Relevant bibliographies by topics / Forkhead Transcription Factors – metabolism

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Forkhead Transcription Factors – metabolism'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "Forkhead Transcription Factors – metabolism"

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Wijchers, Patrick J. E. C., J. Peter H. Burbach, and Marten P. Smidt. "In control of biology: of mice, men and Foxes." Biochemical Journal 397, no. 2 (June 28, 2006): 233–46. http://dx.doi.org/10.1042/bj20060387.

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Forkhead proteins comprise a highly conserved family of transcription factors, named after the original forkhead gene in Drosophila. To date, over 100 forkhead genes have been identified in a large variety of species, all sharing the evolutionary conserved ‘forkhead’ DNA-binding domain, and the cloning and characterization of forkhead genes have continued in recent years. Forkhead transcription factors regulate the expression of countless genes downstream of important signalling pathways in most, if not all, tissues and cell types. Recent work has provided novel insights into the mechanisms that contribute to their functional diversity, including functional protein domains and interactions of forkheads with other transcription factors. Studies using loss- and gain-of-function models have elucidated the role of forkhead factors in developmental biology and cellular functions such as metabolism, cell division and cell survival. The importance of forkhead transcription factors is underlined by the developmental defects observed in mutant model organisms, and multiple human disorders and cancers which can be attributed to mutations within members of the forkhead gene family. This review provides a comprehensive overview of current knowledge on forkhead transcription factors, from structural organization and regulatory mechanisms to cellular and developmental functions in mice and humans. Finally, we will discuss how novel insights gained from involvement of ‘Foxes’ in the mechanisms underlying human pathology may create new opportunities for treatment strategies.
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Carlsson, Peter, and Margit Mahlapuu. "Forkhead Transcription Factors: Key Players in Development and Metabolism." Developmental Biology 250, no. 1 (October 2002): 1–23. http://dx.doi.org/10.1006/dbio.2002.0780.

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Klotz. "FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance." Proceedings 11, no. 1 (April 16, 2019): 11. http://dx.doi.org/10.3390/proceedings2019011011.

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FOXO (Forkhead box, class O) proteins are transcriptional regulators ubiquitously expressed in mammalian cells with roles in modulating fuel metabolism, stress resistance and cell death. FOXO transcription factors are regulated by redox processes at several levels, including enzymatic and nonenzymatic posttranslational modification. Target genes controlled by FOXO proteins include genes encoding antioxidant proteins, thus likely contributing to the key role FOXOs play in the cellular response to oxidative stress. Here, an overview is provided on (i) the modulation of FOXO proteins by thiol depleting agents, (ii) consequences of thiol depletion for stress resistance and life span of a model organism, Caenorhabditis elegans and (iii) the role of FOXO proteins therein.
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van der Heide, Lars P., Frank M. J. Jacobs, J. Peter H. Burbach, Marco F. M. Hoekman, and Marten P. Smidt. "FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling." Biochemical Journal 391, no. 3 (October 25, 2005): 623–29. http://dx.doi.org/10.1042/bj20050525.

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Forkhead members of the ‘O’ class (FoxO) are transcription factors crucial for the regulation of metabolism, cell cycle, cell death and cell survival. FoxO factors are regulated by insulin-mediated activation of PI3K (phosphoinositide 3-kinase)–PKB (protein kinase B) signalling. Activation of PI3K–PKB signalling results in the phosphorylation of FoxO factors on three conserved phosphorylation motifs, which are essential for the translocation of FoxO factors from the nucleus to the cytosol. FoxO6, however, remains mostly nuclear due to the fact that its shuttling ability is dramatically impaired. FoxO1, FoxO3 and FoxO4 all contain an N- and C-terminal PKB motif and a motif located in the forkhead domain. FoxO6 lacks the conserved C-terminal PKB motif, which is the cause of the shuttling impairment. Since FoxO6 can be considered constitutively nuclear, we investigated whether it is also a constitutively active transcription factor. Our results show that FoxO6 transcriptional activity is inhibited by growth factors, independent of shuttling, indicating that it is not constitutively active. The PKB site in the forkhead domain (Ser184) regulated the DNA binding characteristics and the N-terminal PKB site acted as a growth factor sensor. In summary, FoxO6 is not a constitutively active transcription factor and can be regulated by growth factors in a Thr26- and Ser184-dependent manner, independent of shuttling to the cytosol.
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Farhan, Mohd, Marta Silva, Xing Xingan, Yu Huang, and Wenhua Zheng. "Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis." Cells 9, no. 7 (June 30, 2020): 1586. http://dx.doi.org/10.3390/cells9071586.

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Forkhead box O transcription factors (FOXOs) regulate several signaling pathways and play crucial roles in health and disease. FOXOs are key regulators of the expression of genes involved in multiple cellular processes and their deregulation has been implicated in cancer. FOXOs are generally considered tumor suppressors and evidence also suggests that they may have a role in the regulation of cancer metabolism and angiogenesis. In order to continue growing and proliferating, tumor cells have to reprogram their metabolism and induce angiogenesis. Angiogenesis refers to the process of new blood capillary formation from pre-existing vessels, which is an essential driving force in cancer progression and metastasis through supplying tumor cells with oxygen and nutrients. This review summarizes the roles of FOXOs in the regulation of cancer metabolism and angiogenesis. A deeper knowledge of the involvement of FOXOs in these two key processes involved in cancer dissemination may help to develop novel therapeutic approaches for cancer treatment.
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Wang, Yu, Yanmin Zhou, and Dana T. Graves. "FOXO Transcription Factors: Their Clinical Significance and Regulation." BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/925350.

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Members of the class O of forkhead box transcription factors (FOXO) have important roles in metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is tightly regulated by posttranslational modification, including phosphorylation, acetylation, and ubiquitylation. Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein kinase phosphorylates FOXOs at different sites which regulate FOXOs nuclear localization or degradation. FOXO transcription factors are upregulated in a number of cell types including hepatocytes, fibroblasts, osteoblasts, keratinocytes, endothelial cells, pericytes, and cardiac myocytes. They are involved in a number of pathologic and physiologic processes that include proliferation, apoptosis, autophagy, metabolism, inflammation, cytokine expression, immunity, differentiation, and resistance to oxidative stress. These processes impact a number of clinical conditions such as carcinogenesis, diabetes, diabetic complications, cardiovascular disease, host response, and wound healing. In this paper, we focus on the potential role of FOXOs in different disease models and the regulation of FOXOs by various stimuli.
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Mondeel, Thierry D. G. A., Petter Holland, Jens Nielsen, and Matteo Barberis. "ChIP-exo analysis highlights Fkh1 and Fkh2 transcription factors as hubs that integrate multi-scale networks in budding yeast." Nucleic Acids Research 47, no. 15 (July 12, 2019): 7825–41. http://dx.doi.org/10.1093/nar/gkz603.

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AbstractThe understanding of the multi-scale nature of molecular networks represents a major challenge. For example, regulation of a timely cell cycle must be coordinated with growth, during which changes in metabolism occur, and integrate information from the extracellular environment, e.g. signal transduction. Forkhead transcription factors are evolutionarily conserved among eukaryotes, and coordinate a timely cell cycle progression in budding yeast. Specifically, Fkh1 and Fkh2 are expressed during a lengthy window of the cell cycle, thus are potentially able to function as hubs in the multi-scale cellular environment that interlocks various biochemical networks. Here we report on a novel ChIP-exo dataset for Fkh1 and Fkh2 in both logarithmic and stationary phases, which is analyzed by novel and existing software tools. Our analysis confirms known Forkhead targets from available ChIP-chip studies and highlights novel ones involved in the cell cycle, metabolism and signal transduction. Target genes are analyzed with respect to their function, temporal expression during the cell cycle, correlation with Fkh1 and Fkh2 as well as signaling and metabolic pathways they occur in. Furthermore, differences in targets between Fkh1 and Fkh2 are presented. Our work highlights Forkhead transcription factors as hubs that integrate multi-scale networks to achieve proper timing of cell division in budding yeast.
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van der HEIDE, Lars P., Marco F. M. HOEKMAN, and Marten P. SMIDT. "The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation." Biochemical Journal 380, no. 2 (June 1, 2004): 297–309. http://dx.doi.org/10.1042/bj20040167.

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FoxO (forkhead box O; forkhead members of the O class) are transcription factors that function under the control of insulin/insulin-like signalling. FoxO factors have been associated with a multitude of biological processes, including cell-cycle, cell death, DNA repair, metabolism and protection from oxidative stress. Central to the regulation of FoxO factors is a shuttling system, which confines FoxO factors to either the nucleus or the cytosol. Shuttling of FoxO requires protein phosphorylation within several domains, and association with 14-3-3 proteins and the nuclear transport machinery. Description of the FoxO-shuttling mechanism contributes to the understanding of FoxO function in relation to signalling and gene regulation.
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FOUFELLE, Fabienne, and Pascal FERRÉ. "New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c." Biochemical Journal 366, no. 2 (September 1, 2002): 377–91. http://dx.doi.org/10.1042/bj20020430.

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The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels, including a transcriptional level, since many of the metabolism-related genes are expressed according to the quantity and quality of nutrients. Recent advances have been made in the understanding of the regulation of hepatic glycolytic, lipogenic and gluconeogenic gene expression by pancreatic hormones, insulin and glucagon and glucose. Here we review the role of the transcription factors forkhead and sterol regulatory element binding protein-1c in the inductive and repressive effects of insulin on hepatic gene expression, and the pathway that leads from glucose to gene regulation with the recently discovered carbohydrate response element binding protein. We discuss how these transcription factors are integrated in a regulatory network that allows a fine tuning of hepatic glucose storage or production, and their potential importance in metabolic diseases.
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Murtaza, Ghulam, Abida Kalsoom Khan, Rehana Rashid, Saiqa Muneer, Syed Muhammad Farid Hasan, and Jianxin Chen. "FOXO Transcriptional Factors and Long-Term Living." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/3494289.

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Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.
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Dissertations / Theses on the topic "Forkhead Transcription Factors – metabolism"

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St-Pierre, Jessica. "The role of CD4⁺ Foxp3⁺ naturally-occurring regulatory T cells in the host immune response to Plasmodium chabaudi AS /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111941.

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Naturally-occurring CD4+Foxp3+ regulatory T cells (nTreg) play a central role in maintaining immune self-tolerance as well as modulating immunity towards pathogens. Pathogens may establish chronic infections in immunocompetent hosts by engaging nT reg in order to promote immunosuppression. The goal of the research described here is to test the hypothesis that nTreg modulate protective immunity to malaria, and consequentially affect susceptibility to the parasite. To investigate this question, the functional dynamics of CD4+Foxp3 + nTreg cells were evaluated in mice infected with blood-stage Plasmodium chabaudi AS. Adoptive transfer of nTreg to infected wild-type C57BL/6 (B6) mice or infection of transgenic B6 mice over-expressing Foxp3 resulted in increased parasitemia and reduced survival compared to control mice. Moreover, while resistant B6 mice exhibited decreased splenic nT reg frequencies at day 7 post infection, susceptible A/J mice maintained high numbers of nTreg at this time. Investigation of the effects of nTreg regulation on immune cell function in P. chabaudi AS-infected mice revealed that increased nTreg frequencies led to decreased malaria-specific lymphoproliferation and increased systemic levels of IL-10. Unlike B6 mice, increased splenic nTreg frequencies in infected A/J mice correlated with decreased effector T cell proliferation and IFN-gamma secretion, decreased B cell and NK cell proliferation as well as deficient IFN-gamma secretion by NK cells. Finally, nTreg proliferated within infected sites in both B6 and A/J mice, albeit to a greater extent in susceptible A/J mice. Altogether, these results demonstrate that nTreg suppressed anti-malarial immunity, and in turn promoted parasite growth and persistence.
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Greberg, Maria Hellqvist. "Cloning and characterization of FREACs, human forkhead transcription factors." Göteborg : Dept. of Cell and Molecular Biology, Göteborg University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751934.html.

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Chen, Xi. "The DNA-binding specificity of forkhead transcription factors." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-dnabinding-specificity-of-forkhead-transcription-factors(bc02fd29-30d0-47da-9b4f-448687504463).html.

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The healthy development of a living cell requires precise spatial-temporal gene expression. The code that dictates when and where genes are expressed is stored in a pattern of specific sequence motifs, which can be recognised by transcription factors. Understanding the interaction between these DNA sequence motifs and transcription factors will help to elucidate how genomic sequences build transcriptional control networks. However, the DNA-binding specificities of ~1400 human transcription factors are largely unknown. The in vivo DNA-binding events of transcription factors involve great subtlety, because most transcription factors recognise degenerate sequence motifs and related transcription factors often prefer similar or even identical sequences. Forkhead transcription factors exemplify these challenges. To understand how members within the Forkhead transcription factor family gain their binding and functional specificities, we used chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) to interrogate the genome-wide chromatin binding events of three Forkhead transcription factors: FOXM1, FOXO3 and FOXK2. We find that FOXM1 specifically binds to the promoters of a large array of genes whose activities peak at the G2 and M phases of the cell cycle. The canonical Forkhead consensus GTAAACA is not enriched within the FOXM1 cistrome. It gains its own specific binding events and biological functions by interacting and cooperating with the MMB complex. FOXO3 and FOXK2 are recruited to chromatin by the canonical Forkhead consensus GTAAACA, and they bind both shared and specific regions in the genome. FOXO3 mostly binds to the regions which are also bound by FOXK2, but no competitive or assisted binding between FOXO3 and FOXK2 is detected within those regions. Overall, these results help explain how individual members of the Forkhead transcription factor family gain binding specificity within the genome yet raises new questions of how functional specificity is achieved by other family members.
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何明孝 and Ming-how Ho. "Sequence variation and covariation in forkhead domains." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970552.

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Ho, Ming-how. "Sequence variation and covariation in forkhead domains." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25155283.

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Karadedou, Christina Theano. "Forkhead transcription factors in the regulation of VEGF in breast cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7113.

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High levels of the major angiogenic factor VEGF, have been reported in a number of cancer cell lines and in clinical specimens derived from breast. The forkhead transcription factors important for the regulation of many different physiological processes have been implicated in VEGF regulation in breast cancer. In this study, we have shown the interplay between FOXO3a and FOXM1 in breast cancer, with FOXO3a acting as a direct transcriptional repressor of VEGF. The mode of action of FOXO3a on the promoter of VEGF is dictated by events such as the competition with the VEGF transcriptional activator FOXM1, and the subsequent recruitment of a FOXO3a/HDAC2 complex on the exact binding site. This action results in the repression of VEGF transcription and the decrease of VEGF expression and cell migration. Mutating the putative forkhead responsive element affects promoter activity, and silencing FOXO3a results in up-regulation of VEGF expression. Apart overexpression of FOXO3a also results in the repression of FOXM1 expression, by its direct binding to the FOXM1 promoter. This event is also involved, indirectly, in the regulation of VEGF repression. Apart from FOXO3a and FOXM1, two other forkhead transcription factors that are implicated in breast cancer, FOXA1 and FOXC2, are also involved in the regulation of VEGF. FOXA1, a good prognosis factor in breast cancer, seems to inhibit the expression of FOXC2, a poor prognosis factor. FOXA1 is directly recruited on its binding site of the FOXC2 promoter, affecting its transcription and conferring a significantly low expression. Silencing FOXA1 results in high FOXC2 protein levels. The mode of action of these two factors between them affects the expression of VEGF. These findings provide information on the cross-talk between different forkhead transcription factors and a crucial factor of tumour migration, invasion, angiogenesis and metastasis.
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Lopes, Jared Emery. "Amino terminal region of FOXP3 coordinates the regulation of transcriptional targets in regulatory and effector T cell lineages /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8354.

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Stavrou, Emmanouil. "Regulation of FOXO transcription factors by gonadotropin-releasing hormone." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5686.

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G protein-coupled receptors (GPCRs) are a large family of trans-membrane receptors that transmit signals from extracellular stimuli to target intracellular signal transduction pathways. The gonadotropin-releasing hormone receptor (GnRH-R) is a GPCR which binds the decapeptide GnRH. In the pituitary gonadotrope, GnRH stimulates gonadotropin (LH and FSH) biosynthesis and secretion to regulate reproduction. GnRH and the GnRH-Rs are also present in many extra-pituitary tissues, although their role at these sites remains largely undetermined. GnRH-Rs are known to recruit a diverse array of signalling pathway mediators in different cell-types. These include; Gq/11-PLCβ-IP3/DAG-Ca2+/PKC signalling, monomeric G-proteins and integrins to mediate cell adhesion and migration, the activation of the major members of the mitogen-activated protein kinase (MAPK) super-family (extracellular signal-regulated kinase (ERK), c-Jun N-terminal Kinase (JNK) and p38MAPK), and β-catenin and other mediators of the canonical Wnt signalling pathway. This thesis describes the regulation of Forkhead Box O (FOXO) transcription factors by GnRH. The mammalian FOXO transcription factors, FOXO1, FOXO3a and FOXO4, are emerging as an important family of proteins that modulate the expression of genes involved in cell-cycle regulation, induction of apoptosis, DNA damage repair and response to oxidative stress. In this thesis, emphasis is placed on delineating the novel role of FOXO transcription factors in mediating two important and widely-researched areas of GnRH biology. Firstly, the role of FOXO transcription factors in mediating cell-growth inhibition in response to GnRH treatment is assessed in a heterologous HEK293/GnRH-R expressing cell line. Secondly, the role of transcription factors in regulating luteinising hormone-β (LHβ)-subunit expression is investigated in the LβT2 gonadotrope cell line. Activation of the GnRH-R can inhibit cell proliferation and induce apoptosis in certain tumour-derived cell lines. Several studies have reported that these events can occur as a result of changes in the expression profiles of specific cell-cycle regulatory and apoptotic genes, many of which are FOXO-target genes, including GADD45, FasL, p21Cip1 and p27Kip1. In this thesis, a role for FOXOs in targeting the expression of several of these genes in response to GnRH is assessed, highlighting a specific role for FOXO3a in mediating GADD45 and FasL expression. The signalling mechanisms through which FOXO3a regulates GADD45 expression in response to GnRH is also described. Finally, a stable FOXO3a-knock-down cell line was generated in order to further examine FOXO3a involvement in GnRH-induced cell-growth inhibition. GnRH is an essential regulator of the reproductive process by stimulating the synthesis of LH and FSH in pituitary gonadotropes, thereby regulating gametogenesis and steroidogenesis. Diverse signalling pathways have been reported to regulate LHβ-subunit expression in response to GnRH, including the ERK/JNK/p38MAPK cascades and factors such as Egr1, SF1 and β-catenin. In the second part of this thesis, the role of FOXOs in regulating LHβ-subunit expression in response to GnRH is described. The data presented suggests that GnRH can regulate LHβ-subunit expression through both indirect and direct FOXO3a-mediated mechanisms. Firstly, FOXO3a was found to regulate Egr1 expression to indirectly target LHβ-promoter activity. Secondly, a role for β-catenin as a FOXO3a co-factor to directly regulate LHβ-subunit expression, together with Egr1 and SF1, is also proposed. FOXO3a expression and sub-cellular localisation was assessed and demonstrated in LβT2 cells and in adult human male pituitary sections. The research presented in this thesis adds to the diversity of signalling pathways and mediators that GnRH can target in different cellular backgrounds in order to mediate a variety of cellular processes. The antiproliferative and apoptotic effects of GnRH on tumour-derived cell lines are well-documented, and this research highlights a novel role for FOXO3a in mediating these events. The regulation of gonadotropin synthesis remains an important topic of research, and the novel implication of FOXO3a in mediating LHβ-subunit expression adds further complexity to gonadotrope physiology.
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Ching, Chi-yun Johannes, and 程子忻. "Transcriptional regulation of p16INK4a expression by the forkhead box transcription factor FOXM1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29466192.

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Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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Books on the topic "Forkhead Transcription Factors – metabolism"

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Maiese, Kenneth, ed. Forkhead Transcription Factors. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-1599-3.

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Maiese, Kenneth. Forkhead transcription factors: Vital elements in biology and medicine. New York: Springer Science+Business Media, 2009.

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Ormestad, Mattias. FoxF genes in embryonic development. Göteborg: Department of Cell and Molecular Biology, Göteborg University, 2006.

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Hedgehog-gli signaling in human disease. Georgetown, Tex: Landes Bioscience/Eurekah.com, 2006.

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Pohjanvirta, Raimo. The AH receptor in biology and toxicology. Hoboken, N.J: Wiley, 2011.

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1958-, Maiese Kenneth, ed. Forkhead transcription factors: Vital elements in biology and medicine. New York: Springer Science+Business Media, 2009.

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1958-, Maiese Kenneth, ed. Forkhead transcription factors: Vital elements in biology and medicine. New York: Springer Science+Business Media, 2009.

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Forkhead transcription factors: Vital elements in biology and medicine. New York: Springer Science+Business Media, 2009.

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Ghaffari, Saghi. Forkhead FOXO Transcription Factors in Development and Disease. Elsevier Science & Technology Books, 2018.

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Forkhead FOXO Transcription Factors in Development and Disease. Elsevier, 2018. http://dx.doi.org/10.1016/s0070-2153(18)x0002-7.

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Book chapters on the topic "Forkhead Transcription Factors – metabolism"

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Liu, Longhua, and Zhiyong Cheng. "Forkhead Box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis." In Stem Cell Biology and Regenerative Medicine, 47–69. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-98146-8_4.

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Fukunaga, Kohji, and Norifumi Shioda. "Pathophysiological Relevance of Forkhead Transcription Factors in Brain Ischemia." In Advances in Experimental Medicine and Biology, 130–42. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1599-3_10.

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Günzl, Arthur. "RNA Polymerases and Transcription Factors of Trypanosomes." In RNA Metabolism in Trypanosomes, 1–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-28687-2_1.

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Kim, Soo Young. "Transcription Factors Involved in ABA Signaling." In Abscisic Acid: Metabolism, Transport and Signaling, 225–42. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9424-4_11.

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Yang, Xiao-Feng, Pu Fang, Shu Meng, Michael Jan, Xinyu Xiong, Ying Yin, and Hong Wang. "The Forkhead Transcription Factors Play Important Roles in Vascular Pathology and Immunology." In Advances in Experimental Medicine and Biology, 90–105. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1599-3_7.

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Jögi, Annika. "Tumour Hypoxia and the Hypoxia-Inducible Transcription Factors: Key Players in Cancer Progression and Metastasis." In Tumor Cell Metabolism, 65–98. Vienna: Springer Vienna, 2015. http://dx.doi.org/10.1007/978-3-7091-1824-5_4.

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Brooks, Alan R., and Beatriz Levy-Wilson. "Three Liver-Enriched Transcription Factors: HNF-1, C/EBP, and Protein II are Required to Enhance Transcription of the Human Apolipoprotein B Gene." In Drugs Affecting Lipid Metabolism, 29–44. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1703-6_5.

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Pattanaik, Sitakanta, Joshua R. Werkman, Que Kong, and Ling Yuan. "Site-Directed Mutagenesis and Saturation Mutagenesis for the Functional Study of Transcription Factors Involved in Plant Secondary Metabolite Biosynthesis." In Plant Secondary Metabolism Engineering, 47–57. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-723-5_4.

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Ito, Yoshihisa, Kumiko Ishige, Masahiro Aizawa, and Hideomi Fukuda. "GABAB Antagonists Block γ-Butyrolactone-Induced Absence Seizures and Coordinated Induction of Transcription Factors in Mouse Brain." In GABA: Receptors, Transporters and Metabolism, 313–20. Basel: Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8990-2_35.

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Zheng, Wen-Hua, Satyabrata Kar, and Remi Quirion. "The Forkhead Family of Transcription Factors are Targets of AKT in IGF-1 Mediated Survival in Neuronal Cells." In Mapping the Progress of Alzheimer’s and Parkinson’s Disease, 217–22. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-0-306-47593-1_36.

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Conference papers on the topic "Forkhead Transcription Factors – metabolism"

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Al-Tamari, Hamza M., Matthias Eschenhagen, Anja Schmall, Rajkumar Savai, Hossein A. Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Schermuly, and Soni S. Pullamsetti. "The Role Of Forkhead Box O 3a (FoxO3a) Transcription Factors In The Pathogenesis Of Pulmonary Fibrosis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3506.

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Sannes, PL, KB Apparao, H. Zhang, J. Khosla, SH Randell, and DR Newman. "Changes in Expression of Forkhead Transcription Factors and TGF-β1 and Wnt Signaling during Differentiation of Alveolar Epithelial Cells In Vitro and in Bleomycin-Induced Fibrosis." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2404.

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Saadatzadeh, Mohammad Reza, Haiyan Wang, Jixin Ding, Barbara J. Bailey, Eva Tonsing-Carter, Shanbao Cai, Nimita Dave, Harlan E. Shannon, Aaron Cohen Gadol, and Karen E. Pollok. "Abstract A26: Inhibition of MDM2 and AKT signaling networks synergize to activate Forkhead box O-class transcription factors and promote cell death in mutant p53 GBM cells." In Abstracts: AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.brain15-a26.

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Tanaka, Noriaki, Mei Zhao, Jiexin Zhang, Jing Wang, Ge Zhou, and Jeffrey N. Myers. "Abstract 73: Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cell by targeting forkhead transcription factors FOXO3a and FOXM1." In Abstracts: AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.aacrahns17-73.

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Abdel-Sayed, Philippe, Arne Vogel, and Dominique P. Pioletti. "Dissipation Can Act as a Mechanobiological Signal in Cartilage Differentiation." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62268.

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Abstract:
Knee cartilage is a soft tissue having viscoelastic properties. Under cyclic loadings, viscoelastic materials dissipate mechanical loadings through heat generation. In knee cartilage, this heat might not be convected because of the tissue avascularity, resulting thus to a local temperature increase. As cells are sensitive to temperature, these thermo-mechanical phenomena of energy dissipation could influence their metabolism. The goal of this study is to evaluate the effect of thermogenesis on chondrogenic differentiation. First, we focused our work in quantifying the heat generated in cartilage as a result to deformation. On a cellular level, the effect of thermal alterations on cell metabolism was assessed looking at the gene expression of transcription factors involved in chondrogenesis. Hence, human chondro-progenitor cells were cultured at 33°C and 37°C for 48 h and 96 h. An up-regulation in mRNA expression levels of Sox9 and its co-activator PGC-1α has been observed. These results point to a thermal contribution to chondrogenic gene expression.
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Reports on the topic "Forkhead Transcription Factors – metabolism"

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Grotewold, Erich. Engineering phenolics metabolism in the grasses using transcription factors. Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1088660.

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