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Journal articles on the topic 'Fragile Sex'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Jay, Jennifer W. "Fragile Scholar: Power and Masculinity in Chinese Culture (review)." Journal of the History of Sexuality 15, no. 2 (2005): 345–47. http://dx.doi.org/10.1353/sex.2007.0006.

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Patel, Nrupathunga, and G. S. Venumadhava. "Child sex abuse - Combat on fragile mind." Asian Journal of Research in Social Sciences and Humanities 7, no. 9 (2017): 366. http://dx.doi.org/10.5958/2249-7315.2017.00470.1.

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3

Nielsen, Karen Brøndum, John M. Opitz, and James F. Reynolds. "Sex chromosome aneuploidy in fragile X carriers." American Journal of Medical Genetics 23, no. 1-2 (1986): 537–44. http://dx.doi.org/10.1002/ajmg.1320230146.

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4

Berney, T. P. "Fragile X syndrome and disorders of the sex chromosome." Current Opinion in Psychiatry 2, no. 5 (1989): 593–98. http://dx.doi.org/10.1097/00001504-198910000-00002.

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Westmark, Cara J. "Parental Reports on Early Autism Behaviors in Their Children with Fragile X Syndrome as a Function of Infant Feeding." Nutrients 13, no. 8 (2021): 2888. http://dx.doi.org/10.3390/nu13082888.

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This study evaluates the prevalence of autistic behaviors in fragile X syndrome as a function of infant diet. Retrospective survey data from the Fragile X Syndrome Nutrition Study, which included data on infant feeding and caregiver-reported developmental milestones for 190 children with fragile X syndrome enrolled in the Fragile X Online Registry with Accessible Database (FORWARD), were analyzed. Exploratory, sex-specific associations were found linking the use of soy-based infant formula with worse autistic behaviors related to language in females and self-injurious behavior in males. These

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6

Smith, Elizabeth G., Ernest V. Pedapati, Rui Liu, et al. "Sex differences in resting EEG power in Fragile X Syndrome." Journal of Psychiatric Research 138 (June 2021): 89–95. http://dx.doi.org/10.1016/j.jpsychires.2021.03.057.

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7

Schepis, C., R. Palazzo, S. P. Cannavo, R. M. Ragusa, C. Barletta, and E. Spina. "Prevalence of primary cutis verticis gyrata in a psychiatric population: association with chromosomal fragile sites." Acta Dermato-Venereologica 70, no. 6 (1990): 483–86. http://dx.doi.org/10.2340/00015555-70487490.

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The prevalence of cutis verticis gyrata was studied in a psychiatric institutional population of 494 patients, the majority of whom were mentally retarded or had chronic schizophrenia. Twenty-two subjects (21 males and 1 female) were found to have primary cutis verticis gyrata, yielding a prevalence of about 4.5%. The frequency of the scalp disorder was 11.4% among mentally retarded patients and 1.7% in schizophrenic subjects. A cytogenetic study was performed on patients with primary cutis verticis gyrata. In 9 out of 21 subjects there was evidence of chromosomal fragile sites: 5 patients had

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D. Chalap Al-Graw, Eqbal. "Inheritance Ppattern of Fragile X-Syndrome in Iraqi Families." AL-QADISIYAH MEDICAL JOURNAL 4, no. 5 (2017): 204–17. http://dx.doi.org/10.28922/qmj.2008.4.5.204-217.

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This study included five Iraqi families from four provinces, many members who suffered from congenital fragile X chromosome. Five family pedigrees were drawn up very clearly to follow the pattern of fragile X chromosome. The study showed that there is marked discrepancy in the sex ratio, with only boys affected. Females are affected only if they were homozygous, Heterozygous (carrier) females were clinically normal but transmitted the disease to 35% of their sons, and there i s one in two risks that their daughters too were carriers. The fragile X chromosome was never transmitted directly from

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Abolghasemi, Armita, Maria Paulina Carullo, Ester Cisneros Aguilera, et al. "Alteration of Fatty Acid Profile in Fragile X Syndrome." International Journal of Molecular Sciences 23, no. 18 (2022): 10815. http://dx.doi.org/10.3390/ijms231810815.

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Fragile X Syndrome (FXS) is the most prevalent monogenic cause of Autism Spectrum Disorders (ASDs). Despite a common genetic etiology, the affected individuals display heterogenous metabolic abnormalities including hypocholesterolemia. Although changes in the metabolism of fatty acids (FAs) have been reported in various neuropsychiatric disorders, it has not been explored in humans with FXS. In this study, we investigated the FA profiles of two different groups: (1) an Argentinian group, including FXS individuals and age- and sex-matched controls, and (2) a French-Canadian group, including FXS

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10

Impey, Nick. "Ideas of sex." Alphaville: Journal of Film and Screen Media, no. 1 (August 17, 2011): 76–88. http://dx.doi.org/10.33178/alpha.1.06.

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Both The Night Porter (Cavani) and The Gestapo’s Last Orgy (Canevari) are often referred to as exploitation. Exploitation cinema’s focus on empty excess is in line with the exaggeration/superficiality of “Camp”. Despite Susan Sontag’s separation of “Camp” elements and homosexual-Camp elements, subsequent&#xD;&#xA; commentators have argued that Camp is an exclusively gay critique of the artificial nature of the “performance” of hetero-normative gender roles. My article looks at the ways in which lesbian filmmaker Liliana Cavani discusses queer sexuality through a Camp play on gender rol

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M'charek, Amade. "Fragile differences, relational effects: Stories about the materiality of race and sex." European Journal of Women's Studies 17, no. 4 (2010): 307–22. http://dx.doi.org/10.1177/1350506810377698.

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This article is about the materiality of difference, about race, sex and sexual differences among others. To find out about these differences and their materialities, this article looks not into bodies but rather at how bodies are positioned in spaces and how they are enacted in practice. In the first part of the article, the focus is on the relationality of identities and how they are made and unmade in specific practices. The second part of the article attends to the various histories and practices that are drawn together in one specific body and how they help to enact a particular version o

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Cuéllar Álvarez, Jesús, Aguedo Medardo Treto, and Vivian Margarita Guerra Morales. "Characterization of the Functional State in Fragile Bigger Adults from the Medical Practice." General Medicine and Clinical Practice 1, no. 2 (2018): 01–03. http://dx.doi.org/10.31579/2639-4162/009.

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Context: the fragility of the elderly served in a community health area and to characterize elderlies according to fragility criteria. Objective: to characterize the functional state in fragile bigger adults from the medical practice. Material and Methods: a descriptive, cross-sectional investigation with a quantitative approach was carried out between April 2017 and April 2018. Results: prevailed the alterations of mobility and balance in 54,8 %, only 16,1 % was alterations of the emotional state and 29,0 % was alterations functional cognitive. Conclusion: the presence of several fragility cr

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Vandenberg, Gregory G., Aasritha Thotakura, and Angela L. Scott. "Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects." American Journal of Physiology-Cell Physiology 322, no. 2 (2022): C125—C135. http://dx.doi.org/10.1152/ajpcell.00130.2021.

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Fragile X syndrome (FXS) is a genetic disorder that is characterized by a range of cognitive and behavioral deficits, including mild-moderate intellectual disability. The disease is characterized by an X-linked mutation of the Fmr1 gene, which causes silencing of the gene coding for fragile X mental retardation protein (FMRP), a translational regulator integral for neurodevelopment. Mitochondrial dysfunction has been recently associated with FXS, with reports of increases in oxidative stress markers, reactive oxygen species, and lipid peroxidation being present in the brain tissue. Astrocytes,

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Armstrong, Jessica L., Yiming Chen, Tanishka S. Saraf, and Clinton E. Canal. "Sex Differences in an Fmr1 Knock‐out Mouse Model of Fragile X Syndrome." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.06309.

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15

Yu, Zeyang, Tian-Tian Zhang, Xiaomeng Wang, et al. "Sexual behaviour changes and HIV infection among men who have sex with men: evidence from an open cohort in China." BMJ Open 12, no. 9 (2022): e055046. http://dx.doi.org/10.1136/bmjopen-2021-055046.

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BackgroundThe HIV epidemic in key populations such as men who have sex with men (MSM) is a public health issue of worldwide concern. China has seen an increase in newly diagnosed HIV infections through male–male sexual contact in the past decade. In a long-term cohort, how the complex behaviour pattern of MSM changed and the association with the HIV risk are unclear at present.MethodsThis study was conducted from October 2011 to December 2019 in Tianjin. MSM were recruited by snowball sampling through online and offline ways. Demographic and sexual behavioural data were collected for analysis.

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Barth, Cornelia Anne, Andreas Wladis, Catherine Blake, Prashant Bhandarkar, Sigiriya Aebischer Perone, and Cliona O'Sullivan. "Retrospective observational study of characteristics of persons with amputations accessing International Committee of the Red Cross (ICRC) rehabilitation centres in five conflict and postconflict countries." BMJ Open 11, no. 12 (2021): e049533. http://dx.doi.org/10.1136/bmjopen-2021-049533.

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ObjectivesLimb amputation incidence is particularly high in fragile contexts due to conflict, accidents and poorly managed diabetes. The study aim was to analyse (1) demographic and amputation characteristics of persons with any type of acquired amputation (PwA) and (2) time between amputation and first access to rehabilitation in five conflict and postconflict countries.DesignA retrospective, observational study analysing differences in demographic and clinical factors and time to access rehabilitation between users with traumatic and non-traumatic amputations.SettingFive countries with the h

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Teo, Clara R. L., Hai-Yang Law, Caroline G. Lee, and Samuel S. Chong. "Screening for CGG Repeat Expansion in the FMR1 Gene by Melting Curve Analysis of Combined 5′ and 3′ Direct Triplet-Primed PCRs." Clinical Chemistry 58, no. 3 (2012): 568–79. http://dx.doi.org/10.1373/clinchem.2011.174615.

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Abstract BACKGROUND CGG repeat expansions in the FMR1 (fragile X mental retardation 1) gene are associated with fragile X syndrome, fragile X–associated tremor/ataxia syndrome, and fragile X–associated primary ovarian insufficiency. We evaluated the use of melting curve analysis (MCA) of triplet-primed PCR (TP-PCR) assays as a rapid screening tool for the positive identification of expanded FMR1 alleles in men and women. METHODS Both 5′- and 3′-weighted direct TP-PCRs (dTP-PCRs) were evaluated on 29 cell line–derived DNA samples and 44 blinded clinical samples. The presence of expansions was i

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Afshar, Sepideh, Sevda Lule, Gengyang Yuan, et al. "Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model." Translational Neuroscience 13, no. 1 (2022): 80–92. http://dx.doi.org/10.1515/tnsci-2022-0217.

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Abstract Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS and growing evidence of a role of metabotropic glutamate subtype 5 receptors (mGluR5) in the pathophysiology of the disorder, we investigated mGluR5 function in FMR1 Knockout (FMR1-KO) mice and age- and sex-matched control mice using longitudinal positron emission tomography (PET) imaging to better understand the disorder. The studies were

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Joseph, Lauren J., and Pamela Black. "Who's the Man? Fragile Masculinities, Consumer Masculinities, and the Profiles of Sex Work Clients." Men and Masculinities 15, no. 5 (2012): 486–506. http://dx.doi.org/10.1177/1097184x12458591.

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Adayev, Tatyana, Giuseppe LaFauci, Weimin Xu, et al. "Development of a Quantitative FMRP Assay for Mouse Tissue Applications." Genes 12, no. 10 (2021): 1516. http://dx.doi.org/10.3390/genes12101516.

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Fragile X syndrome results from the absence of the FMR1 gene product—Fragile X Mental Retardation Protein (FMRP). Fragile X animal research has lacked a reliable method to quantify FMRP. We report the development of an array of FMRP-specific monoclonal antibodies and their application for quantitative assessment of FMRP (qFMRPm) in mouse tissue. To characterize the assay, we determined the normal variability of FMRP expression in four brain structures of six different mouse strains at seven weeks of age. There was a hierarchy of FMRP expression: neocortex > hippocampus > cerebellum >

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Eisenberg, Avigail. "Context, Cultural Difference, Sex and Social Justice." Canadian Journal of Political Science 35, no. 3 (2002): 613–28. http://dx.doi.org/10.1017/s0008423902778372.

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Three concerns have motivated scholars to examine what is often called the “dilemma” between sexual equality and cultural autonomy. First, by far the majority of the world's women fail to enjoy the legal , political, social and economic status enjoyed by men and, moreover, one of the main explanations for their relatively deprived state is found in the cultural traditions and practices that govern their lives . Second, even though sexism is ubiquitous, the existence of gender inequality within minority groups renders vulnerable the claims of groups to cultural autonomy, especially claims made

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Ma, Jinyi. "Application of Different Methods in Animal Sex Control Technology." Theoretical and Natural Science 112, no. 1 (2025): 80–84. https://doi.org/10.54254/2753-8818/2025.au23419.

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Animal sex control technology enables targeted offspring gender selection in livestock through artificial reproductive intervention, offering significant economic value. It leverages biological differences in X/Y sperm DNA content, surface proteins, and metabolic activity. This research will discuss the application performance of different methods in animal sex control technology. Flow cytometry (85%-95% accuracy via fluorescent sorting) is high cost, low efficiency, and damage to fragile sperm (e.g., 40% survival loss in pigs), thus limiting the industrial use. Immunological methods (TLR7/8 p

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Mittleman, Joel. "Sexual Orientation and School Discipline: New Evidence From a Population-Based Sample." Educational Researcher 47, no. 3 (2018): 181–90. http://dx.doi.org/10.3102/0013189x17753123.

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Sexual minorities’ risk for exclusionary discipline is a commonly cited indicator of the challenges that these students face. The current study addresses this issue by introducing a new data source for research on sexual minority students: the Fragile Families and Childhood Wellbeing Study. In this geographically diverse, population-based sample, I find that sexual minorities continue to face higher rates of discipline than their peers. However, this risk is highly stratified by sex: Same-sex attraction is associated with 95% higher odds of discipline among girls but no apparent discipline ris

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Hunt, Patricia A., and Paul S. Burgoyne. "A tissue-specific fragile site associated with the sex reversed (Sxr) mutation in the mouse." Chromosoma 96, no. 1 (1987): 67–71. http://dx.doi.org/10.1007/bf00285886.

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Garribba, Lorenza, Victoria A. Bjerregaard, Marisa M. Gonçalves Dinis, et al. "Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells." Proceedings of the National Academy of Sciences 117, no. 28 (2020): 16527–36. http://dx.doi.org/10.1073/pnas.1921219117.

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Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within theFRAXAlocus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disorder associated with cognitive impairment. Although folate-sensitive RFSs share many features with common fragile sites (CFSs; which are found in all individuals), they are induced by different stresses and share no sequence similarity. It is known that a pathway (termed MiDAS) is employed to complete t

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Boeck, Brynne, Yingqing Mao, Ruo-Pan Huang, and Cara J. Westmark. "Soy Protein Isolate Affects Blood and Brain Biomarker Expression in a Mouse Model of Fragile X." International Journal of Molecular Sciences 26, no. 13 (2025): 6137. https://doi.org/10.3390/ijms26136137.

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Fragile X syndrome is characterized by the diminished expression of the fragile X messenger ribonucleoprotein (FMRP), a ubiquitously expressed RNA binding protein with numerous functions in cells. Our prior work found significant differences in physiological and behavioral outcomes as a function of FMRP levels and in response to diet in mice. Here, we assess protein biomarker levels as a function of FMRP levels, sex and matched casein and soy protein isolate-based purified ingredient diets in Fmr1KO and littermate mice. Brain regions (cortex, hippocampus, and hypothalamus) and blood plasma wer

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Kikkawa, *Takako, Sara Ebrahimiazar, and Noriko Osumi. "ABSENCE OF FMRP MODULATES BRAIN DEVELOPMENT IN A SEX- SPECIFIC MANNER." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i66. https://doi.org/10.1093/ijnp/pyae059.113.

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Abstract Background Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the FMR1 gene, leading to the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein. There is sex-specificity in the symptoms of FXS patients, such as social interaction defects in female patients (Reiss et al., 1988). Sex-specific behaviors are also observed in Fmr1-knockout (KO) mice, such as more repetitive behavior in females (Nolan et al., 2017). The expression of FMRP starts from the embryonic stage and localizes to the neural stem/progenitor cells and neurons, co

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Gysin, Fátima, and François Gysin. "Prostitution use has non sexual functions - case report of a depressed psychiatric out-patient." F1000Research 2 (May 29, 2013): 70. http://dx.doi.org/10.12688/f1000research.2-70.v2.

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Case: A shy, depressed 30 year old male discussed his frequent ego-syntonic indoor prostitution consumption in small peer groups. Several distinctive non-sexual functions of this paid sex habit were identified.Design and method: The patient had 40 hourly psychiatric sessions in the private practice setting over 14 months. The Arizona Sexual Experience Scale was applied to compare the subjective appraisal of both paid sex and sex in a relationship. The informal Social Atom elucidates social preferences and the Operationalized Psychodynamic Diagnostic-procedure was applied to describe a dominant

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Clemente, Tommaso, Domenico Pontillo, Vincenzo Malagnino, et al. "Cancer in people with multidrug-resistant HIV." AIDS 38, no. 12 (2024): 1801–6. http://dx.doi.org/10.1097/qad.0000000000003952.

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Retrospective, cohort analysis including people with HIV and 4-class drug resistance (4DR). The 8-year probability of malignancy after first evidence of 4DR was 12%, with an incidence of 1.6/100 person years of follow-up. Cancer risk tended to increase with higher precancer viremia copy-years adjusted for time [per 1 − log10 copies/ml higher: adjusted hazard ratio (aHR) = 1.35; 95% confidence interval (95% CI) = 0.98–1.85] and male sex-assigned-at-birth (aHR = 2.50; 95% CI = 0.86–7.27). Efforts to achieve long-term undetectability, risk factor control, prevention, and more aggressive cancer sc

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Konečná, Irena Ferčíková. "Excluded but Fighting: Where Are the Voices of Sex Workers and Their Allies in EU Anti-Trafficking Policymaking?" Social Sciences 13, no. 3 (2024): 148. http://dx.doi.org/10.3390/socsci13030148.

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The ‘end demand’ approach to prostitution has been popping up in Europe through the anti-trafficking debate and receives increasing attention on the international agenda. It is well recognized that improving workers’ rights, increasing unionization and collective bargaining coverage are effective strategies for tackling trafficking. However, with regard to sexual exploitation, focus is not on these strategies but instead on the abolition of the entire sex industry with the help of criminal justice systems. In first decade after the Palermo Protocol (2000), international organizations (IGOs) pr

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Weber, Jayne, Elizabeth Smith, Elizabeth Berry-Kravis, Diego Cadavid, David Hessl, and Craig Erickson. "Voice of People with Fragile X Syndrome and Their Families: Reports from a Survey on Treatment Priorities." Brain Sciences 9, no. 2 (2019): 18. http://dx.doi.org/10.3390/brainsci9020018.

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To date, there has been limited research on the primary concerns and treatment priorities for individuals with fragile X syndrome (FXS) and their families. The National Fragile X Foundation in collaboration with clinical investigators from industry and academia constructed a survey to investigate the main symptoms, daily living challenges, family impact, and treatment priorities for individuals with FXS and their families, which was then distributed to a large mailing list. The survey included both structured questions focused on ranking difficulties as well as qualitative analysis of open-end

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Grasso, Antonella, Antonio Di Zazzo, Giuseppe Giannaccare, et al. "Sex Hormones Related Ocular Dryness in Breast Cancer Women." Journal of Clinical Medicine 10, no. 12 (2021): 2620. http://dx.doi.org/10.3390/jcm10122620.

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Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Methods: A literature review regarding the role of sex hormone changes and systemic hormonal replacement treatments (SH

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Khan, Ishvah, and Bushra Siddiqui. "Objectification and Confinement of Female Sexuality in Austen’s Emma and its Literary Adaptation: A Postfeminist Comparative Analysis." Journal of Policy Research 10, no. 2 (2024): 666–73. http://dx.doi.org/10.61506/02.00283.

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This research explores the construction of female sexuality in the literary adaptation Emma (2020) directed by Autumn de Wilde through a postfeminist lens. The research is based on Iris Marion Young’s theory of oppression examining the feminine body comportment and mobility. The movement and ability of females to perform household and outdoor chores is restricted by the male gender. The restriction on the sexuality of a woman develops a fragile and dependent self. The female characters of Emma (1815) reveal the oppressive structures that confine feminine activities under the definition of mora

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Genovese, Ann C., and Merlin G. Butler. "Systematic Review: Fragile X Syndrome Across the Lifespan with a Focus on Genetics, Neurodevelopmental, Behavioral and Psychiatric Associations." Genes 16, no. 2 (2025): 149. https://doi.org/10.3390/genes16020149.

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Background/Objectives: Fragile X syndrome (FXS) is one of the most common genetic causes of intellectual developmental disability and autism spectrum disorder (ASD), second only to Down’s syndrome and associated with a broad range of neurodevelopmental, behavioral, and psychiatric challenges. FXS may be present in infants or young children with characteristic dysmorphic features, developmental delays, and behavioral challenges. The diagnosis of FXS is confirmed by the molecular genetic testing of the FMR1 gene encoding fragile X messenger RNA-binding protein (FMRP), involved in regulating the

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Jiang, Anlong, Le Wang, Justin Y. D. Lu, et al. "Sex Differences in Dopamine Receptor Signaling in Fmr1 Knockout Mice: A Pilot Study." Brain Sciences 11, no. 11 (2021): 1398. http://dx.doi.org/10.3390/brainsci11111398.

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Fragile X syndrome (FXS) is an X-chromosome-linked dominant genetic disorder that causes a variable degree of cognitive dysfunction and developmental disability. Current treatment is symptomatic and no existing medications target the specific cause of FXS. As with other X-linked disorders, FXS manifests differently in males and females, including abnormalities in the dopamine system that are also seen in Fmr1-knockout (KO) mice. We investigated sex differences in dopamine signaling in Fmr1-KO mice in response to L-stepholidine, a dopamine D1 receptor agonist and D2 receptor antagonist. We foun

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Westmark, Cara J. "Consumption of Breast Milk Is Associated with Decreased Prevalence of Autism in Fragile X Syndrome." Nutrients 13, no. 6 (2021): 1785. http://dx.doi.org/10.3390/nu13061785.

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Breastfeeding is associated with numerous health benefits, but early life nutrition has not been specifically studied in the neurodevelopmental disorder fragile X syndrome (FXS). Herein, I evaluate associations between the consumption of breast milk during infancy and the prevalence of autism, allergies, diabetes, gastrointestinal (GI) problems and seizures in FXS. The study design was a retrospective survey of families enrolled in the Fragile X Online Registry and Accessible Research Database (FORWARD). There was a 1.7-fold reduction in the prevalence of autism in FXS participants who were fe

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Westmark, Pamela R., Greg Lyon, Alejandra Gutierrez, et al. "Effects of Soy Protein Isolate on Fragile X Phenotypes in Mice." Nutrients 16, no. 2 (2024): 284. http://dx.doi.org/10.3390/nu16020284.

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Obesity is a pediatric epidemic that is more prevalent in children with developmental disabilities. We hypothesize that soy protein-based diets increase weight gain and alter neurobehavioral outcomes. Our objective herein was to test matched casein- and soy protein-based purified ingredient diets in a mouse model of fragile X syndrome, Fmr1KO mice. The experimental methods included assessment of growth; 24-7 activity levels; motor coordination; learning and memory; blood-based amino acid, phytoestrogen and glucose levels; and organ weights. The primary outcome measure was body weight. We find

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Nasiri, F., F. Mahjoubi, F. Manouchehry, F. Razazian, F. Mortezapour, and M. Rahnama. "Cytogenetic Findings in Mentally Retarded Iranian Patients." Balkan Journal of Medical Genetics 15, no. 2 (2012): 29–34. http://dx.doi.org/10.2478/bjmg-2013-0004.

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ABSTRACT We conducted a cytogenetic study on 865 individuals with idiopathic mental retardation (MR) who were admitted to the Cytogenetics Department of the Iran Blood Transfusion Organisation (IBTO) Research Centre, Tehran, Iran; these were performed on blood samples using conventional staining methods. Chromosome anomalies were identified in 205 of the patients (23.6%). The majority were Down’s syndrome cases (n = 138). In 33 males, a positive fragile X anomaly was found .The remainder (n = 34) had other chromosomal abnormalities including structural chromosome aberrations (n = 23), marker c

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Maisaroh, Umi. "THE FRAGILE MASCULINE: GENDER, SEXUALITY, RACE AND RELIGION AS A COMPLEXITY OF ELISCHA'S CHARACTER IN “LOVE ME HARDER” BY CHICKS* (2020)." TONIL: Jurnal Kajian Sastra, Teater dan Sinema 19, no. 2 (2022): 59–69. http://dx.doi.org/10.24821/tnl.v19i2.7267.

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Performance elements such as stage properties, actors, text, music, lighting, and other elements appear when the performance represents symbols and meanings. This study tries to deconstruct ideas about gender and sex through an exploration of reading the meaning of the elements of the 'Love Me Harder' performance by the theatre group CHICKS*. The performance was held at the LOFFT Leipzig Theater in February 2020. The data collected was from watching the performance booklet and the theatre group's website. As a theoretical framework, this research will use literature studies, for example, theor

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Muhammad Rizwan Yasin, Dr. Jamil Ahmad Nutkani та Sohail Akhtar. "بچوں کو جنسی تعلیم دینے سے متعلق مختلف رویے:مغربی ماہرین کے مقالات اور اسلامی تعلیمات کا مطالعہ". Al-Qamar 2, № 1 (2019): 197–210. https://doi.org/10.53762/72bggq90.

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This article studies the different attitudes towards sex education in children in the light of research articles by Western Scholars and Islamic teachings. It finds that according to Western scholars, sexual health of young people is much better in the countries where the awareness about sexual relationship is provided from early age. Sex, especially among youngsters before any legal marital status, has become a central concern for all societies of the world. This concern is increased by HIV-related diseases through this act. The only way to reduce the spread of HIV among young people, accordi

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Blackmon, Heath, and Jeffery P. Demuth. "The fragile Y hypothesis: Y chromosome aneuploidy as a selective pressure in sex chromosome and meiotic mechanism evolution." BioEssays 37, no. 9 (2015): 942–50. http://dx.doi.org/10.1002/bies.201500040.

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Lefkovitz, Alison. "“The Peculiar Anomaly”: Same-Sex Infidelity in Postwar Divorce Courts." Law and History Review 33, no. 3 (2015): 665–701. http://dx.doi.org/10.1017/s0738248015000243.

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It was a simple tale of betrayal. In 1950, a Pennsylvania husband returned home from a business trip to find his wife—known to us today only by her initials CD—having sex with the female athletic director of a local school. This wife was only one of many women caught having sex with other women in the era following World War II. Although many closeted men and women enjoyed vibrant sexual and social lives in gay and lesbian communities, sometimes commanding officers, bosses, and police officers caught and punished men and women engaging in “deviant” sexual activity. Punishments ranged from arre

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Inaba, Yoshimi, Amy S. Herlihy, Charles E. Schwartz, et al. "Fragile X–related element 2 methylation analysis may provide a suitable option for inclusion of fragile X syndrome and/or sex chromosome aneuploidy into newborn screening: a technical validation study." Genetics in Medicine 15, no. 4 (2012): 290–98. http://dx.doi.org/10.1038/gim.2012.134.

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van Eijk, Marieke. "Transgenderzorg als zorgpraktijk - De werking van cultuur, geld en instituties in een genderidentiteitskliniek in de Verenigde Staten." Tijdschrift voor Genderstudies 17, no. 1 (2014): 47–64. http://dx.doi.org/10.5117/tvg2014.1.eijk.

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Transgender health care as a care practice. Culture, money, and institutions at work in a gender identity clinic in the United States While often approached as a field structured by stringent socio-medical ideas about gender and sex, transgender health care is, in addition, like any other medical field, also shaped by local ideologies of health and well-being, health insurance regulations, and institutional administrative processes. Drawing upon ethnographic fieldwork conducted in a gender identity clinic in the Midwestern United States, I offer a tripartite approach to understanding the inter

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Giulivi, Cecilia, Eleonora Napoli, Flora Tassone, Julian Halmai, and Randi Hagerman. "Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation." Biochemical Journal 473, no. 21 (2016): 3871–88. http://dx.doi.org/10.1042/bcj20160585.

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Carriers of premutation CGG expansions in the fragile X mental retardation 1 (FMR1) gene are at higher risk of developing a late-onset neurodegenerative disorder named Fragile X-associated tremor ataxia syndrome (FXTAS). Given that mitochondrial dysfunction has been identified in fibroblasts, PBMC and brain samples from carriers as well as in animal models of the premutation and that mitochondria are at the center of intermediary metabolism, the aim of the present study was to provide a complete view of the metabolic pattern by uncovering plasma metabolic perturbations in premutation carriers.

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Goo, Kelly, Mina Silberberg, Howard Eisenson, Fred Johnson, and Sandra Stinnett. "MEASURING SPECIALTY CARE UTILIZATION AMONG MEDICALLY FRAGILE, LOW-INCOME OLDER OR DISABLED ADULTS." Innovation in Aging 6, Supplement_1 (2022): 786. http://dx.doi.org/10.1093/geroni/igac059.2841.

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Abstract The purpose of this research was to quantify the rates of specialty care referral completion and identify variables associated with successful completion among a population of low-income, elderly and/or disabled homebound patients with barriers to accessing office-based care. This was a cross-sectional study using descriptive and multivariate predictive analysis of specialty care referral completion, operationalized as attending an appointment of the same specialty care type within 6 months of being referred. Independent variables include patient age, sex, race, marital status, health

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Carneiro, Alexandre Mansuê Ferreira, Yan Corrêa Rodrigues, Maria Fani Dolabela, et al. "Social Experiences, Discrimination, and Violence among Men Who Have Sex with Men in a Northern Brazilian Capital." Healthcare 11, no. 7 (2023): 964. http://dx.doi.org/10.3390/healthcare11070964.

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Men who have sex with men who suffer stigmatization and discrimination become more fragile in facing life’s problems, such as the search for treatment in health services. In the present study, the social aspects related to discrimination and violence among men who have sex with men in Belém, Pará, are evaluated. Data were obtained by applying the respondent-driven sampling method to recruit 349 participants aged 18 years or older and who reported having had at least one sexual relationship with a man in the last 12 months. Data were collected from June to December 2016 in a semi-structured int

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Costantino, Maria, Valentina Giudice, Giuseppina Moccia, et al. "Sex, Age, and Previous Herpes Zoster Infection Role on Adverse Events Following Immunization with Adjuvanted Recombinant Vaccine." Pathogens 14, no. 2 (2025): 195. https://doi.org/10.3390/pathogens14020195.

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Adverse events following immunizations (AEFIs) with recombinant zoster vaccine (RZV) are underexplored in fragile populations. This study aims to assess incidence, duration, and characteristics of AEFIs, focusing on the impact of sex, age, and prior Herpes Zoster (HZ) infection in a frail population, including solid organ transplant recipients. We conducted an observational study on patients receiving RZV, and AEFIs were classified as local or systemic and analyzed for incidence, duration, and patterns across groups. We showed that females had a higher incidence of AEFIs (p = 0.02), both local

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Savioli, G., S. Pesenti, I. Ceresa, E. Oddone, and M. A. Bressan. "Access to E.D. for mental disorders during the first pandemic wave of 2019 coronavirus epidemic (CoViD-19): Presentation and severity at a lombardy ED." European Psychiatry 64, S1 (2021): S363—S364. http://dx.doi.org/10.1192/j.eurpsy.2021.974.

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IntroductionThe 2019 coronavirus epidemic (CoViD-19) in Italy originated in Lombardy, on February 21, 2020. The Fondazione IRCCS Policlinico San Matteo di Pavia has been involved in the management of the outbreak since its beginning. ED’ psychiatric population is considered fragile, at risk of under triage.ObjectivesWe evaluated all the population who went to the ED for mental disorder to assess the severity of cases evaluated as exit code and rate of hospitalization.MethodsWe evaluated all patients accessing our ED for mental disorder from February 22 to May 1, 2020 and during the same period

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Chandra, H. Sharat, and Vidyanand Nanjundiah. "The evolution of genomic imprinting." Development 108, Supplement (1990): 47–53. http://dx.doi.org/10.1242/dev.108.supplement.47.

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We explore three possible pathways for the evolution of genomic imprinting. (1) Imprinting may be advantageous in itself when imprinted and unimprinted alleles of a locus confer different phenotypes. If a segment of DNA is imprinted in the gametes of one sex but not in those of the other, it might lead to effects correlated with sexual dimorphism. More fundamentally, in certain organisms, sex determination might have evolved because of imprinting. When imprinting leads to chromosome elimination or inactivation and occurs in some embryos but not in others, two classes of embryos, differing in t

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