Log in

Relevant bibliographies by topics / FOXP2, alternative splicing, PTBP1 / Journal articles

To see the other types of publications on this topic, follow the link: FOXP2, alternative splicing, PTBP1.

Journal articles on the topic 'FOXP2, alternative splicing, PTBP1'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'FOXP2, alternative splicing, PTBP1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Babenko, Vladimir N., Galina T. Shishkina, Dmitriy A. Lanshakov, Ekaterina V. Sukhareva, and Nikolay N. Dygalo. "LPS Administration Impacts Glial Immune Programs by Alternative Splicing." Biomolecules 12, no. 2 (2022): 277. http://dx.doi.org/10.3390/biom12020277.

Full text

Abstract:

We performed transcriptome analysis in the hippocampus 24 h after lipopolysaccharide (LPS) administration. We observed glial-specific genes, comprised of two-thirds of all differentially expressed genes (DEGs). We found microglial DEGs that were the most numerous in LPS group. On the contrary, differential alternative splicing (DAS) analysis revealed the most numerous DAS events in astrocytes. Besides, we observed distinct major isoform switching in the Ptbp1 gene, with skipping of exon 8 in LPS group. Ptbp1 usually considered a pluripotency sustaining agent in brain embryonic development, acc

APA, Harvard, Vancouver, ISO, and other styles

2

Hinkle, Emma R., Hannah J. Wiedner, Eduardo V. Torres, et al. "Alternative splicing regulation of membrane trafficking genes during myogenesis." RNA 28, no. 4 (2022): 523–40. http://dx.doi.org/10.1261/rna.078993.121.

Full text

Abstract:

Alternative splicing transitions occur during organ development, and, in numerous diseases, splicing programs revert to fetal isoform expression. We previously found that extensive splicing changes occur during postnatal mouse heart development in genes encoding proteins involved in vesicle-mediated trafficking. However, the regulatory mechanisms of this splicing-trafficking network are unknown. Here, we found that membrane trafficking genes are alternatively spliced in a tissue-specific manner, with striated muscles exhibiting the highest levels of alternative exon inclusion. Treatment of dif

APA, Harvard, Vancouver, ISO, and other styles

3

Méreau, Agnès, Vincent Anquetil, Hubert Lerivray, et al. "A Posttranscriptional Mechanism That Controls Ptbp1 Abundance in the Xenopus Epidermis." Molecular and Cellular Biology 35, no. 4 (2014): 758–68. http://dx.doi.org/10.1128/mcb.01040-14.

Full text

Abstract:

The output of alternative splicing depends on the cooperative or antagonistic activities of several RNA-binding proteins (RBPs), like Ptbp1 and Esrp1 inXenopus. Fine-tuning of the RBP abundance is therefore of prime importance to achieve tissue- or cell-specific splicing patterns. Here, we addressed the mechanisms leading to the high expression of theptbp1gene, which encodes Ptbp1, inXenopusepidermis. Two splice isoforms ofptbp1mRNA differ by the presence of an alternative exon 11, and only the isoform including exon 11 can be translated to a full-length protein.In vivominigene assays revealed

APA, Harvard, Vancouver, ISO, and other styles

4

Zhu, Huayuan, Xiaotong Li, Xinqi Zheng, et al. "PTBP1 Regulates Alternative Splicing of Apoptotic Protein: Implications in CLL and Ibrutinib Resistance." Blood 134, Supplement_1 (2019): 1290. http://dx.doi.org/10.1182/blood-2019-126945.

Full text

Abstract:

Introduction : Ibrutinib, an oral, selective inhibitor of Bruton's tyrosine kinase (BTK), dramatically improved Progression-free survival (PFS) and Overall survival (OS) compared with immunochemotherapy in CLL both in first line and relapsed/refractory patients. However, some patients did progress on ibrutinb with dismal outcome. The underlying mechanism remains to be investigated beyond evolving of BTK and/or PLCg2 mutation, the dysfunction of apoptotic protein and mitochondrial apoptotic dependencies may be involves in ibrutinib resistance. PTBP1 (Polypyrimidine tract binding protein 1), a s

APA, Harvard, Vancouver, ISO, and other styles

5

Li, Nana, Haibo Du, Rui Ren, Yanfei Wang, and Zhigang Xu. "Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1." Neural Plasticity 2020 (July 25, 2020): 1–11. http://dx.doi.org/10.1155/2020/8898811.

Full text

Abstract:

Alternative splicing plays a pivotal role in modulating the function of eukaryotic proteins. In the inner ear, many genes undergo alternative splicing, and errors in this process lead to hearing loss. Cadherin 23 (CDH23) forms part of the so-called tip links, which are indispensable for mechanoelectrical transduction (MET) in the hair cells. Cdh23 gene contains 69 exons, and exon 68 is subjected to alternative splicing. Exon 68 of the Cdh23 gene is spliced into its mRNA only in a few cell types including hair cells. The mechanism responsible for the alternative splicing of Cdh23 exon 68 remain

APA, Harvard, Vancouver, ISO, and other styles

6

Bushra, Samira, Ying-Ni Lin, Atefeh Joudaki, et al. "Neural Isoforms of Agrin Are Generated by Reduced PTBP1−RNA Interaction Network Spanning the Neuron−Specific Splicing Regions in AGRN." International Journal of Molecular Sciences 24, no. 8 (2023): 7420. http://dx.doi.org/10.3390/ijms24087420.

Full text

Abstract:

Agrin is a heparan sulfate proteoglycan essential for the clustering of acetylcholine receptors at the neuromuscular junction. Neuron−specific isoforms of agrin are generated by alternative inclusion of three exons, called Y, Z8, and Z11 exons, although their processing mechanisms remain elusive. We found, by inspection of splicing cis−elements into the human AGRN gene, that binding sites for polypyrimidine tract binding protein 1 (PTBP1) were extensively enriched around Y and Z exons. PTBP1−silencing enhanced the coordinated inclusion of Y and Z exons in human SH−SY5Y neuronal cells, even tho

APA, Harvard, Vancouver, ISO, and other styles

7

Pina, Jeffrey M., Luis A. Hernandez, and Niroshika M. Keppetipola. "Polypyrimidine tract binding proteins PTBP1 and PTBP2 interact with distinct proteins under splicing conditions." PLOS ONE 17, no. 2 (2022): e0263287. http://dx.doi.org/10.1371/journal.pone.0263287.

Full text

Abstract:

RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturation; changes in the concentration of PTBP proteins during neuronal development direct splicing changes in many transcripts that code for proteins critical for neuronal differentiation. How the two related proteins regulate different sets of neuronal exons is unclear. The distinct splicing activities o

APA, Harvard, Vancouver, ISO, and other styles

8

Fochi, Stefania, Pamela Lorenzi, Marilisa Galasso, et al. "The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases." Genes 11, no. 4 (2020): 402. http://dx.doi.org/10.3390/genes11040402.

Full text

Abstract:

Alternative splicing is a regulatory mechanism essential for cell differentiation and tissue organization. More than 90% of human genes are regulated by alternative splicing events, which participate in cell fate determination. The general mechanisms of splicing events are well known, whereas only recently have deep-sequencing, high throughput analyses and animal models provided novel information on the network of functionally coordinated, tissue-specific, alternatively spliced exons. Heart development and cardiac tissue differentiation require thoroughly regulated splicing events. The ribonuc

APA, Harvard, Vancouver, ISO, and other styles

9

Liu, Pan, Guo-Chao He, Yu-Zhen Tan, et al. "PTBP1 is a Novel Poor Prognostic Factor for Glioma." BioMed Research International 2022 (March 8, 2022): 1–11. http://dx.doi.org/10.1155/2022/7590997.

Full text

Abstract:

Objective. Polypyrimidine tract-binding protein 1 (PTBP1) is an RNA-binding protein, which plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. However, little was known about the correlation between PTBP1 and glioma and its prognostic significance in glioma patients. Our aim was to investigate the expression, functional role, and prognostic value of PTBP1 in glioma. Methods. We explored the expression of PTBP1 protein using immunohistochemistry in 150 adult malignant glioma tissues and 20 normal brain tissues and evaluated its association with clinicopatholo

APA, Harvard, Vancouver, ISO, and other styles

10

Zhu, Wei, Bo-lun Zhou, Li-juan Rong, et al. "Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis." Journal of Zhejiang University-SCIENCE B 21, no. 2 (2020): 122–36. http://dx.doi.org/10.1631/jzus.b1900422.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Sullivan, Michael E., Jacob A. Edberg, Christopher I. Nunez, Herbert L. Axelrod, and Niroshika M. Keppetipola. "Polypyrimidine tract binding proteins PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in neuronal nuclear extract." PLOS One 20, no. 6 (2025): e0325143. https://doi.org/10.1371/journal.pone.0325143.

Full text

Abstract:

RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturation; changes in the concentration of PTB proteins during neuronal development direct splicing changes in many transcripts that code for proteins critical for neuronal differentiation. PTBP1 can compensate for the loss of PTBP2 in some developmental contexts but not others signifying the paralogs have

APA, Harvard, Vancouver, ISO, and other styles

12

Bai, Hua, and Bing Chen. "Abnormal PTBP1 Expression Sustains the Disease Progression of Multiple Myeloma." Disease Markers 2020 (June 19, 2020): 1–10. http://dx.doi.org/10.1155/2020/4013658.

Full text

Abstract:

Multiple myeloma (MM) is a hematopoietic malignancy characterized by heterogeneity, which corresponds to alternative splicing (AS) profiles and disadjust gene expression. Bioinformatics analysis of AS factors possibly related to MM progression identified the polypyrimidine tract binding protein (PTBP1) as candidate. The purpose of this study was to confirm the incidence and prognostic value of PTBP1 in MM patients. Several cohorts of 2971 patients presenting newly diagnosed and relapsed MM were enrolled. Correlations between PTBP1 expression and clinicopathological characteristics, proliferati

APA, Harvard, Vancouver, ISO, and other styles

13

Dhir, Arjun, Kevin Tur-Rodriguez, Samantha Swenson, et al. "A Novel Interaction between RUNX1 and the Splicing Factor PTBP1 Is Enriched in Leukemia Cells." Blood 142, Supplement 1 (2023): 4127. http://dx.doi.org/10.1182/blood-2023-189727.

Full text

Abstract:

RUNX1 and CBFβ form a critical hematopoietic transcription factor complex. RUNX1 is important not only for normal blood development, but also in leukemia. In the context of Inversion 16 acute myeloid leukemia (AML), RUNX1 is required for the activity of CBFβ-SMMHC (CM), the fusion oncoprotein generated by a chromosomal rearrangement and driver of this subtype of AML. The respective roles RUNX1 and CBFβ play in transcriptional regulation are well characterized but the role of other interacting partners is less well understood. To identify novel RUNX1 binding partners, we immunoprecipitated the

APA, Harvard, Vancouver, ISO, and other styles

14

Dhir, Arjun, Alexander Ethell, Kevin Tur-Rodriguez, et al. "PTBP1, an RNA Binding Protein and Splicing Regulator, Binds RUNX1 and Co-Localizes at Target Gene Promoters in Leukemia." Blood 144, Supplement 1 (2024): 2728. https://doi.org/10.1182/blood-2024-205878.

Full text

Abstract:

The transcription factor RUNX1 is a key regulator of both Acute Myeloid and Acute Lymphoid Leukemia. Work by our lab and others has shown that RUNX1 binds Histone Deacetylase 1 (HDAC1) and that the two factors co-localize at the promoters of actively transcribed RUNX1 target genes in leukemia. However, the role of HDAC1 in this complex is poorly understood. To test whether HDAC1 activity regulates the interaction of RUNX1 with other co-factors, we performed a mass spectrometry screen for RUNX1 binding partners in the presence or absence of the HDAC1 inhibitor, entinostat. From this screen, we

APA, Harvard, Vancouver, ISO, and other styles

15

Briganti, Francesca, and Zilu Wang. "Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators." International Journal of Molecular Sciences 25, no. 23 (2024): 13023. https://doi.org/10.3390/ijms252313023.

Full text

Abstract:

Alternative splicing allows a single gene to produce a variety of protein isoforms. Changes in splicing isoform usage characterize virtually every stage of the differentiation process and define the physiological differences between cardiomyocytes with different function, at different stages of development, and pathological function. Recent identification of cardiac splicing factors provided insights into the mechanisms underlying alternative splicing and revealed how these splicing factors impact functional properties of the heart. Alterations of the splicing of sarcomeric genes, cell signali

APA, Harvard, Vancouver, ISO, and other styles

16

Sasabe, Toshikazu, Eugene Futai, and Shoichi Ishiura. "PTBP1 regulates the alternative splicing of dopamine receptor D2 (DRD2)." Neuroscience Research 65 (January 2009): S90. http://dx.doi.org/10.1016/j.neures.2009.09.369.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Lei, Jianzhen, Xiaoxin Liu, Miaomiao Song, et al. "Aberrant Exon 8/8a Splicing by Downregulated PTBP (Polypyrimidine Tract-Binding Protein) 1 Increases Ca V 1.2 Dihydropyridine Resistance to Attenuate Vasodilation." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 10 (2020): 2440–53. http://dx.doi.org/10.1161/atvbaha.120.315010.

Full text

Abstract:

Objective: Calcium channel blockers, such as dihydropyridines, are commonly used to inhibit enhanced activity of vascular Ca V 1.2 channels in hypertension. However, patients who are insensitive to such treatments develop calcium channel blocker-resistant hypertension. The function of Ca V 1.2 channel is diversified by alternative splicing, and the splicing factor PTBP (polypyrimidine tract-binding protein) 1 influences the utilization of mutually exclusive exon 8/8a of the Ca V 1.2 channel during neuronal development. Nevertheless, whether and how PTBP1 makes a role in the calcium channel blo

APA, Harvard, Vancouver, ISO, and other styles

18

Lorenzi, P., A. Sangalli, S. Fochi, et al. "RNA-binding proteins RBM20 and PTBP1 regulate the alternative splicing of FHOD3." International Journal of Biochemistry & Cell Biology 106 (January 2019): 74–83. http://dx.doi.org/10.1016/j.biocel.2018.11.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Zhu, H., X. Li, X. Zheng, et al. "PTBP1 REGULATES ALTERNATIVE SPLICING OF APOPTOTIC PROTEIN: IMPLICATIONS IN CLL AND IBRUTINIB RESISTANCE." Hematological Oncology 37 (June 2019): 373–74. http://dx.doi.org/10.1002/hon.41_2631.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Fuentes-Fayos, Antonio C., Mari C. Vázquez-Borrego, Juan M. Jiménez-Vacas, et al. "Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3." Brain 143, no. 11 (2020): 3273–93. http://dx.doi.org/10.1093/brain/awaa273.

Full text

Abstract:

Abstract Glioblastomas remain the deadliest brain tumour, with a dismal ∼12–16-month survival from diagnosis. Therefore, identification of new diagnostic, prognostic and therapeutic tools to tackle glioblastomas is urgently needed. Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in tumours, leading to oncogenic splicing events associated with tumour progression and aggressiveness. Here, we identify for the first time a profound dysregulation in the expression of relevant spliceosome components and splicing factors (at mRNA and p

APA, Harvard, Vancouver, ISO, and other styles

21

Vernes, Sonja C., and Simon E. Fisher. "Unravelling neurogenetic networks implicated in developmental language disorders." Biochemical Society Transactions 37, no. 6 (2009): 1263–69. http://dx.doi.org/10.1042/bst0371263.

Full text

Abstract:

Childhood syndromes disturbing language development are common and display high degrees of heritability. In most cases, the underlying genetic architecture is likely to be complex, involving multiple chromosomal loci and substantial heterogeneity, which makes it difficult to track down the crucial genomic risk factors. Investigation of rare Mendelian phenotypes offers a complementary route for unravelling key neurogenetic pathways. The value of this approach is illustrated by the discovery that heterozygous FOXP2 (where FOX is forkhead box) mutations cause an unusual monogenic disorder, charac

APA, Harvard, Vancouver, ISO, and other styles

22

Kim, Jeongjin J., Mohammed E. Sayed, Alexander Ahn, Aaron L. Slusher, Jeffrey Y. Ying, and Andrew T. Ludlow. "Dynamics of TERT regulation via alternative splicing in stem cells and cancer cells." PLOS ONE 18, no. 8 (2023): e0289327. http://dx.doi.org/10.1371/journal.pone.0289327.

Full text

Abstract:

Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer cells and somatic cells, stem cells express TERT and rely on telomerase activity for physiological replacement of cells. Therefore, identifying differences in TERT regulation between stem cells and cancer cells is essential for developing telomerase inhibition-based cancer therapies that reduce damage to stem cells. In this study, we measured TERT splice variant e

APA, Harvard, Vancouver, ISO, and other styles

23

Wang, Zhi-na, Dan Liu, Bin Yin, et al. "High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin." Oncotarget 8, no. 22 (2017): 36185–202. http://dx.doi.org/10.18632/oncotarget.15873.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Calabretta, S., P. Bielli, I. Passacantilli, et al. "Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells." Oncogene 35, no. 16 (2015): 2031–39. http://dx.doi.org/10.1038/onc.2015.270.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Izaguirre, Daisy I., Wen Zhu, Tao Hai, Hannah C. Cheung, Ralf Krahe, and Gilbert J. Cote. "PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis." Molecular Carcinogenesis 51, no. 11 (2011): 895–906. http://dx.doi.org/10.1002/mc.20859.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Williams, Allison Lesher, Vedbar Khadka, Mingxin Tang, et al. "HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction." Physiological Genomics 50, no. 7 (2018): 479–94. http://dx.doi.org/10.1152/physiolgenomics.00130.2017.

Full text

Abstract:

Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription factor that rapidly responds to loss of oxygen through alteration of metabolism and angiogenesis. The goal of this study was to investigate the transcriptional response after myocardial infarction (MI) and to identify novel, hypoxia-driven changes, including alternative splicing. After ligation of the left anterior descending artery in mice, we obse

APA, Harvard, Vancouver, ISO, and other styles

27

Li, Yang I., Luis Sanchez-Pulido, Wilfried Haerty, and Chris P. Ponting. "RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts." Genome Research 25, no. 1 (2014): 1–13. http://dx.doi.org/10.1101/gr.181990.114.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Futamura, Manabu, Yoshihisa Tokumaru, Akira Nakakami, Mai Okawa, Ryutaro Mori, and Nobuhisa Matsuhashi. "Abstract P5-06-14: PTBP1 is associated with tumor proliferation as an oncogene that regulates breast cancer metabolism." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–06–14—P5–06–14. https://doi.org/10.1158/1557-3265.sabcs24-p5-06-14.

Full text

Abstract:

Abstract Background: We previously studied cancer cell metabolism. A critical difference exists between cancer and normal cells in terms of their energy-producing mechanisms. Polypyrimidine tract-binding protein 1 (PTBP1), which is predominantly expressed in tumor cells, plays a central role in supplying energy to cancer cells. Alternative splicing of pyruvate kinase muscle (PKM) by PTBP1 results in the formation of two isoforms: PKM1 and PKM2. Normal cells are PKM1-dominant and receive energy mainly from the TCA cycle through oxidative phosphorylation. In contrast, cancer cells are PKM2-domin

APA, Harvard, Vancouver, ISO, and other styles

29

Vadlamudi, Yellamandayya, Debasish K. Dey, and Sun C. Kang. "Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT." Current Cancer Drug Targets 20, no. 9 (2020): 654–65. http://dx.doi.org/10.2174/1568009620666200621153831.

Full text

Abstract:

RNA binding proteins (RBPs) associate with nascent and mature RNAs to perform biological functions such as alternative splicing and RNA stability. Having unique RNA recognition binding motifs, RBPs form complexes with RNA in a sequence- and structure-based manner. Aberrant expressions of several RBPs have been identified in tumorigenesis and cancer progression. These uncontrolled RBPs affect several mechanisms, including cell proliferation, tumor growth, invasion, metastasis and chemoresistance. Epithelial splicing regulatory protein 1 (ESRP1) is a member of the hnRNP family of proteins that p

APA, Harvard, Vancouver, ISO, and other styles

30

Iwamori, Naoki, Kaoru Tominaga, Tetsuya Sato, et al. "MRG15 is required for pre-mRNA splicing and spermatogenesis." Proceedings of the National Academy of Sciences 113, no. 37 (2016): E5408—E5415. http://dx.doi.org/10.1073/pnas.1611995113.

Full text

Abstract:

Splicing can be epigenetically regulated and involved in cellular differentiation in somatic cells, but the interplay of epigenetic factors and the splicing machinery during spermatogenesis remains unclear. To study these interactions in vivo, we generated a germline deletion of MORF-related gene on chromosome 15 (MRG15), a multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells. Cond

APA, Harvard, Vancouver, ISO, and other styles

31

Fuentes-Fayos, A. C., M. C. Vázquez-Borrego, J. M. Jiménez-Vacas, et al. "P11.17 Splicing dysregulation drives glioblastoma malignancy: SRSF3 as a potential therapeutic target to impair glioblastoma progression." Neuro-Oncology 21, Supplement_3 (2019): iii46. http://dx.doi.org/10.1093/neuonc/noz126.163.

Full text

Abstract:

Abstract Glioblastomas (GBMs) remain the deadliest human brain tumors, with poor prognosis despite years of research. Currently, standard therapeutic strategies to treat GBM are not efficient and common survival from diagnosis is ~12–16 months. Thus, identification of new diagnostic/prognostic/therapeutic tools to tackle GBMs is crucial. Emerging evidence indicates that the cellular machinery controlling alternative splicing is altered in tumor pathologies, leading to oncogenic splicing events linked to tumor progression. Accordingly, we aimed to determine the expression pattern of the spliceo

APA, Harvard, Vancouver, ISO, and other styles

32

Campagne, Sébastien, Tebbe de Vries, Florian Malard, et al. "An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands." Nucleic Acids Research 49, no. 11 (2021): e63-e63. http://dx.doi.org/10.1093/nar/gkab135.

Full text

Abstract:

Abstract U1 small nuclear ribonucleoparticle (U1 snRNP) plays a central role during RNA processing. Previous structures of U1 snRNP revealed how the ribonucleoparticle is organized and recognizes the pre-mRNA substrate at the exon–intron junction. As with many other ribonucleoparticles involved in RNA metabolism, U1 snRNP contains extensions made of low complexity sequences. Here, we developed a protocol to reconstitute U1 snRNP in vitro using mostly full-length components in order to perform liquid-state NMR spectroscopy. The accuracy of the reconstitution was validated by probing the shape a

APA, Harvard, Vancouver, ISO, and other styles

33

Yamazaki, Takashi, Lizhi Liu, and James L. Manley. "TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1." RNA 25, no. 11 (2019): 1497–508. http://dx.doi.org/10.1261/rna.072298.119.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Georgilis, Athena, Sabrina Klotz, Christopher J. Hanley, et al. "PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells." Cancer Cell 34, no. 1 (2018): 85–102. http://dx.doi.org/10.1016/j.ccell.2018.06.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Babenko, Vladimir, Olga Redina, Dmitry Smagin, Irina Kovalenko, Anna Galyamina, and Natalia Kudryavtseva. "Elucidation of the Landscape of Alternatively Spliced Genes and Features in the Dorsal Striatum of Aggressive/Aggression-Deprived Mice in the Model of Chronic Social Conflicts." Genes 14, no. 3 (2023): 599. http://dx.doi.org/10.3390/genes14030599.

Full text

Abstract:

Both aggressive and aggression-deprived (AD) individuals represent pathological cases extensively studied in psychiatry and substance abuse disciplines. We employed the animal model of chronic social conflicts curated in our laboratory for over 30 years. In the study, we pursued the task of evaluation of the key events in the dorsal striatum transcriptomes of aggression-experienced mice and AD species, as compared with the controls, using RNA-seq profiling. We evaluated the alternative splicing-mediated transcriptome dynamics based on the RNA-seq data. We confined our attention to the exon ski

APA, Harvard, Vancouver, ISO, and other styles

36

Tahmasebi, Soroush, Seyed Mehdi Jafarnejad, Ingrid S. Tam, et al. "Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2." Proceedings of the National Academy of Sciences 113, no. 44 (2016): 12360–67. http://dx.doi.org/10.1073/pnas.1615540113.

Full text

Abstract:

Translational control of gene expression plays a key role during the early phases of embryonic development. Here we describe a transcriptional regulator of mouse embryonic stem cells (mESCs), Yin-yang 2 (YY2), that is controlled by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs). YY2 plays a critical role in regulating mESC functions through control of key pluripotency factors, including Octamer-binding protein 4 (Oct4) and Estrogen-related receptor-β (Esrrb). Importantly, overexpression of YY2 directs the differentiation of mESCs into cardiovascular linea

APA, Harvard, Vancouver, ISO, and other styles

37

Mironov, Aleksei, Stepan Denisov, Alexander Gress, Olga V. Kalinina, and Dmitri D. Pervouchine. "An extended catalogue of tandem alternative splice sites in human tissue transcriptomes." PLOS Computational Biology 17, no. 4 (2021): e1008329. http://dx.doi.org/10.1371/journal.pcbi.1008329.

Full text

Abstract:

Tandem alternative splice sites (TASS) is a special class of alternative splicing events that are characterized by a close tandem arrangement of splice sites. Most TASS lack functional characterization and are believed to arise from splicing noise. Based on the RNA-seq data from the Genotype Tissue Expression project, we present an extended catalogue of TASS in healthy human tissues and analyze their tissue-specific expression. The expression of TASS is usually dominated by one major splice site (maSS), while the expression of minor splice sites (miSS) is at least an order of magnitude lower.

APA, Harvard, Vancouver, ISO, and other styles

38

SENOO, Manami, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, et al. "RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3." Journal of Reproduction and Development 66, no. 5 (2020): 459–67. http://dx.doi.org/10.1262/jrd.2020-060.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Venkataramany, Akila S., Safiya Khurshid, Anthony R. Miller, et al. "Abstract 3560: Understanding alternative splicing in Ewing sarcoma progression and metastasis to inform novel therapy development." Cancer Research 83, no. 7_Supplement (2023): 3560. http://dx.doi.org/10.1158/1538-7445.am2023-3560.

Full text

Abstract:

Abstract Introduction: Ewing sarcoma (ES) is the second most common pediatric bone cancer, and patients with metastases have five-year survival rates of &lt;30%. Both local and metastatic ES tumors are characterized by the EWS-FLI1 chromosomal translocation, resulting in an aberrant transcription factor that increases ES cell proliferation and metastasis. EWS-FLI1 activity and ES transformation are reliant upon increased IGF-1 signaling, so initial therapies have centered on IGF-1R inhibition. However, compensatory upregulation of insulin receptor A (IR-A), an oncogenic spliced isoform of

APA, Harvard, Vancouver, ISO, and other styles

40

Bielli, Pamela, Matteo Bordi, Valentina Di Biasio, and Claudio Sette. "Regulation of BCL-X splicing reveals a role for the polypyrimidine tract binding protein (PTBP1/hnRNP I) in alternative 5′ splice site selection." Nucleic Acids Research 42, no. 19 (2014): 12070–81. http://dx.doi.org/10.1093/nar/gku922.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Qiao, Lu, Ning Xie, Yuru Bai, et al. "Identification of Upregulated HNRNPs Associated with Poor Prognosis in Pancreatic Cancer." BioMed Research International 2019 (July 4, 2019): 1–11. http://dx.doi.org/10.1155/2019/5134050.

Full text

Abstract:

Heterogeneous nuclear ribonucleoproteins (HNRNPs) are reported to play a crucial role in the pathogenic process of multiple malignancies. However, the expression patterns and prognostic values of HNRNPs in pancreatic cancer (PC) are lacking. In this study, several public databases were explored to identify the commonly upregulated HNRNPs in PC. The clinical significance of HNRNPL (heterogeneous nuclear ribonucleoproteins L) in PC was analyzed. We further performed a series of experiments to elucidate the biological functions of HNRNPL. Bioinformatics analysis including pathway enrichment and i

APA, Harvard, Vancouver, ISO, and other styles

42

Hershberger, Courtney, James Hiznay, Rosemary Dietrich, et al. "LUC7L2 Is a Novel RNA-Splicing Regulatory Factor Mutated in Myelodysplastic Syndromes." Blood 132, Supplement 1 (2018): 3073. http://dx.doi.org/10.1182/blood-2018-99-112838.

Full text

Abstract:

Abstract Myelodysplastic syndromes (MDS) are unique among cancers because of the frequent occurrence of somatic mutations impacting spliceosome machinery. At least 65% of MDS patients harbor a mutation in one of several splicing factors including U2AF1, SF3B1 and SRSF2. Whole exome sequencing of MDS bone marrow uncovered somatic frameshift mutations in LUC7L2, the mammalian ortholog of a yeast splicing factor. LUC7L2 is located in the most commonly deleted region of chromosome 7. Deletions and frameshifts lead to haploinsufficient expression and therefore it can be approximated that a combined

APA, Harvard, Vancouver, ISO, and other styles

43

Wu, Haili, Jin’e Du, Chenglu Li, Hanqing Li, Huiqin Guo, and Zhuoyu Li. "Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis." International Journal of Molecular Sciences 23, no. 7 (2022): 3544. http://dx.doi.org/10.3390/ijms23073544.

Full text

Abstract:

Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in the cure of colon cancer. Therefore, there is an urgent need to explore a safe and effective multidrug resistance reversal agent for colorectal cancer, which would be of great significance for improving clinical efficacy. The dietary flavonoid kaempferol plays a key role in the progression of colorectal cancer and 5-Fu resistance. However, the molecular mechanism of kaempferol in reversing 5-Fu resistance in human colorectal cancer cells is still unclear. We found that kaempferol could reverse the drug r

APA, Harvard, Vancouver, ISO, and other styles

44

Patiño-Trives, A. M., C. Perez-Sanchez, A. Ibañez-Costa, et al. "OP0038 SPLICEOSOME ALTERATIONS IN LEUCOCYTES FROM APS, SLE AND SLE+APS PATIENTS ARE CLOSELY RELATED TO THEIR MAIN CLINICAL FEATURES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 20.2–20. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2485.

Full text

Abstract:

Background:To date, although multiple molecular approaches have illustrated the various aspects of Primary Antiphospholipid Syndrome (APS), systemic lupus erythematosus (SLE) and antiphospholipid syndrome plus lupus (APS plus SLE), no study has so far fully characterized the potential role of posttranscriptional regulatory mechanisms such as the alternative splicing.Objectives:To identify shared and differential changes in the splicing machinery of immune cells from APS, SLE and APS plus SLE patients, and their involvement in the activity and clinical profile of these autoimmune disorders.Meth

APA, Harvard, Vancouver, ISO, and other styles

45

Scholl, Amanda, Alexander Muselman, and Dong-Er Zhang. "An Intronic Suppressor Element Regulates RUNX1 Alternative Polyadenylation." Blood 126, no. 23 (2015): 3578. http://dx.doi.org/10.1182/blood.v126.23.3578.3578.

Full text

Abstract:

Abstract Polyadenylation is a post-transcriptional modification where the 3' end of an mRNA is cleaved and 250-300 adenines are added. It is predicted that 70-75% of human genes have more than one polyadenylation sequence (PAS) and are subject to alternative polyadenylation (APA). APA events affect the coding sequence of a gene when a proximal PAS is located within an intron, constitutive exon, or alternative exon. Gene expression is also affected if there are multiple PAS within the distal 3' untranslated region (UTR); proximal PAS usage shortens the 3'UTR, which can remove cis-regulatory reg

APA, Harvard, Vancouver, ISO, and other styles

46

Liu, Hongyu, Ran Duan, Xiaoyu He, et al. "Endothelial deletion of PTBP1 disrupts ventricular chamber development." Nature Communications 14, no. 1 (2023). http://dx.doi.org/10.1038/s41467-023-37409-9.

Full text

Abstract:

AbstractThe growth and maturation of the ventricular chamber require spatiotemporally precise synergy between diverse cell types. Alternative splicing deeply affects the processes. However, the functional properties of alternative splicing in cardiac development are largely unknown. Our study reveals that an alternative splicing factor polypyrimidine tract-binding protein 1 (PTBP1) plays a key role in ventricular chamber morphogenesis. During heart development, PTBP1 colocalizes with endothelial cells but is almost undetectable in cardiomyocytes. The endothelial-specific knockout of Ptbp1, in

APA, Harvard, Vancouver, ISO, and other styles

47

Ontiveros, Robert Jordan, Justin Doan, Eric Adams, A. L. Hernandez, Douglas L. Black, and Niroshika M. Keppetipola. "Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.598.7.

Full text

Abstract:

In higher eukaryotes, alternative splicing of a single gene transcript into multiple final spliced mRNA contributes significantly towards the diversity of cellular proteins. The process of alternative splicing is regulated in part by RNA binding proteins that bind to RNA adjacent to regulated exons and influence the assembly of a functional spliceosome at adjacent splice sites. Aberrant alternative splicing has been identified in many diseases such as Alzheimer's disease, muscular dystrophy, and ovarian cancer, underscoring the importance of alternative splicing. Consequently, detailed mechani

APA, Harvard, Vancouver, ISO, and other styles

48

Ricketts, Shea N., Shufen Chen, and Li Qian. "Abstract P2103: Cardiac Fibroblast-specific Role Of PTBP1 In Maintaining Heart Function." Circulation Research 133, Suppl_1 (2023). http://dx.doi.org/10.1161/res.133.suppl_1.p2103.

Full text

Abstract:

Cardiac fibroblasts (CFs) are the primary nonmyocyte in the heart that maintain cardiac homeostasis by regulating myocardial function and cardiac remodeling. CFs secrete an extracellular matrix to stabilize the myocardial wall while maintaining the heart’s mechanical integrity during development and pathogenesis. Developmental and pathogenic transitions are directed through CFs by transcriptional and post-transcriptional modifications, such as alternative splicing. Alternative splicing is a central element in post-transcriptional gene regulation and proteomic diversity. Impaired and aberrant s

APA, Harvard, Vancouver, ISO, and other styles

49

Miao, Hui, Fan Wu, Yu Li, et al. "MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF." Science Advances 8, no. 51 (2022). http://dx.doi.org/10.1126/sciadv.abq7289.

Full text

Abstract:

Understanding how long noncoding RNAs (lncRNAs) cooperate with splicing factors (SFs) in alternative splicing (AS) control is fundamental to human biology and disease. We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 (PTBP1) and PTB-associated SF (PSF). MALAT1 stabilizes the interaction between PTBP1 and PSF, thereby forming a functional module that affects a network of AS events. The MALAT1-stabilized PTBP1/PSF interaction occurs in multiple cellular contexts;

APA, Harvard, Vancouver, ISO, and other styles

50

Ontiveros, Robert J., Justin Doan, Eric S. Adams, A. L. Hernandez, Douglas L. Black, and Niroshika M. Keppetipola. "Identification and Characterization of a Minimal Functional Splicing Regulatory Protein." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.590.8.

Full text

Abstract:

In higher eukaryotes, alternative splicing of a single gene transcript into multiple final mRNA isoforms contributes significantly towards the diversity of cellular protein composition. The process of alternative splicing is regulated in part by RNA binding proteins which bind within and adjacent to regulated exons, influencing the location and assembly of a functional spliceosome. Splice variants have been identified in many neurodegenerative diseases and cancers, underscoring the importance of alternative splicing. Detailed mechanistic and atomic understanding of how splice variants are gene

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!