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Dissertations / Theses on the topic 'FOX1'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Gabriel, Frédéric. "Etude fonctionnelle de la β-oxydation chez la levure pathogène opportuniste Candida lusitaniae : caractérisation d’une voie mitochondriale et peroxysomale Fox2p-dépendante et mise en évidence d’une voie peroxysomale alternative Fox2p-indépendante de catabolisme des acides gras". Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21896/document.

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Les levures Candida sont des pathogènes opportunistes émergents. Après phagocytose macrophagique, C. albicans reprogramme son métabolisme pour faire face à une carence carbonée et induit 2 voies métaboliques, le cycle du glyoxylate et la β-oxydation. Notre objectif est d’étudier le lien entre β-oxydation, capacité de résistance à la phagocytose et virulence dans notre modèle biologique C. lusitaniae. Chez les levures Ascomycètes la β-oxydation, essentielle pour dégrader les acides gras (AG), est présumée être exclusivement peroxysomale.Nous avons construit 3 mutants nuls chez C. lusitaniae : i

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古賀, 牧土. "新規リプログラミング制御因子Foxd1の同定と機能解析". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188833.

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Milewski, David E. "Forkhead Box F1 (FOXF1) is an essential effector of the PAX3/FOXO1 oncogene in human alveolar rhabdomyosarcoma." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563295140262318.

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Mourad-Agha, Hanna. "Molecular analysis of the role of FoxR in regulation of the foxA gene of Salmonella enterica serovar Typhimurium." Thesis, University of Reading, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518217.

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Goda, Chinmayee. "Transcriptional regulation of lung diseases by Fox proteins." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159213479759453.

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6

Black, Markaisa. "FOX proteins as novel negative regulators of lung fibrosis and mitochondrial respiration." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530270199796482.

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Goatly, Alison. "FOXP1 abnormalities in lymphoma." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611626.

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Pasche, Bastian. "Promotoranalyse und Expressionsstudien der murinen und humanen fork head homologen Gene Foxq1 und FOXQ1." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964105225.

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Yaklichkin, Sergey Yu, Diana Darnell, Maricela Pier, Parker Antin, and Sridhar Hannenhalli. "Accelerated evolution of 3'avian FOXE1 genes, and thyroid and feather specific expression of chicken FoxE1." BioMed Central, 2011. http://hdl.handle.net/10150/610379.

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BACKGROUND:The forkhead transcription factor gene E1 (FOXE1) plays an important role in regulation of thyroid development, palate formation and hair morphogenesis in mammals. However, avian FOXE1 genes have not been characterized and as such, codon evolution of FOXE1 orthologs in a broader evolutionary context of mammals and birds is not known.RESULTS:In this study we identified the avian FOXE1 gene in chicken, turkey and zebra finch, all of which consist of a single exon. Chicken and zebra finch FOXE1 are uniquely located on the sex-determining Z chromosome. In situ hybridization shows that c

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Deng, Meihong. "Proteolytic cleavage of FOXM1 by caspases /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36396503.

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Deng, Meihong, and 邓美虹. "Proteolytic cleavage of FOXM1 by caspases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010675.

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Tse, Yuen-yu Belinda, and 謝宛余. "Expression of FOXP1 in breast cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193527.

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Objectives: Forkhead box protein P1 (FOXP1) is a transcription factor, and a member of the P-subfamily of forkhead box transcription factor and regulate transcription of a subset of genes that involved in various cellular events. It plays a critical role in regulating cell growth and proliferation, differentiation, embryogenesis, adult tissue homeostasis, and possibly tumorigenesis. Predominant nuclear localisation of FOXP1 protein is commonly expressed at low level in normal tissues and upregulated in proliferative cells. Studies have demonstrated that the loss of FOXP1 expression and cytopla

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13

Karunarathna, H. R. Upekha. "Post translational modifications of FOXM1 expression." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/52459.

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FOXM1 plays an important role during mitosis and DNA damage response, and its overexpression has been implicated in breast cancer initiation and drug resistance. However, only a limited knowledge is available as to how FOXM1 expression is regulated by chemotherapeutic drugs and how these regulatory mechanisms are overcome during acquisition of resistance. Accumulating evidence shows that FOXM1 is regulated post-translationally in response to different cues that are received by the cell, eg: during the cell cycle and drug resistance. My study shows that FOXM1 is also modified post-translational

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Farris, Corrie Lynn. "FOXO1 Expression in Human Pituitary Adenomas." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/1034.

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FOXO1 is a forkhead transcription factor that inhibits proliferation and promotes apoptosis. It regulates genes that are involved in many diverse processes, including regulation of cell proliferation and cancer. The goal of our research is to understand FOXO1 and the role that it plays in human pituitary adenomas. Three objectives were outlined in this project to help determine the expression of FOXO1 in human pituitary adenomas. The first objective of this project was to analyze the spatial and temporal pattern of FOXO1 during mouse pituitary development. Objective one results showed th

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15

Smith, Sierra Marie. "FoxO1 Induces Apoptosis in Skeletal Myotubes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1270334870.

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Bullock, Martyn. "Characterisation of a forkhead transcription factor, FOXE1." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55712/.

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FOXE1, a forkhead transcription factor, plays an essential role in the development of the thyroid and hair follicle. Loss-of-function FOXE1 mutations cause aberrant morphogenesis of both tissues, apparently due to a defect in cell migration. In the mature thyroid, FOXE1 plays an essential role in the control of thyroid hormone synthesis, modulating both thyroglobulin and thyroid peroxidase gene expression. Several studies have shown there is considerable inter-individual variability in thyroid hormone levels, and this is due at least in part to genetic factors. One of the main features of the

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17

Kongsema, Mesayamas. "The regulation of FOXM1 in breast cancer." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44118.

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Breast cancer is the most commonly diagnosed cancer in women worldwide. In the UK, there is 1 in 8 of women that have a risk of being diagnosed with breast cancer in a lifetime. Clinically, the common treatment using for breast cancer therapy are combinations of surgery, radiotherapy, endocrinal (hormonal) therapy and chemotherapy. The DNA damaging agent epirubicin has been shown to be an effective chemotherapeutic drug for breast cancer treatment. Nevertheless, there are more than 90% of patients with metastatic cancer that found to be resistant to the drug. FOXM1 is a transcription factor th

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Lindmayer, Christian [Verfasser], and Sebastian [Akademischer Betreuer] Grundmann. "Die Rolle des Transkriptionsfaktors FoxP1 beim Blutgefäßwachstum." Freiburg : Universität, 2021. http://d-nb.info/1236846036/34.

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Millour, Julie. "FOXM1 in breast cancer and drug resistance." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/17849.

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Endocrine agents have become the primary adjuvant treatment for breast cancer. In addition to endocrine therapy, cytotoxic chemotherapeutic agents have also been frequently used in the neoadjuvant and adjuvant settings, to reduce tumour size prior to surgery or to reduce the chance of relapse or metastasis. However, patients can be resistant to endocrine and chemotherapeutic agents, or become resistant after long term treatment. In this study, I investigated the role and the regulation of FOXM1 in the sensitivity and resistance to the endocrine agent, tamoxifen, and the cytotoxic chemotherapeu

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20

Martynoga, Ben. "Foxg1 : a pleiotropic regulator of telencephalic development." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29250.

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This thesis focuses on the role of the forkhead box factor Foxg1 in the development of the vertebrate telencephalon. Mice mutant for <i>Foxg1</i> exhibit multiple telencephalic defects demonstrative of an important pleiotropic role of rFoxg1 in telencephalic organogenesis. Severe hypoplasia of the null mutant telencephalon demonstrates that Foxg1 is required for the regulation of telencephalic growth. Experiments descried in this thesis provide the most systematic study to date of the mechanisms by which Foxg1 regulates this process. Broadly, the results demonstrate that Foxg1 is required to m

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Kapali, Jyoti. "DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1485.

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Various mouse models have allowed for identification of several transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary hormone deficiency may occur due to loss of a single hormone causing isolated hormone deficiency or several hormones leading to combined pituitary hormone deficiency (CPHD). Defects in genes such as LHX3, LHX4, RPX, PROP1, and PIT1 are known to contribute to CPHD in humans. FOXO1 is a member of a large fam

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Pellén, Angelica. "Oh foxy lady, where art thou? : A corpus based analysis of the word foxy, from a gender stereotype perspective." Thesis, Växjö University, School of Humanities, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-2569.

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<p>Abstract</p><p>The aim of this essay is to establish whether or not the word foxy can serve to illustrate gender differences and gender stereotypes in English. The analysis is conducted by using one American English corpus and one British English corpus in order to make a comparison of the two English varieties. Apart from the comparative study, foxy is examined and categorized according to gender and a number of features to help answering the research questions which are:</p><p>• What difference in meaning, if any, does the word foxy carry when used for males, females and inanimate things?

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Miller, Gregory E. "The Saxophone Music of Frederick Fox: An Annotated Bibliography with an Analysis of S.A.X. for Solo Alto Saxophone and Saxophone Quartet." Thesis, connect to online resource, 2008. http://digital.library.unt.edu/permalink/meta-dc-9751.

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24

Naïmi, Mourad. "Métabolisme et vieillissement : de Fox0 à la mitochondrie." Nice, 2007. http://www.theses.fr/2007NICE4016.

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Les cellules eucaryotes sont étroitement dépendantes des mitochondries pour leur production d’énergie. Par ailleurs, la chaîne respiratoire représente la principale source de radicaux libres, mutagènes pour l’ADN nucléaire ou mitochondrial. Ainsi, les fonctions mitochondriales sont au coeur du processus de vieillissement et de la physiopathologie de maladies à révélation relativement tardive, diabète de type 2 ou maladies neuro-dégénératives. Le rôle majeur de FoxO1 et de ses homologues dans la protection contre le stress oxydant et les dommages de l’ADN, et ainsi dans la détermination de la l

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Ling, Alisha Viva. "The Role of Hepatic FoxO1 in Insulin Resistance." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463131.

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Metabolic syndrome is a major health concern in the US, affecting a third of all adults and amplifying the risk of cardiovascular disease and diabetes. The central pathophysiological root of metabolic syndrome is widely considered to be insulin resistance, though the mechanisms linking insulin resistance to this clinical constellation of obesity, dyslipidemia, hypertension and hepatic steatosis are poorly understood. In insulin resistance, insulin suppression of the forkhead box protein O1 (FOXO1) transcription factor is lost, and FoxO1 remains inappropriately over-active. FoxO1 has an establi

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Pomeranz, Karen M. "Regulation of FoxO transcription factors in breast cancer." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4253.

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Breast cancer is the world's most prevalent cancer. Although several drugs and chemotherapeutic strategies have been developed to tackle breast cancer, to date most patients eventually acquire resistance to these anticancer therapies. Therefore, identifying ways to increase the efficiency of currently used chemotherapeutic drugs and the development of new drugs for breast cancer treatment is essential. One way to achieve this goal is by identifying cellular targets which play a pivotal role in tumourigenesis and tumour progression. Paclitaxel belongs to a class of naturally occurring anti micr

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Kwok, Jimmy. "The development of FOXM1 as a therapeutic target." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5940.

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The Forkhead Box M1 (FOXM1) transcription factor is an important master cell cycle regulator that can control a wide spectrum of downstream target genes involved in apoptosis, metastasis, DNA repair, oxidative stress, G1/S and G2/M cell cycle transition. Elevated expression or activity of FOXM1 is correlated with poor prognosis in breast cancer patients. In this study, I demonstrated that the novel thiazole antibiotics - thiostrepton selectively induces cell cycle arrest and cell death in breast cancer cells through down-regulating of FOXM1 at the transcriptional and gene promoter levels. Furt

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Halvorsen, Stina, and Hanna Mårtensson. "Sveriges Television vs : Fox News." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-1450.

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<p>Abstract</p><p>Författare: Stina Halvorsen, Hanna Mårtensson</p><p>Handledare: Eva-Lotta Frid</p><p>Titel: Sveriges Television vs. Fox News, en jämförelse av</p><p>nyhetsrapporteringen kring Pakistankonflikten</p><p>Ämne: Medie- och kommunikationsvetenskap</p><p>År: 2007</p><p>Syfte: Syftet med uppsatsen är att blottlägga vilka skillnader och likheter</p><p>som finns i nyhetsrapporterandet mellan kanalerna gällande den specifika</p><p>händelsen i Pakistan.</p><p>Metod: Vi använder ett kritiskt hermeneutiskt förhållningssätt och tillämpar</p><p>sedan kvalitativ metod i form av diskursanalys

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Reynolds, Glen David. "Was George Fox a gnostic?" Thesis, University of Sunderland, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399190.

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The critique of Quakerism made by John Owen (Puritan Vice-chancellor of Oxford University) in tracts published in 1655 and 1679 was that Quaker theology renewed aspects of Gnosticism, a theology interpreted by patristic commentators as a Christian heresy. Owen's comparison was confined to the Quaker concepts of Light and spiritual perfection (which Owen viewed as being similar to the nature and function of Gnostic revelatory knowledge). This thesis argues that Fox's theological message (and in particular his interpretation of the concept of revelatory Light) incorporated a remarkably similar s

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Kinkade, Natalie. "Fox Dreams and Other Essays." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1620380678047587.

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Hill, Stewart Lloyd. "Fox Lake First Nation land use and occupancy : living memory of the Fox Lake Cree." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1993. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/MQ32129.pdf.

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Dormann, Andreas [Verfasser], Lars-Oliver [Akademischer Betreuer] Klotz, and Wilhelm [Akademischer Betreuer] Stahl. "Modulation der Wirkung von FoxO-Transkriptionsfaktoren auf Promotoren von FoxO-Zielgenen: Einfluss antidiabetischer Pharmaka / Andreas Dormann. Gutachter: Lars-Oliver Klotz ; Wilhelm Stahl." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1077063342/34.

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Loring, Eric. "The cost-benefit relations of modern Inuit hunting : the Kapuivimiut of Foxe Basin, N.W.T. Canada." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24091.

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Economic data concerning the costs and benefits of Inuit subsistence in the Igloolik region of Nunavut were collected during the summer of 1992. The purpose of the research was to develop a method of valuation to showcase the high "profit", in economic terms, that harvested country food provides.<br>Wildlife harvesting in Inuit communities represents a traditional way of life which is threatened by the increasing expansion of wage employment, industrial development and the availability of store bought food. However, rather than having a marginalizing effect, these changes make subsistence hunt

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Zhao, Fung, and 趙楓. "Role of FOXM1 in ovarian cancer tumorigenesis and chemoresistance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/211053.

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Ovarian carcinoma is the most lethal gynecological malignancy. The high relapse and mortality rates are attributable to late diagnosis and development of drug resistance. Identifying novel prognostic and therapeutic targets for ovarian carcinoma is crucial for improving patients' long-term survival rate. Forkhead box protein M1 (FOXM1), which is a widely studied member of the FOX superfamily of proteins, participates in cell proliferation and apoptosis affecting the developmental function of many organs. Recently, there has been emerging evidence supporting the biological significance of FO

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Gemenetzidis, Emilios. "The role of FOXM1 in oral squamous cell carcinoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/492.

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FOXM1 transcription factor regulates the expression of a multitude of genes, which are important for cell proliferation, mitosis, and differentiation. Although it is abundantly expressed in majority of human solid tumours, its role in early stages of human neoplasia remains unclear. Oral squamous cell carcinoma (OSCC) is characterized by sequential genomic alterations, which lead to invasive malignancy. In this study, it is shown that FOXM1 is significantly upregulated in early oral pre-malignant and OSCC tissues and cultured keratinocytes. Furthermore, the current study suggests that FOXM1B i

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Bulstrode, Harry John Christopher. "Dissecting the function and targets of FOXG1 in glioblastoma." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23627.

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Glioblastoma (GBM) is the most common intrinsic primary brain tumour. It is uniformly fatal, with median survival approximately 14 months. These tumours comprise a mixture of neural stem cell-like cells and more differentiated astrocytic cells. The former are thought to be responsible for tumour development and recurrence, and display self-renewal and differentiation capacity in vitro. Glioma stem cells (GSCs) are defined operationally by their capacity to initiate tumours on orthotopic transplant into immunocompromised mice. The Pollard lab has identified the neural developmental transcriptio

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Ventura, Rodolfo Françon Araújo [UNESP]. "Expressão do gene FOXE1 em culturas de osteossarcoma canino." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/86629.

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Made available in DSpace on 2014-06-11T19:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01Bitstream added on 2014-06-13T19:07:44Z : No. of bitstreams: 1 ventura_rfa_me_botfmvz.pdf: 652885 bytes, checksum: 078253297d1eddfb1fbb9da01cbf384f (MD5)<br>Universidade Estadual Paulista (UNESP)<br>O osteossarcoma (OSA) do cão ou sarcoma osteogênico é um tumor primário de comportamento biológico agressivo, prevalente em raças de médio e grande porte com idade entre sete a nove anos. O objetivo do trabalho foi aplicar um modelo experimental in vitro do osteossarcoma canino, para servir

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Priller, Markus. "Untersuchung zur Bedeutung des Transkriptionsfaktors FoxM1 beim humanen Medulloblastom." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-166850.

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Khongkow, Pasarat. "The role of FOXM1 in breast cancer chemotherapy resistance." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/42884.

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Resistance to chemotherapeutic agents is the main obstacle to the effective breast cancer management. Therefore, it is important to elucidate the molecular mechanisms of chemoresistance and develop novel therapeutic strategies in order to overcome drug resistance. In this work, I found that FOXM1 is a critical mediator of epirubicin and paclitaxel resistance in MCF-7 breast cancer cell lines. FOXM1 expression was upregulated in both epirubicin resistant MCF-7 (MCF-7 EpiR) and paclitaxel resistant MCF-7 (MCF-7 TaxR) cells compared to sensitive MCF-7 cells. Interestingly, its depletion dramatica

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Eckers, Jaimee Claire. "SEPP1 and FoxM1 regulate oxidative stress-mediated radiation response." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1449.

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Radiation is a common mode of cancer therapy that is well known to generate reactive oxygen species leading to cell damage and death. However, there are many limitations to radiation therapy including normal tissue toxicity and the presence of quiescent cancer cells that are radio-resistant. There are many factors that regulate normal and cancer cell radiation response including the cellular redox environment which includes a complex network of antioxidants. In this study, two specific objectives will be explored: (A) SEPP1 regulation of normal cell toxicity; and (B) FoxM1 regulation of quiesc

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Ventura, Rodolfo Françon Araújo. "Expressão do gene FOXE1 em culturas de osteossarcoma canino /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/86629.

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Orientador: Noeme Sousa Rocha<br>Coorientador: Adriana C. Ferrari<br>Banca: Júlio Lopes Sequeira<br>Banca: Celmira Calderon<br>Resumo: O osteossarcoma (OSA) do cão ou sarcoma osteogênico é um tumor primário de comportamento biológico agressivo, prevalente em raças de médio e grande porte com idade entre sete a nove anos. O objetivo do trabalho foi aplicar um modelo experimental in vitro do osteossarcoma canino, para servir de suporte ao estudo do gene FOXE1, gene supressor tumoral pouco investigado, entretanto de extrema importância na pesquisa do câncer pelo fato de estar envolvido com a via

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Liu, Longhua. "FoxO1 in the regulation of adipocyte autophagy and biology." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/73604.

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Obesity is a rapidly growing epidemic in the USA and worldwide. While the molecular and cellular mechanism of obesity is incompletely understood, studies have shown that excess adiposity may arise from increased adipogenesis (hyperplasia) and adipocyte size (hypertrophy) . Emerging evidence underscores autophagy as an important mediator of adipogenesis and adiposity. We are interested in the upstream regulator of adipocyte autophagy and how it impacts adipocyte biology. Given that metabolic stress activates transcription factor FoxO1 in obesity, my dissertation project is designed to depict t

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Potter, Rachael Ann. "The Impact of FoxO1 on Skeletal Muscle Protein Synthesis." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1403208596.

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Makey, Nicole Lynne. "Investigating the Role of FoxO1 in Regulating Protein Synthesis." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo156475521794138.

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Bayle, Simon. "Etude de FOXA1 dans les cellules épithéliales mammaires humaines." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22119/document.

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Les cancers du sein sont divisés en sous types définis par leur histologie, leur prolifération et l’expression du récepteur aux œstrogènes ER. Notre étude porte sur le gène FOXA1 dans le sous-type luminal caractérisé par des cellules bien différenciées, peu prolifératives et exprimant fortement les protéines FOXA1 et ER. Des études suggèrent que FOXA1 est impliqué dans le développement de la glande mammaire, dans la différenciation et la prolifération des cellules mammaires. Dans ce cadre, mon projet de thèse s’articulait autour de trois points ; développer un Knock-In au niveau du gène FOXA1,

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Dibb, Martyn. "The FOXM1-PLK1 axis in oesophageal and gastric adenocarcinoma." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-foxm1--plk1-axis-in-oesophageal-and-gastric-adenocarcinoma(a6fe1c0b-217c-40b7-88fa-d2301d6b80b7).html.

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Background: Oesophagogastric cancers generally present late in life with advanced disease and carry a poor prognosis. Few patients receive curative treatment. Polo-like Kinase 1 (PLK1) is a mitotic kinase with regulatory functions at the G2/M cell cycle phase transition. In mammalian cells, PLK1 phosphorylates and activates FOXM1, a forkhead transcription factor at the G2/M cell cycle phase transition. FOXM1 then promotes transcription of multiple gene products, including PLK1 and CCNB1, which then act individually or in complexes to further phosphorylate FOXM1 generating a positive feedback l

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Wiseman, Elizabeth Fiona. "Novel FOXM1 transcription factor target genes in oesophageal cancer." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/novel-foxm1-transcription-factor-target-genes-in-oesophageal-cancer(24278706-fa41-41b9-bf59-1902b1c4ba3d).html.

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The prognosis of oesophageal cancer remains poor, with <10% 5-year survival. Delineating the molecular pathogenesis of oesophageal cancer could inform future research into targeted therapies and may uncover novel biomarkers to aid management decisions. As a transcription factor with important roles in the control of cell cycle transcription, FOXM1 regulates cellular proliferation and chromosome stability. FOXM1 is frequently overexpressed in human cancers and this has recently been described in oesophageal adenocarcinoma (OAC) tissues. We have sought to identify novel gene targets of FOXM1 to

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Zhao, Fung. "Role of FOXM1 in ovarian cancer tumorigenesis and chemoresistance." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/28317.

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Ovarian carcinoma is the most lethal gynecological malignancy. The high relapse and mortality rates are attributable to late diagnosis and development of drug resistance. Identifying novel prognostic and therapeutic targets for ovarian carcinoma is crucial for improving patients' long-term survival rate. Forkhead box protein M1 (FOXM1), which is a widely studied member of the FOX superfamily of proteins, participates in cell proliferation and apoptosis affecting the developmental function of many organs. Recently, there has been emerging evidence supporting the biological significance of FOXM1

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Stavrou, Emmanouil. "Regulation of FOXO transcription factors by gonadotropin-releasing hormone." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5686.

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G protein-coupled receptors (GPCRs) are a large family of trans-membrane receptors that transmit signals from extracellular stimuli to target intracellular signal transduction pathways. The gonadotropin-releasing hormone receptor (GnRH-R) is a GPCR which binds the decapeptide GnRH. In the pituitary gonadotrope, GnRH stimulates gonadotropin (LH and FSH) biosynthesis and secretion to regulate reproduction. GnRH and the GnRH-Rs are also present in many extra-pituitary tissues, although their role at these sites remains largely undetermined. GnRH-Rs are known to recruit a diverse array of signalli

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McCleery, Robert Alan. "Urban fox squirrel ecology and management." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/5908.

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I studied the habitat selection, survival, and anti-predator behaviors of the fox squirrel (Siurus niger) across the urban-rural gradient in College Station, Texas. From two years of tracking the radio locations of 82 fox squirrels, my data suggested that fox squirrels in urban areas selected for use large mast bearing trees that mimicked the habitat features they prefer in non-urban areas and avoided conifer and ornamental tree species. Urban fox squirrels selected to use buildings and non-native grass during certain seasons and showed a tolerance for pavement, including it proportionally in

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