Relevant bibliographies by topics / Franz vertical diffusion cell

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Franz vertical diffusion cell'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Franz vertical diffusion cell"

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Bartos, Csilla, Piroska Szabó-Révész, Tamás Horváth, Patrícia Varga, and Rita Ambrus. "Comparison of Modern In Vitro Permeability Methods with the Aim of Investigation Nasal Dosage Forms." Pharmaceutics 13, no. 6 (2021): 846. http://dx.doi.org/10.3390/pharmaceutics13060846.

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Nowadays, the intranasal route has become a reliable alternative route for drug administration to the systemic circulation or central nervous system. However, there are no official in vitro diffusion and dissolution tests especially for the investigation of nasal formulations. Our main goal was to study and compare a well-known and a lesser-known in vitro permeability investigation method, in order to ascertain which was suitable for the determination of drug permeability through the nasal mucosa from different formulations. The vertical diffusion cell (Franz cell) was compared with the horizo
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Salamanca, Constain, Alvaro Barrera-Ocampo, Juan Lasso, Nathalia Camacho, and Cristhian Yarce. "Franz Diffusion Cell Approach for Pre-Formulation Characterisation of Ketoprofen Semi-Solid Dosage Forms." Pharmaceutics 10, no. 3 (2018): 148. http://dx.doi.org/10.3390/pharmaceutics10030148.

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This study aimed to evaluate and compare, using the methodology of Franz diffusion cells, the ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional suspension. The second aim was to show that this methodology might be easily applied for the development of semi-solid prototypes and claim proof in pre-formulation stages. Drug release analysis was carried out under physiological conditions (pH: 5.6 to 7.4; ionic strength 0.15 M; at 37 °C) for 24 h. Three independent vertical Franz cells were used with a nominal volume of the acceptor compartment of 125 mL and a diffusi
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Katakam, Lakshmi Narasimha Rao, and Naresh Kumar Katari. "Development of in-vitro release testing method for permethrin cream formulation using Franz Vertical Diffusion Cell apparatus by HPLC." Talanta Open 4 (December 2021): 100056. http://dx.doi.org/10.1016/j.talo.2021.100056.

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Lukács, Bence, Ágnes Bajza, Dorottya Kocsis, et al. "Skin-on-a-Chip Device for Ex Vivo Monitoring of Transdermal Delivery of Drugs—Design, Fabrication, and Testing." Pharmaceutics 11, no. 9 (2019): 445. http://dx.doi.org/10.3390/pharmaceutics11090445.

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To develop proper drug formulations and to optimize the delivery of their active ingredients through the dermal barrier, the Franz diffusion cell system is the most widely used in vitro/ex vivo technique. However, different providers and manufacturers make various types of this equipment (horizontal, vertical, static, flow-through, smaller and larger chambers, etc.) with high variability and not fully comparable and consistent data. Furthermore, a high amount of test drug formulations and large size of diffusion skin surface and membranes are important requirements for the application of these
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Cadinoiu, Anca N., Delia M. Rata, Leonard I. Atanase, et al. "Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma." Polymers 11, no. 9 (2019): 1515. http://dx.doi.org/10.3390/polym11091515.

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More than one out of every three new cancers is a skin cancer, and the large majority are basal cell carcinomas (BCC). Targeted therapy targets the cancer’s specific genes, proteins, or tissue environment that contributes to cancer growth and survival and blocks the growth as well as the spread of cancer cells while limiting damage to healthy cells. Therefore, in the present study AS1411 aptamer-functionalized liposomes for the treatment of BCC were obtained and characterized. Aptamer conjugation increased liposome size, suggesting that the presence of an additional hydrophilic molecule on the
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Pena-Rodríguez, Eloy, Maria Lajarin-Reinares, Aida Mata-Ventosa, Sandra Pérez-Torras, and Francisco Fernández-Campos. "Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies." Pharmaceutics 13, no. 4 (2021): 533. http://dx.doi.org/10.3390/pharmaceutics13040533.

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Follicular targeting has gained more attention in recent decades, due to the possibility of obtaining a depot effect in topical administration and its potential as a tool to treat hair follicle-related diseases. Lipid core ethyl cellulose lipomers were developed and optimized, following which characterization of their physicochemical properties was carried out. Dexamethasone was encapsulated in the lipomers (size, 115 nm; polydispersity, 0.24; zeta-potential (Z-potential), +30 mV) and their in vitro release profiles against dexamethasone in solution were investigated by vertical diffusion Fran
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Pantelic, Ivana, Tanja Ilic, Bojan Markovic, Sanela Savic, Milica Lukic, and Snezana Savic. "A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells." Chemical Industry 72, no. 1 (2018): 47–53. http://dx.doi.org/10.2298/hemind170726019p.

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After decades long absence of an official consensus on the most appropriate evaluation method for in vitro skin performance of topical semisolid drugs, United States Pharmacopoeia (USP 39) finally suggested three types of testing equipment; however, all these provide data on drug release using inert synthetic membranes. Considering the need for a readily available membrane that would be more structurally similar to human skin, this paper provides a detailed protocol of a method for drug permeation assessment that uses heat-separated porcine ear epidermis and modified Franz diffusion cells. Pha
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Perminaite, Kristina, Anna Maria Fadda, Chiara Sinico, and Kristina Ramanauskiene. "Formulation of Liposomes Containing Royal Jelly and Their Quality Assessment." Journal of Nanoscience and Nanotechnology 21, no. 5 (2021): 2841–46. http://dx.doi.org/10.1166/jnn.2021.19053.

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Royal jelly, a gelatinuous consistency bee product produced and secreted by the hypopharyngeal and mandibular glands of worker honeybees, is beneficial in the treatment of dermatological conditions, likely through its content of the fatty acid 10-hydroxy-2-decenoic acid (10-HDA). However, 10-HAD poorly penetrates into skin. Thus, in this work, we produced royal jelly incorporated liposomes with the aim of increasing skin penetration of 10-HDA. Lipid nanocarriers were prepared by the thin lipid-film hydration method. Size and polydispersity index of the nanocarrier particles, and their stabilit
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Junqueira, Laura A., Hudson Polonini, Sharlene Loures, Nádia R. B. Raposo, Anderson O. Ferreira, and Marcos Antônio F. Brandão. "Permeation Efficacy of a Transdermal Vehicle with Steroidal Hormones and Nonsteroidal Anti-inflammatory Agents as Model Drugs." Current Drug Delivery 16, no. 2 (2018): 136–41. http://dx.doi.org/10.2174/1567201815666181024141849.

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Background: Transdermal delivery is an alternative route for the administration of drugs. However, it requires the development of vehicles that allow the drugs to cross the layers of the skin and reach the systemic circulation. Objective: In this study, a new transdermal vehicle was evaluated using progesterone, estradiol, estradiol + estriol (Biest) and ketoprofen administered as model drugs. </P><P> Methods: To evaluate the ex vivo permeation of the drugs, the Franz vertical diffusion cell with human skin was used. Results: After 24 h, the vehicle was able to deliver 18.32 &#
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Kim, Yujin, Moritz Beck-Broichsitter, and Ajay Banga. "Design and Evaluation of a Poly(Lactide-co-Glycolide)-Based In Situ Film-Forming System for Topical Delivery of Trolamine Salicylate." Pharmaceutics 11, no. 8 (2019): 409. http://dx.doi.org/10.3390/pharmaceutics11080409.

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Trolamine salicylate (TS) is a topical anti-inflammatory analgesic used to treat small joint pain. The topical route is preferred over the oral one owing to gastrointestinal side effects. In this study, a poly(lactide-co-glycolide) (PLGA)-based in situ bio-adhesive film-forming system for the transdermal delivery of TS was designed and evaluated. Therefore, varying amounts (0%, 5%, 10%, 20%, and 25% (w/w)) of PLGA (EXPANSORB® DLG 50-2A, 50-5A, 50-8A, and 75-5A), ethyl 2-cyanoacrylate, poly (ethylene glycol) 400, and 1% of TS were dissolved together in acetone to form the bio-adhesive polymeric
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Dissertations / Theses on the topic "Franz vertical diffusion cell"

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Mattiasson, Johanna. "Method development of an in vitro vertical Franz diffusion cell system to assess permeation of cosmetic active ingredients." Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414205.

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For evaluation of potential skincare ingredients, an in-house method using Static Franz diffusion cells and dialysis membranes was developed. Benzoic acid was chosen as a model substance along with L-ascorbic acid and α-Tocopherol. The cell conditions were tailored to encourage transmembrane diffusion. Benzoic acid was tested in acetate buffer (pH 4.6), which yielded a maximum flux of 0.91 ± 0.03 mg ∙ cm-2 ∙ h-1 and absorption of 103 ± 4 % out of the applied dose after 8 h. There were strong indications that benzoic acid ionization must be suppressed by lower pH to increase penetration rates.
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Benade, Reinette. "Formulation, in vitro release and transdermal diffusion of isoniazide and rifampicin for dermal tuberculosis / Reinette Benade." Thesis, North-West University, 2009. http://hdl.handle.net/10394/3982.

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Extra pulmonary tuberculosis makes up 10% of all tuberculosis cases and cutaneous tuberculosis (CTB) only a fraction of this 10%. CTB is caused by mainly Mycobacterium tuberculosis and can lead to scarring and deformities. The disease presents in different forms, from superficial granulomas to deeper ulceration and necrosis. Tissue cultures, polymerase chain reactions or purified protein derivative staining is used for the diagnosis of CTB (Barbagallo etal., 2002:320). Since the current treatment for CTB is oral anti-tubercular regimens and no topical treatment is available yet (Barbagallo et
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Praça, Fabíola Silva Garcia. "Liberação e permeação in vitro de produtos transdérmicos: um estudo metodológico de aparatos e de condições experimentais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-10102010-215730/.

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Liberação transdérmica de fármacos apresenta várias vantagens na terapêutica quando comparada com administração oral ou parenteral. Não existe até o momento nenhum método previsto na Farmacopéia Brasileira para realizar testes de liberação de fármacos em adesivos transdérmicos, outros compêndios oficiais como Farmacopéia Americana, Britânica e Européia, descrevem o aparato de pás sobre disco, o cilindro rotatório e o suporte recíproco. Atualmente a literatura descreve diversos tipos de células de difusão para liberação transdérmica das quais a célula de difusão de Franz tem sido a mais emprega
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Gajjar, Rachna M. "Absorption and Evaporation of Volatile Organic Solvents from Human Skin In Vitro." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282578243.

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Bergström, Anna. "Evaluation of skin-friendly solvents for increased solubility of a model NSAID in topical formulations." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24224.

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Bergström, A Utvärdering av hudvänliga lösningsmedel för ökad löslighet av NSAID i topikala formuleringar. Examensarbete i Farmakologi 15 poäng. Malmö Universitet: Fakulteten för Hälsa och Samhälle, Institutionen för Biomedicinsk Vetenskap, 2019.Introduktion Smärta har behandlats med topikala eller transdermala läkemedel i många år, men det är en utmaning att uppnå höga koncentrationer som kan transporteras över huden. För att kunna ersätta användandet av opioider vid behandling av måttlig till allvarlig smärta behövs mer effektiva formuleringar av transdermala läkemedel. Målet med denna studi
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Cowley, Amé. "The effect of selected natural oils on the permeation of flurbiprofen through human skin." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9008.

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In pharmaceutical sciences, topical delivery is a transport process of an active pharmaceutical ingredient (API) from a formulated dosage form to the target site of action. For most topical delivery systems, the skin surface, or the specific skin layers, such as the outermost layer of the stratum corneum, the lipids amid the corneocytes within the stratum corneum, the corneocytes themselves, the epidermis, dermis, Langerhans cells, Merckle cells or the appendageal structures can be the target delivery location. When an API is delivered to the skin, it has to firstly diffuse from the formulatio
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Van, Dyk Christina Petronella. "Transdermal delivery of 5-Fluorouracil with PheroidTM technology / C.P. van Dyk." Thesis, North-West University, 2008. http://hdl.handle.net/10394/1905.

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Han, Tao. "Ultrasound and insertion force effects on microneedles based drug delivery : experiments and numerical simulation." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/19591.

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Transdermal drug delivery (TDD) is limited by high resistance of the outer layer of the skin, namely stratum corneum which blocks any molecule that is larger than 500 Da. Research on TDD has become very active in recent years and various technologies have been developed to overcome the resistance of the stratum corneum. In particular, researchers have started to consider the possibility of combining the TDD technologies in order to achieve further increment for drug permeability. Microneedles (MNs) and sonophoresis are both promising technologies that can perform notable enhancement in drug pe
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Burger, Cornel. "Formulation, in vitro release and transdermal diffusion of pravastatin by the implementation of the delivery gap principle / Cornel Burger." Thesis, 2014. http://hdl.handle.net/10394/14221.

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Active pharmaceutical ingredients (APIs), which are incorporated in different formulations, i.e. creams, gels, foams, etc., are applied to the skin for a therapeutic effect. This therapeutic effect could either be required in the top layer of the skin (topical drug delivery) or deeper layers to reach the blood capillaries (transdermal drug delivery). Transdermal delivery avoids oral administration route limitations, such as first pass metabolism which is the rapid clearance of the drug in the gastrointestinal tract and degradation by enzymes. This delivery targets the drugs to skin sites, wher
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Franken, Anja. "In vitro skin permeation of selected platinum group metals / Anja Franken." Thesis, 2014. http://hdl.handle.net/10394/14236.

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Background: Platinum group metal (PGM) mining and refining is a large constituent of the mining sector of South Africa and contributes significantly to the gross domestic product. The PGMs include the rare metals platinum (Pt), palladium (Pd), rhodium (Rh), ruthenium (Ru), iridium (Ir) and osmium (Os). During the refining process workers are potentially exposed to various chemical forms of the PGMs via the respiratory and dermal exposure routes. Historically, emphasis has been on respiratory exposure while the extent of skin exposure is still unknown. Among the different forms of PGMs, the sal
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Book chapters on the topic "Franz vertical diffusion cell"

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Argel Pérez, Shaydier, Daiver Estiven Jiménez Gutiérrez, Alexander León Ramírez, et al. "Computational Simulation of Franz Diffusion Cell Method for Bacterial Nanocellulose Wound Dressings." In Communications in Computer and Information Science. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-61834-6_33.

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Conference papers on the topic "Franz vertical diffusion cell"

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Grabowski, F. E. "RHEOLOGY AND PRIMARY HEMOSTASIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643986.

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Overview The adhesion-aggregation of platelets to a site of vessel wall injury is a quintessential blood flow phenomenon. Firstly, platelets are driven to the vicinity of the vessel wall by a form of convective diffusion in which red cells both mechanically augment the effective platelet diffusivity (Turitto et al., Ind. Eng. Chem. Fund. 11:216-223, 1972; Grabowski et al., Ind. Eng. Chem. Fund. 11:224-232, 1972) and enhance the near-wall piatelet concentration (Ti11es and Eckstein, Microvasc Res., In press, 1987). Secondly, red cells subjected to physiologic shear forces are capable of secreti
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Ermawati, Dian Eka, Dyah Ayu Ambarwati, Niken Rosyana Dewi, Anif Nur Artanti, Sholichah Rohmani, and Wisnu Kundarto. "Optimization of hydroxymethylcellulose and sodium CMC of transdermal patch of antihypertension “Hortus Medicus” and transport through membrane using franz diffusion cell method." In THE 14TH JOINT CONFERENCE ON CHEMISTRY 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0005628.

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Hizir, F. E., T. Swamy, S. O. Ural, E. C. Kumbur, and M. M. Mench. "Characterization of the Micro Porous Layer - Catalyst Layer Interface Structure in Polymer Electrolyte Fuel Cells." In ASME 2009 7th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2009. http://dx.doi.org/10.1115/fuelcell2009-85092.

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The impact of interfacial contact between the catalyst layer (CL) and diffusion medium (DM) has important implications for the transport of heat, current, and multi-phase flow in the membrane electrode assembly. This work is motivated by the need to obtain a greater understanding of the impact of the micro porous layer (MPL) and CL morphologies and resulting interfacial contact on the fuel cell performance. In this effort, an array of different virgin mating CL and MPL surface structures was investigated. The mating surface morphology of the tested MPL and CL samples were digitally characteriz
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Friess, Brooks, and Mina Hoorfar. "Fluorescence Microscopy for the Measurement of the Surface Properties of the Gas Diffusion Layers of Fuel." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39523.

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One of the major problems of current proton exchange membrane (PEM) fuel cells is water management. The gas diffusion layer (GDL) of the fuel cell plays an important role in water management since humidification and water removal are both achieved through the GDL. Various numerical models developed to illustrate the multiphase flow and transport in the fuel cell require the accurate measurement of the GDL properties (wettability and surface energy). In a recent study, the capillary penetration technique has been used to measure indirectly the wettability of the GDL based on the experimental he
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Bahrami, Hafez, and Amir Faghri. "Bubbly, Two-Phase Flow in the Anode Channel of a Passive, Tubular Direct Methanol Fuel Cell." In ASME 2011 9th International Conference on Fuel Cell Science, Engineering and Technology collocated with ASME 2011 5th International Conference on Energy Sustainability. ASMEDC, 2011. http://dx.doi.org/10.1115/fuelcell2011-54732.

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A numerical study is presented to investigate the turbulent, two-phase, steady state, isothermal, bubbly flow characteristic in the anode channel of a passive, tubular direct methanol fuel cell (DMFC) in order to accurately predict the gas volume fraction distribution along the channel. Accumulation of carbon dioxide gas bubbles at the channel’s wall hinders the diffusion of the fuel from the channel to the catalyst layer. The conservation governing equations of the mass and momentum for both the continuous (methanol and water solution) and dispersed (CO2 bubbles) phases in the bubbly regime a
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Munoz, Andres, and Abhijit Mukherjee. "Effect of Gravity on Droplet Growth and Detachment Inside a Simulated PEM Fuel Cell Air Flow Channel With Hydrophobic Walls." In ASME 2013 11th International Conference on Fuel Cell Science, Engineering and Technology collocated with the ASME 2013 Heat Transfer Summer Conference and the ASME 2013 7th International Conference on Energy Sustainability. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fuelcell2013-18108.

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Water management still remains a challenge for proton exchange membrane fuel cells. Byproduct water formed in the cathode side of the membrane is wicked to the air supply channel through the gas diffusion layer. Water emerges into the air supply channel as droplets, which are then removed by the air stream. When the rate of water production is higher than the rate of water removal, droplets start to accumulate and coalesce with each other forming slugs consequently clogging the channels and causing poor fuel cell performance. It has been shown in previous experiments that rendering the channel
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Yang, Jui-Ming, and Philip R. LeDuc. "Three-Dimensional Laminar Flow for Localized Cellular Stimulation." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61643.

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Stimulation of living mammalian cells is primarily accomplished by the delivery of chemical agents to single cells or cell populations. Due to the fast response time of diffusion for these agents over the small size scale of individual cells, localized stimulation is limited. Currently, there are alternate techniques that can produce localized gradients of chemical stimulants over single cells, but they lack the ability for long time scale events that are requisite for many cellular processes because of this diffusion limitation. We have developed a device that is able to create chemical agent
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Abo Elazm, M. M., A. I. Shahata, A. F. Elsafty, and M. A. Teamah. "Numerical Investigation of a Three-Dimensional Laminar Mixed Convection Flows in Lid-Driven Cavity for Very Small Richardson Numbers." In ASME 2015 Power Conference collocated with the ASME 2015 9th International Conference on Energy Sustainability, the ASME 2015 13th International Conference on Fuel Cell Science, Engineering and Technology, and the ASME 2015 Nuclear Forum. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/power2015-49575.

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Laminar mixed convection in a three-dimensional lid driven cavity is numerically investigated. The top lid of the cavity is moving rightwards with a constant speed at a cold temperature. The bottom wall is maintained at an isothermal hot temperature, while the other vertical walls of the cavity are assumed to be insulated. In this study the mass diffusion was not taken into account and the fluid used was air. The flow and heat transfer behavior is studied for various Richardson number ranging from 5 × 10−5 to 3 × 10−4 at a fixed Prandtl number of 0.71 through analyzing the local Nusselt number
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Bearman, P. W., J. R. Chaplin, E. Fontaine, et al. "Comparison of CFD Predictions-of Multi-Mode Vortex-Induced Vibrations of a Tension Riser With Laboratory Measurements." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93177.

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This paper compares previously unpublished laboratory measurements of the vortex-induced vibrations of a vertical tension riser with predictions of five CFD-based riser codes. The experiments were carried out with a 13m long, 28mm diameter model riser of which the upper 7m was in air, and the remainder in water with a uniform flow generated by carriage motion at speeds up to 1m/s. In-line and cross-flow responses were computed from measurements of the curvature of the riser at 32 stations over its length. Key results are compared with blind CFD predictions in which the flow is computed in two
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Kitazawa, Daisuke, and Michio Kumagai. "Numerical Study on the Effects of Water Surface Shield and Oxygen Injection on Water Quality in Lake Biwa." In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-57669.

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Numerical simulation was carried out by means of a three-dimensional hydrostatic and ecosystem coupled model in order to predict the effects of water surface shield and oxygen injection on the water quality in Lake Biwa. Recent observations show the degradation of water quality particularly around the water bottom in Lake Biwa. One of the possible reasons of the degradation is the depletion in the vertical mixing of waters due to climate change. The meteorological observations at Hikone show that the atmospheric temperature has increased by 1°C in the recent 20 years. If the vertical mixing of
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