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Academic literature on the topic 'Forms of preparation'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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Journal articles on the topic "Forms of preparation"

1

Picotti, Lorenzo. "Expanding forms of preparation and participation." Revue internationale de droit pénal 78, no. 3 (2007): 405. http://dx.doi.org/10.3917/ridp.783.0405.

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Chang, Wun-Shaing W., and Paul L. Harper. "Commercial Antithrombin Concentrate Contains Inactive L-forms of Antithrombin." Thrombosis and Haemostasis 77, no. 02 (1997): 323–28. http://dx.doi.org/10.1055/s-0038-1655962.

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SummaryThe preparation of antithrombin concentrate for clinical use requires a viral inactivation step. In most commercial preparations this is achieved by heat pasteurisation. This process would be expected to alter the conformation of antithrombin from the active native species to an inactive latent (L-form) state (1, 2). To determine if this occurs during commercial preparation and to identify the proportion of the product in the inactive state, we examined the various antithrombin conformations within a therapeutic concentrate. The antithrombin concentrate was separated into five fractions by heparin-Sepharose chromatography. The fraction with the highest heparin affinity retained full activity, whereas the four fractions with reduced heparin affinity (~40% of the total antithrombin) had lost their inhibitory function. These inactive antithrombins were intact, monomeric, thermostable and resistant to unfolding in 8 M urea. Moreover, the protein patterns on isoelectric focusing and non-denaturing-PAGE showed that there were at least two different L-forms with isoelectric points separate from the native active species. Our findings demonstrate that approximately 40% of the antithrombin preparation examined exists as inactive l-forms. The clinical significance of administering this altered material is uncertain.

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KHALIFA, Ahmed. "The expanding forms of preparation and participation." Revue internationale de droit pénal 80, no. 3 (2009): 443. http://dx.doi.org/10.3917/ridp.803.0443.

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Dahanayake, Jeevani Maheshika, Pathirage Kamal Perera, Priyadarshani Galappatty, Hettiarachchige Dona Sachindra Melshandi Perera, and Liyanage Dona Ashanthi Menuka Arawwawala. "Comparative Phytochemical Analysis and Antioxidant Activities of Tamalakyadi Decoction with Its Modified Dosage Forms." Evidence-Based Complementary and Alternative Medicine 2019 (May 2, 2019): 1–9. http://dx.doi.org/10.1155/2019/6037137.

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Background and Objective. Tamalakyadi decoction (TD) is a classical formulation mentioned in authentic traditional medicine text Sarasankshepaya under nasal diseases and used as a remedy for allergic rhinitis. It consists of 12 plant ingredients. Decoction preparations are widely used in Sri Lankan traditional system and considered effective and safe for treating many disorders. However, decoctions have to be used only in fresh state due to shorter shelf life and loss of stability. This decoction preparation method leads to decreasing the patient compliance and is also time consuming. Hence, the objective of the present study was to convert TD to consumer friendly novel dosage form, namely, freeze dried, spray dried, and traditional ganasara forms. Methodology. Therefore, we compared the phytochemical constituents and antioxidant activities of TD with its modified dosage forms. The chemical comparison of four dosage forms comprises phytochemical screening, TLC and HPTLC fingerprint profiles and the antioxidant activities by DPPH free radical scavenging activity, Ferric reducing antioxidant power (FRAP), total polyphenol content (TPC), and total flavonoid content (TFC). Results. Phytochemical screening revealed the presence of alkaloids, saponins, tannins, steroids, flavonoids, phenols, and terpenoids in all dosage forms. However, the saponins, alkaloids, flavonoids, terpenoids, and steroids were more prominent in TD and freeze dried preparation than the other two preparations. HPTLC fingerprint pattern of freeze dried dosage was more similar with HPTLC fingerprint pattern of TD in terms of number of peaks and their intensity compared to that of spray dried and ganasara dosage forms. Antioxidant activities such as DPPH, FRAP, TPC, and TFC were higher in decoction and freeze dried preparation than in spray dried and ganasara preparation. Conclusion. Freeze dried TD is the most suitable ready to use preparation having similar chemical properties and antioxidant activities to TD.

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Olsen, R. L., T. K. Steigen, T. Holm, and C. Little. "Molecular forms of myeloperoxidase in human plasma." Biochemical Journal 237, no. 2 (July 15, 1986): 559–65. http://dx.doi.org/10.1042/bj2370559.

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A radioimmunoassay for myeloperoxidase was established with the use of affinity-purified anti-(human myeloperoxidase) immunoglobulins. By the use of ion-exchange followed by immunoaffinity chromatography a preparation of immunoreactive, catalytically active myeloperoxidase was obtained from fresh human plasma. In non-denaturing gel electrophoresis, the plasma preparation showed about four catalytically active components of mobility very similar to that of the granulocyte enzyme. SDS/polyacrylamide-gel electrophoresis combined with protein blotting showed that the two polypeptides of strongest antigenicity in the plasma preparation corresponded in Mr to the large and the small subunits of the granulocyte enzyme. In addition, the plasma preparation contained a higher-Mr immunoreactive polypeptide, possibly a precursor form of the enzyme, together with another of Mr similar to that of the large subunit of eosinophil peroxidase.

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Kiseļova, Olga, Baiba Mauriņa, and Venta Šidlovska. "Analysis of Extemporaneous Prescriptions Prescribed by Dermatovenerologists in Latvia and Comparison with Standardized Compounded Preparation Monographs of Germany and USA." Medicina 56, no. 1 (January 10, 2020): 29. http://dx.doi.org/10.3390/medicina56010029.

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Background and objectives: Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology. In several countries, dermatovenerologists are one of the specialists prescribing extemporaneous medicines the most. In order to increase the quality of compounded medications and minimize risks to patient safety, several countries, for example, Germany and the United States of America (USA), created standardized compounded preparation monographs. Latvia, unlike these countries, does not have any officially approved standardized compounded preparation monographs. The purpose of this survey is to analyze the extemporaneous prescriptions prescribed by Latvian dermatovenerologists to identify the active ingredients, combinations of active ingredients, and excipients prescribed by dermatovenerologists the most often, and to find out how many active ingredients are most often compounded in different dosage forms. To understand whether the extemporaneous formulations used in Latvia for dermatological indications are evidence-based, they were compared with German and USA formulations. Materials and Methods: A database was created entering data on all the prescriptions prepared in the selected pharmacies in 2017 to summarize information on extemporaneous prescriptions. The prescriptions prescribed by Latvian dermatovenerologists were selected and compared with German and USA formulations. Results: Data from 17 Latvian pharmacies were collected, and 2521 extemporaneous formulations were analyzed. In preparation of semi-solid dosage forms, 25 bulk drug substances and 37 industrially manufactured preparations were used; in preparation of suspensions, 25 bulk drug substances and 10 industrially manufactured preparations were used; in preparation of topical solutions, 23 bulk drug substances and two industrially manufactured preparations were used; in preparation of topical powders, nine bulk drug substances were used; in preparation of oral solutions, five bulk drug substances were used. Conclusions: The analyzed prescriptions contained active ingredients used in Germany and the USA, as well as active ingredients, the use of which is limited in Germany and the USA. In Latvia, topical dosage forms containing two or more active ingredients are widely prescribed.

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Bouwman, Y. "GRP-161 Risk Assessment Forms For Pharmacy Preparation." European Journal of Hospital Pharmacy 20, Suppl 1 (March 2013): A58.1—A58. http://dx.doi.org/10.1136/ejhpharm-2013-000276.161.

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Kumar, Lokesh, Aeshna Amin, and ArvindK Bansal. "Preparation and Characterization of Salt Forms of Enalapril." Pharmaceutical Development and Technology 13, no. 5 (January 2008): 345–57. http://dx.doi.org/10.1080/10837450802244686.

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Salem, M. Sheikh, G. K. Pillai, L. Nabulsi, H. N. Al-Kaysi, T. A. Arafat, A. Abu Malooh, M. Saleh, and A. A. Badwan. "Preparation, characterisation and transformation of terfenadine polymorphic forms." International Journal of Pharmaceutics 141, no. 1-2 (September 1996): 257–59. http://dx.doi.org/10.1016/0378-5173(96)04626-1.

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Singh, Prashant Kumar, Nirmal Bhusal, and Binod Kumar Singh. "SIGNIFICANCE OF CLASSICAL AYURVEDA DOSE FORMS IN CURRENT PRACTICE – A REVIEW." Healer 2, no. 02 (July 31, 2021): 93–97. http://dx.doi.org/10.51649/healer.74.

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Rasashastra & Bhaishajya kalpana is the science of Drugs including identification, procurement, processing, preparation and application. Rasashastra deals with Rasaushadis (herbo-mineral preparations) while Bhaishajya kalpana deals with Kasta-Aushadhi (herbal preparations). All classical text, in particular Charaka samhita, Sushruta samhita, Sharangadhara samhita, Kashyapa samhita etc. have described details of science of posology. The review is done to find the relevance of classical dose in current clinical practice. In this review concept of AushadhaMatra was studied in detail and conclusion was drawn. To get maximum benefit of Ausadha one should have to consider Aturabala and Rogabala before deciding the AushadhaMatra. The scientific approach, type of drug, time and route of administration, different forms and dosage and regimes in Ayurveda are highly significant in current scenario.

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Dissertations / Theses on the topic "Forms of preparation"

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Boutell, Suzanne Louise. "Factors influencing the preparation of spherical granules by extrusion/spheronisation." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481206.

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Miller, Julie J. "Preparation for Remarriage: Utilization of Different Forms and Their Rated Helpfulness." DigitalCommons@USU, 2007. https://digitalcommons.usu.edu/etd/2591.

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Remarriage has gained special attention in the past couple of decades from clinicians, researchers, and educators because of the unique issues faced by individuals entering such a relationship. Recognition of these issues increased marriage practitioners' hope that a shift in the social climate had led individuals to prepare for remarriage through various means. This study sought to, one, gain a current perspective on remarriage preparation; two, learn how individuals rate the helpfulness of preparation; and three, note any differences in remarital quality (remarital satisfaction and adjustment) and perceptions of preparedness between individuals who did or did not participate in preparation. Data were analyzed from the Utah Newlywed Study. Results showed that most individuals prepared by talking to others or read ing written information, and most individuals who participated in some form of preparation found it helpful. Despite a high number of participants who reported remarriage preparation as helpful, nonparticipants were more plentiful than participants. The majority of those who did not participate reported preparation as unnecessary. Remari tal quality varied based on the preparation form considered. Based on the resu lts, it was suggested that marriage practitioners should do more to increase individuals' views that preparation is valuable, as those who participated generally found it to be helpful.

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Race, Angela J. "New forms of nurse teacher preparation 1989-1992 : development and evaluation." Thesis, University of Surrey, 1995. http://epubs.surrey.ac.uk/843143/.

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Radical reform of the arrangements for pre-registration nurse education and the recommendation that nurse teaching become a graduate profession prompted a reappraisal of the arrangements for nurse teacher preparation. This thesis reports an evaluation of a new form of preparation for nurse teaching. The new courses were intended to combine advanced study of nursing with educational theory and practice, and led to an honours degree and a teaching qualification recordable on the professional register. The study used the fourth generation evaluation model as a theoretical framework. During the early stages of the work, a secondary research purpose emerged - to evaluate the fourth generation model. This model has a qualitative focus, and emphasises the participation of all stakeholders with an interest in the outcomes of the evaluation. Participants in the enquiry were student nurses, nurse teachers, and to a lesser extent, teacher course leaders. The multi-method research design included document analysis; group interviews; postal questionnaires; non-participant observation; individual interviews. Rich qualitative data obtained from a small number of participants illuminated the quantitative data gathered from a national postal survey of all the nurse teachers (n=109) who graduated in 1992 from the seven courses studied. A joint construction of an effective nurse teacher was developed from the data. It was concluded that the nurse teachers were broadly satisfied with the quality of the preparation courses. However, of the nine role elements included in the preparation courses, in only three elements did more than half the nurse teachers feel equipped for their new roles. In six role elements more than half the nurse teachers did not feel equipped. Credibility of the enquiry findings, the conclusions and recommendations were enhanced by a quality audit of the enquiry process and a critical review of the theoretical model. The fourth generation evaluation model was shown to be effective in revealing deficits in nurse teacher preparation which had become apparent when the respondents embarked on their new roles. Recommendations based on the findings encompassed both action and further research and were directed towards i) improving current courses for nurse teacher preparation ii) re-examining a crucial role element - the clinical role iii) re-examining the focus, location and organisation of nurse teacher preparation.iv) further creative application of the fourth generation model.

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D’Agostino, Simone <1981&gt. "Preparation of new crystal forms via photochemical, mechanochemical and sol-gel methods." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4650/.

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This work of thesis involves various aspects of crystal engineering. Chapter 1 focuses on crystals containing crown ether complexes. Aspects such as the possibility of preparing these materials by non-solution methods, i.e. by direct reaction of the solid components, thermal behavior and also isomorphism and interconversion between hydrates are taken into account. In chapter 2 a study is presented aimed to understanding the relationship between hydrogen bonding capability and shape of the building blocks chosen to construct crystals. The focus is on the control exerted by shape on the organization of sandwich cations such as cobalticinium, decamethylcobalticinium and bisbenzenchromium(I) and on the aggregation of monoanions all containing carboxylic and carboxylate groups, into 0-D, 1-D, 2-D and 3-D networks. Reactions conducted in multi-component molecular assemblies or co-crystals have been recognized as a way to control reactivity in the solid state. The [2+2] photodimerization of olefins is a successful demonstration of how templated solid state synthesis can efficiently synthesize unique materials with remarkable stereoselectivity and under environment-friendly conditions. A demonstration of this synthetic strategy is given in chapter 3. The combination of various types of intermolecular linkages, leading to formation of high order aggregation and crystalline materials or to a random aggregation resulting in an amorphous precipitate, may not go to completeness. In such rare cases an aggregation process intermediate between crystalline and amorphous materials is observed, resulting in the formation of a gel, i.e. a viscoelastic solid-like or liquid-like material. In chapter 4 design of new Low Molecular Weight Gelators is presented. Aspects such as the relationships between molecular structure, crystal packing and gelation properties and the application of this kind of gels as a medium for crystal growth of organic molecules, such as APIs, are also discussed.

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Sujja-Areevath, Jomjai. "Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen." Thesis, Robert Gordon University, 1997. http://hdl.handle.net/10059/2347.

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Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm in diameter) were produced by the wet granulation method. The release profiles from several encapsulated minimatrices in phosphate buffer solution (pH 7.0) showed that xanthan, karaya and locust bean gums could sustain the release of diclofenac sodium while the carrageenan gum did not produce a satisfactory sustaining effect. The rank order of decreasing swelling rate in both axial and radial dimensions was xanthan > karaya > locust bean gum and each of these gums showed almost Fickian swelling behaviour. The solvent penetration rates were consistent with the swelling rates. However, the order of decreasing drug release and erosion rates was locust bean> xanthan > karaya gum. For each of these gums, the release behaviour was anomalous indicating that both Fickian drug diffusion and polymer relaxation were involved in the release process. The dominant mechanism depended on the nature and content of the gum, as well as the stage in the dissolution period. The study involving xanthan gum showed that the diclofenac sodium release rate declined linearly with a progressive increase in the gumcontent, without changing the release behaviour. However, for high drug: xanthan gum ratio (2:1), the release kinetics changed to Super Case II. Solubility differences between the excipients did not affect the release rate, but increasing proportions of each excipient produced a faster release rate with the release mechanism changing from anomalous to Case II and then to Super Case II transport. Mini-matrices containing HPMC produced faster drug release than those containing the three natural gums. There was no synergistic effect between xanthan and locust bean gums on the release of diclofenac sodium from mini-matrices. Variation in the stirring speed (used in the dissolution apparatus) and matrix volume had little effect on drug release, whereas the pH of the dissolution medium greatly affected the release of diclofenac sodium. Following on from the studies involving diclofenac sodium, xanthan and karaya gums were used to produce mini-matrices of S(+) ibuprofen. Excipients with good compressibility characteristics such as lactose, Encompress® and Avicel PH101® were needed in the formulations. At pH 7, higher drug release rates were obtained with karaya gum (Super Case II mechanism) compared with xanthan gum (anomalous behaviour). Solubility differences between the excipients slightly affected the release rate. Compression forces (11 - 26 kN) slightly affected the crushing strength. The minimatrices were relatively stable to variation in temperature (5 - 37°C) and relative humidity (10 - 75%) over a 2 month time period. These studies have shown that near zero-order release of diclofenac sodium and S(+) ibuprofen can be achieved using encapsulated mini-matrices formulations. The release mechanisms and release rates can be adjusted by variation of the type and content of gums and/or excipients.

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Nannapaneni, Vijaysri. "Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/274.

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Spray drying is widely used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites were subjected to Fourier Transform Infrared Sprectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (XRPD). The data showed that the crystalline model drugs were converted to amorphous form upon spray drying, whereas the physical mixtures did not change their crystallinity. The effect of the amorphous forms produced by Spray drying on apparent solubility and intrinsic dissolution rate was determined. All the spray dried composites exhibited higher apparent solubility and intrinsic dissolution rate when compared to the pure drugs and their physical mixtures. The stability of the spray dried composites upon storage was also determined. The amorphous nature of the compounds in the spray dried composites were retained during 3 months storage as shown by FTIR, DSC and XRPD characterization and their apparent solubility and intrinsic dissolution rates also did not change.

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7

Le, Roux Marga. "Preparation and evaluation of doxycycline hydrochloride and bromhexine hydrochloride dosage forms for pigeons / Marga le Roux." Thesis, North-West University, 2004. http://hdl.handle.net/10394/580.

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Objective: To prepare and evaluate three different dosage forms, containing doxycycline hydrochloride (HCI) and bromhexine hydrochloride (HCI) respectively and in combination, for the treatment of respiratory diseases in pigeons. Background: Birds have held a place in man's affection since the ancient Egyptians and Romans kept birds. Europeans have successfully bred birds, especially smaller birds and pigeons, for centuries. Only in recent years, however, have science and medicine been applied to aviculture and pet care. Pigeon racing is one of the sports not well known to the general public. These sportsmen invest a great deal to ensure that their pigeons are disease free. During racing they are exposed to infectious agents in the racing baskets and bring these pathogens back to the racing flock. If you ask any experienced flier what health problem he fears most for his pigeons during the racing season, he will probably say respiratory infection. Respiratory diseases are very common in pigeons. They are the major cause of poor performance and pigeon loss during the racing season. Doxycyline HCI, a broad-spectrum antibiotic, is the world-wide veterinary therapeutic agent of choice for the treatment of Chlamydia, a principle cause of respiratory infection. Doxycyline HCI has several advantages: greater activity, providing effective blood levels for up to 20 hours after a single dose compared to 4 hours for older tetracyclines; causes less disruption to the normal bowel bacteria; has less detrimental effect on the immune system; and is less affected by calcium and other minerals. Bromhexine HCI is an expectorant drug, promoting bronchial secretion and having mucolytic properties. It is commonly used in combination with antibiotics such as doxycycline HCI for the treatment of respiratory infections in the pigeon loft. Because avian medicine has not been commercialised as much as those for human use, it has left fanciers experimenting with dosage forms and strengths resulting in severe consequences. There is a great need for sophisticated medication developed specifically for the pigeon market. Methods: This study investigated the formulation of a direct compressed tablet and a water-soluble powder containing doxycycline HCI and bromhexine HCI respectively and in combination. The formulation and evaluation of the stability of an ophthalmic solution, containing doxycycline HCI was also investigated. Initial test were done on all three formulations. The tablets were inspected visually and tested for uniformity of mass, hardness, friability, disintegration, assay and dissolution. The water-soluble powder was tested for its pH, constitution time, assay, moisture content and visual properties. An "in use" assay was also done on the doxycycline HCI powder. Three containers (stainless steel, glass and plastic) were used and the powder was dissolved in tap water (5 mglml). Samples were taken from every container after 0, 6, 12 and 24 hours and analysed. The results obtained were compared to the same powder but with no citric acid in the formulation. The same containers and time intervals were used for the comparing powder. The ophthalmic solution's appearance, pH, density, viscosity, assay, particulate matter and preservative efficacy were tested. The formulations were stored at three different temperatures and humidities for three months. The above mentioned tests were repeated after every month. An HPLC method for the simultaneous determination of doxycycline HCI and bromhexine HCI was developed and validated. Results and discussion: Based on the different test results generated over the twelve weeks of stability evaluation of the products that were developed in this study, doxycycline HCI and bromhexine HCI, respectively and in combination, seemed to have been relatively stable. The final tablets, water-soluble powders and ophthalmic solution formulations remained stable. The "in use" assay of the powder containing citric acid showed no discoloration, precipitation or breakdown when dissolved in water for a period of 24 hours. The powder lacking the citric acid showed discoloration after only 3 hours. This powder showed significant breakdown as well. The containers used for the storage of the tablets and the powders didn't seal tight enough. The moisture uptake was very high resulting in poor disintegration and dissolution times. Therefore the powder and the tablets should be stored in tightly sealed containers with enough silica as drying agent. The containers used for the tablets, powders and ophthalmic solution respectively, seemed not to influence the stability of the formulations negatively. The newly developed and validated HPLC method was used to analyse the stability samples and it proved to be reliable and easy to execute. Conclusion: Accelerated stability tests indicated that the formulations remained stable and that no significant breakdown occurred. Complete stability trial studies should however be conducted to claim their stability. The newly developed HPLC method was used over the twelve-week period to analyse accelerated stability samples, and it proved to be reliable and easy to carry out.
Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2005.

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Dube, Admire. "The design, preparation and evaluation of Artemisia Afra and placebos in tea bag dosage form suitable for use in clinical trials." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2915_1188480959.

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Artemisia Afra, a popular South African traditional herbal medicine is commonly administered as a tea infusion of the leaves. However, clinical trials proving it safety and efficacy are lacking mainly due to the absence of good quality dosage forms and credible placebos for the plant. The objectives of this study were to prepare a standardized preparation of the plant leaves and freeze-dried aqueous extract powder of the leaves, in a tea bag dosage form and to design and prepare credible placebos for these plant materials.

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Dubald, Marion. "Development of antibiotic-based ophthalmic preparations for the treatment of local infections." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1201.

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Depuis ces dernières décennies, l'administration ophtalmique est devenue une voie privilégiée des molécules en vue d'une action locale. La sécurité, l'efficacité et l'acceptabilité de ces médicaments imposent une formulation stérile et facilement applicable pour l'amélioration de l'observance du patient. L'objectif de ce travail a été de développer une forme ophtalmique topique efficace, facilement applicable et contenant un principe actif (PA) d'intérêt. Les études d'encapsulation du PA dans des particules de polymères en vue de sa protection mettent en évidence la difficulté de formuler des vecteurs avec un PA hydrosoluble. Son instabilité en solution aqueuse a été démontrée lors des études de stabilité et a orienté le choix galénique vers des préparations semi-solides. L'absence, ou la faible quantité d'eau présente, améliore la stabilité du PA. L'association des cyclodextrines dans la formulation montre une nette stabilisation du PA dans les préparations semi-solides. Les études de caractérisation de ces formes mettent en évidence la stabilité du PA dans une pommade hydrophobe et dans une émulsion en présence de cyclodextrine. De plus, les essais de microbiologie démontrent l'intérêt de l'utilisation d'une émulsion dans l'efficacité de la forme pharmaceutique contre Staphylococcus aureus. Les formes ophtalmiques mise au point présentent un intérêt majeur dans le traitement d'infections oculaires localisées en remplacement des thérapeutiques actuellement sur le marché
Over the last few decades, ophthalmic administration has become a preferred route for molecules for local action. The safety, efficacy and acceptability of these drugs require a sterile and easily applicable formulation for improved patient compliance. The objective of this work was to develop an effective, easily applicable topical ophthalmic form containing a drug of interest. Studies of the encapsulation of API in polymer particles for protection show the difficulty of formulating vectors with a water-soluble API. The instability of the drug in aqueous solution has been demonstrated in stability studies and guided galenic choice to semi-solid preparations. The absence, or small amount of water, improves the stability of the API. The association of cyclodextrins in the formulation shows a marked stabilization of the drug in semi-solid preparations. Characterization studies of these forms demonstrate the stability of the drug in a hydrophobic ointment and in an emulsion in the presence of cyclodextrin. Moreover, microbiological tests demonstrate the advantage of using an emulsion in the efficacy of the pharmaceutical form against Staphylococcus aureus. The ophthalmic forms developed are major interest in the treatment of localized eye infections in place of the therapeutics currently on the market

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Mérian-Brosse, Laurence. "Préparations pharmaceutiques hospitalières : intérêt de l'élaboration d'un formulaire, cas de trois préparations liquides destinées à la voie orale." Paris 5, 1991. http://www.theses.fr/1991PA05P126.

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Books on the topic "Forms of preparation"

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Nickerson, Beverly, ed. Sample Preparation of Pharmaceutical Dosage Forms. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2.

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Osborne, Cynthia Monteiro. Paralegal preparation of pleadings. 3rd ed. Santa Ana, CA: James Publishing Group, 1991.

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Commercial real estate leases: Preparation, negotiation, and forms. 5th ed. Austin [Tex.]: Wolters Kluwer Law & Business, 2011.

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Turco, Salvatore J. Sterile dosage forms: Their preparation and clinical application. 3rd ed. Philadelphia: Lea & Febiger, 1987.

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Commercial real estate leases: Preparation, negotiation, and forms. 3rd ed. Gaithersburg [Md.]: Aspen Law & Business, 2000.

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Turco, Salvatore J. Sterile dosage forms: Their preparation and clinical application. 4th ed. Philadelphia: Lea & Febiger, 1994.

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Simon, Veronica E. Legal documents: Step by step preparation. Flint, MI (5014 N. Saginaw St., Flint 48505): Tejia Pub. Co., 1988.

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Nickerson, Beverly. Sample Preparation of Pharmaceutical Dosage Forms: Challenges and Strategies for Sample Preparation and Extraction. Boston, MA: American Association of Pharmaceutical Scientists, 2011.

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Commercial real estate leases: Preparation and negotiation. 2nd ed. New York: Wiley Law Publications, 1990.

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Gense, Carol Dehler. Medical & Dental Associates, P.C. insurance forms preparation: ECT/PPO/03100/BP. 2nd ed. Cincinnati, OH: South Western Pub. Co., 1990.

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Book chapters on the topic "Forms of preparation"

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Liu, Yang, George L. Reid, and Zhongli Zhang. "No Sample Preparation." In Sample Preparation of Pharmaceutical Dosage Forms, 355–85. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_15.

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Bishop, Edmund J., Dawen Kou, Gerald Manius, and Hitesh P. Chokshi. "Sample Preparation Method Validation." In Sample Preparation of Pharmaceutical Dosage Forms, 233–51. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_10.

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Xue, Gang, and K. Rick Lung. "Automation and Sample Preparation." In Sample Preparation of Pharmaceutical Dosage Forms, 285–307. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_12.

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Ferguson, Paul, and Mark Harding. "Green Chemistry Considerations for Sample Preparation." In Sample Preparation of Pharmaceutical Dosage Forms, 333–54. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_14.

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Nickerson, Beverly, and Garry Scrivens. "Sample Preparation for Solid Oral Dosage Forms." In Sample Preparation of Pharmaceutical Dosage Forms, 145–78. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_7.

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Bu, Xin, Sachin Chandran, John Spirig, and Qinggang Wang. "Sample Preparation for Select Nonsolid Dosage Forms." In Sample Preparation of Pharmaceutical Dosage Forms, 179–210. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_8.

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Nickerson, Beverly. "Properties That Impact Sample Preparation and Extraction of Pharmaceutical Dosage Forms." In Sample Preparation of Pharmaceutical Dosage Forms, 3–19. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_1.

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Pellett, Jackson D., Beverly Nickerson, and Ivelisse Colón. "Application of Quality by Design Principles for Sample Preparation." In Sample Preparation of Pharmaceutical Dosage Forms, 253–81. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_11.

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Nickerson, Beverly, Ivelisse Colón, Eddie Ebrahimi, Garry Scrivens, and Lin Zhang. "A Systematic Approach for Investigating Aberrant Potency Values." In Sample Preparation of Pharmaceutical Dosage Forms, 309–32. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_13.

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Kou, Dawen, Hua Ma, Edmund J. Bishop, Shangdong Zhan, and Hitesh P. Chokshi. "Sampling Considerations." In Sample Preparation of Pharmaceutical Dosage Forms, 21–39. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_2.

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Conference papers on the topic "Forms of preparation"

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Podchinenov, Alexey V. "On one of the Forms of Scientific Journal Development." In World-Class Scientific Publication – 2017: Best Practices in Preparation and Promotion of Publications. ASEP; NP “NEICON”; Ural University Press, 2017. http://dx.doi.org/10.24069/2017.978-5-7996-2227-5.18.

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Steven, I., L. Wagner, W. E. van Nostrand, and D. D. Cunningham. "PREPARATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO PROTEASE NEXIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644447.

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Protease nexin I (PN-1) is a cell-secreted protease inhibitor which modulates the activity of certain serine proteases in the extracellular environment. To probe PN-1 functions, we prepared a panel of monoclonal antibodies (mAbs) against it and studied their effects on a variety of PN-1 activities. Three highly potent inhibitors of PN-1 activity have been characterized. MAbs pl-6 and pl-9 stoichiometri-cally block PN-l-mediated anti-thrombin and anti-urokinase activity. These mAbs block PN-l-mediated anti-trypsin activity less effectively. MAb pl-18 stoichiometrically blocks all PN-1 antiprotease activities tested including anti-trypsin activity and therefore appears to bind at the reactive center of PN-1. Heparin, which greatly accelerates PN-1 anti-thrombin activity, does not compete with the binding of these blocking mAbs. None of these blocking mAbs could bind to thrombin-PN-1 complexes. A mAb (pl-1) which did not block PN-1 activity was capable of binding to these complexes. MAbs pl-9 and pl-18 were used to immunopurify two forms of PN-1 which have different affinities for heparin-Sepharose. These have been referred to as the low heparin affinity and high heparin affinity forms of PN-1 (Scott et al., J. Biol. Chem. 260,7029-7034 [1985]). MAb pl-18 binds only to the high heparin affinity form while mAb pl-9 binds to both forms. Preliminary characterization of this low heparin affinity form reveals no major differences between it and the well characterized high heparin affinity form.

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Baranov, V., and R. Gnutikov. "Tools of extraction and procedures of preparation of linguistic data for statistic analysis in the historical corpus «Manuscript»." In Historical research in the context of data science: Information resources, analytical methods and digital technologies. LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1797.978-5-317-06529-4/113-119.

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Considered is the task of automatic reduction of the text forms with variable graphics and orthography of the corpus “Manuscript” (manuscripts.ru), comprising exact transcriptions of Slavonic medieval manuscripts, to one and only one lemma, which is necessary for correct statistic analysis of the corpus linguistic data. Several ways and procedures of comparison of normalized forms, which are available in the corpus electronic dictionary, with the text forms are proposed.

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Baranov, V., and R. Gnutikov. "Tools of extraction and procedures of preparation of linguistic data for statistic analysis in the historical corpus «Manuscript»." In Historical research in the context of data science: Information resources, analytical methods and digital technologies. LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1797.978-5-317-06529-4/113-119.

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Considered is the task of automatic reduction of the text forms with variable graphics and orthography of the corpus “Manuscript” (manuscripts.ru), comprising exact transcriptions of Slavonic medieval manuscripts, to one and only one lemma, which is necessary for correct statistic analysis of the corpus linguistic data. Several ways and procedures of comparison of normalized forms, which are available in the corpus electronic dictionary, with the text forms are proposed.

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Маевская, Марина, and Marina Maevskaya. "Law schools and employers cooperation as a factor of graduating students` preparation of high quality and their job connection." In St. Petersburg international Legal forum RD forum video — Rostov-na-Donu. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_5a3a6fa961c8c9.43911596.

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The article is devoted to evaluation of priority forms of cooperation between institutes and employers, and troubled points, which impede their cooperation. Taking into account identified shortcomings (disadvantages), the most effective forms of cooperation are performed. Moved a motion of supplement to Federal act «Of Education in the Russian Federation» relating to practical studies (job training) of law school students. The model of dual education is subjected to evaluation, this model is considered to be one of the advanced forms of effective cooperation of law schools and employers. Reasoned the offer of practicability and timely adoption the model of dual education for jurist students.

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Nchinech, N., H. Attjioui, FZ Aglili, Y. Kriouile, A. Alaoui Mdaghri, Y. Cherrah, and S. Serragui. "5PSQ-080 Assessment of dose preparation practices from liquid oral forms by mothers of children hospitalised in our paediatric department." In 25th EAHP Congress, 25th–27th March 2020, Gothenburg, Sweden. British Medical Journal Publishing Group, 2020. http://dx.doi.org/10.1136/ejhpharm-2020-eahpconf.397.

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"Preparing a Vienna Project Week in Web 2.0 (from Approved Forms of Preparation to E-Learning Resulting in E-Content)." In GI_Forum 2013 - Creating the GISociety. Vienna: Austrian Academy of Sciences Press, 2013. http://dx.doi.org/10.1553/giscience2013s428.

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Vinichenko, Mikhail Vasilievich, Alexander Vasilievich Melnichuk, and Sergey Anatolievich Makushkin. "Implementation of game methods in the preparation of management personnel." In Fourth International Conference on Higher Education Advances. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/head18.2018.8000.

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The search for increasing the effectiveness of training leads to the use of innovative technologies, which include gaming. The purpose of this article was to identify the extent and nature of the introduction of gaming methods in the educational process of the Russian State Social University. The paper used a comparative analysis of students and teachers assessment of management training using the gaming of the educational process. The empirical basis was the results of a sociological survey conducted using the Google Forms online service. 48 teachers and 178 students took part in the sociological survey. As a result, it was possible to establish that the introduction of gaming in the university is controversial. Despite the understanding of the usefulness of gaming by university employees, only 29% of teachers constantly use gaming methods. Students are dissatisfied with this, noting that gaming techniques are either fragmented (54%) or not used at all (37%). Students with a desire to participate in classes with gaming methods, especially in an integrated business game. Achievement of students' success at the class increases their social status. The study showed that the potential for gaming is not fully used.

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Berrettini, M., M. J. Heeb, and J. H. Griffin. "ISOLATION AND FUNCTIONAL PROPERTIES OF MONOMERIC BLOOD COAGULATION FACTOR XI." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642803.

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To evaluate the significance of the normal dimeric structure (160,000 MW) of blood coagulation Factor XI (F.XI), a monomeric form (80,000 MW) was produced by mild reduction and alkylation of native F.XI. Since initial efforts to reduce and alkylate F.XI in solution inactivated the molecule, F.XI was bound to high MW kininogen (HMWK) to stabilize the native structure. Purified F.XI was bound to HMWK-Sepharose, and the column was washed for 2 h with 40 μM dithiothreitol in 4mM acetate buffer, 2mM EDTA, 1mM benzamidine, pH 7.8, and then for 2 h with 50 μM iodoacetamide in the same buffer. Elution with 0.5 M NaCl gave a preparation containing ∼ 85% F.XI monomer and ∼ 15% dimer, as judged by nonreduced SDS-PAGE and by gel filtration of the radiolabeled preparation. The monomeric F.XI preparation had only 10% of the clotting activity of dimeric F.XI (per mole of enzymatic site) as measured in APTT clotting assays using F.XI deficient plasma. After activation with β-Factor XIIa in solution, the monomer F.XIa preparation exhibited 85% of the clotting activity of native F.XIa in unactivated PTT assays using F.XI deficient plasma. In addition, when compared to native F.XIa, monomeric F.XIa gave 65% amidolytic activity against the substrate, S-2366, and 75% activity against Factor IX in assays of the release of the activation peptide from 3H-Factor IX. Polystyrene tubes were coated with HMWK then blocked with 1% BSA to study the binding of 125I-F.XI to HWMK. When the binding of the 125I-labeled preparations of monomeric and dimeric forms of F.XI to HMWK was studied, two distinct components were identified in the association of dimeric F.XI, one with high affinity (Kd ∼ 2.5 X 10-9M) and one with less affinity (Kd ∼ 1.7 X 10-8M), while the binding of monomeric F.XI occurred with a single low affinity component (Kd ∼ 1.1 X 10-8M). These observations suggest that the dimeric structure of F.XI is required for efficient binding of the molecule to HMWK and for normal activation by the contact activation system in plasma, but that the dimeric structure of F.XIa does not play a role in the expression of the enzymatic activity against Factor IX in fluid phase.

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Joldeska, Irina, and Stevcho Mecheski. "Establishing an Annual Account for Performers of Independent Activity." In 5th International Scientific Conference 2021. University of Maribor Press, 2021. http://dx.doi.org/10.18690/978-961-286-464-4.17.

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The preparation of the Annual account is mandatory for all economic entities in the Republic of North Macedonia. Depending on the type of categorized economic entity, special forms are prepared prescribed by law, in order to summarize them in the Annual account. Performers of independent activity are economic entities that include an individual person – entrepreneur, sole proprietorship an individual person who is engaged in performing agricultural, craft activity, as well as a person who performs a service or free occupation. Accordingly, at the end of the year, it is necessary to prepare an Annual account which contains the Income and Expenses Balance, the Annual Tax Balance for determining the income tax from performing an independent activity and the Income Structure by activities. The main purpose of the paper is to reflect the legislation of a certain part of companies registered in accordance with the law in The Republic of North Macedonia for external reporting and tax purposes. Hence, as a conclusion, the practical preparation of the three forms, implemented in the Annual Account of a sole proprietorship can be seen.

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Reports on the topic "Forms of preparation"

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Staples, B. A., D. A. Knecht, and T. P. O`Holleran. Preparation of plutonium waste forms with ICPP calcined high-level waste. Office of Scientific and Technical Information (OSTI), May 1997. http://dx.doi.org/10.2172/554797.

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Baldwin, T. E., W. A. Buehring, M. J. Jusko, J. M. Keisler, R. G. Whitfield, and T. D. Wolsko. Instructions for the preparation of Resource Allocation Support System (RASS) data forms. Office of Scientific and Technical Information (OSTI), March 1994. http://dx.doi.org/10.2172/10151527.

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Patel, Deep, Kenneth Graf, and David Fuller. Hip Surgical Preparation Educational Video. Rowan Digital Works, January 2021. http://dx.doi.org/10.31986/issn.2689-0690_rdw.oer.1022.

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This series of open educational videos provides an in depth overview of various surgical preparation procedures. These instructional videos could be of interest to various medical and health science trainees in a variety of fields such as nursing or medicine. All patients featured in this video series have signed consent and release forms authorizing the release of these educational videos.

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Patel, Deep, Catherine Fedorka, and David Fuller. Shoulder Surgical Preparation Educational Video. Rowan Digital Works, January 2021. http://dx.doi.org/10.31986/issn.2689-0690_rdw.oer.1023.

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This series of open educational videos provides an in depth overview of various surgical preparation procedures. These instructional videos could be of interest to various medical and health science trainees in a variety of fields such as nursing or medicine. All patients featured in this video series have signed consent and release forms authorizing the release of these educational videos.

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Patel, Deep, Julio Rodriguez, Vishal Khatri, and David Fuller. Spine Surgical Preparation Educational Video. Rowan Digital Works, January 2021. http://dx.doi.org/10.31986/issn.2689-0690_rdw.oer.1021.

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This series of open educational videos provides an in depth overview of various surgical preparation procedures. These instructional videos could be of interest to various medical and health science trainees in a variety of fields such as nursing or medicine. All patients featured in this video series have signed consent and release forms authorizing the release of these educational videos.

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Patel, Deep, Eric Freeland, and David Fuller. Foot and Ankle Surgical Preparation Educational Video. Rowan Digital Works, January 2021. http://dx.doi.org/10.31986/issn.2689-0690_rdw.oer.1020.

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This series of open educational videos provides an in depth overview of various surgical preparation procedures. These instructional videos could be of interest to various medical and health science trainees in a variety of fields such as nursing or medicine. All patients featured in this video series have signed consent and release forms authorizing the release of these educational videos.

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Patel, Deep, Alisina Shahi, and David Fuller. Hand and Wrist Surgical Preparation Educational Video. Rowan Digital Works, January 2021. http://dx.doi.org/10.31986/issn.2689-0690_rdw.oer.1019.

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This series of open educational videos provides an in depth overview of various surgical preparation procedures. These instructional videos could be of interest to various medical and health science trainees in a variety of fields such as nursing or medicine. All patients featured in this video series have signed consent and release forms authorizing the release of these educational videos.

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Collins, E., J. Duguid, R. Henry, E. Karell, J. Laidler, S. McDeavitt, M. Thompson, M. Toth, M. Williamson, and J. Willit. Preparation of a technology development roadmap for the Accelerator Transmutation of Waste (ATW) System : report of the ATW separations technologies and waste forms technical working group. Office of Scientific and Technical Information (OSTI), August 1999. http://dx.doi.org/10.2172/12009.

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Jubin, Robert Thomas, Stephanie H. Bruffey, and Jacob A. Jordan. M3FT-17OR0301070211 - Preparation of Hot Isostatically Pressed AgZ Waste Form Samples. Office of Scientific and Technical Information (OSTI), October 2017. http://dx.doi.org/10.2172/1414692.

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Bruffey, Stephanie H., and Robert Thomas Jubin. Preparation of Four Large-format Hot Isostatically Pressed I-AgZ Waste Form Samples for Performance Testing. Office of Scientific and Technical Information (OSTI), September 2018. http://dx.doi.org/10.2172/1506807.

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