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Dissertations / Theses on the topic '(Franz P.)'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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1

Kordas, Wojciech. "Mut zum Widerstand : die Verweigerung des Fahneneids von P. Franz Reinisch als prophetischer Protest /." St. Ottilien : Eos Verl, 2002. http://catalogue.bnf.fr/ark:/12148/cb388865308.

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2

Dezani, André Bersani. "Avaliação dos mecanismos envolvidos na permeabilidade de fármacos antirretrovirais por meio dos modelos ex vivo (células de Franz) e in vitro (PAMPA)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-24042017-144959/.

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Para fármacos administrados por via oral, o controle da extensão e da velocidade de absorção depende basicamente de duas importantes etapas: solubilidade do fármaco nos líquidos fisiológicos e sua permeabilidade através das membranas biológicas. Assim, o Sistema de Classificação Biofarmacêutica (SCB) foi proposto como uma ferramenta para o desenvolvimento de novos fármacos, de novas formulações e para auxiliar nos processos de bioisenção. No entanto, outro fator relacionado à biodisponibilidade e que deve ser considerado nos estudos biofarmacêuticos é o metabolismo. Desta forma, o Sistema de Classificação Biofarmacêutica de Distribuição de Fármacos (SCBDF) foi proposto com a finalidade de classificar os fármacos de acordo com suas características de solubilidade e de metabolismo de modo que seja possível avaliar e predizer o comportamento do fármaco in vivo. O metabolismo tem sido amplamente investigado, sobretudo as enzimas do citocromo P450, as quais estão presentes também nos enterócitos. Além disso, o SCBDF oferece um suporte quanto à avaliação dos mecanismos de permeabilidade envolvidos nos processos de absorção, interações fármaco-fármaco e interações fármaco-alimento. Assim, o presente trabalho teve como objetivo elucidar os mecanismos envolvidos na permeabilidade de fármacos antirretrovirais por meio dos modelos ex vivo (câmaras de difusão vertical tipo Franz) e in vitro (PAMPA, MDCK-MDR1 e microssomas) considerando os aspectos relacionados ao metabolismo intestinal e ao efluxo destes fármacos. Dada a importância da utilização de fármacos antirretrovirais na terapia medicamentosa contra a Síndrome da Imunodeficiência Adquirida (SIDA) e que estes medicamentos são normalmente administrados cronicamente, a compreensão dos mecanismos envolvidos na permeabilidade é de suma importância, uma vez que estes não estão totalmente esclarecidos e poucas informações são encontradas na literatura. Além disso, a biodisponibilidade de fármacos como estavudina, lamivudina e zidovudina indica variação na permeabilidade, necessitando de uma investigação científica mais aprofundada dos processos absortivos. Assim, segmentos de jejuno provenientes de ratos machos Wistar foram utilizados para a avaliação da permeabilidade intestinal dos referidos antirretrovirais considerando a avaliação de efluxo pela glicoproteína-P e o metabolismo intestinal pela CYP3A. De maneira complementar, estudos in vitro com o emprego de membranas artificiais paralelas (PAMPA) e culturas celulares de MDCK-MDR1 foram realizados com a finalidade de auxiliar na elucidação dos mecanismos de permeabilidade dos fármacos antirretrovirais. Além disso, a avaliação do metabolismo dos referidos fármacos foi realizada com o emprego de microssomas a fim de verificar se tais substâncias são substratos de enzimas da família CYP3A e, assim, verificar o impacto do metabolismo intestinal na absorção. Os resultados de permeabilidade obtidos em PAMPA foram: 0,74±0,11 x 10-6 cm/s para a estavudina, 0,25±0,12 x 10-6 cm/s para a lamivudina e 1,14±0,25 x 10-6 cm/s para a zidovudina. Já no modelo ex vivo com o emprego de câmaras de difusão vertical tipo Franz, os resultados foram: 1,56±0,32 x 10-5 cm/s para a estavudina, 1,26±0,27 x 10-5 cm/s para a lamivudina e 2,54±0,49 x 10-5 cm/s para a zidovudina. Portanto, com base nos resultados obtidos a partir dos dois métodos empregados, sugere-se que 30 outro mecanismo de transporte que não envolva a permeabilidade por difusão transcelular passiva possa estar relacionado à permeabilidade dos fármacos antirretrovirais. Com relação aos estudos de efluxo, os resultados obtidos a partir dos experimentos realizados em câmaras de difusão vertical tipo Franz demonstraram o aumento significativo da permeabilidade dos três antirretrovirais quando o inibidor de P-gp foi empregado, sendo: de 15,6 x 10-6 para 42,5 x 10-6 cm/s para a estavudina, de 12,6 x 10-6 para 37,5 x 10-6 cm/s para a lamivudina e de 25,4 x 10-6 para 56,6 x 10-6 cm/s para a zidovudina. Em culturas celulares MDCK-MDR1, os resultados de permeabilidade foram utilizados para a obtenção das razões entre as direções B→A e A→B. Os valores de Papp na condição inibida para os fármacos estudados apresentaram razão menor do que 1. Já a razão B→A/A→B para cada fármaco nos ensaios sem inibidor apresentou-se igual ou maior que 2, evidenciando a interação fármaco-transportador. Com base nisso, o modelo ex vivo com o emprego de segmentos intestinais em câmaras de difusão vertical tipo Franz apresentou-se adequado na avaliação do mecanismo de efluxo dos fármacos antirretrovirais, o que foi confirmado com os estudos realizados em MDCK-MDR1. Assim, os fármacos antirretrovirais estudados apresentaram interação significativa com a P-gp. Em relação aos estudos de metabolismo realizados em câmaras de difusão vertical tipo Franz, os resultados demonstraram grande variação na permeabilidade dos três antirretrovirais quando o inibidor de CYP3A foi empregado, sendo: de 15,6 x 10-6 para 23,5 x 10-6 cm/s para a estavudina, de 12,6 x 10-6 para 27,3 x 10-6 cm/s para a lamivudina e de 25,4 x 10-6 para 40,5 x 10-6 cm/s para a zidovudina. Já no modelo que emprega microssomas, os resultados de metabolização na ausência e na presença de inibidor de CYP3A foram: de 16,56% para 19,79% para a estavudina, de 14,56% para 15,55% para a lamivudina e de 17,85% para 16,48% para a zidovudina. Com base nisso, sugerese o emprego de microssomas para a determinação de metabolismo, uma vez que o método ex vivo empregado demonstrou grande variação entre os valores obtidos. Desta forma, observou-se que, para cada fármaco, não houve influência significativa no metabolismo pré-sistêmico relacionado às enzimas do complexo CYP3A, o que indica que a absorção oral das referidas substâncias não é limitada por tais enzimas. Portanto, a utilização dos diferentes métodos empregados no desenvolvimento do presente trabalho permitiu compreender os mecanismos envolvidos no transporte dos fármacos antirretrovirais, o que se torna de grande relevância nas etapas de desenvolvimento farmacêutico de novas moléculas e na compreensão de eventos clínicos ainda não esclarecidos atualmente.
For orally administered drugs, control of the extent and rate of absorption depends on two important steps: solubility of the drug in physiological liquids and their permeability across biological membranes. Thus, the Biopharmaceutics Classification System (BCS) has been proposed as a tool for the development of new drugs, new formulations and aid in the biowaiver processes. However, another factor related to bioavailability that should be considered in biopharmaceutic studies is the metabolism. Thus, the Biopharmaceutics Drug Disposition Classification System (BDDCS) has been proposed for drug classification according to their solubility and metabolism characteristics, so it is possible to evaluate and predict the in vivo behavior of a compound. Metabolism has been extensively investigated, especially cytochrome P450 enzymes, which are also expressed in enterocytes. Besides, BDDCS provides support in evaluating the permeability mechanisms involved in the absorption processes, drug-drug interactions and drug-food interactions. Thus, the present study aimed to evaluate the mechanisms of permeability of antiretroviral drugs through the ex vivo (Franz cells) and in vitro (PAMPA, MDCK-MDR1 and microsomes) models considering aspects related to the intestinal metabolism and efflux of these drugs. Given the importance of the use of antiretroviral drugs in drug therapy against Acquired Immune Deficiency Syndrome (AIDS) and that these drugs are usually administered in a long-term way, understanding the mechanisms involved in the permeability is of a great importance, since they are not totally elucidated and no information is found in the literature. In addition, drugs as stavudine, lamivudine and zidovudine indicate variation in the permeability, which require further scientific investigation of absorptive processes. Thus, jejunum segments from rats were used to evaluate the intestinal permeability of these antiretroviral drugs, considering the evaluation of efflux by P-glycoprotein and intestinal metabolism by CYP3A. In a complementary manner, in vitro studies using parallel artificial membranes (PAMPA) and cell cultures MDCK-MDR1 were performed to aid in the elucidation of the permeability mechanisms of antiretroviral drugs. Also, the evaluation of the metabolism was carried out using microsomes to verify if such substances are substrates of CYP3A, and verify the impact of the intestinal metabolism in the absorption. The permeability results obtained in PAMPA were: 0.74±0.11x10-6 cm/s for stavudine, 0.25±0.12x10-6 cm/s for lamivudine and 1.14±0.25x10-6 cm/s for zidovudine. In ex vivo method using the intestinal segments in Franz cells, the results were: 1.56±0.32x10-5 cm/s for stavudine, 1.26±0.27x10-5 cm/s for lamivudine and 2.54±0.49x10-5 cm/s for zidovudine. Thus, based on the results obtained from these two methods, it is suggested that the antiretroviral drugs present other transport mechanism that is different from transcellular passive diffusion. For efflux studies, results obtained from experiments performed in Franz cells shown the increase of the permeability of the three antiretroviral drugs when the P-gp inhibitor was used: from 15.6x10-6 to 42,5x10-6 cm/s for stavudine, from 12.6x10-6 cm/s to 37.5x10-6 cm/s for lamivudine, and 25.4x10-6 to 56.6x10-6 cm/s for zidovudine. In MDCK-MDR1, the permeability results were used for obtaining ratio values between the directions B→A and A→B. The Papp values obtained with 33 inhibitor shown a ratio less than 1. For ratio B→A/A→B for each drug in experiments without inhibitor, the values obtained was equal or greater than 2, which shows the interaction between drug and transporter. Based on that, the ex vivo model using intestinal segments in Franz cells seems to be adequate for evaluation of efflux mechanism of antiretroviral drugs, which was confirmed by MDCK-MDR1 studies. Thus, the antiretroviral drugs presented interaction with P-gp. For metabolism studies in intestinal segments in Franz cells, a wide range of standard deviation was observed for the three antiretroviral drugs when the CYP3A inhibitor was used: from 15.6x10-6 cm/s to 23.5x10-6 cm/s for stavudine, from 12.6x10-6 cm/s to 27.3x10-6 cm/s for lamivudine, and from 25.4x10-6 cm/s to 40.5x10-6 cm/s for zidovudine. In experiments in microsomes, the results of metabolization in the absence and presence of CYP3A inhibitor were: from 16.56 to 19.79% for stavudine, from 14.56 to 15.55% for lamivudine and from 17.85 to 16.48% for zidovudine. Based on that, it is suggested the use of microsomes for metabolism evaluation, since the ex vivo method presented high variability between the results obtained. For each drug, no significative influence in pre-systemic metabolism related to CYP3A enzymes was observed, which indicates that the oral absorption of the drugs is not limited by these enzymes. The use of different methods in this work allowed to understand the mechanisms involved in the transport of antiretroviral drugs, which is of a great relevance in drug development and in the understanding of clinical events currently not clarified.
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3

Jost, Franz [Verfasser], and P. [Akademischer Betreuer] Gratzfeld. "Sensorkonzept zur direkten Bestimmung von Zustandsgrößen an aktiv gelenkten Fahrwerken für Straßenbahnen / Franz Jost ; Betreuer: P. Gratzfeld." Karlsruhe : KIT-Bibliothek, 2020. http://d-nb.info/1205807683/34.

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4

Sugg, Timo Franz [Verfasser], and P. [Akademischer Betreuer] Lang. "Durchflusszytometrische Bestimmung der Minimal Residual Disease bei pädiatrischen Patienten mit akuten Leukämien / Timo Franz Sugg ; Betreuer: P. Lang." Tübingen : Universitätsbibliothek Tübingen, 2012. http://d-nb.info/1160517932/34.

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Graßl, Franz Christian [Verfasser], Manfred [Akademischer Betreuer] Scheer, Henri [Akademischer Betreuer] Brunner, and Frank-Michael [Akademischer Betreuer] Matysik. "Beiträge zur Transformation der E4-Tetraeder (E = P, As) durch Koordination an Komplexfragmente später Übergangsmetalle / Franz Christian Graßl. Betreuer: Manfred Scheer ; Henri Brunner ; Frank-Michael Matysik." Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1054801231/34.

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Pfaff, Florian Franz [Verfasser], and Meinrad P. [Akademischer Betreuer] Gawaz. "Interaktion zwischen Thrombozyten und CD34-positiven Zellen bei Patienten mit koronarer Herzerkrankung / Florian Franz Pfaff ; Betreuer: Meinrad P. Gawaz." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1160684472/34.

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7

Rieger, Thomas Norbert Franz [Verfasser]. "In-situ Charakterisierung von Entstehung und Bestandteilen von Q&P-Gefügen in einem Si-legierten TRIP-Stahl / Thomas Norbert Franz Rieger." Aachen : Shaker, 2015. http://d-nb.info/1080763007/34.

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Rieger, Thomas [Verfasser]. "In-situ Charakterisierung von Entstehung und Bestandteilen von Q&P-Gefügen in einem Si-legierten TRIP-Stahl / Thomas Norbert Franz Rieger." Aachen : Shaker, 2015. http://d-nb.info/1080763007/34.

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Dirschnabel, Daniela Elisabeth [Verfasser], Ulrich [Gutachter] Kück, and Franz [Gutachter] Narberhaus. "NAD(P)H oxidases are components of two distinct pathways regulating sexual development in the fungus Sordaria macrospora / Daniela Elisabeth Dirschnabel ; Gutachter: Ulrich Kück, Franz Narberhaus ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2014. http://d-nb.info/1189419556/34.

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Böttcher, Rene [Verfasser], K. –T [Akademischer Betreuer] Hoffmann, J. –. P. [Akademischer Betreuer] Schneider, Franz Wolfgang [Gutachter] Hirsch, and Matthias [Gutachter] Gutberlet. "Differenzierung von ZNS-Läsionen der Enzephalomyelitis disseminata mittels suszeptibilitätsgewichteter Magnetresonanzbildgebung (SWI) : Differenzierung von ZNS-Läsionen der Enzephalomyelitis disseminata mittels suszeptibilitätsgewichteter Magnetresonanzbildgebung (SWI) / Rene Böttcher ; Gutachter: Franz Wolfgang Hirsch, Matthias Gutberlet ; K.–T. Hoffmann, J.– P. Schneider." Leipzig : Universitätsbibliothek Leipzig, 2017. http://d-nb.info/1240846991/34.

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Reid, Christopher W. "Invested identities : the economics of self-development in the "Bildungsroman" /." Ann Arbor, Mich : UMI, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000252601.

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Jansen, Frank [Verfasser]. "Rekombinante Biosynthese von p-Cumarylalkohol in E. coli / Frank Jansen." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2012. http://d-nb.info/1022733532/34.

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Frank, Nicolas [Verfasser]. "d10-Metallkomplexe des p-tert-Butyltetramercaptotetrathiacalix[4]arens / Nicolas Frank." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1219507644/34.

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Frank, Kerstin [Verfasser], and H. P. [Akademischer Betreuer] Schuchmann. "Formulieren von Anthocyanen in Doppelemulsionen / Kerstin Frank. Betreuer: H. P. Schuchmann." Karlsruhe : KIT-Bibliothek, 2012. http://d-nb.info/1020663553/34.

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Werner, Frank [Verfasser], and P. [Akademischer Betreuer] Schmitt. "Applied Formal Methods in Wireless Sensor Networks / Frank Werner. Betreuer: P. Schmitt." Karlsruhe : KIT-Bibliothek, 2009. http://d-nb.info/1014220807/34.

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Frank, Daniel [Verfasser], Jürgen P. [Akademischer Betreuer] Geist, Jürgen P. [Gutachter] Geist, and Richard E. [Gutachter] Connon. "Neurotoxicity and Immune Responses of Fish to Environmental Stressors / Daniel Frank ; Gutachter: Jürgen P. Geist, Richard E. Connon ; Betreuer: Jürgen P. Geist." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1183259530/34.

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Schweizer, Frank [Verfasser], and P. [Akademischer Betreuer] Gumbsch. "Simulation von Laserschweißprozessen zur Bewertung der wasserstoffbeeinflussten Kaltrissneigung hochfester Stähle / Frank Schweizer ; Betreuer: P. Gumbsch." Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1122461488/34.

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Tömösközi, Mate [Verfasser], Frank H. P. [Gutachter] Fitzek, Michele [Gutachter] Zorzi, and Sergio [Gutachter] Palazzo. "Next Generation Header Compression / Mate Tömösközi ; Gutachter: Frank H. P. Fitzek, Michele Zorzi, Sergio Palazzo." Dresden : Technische Universität Dresden, 2021. http://d-nb.info/1232410675/34.

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Ezroura, Mohammed. "Criticism between scientificity and ideology : theoretical impasses in F.R. Leavis and P. Macherey." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30697.

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While focussing on the metaphor of scientificity in Leavis's and Macherey's writings, this dissertation addresses other questions central to criticism, cultural theory, and the philosophy of science. Whereas Leavis opposes scientificity, Macherey proposes "scientific criticism" as imperative to theoretical practice. Between the two critics, scientificity reveals its major metamorphoses. This study is divided into four major parts. Part One situates the concept of scientificity in the modern debate between critics and philosophers of science. I compare their problematization of scientificity to the way this notion has been represented in literary criticism. The debate blurs the boundary between scientific and literary knowledge, and brings the question of ideology in scientific discourse to the fore. Scientificity is thus bound with ideology as an epistemological practice. Part two focusses on Leavis's rejection of scientificity. In three chapters here I investigate the significance of Leavis's definition of "organic culture," "civilization," "science," and "criticism." These are all rooted in Arnold's cultural paradigm, which privileges a traditional order. Leavis's opposition to "theory," "science," and "philosophy" problematizes his principles of "precision," "analysis," and "standards." His controversies with CP. Snow's scientism and with Marxism reveal his concern with theory and scientific epistemology. His defence of "ambiguity," and "impossibility of definition" also makes his framework confront a theoretical impasse that is revealed by a desire to theorize criticism—Leavis's duty towards society— and a fear of theory and science, perceived as destructive. Part Three, comprising three chapter, considers Macherey's scientific criticism. His notions of the "structure of absence" and "symptomatic reading" are central to his theorization of criticism, science, and ideology. These are formulated through Freud's categories of dream analysis, Saussure's notion of difference, and Althusser's conception of ideology. For Macherey, scientific criticism negates ideology. But his emphasis on "absence" as constitutive of scientificity brings his epistemology to a theoretical impasse that resembles Leavis's. Macherey's anchoring of meaning in economic structures, in ideology, and in Marxism as "science," problematizes his scientific project because it abandons "absence." Part Four concludes the dissertation by investigating ways in which Leavis and Macherey illustrate the importance of an epistemological phenomenon in literary studies: criticism's struggle with scientificity. Whether opposed or defended, scientificity has helped criticism to emulate the hegemonic discourse of science and to combat rival critical strategies. However, to dispel "scientific" delusions, criticism must scrutinize its affiliation with ideology both in scientific method and in theory.
Arts, Faculty of
English, Department of
Graduate
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Gaspard, Marion. "Fondements et enjeux de la théorie mathématique de l'épargne de Frank P. Ramsey (1928) : contribution à une histoire de la macroéconomie non keynésienne." Paris 1, 2002. http://www.theses.fr/2002PA010052.

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La thèse revient tout d'abord sur la théorie de l'épargne optimale que propose Frank Ramsey dans " A Mathematical Theory of Saving " (1928), afin d'en retracer la logique argumentative et d'en retrouver l'interprétation économique initiale. Nous montrons ensuite que cette théorie trouve son origine dans les débats de théorie et de politique économique des almées 1920 à Cambridge. La réalisation théorique de 1928 est enfin analysée à la lumière des présupposés et de la méthodologie de Ramsey, tels qu'ils apparaissent dans les écrits épistémologiques de ce dernier, et notamment dans la critique que Ramsey adresse au Treatise on Probability de Keynes. En comparant l'analyse de Ramsey avec les premiers écrits de Keynes, nous repérons la naissance de deux représentations des comportements, individuels et collectifs, qui, encore aujourd'hui, alimentent l'analyse macroéconomique.
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Amusan, Akinwumi Abimbola [Verfasser], Edmund P. [Akademischer Betreuer] Burte, and Frank T. [Akademischer Betreuer] Edelmann. "Plasma-assisted atomic layer deposition for microelectronics applications / Akinwumi Abimbola Amusan ; Edmund P. Burte, Frank T. Edelmann." Magdeburg : Universitätsbibliothek, 2016. http://d-nb.info/1119867185/34.

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Flüchter, Peter [Verfasser], and Frank-Gerald P. [Akademischer Betreuer] Pajonk. "Krisenintervention im Notarztdienst : Evaluierung eines videokasuistisch gestützten Fort- und Weiterbildungsprogramms / Peter Flüchter ; Betreuer: Frank-Gerald P. Pajonk." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/120573533X/34.

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Doppler, Klaus Eugen [Verfasser], and Frank P. [Akademischer Betreuer] Nothdurft. "Untersuchungen zum Frakturverhalten von geraden und abgewinkelten Implantataufbauten aus Zirkoniumdioxid / Klaus Eugen Doppler. Betreuer: Frank P. Nothdurft." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1052908993/34.

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Malz, Frank [Verfasser], A. [Gutachter] Zschunke, M. [Gutachter] Linscheid, and P. [Gutachter] Reich. "Quantitative NMR-Spektroskopie als Referenzverfahren in der analytischen Chemie / Frank Malz ; Gutachter: A. Zschunke, M. Linscheid, P. Reich." Berlin : Humboldt-Universität zu Berlin, 2003. http://d-nb.info/1207635898/34.

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Samorí, Paolo [Verfasser], Frans C. De [Gutachter] Schryver, Jürgen P. [Gutachter] Rabe, and Klaus [Gutachter] Rademann. "Self-assembly of conjugated (macro)molecules / Paolo Samori ; Gutachter: Frans C. De Schryver, Jürgen P. Rabe, Klaus Rademann." Berlin : Humboldt-Universität zu Berlin, 2000. http://d-nb.info/1207658707/34.

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Schönherr, Frank [Verfasser]. "Verankerung der Semantik veränderlicher Situations-Fakten und symbolischer Aktionen in der hybriden Roboterkontrollarchitektur DD&P / Frank Schönherr." Aachen : Shaker, 2004. http://d-nb.info/1181604303/34.

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Merker, Sabine [Verfasser], and Frank P. [Akademischer Betreuer] Nothdurft. "Frakturverhalten von implantatgetragenen und implantatzahngetragenen vollkeramischen Seitenzahnbrücken unter Verwendung von Zirkoniumoxid-Abutments / Sabine Merker. Betreuer: Frank P. Nothdurft." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434637/34.

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Moura, Elvis Dion Domingues. "Os 300 espartanos de Frank Miller : tra?o, cor e nankin reinterpretam o mito na p?s-modernidade." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2010. http://tede2.pucrs.br/tede2/handle/tede/4430.

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O presente trabalho discute as imagens de Frank Miller enquanto comunica??o. Tais imagens representam uma linguagem visual atrav?s da narrativa das hist?rias em quadrinhos contempor?neas, uma vez que percebemos a identifica??o da visualidade p?s-moderna no estilo de Frank Miller. A Hermen?utica de Profundidade referida por John Thompson foi a metodologia escolhida para possibilitar o desenvolvimento desta disserta??o. Inicialmente aborda-se a hist?ria em quadrinhos e suas principais caracter?sticas, estilos e g?neros. Apresenta-se seu quadro evolutivo durante as d?cadas e seus modos de produ??o e interpreta??o. Ap?s, tratam-se quest?es te?ricas relacionadas ? comunica??o visual e ? modernidade. Durante a classifica??o das eras da hist?ria em quadrinhos, aborda-se outros autores dos anos 1980 que evidenciam os marcos iniciais da visualidade p?s-moderna na arte sequencial. As imagens de Alan Moore e Neil Gaiman comparadas ?s de Frank Miller e o aprofundamento sobre Pop Art reiteram o contexto s?cio-hist?rico da p?s-modernidade. Assim, refere-se ? trajet?ria de Frank Miller na produ??o de hist?ria em quadrinhos, e suas contribui??es imag?sticas. A visualidade de Frank Miller ? analisada e interpretada ? luz da Hermen?utica de Profundidade de Thompson, revelando multiplicidades, hibrida??es e apropria??es contextualizadas na visualidade p?s-moderna. Essas no??es ligam a obra de Frank Miller ? comunica??o visual contempor?nea. Percebeu-se a sobreviv?ncia do mito na visualidade de Frank Miller e suas possibilidades de interpreta??o na comunica??o visual.
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Rapp, Insa [Verfasser], Eric P. [Akademischer Betreuer] Achterberg, and Martin [Gutachter] Frank. "Trace metal sources and cycling in tropical oxygen minimum zones / Insa Rapp ; Gutachter: Martin Frank ; Betreuer: Eric P. Achterberg." Kiel : Universitätsbibliothek Kiel, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:8-diss-239971.

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Ludwig, Kristin [Verfasser], Ignacio [Gutachter] Rubio, Frank-D. [Gutachter] Böhmer, and Matthias P. [Gutachter] Wymann. "The role of mTORC1 in immune adaptation to inflammatory stress / Kristin Ludwig ; Gutachter: Ignacio Rubio, Frank-D. Böhmer, Matthias P. Wymann." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/1206604948/34.

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Reso, Denis [Verfasser], Edmund P. [Akademischer Betreuer] Burte, and Frank T. [Akademischer Betreuer] Edelmann. "Chemische Gasphasenabscheidung von Germanium-Chalkogen-Verbindungen für die Verwendung in nichtflüchtigen Festkörperspeichern / Denis Reso. Betreuer: Edmund P. Burte ; Frank T. Edelmann." Magdeburg : Universitätsbibliothek, 2013. http://d-nb.info/105413538X/34.

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Menzel, Barraqueta Jan-Lukas [Verfasser], Eric P. [Akademischer Betreuer] Achterberg, and Martin [Gutachter] Frank. "The biogeochemical cycle of dissolved aluminium in the Atlantic Ocean / Jan-Lukas Menzel Barraqueta ; Gutachter: Martin Frank ; Betreuer: Eric P. Achterberg." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1234981521/34.

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Torre, Arranz Roberto [Verfasser], Frank H. P. [Gutachter] Fitzek, Marcos [Gutachter] Katz, and Qi [Gutachter] Zhang. "Agile Mobile Edge Computing and Network-coded Cooperation in 5G / Roberto Torre Arranz ; Gutachter: Frank H. P. Fitzek, Marcos Katz, Qi Zhang." Dresden : Technische Universität Dresden, 2021. http://d-nb.info/1238140572/34.

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Otter, Stephanie Edda [Verfasser], and Frank P. [Akademischer Betreuer] Nothdurft. "Einfluss der Restaurationsform und Anzahl der Approximalkontakte auf die Bruchlast endodontisch behandelter Prämolaren mit Klasse-II-Kavitäten / Stephanie Edda Otter. Betreuer: Frank P. Nothdurft." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052339263/34.

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Braun, Falko [Verfasser], Otto W. [Gutachter] Witte, Frank [Gutachter] Richter, and Jens P. [Gutachter] Dreier. "Neugeborene Nervenzellen nach kortikaler Streudepolarisierung : funktionelle Integration in neuronale Netzwerke mit Verbindungen zum räumlichen Gedächtnis / Falko Braun ; Gutachter: Otto W. Witte, Frank Richter, Jens P. Dreier." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/1207272493/34.

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36

Grüttner, Stefanie Katharina [Verfasser], Frank [Akademischer Betreuer] Kempken, and Dietrich [Gutachter] Ober. "Funktionelle Analyse des P-Klasse pentatricopeptide repeat Proteins DWEORG1 in Bezug auf die mitochondriale Translation in Arabidopsis thaliana / Stefanie Katharina Grüttner ; Gutachter: Dietrich Ober ; Betreuer: Frank Kempken." Kiel : Universitätsbibliothek Kiel, 2021. http://d-nb.info/123224029X/34.

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37

Felgendreher, Frank Verfasser], and Elisabeth [Akademischer Betreuer] [Allgoewer. "Alternative monetary institutional policies of H. P. Minsky and F. A. Hayek : the comparison of two alternative theories of inherent financial instability in a capitalistic economy / Frank Felgendreher. Betreuer: Elisabeth Allgoewer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1071948334/34.

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38

JIANG, JING. "Topologically Designed Cylindrical and Spherical Building Blocks to Construct Modular-Assembled Structures in Giant Shape-Amphiphiles." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1523855196482307.

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Krause, Maren [Verfasser], Frank [Akademischer Betreuer] Emmrich, Peter [Akademischer Betreuer] Ahnert, Ulrich [Gutachter] Sack, and Christoph [Gutachter] Baerwald. "Genetische Variabilität des Cytochrom P 450- Systems im Zusammenhang mit einem erhöhten Risiko für Rheumatoide Arthritis : Analyse von Einzelnukleotid-Polymorphismen in Kandidatengenen der Rheumatoiden Arthritis / Maren Krause ; Gutachter: Ulrich Sack, Christoph Baerwald ; Frank Emmrich, Peter Ahnert." Leipzig : Universitätsbibliothek Leipzig, 2014. http://d-nb.info/1238601952/34.

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Hoischen, Nadine Verfasser], Frank [Akademischer Betreuer] Edelmann, Burkert [Akademischer Betreuer] Pieske, Christoph [Akademischer Betreuer] [Herrmann-Lingen, and Wolfgang [Akademischer Betreuer] Himmel. "Einfluss von körperlichem Training auf verschiedene Aspekte der Lebensqualität bei Patienten mit diastolischer Herzinsuffizienz : Ergebnisse der prospektiven, randomisierten und kontrollierten Study Ex-DHF-P / Nadine Hoischen. Gutachter: Burkert Pieske ; Christoph Herrmann-Lingen ; Wolfgang Himmel. Betreuer: Frank Edelmann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/1044073942/34.

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Wenzel, Ute Verfasser], Ivo W. [Akademischer Betreuer] [Rangelow, D. Frank [Akademischer Betreuer] Ogletree, and Teodor P. [Akademischer Betreuer] Gotszalk. "Fabrication and characterization of self-sensing and self-actuating piezoresistive microscale silicon cantilevers for an integrated scanning probe microscopy and scanning electron microscopy system / Ute Wenzel. Gutachter: D. Frank Ogletree ; Teodor P. Gotszalk. Betreuer: Ivo W. Rangelow." Ilmenau : Universitätsbibliothek Ilmenau, 2013. http://d-nb.info/1034527770/34.

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Frank, Christiane [Verfasser], Mathias M. [Akademischer Betreuer] Maier, Mathias M. [Gutachter] Maier, and Chris P. [Gutachter] Lohmann. "Pharmakologische Vitreolyse mit Ocriplasmin (Jetrea®) als Behandlungsoption bei symptomatischer fokaler vitreomakulärer Traktion mit oder ohne Makulaforamen (≤400 µm) im Vergleich zur transkonjunktivalen Vitrektomie / Christiane Frank ; Gutachter: Mathias M. Maier, Chris P. Lohmann ; Betreuer: Mathias M. Maier." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1220831336/34.

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43

Diagre, Denis. "Le jardin botanique de Bruxelles (1826-1912): miroir d'une jeune nation." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210873.

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GROULÍK, Lukáš. "Obnova kulturních památek, především sakrálních, ve venkovských obcích Československa po roce 1989." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-47899.

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Abstract:
This thesis deals with cultural sights reconstruction, particularly of sacral character, in villages of Český Krumlov district - in a region formerly inhabited by German population. The introductory parts focus on the development of Czech-German co-existence in Czech lands with its historical chapters, as well as on the impact of the 1939‑1989 events on cultural sights condition in the Czech borderland, particularly in the region of Český Krumlov. The following part is dedicated to history and mainly to the reconstruction of these sights. These reconstructions are a common venture of a cross-border cooperation of Czechs with expatriated German compatriots. The final part of the thesis is enriched by brief biographies of significant people who have bonds to this region.
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Frank, Nadine P. R. [Verfasser]. "Umsetzung von Kohlenwasserstoffen in SOFCs / Nadine P. R. Frank." 2009. http://d-nb.info/1000452301/34.

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Maier-Rigaud, Frank P. [Verfasser]. "Four contributions to experimental economics / vorgelegt von Frank P. Maier-Rigaud." 2008. http://d-nb.info/990163520/34.

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47

Strieder, Frank [Verfasser]. "Astrophysikalischer S-Faktor von 7Be(p,γ)8B [7 Be(p, gamma) 8 B] : verbesserte und neuartige Meßtechniken / vorgelegt von Frank Strieder." 2000. http://d-nb.info/960207341/34.

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Frank, Simon P. C. [Verfasser]. "Rolle von SNARE-Proteinen bei der Mediatorfreisetzung humaner Mastzellen / vorgelegt von Simon P. C. Frank." 2010. http://d-nb.info/1004030215/34.

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49

Schilling, Frank-Peter [Verfasser]. "Diffractive jet production in deep inelastic e+p collisions at HERA / vorgelegt von Frank-Peter Schilling." 2001. http://d-nb.info/961853298/34.

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Schümann, Frank [Verfasser]. "Messung des astrophysikalischen S-Faktors der Reaktion 7Be(p,γ)8B [7 Be(p,gamma) 8 B] durch Coulombaufbruch von 8B / vorgelegt von Frank Schümann." 2002. http://d-nb.info/965035581/34.

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