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Journal articles on the topic 'Foxp3[Forkhead box protein 3]'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Utomo, Bambang Suprayogi Resi, Mochammad Hatta, Sutji Pratiwi, Muhammad Nasrum Massi, Lina Marlina, and Erica Gilda Minawati Simanjuntak. "Analysis of Forkhead Box Protein-3 (Foxp3) in Allergic Rhinitis Patients." International Journal of Otolaryngology and Head & Neck Surgery 07, no. 04 (2018): 228–36. http://dx.doi.org/10.4236/ijohns.2018.74024.

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2

Liu, X. Y., L. Z. Xu, X. Q. Luo, et al. "Forkhead box protein-3 (Foxp3)-producing dendritic cells suppress allergic response." Allergy 72, no. 6 (2017): 908–17. http://dx.doi.org/10.1111/all.13088.

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3

Yong, Fangfang, Hemei Wang, Chao Li, and Huiqun Jia. "Sevoflurane represses the migration and invasion of gastric cancer cells by regulating forkhead box protein 3." Journal of International Medical Research 49, no. 4 (2021): 030006052110059. http://dx.doi.org/10.1177/03000605211005936.

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Objective Previous studies suggested that sevoflurane exerts anti-proliferative, anti-migratory, and anti-invasive effects on cancer cells. To determine the role of sevoflurane on gastric cancer (GC) progression, we evaluated its effects on the proliferation, migration, and invasion of SGC7901, AGS, and MGC803 GC cells. Methods GC cells were exposed to different concentrations of sevoflurane (1.7, 3.4, or 5.1% v/v). Cell viability, migration, and invasion were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assays. Immunohistochemical staining and imm

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Chinn, I. K., J. D. Milner, P. Scheinberg, D. C. Douek, and M. L. Markert. "Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+and FoxP3−T cells in complete DiGeorge anomaly." Clinical & Experimental Immunology 173, no. 1 (2013): 140–49. http://dx.doi.org/10.1111/cei.12088.

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Lin, Zewei, Xu Liu, Xiaoping Liu, and Jikui Liu. "DNA hypermethylation of the promoter attenuates forkhead box protein 3 (FOXP3) expression in hepatocellular carcinoma cells." Translational Cancer Research 8, no. 5 (2019): 2024–31. http://dx.doi.org/10.21037/tcr.2019.09.09.

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6

Wang, Meiqin, Ivana Yang, Elizabeth J. Davidson, et al. "Forkhead Box Protein 3 (FoxP3) Demethylation Is Associated with Tolerance Induction in Peanut-Induced Intestinal Allergy." Journal of Allergy and Clinical Immunology 137, no. 2 (2016): AB176. http://dx.doi.org/10.1016/j.jaci.2015.12.712.

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Brunst, Kelly J., Yuet-Kin Leung, Patrick H. Ryan, et al. "Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma." Journal of Allergy and Clinical Immunology 131, no. 2 (2013): 592–94. http://dx.doi.org/10.1016/j.jaci.2012.10.042.

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8

Passerini, Laura, Sven Olek, Sara Di Nunzio, et al. "Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability." Journal of Allergy and Clinical Immunology 128, no. 6 (2011): 1376–79. http://dx.doi.org/10.1016/j.jaci.2011.09.010.

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9

Lozano, Teresa, Noelia Casares, Celia Martil-Otal, et al. "Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor." Biomedicines 9, no. 2 (2021): 197. http://dx.doi.org/10.3390/biomedicines9020197.

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(1) Background: The ability of cancer cells to evade the immune system is due in part to their capacity to induce and recruit T regulatory cells (Tregs) to the tumor microenvironment. Strategies proposed to improve antitumor immunity by depleting Tregs generally lack specificity and raise the possibility of autoimmunity. Therefore, we propose to control Tregs by their functional inactivation rather than depletion. Tregs are characterized by the expression of the Forkhead box protein 3 (FOXP3) transcription factor, which is considered their “master regulator”. Its interaction with DNA is assist

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North, Michelle, Sarah Mah, Lisa Steacy, Jeffrey Brook, Michael Kobor, and Anne K. Ellis. "Effects of Maternal Allergy On Umbilical Cord Blood Regulatory T Cell Forkhead Box Protein 3 (FOXP3) DNA Methylation." Journal of Allergy and Clinical Immunology 131, no. 2 (2013): AB53. http://dx.doi.org/10.1016/j.jaci.2012.12.872.

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11

Abdukassimova, Meruyert, Perizat Kanabekova, Zhansaya Bauyrzhanova, et al. "Association of Human forkhead box protein 3 (FOXP3) gene polymorphisms with idiopathic recurrent pregnancy loss among Kazakhstani women." Gene 801 (October 2021): 145835. http://dx.doi.org/10.1016/j.gene.2021.145835.

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12

Scazzone, Concetta, Luisa Agnello, Bruna Lo Sasso, et al. "FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis." Brain Sciences 11, no. 4 (2021): 415. http://dx.doi.org/10.3390/brainsci11040415.

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Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3 gene polymorphisms have been associated with the susceptibility to autoimmune diseases. The expression of Foxp3 in Tregs is regulated by the transcription factor GATA binding-protein 3 (GATA3) and vitamin D3. The aim of this retrospective case-control study was to investigate the potential association between FOXP3 and GATA3 genetic variants,

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13

Duztas, Demet Teker, Lina Al-Shadfan, Hakan Ozturk, et al. "New Findings of Immunodysregulation, Polyendocrinopathy, and Enteropathy X-linked Syndrome (IPEX); Granulomas in Lung and Duodenum." Pediatric and Developmental Pathology 24, no. 3 (2021): 252–57. http://dx.doi.org/10.1177/1093526621998868.

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Immune dysregulation, polyendocrinopathy and enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by loss-of-function mutations in the gene forkhead box protein 3 (FOXP3). IPEX patients frequently show chronic diarrhea (enteropathy) associated with villous atrophies in the small intestine. Our case is different from this classical information in the literature, since he presented with neonatal onset inflammatory bowel disease within the first months of life accompanied by deep ulcers throughout colonic mucosa. Moreover, he developed chronic lung disease during follow-up and histopat

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14

Lahl, Katharina, Christoph Loddenkemper, Cathy Drouin, et al. "Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease." Journal of Experimental Medicine 204, no. 1 (2007): 57–63. http://dx.doi.org/10.1084/jem.20061852.

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The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central control element in the development and function of regulatory T cells (T reg cells), which are necessary for the maintenance of self-tolerance. However, it is unclear whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis and its human correlate, the IPEX syndrome.

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Cui, Can, Shunshun Han, Huadong Yin, et al. "FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens." BioMed Research International 2019 (July 11, 2019): 1–9. http://dx.doi.org/10.1155/2019/6902906.

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FOXO3, which encodes the transcription factor forkhead box O-3 (FoxO3), is a member of the FOXO subfamily of the forkhead box (FOX) family. FOXO3 can be negatively regulated by its phosphorylation by the PI3K/Akt signaling pathway and ultimately drives apoptosis when activated. In mammalian ovaries, the FOXO3 protein regulates atresia and follicle growth by promoting apoptosis of ovarian granulosa cells. Nonetheless, the specific effects of the FOXO3 protein on granulosa apoptosis of avian ovaries have not been elucidated. Therefore, we studied FOXO3 expression in follicles with different orga

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Zhu, Yingming, Minghuan Li, and Jinming Yu. "Association of CD8+/FOXP3+ ratio and PD-L1 expression with survival in pT3N0M0 stage esophageal squamous cell cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15517-e15517. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15517.

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e15517 Background: Data describing relationships between the tumor immune microenvironment and patient outcome are limited for esophageal squamous cell cancer (ESCC). Methods: The present study investigated the prognostic values of programmed death-ligand 1 (PD-L1) expression and CD8+ or forkhead box protein 3+ (FOXP3+) tumor-infiltrating lymphocytes (TILs) in 133 pathological T3N0M0 stage ESCC patients who underwent radical resection without neoadjuvant or adjuvant therapy. CD8+ and FOXP3+ TIL densities as well as PD-L1 levels in tumor cells and lymphocytes, were assessed through immunohistoc

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Goodwin, M., E. Lee, U. Lakshmanan, et al. "CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells." Science Advances 6, no. 19 (2020): eaaz0571. http://dx.doi.org/10.1126/sciadv.aaz0571.

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The prototypical genetic autoimmune disease is immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, a severe pediatric disease with limited treatment options. IPEX syndrome is caused by mutations in the forkhead box protein 3 (FOXP3) gene, which plays a critical role in immune regulation. As a monogenic disease, IPEX is an ideal candidate for a therapeutic approach in which autologous hematopoietic stem and progenitor (HSPC) cells or T cells are gene edited ex vivo and reinfused. Here, we describe a CRISPR-based gene correction permitting regulated expression of FOXP3

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18

Wang, Y. Y., Q. Wang, X. H. Sun, et al. "DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis." British Journal of Dermatology 171, no. 1 (2014): 39–47. http://dx.doi.org/10.1111/bjd.12913.

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Garcia-Rodriguez, Sonia, Jose-Luis Callejas-Rubio, Norberto Ortego-Centeno, et al. "Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients." Mediators of Inflammation 2012 (2012): 1–14. http://dx.doi.org/10.1155/2012/495934.

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Kinases have been implicated in the immunopathological mechanisms of Systemic Lupus Erythematosus (SLE). v-akt murine-thymoma viral-oncogene-homolog 1 (AKT1) and mitogen-activated-protein-kinase 1 (MAPK1) gene expressions in peripheral mononuclear cells from thirteen SLE patients with inactive or mild disease were evaluated using quantitative real-time reverse-transcription polymerase-chain-reaction and analyzed whether there was any correlation with T-helper (Th) transcription factors (TF) gene expression, cytokines, and S100A8/S100A9-(Calprotectin). Age- and gender-matched thirteen healthy c

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Syed, Aleena, Marco A. Garcia, Shu-Chen Lyu, et al. "Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)." Journal of Allergy and Clinical Immunology 133, no. 2 (2014): 500–510. http://dx.doi.org/10.1016/j.jaci.2013.12.1037.

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21

Khalaf, Mustafa Saleam, Abbas Toma Joda, and Estabraq Abdulrasool Kwaeri. "Role of Forkhead box O 3 (FoxO3) Protein in Iraqi Patients with Knee Osteoarthritis (KOA)." Indian Journal of Forensic Medicine & Toxicology 13, no. 4 (2019): 648. http://dx.doi.org/10.5958/0973-9130.2019.00365.7.

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22

Ma, L., P. Zhao, Z. Jiang, Y. Shan, and Y. Jiang. "Imbalance of different types of CD4+forkhead box protein 3 (FoxP3)+T cells in patients with new-onset systemic lupus erythematosus." Clinical & Experimental Immunology 174, no. 3 (2013): 345–55. http://dx.doi.org/10.1111/cei.12189.

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23

Ma, Yemei, Ying Ye, Yining Liu, et al. "DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes." Toxicology Research 9, no. 4 (2020): 519–29. http://dx.doi.org/10.1093/toxres/tfaa056.

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Abstract Growing evidence indicates that arsenic can cause long-lasting and irreversible damage to the function of the human immune system. It is known that forkhead box protein 3(Foxp3), which is specifically expressed in regulatory T cells (Tregs), plays a decisive role in immunoregulation and is regulated by DNA methylation. While evidence suggests that epigenetic regulated Foxp3 is involved in the immune disorders caused by arsenic exposure, the specific mechanism remains unclear. In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed

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Holub, Michal, Alžběta Stráníková, Ondřej Beran, et al. "Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells." Canadian Journal of Infectious Diseases and Medical Microbiology 2021 (March 12, 2021): 1–6. http://dx.doi.org/10.1155/2021/6689834.

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Background. Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response. Objective. The aim of the study was to characterize functional alterations in CD4+ T cell subsets and myeloid-derived suppressor cells (MDSCs) during chronic hepatitis C virus (HCV) infection. Methodology. The expression levels of the lineage-defining transcriptional factors (TFs) T-bet, Gata3, Rorγt, and Foxp3 in circulating CD4+ T cells and percentages of MDSCs in peripheral blood were evaluated in 33 patients with CHC, 31 persons, who had spontaneously cleared the HCV infection, and 30 healthy su

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Golding, A., S. Darko, W. H. Wylie, D. C. Douek та E. M. Shevach. "Deep sequencing of the TCR-β repertoire of human forkhead box protein 3 (FoxP3)+ and FoxP3- T cells suggests that they are completely distinct and non-overlapping". Clinical & Experimental Immunology 188, № 1 (2017): 12–21. http://dx.doi.org/10.1111/cei.12904.

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26

Chen, Szu-Ying, Wan-Tseng Hsu, Yi-Lien Chen, Chien-Hui Chien, and Bor-Luen Chiang. "Lymphocyte-activation gene 3 + (LAG3 + ) forkhead box protein 3 − (FOXP3 − ) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis." Journal of Autoimmunity 68 (April 2016): 75–85. http://dx.doi.org/10.1016/j.jaut.2016.02.002.

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Kanda, Naoko, Toshihiko Hoashi, and Hidehisa Saeki. "The Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches." Journal of Clinical Medicine 10, no. 17 (2021): 3880. http://dx.doi.org/10.3390/jcm10173880.

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Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin (IL)-23/IL-17 axis. Patients with psoriasis manifest functional defects in CD4+CD25+ forkhead box protein 3 (Foxp3)+ regulatory T cells (Tregs), which suppress the excess immune response and mediate homeostasis. Defects in Tregs contribute to the pathogenesis of psoriasis and may attribute to enhanced inhibition and/or impaired stimulation of Tregs. IL-23 induces the conversion of Tregs into type 17 helper T (Th17) cells. IL-17A reduces transforming growth factor (TGF)-β1 productio

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Gamboa, Jonifel C., Ryan Bismark C. Padiernos, Mary Rose D. Uy, Elfren F. Celestino, and Claro N. Mingala. "Comparative molecular characterization of Forkhead box protein 3 (FoxP3) gene of swamp-type (Bubalus carabanensis) and riverine-type (Bubalus bubalis) water buffaloes." Comparative Immunology, Microbiology and Infectious Diseases 64 (June 2019): 1–6. http://dx.doi.org/10.1016/j.cimid.2019.01.022.

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LANTZ, Kristen A., and Klaus H. KAESTNER. "Winged-helix transcription factors and pancreatic development." Clinical Science 108, no. 3 (2005): 195–204. http://dx.doi.org/10.1042/cs20040309.

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The forkhead gene family, named after the founding gene member in Drosophila, is characterized by a unique DNA-binding domain. This so-called forkhead box encodes a winged-helix DNA-binding motif, the name of which describes the structure of the domain when bound to DNA. The three Fox (forkhead box) group A genes, Foxa1, Foxa2 and Foxa3, are expressed in embryonic endoderm, the germ layer that gives rise to the digestive system, and contribute to the specification of the pancreas and the regulation of glucose homoeostasis. Deletion of the Foxa2 gene in pancreatic β-cells in mice results in a p

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Yamauchi, Takuro, Fumiyoshi Fujishima, Masatoshi Hashimoto, et al. "Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes." Cancers 13, no. 17 (2021): 4473. http://dx.doi.org/10.3390/cancers13174473.

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Necroptosis is a pivotal process in cancer biology; however, the clinical significance of necroptosis in esophageal squamous cell carcinoma (ESCC) has remained unknown. Therefore, in this study, we aimed to verify the potential involvement of necroptosis in the clinical outcome, chemotherapeutic resistance, and tumor microenvironment of ESCC. Mixed lineage kinase domain-like protein (MLKL) and phosphorylated MLKL (pMLKL) were immunohistochemically examined in 88 surgically resected specimens following neoadjuvant chemotherapy (NAC) and 53 pre-therapeutic biopsy specimens, respectively. Tumor-i

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Long, Yu, Yuqing He, Fengming Jie, et al. "Kuijieling-Containing Serum Regulates Th17 and Treg Cell Differentiation by Inhibiting STAT3 Signaling In Vitro." Evidence-Based Complementary and Alternative Medicine 2019 (August 25, 2019): 1–9. http://dx.doi.org/10.1155/2019/7837989.

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Object. To investigate the effect of Kuijieling (KJL) on the balance between T helper 17 (Th17) and regulatory T (Treg) cells in peripheral blood mononuclear cells (PBMC) in vitro and explore the underlying mechanism. Materials and Methods. PBMCs isolated from rats were stimulated with transforming growth factor-β, interleukin (IL)-6, and IL-23 to induce the imbalance of Th17 and Treg cells and were treated with 10, 5, or 2.5% KJL-containing serum. The proportion of Th17 or Treg cells in CD4+ T cells was analyzed by flow cytometry, the concentrations of IL-17, IL-21, and IL-10 were assayed by

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Sung, Yoon-Young, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, and Ho Kyoung Kim. "Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice." Mediators of Inflammation 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/7506808.

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Illicium verum is used in traditional medicine to treat inflammation. The study investigates the effects of IVE and its component, trans-anethole (AET), on airway inflammation in ovalbumin- (OVA-) induced asthmatic mice. Asthma was induced in BALB/c mice by systemic sensitization to OVA, followed by intratracheal, intraperitoneal, and aerosol allergen challenges. IVE and AET were orally administered for four weeks. We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronc

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Soklic, Tanja Kosak, Matija Rijavec, Mira Silar, et al. "Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps." Radiology and Oncology 53, no. 3 (2019): 323–30. http://dx.doi.org/10.2478/raon-2019-0029.

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Abstract Background Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically.

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Yamamoto, Hirotaka, Katsutaro Morino, Yoshihiko Nishio, et al. "MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3." American Journal of Physiology-Endocrinology and Metabolism 303, no. 12 (2012): E1419—E1427. http://dx.doi.org/10.1152/ajpendo.00097.2012.

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MicroRNAs (miRNAs) are important posttranscriptional regulators of various biological pathways. In this study, we focused on the role of miRNAs during mitochondrial biogenesis in skeletal muscle. The expression of miR-494 was markedly decreased in murine myoblast C2C12 cells during myogenic differentiation, accompanied by an increase in mtDNA. Furthermore, the expression of predicted target genes for miR-494, including mitochondrial transcription factor A (mtTFA) and Forkhead box j3 (Foxj3), was posttranscriptionally increased during myogenic differentiation. Knockdown of miR-494 resulted in i

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Kristensen, B., L. Hegedüs, H. O. Madsen, T. J. Smith, and C. H. Nielsen. "Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis." Clinical & Experimental Immunology 180, no. 1 (2015): 58–69. http://dx.doi.org/10.1111/cei.12557.

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Solomou, Elena E., Katayoun Rezvani, Stephan Mielke, et al. "FOXP3-Positive Regulatory T-Cells in Acquired Aplastic Anemia." Blood 108, no. 11 (2006): 2248. http://dx.doi.org/10.1182/blood.v108.11.2248.2248.

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Abstract CD4+CD25+ regulatory T cells (Treg) have been hypothesized to control the development and progression of autoimmunity by suppressing autoreactive T cells. Treg are characterized by constitutive expression of membrane CD25 and intracellular expression of the transcription factor forkhead box (FOX) P3. FOXP3 and NF-AT1 have key roles in regulatory T-cell development and function: induction of FOXP3 in naïve T cells by gene transfer results in gain of a regulatory phenotype, and NF-AT1 modulates transcription of FOXP3. Treg display their suppressive properties on CD4+ CD25- T cells when

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Jiang, Minlin, Chunyan Wu, Liping Zhang, et al. "FOXP3-based immune risk model for recurrence prediction in small-cell lung cancer at stages I–III." Journal for ImmunoTherapy of Cancer 9, no. 5 (2021): e002339. http://dx.doi.org/10.1136/jitc-2021-002339.

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BackgroundImmunotherapies may prolong the survival of patients with small-cell lung cancer (SCLC) to some extent. The role of forkhead box protein P3 (FOXP3) in tumor microenvironment (TME) remains controversial. We aimed to examine FOXP3-related expression characteristics and prognostic values and to develop a clinically relevant predictive system for SCLC.MethodsWe enrolled 102 patients with histologically confirmed SCLC at stages I–III. Through immunohistochemistry, we determined the expression pattern of FOXP3 and its association with other immune biomarkers. By machine learning and statis

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Shin, Seung-Heon, Yee-Hyuk Kim, Mi-Kyung Ye, and Sung-Yong Choi. "Immunopathologic Characteristics of Nasal Polyps in Adult Koreans: A Single-Center Study." American Journal of Rhinology & Allergy 31, no. 3 (2017): 168–73. http://dx.doi.org/10.2500/ajra.2017.31.4423.

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Background Chronic rhinosinusitis with nasal polyps (NP) (CRSwNP) is classified into eosinophilic and noneosinophilic types based on the level of tissue eosinophilia. The immunopathologic features of Western and Asian CRSwNP differ. Objectives The aim of this study was to investigate the immunopathologic characteristics of Korean patients with eosinophilic NP versus noneosinophilic NP and those with atopic NP versus nonatopic NP. Methods Tissue samples were collected from 81 patients with NP and 24 controls. The clinical characteristics of all the patients were analyzed. Tissues were investiga

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Sakamoto, Akemi, Masahiko Hatano, Jun Iwai, Yasuyuki Higashimoto, Hideo Yoshida, and Takeshi Saito. "Systemic and Local Cytokine Profile in Biliary Atresia." European Journal of Pediatric Surgery 27, no. 03 (2016): 280–87. http://dx.doi.org/10.1055/s-0036-1592136.

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Purpose Systemic and local immune environments in human biliary atresia (BA) were analyzed. Methods Plasma concentrations of 19 inflammatory components in 16 preoperative BA patients (median age, 51 days), 13 normal controls (NCs) (44 days), and 15 cholestatic controls (CC) (23 days) were measured using flow cytometry, and compared according to post-Kasai outcomes in BA patients. Hepatic mRNA levels of representative helper T (Th) cell cytokines and forkhead box protein 3 (FoxP3) quantified by real-time reverse transcription polymerase chain reaction were compared between BA and non-BA. Result

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Chen, Dongmei, Yufei Yang, and Peiying Yang. "Quxie Capsule Inhibits Colon Tumor Growth Partially Through Foxo1-Mediated Apoptosis and Immune Modulation." Integrative Cancer Therapies 18 (January 2019): 153473541984637. http://dx.doi.org/10.1177/1534735419846377.

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Quxie capsule (QX), a herbal remedy used in traditional Chinese medicine, is routinely used in advanced colorectal cancer treatment in Xiyuan Hospital in Beijing, China. However, the mechanism(s) underlying the effect of QX in colorectal cancer remain unclear, which hampers the optimal use of QX for the treatment of the disease. The transcription factor forkhead box O1 (Foxo1) plays important roles in regulation of cell cycle, apoptosis, and immune response in various cancers. In this study, we examined the antitumor efficacy of QX in a mouse model of colorectal cancer and further investigated

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Sagaert, Xavier, Pascale de Paepe, Louis Libbrecht, et al. "Forkhead Box Protein P1 Expression in Mucosa-Associated Lymphoid Tissue Lymphomas Predicts Poor Prognosis and Transformation to Diffuse Large B-Cell Lymphoma." Journal of Clinical Oncology 24, no. 16 (2006): 2490–97. http://dx.doi.org/10.1200/jco.2006.05.6150.

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Purpose Gene expression profiling studies have reported upregulated mRNA expression of forkhead box protein P1 (FOXP1) in response to normal B-cell activation and high expression in a poor prognosis subtype of diffuse large B-cell lymphoma (DLBCL). Recently, it was also found that FOXP1 rearrangements and expression of its protein occur in mucosa-associated lymphoid tissue (MALT) lymphomas. In this study, we investigated FOXP1 expression in its relationship to morphology, genetic features, and prognosis in a series of 70 MALT lymphomas. Patients and Methods All samples were morphologically rev

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Kim, Seung-Hyung, Jung-Hee Hong, Won-Kyung Yang, Hyo-Jung Kim, Hyo-Jin An та Young-Cheol Lee. "Cryptotympana pustulata Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice". Molecules 26, № 7 (2021): 1854. http://dx.doi.org/10.3390/molecules26071854.

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Cicadae Periostracum (CP), derived from the slough of Cryptotympana pustulata, has been used as traditional medicine in Korea and China because of its diaphoretic, antipyretic, anti-inflammatory, antioxidant, and antianaphylactic activities. The major bioactive compounds include oleic acid (OA), palmitic acid, and linoleic acid. However, the precise therapeutic mechanisms underlying its action in asthma remain unclear. The objective of this study was to determine the antiasthmatic effects of CP in an ovalbumin (OVA)-induced asthmatic mouse model. CP and OA inhibited the inflammatory cell infil

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Strakova, Veronika, Lenka Elblova, Matthew B. Johnson, et al. "Screening of monogenic autoimmune diabetes among children with type 1 diabetes and multiple autoimmune diseases: is it worth doing?" Journal of Pediatric Endocrinology and Metabolism 32, no. 10 (2019): 1147–53. http://dx.doi.org/10.1515/jpem-2019-0261.

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Abstract Background Paediatric type 1 diabetes (T1D) and rare syndromes of monogenic multi-organ autoimmunity share basic features such as full insulin dependency and the presence of circulating beta-cell autoantibodies. However, the aetiopathogenesis, natural course and treatment of these conditions differ; therefore, monogenic multi-organ autoimmunity requires early recognition. We aimed to search for these monogenic conditions among a large cohort of children with T1D. Methods Of 519 children with T1D followed-up in a single centre, 18 had multiple additional autoimmune conditions – either

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He, Xionghui, and Kejian Zou. "MiRNA-96-5p contributed to the proliferation of gastric cancer cells by targeting FOXO3." Journal of Biochemistry 167, no. 1 (2019): 101–8. http://dx.doi.org/10.1093/jb/mvz080.

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Abstract Various microRNAs (miRNAs, miRs) and the forkhead box O (FOXO) family proteins have been shown to influence gastric cancer progression and development. Here, we aimed to identify the gastric cancer related miRNAs and their relationship with the FOXO family. MiRNA profiles were generated by miRNA microarray screening from pre-operative plasma samples. Quantitative reverse transcription PCR and western bolt were used to determine the expression levels of miR-96 and FOXO family. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay and colony formation assay were used to tes

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Mielke, Stephan, Katayoun Rezvani, Bipin N. Savani, et al. "Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease." Blood 110, no. 5 (2007): 1689–97. http://dx.doi.org/10.1182/blood-2007-03-079160.

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Abstract Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (Tregs) with incomplete removal of alloactivated CD25+ T cells could increase the risk of aGvHD. We therefore measured Tregs in the blood of 16 patients receiving a T-cell–depleted allograft together with anti–CD25-IT–treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. Tregs were characterize

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Reale, Marcella, Lucia Velluto, Marta Di Nicola, et al. "Cholinergic Markers and Cytokines in OSA Patients." International Journal of Molecular Sciences 21, no. 9 (2020): 3264. http://dx.doi.org/10.3390/ijms21093264.

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The role of inflammation and dysfunction of the cholinergic system in obstructive sleep apnea (OSA) has not exhaustively clarified. Thus, in this study, we explore the non-neuronal cholinergic system and the balance of T helper (Th) 17- and T regulatory (Treg)-related cytokines in OSA patients. The study includes 33 subjects with obstructive sleep apnea and 10 healthy controls (HC). The expression levels of cholinergic system component, RAR-related orphan receptor (RORc), transcription factor forkhead box protein 3 (Foxp3) and cytokines were evaluated. Th17- and Treg-related cytokines, choline

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Zhang, Yuan, Xin Wang, Xiao Zhang, et al. "RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation." Proceedings of the National Academy of Sciences 116, no. 3 (2018): 976–81. http://dx.doi.org/10.1073/pnas.1812536116.

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IFN–stimulated genes (ISGs) are essential effectors of the IFN-dependent antiviral immune response. Dysregulation of ISG expression can cause dysfunctional antiviral responses and autoimmune disorders. Epitranscriptomic regulation, such as N6-methyladenosine (m6A) modification of mRNAs, plays key roles in diverse biological processes. Here, we found that the m6A “reader” YT521-B homology domain-containing family 3 (YTHDF3) suppresses ISG expression under basal conditions by promoting translation of the transcription corepressor forkhead box protein O3 (FOXO3). YTHDF3 cooperates with two cofact

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Anderson, Per, and Elena Gonzalez-Rey. "Vasoactive Intestinal Peptide Induces Cell Cycle Arrest and Regulatory Functions in Human T Cells at Multiple Levels." Molecular and Cellular Biology 30, no. 10 (2010): 2537–51. http://dx.doi.org/10.1128/mcb.01282-09.

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ABSTRACT Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory neuropeptide that, by inhibiting Th1-driven responses and inducing the emergence of regulatory T cells (Treg), has been proven successful in the induction of tolerance in various experimental models of autoimmune disorders. Here, we investigate the molecular mechanisms involved in VIP-induced tolerance. VIP treatment in the presence of T-cell receptor (TCR) signaling and CD28 costimulation induced cell cycle arrest in human T cells. VIP blocked G1/S transition and inhibited the synthesis of cyclins D3 and E and the acti

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Mounier, Catherine, Victor Dumas, and Barry I. Posner. "Regulation of Hepatic Insulin-Like Growth Factor-Binding Protein-1 Gene Expression by Insulin: Central Role for Mammalian Target of Rapamycin Independent of Forkhead Box O Proteins." Endocrinology 147, no. 5 (2006): 2383–91. http://dx.doi.org/10.1210/en.2005-0902.

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The expression of IGF-binding protein-1 (IGFBP-1) is induced in rat liver by dexamethasone and glucagon and is completely inhibited by 100 nm insulin. Various studies have implicated phosphatidylinositol 3-kinase, protein kinase B (Akt), phosphorylation of the transcription factors forkhead in rhabdomyosarcoma 1 (Foxo1)/Foxo3, and the mammalian target of rapamycin (mTOR) in insulin’s effect. In this study we examined insulin regulation of IGFBP-1 in both subconfluent and confluent hepatocytes. In subconfluent hepatocytes, insulin inhibition of IGFBP-1 mRNA levels was blocked by inhibiting PI3

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Wu, Xiuli, Qifa Liu, Can Liu, Zhiping Fan, Li Xuan, and Jing Sun. "The Expression of GATA-3 and FoxP3 Genes and the Frequency of Tregs Are Correlated with Gvhd Following Allogeneic HSCT." Blood 116, no. 21 (2010): 5181. http://dx.doi.org/10.1182/blood.v116.21.5181.5181.

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Abstract Abstract 5181 Objective Hematopoietic stem cell transplantation (HSCT) is a common therapeutic option for leukemia, but its use is limited by mortality due to graft-versus-host-disease (GVHD). Naturally occurring regulatory T cells (Tregs) are mediators of immunologic tolerance that attenuate GVHD in experimental models. Tregs were first defined by a CD4+CD25+ phenotype, but subsequent studies identified forkhead box protein 3 (FoxP3) as a highly specific marker in both mouse and human T cells with regulatory function. GATA-3 is a member of the GATA family of transcription factors, an

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