription factor of the FOXO family. The FOXO proteins participate in multiple signaling pathways, and their transcriptional activity is regulated by several post-translational mechanisms, including phosphorylation, acetylation, and ubiquitination. Because these post-translational modification sites are located at the C-terminal basic region of the FOXO DNA-binding domain, it is possible that these post-translational modifications could alter the DNA-bind

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32

Trowitzsch, Simon. "Functional and structural investigation of spliceosomal snRNPs." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AD28-3.

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