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1
Parkhurst, Michael. "Founder succession in small businesses." Thesis, Pepperdine University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3556877.
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<p> The purpose of this study is twofold. The first is to replicate and expand on previous studies by Rubenson and Gupta (1992, 1996) who introduced a contingency model for the initial succession of an organization. The second purpose is to verify that their model is applicable to organizations that are substantially smaller than the original 54 Fortune 1000 companies that were studied. The researcher used a qualitative research methodology to answer the following research questions. 1. Is the Contingency Model of the Initial Succession proposed by Rubenson and Gupta (1996) transferable to organizations of smaller size and lower revenues? 2. Were the founders of small sized organizations planning for their eventual succession? 3. What other factors came into play beyond those outlined by Rubenson and Gupta (1996) during the succession process? </p><p> The qualitative research methodology employed was a grounded theory research design utilizing personal interviews with the first successors of an organization. The researcher used a combination of structured and unstructured questions during the interviews of 15 successor CEOs about the process of succession from the founder to them as the next organizational leader. Participants in this study were chosen by a combination of purposeful sampling and chain referencing methods. All the participants and organizations in this study met the following criteria: (a) the interviewed successor must be the first leader after the founder, (b) the organizations must have been between $5 and $200 million dollars in annual revenue at the time of succession, (c) the organizations must have had 200 employees or less at the time of succession, and (d) the succession must either be in process or have happened within the last 5 years. </p><p> The results of this study suggest that founders who maintain a controlling equity position in their organizations are able to set the date and method of their succession with impunity. Only 6 of the 12 sub-factors in the model for the initial succession were confirmed in the sample population of this study. It is the authors conclusion that the proposed model by Rubenson and Gupta (1996) as it is currently constructed had minimal explanatory power in the target population of this study. Additionally, 6 themes were discovered during the interview process: founders are thinking in terms of how to cash out of the business rather than their legacy; founders are not planning for succession until it is thrust upon them by illness, old age, or by their family; founders did whatever they wanted because they were the majority shareholder; successors are not inclined to confront the founder; founders have a high level of self identification with the organization; and founders hung onto the organization because it was their hobby.</p>
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Ikwunze, A. P. "Andreas Vesalius - founder of scientific anatomy." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35794.
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Andreas Vesalius (31 December 1514–15 October 1564) was a Brabantian (in modern-day Belgium) anatomist, physician, and author of one of the most influential books on human anatomy, De humani corporis fabrica (On the Fabric of the Human Body). Vesalius is often referred to as the founder of modern human anatomy. He was professor at the University of Padua and later became Imperial physician at the court of Emperor Charles V.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35794
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Lewis, Colin A. "John Jolly : the Grahamstown bell founder." The Ringing World, 2002. http://www.ringingworld.co.uk.
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Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
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Matsuda, William J. "The founder reinterpreted: Kukai and Vraisemblant narrative." Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/7110.
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Lewis, Colin A. "New bells, new founder - Hillandale, South Africa." The Ringing World, 1999. http://hdl.handle.net/10962/d1012350.
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On the afternoon of Sunday 2nd May 1999, the first ring of bells cast in Africa, the bells at Hillandale, were rung for the first time. This is the second ring of bells to be installed in an institution established by the Order of the Holy Cross, and the seventh ring in South Africa and the tenth ring in Africa.<br>Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
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Heine, Janey. "Founder-Signatur in der genetisch aktiven Deutschen Fleckviehpopulation." kostenfrei, 2009. http://d-nb.info/1001449517/34.
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Heine, Janey. "Founder-Signatur in der genetisch aktiven Deutschen Fleckviehpopulation." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-112576.
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Thomson, Noel. "Bayesian mixture modelling of migration by founder analysis." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1468/.
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In this thesis a new method is proposed to estimate major periods of migration from one region into another using phased, non-recombined sequence data from the present. The assumption is made that migration occurs in multiple waves and that during each migration period, a number of sequences, called `founder sequences', migrate into the new region. It is first shown through appropriate simulations based on the structured coalescent that previous inferences based on the idea of founder sequences sufer from the fundamental problem that it is assumed that migration events coincide with the nodes (coalescent events) of the reconstructed tree. It is shown that such an assumption leads to contradictions with the assumed underlying migration process, and that inferences based on such a method have the potential for bias in the date estimates obtained. An improved method is proposed which involves `connected star trees', a tree structure that allows the uncertainty in the time of the migration event to be modelled in a probabilistic manner. Useful theoretical results under this assumption are derived. To model the uncertainty of which founder sequence belongs to which migration period, a Bayesian mixture modelling approach is taken, inferences in which are made by Markov Chain Monte Carlo techniques. Using the developed model, a reanalysis of a dataset that pertains to the settlement of Europe is undertaken. It is shown that sensible inferences can be made under certain conditions using the new model. However, it is also shown that questions of major interest cannot be answered, and certain inferences cannot be made due to an inherent lack of information in any dataset composed of sequences from the present day. It is argued that many of the major questions of interest regarding the migration of modern day humans into Europe cannot be answered without strong prior assumptions being made by the investigator. It is further argued that the same reasons that prohibit certain inferences from being made under the proposed model would remain in any method which has similar assumptions.
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Heibel, Martin. "Founder turnover in venture capital backed start-up companies." Weisbaden : Gabler, 2008. http://site.ebrary.com/id/10279681.
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Dean, Tyler. "Immigrant Founder Impact on Investment Benefits: Are Immigrant Founded Firms Good Societal, Investor and Market Stability Investments Relative to Native Founded Firms within the Fortune 500." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1868.
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Although researchers have determined that immigrants are valuable to our society and produced several studies that seek to explain immigrant benefits, little has been done to study whether or not immigrant-founded firms outperform native firms. This report determines whether or not immigrant entrepreneurs are good investments from societal, financial and market perspectives. It analyzes the impact of immigrant founders on 2017 Fortune 500 company performance from a societal, investment and market perspectives. To compile the data set, it utilizes immigration classification from the Center for American Entrepreneurship’s report on 2017 Fortune 500 company founders as a means of categorizing firm immigration status. In order to be included in the sample, there were several requirements: firms had to have a publicly listed security with a Capital IQ identification ID. These criteria resulted in 463 firms. Financial performance and innovation data were gathered through Capital IQ.
The analysis seeks to prove or disprove immigrant impact on performance in three categories. The first category, social impact, determined whether or not immigrant-founded firms are good societal investments. The second category, financial impact, determined whether or not immigrant-founded firms are good financial investments. The final category, market stability, determined whether or not immigrant-founded firms are good for overall market stability.
There were no statistically significant results for the dependent variables that were regressed. The was a range of R Values, regressions we run with both robust precision adjustments, and Winsor control methods were tested to no avail. This leads to the conclusion that immigrant-founded firms are not better investments than native founded firms at the Fortune 500 level. This held true in all models for each of the 3 theses compiled.
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黃冠萍 and Kwun-ping Flora Wong. "A study of MSH2 founder mutation in Hong Kong population." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41712316.
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O'Regan, S. J. "Serial founder entrepreneurs : careers and corridors, venture choices and outcomes." Thesis, University of Reading, 2016. http://centaur.reading.ac.uk/68998/.
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Entrepreneurship is important to the development of market economies, in particular founding or ‘starting-up’ new enterprises from scratch. Researchers constantly seek to break down the heterogeneous nature of entrepreneurial behaviour and one suggestion is to focus on experienced habitual entrepreneurs who have owned and managed multiple businesses. Studies have shown that the habitual typology can be divided into more homogenous sub-types. Researchers make a distinction between serial entrepreneurs who focus sequentially on one business at a time and portfolio entrepreneurs who own and manage multiple businesses simultaneously. More is known about portfolio entrepreneurship and drawing on this work a comprehensive set of postulates is beginning to emerge to explain the differences between novice, serial and portfolio entrepreneurs. Therefore, there is an urgent need to focus on the serial entrepreneur. The principal research question is: How is one venture related to the next in the series? Crucially, serial founders possess repeated experience of entry, exit and re-entry into entrepreneurship. Exit from a venture they founded can be positive or negative, i.e. the sale of a business or a managed closure or outright failure. Serial entrepreneurs have to manage the consequences of exit and also make decisions regarding re-entry. An improved understanding of their cyclical, flow-like processes, punctuated with the ‘critical incidents’ of entry and exit is key to understanding the economic selection of entrepreneurs and the accumulation and use of entrepreneurial human capital. Researchers expect ventures to be related and follow industry corridors. This study explores the nature of corridors and goes further by asking if ventures are imitative (i.e. serial entrepreneurs are more cautious) or innovative (i.e. bring new means-ends combinations into existence). Using the commentaries of persistent and active entrepreneurs and details of their ventures, it is clear that experienced founders use particular modes when creating new businesses. Also an unsuccessful exit through closure or outright failure is normal, a common occurrence in a serial career. The study of 112 start-ups reveals that the outcome of the previous venture has a strong bearing on what happens next. Successful exits often lead to start-ups in different industries thereby spreading innovation. Failure of a novice venture leads to a return to essentially the same opportunity to try again. Persistent serial entrepreneurs can recover from unaffordable losses by returning to employment. Exit conditions are also important in understanding portfolio entrepreneurship. Novice or serial ‘singleton’ entrepreneurs transition to portfolio entrepreneurship when their current business is not exited. Unrelated ventures are almost invariably unsuccessful, and consequently attempts to transition are not always successful. Serial entrepreneurs obtain economic benefit from previous ventures through the phenomenon of serial diversification, recycling and reusing knowledge and other resources. There is evidence of learning from experience over the course of a career, as the frequency of negative outcomes falls and each venture in the series survives longer, substantially increasing its chances of a successful exit. On the basis of these findings a new theory of serial entrepreneurship is proposed for further research, and recommendations are made for policy-makers, practitioners and entrepreneurship educators.
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Westerman, Kirsten M. "A Forgotten Founder: Franz Danzi and His Nine Woodwind Quintets." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1495807087574502.
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Cervantez, Brian. "Amon Carter: The Founder of Modern Fort Worth, 1930-1955." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4784/.
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From 1930 to 1955, Amon Carter, publisher of the Fort Worth Star-Telegram, exerted his power to create modern Fort Worth. Carter used his stature as the publisher of the city's major newspaper to build a modern city out of this livestock center. Between 1930 and 1955, Carter lobbied successfully for New Deal funds for Fort Worth, persuaded Consolidated Aircraft to build an airplane plant in the city, and convinced Burlington Railways to stay in the city. He also labored unsuccessfully to have the Trinity River Canal built and to secure a General Motors plant for Fort Worth. These efforts demonstrate that Carter was indeed the founder of modern Fort Worth.
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Wong, Kwun-ping Flora. "A study of MSH2 founder mutation in Hong Kong population." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41712316.
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Reeves, Karyn. "Founder effects and related issues in Host-viral association studies." Thesis, Reeves, Karyn (2013) Founder effects and related issues in Host-viral association studies. PhD thesis, Murdoch University, 2013. https://researchrepository.murdoch.edu.au/id/eprint/16565/.
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Viruses such as HIV which replicate rapidly and with high transcription error rates may evade immune detection by mutating at key positions within the viral amino acid sequence. Large-scale host-viral association studies are conducted to identify positions of possible escape mutation in response to host immune pressure, with this pressure predominantly governed by genes within the human leukocyte antigen (HLA) complex. When transmission of the virus is HLA-associated, however, standard tests of association can be confounded by the relatedness of contemporarily circulating viral sequences, as sequences descended from a common ancestor may share inherited patterns of polymorphisms, termed „founder effects‟. A number of model-based methods utilizing inferred phylogenetic trees estimated from the observed viral sequences have been proposed to correct for this confounding, although such methods are typically computationally intensive and require specialist software for their implementation. In this thesis we propose an alternative empirical approach based on principal components analysis (PCA) which can be implemented using widely available software, and which adapts and extends methods currently used to control for population stratification in case-control genome-wide association studies. To accommodate data with small proportions commonly observed in host-viral studies we implement the PCA-based controlling procedure within a logistic regression framework using novel formulations motivated by the Frisch-Waugh-Lovell Theorem and demonstrate their utility in detecting true associations whilst minimizing confounding generated by founder effects via simulation. The approach is then extended to the multivariate setting through the adaptation of well-known techniques which expand the scope of host-viral analyses by accommodating possible linkages within the HLA and viral data.
The thesis concludes with a discussion of issues arising from the application of tail-based rejection regions and false discovery rates in large-scale analyses based on pooled contingency tables with varying margins. We argue that constraints imposed by the margins have implications overlooked in the rigid application of techniques developed for tests based on statistics with continuous distributions, but by leveraging the scale of such analyses it may be possible to consider local deviations between observed and expected p-value distributions to better identify hypotheses of interest.
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Strömberg, Michaela, and Judith Bindala. "Born gobal firms in Northern Sweden A perspective of founder/top manager's characteristics and entrepreneurial orientation : A perspective of founder/top manager's characteristics and entrepreneurial orientation." Thesis, Umeå universitet, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57122.
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In previous research, it is stated that founders/top managers have an impact on the born global firms, meaning firms that become international directly from start or short time after establishment. The purpose of our thesis is to understand how the characteristics of founders/top managers and entrepreneurial orientation have an impact on the born global firm’s innovation and outcome. Based on foundations in earlier studies we identified a research gap that this thesis aims to fill. This thesis will contribute to the importance of a better understanding of how entrepreneurial orientation affects a born global firm’s innovation and outcome. Therefore, we outline the following research question; “How have the characteristics of the founder/top manager and entrepreneurial orientation an impact on the born global firm’s innovation and outcome?” In order to answer this question we review previous literature and construct a conceptual framework suitable for our study. When it comes to methodology, we apply an abductive approach, meaning that we start with a deductive approach and create a conceptual framework. Then along the way we move more towards an inductive approach since we want to develop existing theories and address theory implications for further studies. We use a qualitative research design and in-depth multiple case studies in order to get a deeper understanding of our research topic. Our empirical findings consist of three interviews with founders/top managers from three different born global firms in Umeå and Skellefteå. From these interviews, we conclude that all the three founders/top managers have an impact on the born global firm’s innovation and outcome. Consequently, we managed to perceive a link between the age of the firm and the level of entrepreneurial orientation. The implication was that the characteristics of the founder/top manager had a bigger impact on the youngest firm. The two other firms had more of a firm level behavior in terms of entrepreneurial orientation as they have been in operations for many years and have been established by two founders, unlike the younger firm. We could also find that number of founders, relations, brand image/position, and networking should be taken into consideration when it comes to characteristics of the founder/top manager and entrepreneurial orientation. The research gap we discovered within entrepreneurial orientation is complex and cannot be fully met by this thesis. As such, we recommend further research into this area. We suggest including employees from different departments within the born global firms when investigating the level of entrepreneurial orientation and how it affects innovation and outcome.<br>Centre for Inter-organizational Innovation Research
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SANGUINETI, Francesca. "Uscita imprenditoriale: Panoramica, Determinanti, e Fondatori abituali." Doctoral thesis, Università degli studi di Bergamo, 2021. http://hdl.handle.net/10446/185934.
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The growing literature dedicated to entrepreneurship has recently highlighted the importance of considering the founded firms’ exit not as an ending, negative stage in an entrepreneur’s work-life experience. Instead, the decision to leave one’s venture is a strategic choice undertaken for the firm’s sake or as a founding entrepreneur’s lifestyle choice and leading to various after-exit paths.
The thesis contributes to the stream of literature dedicated to the entrepreneurial exit and habitual entrepreneurship fields by (i) exploring the antecedents of the cross-road choice that founding entrepreneurs take right-after an acquisition occurs using a prospect theory approach and by (ii) investigating the characteristics that differentiate habitual founders from lifestyle entrepreneurs, borrowing from human capital theory and building on recent work in the field. From a methodological viewpoint, the thesis’ main contributions include (i) the use of a large dataset of 14,881 founders, created on the bases of the Crunchbase database (data.crunchbase.com), (ii) the focus on the very-after acquisition step taken by the founding entrepreneur and investigated in North America, Europe, and Asia, and (iii) the introduction of a relatively new unit of analysis -- habitual founders -- when discussing the characteristics of habitual entrepreneurship.
After introducing the thesis’ main concepts in Chapter 1, the various contributions are developed in the three following chapters. Chapter 2 offers a descriptive study of the current literature in the entrepreneurial exit field, with particular attention given to the individual voluntary choice of exiting the founded firm. Chapter 3 extends the previous study by focusing on the antecedents of the founder’s intention to leave or remain within the firm right after encountering its acquisition from external actors and investigating whether results hold across world regions. Chapter 4 centers the study on the differences leading entrepreneurs toward a lifestyle versus a multiple-ventures creation entrepreneurial approach. The Appendix offers a step-by-step explanation of the procedures undertaken to create the database; it is thought to be used by other researchers as a guideline toward the creation of a similar database.
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Coombs, Coutanya Moultry. "The Experience of Founder's Syndrome in Nonprofit Organizations Founded by Women." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7373.
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Gaps exist in the literature on knowledge of how founder behavior affects volunteers and employees in nonprofit organizations. Through exploration of founder relationships with volunteers and employees, this study fills some of those gaps and adds to the body of knowledge of how those relationships are perceived by founders, volunteers, and employees. The purpose of this narrative study was to address the question of the impact of founder behavior on founders, employees and volunteers in nonprofit women's organizations founded by African American and Caucasian women. The theory of psychological ownership was used as the framework to understand founder behavior. The qualitative narrative inquiry design consisted of interviews with 12 participants who work for nonprofit organizations that provide empowerment services to women. Themes such as control, lack of strategy and support, and silenced voices emerged as responses to the question of the impact of founder behavior on the organization. The results indicate that founders, employees, and volunteers report a need for clear policies, role assignments, procedures, and organizational goals. Founders are oblivious to the impact of their behavior on the organization and are not aware of the available resources that may exist in their communities. Implications include state level nonprofit policy that funds training for nonprofit organizations around the themes examined in this study. Recommendations for future research include examination of internal issues and structures related to an organization's growth. The result of this study may lead to increased understanding of perceptions of the operations of nonprofit organizations which may impact nonprofit organizations' abilities to meet the goals of their mission.
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Winbo, Annika. "Long QT syndrome in Sweden : founder effects and associated cardiac phenotypes." Doctoral thesis, Umeå universitet, Pediatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57724.
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Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p.R518X- commonly identified in Swedish LQTS index cases. Methods: Cases and families with LQTS (p.Y111C or p.R518X) and JLNS were recruited via regional clinical practices, national referrals to the Clinical Genetics laboratory, Umeå University Hospital, and a national inventory. Molecular genetics methods were used for case ascertainment. Clinical data was obtained via medical records, a questionnaire, and/or an interview. Electrocardiograms were manually assessed. In p.R518X heterozygotes intra-familial phenotypic variability (QTc and cardiac events) was assessed by analysis of sequence variants (modifier genes). The origins of the mutations p.Y111C and p.R518X were investigated using genealogical and haplotype analysis (microsatellite markers). In families sharing a common haplotype mutation age and associated prevalence was analyzed using ESTIAGE and DMLE computer software. Results: We identified p.Y111C (170 mutation-carriers) and p.R518X (101 mutation-carriers) as two major causes of LQTS/JLNS in Sweden. LQTS phenotype was revealed to be relatively benign in p.Y111C and p.R518X (annual incidence of life-threatening cardiac events, before therapy 0.05% and 0.04%, respectively). Gender-specific effects of genetic modifiers on phenotypic expression were seen. A founder origin, approximately 600-700 years ago in two northern river valleys was established for p.Y111C and p.R518X, and a high prevalence of LQTS founder descendants suggested. A minimum JLNS prevalence of 1:200 000 in preadolescent Swedish children was revealed. JLNS phenotype was mainly severe, with a cumulative incidence of life-threatening cardiac events of 53% (annual incidence rate before therapy 5%) and four sudden deaths. Possible founder effects regarding four KCNQ1 mutations; p.Y111C (8%), p.R518X (50%), c.572_576del (17%) and p.Q530X (8%) together explained 83% of the JLNS mutation-spectrum in Sweden, consisting of 8 KCNQ1 mutations. Conclusion: The high prevalence of p.Y111C- and p.R518X-related LQTS as well as JLNS revealed in Sweden could be explained by the combination of mild clinical phenotypes in heterozygotes and strong founder effects present during the population development of northern Sweden. Increased knowledge regarding the occurrence of LQTS and JLNS as well as mutation- and/or genotype-specific data constitute prerequisites for possible improvement of patient management.
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Singh, Virosha. "Unlearning in founder chief executive officers : a critical competence for success." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/64815.
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Founder-CEOÔs are highly influential in the growth of their businesses which operate in increasingly complex and turbulent environments. It is key for the businessesÔ survival that the Founder is adaptive and flexible in coping with changes in the external environment. Typically, Founder-CEOÔs bring certain knowledge and behaviours into the business, which may be unsuitable for the developing business context.
The literature shows a significant relationship between unlearning and change. Unlearning can facilitate the discarding of attachments to old knowledge and outdated behaviours. The literature, however, does not extensively discuss Founder-CEOs attachments and how they are unlearned. This study fills this gap in literature through the use of qualitative, exploratory research methods to gain deeper insights into the unlearning of unfavourable attachments of Founder-CEOÔs. A total of 15 semi-structured, in-depth interviews were conducted with Founder-CEOÔs of businesses from 14 different industries.
The key findings confirmed that Founder-CEOÔs are unfavourably attached to various knowledge structures, behaviours, attitudes, beliefs and skills. Certain external events transpire that force the Founder to unlearn these attachments during different stages of their businesses lifecycle. Letting go of a deeply entrenched attachment has an emotional impact on the Founder-CEO, as they find it difficult to let go of their preferred practises. However, the Founder-CEOÔs propensity for growth outweighs these emotions.
This study provides two major contributions towards the literature. Firstly, the findings provided the necessary insights to make adjustments to Rautenbach, Sutherland, & Scheepers (2015) original process model of unlearning an attachment for the context of Founder-CEOs. Secondly, and most importantly, a model for the Founder-CEO Unlearning Stages for Business Growth emerged from the findings. This model provides a means for the early identification of an unfavourable attachment through the processes of pre-unlearning, unlearning and post-unlearning. This will help the business transition to the next stage of its growth and improves its chances of survival.<br>Mini Dissertation (MBA)--University of Pretoria, 2017.<br>lt2018<br>Gordon Institute of Business Science (GIBS)<br>MBA<br>Unrestricted
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Witherow, John S. "The enigmatic founder : liberalism, republicanism and the thought of James Madison." PDXScholar, 1990. https://pdxscholar.library.pdx.edu/open_access_etds/4113.
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In the twentieth century the debate over the ideological origins of the founding period and early republic has resulted in a polarization of historical interpretations. Recently, the conflict has centered on historians who use either the liberal or classical republican paradigms to explain these eras. Scholars of the founding period have argued for the dominance of one political ideology or the other in the thought of important figures of this time. Unfortunately, this struggle has led to a narrow interpretation of arguably the greatest thinker in American History, James Madison. To the contrary, I hold Madison's thought was influenced by both liberal and classical republican ideas, and in this thesis I explore that interpretation.
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Kayim, Mehmet. "Founder Effect In Reintroduced Anatolian Mouflon Ovis Gmelinii Anatolica Valenciennes 1856 Populations." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12610015/index.pdf.
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Reintroduction of Anatolian mouflon population at Bozdag Protection &<br>Breeding Station to its former habitats(Emremsultan Wildlife Development Area in Ankara-Nallihan, and Karadag in Karaman) started in 2004. The magnitude of genetic change among Bozdag and reintroduced populations was evaluated by 11 microsatellite loci. Study populations revealed close results (±<br>st.dev.) &ndash<br>Bozdag population: nk = 2.9091 (±<br>1.1362), AE = 2.0250 (±<br>0.9537), Ho = 0.3830 (±<br>0.2717), He = 0.3956 (±<br>0.2746)<br>Nallihan population: nk = 2.9091 (±<br>1.1362), AE = 2.0592 (±<br>0.9451), Ho = 0.4086 (±<br>0.2977), He = 0.4052 (±<br>0.2767)<br>and Karadag population: nk = 2.5455 (±<br>1.1282), AE = 1.8809 (±<br>0.8758), Ho = 0.3388 (±<br>0.2775), He = 0.3607 (±<br>0.2716). Population differences for major genetic parameters were not significant (p ><br>0.05) by comparisons with paired t-test. Also, temporal change in genetic diversity for Bozdag population was investigated by comparison with temporal data. Temporal changes in genetic parameters were found to be not significant and possible causes for differences were argued. Additionally, genetic diversity and PI computations for different traps were verified and compared to uncover any potential bias due to the catching method. Comparisons did not reveal significant differences illustrating the homogeneity among traps. On the other hand, simulations detected the higher sensitivity of allelic diversity (A) to founder events than P and heterozygosity (Ho &<br>He) levels which supports heterozygosity excess method for bottleneck analysis. With the same simulation analysis, observed genetic diversity within reintroduced samples were found to be in the ranges of expectation (99% CI) indicating that translocated individuals were chosen randomly. Bottleneck analysis based on heterozygosity excess method (one-tailed test for heterozygosity excess: pSMM = 0.28515, pTPM = 0.06445, pIAM = 0.02441) and allele frequency distributions method (normal L-shaped) could not detect a recent genetic bottleneck for Bozdag population. However, simulations determined that these two methods are prone to type II error. Bottleneck detection failure for the study population is probably due to type II error instead of other sources of error like violations of model assumptions.
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Cheng, Hong Hocking. "Faculty as founder? : an examination of faculty's role in biomedical start-ups." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33079.
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Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology; and, (S.M.)--Massachusetts Institute of Technology, Sloan School of Management, 2005.<br>Includes bibliographical references (leaves 56-57).<br>Executive Summary: In this thesis, I examine faculty inventors' involvement in university spin-off firms formed to commercialize their inventions. In particular, I analyze the association between a faculty inventor's various roles in commercializing his/her invention and the performance of the ensuing fledging ventures. The study is based on a group of spin-off firms from MIT in the biomedical/life science sector between 1976 and 2003. Structured questionnaires were distributed to the 110 faculty inventors identified by the technology licensing office (TLO) in April 2005, yielding 31 valid responses covering 60 companies.<br>by Hong Hocking Cheng.<br>S.M.
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Manti, Stefano <1992>. "L'impatto del Capitale Umano del Founder sul successo di una Startup Innovativa." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/11599.
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La tesi si divide in tre capitoli. Il primo capitolo presenta le varie teorie riguardanti il mondo dell’entrepreneurship, cercando di cogliere gli approcci ed i fenomeni che stanno condizionando i business model delle imprese; negli anni dell’open innovation e della digitalizzazione infatti, la democratizzazione delle conoscenze e dei mezzi di produzione, accompagnata a un più semplice accesso al credito dovuto a fenomeni quali il crowdfounding ed il peer-to-peer lending, hanno permesso la nascita di molte nuove organizzazioni. Verrà quindi presentata l’importanza delle startup per la crescita e lo sviluppo economico, analizzando l’ambiente imprenditoriale internazionale ed esaminando nel dettaglio anche il conteso legislativo italiano ed i risultati raggiunti nel nostro paese. Il secondo capitolo è focalizzato invece sulla figura fondamentale di qualsiasi organizzazione, ossia l’imprenditore; si cercherà, attraverso un approfondito esame della letteratura, di spiegare come lo stock di capitale umano di un soggetto, accumulato in particolare attraverso il background educativo e l’esperienza lavorativa, possa condizionare la performance d’impresa. Il terzo capitolo infine, consiste in un’analisi empirica di un campione composto da 380 startupper e ha l’obiettivo di identificare un profilo imprenditoriale ideale, dal punto di vista educativo e lavorativo, capace di portare al successo un’organizzazione.
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Huusko, P. (Pia). "Predisposing genes in hereditary breast and ovarian cancer." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514254422.
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Abstract
In the present study, mutations in BRCA1 and BRCA2, the two major genes predisposing individuals to hereditary breast and ovarian cancer, were screened in Finnish and Turkish cancer families. Germline BRCA1 mutations were found in 7% (6/88) and BRCA2 mutations in 6% (5/88) of the Finnish families studied in Oulu. Two distinct BRCA1 (3745delT, 4216nt-2A→G) and three BRCA2 (999delTCAAA, 6503delTT, 9346nt-2A→G) mutations were identified, all of which are recurrently found in Finland. In the 15 Turkish cancer families studied, 5382insC and 5622C→T were detected in BRCA1, and 3414delTCAG in BRCA2. The novel 3414del4 mutation was found in a family with a case of male breast cancer.
In order to determine their ages and origin, 9 recurrent Finnish BRCA1 and BRCA2 mutations were studied further as regards haplotype conservation. Common origins approximately 18–80 generations (400–1600 years) ago were demonstrated for all studied mutations by partial haplotype sharing. The majority of the mutations showed geographical clustering, supporting the theory of regional founder effects. Four of the nine mutations are unique for Finland, whereas five have also been seen elsewhere. Mutations in the 5' end of BRCA1 tend to predispose individuals to ovarian cancer and those found in the 3' end to breast cancer. The age of ovarian cancer onset was significantly lower for BRCA1 (51 years) than for BRCA2 mutation carriers (61 years).
Germline TP53 mutations were sought in the Finnish breast cancer families found to be negative after BRCA1 and BRCA2 screening but who exhibited some phenotypic features of the Li-Fraumeni syndrome. The Asn235Ser was found in a family displaying Li-Fraumeni syndrome phenotype and the Tyr220Cys in a family with a milder Li-Fraumeni-like phenotype. The nature of both mutations as cancer-predisposing alterations was supported by means of loss of heterozygosity (LOH) and p53 immunohistochemistry studies.
Regional clustering of BRCA1 and BRCA2 founder mutations enables targeted genetic tests including especially those mutations characteristic of the birthplace of each patient. Additional genes are likely to explain a large proportion of the inherited susceptibility to breast cancer in particular. Germline TP53 mutations are expected to be found in the breast cancer families with other clinical features seen in the Li-Fraumeni syndrome.
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Fairbank, Anthony Bruce. "Ssu-ma I (179-251) : Wei statesman and Chin founder, an historiographical inquiry /." Thesis, Connect to this title online; UW restricted, 1994. http://hdl.handle.net/1773/10499.
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Thesis (Ph. D.)--University of Washington, 1994.<br>Vita. "The second part of the dissertation, consisting of two chapters, constitutes a translation and study of Chin shu 1, the 'Annals of Emperor Hsuan.'"--Abstract, 1. [2]. Includes bibliographical references (leaves [421]-432).
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Gabrielsson, Oliver, and Victor Mofjell. "Påverkar grundaren aktiekursens utveckling efter en IPO? : En studie av svenska biotech-bolag." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-37369.
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Marknaden för biotech-relaterade produkter är komplex och har ökat explosionsartat de senaste åren. Bolag som verkar inom denna bransch är ofta kapitalintensiva och tungt beroende avforskning för att lyckas i det långa perspektivet. Utbudet av biotech-relaterade produkter möteren ständigt överväldigande efterfrågan. Utmaningen ligger således ofta inte i att hitta sin marknadsnisch, utan snarare ligger den oftast djupt rotad i produktutvecklingen och R&D. För finansiering och underlättande av ägarbyte söker sig dessa bolag ofta till kapitalmarknaden (börsen). Vidare spelar grundaren en viktig roll vid stora händelser inom bolag, såsom en IPO. Grundarna sänder då ut unika signaler utefter sitt agerande och även enbart genom sitt närvarande. Denna studie syftar till att undersöka eventuella samband mellan grundarens position och rösträtt (genom aktieinnehav) inom ett biotech-bolag och aktiekursens utvecklingefter en genomförd IPO. Studiens urval består av 119 SME biotech-bolag som är noterade 2010-2017 på den svenska aktiemarknaden. Denna studie förser mottagaren med en analys av hur grundare inom den svenska biotech-marknaden påverkar aktiekursen efter en genomförd IPO. Studien uppvisar ett signifikant och positivt samband mellan grundarens position som “övrig ledande befattningshavare” (e.g. CRO, CSO, COO) och aktiekursens utveckling efter en IPO. Detta samband är starkast första handelsdagen samt en vecka efter IPOn. Vi fann även ett negativt samband mellan storleken på grundares aktieinnehav och kursutveckling den första handelsdagen. Resultatet har strategiska implikationer för hur företag sänder ut signaler vid en annalkande IPO samt hur marknaden tolkar dessa.<br>The market of biotech related products is complex and have experienced a substantial development in the recent years. Companies operating in this industry are often capital intensiveand heavily dependent on research in order to succeed, in a long-term perspective. The amount of biotech-related products is constantly facing an overwhelming level of demand. Therefore, finding a market niche is not usually the primary challenge, but instead the challenge lies deeply rooted within product development and R&D. To facilitate company financing and shifts in ownership, these companies are often drawn towards the capital market (the stock exchange). Furthermore, the founder plays a considerable role at major events within a company, such as IPOs. On such occasions, founders emit unique signals through their actions and mere presence. This study aims to explain the connection between founder position and voting rights (through shareholding) within a biotech-company, and the stock performance after an IPO. The sample consists of 119 SME biotech-companies, listed on the Swedish stock exchange between 2010-2017. The study provides the receiver with an analysis of how founders within the Swedish biotech-industry affects the stock performance after an IPO. The study shows a significant andpositive connection between founders with an “other governing position” (e.g. CRO, CSO,COO) and stock performance after an IPO. The connection is strongest by the first day of trading and after one week. We also found a negative connection between founder shareholding and the stock performance on the first day of trading. The result has strategic implications onhow companies send out signals during an IPO and how these signals are interpreted by the market.
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Kohn, Deborah Diane. "Effects of genetic variability and founder number in small populations of an annual plant." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286448.
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Cales, Kevin Ray. "FOUNDER OF METAPHYSICS OR ONTOLOGICAL DIALECTICIAN: MARTIN HEIDEGGER AND HANS-GEORG GADAMER ON PLATO." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/theses/2086.
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Martin Heidegger and Hans-Georg Gadamer both advanced a philosophical hermeneutics. These two thinkers, as teacher and student, share much in common, yet their hermeneutics are also divergent. I argue that their commonalities and differences are both markedly present in their contrasted interpretations of Plato. Heidegger argued that Plato was the founder of onto-theological metaphysics because Socrates’ program of education in the Republic required a reorientation of the soul to the Idea of the Good. In this educational reorientation of the soul to the Good, Heidegger claimed Plato effectively sublimated a-letheia to correctness. As his student, Hans-Georg Gadamer shared and attempted to further Heidegger’s interest in primordiality. However, whereas Heidegger “liquefied” Plato, Gadamer’s hermeneutics sought to recover an ontological Plato, one who stood against the tradition as a proponent of primordial a-letheia. Gadamer emphasized the transcendence of the Idea of the Good in Plato’s Republic as evidence that the Good is not an entity like all other Ideas. Through a reading of Plato’s Philebus, Gadamer argued that the Good discloses itself to humans engaged in dialectic in the beautiful unity and proportion of all things. Dialectic is disclosure and concealment of the Good in the matter under discussion. By interpreting Plato as a partner in ontology, Gadamer departed from Heidegger and his reading of the allegory of the cave while also offering a Heideggerian interpretation of Plato.
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Bähr, Andrea. "(Re)producing transgenic pigs for xenotransplantation – selection of founder animals and establishment of breeding herds." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138906.
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Rodgers, E. "Critical barriers and success factors to Irish University spin out activity from a founder perspective." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492501.
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The aim of this research study is to provide an understanding of the success factors and barriers impacting university spin-out activity in Ireland. The role of universities has evolved over recent years to include a remit of entrepreneurial activities in addition to their traditional roles of teaching and research. Many governments recognise the important role their local universities can play in helping to build a knowledge economy by producing commercial outputs from educational investment, in the form of technology transfer and university spin-out activity. In addition, changes in government funding of universities over recent years has forced universities to seek new sources of revenue. Thus, commercialisation activities can potentially provide this additional revenue stream required by many universities. Despite this increased emphasis by government on universities to promote spin-out activity there have been limited research studies which examine this activity outside the United States and those studies which do exist predominantly employ quantitative methods. Thus, this research study, employing qualitative methods, explores university spin-out activity across four universities in Ireland. The study examines university spin-out activity from the unique perspective of the individual academic founder through a social constructionist approach, using semi-structured interviews. The findings from the case study analysis of the universities are grounded in literature relating to technology transfer and the 'triple-helix' model of university-industrygovernment relations. Supplied by The British Library - 'The world's knowledge' 1:1 'II The barriers and success factors impacting spin-out activity are analysed from the experiences and perceptions of the academic founders of these spin-out companies. This study makes important contributions to the emerging literature in the area of university spin-out activity and provides an understanding of the barriers to university spin-out activity, providing a foundation from which to reduce these barriers and aiding future policy development.
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Roos, J. L. (Johannes Louw). "Genetic variation and clinical variables contributing to Schizophrenia in a Founder Population from South Africa." Thesis, University of Pretoria, 2014. http://hdl.handle.net/2263/44335.
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Thirty publications are submitted. They deal with findings of the genetic architecture of schizophrenia in an Afrikaner founder population and clinical related variables pertaining to this population.
The initial research findings supported the appropriateness of the Afrikaner population for mapping complex traits using both linkage and linkage disequilibrium (LD) approaches. Basic sample descriptors and cardinal symptoms of schizophrenia in the US and South African populations were equivalent. It was concluded that the results from our genetic study of schizophrenia in the Afrikaner sample will be applicable to other populations.
It was found that early non-psychotic childhood deviance (in the first ten years of life) distinguished a distinct subtype of schizophrenia patient, and that the form of early deviance manifested, was meaningful linked to later disease outcome; and that it may be a possible endophenotypic marker in schizophrenia but not in bipolar disorder.
Schizophrenia genetic research used linkage analysis, association studies and exome sequencing studies as it became available in the last few years. We addressed the role of the individual genes from the 22q11 locus (prototype CNV described in schizophrenia). Systematic screening of the 26 genes residing in this locus identified PRODH2, ZDHHC8, NOGO Receptor 1 (RTN4R) gene as contributing to schizophrenia risk associated with this region. Linkage genome-wide scans, using both less dense (10cM) and more dense scans (2cM), identified a locus on chromosome 1 and 13. Recent fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia (not included in the 30 publications). For the first time a probound with a uniparental disomy (UPD) of the entire chromosome 1, was identified, which further support the involvement of chromosome 1 in schizophrenia.
We confirmed the previous reported rate of 2% frequency of 22q11 deletions in adult schizophrenia Afrikaner patients and provided a two-stage screening protocol to identify these patients in clinical practice. As more patients were recruited for this study certain comorbid conditions became obvious including marijuana use/abuse and obsessive compulsive disorder (OCD) and obsessive compulsive symptoms (OCS).
Approximately half of the male patients and a quarter of the female patients used or abused marijuana. Male users of marijuana with prominent early non-psychotic deviant behaviour in the first 10 years of life had the lowest mean age of criteria onset (18.4 years) with a poor prognosis. The prevalence of OCD/OCS in this population was 13.2% and differs from other ethnic groups in South Africa, and was associated with significant psychopathology and poor prognosis.
As the research progressed the emphasis has changed from familial cases with the disease to sporadic cases (non-familial). We offered the first clear view of the genetic landscape of schizophrenia. We found that rare de novo structural mutations at many different loci are significantly enriched and contribute to schizophrenia vulnerability in sporadic cases with the disease. We also demonstrated that genes contribute to familial schizophrenia, while new mutations are less prominent.
The study of schizophrenia in the Afrikaner founder population has helped to clear the view of the genetic landscape of schizophrenia.<br>Thesis (DSc)--University of Pretoria, 2014.<br>tm2015<br>Psychiatry<br>DSc<br>Unrestricted
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Dulovits, Stephan, and Yonas Hadgu Tewelu. "New venture financing order and founder preference: A multi-case study of Austrian Tech startups." Thesis, Internationella Handelshögskolan, Jönköping University, IHH, Företagsekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48946.
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This study investigates the source of financing in Austrian tech startups and aims to identify the main factors that affect the decision making of these firms. In doing so, we aim to contribute to the relatively limited field of research conducted in Europe. In order to achieve the purpose of this study, we implemented a multiple case study method as the research design. For the purpose of this study, a literature review was used that generated a theoretical framework. This framework focuses on capital structure with the main emphasis being on the pecking order theory. Additionally, government financial support is included as a secondary priority. Together with the theoretical framework, our empirical findings i.e. data from the interviews with six companies, one email response, and two additional secondary data from an Austrian startup publication comprised the basis for our analysis. Our findings from the sample companies used in this study show that Austrian tech startups use internal funding as an initial source of financing their new venture. When it comes to the order of funding, our findings show that most of the startups used in this study utilized equity as a second source of financing after internal funding and before debt. However, when it comes to the preference of the founders, half preferred a financing order that is inline with the pecking order theory while the remaining half preferred otherwise choosing equity to debt. From this, three conclusions can be drawn. First, the limited funding options available affect the decision making and preference of the tech startups. Second, founders value the nonfinancial added value they can get from investors both when implementing and preferring a financing option. Third, the future growth potential and the long term strategy of the startups and their founders play a crucial role in the funding option they prefer to finance their venture. Additionally, when it comes to capital structure, we see that most Austrian tech startups used in this study do not have a set policy. When it comes to Government financial support (GFS), we see that financial support from the government plays a significant role in Austrian tech startup financing.
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Brandt, Mathias, and Stefan Stefansson. "The personality venture capitalist look for in founder: An artificial intelligence approach to personality analysis." Thesis, KTH, Industriell ekonomi och organisation (Inst.), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-246077.
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To date, the usual analysis of an entrepreneur personality is primarily a gut feeling of the venture capitalist and is hard to codify. This paper aims to explore in a qualitative way what it is about the characteristics and the personality of the entrepreneur that influences the investment made by the venture capitalists. These findings will then be used to discuss if an artificial intelligence application can be used to analyze the personality of entrepreneurs. The primary source of information for this paper is interviews with venture capitalists. The authors searched for similarities within the available literature on entrepreneurial personalities and found that the majority of the personality traits mentioned by the venture capitalist can be found in the literature. The research findings suggest that all venture capitalist value an entrepreneur that has passion for what she is doing and has the ability to get the job done. Additionally, most of the venture capitalist interviewed value an entrepreneur that is coachable, flexible, visionary, and is able to communicate that vision well. Finally, based on the results, the authors proposed a framework for how an artificial intelligence system can be structured to assess personalities of entrepreneurs.
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Kyser, Diana. "THROUGH THE LOOKING GLASS: COMPANY CULTURE AS A REFLECTION OF FOUNDER PERSONALITY IN ENTREPRENEURIAL ORGANIZATIONS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/436065.
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Business Administration/Entrepreneurship<br>Ph.D.<br>This dissertation explores the connection between founder personality and organizational culture in founder-led entrepreneurial companies. With a focus on how founder personality affects culture, it draws from the literature in upper echelon/top management teams, family business and organizational psychology – notably the Attraction-Selection-Attrition (ASA: Schneider, 1987) and Person-Organization fit (P-O: O'Reilly, Chatman, & Caldwell, 1991) theories. Using a combination of ethnographic, psychological and organizational data from the founders and employees of four small firms from multiple industries, and a broader survey study of 336 respondents from 23 firms, it finds support for O’Reilly et al., (2014)’s CEO Personality-Culture link in the small-company setting. It also validates two new findings: 1) that employee personality traits can trump founder personality as an influence on culture, and 2) that founder involvement can moderate the impact of founder personality on culture. The dissertation concludes with plans for further research into the personality-organizational culture effects and thoughts about the applicability of these results for founders and consultants.<br>Temple University--Theses
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Kauf, Tobias [Verfasser], Ann-Kristin [Akademischer Betreuer] Achleitner, and Christoph [Akademischer Betreuer] Kaserer. "The Heterogeneity of Founding-Family Firms: Governance, Firm Policy, Economics, and Ownership Dynamics in Lone Founder, Family Founder, and Heir Firms / Tobias Kauf. Gutachter: Ann-Kristin Achleitner ; Christoph Kaserer. Betreuer: Ann-Kristin Achleitner ; Christoph Kaserer." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1052308082/34.
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Väisänen, M. L. (Marja-Leena). "Fragile X syndrome in Northern Finland:molecular, diagnostic and population genetic aspects." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253779.
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Abstract
Fragile X syndrome, the most common inherited form of mental retardation syndrome, is caused by an expansion of the CGG trinucleotide repeat in the 5' UTR of the FMR1 gene, with concurrent hypermethylation of the region, which represses FMR1 expression. The syndrome is associated with the folate-sensitive chromosomal fragile site at Xq27.3 (FRAXA), where the gene responsible for the syndrome was first localized by linkage analysis using RFLP markers. In this study the linkage relationships of the RFLP markersat Xq27-28 and the characteristics of the CGG repeat expansion were investigated in northern Finnish fragile X families and molecular diagnostic methods were applied in order to improve diagnosis of the syndrome. Furthermore, the origin of fragile X mutations in the northern part of Finland was studied by haplotype analysis.
Linkage studies were performed in 34 northern Finnish fragile X families/pedigrees using a total of 15 RFLPs (defining 11 loci). A refined genetic map around FRAXA including five RFLP markers having recombination fractions of 0.04 or less with FRAXA was obtained in an international study of 112 affected families, containing linkage data on twelve northern Finnish families. Linkage analysis significantly improved carrier detection in fragile X families compared with previous cytogenetic methods used in diagnosis. The most efficient RFLP-based protocol for carrier detection was proposed, which is based on use of the most adjacent markers and a minimum number of restriction enzymes.
CGG repeat expansion of the FMR1 gene was investigated in original families collected for linkage studies and additional new ones. Large CGG repeat expansions (Δ > 500 bp) with concomitant methylation of the adjacent CpG island, i.e. full mutations, were found to be associated with mental retardation completely in males, but only 50% of the females having a full mutation were mentally impaired. Premutations (Δ < 700 bp) were found in healthy carriers. There was a size range of Δ = 500 to 700 bp, where the expansions could be either abnormally methylated or non-methylated, and it appeared that methylation is more important in determining the phenotype than the exact size of an expansion. Instability of the enlarged CGG repeats was detected, leading preferentially to size increases in successive generations. The instability of premutations was found to be stronger and the size increases larger in maternal than in paternal transmissions, and transition to a full mutation occurred only in female transmissions. In addition, the size of a maternal premutation was shown to have an important influence on the risk of its transition to a full mutation when transmitted. The critical premutation size leading invariably to full mutation in the offspring was found to be between Δ = 175 to 200 bp. In one of the studied families a rare contraction of a paternal premutation to a normal CGG repeat number in one of the daughters and further in her son was detected. Direct mutation analysis including measurement of the CGG repeat size and hypermethylation allowed unambiguous diagnosis of carriers and affected individuals in most cases.
Haplotype analysis using two tightly linked microsatellite markers flanking the CGG repeat mutation was performed in 60 unrelated northern and eastern Finnish fragile X families. A significant difference was found in allelic and haplotypic distributions between normal X and fragile X chromosomes. A single haplotype, which was present only in 8% of the normal X chromosomes, accounted for 80% of the fragile X chromosomes. This enrichment of one fra(X) mutation in the Finnish population suggests founder effect.
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Cameron, Emilie C. "Fruit Fly Pests of Northwestern Australia." University of Sydney, 2007. http://hdl.handle.net/2123/1711.
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Doctor of Philosophy(PhD),<br>Until recently, Northwestern Australia was thought to be relatively free of serious fruit fly pests. Although a noxious strain, present in Darwin since 1985, was widely believed to be an infestation of the Queensland fruit fly, Bactrocera tryoni, from the East coast, the fruit flies present outside this area were believed to be the benign endemic species, B. aquilonis. However, during the year 2000, infestations of fruit flies were discovered on major commercial crops in both Western Australia and the Northern Territory. It was not known whether these outbreaks were due to an invasion of the major pest species, Bactrocera tryoni, a change in the behaviour of B. aquilonis, or a hybridisation event between the two species. Finding the source of these outbreaks has been complicated by the fact that, since B. tryoni and B. aquilonis are virtually indistinguishable morphologically, it was not known which species are present in the region. Traditionally any tryoni complex fly caught in the Northwest was called B. aquilonis based solely on location. In order to get a good population profile of the region, an extensive trapping program was set up to include flies from urban areas, commercial crops and natural areas where the benign strain is thought to remain. Tests of genetic differentiation and clustering analyses revealed a high degree of homogeneity in the Northwest samples, suggesting that just one species is present in the region. The Northwest samples were genetically differentiated from the Queensland samples but only to a small degree (FST =0.0153). MtDNA sequencing results also showed a small degree of differentiation between these regions. A morphological study of wing shape indicated that there are some minor identifiable morphological differences between East coast and Northwest laboratory reared flies. This difference was greater than that seen between B. jarvisi populations across the same geographic range. The results suggest that the flies caught in the Northwest are a separate population of B. tryoni. Soon after pest flies were discovered in Darwin, a population became established in Alice Springs. This population had a low genetic diversity compared with Queensland and Darwin populations, and showed evidence of being heavily founded. In 2000, an outbreak was discovered in the nearby town of Ti Tree. Due to the geographic and genetic similarity of these populations, Alice Springs was determined to be the source of the Ti Tree outbreak. To investigate the founding of these populations, a program was developed to estimate the propagule size. Using a simulation method seven different statistics were tested for estimating the propagule size of an outbreak population. For outbreaks originating from populations with high genetic diversity, the number of alleles was a good estimator of propagule size. When, however, the genetic diversity of the source population was already reduced, allele frequency measures, particularly the likelihood of obtaining the outbreak population from the source population, gave more accurate estimates. Applying this information to the Alice Springs samples, it was estimated that just five flies were needed to found the major population in and around Alice Springs. For Ti Tree, the propagule size was estimated to be 27 flies (minimum 10). In 2000, a much larger outbreak occurred in the developing horticultural region of Kununurra in northern Western Australia. An important question for the management of the problem is whether there is an established fly population or the flies are reinvading each year. This population was found to have a large amount of gene flow from the Northern Territory. Within the Kununurra samples, one group of flies was genetically differentiated from all the other samples. This group came from a small geographic area on the periphery of Kununurra and appeared to be the result of an invasion into this area at the time when the population was building up following the dry season. A further threat to the Northwest horticultural regions comes from B. jarvisi. A recent increase in the host range of this species has lead to speculation that it may become a greater pest in Northwestern Australia. At the present time, protocols for the population monitoring and disinfestation of this species are not in place. Here it is shown that B. jarvisi eggs are more heat tolerant than B. tryoni eggs and that monitoring of B. jarvisi populations is possible using cue lure traps placed according to fruiting time and location of their favoured host, Planchonia careya.
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Cameron, Emilie C. "Fruit Fly Pests of Northwestern Australia." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/1711.
Full textAbstract:
Until recently, Northwestern Australia was thought to be relatively free of serious fruit fly pests. Although a noxious strain, present in Darwin since 1985, was widely believed to be an infestation of the Queensland fruit fly, Bactrocera tryoni, from the East coast, the fruit flies present outside this area were believed to be the benign endemic species, B. aquilonis. However, during the year 2000, infestations of fruit flies were discovered on major commercial crops in both Western Australia and the Northern Territory. It was not known whether these outbreaks were due to an invasion of the major pest species, Bactrocera tryoni, a change in the behaviour of B. aquilonis, or a hybridisation event between the two species. Finding the source of these outbreaks has been complicated by the fact that, since B. tryoni and B. aquilonis are virtually indistinguishable morphologically, it was not known which species are present in the region. Traditionally any tryoni complex fly caught in the Northwest was called B. aquilonis based solely on location. In order to get a good population profile of the region, an extensive trapping program was set up to include flies from urban areas, commercial crops and natural areas where the benign strain is thought to remain. Tests of genetic differentiation and clustering analyses revealed a high degree of homogeneity in the Northwest samples, suggesting that just one species is present in the region. The Northwest samples were genetically differentiated from the Queensland samples but only to a small degree (FST =0.0153). MtDNA sequencing results also showed a small degree of differentiation between these regions. A morphological study of wing shape indicated that there are some minor identifiable morphological differences between East coast and Northwest laboratory reared flies. This difference was greater than that seen between B. jarvisi populations across the same geographic range. The results suggest that the flies caught in the Northwest are a separate population of B. tryoni. Soon after pest flies were discovered in Darwin, a population became established in Alice Springs. This population had a low genetic diversity compared with Queensland and Darwin populations, and showed evidence of being heavily founded. In 2000, an outbreak was discovered in the nearby town of Ti Tree. Due to the geographic and genetic similarity of these populations, Alice Springs was determined to be the source of the Ti Tree outbreak. To investigate the founding of these populations, a program was developed to estimate the propagule size. Using a simulation method seven different statistics were tested for estimating the propagule size of an outbreak population. For outbreaks originating from populations with high genetic diversity, the number of alleles was a good estimator of propagule size. When, however, the genetic diversity of the source population was already reduced, allele frequency measures, particularly the likelihood of obtaining the outbreak population from the source population, gave more accurate estimates. Applying this information to the Alice Springs samples, it was estimated that just five flies were needed to found the major population in and around Alice Springs. For Ti Tree, the propagule size was estimated to be 27 flies (minimum 10). In 2000, a much larger outbreak occurred in the developing horticultural region of Kununurra in northern Western Australia. An important question for the management of the problem is whether there is an established fly population or the flies are reinvading each year. This population was found to have a large amount of gene flow from the Northern Territory. Within the Kununurra samples, one group of flies was genetically differentiated from all the other samples. This group came from a small geographic area on the periphery of Kununurra and appeared to be the result of an invasion into this area at the time when the population was building up following the dry season. A further threat to the Northwest horticultural regions comes from B. jarvisi. A recent increase in the host range of this species has lead to speculation that it may become a greater pest in Northwestern Australia. At the present time, protocols for the population monitoring and disinfestation of this species are not in place. Here it is shown that B. jarvisi eggs are more heat tolerant than B. tryoni eggs and that monitoring of B. jarvisi populations is possible using cue lure traps placed according to fruiting time and location of their favoured host, Planchonia careya.
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Wajiki, Yuichi. "Studies on Genetic Diversity and Its Maintenance in the Japanese Population of Japanese Crested Ibis (Nipponia nippon)." Kyoto University, 2016. http://hdl.handle.net/2433/215226.
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Wilson, W. James. "Moffitt Cancer Center: Leadership, Culture and Transformation." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7594.
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Purpose – The purpose of this project was to extrapolate knowledge of successful leadership practices, determine what led to and nurtured what became an integrated organizational culture and identify any decisions and/or transformational events that re-defined Moffitt Cancer Center’s (MCC) course or helped propel it to levels far beyond what was originally imagined. The aims of this study were discovery of the foundational factors and events that significantly impacted the creation, growth and evolution of the center, making MCC an institution of transformational change that had achieved state and national prominence.
Design – This was an exploratory study guided by a qualitative phenomenological research methodology using an interpretivist approach. Data was derived from twenty one-on-one interviews with people who had the specific knowledge and expertise necessary to obtain a better understanding of the leadership, culture and transformational events that transformed MCC into the institution that it is today. Interviewees included former and current MCC executive leaders, board members and key program directors, as well as the founder and two other former Speakers of the Florida House of Representatives. A literature review was conducted to explore founders, visionary leadership, organizational culture, and transformational organizations.
Findings – Key findings included discovery of the factors and events that impacted MCC’s growth and success. The interview process revealed three foundational factors pertaining to visionary leadership qualities of the founder and others, a mission-based culture and four transformational events that set MCC on a course of independence and self-governance. The literature review, with an emphasis on founders, visionary leadership, culture and transformational institutions, revealed useful information to draw comparisons and differences in the historical context of MCC’s growth and impact.
Value – MCC, created in Florida statute, existed as a private not-for-profit entity that, statutorily, served as an instrumentality of the state. As such, it had an interestingly distinct role as a hybrid organization that served a public and private sector need; while, very specifically, serving the cancer research and care needs of patients throughout the state and beyond. While the previously mentioned business literary research works are plentiful in the private and public sectors, a gap exists for hybrid organizations such as MCC. Future research could focus on organization founders who did not become part of the executive leadership structure.
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Trouten, E. R. Green Richard. "A select bibliography of primary and secondary literary data on the founder of Methodism, John Wesley." Theological Research Exchange Network (TREN), 1988. http://www.tren.com.
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Paré, Guillaume. "Genetic analysis of 100 loci for coronary artery disease and associated phenotypes in a founder population." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99196.
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Coronary artery disease (CAD) is a major health concern for both developed and developing countries. With a heritability estimated at around 50%, there is a strong rationale to better define the genetic contribution of CAD. In order to do so, my thesis project consists in the genetic analysis of over 1400 individuals from the Saguenay Lac St-Jean region using 1536 single nucleotide polymorphisms in 103 candidate genes for CAD. Using this data, suggestive linkage for HDL cholesterol was found on chromosome 1 and several significant associations were observed with lipoprotein-related traits as well as adiponectin plasma concentration, including two novel associations.
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Cloete, Ruben Earl Ashley. "Investigations of Renin-Angiotensin Aldosterone System (RAAS) genes in hypertrophy in hypertrophic cardiomyopathy (HCM) founder families." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/21880.
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Thesis (MScMed)--Stellenbosch University, 2008.<br>ENGLISH ABSTRACT: In hypertrophic cardiomyopathy (HCM), an autosomal dominant disorder, hypertrophy is variable
within and between families carrying the same causal mutation, suggesting a role for modifier genes.
Associations between left ventricular hypertrophy and left ventricular pressure overload suggested
that sequence variants in genes involved in the Renin-Angiotensin Aldosterone System (RAAS) may
act as hypertrophy modifiers in HCM, but some of these studies may have been confounded by,
amongst other things, lack of adjustment for hypertrophy covariates.
To investigate this hypothesis, twenty one polymorphic loci spread across six genes (ACE1, AGT,
AGTR1, CYP11B2, CMA and ACE2) of the RAAS were genotyped in 353 subjects from 22 South
African HCM-families, in which founder mutations segregate. Genotypes were compared to 17
echocardiographically-derived hypertrophic indices of left ventricular wall thickness at 16 segments
covering three longitudinal levels. Family-based association was performed by quantitative
transmission disequilibrium testing (QTDT), and mixed effects models to analyse the X-linked gene
ACE2, with concurrent adjustment for hypertrophy covariates (age, sex, systolic blood pressure (BP),
diastolic BP, body surface area, heart rate and mutation status).
Strong evidence of linkage in the absence of association was detected between polymorphisms at
ACE1 and posterior and anterior wall thickness (PW and AW, respectively) at the papillary muscle
level (pap) and apex level (apx). In single-locus analysis, statistically significant associations were
generated between the CYP11B2 rs3097 polymorphism and PW at the mitral valve level (mit) and
both PWpap and inferior wall thickness (IW)pap. Statistically significant associations were
generated at three AGTR1 polymorphisms, namely, between rs2640539 and AWmit, rs 3772627 and
anterior interventricular septum thickness at pap and rs5182 and both IWpap and AWapx.
Furthermore, mixed effects model detected statistically significant association between the ACE2
rs879922 polymorphism and both posterior interventricular septum thickness and lateral wall
thickness at mit in females only.
These data indicate a role for RAAS gene variants, independent of hypertrophy covariates, in
modifying the phenotypic expression of hypertrophy in HCM-affected individuals.<br>AFRIKAANSE OPSOMMING: Hipertrofiese kardiomiopatie (HCM), ‘n autosomale dominante afwyking, toon hoogs variërende
hipertrofie binne en tussen families wat dieselfde siekte-veroorsakende mutasie het, hierdie dui op
die moontlike betrokkenheid van geassosieerde modifiserende gene. Assosiasies tussen linker
ventrikulêre hipertrofie en linker ventrikulêre druk-oorlading stel voor dat volgorde variasies in gene
betrokke in die Renin-Angiotensin Aldosteroon Sisteem (RAAS) mag optree as hipertrofie
modifiseerders in HCM. Sommige van hierdie soort studies is egter beperk omdat hulle nie
gekompenseer het vir kovariante van hipertrofie nie.
Om hierdie hipotese te ondersoek, is die genotipe bepaal by een-en-twintig polimorfiese lokusse,
verspreid regoor ses RAAS gene (ACE1, AGT, AGTR1, CYP11B2, CMA and ACE2), in 353
kandidate vanuit 22 Suid-Afrikaanse HCM-families in wie stigter mutasies segregeer. Genotipes was
vergelyk met 17 eggokardiografies afgeleide hipertrofiese indekse van linker ventrikulêre wanddikte
by 16 segmente wat oor drie longitudinale vlakke strek. Familie-gebaseerde assosiasies was
bestudeer deur kwantitatiewe transmissie disequilibrium toetsing (QTDT) en gemengde effek
modelle om die X-gekoppelde geen ACE2 te analiseer, met gelyktydige kompensasie vir hipertrofie
kovariate (ouderdom, geslag, sistoliese bloed druk (BP), diastoliese BP, liggaamsoppervlak area,
hartritme en mutasie-status).
Sterk indikasies van koppeling in die afwesigheid van assosiasie is waargeneem tussen ACE1
lokusse en posterior wanddikte (PW) asook anterior wanddikte (AW) by die papillêre spier vlak
(pap) en die apeks vlak (apx). In enkel-lokus analises is statisties-betekenisvolle assosiasies gevind
tussen die CYP11B2 rs3097 polimorfisme en PW by die mitraalklep vlak (mit) en beide die PWpap
en inferior wanddikte (IW)pap. Statisties-betekenisvolle assosiasies was verder gevind by drie
AGTR1 polimorfismes, naamlik, tussen rs2640539 polimorfisme en AWmit, rs3772627 en die
anterior interventrikulêre septumdikte (aIVS) by die pap en rs5182 by beide die IWpap en AWapx.
Gemengde-effek modelle het verder assosiasies aangetoon tussen die ACE2 rs879922 polimorfisme
en die posterior interventrikulêre septumdikte en die laterale wanddikte by die mit, slegs in vrouens.
Hierdie data dui op ‘n kovariaat-onafhanklike rol vir RAAS genetiese variante in die modifisering
van die fenotipiese uitdrukking van hipertrofie in HCM-geaffekteerde individue.
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Kempster, Michelle. "Leading for sustainability: an exploratory study of founder transitions in nonprofit organisations in the Western Cape." Master's thesis, Faculty of Humanities, 2019. https://hdl.handle.net/11427/31645.
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The sustainability of the nonprofit sector is vital to social development in South Africa. The sector plays a significant role in the provision of social protection and developmental services to the most vulnerable citizens of our country. Nonprofit organisations operate in an environment which is often complex, volatile and uncertain. With the increasing demand for accountability, sound governance and ever more creative fundraising models, leading and managing nonprofits has become particularly challenging. Most nonprofits survive infancy because of the incredible passion and commitment of nonprofit founders, towards their unwavering belief in a social cause. Without their energy and charisma, the nonprofit sector would not be as influential and substantial as it is today. For an organisation to mature and increase its desired impact, the founder energy needs to be refined and combined with new skills that suit a larger and more effective organisation. However, if this does not happen, some organisations become dependent on the founder, causing risk of trauma, stagnation or demise, particularly when the founder moves on. Even where an organisation remains in operation, a founder transition may result in unnecessary damage to all stakeholders, if not planned and managed well. Founder transitions in nonprofit organisations has not been given the recognition in South African literature that it deserves. Therefore, the purpose of this study is to answer the question, “How do nonprofit organisations in South Africa experience founder transitions?” In this study, an exploratory qualitative research design was used in order to gain a deeper understanding of the experience of founder transitions in nonprofit organisation. Based on a literature review on founder transitions and related succession planning and founder’s syndrome in the nonprofit sector, the research questions and a research methodology were chosen. Ethics clearance was given by the University of Cape Town and a sample of 17 participants were selected to take part in the study by purposive sampling. The participants, all senior leaders in the nonprofit sector with experience of founder transitions, represented eight organisations in the Western Cape. The data was collected using a semi-structured interview schedule, and analysed using Tesch’s (1990) steps of data analysis. The contribution this study makes is to add to the understanding of the founder transition planning and management practices of South African nonprofit organisations, exposing both the opportunities and challenges experienced during the transition. The study makes a number of findings including: 1) the level of risk and challenge to nonprofit organisations during the founder transition is underestimated by their leaders, 2) nonprofit leaders feel they are ill equipped to manage founder transitions effectively, 3) founder transitions are a particularly emotional experience requiring relationships to be managed skillfully, 4) succession planning is a neglected risk management practice, impacting on the magnitude of the founder transition, 5) nonprofit founders and boards are not certain of their distinct roles during the founder transition, which can result in poor leadership and management of the founder transition, and 6) effective founder transitions constitute an additional cost to nonprofit organisations which should be budgeted for. Based on these findings, the study concludes with recommendations for nonprofit boards on how to improve the planning and management of founder transitions in nonprofit organisations.
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Sarantaus, Laura. "Germline mutations of BRCA1 and BRCA1 genes : founder effects and contribution to ovarian carcinoma in Finland." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/sarantaus/.
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Badrinath, Krishan. "Founder Cell and Myoblast Interactions during IFM Myogenesis in Drosophila: the Regulation of Myoblast Proliferation, Fusion, and Fiber Formation." Miami University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=miami1229615387.
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Vašíčková, Pavla. "Účetnictví zahraniční organizační složky." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-76387.
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The thesis deals with the accounting of Czech company's branch established in Slovak Republic. The first part is rather theoretical, it shows the branch from a legal point of view and consequently in terms of accounting from the perspective of the founder of the branch itself and from the perspective of the foreign branch. Other chapters are devoted to the practical example of the Czech company's branch established in Slovakia. The branch and its founder are defined in the second chapter of the thesis. The third part deals with the accounting of Slovak branch that means with the various operations carried out during the accounting period from the opening of the accounting books through regular transactions to closing the accounting books. The third chapter also describes how to capture branch in the accounting of its founder. The last part is devoted to correct mistakes, respectively infringement of the Slovak accounting standards, which were found in the accounting of the Slovak branch.
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Bähr, Andrea [Verfasser]. "(Re)producing transgenic pigs for xenotransplantation - selection of founder animals and establishment of breeding herds / Andrea Bähr." München : Verlag Dr. Hut, 2011. http://d-nb.info/1018983007/34.
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