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Journal articles on the topic 'Formation of vincristine'

Author: Grafiati

Published: 6 September 2023

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1

Wawro, Marta Ewelina, Katarzyna Sobierajska, Wojciech Michał Ciszewski, and Jolanta Niewiarowska. "Nonsteroidal Anti-Inflammatory Drugs Prevent Vincristine-Dependent Cancer-Associated Fibroblasts Formation." International Journal of Molecular Sciences 20, no. 8 (2019): 1941. http://dx.doi.org/10.3390/ijms20081941.

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Vincristine is used in the clinical treatment of colon cancer, especially in patients diagnosed in the advanced phase of cancer development. Unfortunately, similar to other agents used during antitumor therapy, vincristine might induce chemoresistance. Studies of this process focus mainly on the analysis of the molecular mechanisms within cancer, usually ignoring the role of stromal cells. Our present findings confirm that vincristine stimulates the secretion of tumor growth factors class beta and interleukin-6 from cancer-associated fibroblasts as a result of paracrine stimulation by cancer c

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Moha, Rico. "Chemotherapy medication of Vincristine and Vinblastine." Cancer Research and Cellular Therapeutics 1, no. 1 (2017): 01–02. http://dx.doi.org/10.31579/2640-1053/007.

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Cancers treated with Vincristine and vinblastine include: acute leukemia, Hodgkin's and non- Hodgkin's lymphoma, neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma, Wilms' tumor, multiple myeloma, chronic leukemias, thyroid cancer, brain tumors, non-small cell lung cancer, bladder cancer, melanoma, and testicular cancer andIt is also used to treat some blood disorders. It is given by injection into a vein. Vincristine and vinblastine exhibit differential activity against tumors and normal tissues. In this work, a number of cultured cell lines were assayed for their sensitivity to the antiprolife

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Bowman, Laura C., Janet A. Houghton, and Peter J. Houghton. "Formation and stability of vincristine-tubulin complex in kidney cytosols." Biochemical Pharmacology 37, no. 7 (1988): 1251–57. http://dx.doi.org/10.1016/0006-2952(88)90778-2.

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4

Takahashi, Tsutomu, Yoshio Honma, Koshi Kawakami та Junji Suzumiya. "Cotylenin Α, a Fusicoccane Diterpene Glycoside with a Complex Sugar Moiety, and Vincristine Synergistically Inhibit the Growth of Myeloma Cell in Vitro and in Vivo". Blood 124, № 21 (2014): 5721. http://dx.doi.org/10.1182/blood.v124.21.5721.5721.

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Abstract Introduction: Multiple myeloma is still incurable and optimize existing chemotherapeutic strategies and development of novel agents are necessary to improve the outcome of patients. Cotylenin A, a fusicoccane diterpene glycoside with a complex sugar moiety, was isolated as a plant-growth regulator. Cotylenin A modulates the 14-3-3 intracellular signaling pathway and has been shown to inhibit the growth of several cancer cells. Herein, we examined the antitumor effects of cotylenin A to develop a novel treatment against myeloma. Methods: Five human myeloma cell lines, RPMI8226, KMS-11,

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Singh, Akannsha, Mariana Zapata, Yong Sung Choi, and Sun-Ok Yoon. "GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation." Cell Cycle 13, no. 1 (2013): 157–66. http://dx.doi.org/10.4161/cc.26951.

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6

Diouf, Barthelemy, Kristine Crews, Glen Lew, et al. "Genome-Wide Association Analyses Identify Susceptibility Loci For Vincristine-Induced Peripheral Neuropathy In Children With Acute Lymphoblastic Leukemia." Blood 122, no. 21 (2013): 618. http://dx.doi.org/10.1182/blood.v122.21.618.618.

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Abstract Introduction Vincristine, a vinca alkaloid, is one of the most widely used and effective medications for acute lymphoblastic leukemia (ALL). Vincristine exerts its cytotoxic effects by interfering with microtubule formation and mitotic spindle dynamics, leading to mitotic arrest and cell death. However its use often causes neuropathy characterized by abdominal pain, sensory and motor dysfunctions. To date, various candidate gene studies have failed to identify consistent genetic variants associated with an increased risk of vincristine-induced neuropathy. Methods Vincristine-induced n

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Zhang, Jiandi, Mary C. Reedy, Yusuf A. Hannun, and Lina M. Obeid. "Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis." Journal of Cell Biology 145, no. 1 (1999): 99–108. http://dx.doi.org/10.1083/jcb.145.1.99.

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During apoptosis, the cell actively dismantles itself and reduces cell size by the formation and pinching off of portions of cytoplasm and nucleus as “apoptotic bodies.” We have combined our previously established quantitative assay relating the amount of release of [3H]-membrane lipid to the degree of apoptosis with electron microscopy (EM) at a series of timepoints to study apoptosis of lymphoid cells exposed to vincristine or etoposide. We find that the [3H]-membrane lipid release assay correlates well with EM studies showing the formation and release of apoptotic bodies and cell death, and

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Liedtke, Michaela, Clare Twist, Marcia Bieber, Neelima Bhat, Nelson N. H. Teng, and Steven Coutre. "A Phase I Study of a Novel Human Monoclonal Antibody (mAb216) with Chemotherapy for the Treatment of Patients with Relapsed or Refractory B-Lineage Acute Lymphoblastic Leukemia." Blood 110, no. 11 (2007): 2831. http://dx.doi.org/10.1182/blood.v110.11.2831.2831.

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Abstract BACKGROUND: Despite improvements in front-line therapy for adult ALL, most patients eventually relapse and do not tolerate or respond to reinduction therapy. Novel targeted therapies are needed that have both activity against adult ALL and a toxicity profile distinct from conventional chemotherapy. MAb216 is a naturally occurring human IgM monoclonal antibody derived from the VH4-34 (variable heavy chain) gene. It has shown promise as a novel therapy for B-ALL in preclinical studies. In vitro, mAb216 specifically binds and is cytotoxic to normal human B-lymphocytes and B-progenitor ly

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Shah, Mithun Vinod, Karen S. Flatten, B. Douglas Smith, Allan D. Hess, and Scott H. Kaufmann. "MTH1 Inhibitor-Induced Cytotoxicity in Acute Myeloid Leukemia." Blood 126, no. 23 (2015): 1273. http://dx.doi.org/10.1182/blood.v126.23.1273.1273.

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Abstract BACKGROUND: Acute myeloid leukemia (AML) is an aggressive leukemia with 5-year overall survival of 20-25%. The major reason for treatment failure in AML is resistance to chemotherapy. Thus, there is an urgent need for identification of novel therapeutic agents for AML. Neoplastic cells, including AML, have dysfunctional redox regulation that results in increased reactive oxygen species (ROS). Accumulation of ROS leads to oxidation of free and incorporated nucleotides, leading to DNA damage and cell death. MTH1 is a nudix family hydrolase that sanitizes the oxidized nucleotide pool to

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Fine, R. L., S. Koizumi, G. A. Curt, and B. A. Chabner. "Effect of calcium channel blockers on human CFU-GM with cytotoxic drugs." Journal of Clinical Oncology 5, no. 3 (1987): 489–95. http://dx.doi.org/10.1200/jco.1987.5.3.489.

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Calcium channel blockers (CCBs) such as verapamil and nitrendipine are capable of increasing drug sensitivity in resistant murine and human tumor cells. This finding has potential value in the treatment of acquired drug resistance in human malignancies. Thus, we tested the ability of CCBs of two different structural classes to enhance the toxicity of doxorubicin (DOX), vinblastine (VBL), and vincristine (VCR) for normal myeloid and macrophage colony formation (marrow colony forming units-granulocyte-monocyte [CFU-GM]). Drug effects on colony formation from 35 normal volunteer marrows and from

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11

Ghosh, Susmita, Fan Fan, Jason Roszik, et al. "Abstract 1056: Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells." Cancer Research 82, no. 12_Supplement (2022): 1056. http://dx.doi.org/10.1158/1538-7445.am2022-1056.

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Abstract Background: Colorectal cancer (CRC) is a heterogeneous disease with various driver genetic mutations. Metastatic colorectal cancer (mCRC) is the second leading cause of cancer related deaths in the US. Greater than 50% of patients with mCRC harbor mutations in the oncogenic drivers KRAS or NRAS. While direct targeting of specific mutations in RAS is in the early stages of development in patients with mCRC, targeting most mutations in RAS is technically challenging. Hence, prior efforts have been focused on targeting MEK, a downstream mediator of RAS. Unfortunately, several MEK inhibit

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O'Neill, MA, M. Mayer, KE Murray, et al. "Does usnic acid affect microtubules in human cancer cells?" Brazilian Journal of Biology 70, no. 3 (2010): 659–64. http://dx.doi.org/10.1590/s1519-69842010005000013.

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Usnic acid, a lichen metabolite, is known to exert antimitotic and antiproliferative activities against normal and malignant human cells. Many chemotherapy agents exert their activities by blocking cell cycle progression, inducing cell death through apoptosis. Microtubules, protein structure involved in the segregation of chromosomes during mitosis, serve as chemotherapeutical targets due to their key role in cellular division as well as apoptosis. The aim of this work was to investigate whether usnic acid affects the formation and/or stabilisation of microtubules by visualising microtubules a

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Tonn, Jörg-Christian, Hans Kristian Haugland, Jaakko Saraste, Klaus Roosen, and Ole Didrik Laerum. "Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines." Journal of Neurosurgery 82, no. 6 (1995): 1035–43. http://dx.doi.org/10.3171/jns.1995.82.6.1035.

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✓ The aim of this study was to investigate the antimigratory and antiinvasive potential of vincristine sulfate (VCR) on human glioma cells and to analyze whether phenytoin (5,5-diphenylhydantoin; DPH) might act synergistically with VCR. Vincristine affects the cytoplasmic microtubules; DPH has been reported to enhance VCR cytotoxicity in murine cells. In two human glioma cell lines, GaMG and D-37MG, we found VCR to reduce monolayer growth and colony formation in a dose-dependent fashion at concentrations of 10 ng/ml and above. Phenytoin increased the cytotoxic and cystostatic effects of VCR in

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14

Liu, Hui-wen, Chadwick B. Smith, Mark S. Schmidt, et al. "Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration." Proceedings of the National Academy of Sciences 115, no. 42 (2018): 10654–59. http://dx.doi.org/10.1073/pnas.1809392115.

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Axon degeneration, a hallmark of chemotherapy-induced peripheral neuropathy (CIPN), is thought to be caused by a loss of the essential metabolite nicotinamide adenine dinucleotide (NAD+) via the prodegenerative protein SARM1. Some studies challenge this notion, however, and suggest that an aberrant increase in a direct precursor of NAD+, nicotinamide mononucleotide (NMN), rather than loss of NAD+, is responsible. In support of this idea, blocking NMN accumulation in neurons by expressing a bacterial NMN deamidase protected axons from degeneration. We hypothesized that protection could similarl

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15

Leven, RM, and MK Yee. "Megakaryocyte morphogenesis stimulated in vitro by whole and partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation." Blood 69, no. 4 (1987): 1046–52. http://dx.doi.org/10.1182/blood.v69.4.1046.1046.

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Abstract Isolated guinea pig megakaryocytes were cultured in the presence of plasma from normal or thrombocytopenic rabbits. Thrombocytopenic but not normal plasma stimulated formation of long cytoplasmic processes and cytoplasmic fragmentation. Activity was found in the 60% to 80% ammonium sulfate fraction of thrombocytopenic plasma but not in the 0% to 60% fraction. The 60% to 80% fraction of normal plasma contained a small amount of activity. Both colchicine and vincristine inhibited the morphogenesis stimulated by thrombocytopenic plasma. Cytochalasin B and D both mimicked the thrombocytop

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Leven, RM, and MK Yee. "Megakaryocyte morphogenesis stimulated in vitro by whole and partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation." Blood 69, no. 4 (1987): 1046–52. http://dx.doi.org/10.1182/blood.v69.4.1046.bloodjournal6941046.

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Isolated guinea pig megakaryocytes were cultured in the presence of plasma from normal or thrombocytopenic rabbits. Thrombocytopenic but not normal plasma stimulated formation of long cytoplasmic processes and cytoplasmic fragmentation. Activity was found in the 60% to 80% ammonium sulfate fraction of thrombocytopenic plasma but not in the 0% to 60% fraction. The 60% to 80% fraction of normal plasma contained a small amount of activity. Both colchicine and vincristine inhibited the morphogenesis stimulated by thrombocytopenic plasma. Cytochalasin B and D both mimicked the thrombocytopenic plas

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17

Willingham, M. C. "Apoptosis And Resistance To Anti-Microtubule Agents." Microscopy and Microanalysis 4, S2 (1998): 1036–37. http://dx.doi.org/10.1017/s1431927600025307.

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Several clinically important anti-cancer agents exert their effects on tumor cells through interference with the function of microtubules. In addition to the Vinca alkaloids, such as vinblastine and vincristine, the taxanes, such as paclitaxel (Trade Name: Taxol), kill tumor cells through a microtubular target. Treatment with taxol leads to the inability of microtubules to depolymerize, leading to the formation of large intracellular microtubular bundles. In tumor cells that progress through the cell cycle, this leads to the inability of these cells to disassembly interphase microtubule networ

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18

Bobrova, N. F., T. A. Sorochinskaya, S. A. Tronina, and A. Y. Bratishko. "New method of salvage retinoblastoma treatment." Modern technologies in ophtalmology, no. 1 (May 29, 2021): 215–20. http://dx.doi.org/10.25276/2312-4911-2021-1-215-220.

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Purpose. Elaboration of the new method of salvage retinoblastoma (RB) treatment, combining local and systemic chemotherapy. Material and methods. Salvage treatment using the new method was carried out in 71 children aged 2 months – 7 years on 102 eyes with RB in T1–T3 stages. At the Department of Pediatric Ophthalmopathology of SI «The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine» the method of combined polychemotherapy (CPCT) was developed in 2010: primary IViC – injection of 0,01 µg (0,1 µg) Melphalan through pars plana; a course of CEV-protocol (drugs combination:

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19

Pui, C. H., C. M. Chesney, J. Weed, and C. W. Jackson. "Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia." Journal of Clinical Oncology 3, no. 9 (1985): 1266–72. http://dx.doi.org/10.1200/jco.1985.3.9.1266.

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Eleven consecutive leukemia patients with thrombosis induced by asparaginase-prednisone-vincristine therapy were studied to gain insight into the pathogenesis of this complication. Measurement of anti-thrombin III, plasminogen, factor V, and fibrin degradation products as well as platelet aggregation sensitivity to adenosine diphosphate disclosed no consistent abnormalities that would explain pathologic thrombus formation. A decrease in platelet counts observed in nine of 11 patients, prompted us to investigate the possible involvement of factor VIII in this disorder. Levels of factor VIII pro

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Qu, Yang, Michael L. A. E. Easson, Jordan Froese, Razvan Simionescu, Tomas Hudlicky, and Vincenzo De Luca. "Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast." Proceedings of the National Academy of Sciences 112, no. 19 (2015): 6224–29. http://dx.doi.org/10.1073/pnas.1501821112.

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Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only accumulate in trace amounts in C. roseus leaves. Vinblastine and vincristine are condensed from the monoterpenoid indole alkaloid (MIA) precursors catharanthine and vindoline. Although catharanthine biosynthesis remains poorly characterized, the biosynthesis of vindoline from the MIA precursor tabersonine is

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Taya, Yuji, Astushi Sato, Kaori Sato, and Takaaki Aoba. "Morphological changes in rat incisor ameloblasts after a single injection of vincristine. Sub-ameloblastic cyst formation at the late-maturation stage." Japanese Journal of Oral Biology 37, no. 1 (1995): 50–57. http://dx.doi.org/10.2330/joralbiosci1965.37.50.

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GAO, Lei, Li CHEN, Xin-hong FEI, Hui-ying QIU, Hong ZHOU, and Jian-min WANG. "STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model." Chinese Medical Journal 119, no. 11 (2006): 911–18. http://dx.doi.org/10.1097/00029330-200606010-00006.

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Sedeeq, Mohammed, Ahmed Maklad, Nuri Gueven, and Iman Azimi. "Development of a High-throughput Agar Colony Formation Assay to Identify Drug Candidates against Medulloblastoma." Pharmaceuticals 13, no. 11 (2020): 368. http://dx.doi.org/10.3390/ph13110368.

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Medulloblastoma (MB) is the most common malignant childhood brain cancer. High-risk MB tumours have a high incidence of metastasis and result in poor patient survival. Drug screens, commonly used to identify potential novel therapeutic agents against MB, focus on 2D cell proliferation and viability assays given that these assays are easily adaptable to high-throughput regimes. However, 2D models fail to address invasive characteristics that are crucial to MB metastasis and are thus not representative of tumour growth in vivo. In this study, we developed a 3D 384-well agar colony formation assa

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Moreira, Thaís de Almeida, Talita Cristina Modesto, Ana Carla da Silva Corrêa, Luciano Francisco de Maria, Rafael Rocha de Souza, and Marcio de Barros Bandarra. "Subcutaneous transmissible venereal tumor – case report." Clínica Veterinária XXI, no. 122 (2016): 46–54. http://dx.doi.org/10.46958/rcv.2016.xxi.n.122.p.46-54.

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Transmissible venereal tumor (TVT) is a specific cancer of the canine species that usually affects the genital region. Metastases occur by hematogenous or lymphatic routes. The extragenital form is rare and the cutaneous form is reported to be a warty proliferative lesion of ulcerated and friable surface, which usually presents itself concomitantly to the genital form of the disease. We hereby report a case of subcutaneous TVT in a mixed-breed neutered female, in order to contribute clinical and cytopathological data, as well as prognosis, due to unusual presentation of this neoplasm. The form

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Benning, V. M., M. B. Maratrat, E. C. Fournier, C. P. Melcion, and A. C. Cordier. "Flow cytometric detection of erythropoietic cytotoxicity in mouse bone marrow." Journal of Histochemistry & Cytochemistry 39, no. 1 (1991): 15–21. http://dx.doi.org/10.1177/39.1.1701186.

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Erythroblast proliferation and maturation in bone marrow are the processes leading to the formation of polychromatic erythrocytes (PE) and normochromatic erythrocytes (NE), respectively. PE contain RNA but no DNA, and can therefore be distinguished both from NE (which lack both RNA and DNA) and from nucleated cells (which contain both DNA and RNA). Cytotoxic agents that induce impairment of the maturation process change the PE:NE ratio. We have developed a simple and rapid method of determining the PE:NE ratio, based on flow cytometric analysis of formaldehyde-fixed, acridine orange (AO)-stain

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Zhang, Yu, Masuo Goto, Akifumi Oda, et al. "Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization." Molecules 24, no. 7 (2019): 1256. http://dx.doi.org/10.3390/molecules24071256.

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Monoterpenoid indole alkaloids are structurally diverse natural products found in plants of the family Apocynaceae. Among them, vincristine and its derivatives are well known for their anticancer activity. Bousigonia mekongensis, a species in this family, contains various monoterpenoid indole alkaloids. In the current study, fourteen known aspidosperma-type monoterpenoid indole alkaloids (1–14) were isolated and identified from a methanol extract of the twigs and leaves of B. mekongensis for the first time. Among them, compounds 3, 6, 9, and 13 exhibited similar antiproliferative activity spec

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Sayani, Farzana A., and Charles S. Abrams. "How I treat refractory thrombotic thrombocytopenic purpura." Blood 125, no. 25 (2015): 3860–67. http://dx.doi.org/10.1182/blood-2014-11-551580.

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Abstract Acquired thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA) without an obvious cause, and may include fever, mild renal failure, and neurologic deficits. It is characterized by a deficiency of the von Willebrand factor (VWF) cleaving enzyme, ADAMTS13 (a disintegrin and metalloproteinase, with a thrombospondin type 1 motif, member 13), resulting in formation of microthrombi in the high sheer environment of the microvasculature. This causes microvascular occlusion, MAHA, and organ ischemia. Diagnosis is based on th

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Ariad, Samuel, Daniel Benharroch, Lilliana Lupu, Batya Davidovici, Nicolas Dupin, and Chris Boshoff. "Early Peripheral Lymph Node Involvement of Human Herpesvirus 8–Associated, Body Cavity–Based Lymphoma in a Human Immunodeficiency Virus–Negative Patient." Archives of Pathology & Laboratory Medicine 124, no. 5 (2000): 753–55. http://dx.doi.org/10.5858/2000-124-0753-eplnio.

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Abstract Human herpesvirus 8 (HHV-8), or Kaposi sarcoma–associated herpesvirus , is a gamma herpesvirus first detected in a specimen of Kaposi sarcoma from a human immunodeficiency virus (HIV)–positive patient. Human herpesvirus 8 is also found in an unusual clinicopathologic form of body cavity–based B-cell lymphoma, which has been named primary effusion lymphoma (PEL) and occurs primarily in HIV-positive patients. PEL is characterized by the formation of lymphomatous effusions, without obvious lymphadenopathy, tumor masses, or bone marrow involvement. Only a few cases of PEL in HIV-seronegat

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Wollina, Uwe, Gesina Hansel, Dana Langner, André Koch, Jacqueline Schönlebe, and Georgi Tchernev. "Rapid Evolving Unilateral Indurated Oozing Facial Plaques in a Patient with Head-and-Neck Cancer: Peripheral T-Cell Lymphoma Not Otherwise Specified (NOS)." Open Access Macedonian Journal of Medical Sciences 5, no. 4 (2017): 476–79. http://dx.doi.org/10.3889/oamjms.2017.085.

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BACKGROUND: The sudden development of facial plaques and nodules may be an alarming clinical sign for underlying malignancies. Nevertheless, a broad range of inflammatory and infectious diseases must be considered as well in the differential diagnosis.CASE REPORT: We report on a 53-year-old male patient with a left-sided cheek infiltration with oozing but no lymphadenopathy. He had a medical history of head-and-neck cancer. The primary differential diagnosis was herpes zoster with secondary impetiginization or pyoderma facial. About eight weeks later, the patient presented with progressive for

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Kaneko, Rena, Hiroyuki Mitomi, Natsuko Nakazaki, Yuichiro Yano, Masazumi Ogawa, and Yuzuru Sato. "Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis." Journal of Gastrointestinal and Liver Diseases 26, no. 3 (2017): 299–304. http://dx.doi.org/10.15403/jgld.2014.1121.263.eko.

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Background: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT.Case presentation: A 73-year-old man presented with obstructive jaundice and a pancreatic head mass. Histology of the mass revealed chronic pancreatitis with lymphoid follicle formation, leading to a diagnosis of a suspicion of follicular pancreatitis. After a choledochojejunostomy, a hepatic tumor was detected, and a biopsy revealed lymphoplasmacyti

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Ignjatovic, Mile, Mihailo Bezmarevic, and Snezana Cerovic. "Solitary extramedullary plasmacytoma of the duodenum and pancreas: A case report and review of the literature." Vojnosanitetski pregled 73, no. 4 (2016): 402–7. http://dx.doi.org/10.2298/vsp141031142i.

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Introduction. The extramedullary plasmacytomas (EMPs) are rare tumors of plasma cell disorders which are rarely found in the duodenum. We presented a case of solitary EMPs involving the duodenum and pancreas successfully treated by surgical resection after failure of chemotherapy. Case report. A 55-year-old female with previously diagnosed solitary EMP of the duodenum was admitted to our institution after failure of three cycles of vincristine, adriablastine, dexamethasone (VAD) chemotherapy regimen with an upper gastrointestinal obstruction. On admission computed tomography of the abdomen sho

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Dai, Guang Zhi, Wen Bo Han, Ya Ning Mei, et al. "Pyridoxal-5′-phosphate–dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi." Proceedings of the National Academy of Sciences 117, no. 2 (2019): 1174–80. http://dx.doi.org/10.1073/pnas.1914777117.

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Indolizidine alkaloids such as anticancer drugs vinblastine and vincristine are exceptionally attractive due to their widespread occurrence, prominent bioactivity, complex structure, and sophisticated involvement in the chemical defense for the producing organisms. However, the versatility of the indolizidine alkaloid biosynthesis remains incompletely addressed since the knowledge about such biosynthetic machineries is only limited to several representatives. Herein, we describe the biosynthetic gene cluster (BGC) for the biosynthesis of curvulamine, a skeletally unprecedented antibacterial in

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ZHANG, Jiandi, Timothy A. DRISCOLL, Yusuf A. HANNUN, and Lina M. OBEID. "Regulation of membrane release in apoptosis." Biochemical Journal 334, no. 2 (1998): 479–85. http://dx.doi.org/10.1042/bj3340479.

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Apoptosis is a fundamental process of cell regulation whereby cells execute one or more biochemical programs leading to cell death. Several mechanisms have been evaluated and suggested to play roles in the regulation of apoptosis, including the activation of phospholipase A2 (PLA2), usually measured as release of 3H-labelled arachidonic acid (AA) from prelabelled cells. The current study was aimed at examining the role of PLA2 in regulating apoptosis in response to several inducers (such as vincristine and etoposide) in lymphoid cell lines. Cells were labelled with [3H]fatty acids and the rele

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Rys, Ryan N., Maanasa Venkataraman, Jibin Zeng, Koren Kathleen Mann, and Nathalie Johnson. "Fas Mutations in Non-Hodgkin's Lymphoma (NHL): Implications for Disease Progression and Therapeutic Resistance." Blood 134, Supplement_1 (2019): 1520. http://dx.doi.org/10.1182/blood-2019-130602.

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Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma and standard frontline treatment is carried out with R-CHOP chemotherapy. However, DLBCL remains an extremely heterogenous disease and refractory/relapse events are common. Recent sequencing experiments have found 18% of relapsed DLBCL contains Fas mutations, an increase from mutations seen at initial diagnosis. Fas receptor (FasR) is a transmembrane protein encoded by the Fas gene that is critical for the induction of extrinsic apoptosis. Once FasR is bound by Fas Ligand expressed on cytotoxic T cells,

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Ma, Jing-Xin, Hong Li, Xiao-Xin Cheng, et al. "Inhibition of SIRT1 Transcription in Resveratrol-differentiated Medulloblastoma Cells." Functional Foods in Health and Disease 3, no. 5 (2013): 154. http://dx.doi.org/10.31989/ffhd.v3i5.56.

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Backgrounds: Medulloblastoma (MB) is the commonest brain malignancy in childhood with poor prognosis, because of its rapid aggressive growth and frequent occurrence. The current chemotherapeutic regimens for medulloblastoma patients involve a combination of lomustine, cisplatin, carboplatin, vincristine or cyclophosphamide, which have distinct short- and long-term side-effects. It is therefore in urgent need to explore safer and more effective adjuvant approach(s). Resveratrol, a polyphenol rich in numerous plants, has multiple biological activities including anticancer effects. Our previous d

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Kovtun, O. P., O. V. Koryakina, V. V. Bazarnyi, and L. G. Fechina. "CLINICAL AND DIAGNOSTIC VALUE OF THE CYTOKINE PROFILE IN BLOOD PLASMA AND CEREBROSPINAL FLUID IN CHILDREN WITH VINCRISTIN-INDUCED PERIPHERAL NEUROPATHY IN ACUTE LYMPHOBLASTIC LEUKEMIA." Pediatria. Journal named after G.N. Speransky 101, no. 3 (2022): 134–42. http://dx.doi.org/10.24110/0031-403x-2022-101-3-134-142.

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Vincristine-induced peripheral neuropath (VIPN) is the main neurotoxic complication in the treatment of acute lymphoblastic leukemia (ALL) in children. The mechanisms for peripheral nerve system injury are not fully understood, rand recent studies have shown the involvement of the immune system. Objective of the study: to determine the cytokine profiles in blood plasma and cerebrospinal fluid in children with ALL and determine their relationship with the formation of VIPN. Materials and methods of research: 65 patients aged 3–17 years with ALL participated in a single-center prospective observ

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Herrera-Gonzalez, Sarahi, Dema Shamoon, Tingliang Shen, Simon Badin, and Yatinder Bains. "A Unique Case of Mantle Cell Lymphoma Masquerading as a Cecal Mass." Case Reports in Gastrointestinal Medicine 2021 (September 10, 2021): 1–5. http://dx.doi.org/10.1155/2021/5581043.

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Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin’s lymphoma, is a rare and aggressive disease with a poor prognosis due to its advanced presentation at diagnosis. It is characterized by a translocation in the Bcl-1 gene, which results in overexpression of cyclin D1. MCL is frequently seen in the form of multiple lymphomatous polyposis (MLP) in which innumerable polyps are observed in the gastrointestinal (GI) tract. In rare instances, MCL presents a single mass. The most common presentation involves male patients in their sixties, with generalized lymphadenopathy, extranodal involvemen

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Shimizu, Naomi, Shouko Nakamura, Naoyuki Kawagoe, et al. "Rituximab (R)-CHOP Therapy Has Progressed Arteriosclerosis with an Elevation of Von Willebrand Factor (vWF) in Patients with Malignant Lymphoma." Blood 132, Supplement 1 (2018): 5380. http://dx.doi.org/10.1182/blood-2018-99-112326.

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Abstract Introduction : An increased incidence of arteriosclerosis has been noted in cancer survivors. Until now, only a few reports have been reported on relationship between arteriosclerosis and chemotherapy. As a mechanism for developing arteriosclerosis by chemotherapy, reduction of nitric oxide from endothelial cells has been reported. We have reported a case who was 68-year-old female with follicular lymphoma, clinical stage IVA showing the plaque formation of carotid artery and the elevation of cardio-ankle vascular index (CAVI) after eight courses of R-CHOP therapy (rituximab, cyclopho

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Ali, Shamsher, Eric Hénon, Ritchy Leroy, and Georges Massiot. "Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations." Molecules 26, no. 21 (2021): 6395. http://dx.doi.org/10.3390/molecules26216395.

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Vindoline and catharanthine are the major alkaloids of Catharanthus roseus and are extracted in large quantities to prepare the pharmaceutically important Vinca type alkaloids vincaleukoblastine, vincristine and navelbine. The higher yield of vindoline relative to catharanthine makes it an attractive substrate for developing new chemistry and adding value to the plant. In this context, we have reacted vindoline with a selection of electrophiles among which benzoquinone. Conditions were developed to optimize the synthesis of a mono-adduct, of five bis-adducts, and of tri-adducts and tetra-adduc

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Romagnoli, Mathilde, Regis Bataille, and Sophie Barillé-Nion. "The Critical Role of Survivin in the Survival and Proliferation of Human Myeloma Cells." Blood 106, no. 11 (2005): 110. http://dx.doi.org/10.1182/blood.v106.11.110.110.

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Abstract Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells with an enhanced proliferation and survival capacity within the bone marrow. Myeloma cells often develop drug resistance leading to treatment failure in the patients. Survivin is a member of the inhibitors of apoptosis (IAP) gene family that has been implicated in both cell viability and cell cycle regulation and described as overexpressed in most cancers. We have observed that survivin is expressed in human myeloma cell lines (HMCL) from moderate level in both HMCL XG-6 and MM1S to strong level in U2

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Ma, Xiao-Tong, Ya-Kun Mou, Yang-Yang Zhao, et al. "Set7 Is Highly Expressed in B-Lineage Acute Lymphoblastic Leukemia Cells and Overexpression of Set7 Exhibits Antileukemia Effect." Blood 128, no. 22 (2016): 5088. http://dx.doi.org/10.1182/blood.v128.22.5088.5088.

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Abstract Set7 is a member of protein lysine methyltransferase family that is highly conserved in vertebrates. Set7 can regulate the maintenance of chromosome structure, cell cycle and apoptosis, and plays an important role in many kinds of cancer, metabolism and inflammatory process. However, studies concerning its pathogenic role in leukemia are scarce. We analyzed the expression of Set7 in different types of leukemia and healthy human bone marrow cells or peripheral blood from the Oncomine databases (http://www.oncomine.org), and showed that Set7 was highly expressed in acute lymphoid leukem

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Kiso, Tetsuo, Ken-Ichi Fujita, Xu Ping, Toshio Tanaka, and Makoto Taniguchi. "Screening for Microtubule-Disrupting Antifungal Agents by Using a Mitotic-Arrest Mutant of Aspergillus nidulans and Novel Action of Phenylalanine Derivatives Accompanying Tubulin Loss." Antimicrobial Agents and Chemotherapy 48, no. 5 (2004): 1739–48. http://dx.doi.org/10.1128/aac.48.5.1739-1748.2004.

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ABSTRACT The microtubule, which is one of the major targets of anthelmintics, anticancer drugs, and fungicides, is composed mainly of α- and β-tubulins. We focused on a unique characteristic of an Aspergillus nidulans benA33 mutant to screen for microtubule-disrupting antifungal agents. This mutant, which has a β-tubulin with a mutation of a single amino acid, undergoes mitotic arrest due to the formation of hyperstable microtubules at 37°C. The heat sensitivity of the mutant is remedied by some antimicrotubule agents. We found that an agar plate assay with the mutant was able to distinguish t

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Lovi, N. K., D. Koffie, E. K. Antiri, et al. "Aggressive Plasma Cell Myeloma as an Underlying Cause of Paraparesis In an Unusually Young Male Patient." Postgraduate Medical Journal of Ghana 7, no. 2 (2022): 115–18. http://dx.doi.org/10.60014/pmjg.v7i2.177.

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Plasma Cell Myeloma, also called multiple Myeloma, is a haematological malignancy characterised by the proliferation of malignant plasma cells with an associated monoclonal paraproteinemia. The disease is described to have a median age of diagnosis in the 7thdecade of life and rare below the 4th decade. We report a case in which the patient was first diagnosed as having Multiple Myeloma at the age of 29 years. The patient had been having symptoms for at least 5 months prior to the diagnosis being arrived at. His earliest symptoms were non-specific: malaise, low grade fever, easy fatigability.

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Seideman, Jonathan H., and David A. Scheinberg. "Multi-Drug Resistance Phenotype in Myeloid Leukemia Cells Confers Radiation Resistance Via DNA Damage Sensor Uncoupling." Blood 114, no. 22 (2009): 4243. http://dx.doi.org/10.1182/blood.v114.22.4243.4243.

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Abstract Abstract 4243 We have found that a stable multi-drug resistant (MDR) variant of the myeloid leukemia line, HL60, called RV+, which was selected for drug resistance in the presence of vincristine, is clonogenically cross-resistant to gamma radiation (RV+ Do= 0.81 Gy, HL60 Do = 0.49 Gy). At equal doses, these two different cell lines incurred equivalent DNA double strand breaks (DSBs) upon irradiation as measured by pulse-field electrophoresis, and showed nearly identical bulk DSB repair capacity and efficiency, suggesting that the resistence phenotype is not due to a reduction in DSBs.

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Guzman, Monica L., Wen Xie, Jeanne P. De Leon, Francis Burrows, Eric J. Feldman, and Gail J. Roboz. "Leukemia Stem/Progenitor Cells From AML Patients Treated With The Multi-Kinase Inhibitor TG02 Demonstrate Increased Proliferation and Are Sensitized To Chemotherapeutic Agents." Blood 122, no. 21 (2013): 3892. http://dx.doi.org/10.1182/blood.v122.21.3892.3892.

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Abstract TG02 is a multi-kinase inhibitor that targets cyclin-dependent kinases (CDKs), ERK5, JAK2, and Flt3. In vitro studies of TG02 have shown robust induction of apoptosis in both acute myeloid leukemia (AML) cell lines and primary cells (Goh et al, 2011). Leukemia stem cells (LSCs) comprise a largely quiescent, highly chemotherapy-resistant cell population and are believed to initiate and maintain AML, as well as contribute to its poor prognosis. Thus, we sought to investigate the impact of TG02 on LSCs collected from patients with relapsed/refractory AML enrolled in a phase I dose escala

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Geng, Huimin, Jae-Woong Lee, Zhengshan Chen, et al. "IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia." Blood 124, no. 21 (2014): 788. http://dx.doi.org/10.1182/blood.v124.21.788.788.

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Abstract Background and hypothesis: CD25 (IL2RA, interleukin 2 receptor α chain) is a transmembrane protein with a 13aa cytoplasmic tail. CD25 cooperates with β- and γ-chains in binding IL-2, but does not contribute to cytokine signaling. During normal B cell development, CD25 is specifically upregulated on the surface of IL7-dependent pre-B cells and is also expressed on the surface of a subset of human pre-B ALL cases. CD25-expressing ALL is typically associated with poor clinical outcome. For these reasons, we studied the functional significance of CD25 expression on human pre-B ALL cells.

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Lee, Jae-Woong, Zhengshan Chen, Huimin Geng, et al. "CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia." Blood 126, no. 23 (2015): 1434. http://dx.doi.org/10.1182/blood.v126.23.1434.1434.

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Abstract Background and hypothesis: CD25 (IL2RA) represents the α chain of the interleukin 2 receptor on T cells and plays an important role in the maintenance of regulatory T (Treg) cells, hence preventing T cell autoimmunity. In a comprehensive gene expression analysis, we found that CD25 is specifically upregulated by pre-B cell receptor (pre-BCR) signaling during early B cell development and oncogenic tyrosine kinase that mimic pre-BCR signaling (e.g. in Ph+ ALL and Ph-like ALL). In adults with Ph+ ALL (ECOG; MDACC) and children with Ph-like ALL (P9906) patients with CD25 expression at the

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Maier, Armin, Monika Engelhardt, Heinz-Herbert Fiebig, and Julia Schüler. "Profiling of 24 Standard of Care Drugs in a Panel of 20 Human Hematological Cell Lines Using Xenograft-Derived Three-Dimensional (3D) Cultures Ex Vivo and In Vivo." Blood 118, no. 21 (2011): 4995. http://dx.doi.org/10.1182/blood.v118.21.4995.4995.

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Abstract Abstract 4995 Introduction: Leukemia and lymphoma account for a notable proportion of cancers worldwide. The heterogeneity and biological characteristics of hematological malignancies induce unique therapeutic challenges. It is well known that pluripotent as compared to differentiated cells possess the potential for anchorage independent growth in semisolid medium. This can be monitored via clonogenic or colony formation assays, in which cells grow in vitro in a three-dimensional (3D) manner without adherence to plastic culture material support. These assays can be utilized to evaluat

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Zukhrufan, M. Huki, and Eifel Faheri. "Diffuse large B-cell lymphoma in a patient with chronic myelogenous leukemia on accelerated phase with bilateral pleural effusion: a case report." International Journal of Research in Medical Sciences 8, no. 2 (2020): 743. http://dx.doi.org/10.18203/2320-6012.ijrms20200266.

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Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells. The pathogenesis of CML is known to be related to mutations in the form of Philadelphia chromosomes. The incidence of CML constitutes 20% of all cases of leukemia in adults. The current gold standard for CML therapy is using tyrosine kinase inhibitors (TKI), Imatinib. Non-Hodgkin Lymphoma (NHL) is a malignancy that develops from lymph nodes. In NHL the formation of malignant cells is in the form of lymphocytes that are at one of the differentiation levels of either T lymphocytes or B lymphocytes. Dif

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Yongsheng, Ruan, Enzi Jiang, Hye Na Kim та ін. "Targeting of Integrin α4/VCAM-1 with AVA4746 Modulates the Redox-Status and Metabolism in ALL and Angiogenesis". Blood 134, Supplement_1 (2019): 3881. http://dx.doi.org/10.1182/blood-2019-132101.

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Background. Treatment of resistant or relapsed acute lymphoblastic leukemia (ALL) remains a challenge. Adhesion of ALL cells via integrin α4/VCAM-1 pathway to bone marrow stromal cells promotes cell adhesion-mediated drug resistance (CAM-DR). Previously, we have shown that AVA4746, a non-peptidic small molecule integrin α4 antagonist, functionally de-adheres patient-derived B-ALL cells from VCAM-1. Furthermore, we demonstrated that antagonizing VCAM-1 by AVA4746 in combination with traditional chemotherapy prolongs survival of B-ALL xenograft NSG mice derived from a relapsed B-ALL patient. The

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